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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Cdc5l

Z-value: 1.96

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Transcription factors associated with Cdc5l

Gene Symbol	Gene ID	Gene Info
Cdc5l Ensembl NCBI MGI UniProt	ENSMUSG00000023932.8	Cdc5l

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Cdc5l	chr17_45432981_45433132	485	0.473916	-0.81	5.0e-02	Click!
Cdc5l	chr17_45322913_45323086	92685	0.062487	-0.76	7.7e-02	Click!
Cdc5l	chr17_45402203_45402541	13312	0.164763	0.53	2.8e-01	Click!
Cdc5l	chr17_45402856_45403089	12712	0.165237	0.52	2.9e-01	Click!
Cdc5l	chr17_45433278_45433437	184	0.565485	-0.51	3.0e-01	Click!

Activity of the Cdc5l motif across conditions

Conditions sorted by the z-value of the Cdc5l motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_96674138_96674322	2.44	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	3294	0.19
chr8_40878264_40878415	1.98	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	3391	0.2
chr9_19622407_19622600	1.79	Zfp317	zinc finger protein 317	199	0.91
chr2_65167070_65167237	1.60	Cobll1	Cobl-like 1	61294	0.12
chr19_36263973_36264136	1.60	Gm32027	predicted gene, 32027	383	0.85
chr7_73542824_73542975	1.46	Chd2	chromodomain helicase DNA binding protein 2	1069	0.35
chr11_16803107_16803282	1.33	Egfros	epidermal growth factor receptor, opposite strand	27508	0.17
chr6_119883269_119883450	1.27	Gm15532	predicted gene 15532	9561	0.15
chr1_172159886_172160228	1.23	Dcaf8	DDB1 and CUL4 associated factor 8	11109	0.1
chr2_52575707_52576080	1.20	Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	17326	0.18
chr19_40153581_40153732	1.19	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	33630	0.13
chr10_52420605_52420773	1.07	Nus1	NUS1 dehydrodolichyl diphosphate synthase subunit	3142	0.15
chr16_72808282_72808697	1.02	Robo1	roundabout guidance receptor 1	145285	0.05
chr15_6218493_6218848	0.97	Gm23139	predicted gene, 23139	67322	0.11
chr10_42723053_42723245	0.96	Gm15200	predicted gene 15200	24631	0.14
chr17_50378350_50378501	0.94	Gm49906	predicted gene, 49906	39173	0.17
chr17_24209788_24209956	0.94	Ntn3	netrin 3	341	0.67
chr6_144070883_144071211	0.92	Sox5os1	SRY (sex determining region Y)-box 5, opposite strand 1	49139	0.17
chr5_102010547_102010959	0.91	Wdfy3	WD repeat and FYVE domain containing 3	29195	0.16
chr3_60034453_60034756	0.89	Aadac	arylacetamide deacetylase	2728	0.23
chr4_4131153_4131310	0.86	A830012C17Rik	RIKEN cDNA A830012C17 gene	7090	0.2
chr14_122602774_122602990	0.85	Pcca	propionyl-Coenzyme A carboxylase, alpha polypeptide	37	0.98
chr7_132967481_132967632	0.84	Zranb1	zinc finger, RAN-binding domain containing 1	13303	0.14
chr9_116136291_116136469	0.81	Tgfbr2	transforming growth factor, beta receptor II	38885	0.15
chr15_42296635_42296795	0.78	Gm49452	predicted gene, 49452	23631	0.17
chr8_48663447_48663609	0.76	Tenm3	teneurin transmembrane protein 3	11156	0.25
chr9_83726172_83726335	0.75	Gm2109	predicted gene 2109	34778	0.15
chr4_53099364_53099515	0.75	Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	58513	0.11
chr13_63113927_63114104	0.74	Aopep	aminopeptidase O	6493	0.16
chr1_67168769_67168980	0.73	Cps1	carbamoyl-phosphate synthetase 1	45848	0.15
chr1_13374931_13375133	0.70	Ncoa2	nuclear receptor coactivator 2	949	0.34
chr17_43276058_43276209	0.68	Adgrf1	adhesion G protein-coupled receptor F1	5804	0.29
chr6_149149841_149149992	0.68	Etfbkmt	electron transfer flavoprotein beta subunit lysine methyltransferase	8270	0.13
chr13_21236545_21236716	0.67	Trim27	tripartite motif-containing 27	46769	0.08
chr2_58782122_58782273	0.66	Upp2	uridine phosphorylase 2	16872	0.2
chr2_72752692_72753055	0.65	6430710C18Rik	RIKEN cDNA 6430710C18 gene	2020	0.38
chr9_106235817_106235968	0.65	Alas1	aminolevulinic acid synthase 1	1192	0.3
chr3_77832077_77832234	0.64	Gm37576	predicted gene, 37576	40998	0.19
chr5_147320087_147320238	0.63	Urad	ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5) decarboxylase	2278	0.17
chr9_107305345_107305527	0.63	Gm17041	predicted gene 17041	3598	0.12
chr15_53146756_53146975	0.62	Ext1	exostosin glycosyltransferase 1	38997	0.23
chr18_66001524_66001695	0.62	Lman1	lectin, mannose-binding, 1	1009	0.44
chr13_114974629_114975014	0.62	Gm47776	predicted gene, 47776	39753	0.15
chr8_76152735_76152886	0.61	Gm45742	predicted gene 45742	35783	0.19
chr4_61807807_61807958	0.61	Mup-ps16	major urinary protein, pseudogene 16	10400	0.12
chr13_19395072_19395660	0.60	Gm42683	predicted gene 42683	87	0.82
chr1_45922232_45922396	0.58	Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	995	0.45
chr11_118201294_118201477	0.58	Gm11737	predicted gene 11737	3794	0.18
chr8_69396075_69396226	0.58	Gm10033	predicted gene 10033	611	0.64
chr1_67192772_67192960	0.58	Gm15668	predicted gene 15668	56334	0.12
chr8_22893059_22893230	0.58	Gm45555	predicted gene 45555	19555	0.14
chrX_101952539_101952717	0.57	Nhsl2	NHS-like 2	9169	0.17
chr1_67213641_67214357	0.57	Gm15668	predicted gene 15668	35201	0.17
chr3_52011351_52011543	0.57	Gm37465	predicted gene, 37465	7422	0.13
chr2_144550194_144550414	0.56	Rbbp9	retinoblastoma binding protein 9, serine hydrolase	486	0.71
chr19_36781247_36781436	0.56	Gm50112	predicted gene, 50112	37307	0.14
chr2_160797467_160797706	0.56	Plcg1	phospholipase C, gamma 1	37468	0.11
chr6_138156558_138156709	0.55	Mgst1	microsomal glutathione S-transferase 1	13779	0.27
chr9_74791015_74791321	0.55	Gm22315	predicted gene, 22315	9098	0.19
chr10_40511211_40511581	0.55	Gm18671	predicted gene, 18671	37496	0.14
chr14_59443633_59443793	0.55	Cab39l	calcium binding protein 39-like	2732	0.21
chr6_26490665_26490857	0.52	Gm24691	predicted gene, 24691	30331	0.26
chr10_86690190_86690443	0.52	Gm15344	predicted gene 15344	2779	0.1
chr10_107325957_107326150	0.51	Lin7a	lin-7 homolog A (C. elegans)	53659	0.14
chr11_79884650_79884847	0.51	Gm24454	predicted gene, 24454	8967	0.14
chr8_93073771_93073922	0.51	Ces1b	carboxylesterase 1B	6171	0.16
chr18_9732141_9732318	0.51	Gm17430	predicted gene, 17430	5559	0.13
chr18_59092890_59093288	0.51	Minar2	membrane integral NOTCH2 associated receptor 2	30578	0.22
chr18_12760468_12760619	0.50	Osbpl1a	oxysterol binding protein-like 1A	6594	0.15
chr14_62921769_62921931	0.50	Gm21021	predicted gene, 21021	51940	0.08
chr2_73278335_73278505	0.50	Sp9	trans-acting transcription factor 9	6454	0.16
chr6_119681087_119681251	0.50	Erc1	ELKS/RAB6-interacting/CAST family member 1	59064	0.13
chr2_84648708_84648914	0.50	Ctnnd1	catenin (cadherin associated protein), delta 1	274	0.82
chr19_31896510_31896684	0.50	Gm19241	predicted gene, 19241	17047	0.2
chr14_47295909_47296231	0.50	Mapk1ip1l	mitogen-activated protein kinase 1 interacting protein 1-like	2196	0.13
chr2_126934579_126934730	0.50	Sppl2a	signal peptide peptidase like 2A	1419	0.4
chr1_67153777_67153928	0.50	Cps1	carbamoyl-phosphate synthetase 1	30826	0.19
chr14_11125061_11125216	0.49	Fhit	fragile histidine triad gene	41	0.98
chr9_35060528_35060679	0.49	St3gal4	ST3 beta-galactoside alpha-2,3-sialyltransferase 4	4809	0.2
chr12_32936719_32936876	0.49	Gm47961	predicted gene, 47961	5065	0.13
chr2_167841674_167841862	0.48	1200007C13Rik	RIKEN cDNA 1200007C13 gene	8122	0.16
chr15_10177985_10178196	0.48	Prlr	prolactin receptor	309	0.94
chr13_37831757_37832025	0.48	Rreb1	ras responsive element binding protein 1	4498	0.22
chr15_36595891_36596298	0.48	Pabpc1	poly(A) binding protein, cytoplasmic 1	1332	0.34
chr4_53222171_53222454	0.48	4930412L05Rik	RIKEN cDNA 4930412L05 gene	4455	0.21
chr4_6268102_6268325	0.48	Gm11798	predicted gene 11798	7248	0.2
chr10_121501382_121501572	0.47	Gm46204	predicted gene, 46204	3874	0.13
chr10_85957276_85957442	0.47	Rtcb	RNA 2',3'-cyclic phosphate and 5'-OH ligase	464	0.7
chr3_63962435_63962754	0.47	Gm26850	predicted gene, 26850	1039	0.38
chr2_18435403_18435565	0.46	Dnajc1	DnaJ heat shock protein family (Hsp40) member C1	42654	0.16
chr1_67207008_67207510	0.46	Gm15668	predicted gene 15668	41941	0.15
chr11_16915471_16915622	0.46	Egfr	epidermal growth factor receptor	10361	0.18
chr13_24889964_24890115	0.45	D130043K22Rik	RIKEN cDNA D130043K22 gene	3042	0.18
chr1_67150788_67150939	0.45	Cps1	carbamoyl-phosphate synthetase 1	27837	0.2
chr1_162878367_162878530	0.45	Fmo2	flavin containing monooxygenase 2	2283	0.28
chr15_3470264_3470480	0.45	Ghr	growth hormone receptor	1272	0.6
chr6_94083257_94083610	0.44	Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	169743	0.03
chr5_131533929_131534082	0.44	Auts2	autism susceptibility candidate 2	392	0.86
chr10_68090841_68090992	0.44	Arid5b	AT rich interactive domain 5B (MRF1-like)	45710	0.14
chr17_77735813_77735964	0.44	Gm4711	predicted gene 4711	48539	0.17
chr16_24103845_24103996	0.43	Gm31583	predicted gene, 31583	13831	0.17
chr16_77461400_77461565	0.43	Mir99ahg	Mir99a and Mirlet7c-1 host gene (non-protein coding)	4439	0.14
chr3_138375535_138375764	0.43	Adh6-ps1	alcohol dehydrogenase 6 (class V), pseudogene 1	1459	0.3
chr19_26778570_26778772	0.43	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	7075	0.21
chr19_32509968_32510223	0.42	Minpp1	multiple inositol polyphosphate histidine phosphatase 1	24172	0.13
chr3_24595827_24596029	0.42	Gm24704	predicted gene, 24704	33854	0.24
chr2_138258025_138258203	0.42	Btbd3	BTB (POZ) domain containing 3	1444	0.6
chr15_38115472_38115623	0.42	Gm49312	predicted gene, 49312	36445	0.12
chr7_114788616_114788767	0.41	Insc	INSC spindle orientation adaptor protein	3362	0.24
chr18_76254862_76255034	0.40	Smad2	SMAD family member 2	6173	0.2
chr8_105811176_105811604	0.40	Ranbp10	RAN binding protein 10	15815	0.09
chr18_69659921_69660072	0.40	Tcf4	transcription factor 4	3329	0.36
chr17_24861821_24861975	0.40	Hagh	hydroxyacyl glutathione hydrolase	3697	0.1
chr15_36592351_36592502	0.39	Pabpc1	poly(A) binding protein, cytoplasmic 1	5000	0.15
chr17_88304125_88304285	0.39	1700116H05Rik	RIKEN cDNA 1700116H05 gene	1173	0.51
chr9_29643377_29643540	0.39	Gm15521	predicted gene 15521	50948	0.19
chr2_152733626_152733777	0.39	Id1	inhibitor of DNA binding 1, HLH protein	2550	0.16
chr14_17728323_17728474	0.38	Gm48320	predicted gene, 48320	42724	0.19
chr9_55324808_55324982	0.38	Nrg4	neuregulin 4	292	0.88
chr15_59430473_59430639	0.38	Nsmce2	NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase	56269	0.12
chr14_21181534_21181685	0.38	Adk	adenosine kinase	105457	0.06
chr3_116204045_116204241	0.38	Gm31651	predicted gene, 31651	3735	0.2
chr3_138455131_138455312	0.38	Adh5	alcohol dehydrogenase 5 (class III), chi polypeptide	816	0.51
chr17_84480594_84480759	0.37	Thada	thyroid adenoma associated	14471	0.18
chr9_57525829_57526000	0.37	Cox5a	cytochrome c oxidase subunit 5A	4581	0.1
chr9_70271019_70271199	0.37	Myo1e	myosin IE	63741	0.11
chr15_96686781_96687182	0.37	Slc38a2	solute carrier family 38, member 2	11710	0.16
chr4_131890254_131890430	0.37	Srsf4	serine and arginine-rich splicing factor 4	5134	0.11
chr11_50312756_50312907	0.36	Canx	calnexin	11841	0.12
chr11_19830960_19831117	0.36	Gm12029	predicted gene 12029	47386	0.15
chr6_124709647_124709812	0.36	Emg1	EMG1 N1-specific pseudouridine methyltransferase	1316	0.16
chr3_129606663_129606955	0.35	Elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	54429	0.09
chr6_51720618_51721036	0.35	Gm38811	predicted gene, 38811	9746	0.26
chr1_162571667_162571910	0.35	Vamp4	vesicle-associated membrane protein 4	562	0.74
chr17_46026823_46026974	0.35	Vegfa	vascular endothelial growth factor A	2017	0.29
chr4_3318885_3319036	0.35	Gm11786	predicted gene 11786	8215	0.21
chr11_75754732_75754970	0.35	Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	3247	0.21
chr6_100848852_100849036	0.34	Ppp4r2	protein phosphatase 4, regulatory subunit 2	3541	0.26
chr19_56519861_56520029	0.34	Dclre1a	DNA cross-link repair 1A	17437	0.17
chr7_46719930_46720314	0.34	Saa3	serum amyloid A 3	4422	0.1
chr6_149147053_149147326	0.34	Etfbkmt	electron transfer flavoprotein beta subunit lysine methyltransferase	5543	0.14
chr13_24144521_24144672	0.34	Carmil1	capping protein regulator and myosin 1 linker 1	10613	0.19
chr10_87582564_87582726	0.33	Pah	phenylalanine hydroxylase	35972	0.17
chr8_36319827_36320137	0.33	Gm5787	predicted gene 5787	53651	0.12
chr1_13646788_13647045	0.33	Gm38319	predicted gene, 38319	4168	0.2
chr5_103799401_103799738	0.33	Aff1	AF4/FMR2 family, member 1	15210	0.19
chr2_59159714_59159865	0.33	Ccdc148	coiled-coil domain containing 148	745	0.51
chr8_60947880_60948031	0.33	Clcn3	chloride channel, voltage-sensitive 3	6793	0.17
chr16_91829363_91829514	0.33	Itsn1	intersectin 1 (SH3 domain protein 1A)	1901	0.33
chr13_96795211_96795384	0.33	Ankrd31	ankyrin repeat domain 31	8701	0.18
chr8_47708640_47708855	0.33	E030037K01Rik	RIKEN cDNA E030037K01 gene	4519	0.12
chr13_43548363_43548529	0.33	Mcur1	mitochondrial calcium uniporter regulator 1	2326	0.24
chr9_92251108_92251259	0.32	Plscr1	phospholipid scramblase 1	841	0.56
chr11_83721035_83721187	0.32	Wfdc18	WAP four-disulfide core domain 18	11986	0.08
chrX_42198771_42199059	0.32	Stag2	stromal antigen 2	46735	0.14
chr6_91582630_91582782	0.32	Gm45215	predicted gene 45215	12052	0.14
chr3_96562255_96562584	0.32	Txnip	thioredoxin interacting protein	2365	0.12
chr4_6274068_6274223	0.32	Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	1486	0.41
chr11_113138785_113138971	0.32	2610035D17Rik	RIKEN cDNA 2610035D17 gene	34199	0.21
chr13_81323962_81324134	0.32	Adgrv1	adhesion G protein-coupled receptor V1	18788	0.24
chr5_87377364_87377538	0.32	Gm21049	predicted gene, 21049	2469	0.16
chr6_17252773_17253114	0.31	Cav2	caveolin 2	28242	0.16
chr16_93354892_93355097	0.31	1810053B23Rik	RIKEN cDNA 1810053B23 gene	892	0.57
chr2_4929917_4930068	0.31	Phyh	phytanoyl-CoA hydroxylase	7491	0.13
chr5_107369592_107369801	0.31	Brdt	bromodomain, testis-specific	9859	0.11
chr12_59382932_59383083	0.31	Gm48268	predicted gene, 48268	27398	0.14
chr19_56652542_56652727	0.31	Gm32441	predicted gene, 32441	11977	0.17
chr5_123185860_123186059	0.31	Hpd	4-hydroxyphenylpyruvic acid dioxygenase	3232	0.12
chr5_45278745_45278901	0.31	Gm43303	predicted gene 43303	26894	0.18
chr17_78269187_78269367	0.31	Crim1	cysteine rich transmembrane BMP regulator 1 (chordin like)	10906	0.19
chr6_119681279_119681450	0.31	Erc1	ELKS/RAB6-interacting/CAST family member 1	59259	0.13
chr18_76752705_76752870	0.31	Skor2	SKI family transcriptional corepressor 2	103618	0.07
chr14_120355831_120355991	0.31	Mbnl2	muscleblind like splicing factor 2	23330	0.21
chr1_156558196_156558347	0.31	Abl2	v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)	515	0.76
chr13_91756942_91757255	0.31	Gm27656	predicted gene, 27656	4992	0.17
chr9_111124362_111124513	0.30	Lrrfip2	leucine rich repeat (in FLII) interacting protein 2	4762	0.17
chr1_107939897_107940125	0.30	D830032E09Rik	RIKEN cDNA D830032E09 gene	3302	0.23
chr2_58755277_58755512	0.30	Upp2	uridine phosphorylase 2	182	0.95
chr15_97048203_97048354	0.30	Slc38a4	solute carrier family 38, member 4	1809	0.47
chr4_105116678_105116829	0.30	Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit	6863	0.27
chr15_66613033_66613221	0.30	Phf20l1	PHD finger protein 20-like 1	967	0.61
chr5_89352355_89352713	0.30	Gc	vitamin D binding protein	83094	0.1
chr3_14841128_14841305	0.30	Car3	carbonic anhydrase 3	22296	0.15
chr6_120686819_120687199	0.30	Cecr2	CECR2, histone acetyl-lysine reader	20427	0.18
chr7_73549643_73549987	0.29	1810026B05Rik	RIKEN cDNA 1810026B05 gene	2950	0.15
chr2_52613475_52613626	0.29	Bloc1s2-ps	biogenesis of lysosomal organelles complex-1, subunit 2, pseudogene	6204	0.24
chr8_68060407_68060639	0.29	Psd3	pleckstrin and Sec7 domain containing 3	1704	0.46
chrX_14897302_14897453	0.29	Gm9435	predicted gene 9435	58597	0.15
chr11_77516276_77516445	0.29	Abhd15	abhydrolase domain containing 15	376	0.44
chr13_113767020_113767171	0.29	Gm47463	predicted gene, 47463	2480	0.19
chr19_8218872_8219037	0.29	Slc22a29	solute carrier family 22. member 29	54	0.97
chr15_85766704_85766873	0.29	Ppara	peroxisome proliferator activated receptor alpha	5426	0.16
chr10_19878984_19879150	0.29	Gm48714	predicted gene, 48714	4620	0.19
chr2_27768705_27768856	0.28	Rxra	retinoid X receptor alpha	28579	0.21
chr11_107473047_107473198	0.28	Pitpnc1	phosphatidylinositol transfer protein, cytoplasmic 1	2423	0.19
chr9_110084221_110084372	0.27	Dhx30	DEAH (Asp-Glu-Ala-His) box polypeptide 30	695	0.58
chr9_83576757_83576932	0.27	Sh3bgrl2	SH3 domain binding glutamic acid-rich protein like 2	13	0.98
chr16_25967441_25967597	0.27	Gm4524	predicted gene 4524	11044	0.22
chr12_35265470_35265829	0.27	Gm44396	predicted gene, 44396	43242	0.16
chr7_73608284_73608633	0.27	Gm44734	predicted gene 44734	490	0.68

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Cdc5l

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.1	0.4	GO:0038161	prolactin signaling pathway(GO:0038161)
0.1	0.5	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.1	0.3	GO:1904017	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.1	0.4	GO:0000255	allantoin metabolic process(GO:0000255)
0.1	0.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.4	GO:0090240	positive regulation of histone H4 acetylation(GO:0090240)
0.1	0.2	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.1	0.2	GO:0006068	ethanol catabolic process(GO:0006068)
0.1	0.5	GO:0045908	negative regulation of vasodilation(GO:0045908)
0.1	0.2	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.1	0.4	GO:0051639	actin filament network formation(GO:0051639)
0.1	0.2	GO:1904339	negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1	0.2	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1	0.2	GO:0015819	lysine transport(GO:0015819)
0.1	0.2	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.1	0.2	GO:0032377	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1	0.3	GO:0044791	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.1	0.2	GO:0035627	ceramide transport(GO:0035627)
0.1	0.2	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.3	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0035973	aggrephagy(GO:0035973)
0.0	0.3	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.1	GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.0	0.1	GO:1901420	negative regulation of response to alcohol(GO:1901420)
0.0	0.2	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.2	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.2	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.2	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.1	GO:0035523	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.1	GO:0046881	positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.3	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.1	GO:1904690	regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0	0.1	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.0	0.1	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.3	GO:0071397	cellular response to cholesterol(GO:0071397)
0.0	0.2	GO:1903367	positive regulation of fear response(GO:1903367) positive regulation of behavioral fear response(GO:2000987)
0.0	0.3	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0072592	oxygen metabolic process(GO:0072592)
0.0	0.0	GO:1900084	regulation of peptidyl-tyrosine autophosphorylation(GO:1900084)
0.0	0.2	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.2	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.2	GO:0046146	tetrahydrobiopterin metabolic process(GO:0046146)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.1	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.2	GO:0097264	self proteolysis(GO:0097264)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.2	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.1	GO:0045950	negative regulation of mitotic recombination(GO:0045950)
0.0	0.1	GO:1901162	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0	0.0	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.0	0.1	GO:0090370	negative regulation of cholesterol efflux(GO:0090370)
0.0	0.1	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.0	GO:0014858	positive regulation of skeletal muscle cell proliferation(GO:0014858)
0.0	0.3	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.6	GO:0060218	hematopoietic stem cell differentiation(GO:0060218)
0.0	0.1	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.0	0.2	GO:0002091	negative regulation of receptor internalization(GO:0002091)
0.0	0.1	GO:0010694	positive regulation of alkaline phosphatase activity(GO:0010694)
0.0	0.1	GO:2001269	positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.0	0.1	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.1	GO:1900262	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0	0.1	GO:0071799	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	0.1	GO:1903753	negative regulation of p38MAPK cascade(GO:1903753)
0.0	0.2	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.2	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.0	0.1	GO:0045794	negative regulation of cell volume(GO:0045794)
0.0	0.1	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.1	GO:0090188	negative regulation of pancreatic juice secretion(GO:0090188)
0.0	0.2	GO:0007638	mechanosensory behavior(GO:0007638)
0.0	0.1	GO:1901970	positive regulation of mitotic sister chromatid separation(GO:1901970)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
0.0	0.1	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0	0.1	GO:0015838	amino-acid betaine transport(GO:0015838)
0.0	0.1	GO:0003241	growth involved in heart morphogenesis(GO:0003241)
0.0	0.0	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.1	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.0	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0070940	dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.0	0.6	GO:0007520	myoblast fusion(GO:0007520)
0.0	0.1	GO:0043651	linoleic acid metabolic process(GO:0043651)
0.0	0.0	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.0	0.1	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.0	GO:0010728	regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.0	0.0	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.0	0.0	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.0	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.1	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.0	0.1	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0	0.0	GO:1903972	regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.0	0.0	GO:0021943	formation of radial glial scaffolds(GO:0021943)
0.0	0.3	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.1	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0048386	positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0	0.1	GO:0045176	apical protein localization(GO:0045176)
0.0	0.0	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.0	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.0	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.2	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247)
0.0	0.0	GO:0015817	histidine transport(GO:0015817)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0030836	positive regulation of actin filament depolymerization(GO:0030836)
0.0	0.0	GO:1900135	positive regulation of renin secretion into blood stream(GO:1900135)
0.0	0.0	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.1	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.0	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.0	GO:0016103	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0	0.2	GO:0018126	protein hydroxylation(GO:0018126)
0.0	0.1	GO:0034625	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.0	GO:0070375	ERK5 cascade(GO:0070375)
0.0	0.0	GO:0035166	post-embryonic hemopoiesis(GO:0035166)
0.0	0.0	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:0051457	maintenance of protein location in nucleus(GO:0051457)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0045098	type III intermediate filament(GO:0045098)
0.1	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.4	GO:0005915	zonula adherens(GO:0005915)
0.1	0.2	GO:0032280	symmetric synapse(GO:0032280)
0.0	0.3	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.2	GO:0071556	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.1	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.1	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0	0.1	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.0	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.2	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.2	GO:1990909	Wnt signalosome(GO:1990909)
0.0	0.1	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.0	0.3	GO:0033655	host cell cytoplasm(GO:0030430) host cell cytoplasm part(GO:0033655)
0.0	0.2	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.1	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.1	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.8	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.0	0.2	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0032039	integrator complex(GO:0032039)
0.0	0.1	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.5	GO:0009295	nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0	0.0	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.0	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.3	GO:0048786	presynaptic active zone(GO:0048786)
0.0	0.2	GO:0034364	high-density lipoprotein particle(GO:0034364)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.0	GO:0004075	biotin carboxylase activity(GO:0004075)
0.1	0.6	GO:0016151	nickel cation binding(GO:0016151)
0.1	0.3	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.2	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0033142	progesterone receptor binding(GO:0033142)
0.1	0.2	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.1	0.2	GO:0097001	ceramide binding(GO:0097001)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.2	GO:0015189	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0	0.6	GO:0070402	NADPH binding(GO:0070402)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.2	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	0.3	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.1	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.0	0.2	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.2	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.3	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.2	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.1	GO:0098821	BMP receptor activity(GO:0098821)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.2	GO:0008494	translation activator activity(GO:0008494)
0.0	0.2	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.2	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0098639	collagen binding involved in cell-matrix adhesion(GO:0098639)
0.0	0.2	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.0	0.1	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.0	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.2	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.1	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.1	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.2	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0045503	dynein light chain binding(GO:0045503)
0.0	0.1	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.5	GO:0052770	coenzyme F390-A hydrolase activity(GO:0052770) coenzyme F390-G hydrolase activity(GO:0052771)
0.0	0.1	GO:0051185	coenzyme transporter activity(GO:0051185)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0033170	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.2	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.0	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.6	GO:0017046	peptide hormone binding(GO:0017046)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.0	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.0	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.2	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0008641	small protein activating enzyme activity(GO:0008641)
0.0	0.0	GO:0070699	type II activin receptor binding(GO:0070699)
0.0	0.1	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.0	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.0	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.0	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.4	GO:0052767	prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0	0.2	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.0	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.1	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.2	GO:0005537	mannose binding(GO:0005537)
0.0	0.1	GO:0102336	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.3	GO:0045296	cadherin binding(GO:0045296)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.0	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	0.0	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.7	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.6	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.4	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.1	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.6	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.3	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.4	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.3	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.1	0.6	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.5	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.4	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.8	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.3	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.4	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.3	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.3	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.2	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.0	0.0	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.2	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.0	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.0	REACTOME XENOBIOTICS	Genes involved in Xenobiotics