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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Clock

Z-value: 0.95

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Transcription factors associated with Clock

Gene Symbol	Gene ID	Gene Info
Clock Ensembl NCBI MGI UniProt	ENSMUSG00000029238.8	Clock

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Clock	chr5_76304107_76304258	366	0.632461	-0.87	2.3e-02	Click!
Clock	chr5_76303540_76303814	871	0.362384	-0.79	6.4e-02	Click!
Clock	chr5_76303922_76304075	550	0.511694	-0.75	8.5e-02	Click!
Clock	chr5_76304752_76304909	38	0.497417	-0.61	2.0e-01	Click!
Clock	chr5_76256521_76256672	17416	0.123511	0.44	3.8e-01	Click!

Activity of the Clock motif across conditions

Conditions sorted by the z-value of the Clock motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_124005727_124005878	1.93	Gm12902	predicted gene 12902	79568	0.07
chr16_48765285_48765461	1.64	Trat1	T cell receptor associated transmembrane adaptor 1	6583	0.2
chr9_74331308_74331508	1.27	Gm24141	predicted gene, 24141	31202	0.18
chr11_118265609_118265912	0.98	Usp36	ubiquitin specific peptidase 36	288	0.89
chr19_33489637_33489788	0.89	Lipo5	lipase, member O5	16521	0.14
chr19_33480626_33480777	0.88	Lipo5	lipase, member O5	7510	0.16
chr1_186358132_186358570	0.82	Gm37491	predicted gene, 37491	11036	0.28
chr17_71616884_71617050	0.78	Wdr43	WD repeat domain 43	752	0.37
chr14_20479878_20480231	0.75	Anxa7	annexin A7	67	0.96
chr4_101176228_101176401	0.75	Jak1	Janus kinase 1	9111	0.15
chr5_8157542_8157699	0.68	Gm21759	predicted gene, 21759	22016	0.16
chr10_95152509_95152710	0.58	Gm29684	predicted gene, 29684	6784	0.16
chr6_148833285_148833458	0.58	Ipo8	importin 8	1904	0.22
chr5_54060085_54060253	0.58	Stim2	stromal interaction molecule 2	14568	0.23
chr18_60922022_60922173	0.57	Camk2a	calcium/calmodulin-dependent protein kinase II alpha	3521	0.17
chr3_57435352_57435577	0.56	Tm4sf4	transmembrane 4 superfamily member 4	10150	0.22
chr7_68311256_68311435	0.47	4930405G09Rik	RIKEN cDNA 4930405G09 gene	5687	0.14
chr18_38406873_38407073	0.44	Ndfip1	Nedd4 family interacting protein 1	3423	0.18
chr3_96092507_96092658	0.43	Gm43554	predicted gene 43554	5711	0.11
chr19_37433970_37434137	0.41	Gm38345	predicted gene, 38345	603	0.45
chr10_89484240_89484407	0.41	Nr1h4	nuclear receptor subfamily 1, group H, member 4	22326	0.19
chrX_52044793_52044944	0.39	1700080O16Rik	RIKEN cDNA 1700080O16 gene	72096	0.11
chr3_65663297_65663473	0.39	Lekr1	leucine, glutamate and lysine rich 1	2843	0.19
chr2_156065132_156065865	0.37	Spag4	sperm associated antigen 4	55	0.94
chr11_61974443_61974594	0.37	Gm12274	predicted gene 12274	168	0.92
chr14_21832226_21832384	0.37	Vdac2	voltage-dependent anion channel 2	142	0.94
chr11_61092676_61092849	0.37	Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	26958	0.13
chr9_107674967_107675413	0.36	Gnat1	guanine nucleotide binding protein, alpha transducing 1	1251	0.24
chr4_63268906_63269081	0.35	Mir455	microRNA 455	12142	0.16
chr6_50526613_50527019	0.35	Gm26289	predicted gene, 26289	13218	0.13
chr11_44518397_44518764	0.35	Rnf145	ring finger protein 145	384	0.85
chr11_120811562_120811973	0.35	Fasn	fatty acid synthase	2066	0.16
chr10_96778362_96778523	0.34	Gm6859	predicted gene 6859	8614	0.17
chr6_28895214_28895400	0.34	Snd1	staphylococcal nuclease and tudor domain containing 1	15264	0.21
chr18_51128419_51128586	0.34	Prr16	proline rich 16	10764	0.3
chr7_144940237_144940434	0.33	Ccnd1	cyclin D1	410	0.78
chr1_131716457_131716608	0.32	Rab7b	RAB7B, member RAS oncogene family	19894	0.14
chr19_26764962_26765268	0.32	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	5376	0.24
chr8_46216985_46217176	0.31	Slc25a4	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 4	5796	0.11
chr2_134486534_134486685	0.31	Hao1	hydroxyacid oxidase 1, liver	67698	0.14
chr5_87373500_87373711	0.31	Gm35570	predicted gene, 35570	3122	0.14
chr14_69729450_69729663	0.31	Chmp7	charged multivesicular body protein 7	1319	0.33
chr7_79363538_79363689	0.31	Rlbp1	retinaldehyde binding protein 1	14090	0.13
chr11_5912275_5912428	0.30	Gck	glucokinase	2773	0.16
chr6_117577945_117578096	0.29	Gm9946	predicted gene 9946	10348	0.2
chr4_150218378_150218529	0.29	Gm13094	predicted gene 13094	9582	0.13
chr13_63665698_63665976	0.29	Gm47387	predicted gene, 47387	4040	0.18
chr19_40417273_40417445	0.29	Sorbs1	sorbin and SH3 domain containing 1	15092	0.22
chr16_43552061_43552212	0.29	Zbtb20	zinc finger and BTB domain containing 20	41828	0.16
chr11_82845122_82845302	0.28	Rffl	ring finger and FYVE like domain containing protein	880	0.45
chr8_109681119_109681276	0.28	Ist1	increased sodium tolerance 1 homolog (yeast)	3603	0.19
chr4_117981260_117981475	0.27	9530034E10Rik	RIKEN cDNA 9530034E10 gene	6331	0.16
chr10_19443595_19443775	0.27	Gm33104	predicted gene, 33104	43030	0.15
chr3_27283500_27283672	0.26	Gm37191	predicted gene, 37191	5526	0.2
chr10_62647927_62648078	0.26	Ddx50	DEAD (Asp-Glu-Ala-Asp) box polypeptide 50	221	0.89
chr15_93628063_93628509	0.26	Prickle1	prickle planar cell polarity protein 1	32395	0.18
chr1_88316757_88316908	0.25	Trpm8	transient receptor potential cation channel, subfamily M, member 8	2081	0.23
chr4_150119850_150120001	0.25	Slc2a5	solute carrier family 2 (facilitated glucose transporter), member 5	642	0.38
chr1_92834707_92834858	0.25	Gpc1	glypican 1	2813	0.15
chr3_129589919_129590070	0.24	Elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	37614	0.13
chr2_172511032_172511203	0.24	Gm14303	predicted gene 14303	1426	0.37
chr2_94430791_94430942	0.24	Api5	apoptosis inhibitor 5	1122	0.47
chr6_85919471_85919834	0.24	Gm18290	predicted gene, 18290	1766	0.16
chr7_137068941_137069100	0.24	Gm45499	predicted gene 45499	98800	0.07
chr16_87710092_87710297	0.24	Bach1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	11190	0.21
chr1_131619346_131619811	0.23	Gm8532	predicted gene 8532	13391	0.14
chr3_19225975_19226148	0.23	Gm16093	predicted gene 16093	1719	0.33
chr7_19675959_19676128	0.23	Apoc2	apolipoprotein C-II	821	0.36
chr5_124236533_124236706	0.22	Gm42425	predicted gene 42425	1105	0.35
chr8_45264437_45264634	0.22	F11	coagulation factor XI	2504	0.25
chr1_128440773_128440930	0.22	Dars	aspartyl-tRNA synthetase	23483	0.14
chr8_121967787_121967995	0.22	Gm17709	predicted gene, 17709	5931	0.11
chr1_194361449_194361616	0.22	4930503O07Rik	RIKEN cDNA 4930503O07 gene	138773	0.05
chr9_55277532_55277801	0.22	Nrg4	neuregulin 4	5906	0.19
chr8_95360199_95360374	0.21	Mmp15	matrix metallopeptidase 15	8018	0.13
chr10_21328387_21328563	0.21	4930455C13Rik	RIKEN cDNA 4930455C13 gene	13582	0.14
chr11_49233858_49234036	0.21	Mgat1	mannoside acetylglucosaminyltransferase 1	10244	0.12
chr7_16615699_16615891	0.21	Gm44589	predicted gene 44589	556	0.43
chr6_88737581_88737810	0.21	Gm44005	predicted gene, 44005	497	0.7
chr3_10174352_10174597	0.21	Pmp2	peripheral myelin protein 2	9455	0.12
chr18_50139098_50139320	0.20	Hsd17b4	hydroxysteroid (17-beta) dehydrogenase 4	3160	0.23
chr16_90282950_90283226	0.20	Scaf4	SR-related CTD-associated factor 4	1220	0.43
chr18_44540279_44540430	0.20	Mcc	mutated in colorectal cancers	20838	0.24
chr13_5714270_5714464	0.20	Gm35330	predicted gene, 35330	10075	0.27
chr9_106235574_106235761	0.20	Alas1	aminolevulinic acid synthase 1	1417	0.25
chr4_57250984_57251161	0.20	Ptpn3	protein tyrosine phosphatase, non-receptor type 3	29018	0.17
chr1_13312454_13312771	0.20	Ncoa2	nuclear receptor coactivator 2	12890	0.11
chr2_11513206_11513376	0.19	Gm10851	predicted gene 10851	8415	0.14
chr8_126309380_126309531	0.19	Slc35f3	solute carrier family 35, member F3	10897	0.27
chr6_91424316_91424467	0.19	Gm4575	predicted gene 4575	4492	0.12
chr5_124424178_124424509	0.19	Gm37415	predicted gene, 37415	354	0.67
chr5_45857473_45857990	0.19	4930449I04Rik	RIKEN cDNA 4930449I04 gene	89	0.53
chr9_72260390_72260691	0.19	Gm25163	predicted gene, 25163	3401	0.12
chr7_140767390_140767578	0.18	Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	3003	0.12
chr5_144370961_144371328	0.18	Dmrt1i	Dmrt1 interacting ncRNA	12619	0.16
chr9_13681735_13681905	0.18	Maml2	mastermind like transcriptional coactivator 2	19360	0.18
chr15_77928675_77928831	0.18	Txn2	thioredoxin 2	215	0.92
chr2_30545170_30545343	0.18	Gm14487	predicted gene 14487	10527	0.17
chr4_124682416_124682588	0.17	Utp11	UTP11 small subunit processome component	11032	0.09
chr2_122075180_122075331	0.17	Spg11	SPG11, spatacsin vesicle trafficking associated	43041	0.09
chr16_78371572_78371756	0.16	Btg3	BTG anti-proliferation factor 3	1672	0.33
chr16_7144291_7144454	0.16	Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	49375	0.2
chr2_119476960_119477373	0.16	Ino80	INO80 complex subunit	447	0.8
chr7_24850067_24850266	0.16	Gm18207	predicted gene, 18207	10780	0.08
chr3_97642273_97642480	0.16	Fmo5	flavin containing monooxygenase 5	13493	0.12
chr6_17463758_17464495	0.16	Met	met proto-oncogene	19	0.98
chr2_27675051_27675434	0.15	Rxra	retinoid X receptor alpha	1198	0.58
chr4_136675586_136676002	0.15	Ephb2	Eph receptor B2	14142	0.15
chr14_61125286_61125469	0.15	Sacs	sacsin	13080	0.21
chr2_152360517_152360697	0.15	Gm14165	predicted gene 14165	6992	0.09
chr1_153691155_153691333	0.15	Gm29529	predicted gene 29529	1412	0.3
chr5_127615097_127615417	0.15	Slc15a4	solute carrier family 15, member 4	1626	0.29
chr5_122239684_122239867	0.15	Tctn1	tectonic family member 1	11903	0.12
chrX_7422915_7423070	0.15	2010204K13Rik	RIKEN cDNA 2010204K13 gene	4	0.97
chr8_70395705_70396002	0.15	Crtc1	CREB regulated transcription coactivator 1	6945	0.12
chr19_43813317_43813611	0.15	Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	2942	0.21
chr5_114951424_114951834	0.15	2210016L21Rik	RIKEN cDNA 2210016L21 gene	5824	0.09
chr4_46868313_46868486	0.14	Gabbr2	gamma-aminobutyric acid (GABA) B receptor, 2	8497	0.27
chr12_73353785_73353952	0.14	Gm48653	predicted gene, 48653	1213	0.43
chr11_51859695_51859870	0.14	Jade2	jade family PHD finger 2	2129	0.29
chr5_146967227_146967378	0.14	Mtif3	mitochondrial translational initiation factor 3	3502	0.21
chr4_122977007_122977265	0.14	4933421A08Rik	RIKEN cDNA 4933421A08 gene	15827	0.12
chr15_55122695_55122962	0.14	Gm9920	predicted gene 9920	9151	0.15
chrX_60008756_60008925	0.14	F9	coagulation factor IX	9376	0.21
chr4_123960615_123960766	0.14	Gm12902	predicted gene 12902	34456	0.11
chr19_32524150_32524376	0.14	Gm36419	predicted gene, 36419	19085	0.15
chr8_71700006_71700195	0.14	B3gnt3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	1689	0.18
chr9_106447373_106447582	0.14	Abhd14b	abhydrolase domain containing 14b	18	0.49
chr3_138256816_138256967	0.14	Adh1	alcohol dehydrogenase 1 (class I)	4100	0.14
chr5_39219850_39220015	0.13	Gm40293	predicted gene, 40293	87152	0.08
chr7_141064386_141064940	0.13	B4galnt4	beta-1,4-N-acetyl-galactosaminyl transferase 4	169	0.88
chr5_100430036_100430187	0.13	Gm42690	predicted gene 42690	385	0.59
chrX_38423271_38423435	0.13	Lamp2	lysosomal-associated membrane protein 2	19797	0.15
chr12_54405210_54405378	0.13	Gm46328	predicted gene, 46328	5118	0.16
chr5_20704249_20704400	0.13	Magi2	membrane associated guanylate kinase, WW and PDZ domain containing 2	2655	0.3
chr19_57368390_57368551	0.13	Fam160b1	family with sequence similarity 160, member B1	7440	0.16
chr15_7154102_7154264	0.13	Lifr	LIF receptor alpha	170	0.97
chr15_39111986_39112168	0.12	Slc25a32	solute carrier family 25, member 32	555	0.51
chr11_116483917_116484077	0.12	Prpsap1	phosphoribosyl pyrophosphate synthetase-associated protein 1	5677	0.11
chr5_64114340_64114507	0.12	Pgm2	phosphoglucomutase 2	2322	0.2
chr1_153697619_153697798	0.12	Gm29529	predicted gene 29529	5052	0.13
chr10_42524541_42524692	0.12	Snx3	sorting nexin 3	22326	0.16
chr2_91242516_91242810	0.12	Ddb2	damage specific DNA binding protein 2	5681	0.11
chr18_68062225_68062529	0.12	Gm41764	predicted gene, 41764	55997	0.13
chr11_65131461_65131612	0.12	1700086D15Rik	RIKEN cDNA 1700086D15 gene	28354	0.12
chr10_44321957_44322108	0.12	Mir1929	microRNA 1929	37644	0.15
chr15_76594336_76594507	0.12	Adck5	aarF domain containing kinase 5	128	0.89
chr1_167746804_167746963	0.12	Lmx1a	LIM homeobox transcription factor 1 alpha	57326	0.15
chr8_70372073_70372256	0.11	Comp	cartilage oligomeric matrix protein	1394	0.28
chr11_120491297_120491754	0.11	Slc25a10	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10	315	0.64
chr2_120348240_120348405	0.11	Vps39	VPS39 HOPS complex subunit	4115	0.19
chr18_75502781_75502947	0.11	Gm10532	predicted gene 10532	11781	0.26
chr12_105000981_105001188	0.11	Syne3	spectrin repeat containing, nuclear envelope family member 3	2407	0.18
chr5_123023127_123023430	0.11	Orai1	ORAI calcium release-activated calcium modulator 1	7940	0.09
chr6_114918998_114919299	0.11	Vgll4	vestigial like family member 4	2668	0.32
chr6_100636259_100636566	0.11	Gm44108	predicted gene, 44108	9472	0.15
chr8_3277578_3277729	0.11	Insr	insulin receptor	1898	0.34
chr2_18543019_18543179	0.11	Gm13353	predicted gene 13353	25027	0.2
chr13_80894659_80894898	0.11	Arrdc3	arrestin domain containing 3	4260	0.19
chr16_33966526_33966697	0.11	Gm15829	predicted gene 15829	372	0.48
chr4_59438657_59438836	0.11	Susd1	sushi domain containing 1	113	0.97
chr16_52129443_52129606	0.11	Cblb	Casitas B-lineage lymphoma b	23002	0.21
chr11_99105971_99106266	0.10	Tns4	tensin 4	16812	0.14
chr11_101569721_101569872	0.10	Nbr1	NBR1, autophagy cargo receptor	1109	0.3
chr1_88411027_88411203	0.10	Spp2	secreted phosphoprotein 2	3709	0.2
chr4_6908644_6908795	0.10	Tox	thymocyte selection-associated high mobility group box	81764	0.11
chr1_168357153_168357454	0.10	Gm38381	predicted gene, 38381	6495	0.24
chr1_170815209_170815368	0.10	Gm25235	predicted gene, 25235	17583	0.12
chr17_34898174_34898489	0.10	C2	complement component 2 (within H-2S)	66	0.57
chr7_114461865_114462041	0.10	Pde3b	phosphodiesterase 3B, cGMP-inhibited	44225	0.15
chr8_62184095_62184246	0.10	Gm2961	predicted gene 2961	10042	0.27
chr5_111509539_111510088	0.10	C130026L21Rik	RIKEN cDNA C130026L21 gene	71609	0.09
chr12_31950204_31950930	0.10	Hbp1	high mobility group box transcription factor 1	32	0.98
chr1_52499794_52500020	0.10	Nab1	Ngfi-A binding protein 1	393	0.8
chr6_99145207_99145385	0.10	Foxp1	forkhead box P1	17722	0.26
chr7_81588668_81588888	0.10	Gm45698	predicted gene 45698	2116	0.19
chr2_35211769_35211922	0.09	Rab14	RAB14, member RAS oncogene family	10725	0.14
chr6_95163817_95164232	0.09	Kbtbd8	kelch repeat and BTB (POZ) domain containing 8	46040	0.12
chr3_35892773_35892978	0.09	Dcun1d1	DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae)	16970	0.12
chr8_120046377_120046540	0.09	Gm15684	predicted gene 15684	1171	0.4
chr8_13055180_13055331	0.09	Proz	protein Z, vitamin K-dependent plasma glycoprotein	5659	0.1
chr6_116015696_116015857	0.09	Plxnd1	plexin D1	20771	0.14
chr6_108662142_108662337	0.09	Bhlhe40	basic helix-loop-helix family, member e40	807	0.49
chr4_141452237_141452709	0.09	Zbtb17	zinc finger and BTB domain containing 17	7767	0.11
chr11_101700898_101701098	0.09	Dhx8	DEAH (Asp-Glu-Ala-His) box polypeptide 8	31921	0.08
chr2_3424682_3424836	0.09	Dclre1c	DNA cross-link repair 1C	557	0.63
chr18_61373998_61374172	0.08	Gm25301	predicted gene, 25301	23728	0.12
chr7_49351868_49352264	0.08	Gm44913	predicted gene 44913	5972	0.24
chr11_55468108_55468290	0.08	G3bp1	GTPase activating protein (SH3 domain) binding protein 1	1486	0.25
chr11_82852598_82853205	0.08	Rffl	ring finger and FYVE like domain containing protein	6809	0.12
chr2_48442189_48442365	0.08	Gm13481	predicted gene 13481	14968	0.23
chr9_54844002_54844168	0.08	Rab7-ps1	RAB7, member RAS oncogene family, pseudogene 1	18803	0.15
chr8_40907855_40908028	0.08	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	9503	0.16
chr3_32399514_32399821	0.08	Pik3ca	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	1996	0.29
chr9_18293076_18293227	0.08	Chordc1	cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1	763	0.59
chr19_40471969_40472156	0.08	Sorbs1	sorbin and SH3 domain containing 1	15493	0.2
chr6_144311505_144311701	0.08	Sox5	SRY (sex determining region Y)-box 5	102035	0.08
chr2_101831932_101832083	0.08	Prr5l	proline rich 5 like	6973	0.23
chr11_88181207_88181562	0.08	Cuedc1	CUE domain containing 1	919	0.56
chr18_33780213_33780407	0.08	Epb41l4aos	erythrocyte membrane protein band 4.1 like 4a, opposite strand	14582	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Clock

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.1	0.3	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.1	0.3	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
0.1	0.7	GO:0009992	cellular water homeostasis(GO:0009992)
0.0	0.4	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0061010	gall bladder development(GO:0061010)
0.0	0.1	GO:0036016	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.1	GO:0015755	fructose transport(GO:0015755)
0.0	0.1	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0	0.2	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.1	GO:0010915	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0	0.1	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.1	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.1	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0	0.8	GO:1903146	regulation of mitophagy(GO:1903146)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0050955	thermoception(GO:0050955)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.1	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.0	0.1	GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0015888	thiamine transport(GO:0015888)
0.0	0.1	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0	0.1	GO:0046049	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.0	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.0	GO:0036166	phenotypic switching(GO:0036166)
0.0	0.1	GO:0002408	myeloid dendritic cell chemotaxis(GO:0002408)
0.0	0.1	GO:0042414	epinephrine metabolic process(GO:0042414)
0.0	0.0	GO:0015744	succinate transport(GO:0015744)
0.0	0.1	GO:2000270	negative regulation of fibroblast apoptotic process(GO:2000270)
0.0	0.0	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:0006662	glycerol ether metabolic process(GO:0006662)
0.0	0.0	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.0	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.0	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	0.0	GO:0030167	proteoglycan catabolic process(GO:0030167)
0.0	0.0	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0	0.0	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.0	GO:0051031	tRNA transport(GO:0051031)
0.0	0.1	GO:0045324	late endosome to vacuole transport(GO:0045324)
0.0	0.0	GO:0009838	abscission(GO:0009838)
0.0	0.0	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.0	GO:0019087	transformation of host cell by virus(GO:0019087)
0.0	0.1	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.1	GO:0070166	enamel mineralization(GO:0070166)
0.0	0.0	GO:0048254	snoRNA localization(GO:0048254)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.3	GO:0001650	fibrillar center(GO:0001650)
0.0	0.1	GO:1990131	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	0.3	GO:0046930	pore complex(GO:0046930)
0.0	0.3	GO:0042101	T cell receptor complex(GO:0042101)
0.0	0.0	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.0	GO:0097441	basilar dendrite(GO:0097441)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.2	GO:0033743	peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.0	0.1	GO:0070061	fructose binding(GO:0070061)
0.0	0.1	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	0.0	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.0	0.7	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
0.0	0.0	GO:0015141	succinate transmembrane transporter activity(GO:0015141)
0.0	0.0	GO:0005502	11-cis retinal binding(GO:0005502)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.0	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.0	0.0	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.0	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.1	GO:0034902	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.0	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.8	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0	0.1	GO:0034211	GTP-dependent protein kinase activity(GO:0034211)
0.0	0.1	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.0	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.1	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.3	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling