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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Creb3

Z-value: 1.52

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Transcription factors associated with Creb3

Gene Symbol	Gene ID	Gene Info
Creb3 Ensembl NCBI MGI UniProt	ENSMUSG00000028466.9	cAMP responsive element binding protein 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr4_43562227_43562420	Creb3	9	0.567419	-0.80	5.7e-02	Click!
chr4_43564444_43564598	Creb3	1091	0.240966	0.13	8.1e-01	Click!

Activity of the Creb3 motif across conditions

Conditions sorted by the z-value of the Creb3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_106234042_106234256	2.47	Alas1	aminolevulinic acid synthase 1	2935	0.14
chr9_106238027_106238241	2.03	Alas1	aminolevulinic acid synthase 1	596	0.58
chr19_44405361_44405580	1.38	Scd1	stearoyl-Coenzyme A desaturase 1	1220	0.39
chr19_40184875_40185171	1.21	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	2263	0.24
chr1_153065706_153066077	1.20	Gm28960	predicted gene 28960	23616	0.16
chr17_46439216_46439478	1.15	Gm5093	predicted gene 5093	750	0.36
chr6_88084959_88085168	1.13	Rpn1	ribophorin I	500	0.72
chr9_122713984_122714139	1.10	Gm47136	predicted gene, 47136	272	0.8
chr15_6891349_6891647	1.01	Osmr	oncostatin M receptor	16529	0.26
chr12_44872872_44873043	0.99	Gm15901	predicted gene 15901	50223	0.16
chr6_136954835_136955023	0.97	Pde6h	phosphodiesterase 6H, cGMP-specific, cone, gamma	396	0.8
chr14_21033435_21033611	0.95	Vcl	vinculin	11520	0.18
chr10_68120534_68120685	0.89	Arid5b	AT rich interactive domain 5B (MRF1-like)	16017	0.23
chr11_28698214_28698534	0.89	2810471M01Rik	RIKEN cDNA 2810471M01 gene	16810	0.16
chr12_32707578_32707729	0.88	Gm18726	predicted gene, 18726	2508	0.33
chr3_129444766_129445057	0.87	Gm5712	predicted gene 5712	11238	0.17
chr8_125346149_125346401	0.87	Gm16237	predicted gene 16237	118952	0.06
chr11_120809069_120809447	0.87	Fasn	fatty acid synthase	443	0.66
chr3_121789937_121790142	0.85	4633401B06Rik	RIKEN cDNA 4633401B06 gene	1467	0.29
chr1_9578333_9578671	0.84	Gm6161	predicted gene 6161	3954	0.16
chr7_66106744_66106923	0.83	Chsy1	chondroitin sulfate synthase 1	2682	0.17
chr18_81319673_81319824	0.83	Gm30192	predicted gene, 30192	55040	0.14
chr19_44403590_44403745	0.79	Scd1	stearoyl-Coenzyme A desaturase 1	3023	0.2
chr9_42464439_42464590	0.77	Tbcel	tubulin folding cofactor E-like	3053	0.23
chr7_79278527_79278694	0.76	Gm44639	predicted gene 44639	843	0.51
chr9_122056710_122056883	0.76	Gm39465	predicted gene, 39465	5333	0.13
chr16_45377470_45377621	0.73	Cd200	CD200 antigen	22767	0.16
chr5_150270318_150270506	0.73	Fry	FRY microtubule binding protein	10645	0.18
chr9_60982764_60983106	0.72	Gm5122	predicted gene 5122	30546	0.14
chr17_31155739_31155923	0.72	Gm15318	predicted gene 15318	3035	0.15
chr15_7162840_7163002	0.71	Lifr	LIF receptor alpha	8568	0.27
chr13_101696929_101697112	0.71	Pik3r1	phosphoinositide-3-kinase regulatory subunit 1	2420	0.34
chr6_128362234_128363003	0.71	Rhno1	RAD9-HUS1-RAD1 interacting nuclear orphan 1	39	0.8
chr6_88503556_88503707	0.70	Gm44170	predicted gene, 44170	26	0.96
chr2_58780980_58781131	0.69	Upp2	uridine phosphorylase 2	15730	0.2
chr9_21367416_21367785	0.68	Ilf3	interleukin enhancer binding factor 3	271	0.81
chr19_44402814_44402965	0.68	Scd1	stearoyl-Coenzyme A desaturase 1	3801	0.18
chr13_107642431_107642610	0.67	Gm32090	predicted gene, 32090	29671	0.18
chr18_33436038_33436199	0.67	Nrep	neuronal regeneration related protein	27317	0.18
chr1_174876861_174877024	0.67	Grem2	gremlin 2, DAN family BMP antagonist	44877	0.19
chr1_8416665_8416825	0.67	Gm38024	predicted gene, 38024	36746	0.16
chr4_139631622_139632150	0.65	Aldh4a1	aldehyde dehydrogenase 4 family, member A1	8777	0.14
chr1_67223699_67224148	0.65	Gm15668	predicted gene 15668	25277	0.19
chr11_60197692_60198272	0.64	Mir6921	microRNA 6921	2635	0.16
chr4_47475007_47475158	0.63	Sec61b	Sec61 beta subunit	134	0.9
chr5_64298676_64298855	0.63	Tbc1d1	TBC1 domain family, member 1	235	0.91
chr15_89077248_89077417	0.62	Trabd	TraB domain containing	1208	0.24
chr2_11458006_11458188	0.61	Pfkfb3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3	24014	0.11
chr17_34024597_34024949	0.60	Ring1	ring finger protein 1	93	0.48
chr6_145857765_145857958	0.60	Gm43909	predicted gene, 43909	5436	0.18
chr6_66955153_66955330	0.60	Gm36816	predicted gene, 36816	53172	0.07
chr2_58771100_58771251	0.60	Upp2	uridine phosphorylase 2	5850	0.22
chr5_137918738_137918950	0.59	Cyp3a13	cytochrome P450, family 3, subfamily a, polypeptide 13	2775	0.12
chr3_27607549_27607727	0.59	Mir3092	microRNA 3092	22643	0.22
chr4_141858646_141858827	0.58	Ctrc	chymotrypsin C (caldecrin)	12377	0.1
chr3_148832133_148832284	0.58	Adgrl2	adhesion G protein-coupled receptor L2	1720	0.51
chr5_53999545_53999745	0.58	Stim2	stromal interaction molecule 2	1080	0.61
chr1_155596686_155596848	0.55	Acbd6	acyl-Coenzyme A binding domain containing 6	29519	0.19
chr1_60501628_60501779	0.54	Raph1	Ras association (RalGDS/AF-6) and pleckstrin homology domains 1	1562	0.34
chr18_12655181_12655597	0.54	Gm41668	predicted gene, 41668	6970	0.15
chr2_72741614_72741840	0.53	6430710C18Rik	RIKEN cDNA 6430710C18 gene	9126	0.22
chr4_148591704_148592085	0.53	Srm	spermidine synthase	24	0.95
chr11_69914167_69914731	0.53	Gps2	G protein pathway suppressor 2	257	0.73
chr7_6184467_6184618	0.52	Zfp444	zinc finger protein 444	966	0.36
chr5_135732561_135732712	0.52	Por	P450 (cytochrome) oxidoreductase	545	0.61
chr10_68137515_68137774	0.52	Arid5b	AT rich interactive domain 5B (MRF1-like)	1018	0.64
chr10_127042099_127042407	0.51	Mettl1	methyltransferase like 1	270	0.68
chr19_21271793_21272361	0.51	Zfand5	zinc finger, AN1-type domain 5	201	0.93
chr5_76946793_76946968	0.51	Ppat	phosphoribosyl pyrophosphate amidotransferase	4285	0.14
chr10_18107613_18107770	0.50	Reps1	RalBP1 associated Eps domain containing protein	3479	0.26
chr9_109875655_109876424	0.50	Cdc25a	cell division cycle 25A	99	0.94
chr9_106269146_106269548	0.50	Poc1a	POC1 centriolar protein A	11714	0.11
chr12_13248692_13249059	0.50	Ddx1	DEAD (Asp-Glu-Ala-Asp) box polypeptide 1	288	0.91
chr2_26445181_26445721	0.50	Sec16a	SEC16 homolog A, endoplasmic reticulum export factor	235	0.47
chr3_19067803_19068190	0.49	Gm37979	predicted gene, 37979	75903	0.1
chr8_41069792_41069999	0.48	Mtus1	mitochondrial tumor suppressor 1	12881	0.16
chr9_29220609_29220768	0.48	Ntm	neurotrimin	35023	0.24
chr9_102982126_102982356	0.48	Slco2a1	solute carrier organic anion transporter family, member 2a1	6471	0.18
chr15_59049309_59049466	0.48	Mtss1	MTSS I-BAR domain containing 1	6077	0.24
chr4_122981345_122981517	0.48	Mycl	v-myc avian myelocytomatosis viral oncogene lung carcinoma derived	14221	0.13
chr10_4612810_4612976	0.47	Esr1	estrogen receptor 1 (alpha)	872	0.66
chr11_3150287_3150471	0.47	Gm11400	predicted gene 11400	576	0.64
chr3_51231004_51231169	0.47	Gm38357	predicted gene, 38357	831	0.53
chr3_66122973_66123139	0.47	Tpi-rs2	triosephosphate isomerase related sequence 2	6667	0.14
chr2_155067847_155068055	0.47	Gm45609	predicted gene 45609	6230	0.14
chr1_13589326_13589477	0.47	Tram1	translocating chain-associating membrane protein 1	474	0.83
chr12_112125883_112126333	0.47	Mir203	microRNA 203	4772	0.13
chr14_118040435_118040621	0.47	Dct	dopachrome tautomerase	2601	0.27
chr17_27820677_27821072	0.46	Ilrun	inflammation and lipid regulator with UBA-like and NBR1-like domains	226	0.89
chr14_105176233_105176384	0.46	Rbm26	RNA binding motif protein 26	552	0.72
chr10_82838474_82838650	0.46	Txnrd1	thioredoxin reductase 1	4611	0.14
chr10_95434881_95435051	0.46	5730420D15Rik	RIKEN cDNA 5730420D15 gene	17591	0.11
chr8_22883020_22883183	0.45	Gm45555	predicted gene 45555	9512	0.16
chr1_59670602_59670909	0.45	Sumo1	small ubiquitin-like modifier 1	16	0.95
chr10_34280882_34281060	0.45	Tspyl1	testis-specific protein, Y-encoded-like 1	1219	0.32
chr3_144199004_144199155	0.45	Gm43445	predicted gene 43445	183	0.95
chr3_20154549_20155196	0.45	Gyg	glycogenin	197	0.95
chr18_5161126_5161309	0.45	Gm26682	predicted gene, 26682	4514	0.29
chr1_55007198_55007355	0.45	Sf3b1	splicing factor 3b, subunit 1	7917	0.16
chr3_18123890_18124104	0.44	Gm23686	predicted gene, 23686	53628	0.12
chr3_65391753_65392156	0.44	Ssr3	signal sequence receptor, gamma	599	0.62
chr10_125328331_125328708	0.44	Slc16a7	solute carrier family 16 (monocarboxylic acid transporters), member 7	16	0.98
chr15_27585587_27585755	0.44	Mir7117	microRNA 7117	14177	0.15
chr4_150704982_150705486	0.44	Gm16079	predicted gene 16079	26442	0.17
chr13_37993487_37993892	0.44	Ssr1	signal sequence receptor, alpha	15	0.98
chr11_94010166_94010510	0.44	Spag9	sperm associated antigen 9	14235	0.15
chr11_4232721_4232883	0.44	Gm11956	predicted gene 11956	1537	0.22
chr8_122376377_122376708	0.43	Zc3h18	zinc finger CCCH-type containing 18	67	0.94
chr15_85677948_85678118	0.43	Lncppara	long noncoding RNA near Ppara	24417	0.12
chr18_12729849_12730702	0.43	Ttc39c	tetratricopeptide repeat domain 39C	4430	0.15
chr8_76152377_76152560	0.43	Gm45742	predicted gene 45742	35441	0.19
chr11_70974084_70974259	0.43	Rpain	RPA interacting protein	569	0.58
chr12_69183702_69183869	0.43	Rpl36al	ribosomal protein L36A-like	201	0.62
chr4_53201741_53202070	0.43	4930412L05Rik	RIKEN cDNA 4930412L05 gene	15656	0.18
chr17_34122234_34122400	0.42	Brd2	bromodomain containing 2	283	0.55
chr4_143185627_143185923	0.42	Prdm2	PR domain containing 2, with ZNF domain	8960	0.14
chr4_76414713_76414880	0.42	Gm11252	predicted gene 11252	21642	0.2
chr11_16868019_16868198	0.42	Egfr	epidermal growth factor receptor	10042	0.2
chr15_65337961_65338116	0.42	Gm49242	predicted gene, 49242	137476	0.05
chr13_100731146_100731304	0.42	Cdk7	cyclin-dependent kinase 7	286	0.85
chr3_35963812_35963994	0.42	Mccc1	methylcrotonoyl-Coenzyme A carboxylase 1 (alpha)	2794	0.15
chr9_120492375_120492774	0.42	D830035M03Rik	RIKEN cDNA D830035M03 gene	27	0.55
chr14_61680870_61681697	0.42	Gm37472	predicted gene, 37472	211	0.83
chr8_122330590_122331113	0.42	Zfpm1	zinc finger protein, multitype 1	2847	0.17
chr11_116671796_116671995	0.41	Snhg16	small nucleolar RNA host gene 16	24	0.89
chr4_152040055_152040225	0.41	Nol9	nucleolar protein 9	777	0.43
chr10_4432270_4432710	0.41	Armt1	acidic residue methyltransferase 1	23	0.58
chr12_104856908_104857124	0.41	4930408O17Rik	RIKEN cDNA 4930408O17 gene	355	0.86
chr14_75844898_75845400	0.41	Tpt1	tumor protein, translationally-controlled 1	56	0.67
chr18_10735705_10735936	0.40	Mib1	mindbomb E3 ubiquitin protein ligase 1	9296	0.12
chr9_99167096_99167251	0.40	Pik3cb	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta	26552	0.13
chr13_74019761_74019928	0.40	Gm6263	predicted gene 6263	290	0.84
chr13_46583563_46583723	0.40	Cap2	CAP, adenylate cyclase-associated protein, 2 (yeast)	25871	0.16
chr19_55104348_55104714	0.40	Gpam	glycerol-3-phosphate acyltransferase, mitochondrial	1440	0.43
chr6_53125492_53125664	0.39	Gm8143	predicted gene 8143	46157	0.14
chr3_10022522_10022722	0.39	Gm38335	predicted gene, 38335	2917	0.22
chr18_31711636_31711807	0.39	Gm50060	predicted gene, 50060	26994	0.14
chr14_48058567_48058745	0.39	Gm49306	predicted gene, 49306	11645	0.15
chr19_8139266_8139472	0.39	Slc22a28	solute carrier family 22, member 28	7387	0.21
chr5_31094198_31094360	0.38	Slc30a3	solute carrier family 30 (zinc transporter), member 3	522	0.44
chr4_105313141_105313703	0.38	Gm12722	predicted gene 12722	61524	0.14
chr3_51255928_51256079	0.38	Elf2	E74-like factor 2	4238	0.15
chr11_58100366_58100593	0.38	Gm12247	predicted gene 12247	2706	0.16
chr13_48967094_48967659	0.38	Fam120a	family with sequence similarity 120, member A	641	0.78
chr8_72134846_72135406	0.38	Tpm4	tropomyosin 4	103	0.92
chr4_61740192_61740453	0.38	Gm12573	predicted gene 12573	9753	0.14
chr8_24506282_24506451	0.38	9130214F15Rik	RIKEN cDNA 9130214F15 gene	64	0.97
chr6_48546645_48546917	0.38	Lrrc61	leucine rich repeat containing 61	8015	0.07
chr3_52708989_52709165	0.38	Gm22798	predicted gene, 22798	13678	0.2
chr9_44079482_44079643	0.37	Usp2	ubiquitin specific peptidase 2	5377	0.08
chr15_59067650_59068255	0.37	Mtss1	MTSS I-BAR domain containing 1	12488	0.22
chr4_60380015_60380268	0.37	Mup-ps29	major urinary protein, pseudogene 29	4353	0.18
chr14_21258806_21259018	0.37	Adk	adenosine kinase	59213	0.14
chr8_61273697_61273901	0.37	1700001D01Rik	RIKEN cDNA 1700001D01 gene	15073	0.2
chr4_108091724_108091875	0.37	Mir6397	microRNA 6397	4442	0.16
chr5_33637715_33637883	0.37	Slbp	stem-loop binding protein	4363	0.12
chr2_144369139_144369688	0.37	Kat14	lysine acetyltransferase 14	414	0.43
chr4_61401423_61401691	0.37	Mup15	major urinary protein 15	38186	0.14
chr2_31473064_31473684	0.37	Ass1	argininosuccinate synthetase 1	3167	0.24
chr15_102103356_102103597	0.37	Tns2	tensin 2	488	0.69
chr4_150910161_150910368	0.36	Park7	Parkinson disease (autosomal recessive, early onset) 7	338	0.85
chr3_18150886_18151037	0.36	Gm23686	predicted gene, 23686	26664	0.2
chr11_63851634_63851785	0.36	Hmgb1-ps3	high mobility group box 1, pseudogene 3	4891	0.25
chr1_134556289_134556846	0.36	Kdm5b	lysine (K)-specific demethylase 5B	3604	0.15
chr2_132247543_132247890	0.36	Tmem230	transmembrane protein 230	40	0.96
chr2_94144685_94145031	0.36	Hsd17b12	hydroxysteroid (17-beta) dehydrogenase 12	13035	0.17
chr6_108498342_108498493	0.36	Itpr1	inositol 1,4,5-trisphosphate receptor 1	4615	0.17
chr14_120368517_120368700	0.35	Mbnl2	muscleblind like splicing factor 2	10633	0.23
chr15_76227819_76227970	0.35	Plec	plectin	1603	0.17
chr4_101742085_101742265	0.35	Lepr	leptin receptor	24768	0.19
chr9_106369294_106369462	0.35	Dusp7	dual specificity phosphatase 7	234	0.89
chr13_48780406_48780581	0.35	Rpl17-ps6	ribosomal protein L17, pseudogene 6	16912	0.21
chr4_101352284_101352479	0.35	0610043K17Rik	RIKEN cDNA 0610043K17 gene	1402	0.26
chr4_118544058_118544229	0.35	Tmem125	transmembrane protein 125	99	0.95
chr15_8446418_8446615	0.35	Nipbl	NIPBL cohesin loading factor	2053	0.29
chr11_6029193_6029353	0.35	Camk2b	calcium/calmodulin-dependent protein kinase II, beta	28825	0.14
chr19_27523352_27523503	0.35	Gm50101	predicted gene, 50101	10919	0.27
chr4_103934236_103934436	0.35	Gm12719	predicted gene 12719	5205	0.26
chr2_174331207_174331414	0.34	Gnas	GNAS (guanine nucleotide binding protein, alpha stimulating) complex locus	1023	0.46
chr15_97042042_97042238	0.34	Slc38a4	solute carrier family 38, member 4	7947	0.28
chr5_121545742_121546093	0.34	Mapkapk5	MAP kinase-activated protein kinase 5	12	0.79
chr12_83793099_83793274	0.34	Papln	papilin, proteoglycan-like sulfated glycoprotein	29524	0.09
chr17_87613426_87613601	0.34	Epcam	epithelial cell adhesion molecule	22466	0.16
chr5_28317905_28318134	0.34	Rbm33	RNA binding motif protein 33	817	0.71
chr2_84995821_84996178	0.34	Prg3	proteoglycan 3	7784	0.12
chr2_119155467_119155649	0.34	Rmdn3	regulator of microtubule dynamics 3	1266	0.29
chr3_51252801_51253044	0.34	Elf2	E74-like factor 2	7319	0.13
chr5_143404756_143404931	0.33	Kdelr2	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2	1005	0.26
chr1_160991824_160991975	0.33	Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	2522	0.1
chr18_46597468_46597778	0.33	Eif1a	eukaryotic translation initiation factor 1A	78	0.5
chr1_51644548_51644705	0.33	Gm17767	predicted gene, 17767	47908	0.14
chr6_91473855_91474394	0.33	Tmem43	transmembrane protein 43	365	0.58
chr14_11132816_11133186	0.33	Fhit	fragile histidine triad gene	7410	0.24
chr2_5036536_5036703	0.33	Optn	optineurin	578	0.46
chr8_79367434_79367595	0.32	Smad1	SMAD family member 1	10836	0.18
chr13_37992728_37992914	0.32	Ssr1	signal sequence receptor, alpha	883	0.58
chr7_19877096_19877247	0.32	Gm44659	predicted gene 44659	5733	0.08
chr17_31905801_31906170	0.32	2310015A16Rik	RIKEN cDNA 2310015A16 gene	3044	0.18
chr11_97782368_97782528	0.32	Rpl23	ribosomal protein L23	11	0.89
chr13_24317333_24317604	0.32	Gm23340	predicted gene, 23340	616	0.57

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.0	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.2	0.7	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.2	0.5	GO:0000087	mitotic M phase(GO:0000087)
0.2	0.3	GO:1901671	positive regulation of superoxide dismutase activity(GO:1901671) positive regulation of removal of superoxide radicals(GO:1904833)
0.1	0.6	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.1	0.8	GO:1901894	regulation of calcium-transporting ATPase activity(GO:1901894)
0.1	0.5	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.4	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.5	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.1	0.3	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.1	0.4	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.1	0.3	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.1	0.4	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.1	1.7	GO:0006783	heme biosynthetic process(GO:0006783)
0.1	0.2	GO:2000384	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.1	0.4	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.1	0.2	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.1	0.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.1	0.1	GO:0006543	glutamine catabolic process(GO:0006543)
0.1	0.1	GO:0046084	adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.1	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.1	0.1	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.1	0.2	GO:0070827	chromatin maintenance(GO:0070827)
0.1	0.2	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.1	0.2	GO:0034628	nicotinamide nucleotide biosynthetic process from aspartate(GO:0019355) 'de novo' NAD biosynthetic process from aspartate(GO:0034628)
0.1	0.5	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1	0.2	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.1	0.1	GO:0055099	response to high density lipoprotein particle(GO:0055099)
0.1	0.2	GO:0006824	cobalt ion transport(GO:0006824)
0.1	0.1	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.1	0.2	GO:0003162	atrioventricular node development(GO:0003162)
0.1	0.4	GO:0090400	stress-induced premature senescence(GO:0090400)
0.1	0.2	GO:0014022	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.1	0.3	GO:0071763	nuclear membrane organization(GO:0071763)
0.1	0.6	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.1	0.2	GO:0033132	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.1	0.2	GO:0033387	putrescine biosynthetic process(GO:0009446) putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.1	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.0	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:0060244	negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0	0.2	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.0	0.4	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.4	GO:0006388	tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0	0.3	GO:0032532	regulation of microvillus length(GO:0032532)
0.0	0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.2	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.0	0.7	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.2	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.1	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.1	GO:0030070	insulin processing(GO:0030070)
0.0	0.1	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.0	0.2	GO:2001137	positive regulation of endocytic recycling(GO:2001137)
0.0	0.1	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.1	GO:0002439	chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0	0.1	GO:0090579	transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.0	0.1	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.0	0.2	GO:0035795	negative regulation of mitochondrial membrane permeability(GO:0035795)
0.0	0.1	GO:2000359	regulation of binding of sperm to zona pellucida(GO:2000359)
0.0	0.2	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	0.1	GO:0014732	skeletal muscle atrophy(GO:0014732)
0.0	0.2	GO:0090205	positive regulation of cholesterol biosynthetic process(GO:0045542) positive regulation of cholesterol metabolic process(GO:0090205)
0.0	0.2	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.2	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.0	GO:0006046	N-acetylglucosamine catabolic process(GO:0006046)
0.0	0.3	GO:0072502	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0061010	gall bladder development(GO:0061010)
0.0	0.7	GO:0045742	positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.0	0.1	GO:1900107	regulation of nodal signaling pathway(GO:1900107)
0.0	0.0	GO:0034627	'de novo' NAD biosynthetic process(GO:0034627)
0.0	0.2	GO:0060613	fat pad development(GO:0060613)
0.0	0.3	GO:0032486	Rap protein signal transduction(GO:0032486)
0.0	0.1	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.1	GO:0010520	regulation of reciprocal meiotic recombination(GO:0010520)
0.0	0.1	GO:0006868	glutamine transport(GO:0006868)
0.0	0.2	GO:0019856	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.2	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.0	0.2	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.1	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.2	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.3	GO:0042996	regulation of Golgi to plasma membrane protein transport(GO:0042996)
0.0	0.1	GO:0046469	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.1	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0	0.7	GO:0071353	cellular response to interleukin-4(GO:0071353)
0.0	0.2	GO:0009186	deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.2	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.2	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.1	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.2	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.1	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.0	0.1	GO:1903347	negative regulation of bicellular tight junction assembly(GO:1903347)
0.0	0.1	GO:0070346	positive regulation of fat cell proliferation(GO:0070346)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.2	GO:0035437	maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0	0.1	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.1	GO:0018214	protein carboxylation(GO:0018214)
0.0	0.1	GO:1902996	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.1	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.1	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.1	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0	0.1	GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998)
0.0	0.1	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.0	0.1	GO:0097155	fasciculation of sensory neuron axon(GO:0097155)
0.0	0.1	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.1	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.1	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0	0.1	GO:1904017	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.1	GO:0022417	protein maturation by protein folding(GO:0022417)
0.0	0.1	GO:0031049	programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.0	0.1	GO:0070384	Harderian gland development(GO:0070384)
0.0	0.2	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0	0.1	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.1	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.1	GO:0021553	olfactory nerve development(GO:0021553)
0.0	0.1	GO:1903887	motile primary cilium assembly(GO:1903887)
0.0	0.1	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0071372	cellular response to follicle-stimulating hormone stimulus(GO:0071372)
0.0	0.1	GO:0009158	ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.0	0.1	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.1	GO:0060527	prostate glandular acinus morphogenesis(GO:0060526) prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis(GO:0060527)
0.0	0.0	GO:0010643	cell communication by chemical coupling(GO:0010643)
0.0	0.1	GO:2000210	positive regulation of anoikis(GO:2000210)
0.0	0.1	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0	0.3	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0010887	negative regulation of cholesterol storage(GO:0010887)
0.0	0.2	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.0	0.2	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.3	GO:0000479	endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000479)
0.0	0.1	GO:0021873	forebrain neuroblast division(GO:0021873)
0.0	0.0	GO:0003195	tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195)
0.0	0.1	GO:0019287	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.1	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.2	GO:0070131	positive regulation of mitochondrial translation(GO:0070131)
0.0	0.2	GO:0030206	chondroitin sulfate biosynthetic process(GO:0030206)
0.0	0.1	GO:0035522	monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0	0.2	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.4	GO:0014850	response to muscle activity(GO:0014850)
0.0	0.3	GO:0042026	protein refolding(GO:0042026)
0.0	0.0	GO:0003308	negative regulation of Wnt signaling pathway involved in heart development(GO:0003308)
0.0	0.5	GO:0048745	smooth muscle tissue development(GO:0048745)
0.0	0.1	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.0	0.3	GO:0014041	regulation of neuron maturation(GO:0014041)
0.0	0.2	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.0	GO:1990791	dorsal root ganglion development(GO:1990791)
0.0	0.1	GO:0061038	uterus morphogenesis(GO:0061038)
0.0	0.2	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0061144	alveolar secondary septum development(GO:0061144)
0.0	0.1	GO:0042663	regulation of endodermal cell fate specification(GO:0042663)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:2001256	regulation of store-operated calcium entry(GO:2001256)
0.0	0.1	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	0.1	GO:0052405	negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0	0.2	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.1	GO:0051106	regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.0	0.1	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.1	GO:1903898	negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.7	GO:0045071	negative regulation of viral genome replication(GO:0045071)
0.0	0.1	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0	0.0	GO:0035754	B cell chemotaxis(GO:0035754)
0.0	0.0	GO:0060125	negative regulation of growth hormone secretion(GO:0060125)
0.0	0.1	GO:0060509	Type I pneumocyte differentiation(GO:0060509)
0.0	0.3	GO:2000001	regulation of DNA damage checkpoint(GO:2000001)
0.0	0.0	GO:0002215	defense response to nematode(GO:0002215)
0.0	0.0	GO:0046098	guanine metabolic process(GO:0046098)
0.0	0.0	GO:0010603	regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0	0.1	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.1	GO:0030916	otic vesicle formation(GO:0030916)
0.0	0.1	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0	0.5	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0	0.1	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.1	GO:0043174	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097) nucleoside salvage(GO:0043174)
0.0	0.0	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.1	GO:1900060	negative regulation of ceramide biosynthetic process(GO:1900060)
0.0	0.0	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.1	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0	0.1	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.1	GO:0021540	corpus callosum morphogenesis(GO:0021540)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0090154	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.2	GO:0007095	mitotic G2 DNA damage checkpoint(GO:0007095)
0.0	0.0	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.0	0.0	GO:0044375	regulation of peroxisome size(GO:0044375)
0.0	0.1	GO:0042091	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.0	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.0	0.3	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.1	GO:2000781	positive regulation of double-strand break repair(GO:2000781)
0.0	0.1	GO:0000103	sulfate assimilation(GO:0000103)
0.0	0.0	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.1	GO:0042759	long-chain fatty acid biosynthetic process(GO:0042759)
0.0	0.4	GO:0046329	negative regulation of JNK cascade(GO:0046329)
0.0	0.1	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.0	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.4	GO:0000027	ribosomal large subunit assembly(GO:0000027)
0.0	0.0	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0	0.1	GO:0022615	protein to membrane docking(GO:0022615)
0.0	0.1	GO:0090427	activation of meiosis(GO:0090427)
0.0	0.0	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.0	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.5	GO:0071479	cellular response to ionizing radiation(GO:0071479)
0.0	0.2	GO:0043923	positive regulation by host of viral transcription(GO:0043923)
0.0	0.0	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.3	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.0	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.0	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.1	GO:0032466	negative regulation of cytokinesis(GO:0032466)
0.0	0.1	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0	0.4	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.0	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.2	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0033227	dsRNA transport(GO:0033227)
0.0	0.0	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.1	GO:2000980	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.4	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0070129	regulation of mitochondrial translation(GO:0070129)
0.0	0.0	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.0	GO:0035459	cargo loading into vesicle(GO:0035459)
0.0	0.2	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.2	GO:0071577	zinc II ion transmembrane transport(GO:0071577)
0.0	0.0	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
0.0	0.0	GO:0060279	positive regulation of ovulation(GO:0060279)
0.0	0.0	GO:0036015	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.0	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.0	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.0	GO:0044333	planar cell polarity pathway involved in axis elongation(GO:0003402) Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0	0.0	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.0	0.0	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.0	GO:1904684	negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
0.0	0.1	GO:0033182	regulation of histone ubiquitination(GO:0033182)
0.0	0.0	GO:0072610	interleukin-12 secretion(GO:0072610)
0.0	0.0	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.1	GO:0090160	Golgi to lysosome transport(GO:0090160)
0.0	0.1	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.0	GO:0021943	formation of radial glial scaffolds(GO:0021943)
0.0	0.0	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:1901620	regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901620)
0.0	0.0	GO:0001887	selenium compound metabolic process(GO:0001887)
0.0	0.0	GO:0010288	response to lead ion(GO:0010288)
0.0	0.0	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.1	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.1	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.0	GO:1903894	regulation of IRE1-mediated unfolded protein response(GO:1903894)
0.0	0.0	GO:0002025	vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0	0.1	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.0	0.2	GO:0008608	attachment of spindle microtubules to kinetochore(GO:0008608)
0.0	0.0	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.0	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.0	0.1	GO:0060766	negative regulation of androgen receptor signaling pathway(GO:0060766)
0.0	0.0	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.0	0.0	GO:1990123	L-glutamate(1-) import into cell(GO:1903802) L-glutamate import into cell(GO:1990123)
0.0	0.1	GO:0070431	nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0	0.1	GO:0006458	'de novo' protein folding(GO:0006458) 'de novo' posttranslational protein folding(GO:0051084)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.0	0.2	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0043654	recognition of apoptotic cell(GO:0043654)
0.0	0.0	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.0	GO:0032202	telomere assembly(GO:0032202)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.0	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.0	0.3	GO:0000060	protein import into nucleus, translocation(GO:0000060)
0.0	0.3	GO:0018196	peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.2	GO:0061049	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0	0.1	GO:1904251	regulation of bile acid metabolic process(GO:1904251)
0.0	0.1	GO:0002097	tRNA wobble base modification(GO:0002097)
0.0	0.1	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.0	0.1	GO:0045836	positive regulation of meiotic nuclear division(GO:0045836)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.5	GO:0006334	nucleosome assembly(GO:0006334)
0.0	0.0	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.1	GO:0046051	UTP metabolic process(GO:0046051)
0.0	0.1	GO:0071557	histone H3-K27 demethylation(GO:0071557)
0.0	0.0	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.0	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.0	GO:0034137	positive regulation of toll-like receptor 2 signaling pathway(GO:0034137)
0.0	0.0	GO:0007066	female meiosis sister chromatid cohesion(GO:0007066)
0.0	0.0	GO:1900364	negative regulation of mRNA polyadenylation(GO:1900364)
0.0	0.0	GO:0051295	establishment of meiotic spindle localization(GO:0051295)
0.0	0.0	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:0042921	glucocorticoid receptor signaling pathway(GO:0042921)
0.0	0.0	GO:0032788	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.0	GO:0010387	COP9 signalosome assembly(GO:0010387)
0.0	0.1	GO:0050917	sensory perception of umami taste(GO:0050917)
0.0	0.1	GO:0051026	chiasma assembly(GO:0051026)
0.0	0.1	GO:0061157	mRNA destabilization(GO:0061157)
0.0	0.2	GO:0048599	oocyte development(GO:0048599)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1	0.4	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	0.3	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.1	0.9	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.1	0.4	GO:0045298	tubulin complex(GO:0045298)
0.1	0.4	GO:0070876	SOSS complex(GO:0070876)
0.1	0.4	GO:0005579	membrane attack complex(GO:0005579)
0.1	0.2	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.1	0.6	GO:0042587	glycogen granule(GO:0042587)
0.1	0.2	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.1	0.5	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.1	0.4	GO:0001739	sex chromatin(GO:0001739)
0.1	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.2	GO:0020016	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.1	0.5	GO:0001650	fibrillar center(GO:0001650)
0.1	0.2	GO:0036449	microtubule minus-end(GO:0036449)
0.1	0.3	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.3	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.1	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.1	GO:1990812	growth cone filopodium(GO:1990812)
0.0	0.1	GO:0070939	Dsl1p complex(GO:0070939)
0.0	0.2	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.3	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.6	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.2	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.1	GO:0005610	laminin-5 complex(GO:0005610)
0.0	0.1	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.2	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.3	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.1	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.2	GO:0071437	invadopodium(GO:0071437)
0.0	0.4	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.0	GO:0032010	phagolysosome(GO:0032010)
0.0	0.1	GO:0048476	Holliday junction resolvase complex(GO:0048476)
0.0	0.1	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.1	GO:0033553	rDNA heterochromatin(GO:0033553)
0.0	0.1	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.1	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.2	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.1	GO:0043293	apoptosome(GO:0043293)
0.0	0.2	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0030312	external encapsulating structure(GO:0030312)
0.0	0.3	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0001652	granular component(GO:0001652)
0.0	0.1	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.2	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.1	GO:0071797	LUBAC complex(GO:0071797)
0.0	0.1	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.1	GO:0000835	ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0	0.1	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.0	GO:0097443	sorting endosome(GO:0097443)
0.0	0.2	GO:0071564	npBAF complex(GO:0071564)
0.0	0.2	GO:0033646	host cell cytoplasm(GO:0030430) host intracellular part(GO:0033646) host cell cytoplasm part(GO:0033655) intracellular region of host(GO:0043656)
0.0	0.3	GO:0043034	costamere(GO:0043034)
0.0	0.1	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	1.1	GO:0017053	transcriptional repressor complex(GO:0017053)
0.0	1.0	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.1	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.0	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0033503	HULC complex(GO:0033503)
0.0	0.1	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.0	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306)
0.0	0.1	GO:0035339	SPOTS complex(GO:0035339)
0.0	0.0	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.1	GO:0044530	supraspliceosomal complex(GO:0044530)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.0	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.7	GO:0016605	PML body(GO:0016605)
0.0	0.2	GO:0031045	dense core granule(GO:0031045)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.1	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.0	GO:0031298	replication fork protection complex(GO:0031298)
0.0	0.1	GO:0005652	nuclear lamina(GO:0005652)
0.0	0.0	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.0	GO:0097513	myosin II filament(GO:0097513)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.6	GO:0016420	S-malonyltransferase activity(GO:0016419) malonyltransferase activity(GO:0016420)
0.3	0.8	GO:0048408	epidermal growth factor binding(GO:0048408)
0.3	1.0	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.2	0.7	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.2	0.5	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.4	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1	0.9	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1	0.4	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.4	GO:0045340	mercury ion binding(GO:0045340)
0.1	0.5	GO:0043426	MRF binding(GO:0043426)
0.1	0.3	GO:0034056	estrogen response element binding(GO:0034056)
0.1	0.2	GO:0004779	sulfate adenylyltransferase activity(GO:0004779)
0.1	0.2	GO:0061731	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.1	0.4	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.1	0.2	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1	0.9	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1	0.2	GO:0097109	neuroligin family protein binding(GO:0097109)
0.1	0.2	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.1	0.2	GO:0000309	nicotinamide-nucleotide adenylyltransferase activity(GO:0000309) nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
0.1	0.3	GO:0004340	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.1	0.4	GO:0005536	glucose binding(GO:0005536)
0.1	0.3	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1	0.4	GO:0033677	DNA/RNA helicase activity(GO:0033677)
0.1	0.4	GO:0035197	siRNA binding(GO:0035197)
0.1	1.7	GO:0016749	N-succinyltransferase activity(GO:0016749)
0.1	0.3	GO:0004523	RNA-DNA hybrid ribonuclease activity(GO:0004523)
0.0	0.2	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.4	GO:0031386	protein tag(GO:0031386)
0.0	0.2	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.2	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.8	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0070191	methionine-R-sulfoxide reductase activity(GO:0070191)
0.0	0.4	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180)
0.0	0.1	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.1	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.3	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.0	0.0	GO:0016662	oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0070878	primary miRNA binding(GO:0070878)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.2	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.2	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.4	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.2	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0030620	U2 snRNA binding(GO:0030620)
0.0	0.1	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.2	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.2	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.6	GO:0019206	nucleoside kinase activity(GO:0019206)
0.0	0.1	GO:0038100	nodal binding(GO:0038100)
0.0	0.2	GO:0051011	microtubule minus-end binding(GO:0051011)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.1	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.2	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.0	0.0	GO:0016748	succinyltransferase activity(GO:0016748)
0.0	0.3	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.2	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0	0.1	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.2	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.0	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0036033	mediator complex binding(GO:0036033)
0.0	0.1	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.2	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.2	GO:1990247	N6-methyladenosine-containing RNA binding(GO:1990247)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.0	0.1	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.1	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	0.2	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0015186	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.2	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0008499	UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
0.0	0.0	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0	0.2	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.3	GO:0001618	virus receptor activity(GO:0001618)
0.0	0.1	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0	0.1	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0	0.1	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.1	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.0	0.0	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)
0.0	0.4	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0031544	peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.6	GO:0017017	MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.0	0.1	GO:0031781	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.1	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.3	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0	0.2	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.2	GO:0004787	thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.1	GO:0016615	malate dehydrogenase activity(GO:0016615)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.2	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.1	GO:0004690	cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.0	0.1	GO:0036122	BMP binding(GO:0036122)
0.0	0.4	GO:0015347	sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0	0.2	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.0	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.2	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.0	GO:0035276	alcohol dehydrogenase activity, zinc-dependent(GO:0004024) ethanol binding(GO:0035276)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.3	GO:0005537	mannose binding(GO:0005537)
0.0	0.0	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.1	GO:0061665	SUMO ligase activity(GO:0061665)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0034040	lipid-transporting ATPase activity(GO:0034040)
0.0	0.0	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.1	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0	0.0	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.5	GO:0005109	frizzled binding(GO:0005109)
0.0	0.2	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.1	GO:0071558	histone demethylase activity (H3-K27 specific)(GO:0071558)
0.0	0.1	GO:0000150	recombinase activity(GO:0000150)
0.0	0.1	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.0	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.0	GO:0089720	caspase binding(GO:0089720)
0.0	0.0	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.0	0.1	GO:0016671	oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.0	0.1	GO:0071253	connexin binding(GO:0071253)
0.0	0.2	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.3	GO:0016676	cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0	0.2	GO:0042800	histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0	0.0	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.0	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.0	GO:1990188	euchromatin binding(GO:1990188)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.0	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0034942	acyl-CoA ligase activity(GO:0003996) 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0	0.1	GO:0003720	telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.0	0.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.0	GO:0002046	opsin binding(GO:0002046)
0.0	0.2	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.5	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.0	0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.0	GO:0001016	RNA polymerase III regulatory region DNA binding(GO:0001016)
0.0	0.1	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.0	0.0	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.0	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.6	GO:0051082	unfolded protein binding(GO:0051082)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1	1.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	0.5	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.0	1.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.5	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.6	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.9	PID FOXO PATHWAY	FoxO family signaling
0.0	0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.2	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.1	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.5	PID PLK1 PATHWAY	PLK1 signaling events
0.0	0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0	0.2	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.0	0.1	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.0	0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.0	0.2	PID ATR PATHWAY	ATR signaling pathway
0.0	0.6	PID P73PATHWAY	p73 transcription factor network
0.0	0.4	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	0.4	PID P53 REGULATION PATHWAY	p53 pathway
0.0	0.3	PID ATM PATHWAY	ATM pathway
0.0	0.3	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling
0.0	0.3	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	0.2	PID VEGFR1 PATHWAY	VEGFR1 specific signals

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.6	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.1	0.2	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.1	0.9	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.1	0.6	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.1	0.6	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.4	REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
0.0	0.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.0	0.5	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	3.4	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0	0.4	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.0	REACTOME MITOTIC M M G1 PHASES	Genes involved in Mitotic M-M/G1 phases
0.0	0.7	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	0.3	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.3	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.5	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.0	0.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.1	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.2	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.3	REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS	Genes involved in Synthesis of substrates in N-glycan biosythesis
0.0	0.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.2	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0	0.3	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.2	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
0.0	0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.2	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.3	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.0	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.4	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.1	REACTOME PYRIMIDINE METABOLISM	Genes involved in Pyrimidine metabolism
0.0	0.2	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	0.1	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.0	0.2	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.0	0.0	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.0	0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism

Results for Creb3

Z-value: 1.52

Motif logo

Transcription factors associated with Creb3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Creb3 motif across conditions

Conditions sorted by the z-value of the Creb3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Creb3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: