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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Crx_Gsc

Z-value: 0.96

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Transcription factors associated with Crx_Gsc

Gene Symbol	Gene ID	Gene Info
Crx Ensembl NCBI MGI UniProt	ENSMUSG00000041578.9	Crx
Gsc Ensembl NCBI MGI UniProt	ENSMUSG00000021095.4	Gsc

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Gsc	chr12_104448270_104448434	24978	0.112130	-0.52	2.9e-01	Click!
Gsc	chr12_104467528_104467691	5721	0.154405	0.40	4.3e-01	Click!
Gsc	chr12_104454871_104455035	18377	0.125087	-0.10	8.5e-01	Click!

Activity of the Crx_Gsc motif across conditions

Conditions sorted by the z-value of the Crx_Gsc motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_19452656_19452840	0.84	Gm33104	predicted gene, 33104	33967	0.17
chr17_63010676_63010827	0.81	Gm25348	predicted gene, 25348	86249	0.1
chr11_16854254_16854692	0.76	Egfr	epidermal growth factor receptor	23677	0.17
chr3_62404931_62405082	0.76	Arhgef26	Rho guanine nucleotide exchange factor (GEF) 26	14662	0.25
chr12_104343910_104344587	0.73	Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	5762	0.12
chr7_4815487_4815639	0.66	Ube2s	ubiquitin-conjugating enzyme E2S	2973	0.11
chr3_89147086_89147561	0.57	Hcn3	hyperpolarization-activated, cyclic nucleotide-gated K+ 3	3891	0.08
chr19_18145861_18146289	0.56	Gm18610	predicted gene, 18610	59720	0.14
chr17_57206582_57206733	0.56	Mir6978	microRNA 6978	10571	0.1
chr6_51720326_51720477	0.55	Gm38811	predicted gene, 38811	9320	0.26
chr11_16906555_16906817	0.55	Egfr	epidermal growth factor receptor	1501	0.41
chr11_16873480_16873631	0.52	Egfr	epidermal growth factor receptor	4595	0.23
chr9_74791375_74791538	0.51	Gm22315	predicted gene, 22315	9386	0.19
chr19_8835906_8836201	0.49	Bscl2	Berardinelli-Seip congenital lipodystrophy 2 (seipin)	1414	0.13
chr11_16901525_16901732	0.48	Egfr	epidermal growth factor receptor	3557	0.24
chr11_5909584_5909735	0.48	Gck	glucokinase	5465	0.12
chr9_106236583_106237078	0.47	Alas1	aminolevulinic acid synthase 1	254	0.85
chr12_87443142_87443299	0.47	Alkbh1	alkB homolog 1, histone H2A dioxygenase	606	0.34
chr1_88048809_88049389	0.46	Ugt1a10	UDP glycosyltransferase 1 family, polypeptide A10	6289	0.08
chr17_64643456_64643864	0.46	Man2a1	mannosidase 2, alpha 1	42924	0.17
chr18_81199291_81199673	0.45	4930594M17Rik	RIKEN cDNA 4930594M17 gene	36584	0.17
chr4_63229865_63230144	0.44	Col27a1	collagen, type XXVII, alpha 1	4282	0.2
chr2_134489871_134490022	0.44	Hao1	hydroxyacid oxidase 1, liver	64361	0.14
chr15_7201530_7201687	0.44	Egflam	EGF-like, fibronectin type III and laminin G domains	21461	0.23
chr8_40657023_40657174	0.43	Adam24	a disintegrin and metallopeptidase domain 24 (testase 1)	17979	0.13
chr8_125349423_125349587	0.42	Gm16237	predicted gene 16237	122182	0.05
chr2_72207332_72207483	0.42	Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4	8608	0.18
chr15_7189723_7189941	0.41	Egflam	EGF-like, fibronectin type III and laminin G domains	33237	0.19
chr6_86699596_86699790	0.41	Gm44214	predicted gene, 44214	11265	0.1
chr1_88064051_88064407	0.41	AC087801.2	UDP glucuronosyltransferase 1 family, polypeptide A9 (Ugt1a9), pseudogene	3105	0.1
chr19_31884765_31884939	0.40	A1cf	APOBEC1 complementation factor	16071	0.21
chr5_23562685_23562882	0.40	Srpk2	serine/arginine-rich protein specific kinase 2	13413	0.19
chr12_35681929_35682122	0.40	9130015A21Rik	RIKEN cDNA 9130015A21 gene	4279	0.24
chr1_168682011_168682173	0.40	1700063I16Rik	RIKEN cDNA 1700063I16 gene	6210	0.33
chr9_74672657_74672818	0.40	Gm27233	predicted gene 27233	36525	0.18
chr17_86552135_86552300	0.40	Gm10309	predicted gene 10309	46985	0.15
chr11_16782319_16782716	0.38	Egfr	epidermal growth factor receptor	30287	0.16
chr11_16849295_16849477	0.38	Egfros	epidermal growth factor receptor, opposite strand	18684	0.19
chr9_107649565_107649816	0.38	Slc38a3	solute carrier family 38, member 3	6330	0.08
chr9_74866346_74866537	0.38	Onecut1	one cut domain, family member 1	43	0.97
chr13_41386761_41386912	0.37	Gm48571	predicted gene, 48571	6880	0.15
chr15_95039554_95039720	0.37	Gm23129	predicted gene, 23129	52499	0.17
chr6_108667181_108667428	0.37	Bhlhe40	basic helix-loop-helix family, member e40	4258	0.19
chr11_16589661_16589834	0.36	Gm12663	predicted gene 12663	46319	0.12
chr6_70874727_70874899	0.36	Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3	3748	0.18
chr11_65731180_65731331	0.36	Mir744	microRNA 744	3577	0.27
chr10_95354659_95354831	0.35	2310039L15Rik	RIKEN cDNA 2310039L15 gene	143	0.94
chr1_36228499_36228653	0.34	Uggt1	UDP-glucose glycoprotein glucosyltransferase 1	15531	0.16
chr19_12700970_12701121	0.34	Keg1	kidney expressed gene 1	5231	0.11
chr1_88040499_88040687	0.34	AC087801.1	UDP glycosyltransferase 1 family (Ytg1) pseudogene	2993	0.1
chr11_16850518_16850669	0.34	Egfros	epidermal growth factor receptor, opposite strand	19891	0.18
chr14_71251214_71251453	0.34	Gm4251	predicted gene 4251	49	0.99
chr2_72150298_72150627	0.33	Rapgef4os1	Rap guanine nucleotide exchange factor (GEF) 4, opposite strand 1	1666	0.39
chr7_97424078_97424348	0.32	Thrsp	thyroid hormone responsive	6483	0.13
chr11_94239763_94239948	0.32	Wfikkn2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	2852	0.23
chr7_140769076_140769314	0.32	Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	4714	0.1
chr8_114155044_114155305	0.32	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	21532	0.24
chr13_112283095_112283277	0.32	Ankrd55	ankyrin repeat domain 55	5265	0.19
chr12_32681759_32681933	0.32	Gm47937	predicted gene, 47937	8552	0.23
chr3_30802440_30802630	0.31	4933429H19Rik	RIKEN cDNA 4933429H19 gene	8971	0.14
chr18_20057458_20057675	0.31	Dsc2	desmocollin 2	1912	0.41
chr11_16780614_16780813	0.30	Egfr	epidermal growth factor receptor	28483	0.16
chr4_102646817_102646971	0.30	Pde4b	phosphodiesterase 4B, cAMP specific	57051	0.14
chr19_53781327_53781513	0.30	Rbm20	RNA binding motif protein 20	11888	0.17
chr14_18221191_18221360	0.30	Nr1d2	nuclear receptor subfamily 1, group D, member 2	8903	0.14
chr12_40218503_40218731	0.30	Ifrd1	interferon-related developmental regulator 1	1104	0.33
chr1_41557234_41557385	0.30	Gm28634	predicted gene 28634	27766	0.27
chr8_76540217_76540646	0.30	Gm27355	predicted gene, 27355	78851	0.1
chr6_149194053_149194312	0.30	Amn1	antagonist of mitotic exit network 1	5470	0.16
chrX_48054302_48054477	0.30	Apln	apelin	19536	0.2
chr5_102008790_102008983	0.29	Wdfy3	WD repeat and FYVE domain containing 3	27328	0.16
chr7_97414019_97414355	0.29	Thrsp	thyroid hormone responsive	3332	0.16
chr10_79350263_79350435	0.29	Vmn2r82	vomeronasal 2, receptor 82	6171	0.22
chr7_97569323_97569597	0.29	Aamdc	adipogenesis associated Mth938 domain containing	6193	0.13
chr3_69280240_69280391	0.29	Ppm1l	protein phosphatase 1 (formerly 2C)-like	36546	0.13
chr1_174842692_174842843	0.29	Grem2	gremlin 2, DAN family BMP antagonist	79052	0.11
chr8_77009522_77009673	0.29	Nr3c2	nuclear receptor subfamily 3, group C, member 2	101325	0.07
chr11_44520601_44520776	0.28	Rnf145	ring finger protein 145	383	0.85
chr15_67162617_67162836	0.28	St3gal1	ST3 beta-galactoside alpha-2,3-sialyltransferase 1	13986	0.25
chr7_70346773_70346973	0.28	Gm44948	predicted gene 44948	823	0.39
chr9_57679444_57679669	0.28	Cyp1a2	cytochrome P450, family 1, subfamily a, polypeptide 2	2480	0.18
chr16_81387153_81387317	0.28	Ncam2	neural cell adhesion molecule 2	78388	0.11
chr17_37190817_37190981	0.28	Ubd	ubiquitin D	2993	0.09
chr1_84758953_84759122	0.27	Trip12	thyroid hormone receptor interactor 12	1147	0.47
chr18_36656472_36656632	0.27	Ankhd1	ankyrin repeat and KH domain containing 1	1042	0.31
chr6_119362732_119362913	0.27	Adipor2	adiponectin receptor 2	25864	0.16
chr1_88044946_88045337	0.27	AC087801.1	UDP glycosyltransferase 1 family (Ytg1) pseudogene	7541	0.08
chr18_61675552_61675912	0.27	Il17b	interleukin 17B	9155	0.1
chr2_142804438_142804612	0.27	Gm22310	predicted gene, 22310	17629	0.25
chr11_118254084_118254269	0.27	Cyth1	cytohesin 1	5584	0.17
chr18_75498893_75499229	0.27	Gm10532	predicted gene 10532	15584	0.25
chr19_46741577_46741728	0.27	Cnnm2	cyclin M2	19944	0.14
chr15_58902616_58902767	0.27	Rnf139	ring finger protein 139	2554	0.18
chr2_118756278_118756444	0.26	Ccdc9b	coiled-coil domain containing 9B	6264	0.12
chr5_66114502_66114794	0.26	Rbm47	RNA binding motif protein 47	16457	0.11
chr14_30566208_30566359	0.26	Tkt	transketolase	1716	0.29
chr11_16892807_16893180	0.26	Egfr	epidermal growth factor receptor	12192	0.19
chrX_168899245_168899407	0.26	Arhgap6	Rho GTPase activating protein 6	104227	0.07
chr4_49566076_49566232	0.26	Aldob	aldolase B, fructose-bisphosphate	16608	0.13
chr14_57107820_57108112	0.26	Gjb2	gap junction protein, beta 2	3264	0.19
chr9_122849425_122849576	0.26	Gm47140	predicted gene, 47140	1082	0.34
chr6_128035036_128035224	0.26	Tspan9	tetraspanin 9	125	0.96
chr13_112271987_112272144	0.26	Ankrd55	ankyrin repeat domain 55	16386	0.16
chr1_34389167_34389350	0.26	Gm5266	predicted gene 5266	21887	0.09
chr8_125133982_125134146	0.25	Disc1	disrupted in schizophrenia 1	46077	0.14
chr14_63273010_63273187	0.25	Gata4	GATA binding protein 4	1406	0.4
chr15_77153006_77153219	0.25	Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	444	0.78
chr1_132362082_132362267	0.25	Tmcc2	transmembrane and coiled-coil domains 2	2774	0.18
chr13_44409176_44409378	0.25	Gm33958	predicted gene, 33958	18160	0.15
chr19_10097022_10097275	0.24	Fads2	fatty acid desaturase 2	4598	0.16
chr2_134827983_134828240	0.24	Gm14036	predicted gene 14036	24162	0.2
chr16_87610392_87610586	0.24	Gm22808	predicted gene, 22808	10631	0.19
chr11_84866770_84866933	0.24	Ggnbp2	gametogenetin binding protein 2	3351	0.15
chr7_144941851_144942303	0.24	Ccnd1	cyclin D1	2152	0.23
chr17_10745264_10745425	0.24	Gm16169	predicted gene 16169	62490	0.13
chr4_6261154_6261352	0.24	Gm11798	predicted gene 11798	288	0.91
chr5_65390468_65390702	0.24	Rpl9	ribosomal protein L9	248	0.79
chr5_120480072_120480223	0.24	Sds	serine dehydratase	216	0.8
chr13_111287126_111287324	0.24	Actbl2	actin, beta-like 2	32212	0.16
chr5_90314911_90315062	0.23	Ankrd17	ankyrin repeat domain 17	10882	0.21
chr12_108856815_108857551	0.23	Gm22079	predicted gene, 22079	5486	0.1
chr17_12168642_12168825	0.23	Agpat4	1-acylglycerol-3-phosphate O-acyltransferase 4 (lysophosphatidic acid acyltransferase, delta)	16961	0.18
chr9_122863893_122864050	0.23	Zfp445	zinc finger protein 445	1627	0.22
chr11_107337882_107338046	0.23	Gm11716	predicted gene 11716	86	0.79
chr8_125381516_125381735	0.23	Sipa1l2	signal-induced proliferation-associated 1 like 2	111085	0.06
chr4_53153864_53154038	0.23	Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	5944	0.24
chr19_12654451_12654602	0.23	Gm24521	predicted gene, 24521	10729	0.09
chr5_96979772_96979923	0.23	Gm9484	predicted gene 9484	17517	0.11
chr3_116955207_116955371	0.23	Gm42892	predicted gene 42892	10959	0.13
chr10_86350127_86350278	0.22	Timp3	tissue inhibitor of metalloproteinase 3	47348	0.13
chr11_110380321_110380711	0.22	Map2k6	mitogen-activated protein kinase kinase 6	18606	0.23
chr7_140768834_140769022	0.22	Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	4447	0.1
chr4_107999051_107999218	0.22	Slc1a7	solute carrier family 1 (glutamate transporter), member 7	10883	0.13
chr5_66559778_66559933	0.22	Apbb2	amyloid beta (A4) precursor protein-binding, family B, member 2	12898	0.15
chr9_122848440_122848788	0.22	Gm47140	predicted gene, 47140	196	0.89
chr2_52575707_52576080	0.22	Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	17326	0.18
chr1_9981778_9981956	0.22	Gm15818	predicted gene 15818	520	0.62
chr19_42678230_42678434	0.22	Gm25216	predicted gene, 25216	21570	0.17
chr6_93348262_93348414	0.22	Gm25094	predicted gene, 25094	12750	0.26
chr12_101875225_101875382	0.22	Trip11	thyroid hormone receptor interactor 11	8304	0.15
chr4_46139069_46139220	0.22	Tstd2	thiosulfate sulfurtransferase (rhodanese)-like domain containing 2	450	0.51
chr7_39524202_39524356	0.22	Zfp619	zinc finger protein 619	6513	0.13
chr5_54622556_54622707	0.22	Gm8069	predicted pseudogene 8069	29490	0.22
chr17_12895514_12895853	0.22	Pnldc1	poly(A)-specific ribonuclease (PARN)-like domain containing 1	99	0.91
chr8_9500530_9500773	0.22	4930435N07Rik	RIKEN cDNA 4930435N07 gene	41559	0.13
chr15_93825347_93825644	0.22	Gm49445	predicted gene, 49445	457	0.87
chr3_122890081_122890252	0.22	Fabp2	fatty acid binding protein 2, intestinal	4906	0.14
chr16_26678560_26678733	0.21	Il1rap	interleukin 1 receptor accessory protein	43788	0.18
chr8_61436826_61436991	0.21	Cbr4	carbonyl reductase 4	50826	0.12
chr2_68932763_68932937	0.21	Cers6	ceramide synthase 6	14410	0.14
chr1_10156105_10156276	0.21	Arfgef1	ADP-ribosylation factor guanine nucleotide-exchange factor 1(brefeldin A-inhibited)	1660	0.36
chr1_71807937_71808302	0.21	Gm37217	predicted gene, 37217	38491	0.15
chr15_91192098_91192262	0.21	Abcd2	ATP-binding cassette, sub-family D (ALD), member 2	381	0.87
chr11_51598115_51598266	0.21	Phykpl	5-phosphohydroxy-L-lysine phospholyase	1077	0.39
chr11_70057900_70058083	0.21	Asgr1	asialoglycoprotein receptor 1	2110	0.15
chr5_63953741_63953922	0.21	Rell1	RELT-like 1	14992	0.15
chr13_31401311_31401475	0.21	G630018N14Rik	RIKEN cDNA G630018N14 gene	7529	0.16
chr7_19560953_19561121	0.21	Ppp1r37	protein phosphatase 1, regulatory subunit 37	2039	0.16
chr14_120313311_120313499	0.21	Mbnl2	muscleblind like splicing factor 2	6949	0.28
chr1_73630126_73630279	0.21	C530043A13Rik	RIKEN cDNA C530043A13 gene	100412	0.06
chr19_26765890_26766041	0.21	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	4526	0.25
chr13_74506069_74506220	0.21	Gm49763	predicted gene, 49763	12001	0.1
chr4_102576883_102577034	0.21	Pde4b	phosphodiesterase 4B, cAMP specific	6863	0.31
chr1_174900896_174901097	0.21	Grem2	gremlin 2, DAN family BMP antagonist	20823	0.27
chr9_57686463_57686734	0.21	Cyp1a1	cytochrome P450, family 1, subfamily a, polypeptide 1	1330	0.3
chr7_67609230_67609410	0.20	Lrrc28	leucine rich repeat containing 28	2058	0.25
chr5_28374728_28374917	0.20	Rbm33	RNA binding motif protein 33	19233	0.22
chr12_104081605_104081762	0.20	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	1034	0.36
chr2_134524166_134524489	0.20	Hao1	hydroxyacid oxidase 1, liver	29980	0.24
chr1_54496220_54496429	0.20	Gm36955	predicted gene, 36955	23946	0.15
chr6_67385240_67385404	0.20	Gm8574	predicted gene 8574	19	0.97
chr5_64075656_64075807	0.20	Pgm2	phosphoglucomutase 2	17219	0.12
chr2_31745875_31746037	0.20	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	13987	0.14
chr15_59061763_59061914	0.20	Mtss1	MTSS I-BAR domain containing 1	6374	0.24
chr8_66587441_66587788	0.20	Gm16330	predicted gene 16330	1394	0.48
chr19_60532004_60532219	0.20	Cacul1	CDK2 associated, cullin domain 1	5438	0.23
chr15_35876710_35876861	0.20	Vps13b	vacuolar protein sorting 13B	5063	0.18
chr11_16837434_16837735	0.20	Egfros	epidermal growth factor receptor, opposite strand	6882	0.22
chr4_117125610_117126073	0.20	Btbd19	BTB (POZ) domain containing 19	116	0.86
chr6_48684930_48685081	0.20	Gimap4	GTPase, IMAP family member 4	423	0.63
chr14_87140699_87141139	0.20	Diaph3	diaphanous related formin 3	224	0.95
chr13_34898393_34898709	0.20	Prpf4b	pre-mRNA processing factor 4B	3098	0.15
chr4_73048259_73048424	0.20	Gm11251	predicted gene 11251	18522	0.24
chr12_83905337_83905488	0.20	Numb	NUMB endocytic adaptor protein	16321	0.11
chr12_57650772_57650931	0.20	Ttc6	tetratricopeptide repeat domain 6	1436	0.35
chr7_34226333_34226490	0.20	Gpi1	glucose-6-phosphate isomerase 1	2586	0.14
chr2_27769095_27769412	0.20	Rxra	retinoid X receptor alpha	29052	0.21
chr4_3408345_3408692	0.20	Gm11784	predicted gene 11784	21672	0.18
chr16_9588741_9588894	0.19	Grin2a	glutamate receptor, ionotropic, NMDA2A (epsilon 1)	208516	0.02
chr8_76151909_76152060	0.19	Gm45742	predicted gene 45742	34957	0.2
chr18_12948248_12948402	0.19	Osbpl1a	oxysterol binding protein-like 1A	6484	0.18
chr5_148978578_148978772	0.19	Gm42791	predicted gene 42791	2418	0.14
chr4_102566844_102566995	0.19	Pde4b	phosphodiesterase 4B, cAMP specific	3176	0.38
chr2_167292312_167292496	0.19	Gm11473	predicted gene 11473	10627	0.16
chr5_77406298_77406449	0.19	Igfbp7	insulin-like growth factor binding protein 7	1667	0.3
chr11_16799047_16799198	0.19	Egfros	epidermal growth factor receptor, opposite strand	31580	0.16
chr15_25942411_25942580	0.19	Retreg1	reticulophagy regulator 1	184	0.95
chr9_107298322_107298733	0.19	Cish	cytokine inducible SH2-containing protein	628	0.48
chr13_62867105_62867323	0.19	Fbp1	fructose bisphosphatase 1	5544	0.14
chr2_132677140_132677304	0.19	Gm14098	predicted gene 14098	1047	0.36

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Crx_Gsc

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.4	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.5	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.3	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.1	0.2	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.4	GO:0006526	arginine biosynthetic process(GO:0006526)
0.1	0.2	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.1	0.2	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	0.6	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.1	0.2	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.1	0.1	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.1	0.2	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.4	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.0	0.3	GO:0042866	pyruvate biosynthetic process(GO:0042866)
0.0	0.2	GO:0048861	leukemia inhibitory factor signaling pathway(GO:0048861)
0.0	0.2	GO:0000957	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.1	GO:0051594	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.2	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.2	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.1	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.2	GO:0060283	negative regulation of oocyte development(GO:0060283)
0.0	0.2	GO:0042760	very long-chain fatty acid catabolic process(GO:0042760)
0.0	0.1	GO:0061010	gall bladder development(GO:0061010)
0.0	0.1	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.1	GO:1902915	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.1	GO:0060331	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.1	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.1	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:2000019	negative regulation of male gonad development(GO:2000019)
0.0	0.1	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.1	GO:0090427	activation of meiosis(GO:0090427)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.2	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.1	GO:0035907	dorsal aorta development(GO:0035907) dorsal aorta morphogenesis(GO:0035912)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.2	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.1	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.2	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.0	GO:1903750	regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0	0.0	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.0	0.3	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.1	GO:0031443	fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.0	0.1	GO:2000598	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.0	0.1	GO:1902894	negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.0	0.2	GO:0033625	positive regulation of integrin activation(GO:0033625)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.0	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.1	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.1	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.1	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.1	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	0.1	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.1	GO:1903142	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0	0.1	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0048014	Tie signaling pathway(GO:0048014)
0.0	0.1	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.1	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.0	0.0	GO:0001834	trophectodermal cell proliferation(GO:0001834)
0.0	0.2	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.0	0.0	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.1	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0060468	prevention of polyspermy(GO:0060468)
0.0	0.6	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.0	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.0	0.1	GO:1900238	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0	0.0	GO:1905216	positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0	0.1	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.1	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.4	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0009794	regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.1	GO:0023021	termination of signal transduction(GO:0023021)
0.0	0.0	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.0	0.1	GO:0043987	histone H3-S10 phosphorylation(GO:0043987)
0.0	0.1	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.1	GO:0090283	regulation of protein glycosylation in Golgi(GO:0090283)
0.0	0.0	GO:0055099	response to high density lipoprotein particle(GO:0055099)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.1	GO:0051466	positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0	0.0	GO:1904833	positive regulation of superoxide dismutase activity(GO:1901671) positive regulation of removal of superoxide radicals(GO:1904833)
0.0	0.1	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.1	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0046292	formaldehyde metabolic process(GO:0046292)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.2	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0006559	L-phenylalanine metabolic process(GO:0006558) L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0021780	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0060178	regulation of exocyst localization(GO:0060178)
0.0	0.0	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.1	GO:0030647	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0060112	generation of ovulation cycle rhythm(GO:0060112)
0.0	0.0	GO:1901856	negative regulation of cellular respiration(GO:1901856)
0.0	0.1	GO:0010994	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0	0.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.0	GO:0032077	positive regulation of deoxyribonuclease activity(GO:0032077)
0.0	0.0	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.2	GO:0060546	negative regulation of necroptotic process(GO:0060546)
0.0	0.0	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.0	0.1	GO:0034227	tRNA thio-modification(GO:0034227)
0.0	0.1	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0	0.0	GO:0048295	positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0	0.1	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.1	GO:0046130	purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0	0.1	GO:0051295	establishment of meiotic spindle localization(GO:0051295)
0.0	0.1	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.0	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.0	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.1	GO:0071397	cellular response to cholesterol(GO:0071397)
0.0	0.1	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.0	GO:0043307	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil activation(GO:0043307) eosinophil degranulation(GO:0043308)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.1	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.0	0.0	GO:1902996	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.1	GO:0032354	response to follicle-stimulating hormone(GO:0032354)
0.0	0.1	GO:1905049	negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
0.0	0.0	GO:0032788	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.1	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.0	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0030035	microspike assembly(GO:0030035)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0070141	response to UV-A(GO:0070141)
0.0	0.0	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.0	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
0.0	0.1	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.0	GO:0046391	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0	0.1	GO:0045842	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.0	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.0	GO:0006083	acetate metabolic process(GO:0006083)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.0	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.0	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.0	GO:0007343	egg activation(GO:0007343)
0.0	0.0	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0	0.1	GO:0097369	sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0	0.0	GO:0010481	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0034398	telomere tethering at nuclear periphery(GO:0034398)
0.0	0.0	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.0	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
0.0	0.0	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.1	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.0	GO:1903416	response to glycoside(GO:1903416)
0.0	0.0	GO:2000097	regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0	0.4	GO:0048536	spleen development(GO:0048536)
0.0	0.0	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.0	0.0	GO:0098739	import across plasma membrane(GO:0098739)
0.0	0.1	GO:0030836	positive regulation of actin filament depolymerization(GO:0030836)
0.0	0.0	GO:1900044	regulation of protein K63-linked ubiquitination(GO:1900044)
0.0	0.0	GO:0034627	'de novo' NAD biosynthetic process(GO:0034627)
0.0	0.0	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.1	GO:0060252	positive regulation of glial cell proliferation(GO:0060252)
0.0	0.1	GO:0071380	cellular response to prostaglandin E stimulus(GO:0071380)
0.0	0.1	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.0	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:1901536	regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.0	0.2	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.0	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.0	GO:0001555	oocyte growth(GO:0001555)
0.0	0.1	GO:0007199	G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
0.0	0.2	GO:0006883	cellular sodium ion homeostasis(GO:0006883)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.4	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.2	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.2	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.2	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.3	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.2	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.1	GO:0044611	nuclear pore inner ring(GO:0044611)
0.0	0.1	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0030689	Noc complex(GO:0030689)
0.0	0.2	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	0.1	GO:0034518	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0002079	inner acrosomal membrane(GO:0002079)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.2	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.0	0.0	GO:0005955	calcineurin complex(GO:0005955)
0.0	0.1	GO:0000243	commitment complex(GO:0000243)
0.0	0.1	GO:0032039	integrator complex(GO:0032039)
0.0	0.2	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.4	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	0.2	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.2	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.1	0.2	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.2	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.3	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0015186	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.2	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.0	0.2	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.2	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.1	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.0	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	0.2	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.2	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0	0.1	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.1	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.2	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0010858	calcium-dependent protein kinase regulator activity(GO:0010858)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.5	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0	0.1	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.3	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.5	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.0	0.4	GO:0005149	interleukin-1 receptor binding(GO:0005149)
0.0	0.2	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.0	GO:0030519	snoRNP binding(GO:0030519)
0.0	0.1	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.4	GO:0016655	oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.0	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.2	GO:0008307	structural constituent of muscle(GO:0008307)
0.0	0.0	GO:0019166	trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0	0.0	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.0	GO:0089720	caspase binding(GO:0089720)
0.0	0.1	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.1	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.1	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.0	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0016783	sulfurtransferase activity(GO:0016783)
0.0	0.0	GO:0034617	tetrahydrobiopterin binding(GO:0034617)
0.0	0.0	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.0	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.0	GO:0061665	SUMO ligase activity(GO:0061665)
0.0	0.0	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
0.0	0.1	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.0	GO:0034040	lipid-transporting ATPase activity(GO:0034040)
0.0	0.0	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0042015	interleukin-20 binding(GO:0042015)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.0	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.0	GO:0000293	ferric-chelate reductase activity(GO:0000293)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.0	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0	0.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.2	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.3	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.0	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.0	0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.4	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.4	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.4	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.1	0.3	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.3	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.8	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.3	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.2	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.0	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.0	0.0	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.4	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.1	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.2	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.1	REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the late endosome membrane
0.0	0.1	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins