Project

ENCSR904DTN: DNase-seq of mouse liver in constant darkness

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for E2f8

Z-value: 0.76

Motif logo

Transcription factors associated with E2f8

Gene Symbol	Gene ID	Gene Info
E2f8 Ensembl NCBI MGI UniProt	ENSMUSG00000046179.11	E2f8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
E2f8	chr7_48881843_48881994	322	0.671583	0.71	1.1e-01	Click!
E2f8	chr7_48881042_48881203	81	0.634327	-0.70	1.2e-01	Click!
E2f8	chr7_48876389_48876556	1221	0.312305	0.67	1.5e-01	Click!
E2f8	chr7_48874212_48874416	937	0.459593	0.62	1.9e-01	Click!
E2f8	chr7_48873974_48874135	1197	0.368804	-0.44	3.8e-01	Click!

Activity of the E2f8 motif across conditions

Conditions sorted by the z-value of the E2f8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_9825489_9825685	1.34	Gdf6	growth differentiation factor 6	18785	0.21
chr6_149144321_149144479	1.13	Etfbkmt	electron transfer flavoprotein beta subunit lysine methyltransferase	2754	0.18
chr4_137795816_137796289	0.96	Alpl	alkaline phosphatase, liver/bone/kidney	178	0.96
chr7_121981237_121981388	0.91	Cog7	component of oligomeric golgi complex 7	382	0.51
chr2_160715771_160715932	0.65	Top1	topoisomerase (DNA) I	1618	0.36
chr2_134544863_134545049	0.52	Hao1	hydroxyacid oxidase 1, liver	9351	0.3
chr11_16817302_16817617	0.46	Egfros	epidermal growth factor receptor, opposite strand	13243	0.21
chr15_98092785_98093187	0.44	Senp1	SUMO1/sentrin specific peptidase 1	99	0.64
chr2_134795038_134795224	0.43	Plcb1	phospholipase C, beta 1	8601	0.19
chr10_95415293_95415489	0.43	Socs2	suppressor of cytokine signaling 2	93	0.95
chrX_140538959_140539298	0.42	Tsc22d3	TSC22 domain family, member 3	3540	0.25
chr5_53277740_53277949	0.37	Smim20	small integral membrane protein 20	726	0.65
chr4_3835532_3835858	0.37	Rps20	ribosomal protein S20	30	0.9
chr1_100410526_100410677	0.35	Gm29667	predicted gene 29667	127810	0.05
chr6_117360618_117360785	0.34	Gm4640	predicted gene 4640	62916	0.12
chr16_34047934_34048195	0.34	Kalrn	kalirin, RhoGEF kinase	31570	0.17
chr6_136906748_136907166	0.33	Erp27	endoplasmic reticulum protein 27	15183	0.11
chr2_43522117_43522300	0.33	Gm13464	predicted gene 13464	2810	0.36
chr9_36726566_36726754	0.32	Chek1	checkpoint kinase 1	2	0.96
chr11_78115153_78115348	0.32	Fam222b	family with sequence similarity 222, member B	356	0.73
chr5_22587487_22587999	0.31	Gm9057	predicted gene 9057	23786	0.11
chr4_84545854_84546088	0.31	Bnc2	basonuclin 2	319	0.94
chr11_117810052_117810409	0.31	Syngr2	synaptogyrin 2	518	0.39
chr8_35582440_35582591	0.30	Mfhas1	malignant fibrous histiocytoma amplified sequence 1	5283	0.21
chr13_101719143_101719316	0.30	Pik3r1	phosphoinositide-3-kinase regulatory subunit 1	17125	0.2
chr3_121801857_121802086	0.30	Abcd3	ATP-binding cassette, sub-family D (ALD), member 3	12938	0.12
chr10_87030293_87030475	0.29	Stab2	stabilin 2	22359	0.14
chr5_124172698_124172925	0.29	Pitpnm2	phosphatidylinositol transfer protein, membrane-associated 2	12307	0.12
chr6_54046378_54046711	0.28	Chn2	chimerin 2	6458	0.22
chr11_29172228_29172645	0.28	Ppp4r3b	protein phosphatase 4 regulatory subunit 3B	454	0.71
chr10_68147784_68148076	0.28	Arid5b	AT rich interactive domain 5B (MRF1-like)	11304	0.26
chr15_59072163_59072449	0.27	Mtss1	MTSS I-BAR domain containing 1	9683	0.23
chr15_55090636_55090987	0.27	Dscc1	DNA replication and sister chromatid cohesion 1	320	0.85
chr2_25195851_25196175	0.27	Tor4a	torsin family 4, member A	746	0.34
chr2_18048778_18049088	0.27	Skida1	SKI/DACH domain containing 1	98	0.94
chr1_175634536_175634795	0.27	Kmo	kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)	2426	0.25
chr12_12941753_12942056	0.25	Mycn	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	10	0.97
chr3_34020715_34021194	0.24	Fxr1	fragile X mental retardation gene 1, autosomal homolog	846	0.39
chr9_94016628_94017010	0.23	Gm5369	predicted gene 5369	122643	0.06
chr8_121953313_121953464	0.23	Gm27011	predicted gene, 27011	2743	0.14
chr9_64281144_64281332	0.22	Tipin	timeless interacting protein	343	0.81
chrX_60825498_60825671	0.22	Gm14660	predicted gene 14660	7376	0.21
chr8_112010835_112011224	0.21	Kars	lysyl-tRNA synthetase	237	0.62
chr15_82266462_82266636	0.21	Septin3	septin 3	2253	0.14
chr11_90389300_90389483	0.21	Hlf	hepatic leukemia factor	199	0.96
chr15_57693839_57694019	0.20	Zhx2	zinc fingers and homeoboxes 2	736	0.69
chr2_44113422_44113573	0.20	Arhgap15os	Rho GTPase activating protein 15, opposite strand	48173	0.17
chr11_80081649_80082056	0.20	Crlf3	cytokine receptor-like factor 3	861	0.55
chr14_34188761_34188924	0.20	Gm18884	predicted gene, 18884	12533	0.08
chr9_96823694_96824186	0.19	Gm8520	predicted gene 8520	9606	0.15
chr17_35236084_35236374	0.18	Atp6v1g2	ATPase, H+ transporting, lysosomal V1 subunit G2	333	0.45
chr15_99045316_99045476	0.18	Prph	peripherin	9778	0.09
chr16_78481019_78481170	0.18	Gm49603	predicted gene, 49603	555	0.75
chr4_46649810_46649996	0.18	Tbc1d2	TBC1 domain family, member 2	306	0.9
chr18_16608064_16608271	0.18	Cdh2	cadherin 2	61902	0.14
chr11_98979666_98979817	0.18	Gjd3	gap junction protein, delta 3	3275	0.14
chr11_95307677_95307905	0.18	Kat7	K(lysine) acetyltransferase 7	1722	0.24
chr19_28998112_28998308	0.18	Cdc37l1	cell division cycle 37-like 1	1107	0.35
chr13_93996913_93997222	0.18	Gm47216	predicted gene, 47216	5299	0.2
chr4_117131265_117131506	0.18	Plk3	polo like kinase 3	2414	0.1
chr5_23787902_23788378	0.17	Rint1	RAD50 interactor 1	399	0.71
chr10_47582131_47582287	0.17	Gm47571	predicted gene, 47571	57914	0.17
chr3_136428039_136428202	0.16	1700030L20Rik	RIKEN cDNA 1700030L20 gene	21229	0.23
chr15_78845338_78845568	0.16	Cdc42ep1	CDC42 effector protein (Rho GTPase binding) 1	2829	0.13
chr4_145229848_145230015	0.16	Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	16939	0.19
chr13_112196528_112196688	0.16	Gm37427	predicted gene, 37427	22585	0.16
chr2_84744034_84744230	0.16	Gm19426	predicted gene, 19426	477	0.61
chr11_26386927_26387278	0.15	Fancl	Fanconi anemia, complementation group L	100	0.97
chr1_67099324_67099498	0.15	Cps1	carbamoyl-phosphate synthetase 1	23615	0.2
chrX_150594237_150594425	0.15	Pfkfb1	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1	147	0.94
chr16_70354766_70354917	0.15	Gbe1	glucan (1,4-alpha-), branching enzyme 1	40707	0.19
chr11_79992533_79993138	0.15	Suz12	SUZ12 polycomb repressive complex 2 subunit	271	0.91
chr3_51229561_51229725	0.15	Gm38357	predicted gene, 38357	2274	0.22
chr4_120825407_120825586	0.15	Nfyc	nuclear transcription factor-Y gamma	188	0.91
chr19_40158669_40158820	0.15	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	28542	0.13
chr1_192812225_192812480	0.15	Gm38360	predicted gene, 38360	8775	0.14
chr15_75205125_75205276	0.15	Gm28117	predicted gene 28117	7533	0.12
chr14_47242891_47243067	0.14	Wdhd1	WD repeat and HMG-box DNA binding protein 1	2291	0.15
chr16_34824937_34825201	0.14	Mylk	myosin, light polypeptide kinase	40148	0.18
chr19_6305879_6306268	0.14	Cdc42bpg	CDC42 binding protein kinase gamma (DMPK-like)	383	0.68
chr7_102065637_102065828	0.14	Xntrpc	Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough	19	0.44
chr2_165070502_165070653	0.14	Cd40	CD40 antigen	7901	0.15
chr16_38293144_38293465	0.14	Nr1i2	nuclear receptor subfamily 1, group I, member 2	1520	0.32
chr10_10836079_10836268	0.13	4930567K20Rik	RIKEN cDNA 4930567K20 gene	85093	0.08
chr4_43010254_43010416	0.13	Fancg	Fanconi anemia, complementation group G	20	0.95
chr2_33370578_33371002	0.13	Ralgps1	Ral GEF with PH domain and SH3 binding motif 1	639	0.68
chr11_55204467_55204772	0.13	Slc36a1	solute carrier family 36 (proton/amino acid symporter), member 1	243	0.9
chr13_51073365_51073844	0.13	Spin1	spindlin 1	27276	0.21
chr9_102721358_102721856	0.13	Amotl2	angiomotin-like 2	709	0.56
chr10_43312960_43313230	0.12	Gm16546	predicted gene 16546	6265	0.19
chrX_77810630_77810940	0.12	Gm14742	predicted gene 14742	7505	0.16
chr6_145865754_145865981	0.12	Bhlhe41	basic helix-loop-helix family, member e41	309	0.87
chr8_105881480_105881631	0.12	Edc4	enhancer of mRNA decapping 4	478	0.59
chr8_128446539_128446690	0.12	Nrp1	neuropilin 1	87217	0.09
chr4_108064276_108064464	0.11	Scp2	sterol carrier protein 2, liver	6993	0.14
chr18_53859942_53860093	0.11	Csnk1g3	casein kinase 1, gamma 3	2105	0.44
chr11_31888267_31888568	0.11	Cpeb4	cytoplasmic polyadenylation element binding protein 4	15142	0.2
chr10_19552959_19553256	0.11	Gm48563	predicted gene, 48563	30457	0.15
chr1_51879717_51879868	0.11	Gm28323	predicted gene 28323	184	0.93
chr17_64205783_64206178	0.11	Pja2	praja ring finger ubiquitin ligase 2	107051	0.07
chr1_161260611_161260770	0.11	Prdx6	peroxiredoxin 6	9471	0.17
chr2_150778031_150778205	0.11	Pygb	brain glycogen phosphorylase	8617	0.15
chr17_15423433_15423758	0.11	Gm49668	predicted gene, 49668	11369	0.13
chr9_103349628_103349779	0.11	Topbp1	topoisomerase (DNA) II binding protein 1	3475	0.19
chr13_21783769_21783949	0.11	H3c11	H3 clustered histone 11	489	0.44
chr1_69108079_69108251	0.10	Erbb4	erb-b2 receptor tyrosine kinase 4	106	0.96
chr13_89551647_89551801	0.10	Hapln1	hyaluronan and proteoglycan link protein 1	11928	0.23
chr5_20589642_20589807	0.10	Gm3544	predicted gene 3544	1128	0.56
chr4_150740556_150740736	0.10	Gm16079	predicted gene 16079	61854	0.1
chr16_17125381_17125599	0.10	2610318N02Rik	RIKEN cDNA 2610318N02 gene	323	0.64
chr3_18624191_18624481	0.10	Gm42944	predicted gene 42944	2174	0.32
chr16_10834941_10835111	0.10	Rmi2	RecQ mediated genome instability 2	33	0.95
chr4_125451423_125451580	0.10	Grik3	glutamate receptor, ionotropic, kainate 3	39199	0.16
chr2_51143066_51143386	0.10	Rnd3	Rho family GTPase 3	5868	0.27
chr1_71649974_71650188	0.09	Apol7d	apolipoprotein L 7d	2756	0.24
chr8_23436686_23436866	0.09	Sfrp1	secreted frizzled-related protein 1	25274	0.22
chr18_12861326_12861482	0.09	Osbpl1a	oxysterol binding protein-like 1A	199	0.89
chr11_16820788_16820939	0.09	Egfros	epidermal growth factor receptor, opposite strand	9839	0.22
chr3_96700485_96700645	0.09	Pias3	protein inhibitor of activated STAT 3	87	0.92
chr14_99100245_99100396	0.09	Pibf1	progesterone immunomodulatory binding factor 1	362	0.61
chr5_125173585_125173942	0.09	Ncor2	nuclear receptor co-repressor 2	5290	0.24
chr6_83421822_83421997	0.09	5430434F05Rik	RIKEN cDNA 5430434F05 gene	917	0.44
chrX_159255089_159255806	0.09	Rps6ka3	ribosomal protein S6 kinase polypeptide 3	335	0.92
chr13_12457926_12458454	0.09	Lgals8	lectin, galactose binding, soluble 8	1667	0.31
chr1_131276568_131276872	0.09	Ikbke	inhibitor of kappaB kinase epsilon	7	0.96
chr17_32205448_32205665	0.09	Brd4	bromodomain containing 4	4548	0.14
chr7_64497544_64497716	0.09	Apba2	amyloid beta (A4) precursor protein-binding, family A, member 2	4076	0.21
chr17_71598268_71598610	0.08	Trmt61b	tRNA methyltransferase 61B	186	0.89
chr13_24316648_24316847	0.08	Gm23340	predicted gene, 23340	105	0.94
chr16_16146290_16146715	0.08	Spidr	scaffolding protein involved in DNA repair	302	0.91
chr10_17531063_17531258	0.08	Gm47770	predicted gene, 47770	4246	0.22
chr6_116092433_116092702	0.08	Gm20404	predicted gene 20404	15083	0.15
chr14_70351659_70351817	0.08	Slc39a14	solute carrier family 39 (zinc transporter), member 14	313	0.84
chr17_25792594_25792983	0.08	Fam173a	family with sequence similarity 173, member A	10	0.9
chr5_140783617_140783781	0.08	Amz1	archaelysin family metallopeptidase 1	34416	0.14
chr3_95218073_95218246	0.08	Gabpb2	GA repeat binding protein, beta 2	243	0.72
chr1_151178576_151178751	0.07	Gm47985	predicted gene, 47985	3874	0.14
chr15_57912367_57912734	0.07	Tbc1d31	TBC1 domain family, member 31	311	0.9
chr6_113624952_113625185	0.07	Vhl	von Hippel-Lindau tumor suppressor	139	0.89
chr1_179108579_179108982	0.07	Smyd3	SET and MYND domain containing 3	119435	0.06
chr6_15721066_15721382	0.07	Mdfic	MyoD family inhibitor domain containing	137	0.98
chr18_32556472_32556888	0.07	Gypc	glycophorin C	3300	0.27
chr16_33381984_33382411	0.07	Zfp148	zinc finger protein 148	579	0.7
chr1_45795644_45795998	0.07	Wdr75	WD repeat domain 75	314	0.86
chrX_85112549_85112727	0.07	Dmd	dystrophin, muscular dystrophy	64225	0.13
chr12_111114376_111114527	0.07	Gm48632	predicted gene, 48632	23251	0.13
chr9_57064508_57064675	0.07	Ptpn9	protein tyrosine phosphatase, non-receptor type 9	5153	0.14
chrX_113185187_113185419	0.07	Chm	choroidermia (RAB escort protein 1)	206	0.95
chr6_115717866_115718504	0.06	Gm24008	predicted gene, 24008	5647	0.12
chr6_54051509_54051688	0.06	Chn2	chimerin 2	11512	0.21
chr11_54860913_54861249	0.06	Lyrm7	LYR motif containing 7	165	0.93
chr4_43000782_43000941	0.06	Vcp	valosin containing protein	354	0.76
chr1_140267167_140267318	0.06	Gm37777	predicted gene, 37777	755	0.71
chr16_7100033_7100384	0.06	Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	30362	0.27
chr6_37440535_37440868	0.06	Creb3l2	cAMP responsive element binding protein 3-like 2	1445	0.53
chr19_55895196_55895361	0.06	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	232	0.95
chr13_30338451_30338663	0.06	Agtr1a	angiotensin II receptor, type 1a	2113	0.34
chr16_17619254_17619416	0.06	Smpd4	sphingomyelin phosphodiesterase 4	19	0.96
chr3_88497845_88497996	0.06	Lmna	lamin A	4608	0.09
chr2_130905756_130906591	0.06	A730017L22Rik	RIKEN cDNA A730017L22 gene	183	0.45
chr17_32272780_32272931	0.06	Brd4	bromodomain containing 4	490	0.72
chr16_92465382_92465533	0.06	Rcan1	regulator of calcineurin 1	686	0.61
chr11_102318700_102318851	0.06	Ubtf	upstream binding transcription factor, RNA polymerase I	321	0.8
chr2_17423032_17423195	0.05	Nebl	nebulette	32105	0.23
chr11_79253815_79253989	0.05	Wsb1	WD repeat and SOCS box-containing 1	568	0.72
chr5_132546141_132546320	0.05	Gm42626	predicted gene 42626	174	0.91
chr8_94358704_94358868	0.05	Slc12a3	solute carrier family 12, member 3	2475	0.16
chrX_19166759_19167084	0.05	Gm14636	predicted gene 14636	311	0.9
chr9_22003120_22003482	0.05	Prkcsh	protein kinase C substrate 80K-H	84	0.88
chr5_149007925_149008200	0.05	Gm15408	predicted gene 15408	1100	0.3
chr15_80977693_80977853	0.05	Sgsm3	small G protein signaling modulator 3	6	0.96
chr9_32541639_32541830	0.05	Fli1	Friend leukemia integration 1	139	0.93
chr4_95737745_95737908	0.05	Fggy	FGGY carbohydrate kinase domain containing	582	0.84
chr18_74794198_74794360	0.05	Acaa2	acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)	896	0.53
chr8_109737758_109738093	0.05	Atxn1l	ataxin 1-like	186	0.93
chr12_59060973_59061324	0.05	Trappc6b	trafficking protein particle complex 6B	196	0.9
chr4_137942824_137943002	0.04	Ece1	endothelin converting enzyme 1	29231	0.17
chr10_122679401_122679658	0.04	Mir8104	microRNA 8104	214	0.84
chr15_55557483_55557916	0.04	Mtbp	Mdm2, transformed 3T3 cell double minute p53 binding protein	36	0.51
chr2_122070032_122070198	0.04	Eif3j1	eukaryotic translation initiation factor 3, subunit J1	41463	0.1
chr11_16796275_16796460	0.04	Egfros	epidermal growth factor receptor, opposite strand	34335	0.15
chr1_128102401_128102560	0.04	Zranb3	zinc finger, RAN-binding domain containing 3	17	0.91
chr1_128359683_128359850	0.04	Mcm6	minichromosome maintenance complex component 6	102	0.96
chr16_22263821_22263972	0.04	Tra2b	transformer 2 beta	2004	0.22
chr19_37561242_37561423	0.04	Exoc6	exocyst complex component 6	10873	0.21
chr19_46503050_46503201	0.04	Trim8	tripartite motif-containing 8	1423	0.35
chr15_81522098_81522372	0.04	Gm5218	predicted gene 5218	22690	0.11
chr6_122872904_122873082	0.04	Necap1	NECAP endocytosis associated 1	1481	0.27
chr8_109991339_109991991	0.04	Tat	tyrosine aminotransferase	1159	0.36
chr11_79712044_79712202	0.04	Mir193a	microRNA 193a	154	0.93
chr12_80949222_80949570	0.04	Srsf5	serine and arginine-rich splicing factor 5	3020	0.17
chr13_101349484_101349644	0.04	Gm2534	predicted gene 2534	812	0.69
chr2_90545522_90545673	0.04	Ptprj	protein tyrosine phosphatase, receptor type, J	35050	0.16
chr8_46376394_46376573	0.04	Gm45253	predicted gene 45253	9405	0.14
chr17_4907841_4908226	0.03	4930579D07Rik	RIKEN cDNA 4930579D07 gene	15046	0.19
chr1_71102457_71102615	0.03	Bard1	BRCA1 associated RING domain 1	610	0.8
chr16_24151105_24151294	0.03	Gm32126	predicted gene, 32126	17362	0.19
chr2_105932157_105932324	0.03	Immp1l	IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)	27602	0.13
chr2_30042566_30042728	0.03	Wdr34	WD repeat domain 34	6214	0.11
chr13_9494911_9495081	0.03	Gm48871	predicted gene, 48871	49096	0.12

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0034421	post-translational protein acetylation(GO:0034421)
0.1	0.3	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.1	0.2	GO:0048478	replication fork protection(GO:0048478)
0.1	0.3	GO:0006975	DNA damage induced protein phosphorylation(GO:0006975)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.5	GO:0060396	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.2	GO:0006265	DNA topological change(GO:0006265)
0.0	0.9	GO:0036075	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.2	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0033133	positive regulation of glucokinase activity(GO:0033133)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.1	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.2	GO:0045631	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:0048239	negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0	0.1	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.5	GO:0034067	protein localization to Golgi apparatus(GO:0034067)
0.0	0.1	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:0042525	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0	0.3	GO:1900745	positive regulation of p38MAPK cascade(GO:1900745)
0.0	0.1	GO:2000152	regulation of ubiquitin-specific protease activity(GO:2000152)
0.0	0.1	GO:0061622	glycolytic process through glucose-1-phosphate(GO:0061622)
0.0	0.3	GO:0003416	endochondral bone growth(GO:0003416)
0.0	0.1	GO:0072757	cellular response to camptothecin(GO:0072757)
0.0	0.0	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0033234	negative regulation of protein sumoylation(GO:0033234)
0.0	0.0	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:2000637	positive regulation of gene silencing by miRNA(GO:2000637)
0.0	0.0	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0060628	regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0	0.1	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0018344	protein geranylgeranylation(GO:0018344)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)
0.0	0.2	GO:0031298	replication fork protection complex(GO:0031298)
0.0	0.5	GO:0017119	Golgi transport complex(GO:0017119)
0.0	0.1	GO:0070939	Dsl1p complex(GO:0070939)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.2	GO:0031390	Ctf18 RFC-like complex(GO:0031390)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.3	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0005945	6-phosphofructokinase complex(GO:0005945)
0.0	0.1	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0030870	Mre11 complex(GO:0030870)
0.0	0.1	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.9	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.1	0.3	GO:0070137	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1	0.4	GO:0005131	growth hormone receptor binding(GO:0005131)
0.1	0.3	GO:0035184	histone threonine kinase activity(GO:0035184)
0.1	0.2	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.2	GO:0070095	fructose-6-phosphate binding(GO:0070095)
0.0	0.2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.2	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0036435	K48-linked polyubiquitin binding(GO:0036435)
0.0	0.1	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.2	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.1	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0038132	neuregulin binding(GO:0038132)
0.0	0.1	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.3	PID BARD1 PATHWAY	BARD1 signaling events
0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.4	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.3	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.2	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling