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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for E2f8

Z-value: 0.76

Motif logo

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Transcription factors associated with E2f8

Gene Symbol Gene ID Gene Info
E2f8
ENSMUSG00000046179.11 E2F transcription factor 8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr7_48881843_48881994E2f83220.6715830.711.1e-01Click!
chr7_48881042_48881203E2f8810.634327-0.701.2e-01Click!
chr7_48876389_48876556E2f812210.3123050.671.5e-01Click!
chr7_48874212_48874416E2f89370.4595930.621.9e-01Click!
chr7_48873974_48874135E2f811970.368804-0.443.8e-01Click!

Activity of the E2f8 motif across conditions

Conditions sorted by the z-value of the E2f8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr4_9825489_9825685 1.34 Gdf6
 growth differentiation factor 6
 18785
 0.21
chr6_149144321_149144479 1.13 Etfbkmt
 electron transfer flavoprotein beta subunit lysine methyltransferase
 2754
 0.18
chr4_137795816_137796289 0.96 Alpl
 alkaline phosphatase, liver/bone/kidney
 178
 0.96
chr7_121981237_121981388 0.91 Cog7
 component of oligomeric golgi complex 7
 382
 0.51
chr2_160715771_160715932 0.65 Top1
 topoisomerase (DNA) I
 1618
 0.36
chr2_134544863_134545049 0.52 Hao1
 hydroxyacid oxidase 1, liver
 9351
 0.3
chr11_16817302_16817617 0.46 Egfros
 epidermal growth factor receptor, opposite strand
 13243
 0.21
chr15_98092785_98093187 0.44 Senp1
 SUMO1/sentrin specific peptidase 1
 99
 0.64
chr2_134795038_134795224 0.43 Plcb1
 phospholipase C, beta 1
 8601
 0.19
chr10_95415293_95415489 0.43 Socs2
 suppressor of cytokine signaling 2
 93
 0.95
chrX_140538959_140539298 0.42 Tsc22d3
 TSC22 domain family, member 3
 3540
 0.25
chr5_53277740_53277949 0.37 Smim20
 small integral membrane protein 20
 726
 0.65
chr4_3835532_3835858 0.37 Rps20
 ribosomal protein S20
 30
 0.9
chr1_100410526_100410677 0.35 Gm29667
 predicted gene 29667
 127810
 0.05
chr6_117360618_117360785 0.34 Gm4640
 predicted gene 4640
 62916
 0.12
chr16_34047934_34048195 0.34 Kalrn
 kalirin, RhoGEF kinase
 31570
 0.17
chr6_136906748_136907166 0.33 Erp27
 endoplasmic reticulum protein 27
 15183
 0.11
chr2_43522117_43522300 0.33 Gm13464
 predicted gene 13464
 2810
 0.36
chr9_36726566_36726754 0.32 Chek1
 checkpoint kinase 1
 2
 0.96
chr11_78115153_78115348 0.32 Fam222b
 family with sequence similarity 222, member B
 356
 0.73
chr5_22587487_22587999 0.31 Gm9057
 predicted gene 9057
 23786
 0.11
chr4_84545854_84546088 0.31 Bnc2
 basonuclin 2
 319
 0.94
chr11_117810052_117810409 0.31 Syngr2
 synaptogyrin 2
 518
 0.39
chr8_35582440_35582591 0.30 Mfhas1
 malignant fibrous histiocytoma amplified sequence 1
 5283
 0.21
chr13_101719143_101719316 0.30 Pik3r1
 phosphoinositide-3-kinase regulatory subunit 1
 17125
 0.2
chr3_121801857_121802086 0.30 Abcd3
 ATP-binding cassette, sub-family D (ALD), member 3
 12938
 0.12
chr10_87030293_87030475 0.29 Stab2
 stabilin 2
 22359
 0.14
chr5_124172698_124172925 0.29 Pitpnm2
 phosphatidylinositol transfer protein, membrane-associated 2
 12307
 0.12
chr6_54046378_54046711 0.28 Chn2
 chimerin 2
 6458
 0.22
chr11_29172228_29172645 0.28 Ppp4r3b
 protein phosphatase 4 regulatory subunit 3B
 454
 0.71
chr10_68147784_68148076 0.28 Arid5b
 AT rich interactive domain 5B (MRF1-like)
 11304
 0.26
chr15_59072163_59072449 0.27 Mtss1
 MTSS I-BAR domain containing 1
 9683
 0.23
chr15_55090636_55090987 0.27 Dscc1
 DNA replication and sister chromatid cohesion 1
 320
 0.85
chr2_25195851_25196175 0.27 Tor4a
 torsin family 4, member A
 746
 0.34
chr2_18048778_18049088 0.27 Skida1
 SKI/DACH domain containing 1
 98
 0.94
chr1_175634536_175634795 0.27 Kmo
 kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)
 2426
 0.25
chr12_12941753_12942056 0.25 Mycn
 v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
 10
 0.97
chr3_34020715_34021194 0.24 Fxr1
 fragile X mental retardation gene 1, autosomal homolog
 846
 0.39
chr9_94016628_94017010 0.23 Gm5369
 predicted gene 5369
 122643
 0.06
chr8_121953313_121953464 0.23 Gm27011
 predicted gene, 27011
 2743
 0.14
chr9_64281144_64281332 0.22 Tipin
 timeless interacting protein
 343
 0.81
chrX_60825498_60825671 0.22 Gm14660
 predicted gene 14660
 7376
 0.21
chr8_112010835_112011224 0.21 Kars
 lysyl-tRNA synthetase
 237
 0.62
chr15_82266462_82266636 0.21 Septin3
 septin 3
 2253
 0.14
chr11_90389300_90389483 0.21 Hlf
 hepatic leukemia factor
 199
 0.96
chr15_57693839_57694019 0.20 Zhx2
 zinc fingers and homeoboxes 2
 736
 0.69
chr2_44113422_44113573 0.20 Arhgap15os
 Rho GTPase activating protein 15, opposite strand
 48173
 0.17
chr11_80081649_80082056 0.20 Crlf3
 cytokine receptor-like factor 3
 861
 0.55
chr14_34188761_34188924 0.20 Gm18884
 predicted gene, 18884
 12533
 0.08
chr9_96823694_96824186 0.19 Gm8520
 predicted gene 8520
 9606
 0.15
chr17_35236084_35236374 0.18 Atp6v1g2
 ATPase, H+ transporting, lysosomal V1 subunit G2
 333
 0.45
chr15_99045316_99045476 0.18 Prph
 peripherin
 9778
 0.09
chr16_78481019_78481170 0.18 Gm49603
 predicted gene, 49603
 555
 0.75
chr4_46649810_46649996 0.18 Tbc1d2
 TBC1 domain family, member 2
 306
 0.9
chr18_16608064_16608271 0.18 Cdh2
 cadherin 2
 61902
 0.14
chr11_98979666_98979817 0.18 Gjd3
 gap junction protein, delta 3
 3275
 0.14
chr11_95307677_95307905 0.18 Kat7
 K(lysine) acetyltransferase 7
 1722
 0.24
chr19_28998112_28998308 0.18 Cdc37l1
 cell division cycle 37-like 1
 1107
 0.35
chr13_93996913_93997222 0.18 Gm47216
 predicted gene, 47216
 5299
 0.2
chr4_117131265_117131506 0.18 Plk3
 polo like kinase 3
 2414
 0.1
chr5_23787902_23788378 0.17 Rint1
 RAD50 interactor 1
 399
 0.71
chr10_47582131_47582287 0.17 Gm47571
 predicted gene, 47571
 57914
 0.17
chr3_136428039_136428202 0.16 1700030L20Rik
 RIKEN cDNA 1700030L20 gene
 21229
 0.23
chr15_78845338_78845568 0.16 Cdc42ep1
 CDC42 effector protein (Rho GTPase binding) 1
 2829
 0.13
chr4_145229848_145230015 0.16 Tnfrsf1b
 tumor necrosis factor receptor superfamily, member 1b
 16939
 0.19
chr13_112196528_112196688 0.16 Gm37427
 predicted gene, 37427
 22585
 0.16
chr2_84744034_84744230 0.16 Gm19426
 predicted gene, 19426
 477
 0.61
chr11_26386927_26387278 0.15 Fancl
 Fanconi anemia, complementation group L
 100
 0.97
chr1_67099324_67099498 0.15 Cps1
 carbamoyl-phosphate synthetase 1
 23615
 0.2
chrX_150594237_150594425 0.15 Pfkfb1
 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1
 147
 0.94
chr16_70354766_70354917 0.15 Gbe1
 glucan (1,4-alpha-), branching enzyme 1
 40707
 0.19
chr11_79992533_79993138 0.15 Suz12
 SUZ12 polycomb repressive complex 2 subunit
 271
 0.91
chr3_51229561_51229725 0.15 Gm38357
 predicted gene, 38357
 2274
 0.22
chr4_120825407_120825586 0.15 Nfyc
 nuclear transcription factor-Y gamma
 188
 0.91
chr19_40158669_40158820 0.15 Cyp2c70
 cytochrome P450, family 2, subfamily c, polypeptide 70
 28542
 0.13
chr1_192812225_192812480 0.15 Gm38360
 predicted gene, 38360
 8775
 0.14
chr15_75205125_75205276 0.15 Gm28117
 predicted gene 28117
 7533
 0.12
chr14_47242891_47243067 0.14 Wdhd1
 WD repeat and HMG-box DNA binding protein 1
 2291
 0.15
chr16_34824937_34825201 0.14 Mylk
 myosin, light polypeptide kinase
 40148
 0.18
chr19_6305879_6306268 0.14 Cdc42bpg
 CDC42 binding protein kinase gamma (DMPK-like)
 383
 0.68
chr7_102065637_102065828 0.14 Xntrpc
 Xndc1-transient receptor potential cation channel, subfamily C, member 2 readthrough
 19
 0.44
chr2_165070502_165070653 0.14 Cd40
 CD40 antigen
 7901
 0.15
chr16_38293144_38293465 0.14 Nr1i2
 nuclear receptor subfamily 1, group I, member 2
 1520
 0.32
chr10_10836079_10836268 0.13 4930567K20Rik
 RIKEN cDNA 4930567K20 gene
 85093
 0.08
chr4_43010254_43010416 0.13 Fancg
 Fanconi anemia, complementation group G
 20
 0.95
chr2_33370578_33371002 0.13 Ralgps1
 Ral GEF with PH domain and SH3 binding motif 1
 639
 0.68
chr11_55204467_55204772 0.13 Slc36a1
 solute carrier family 36 (proton/amino acid symporter), member 1
 243
 0.9
chr13_51073365_51073844 0.13 Spin1
 spindlin 1
 27276
 0.21
chr9_102721358_102721856 0.13 Amotl2
 angiomotin-like 2
 709
 0.56
chr10_43312960_43313230 0.12 Gm16546
 predicted gene 16546
 6265
 0.19
chrX_77810630_77810940 0.12 Gm14742
 predicted gene 14742
 7505
 0.16
chr6_145865754_145865981 0.12 Bhlhe41
 basic helix-loop-helix family, member e41
 309
 0.87
chr8_105881480_105881631 0.12 Edc4
 enhancer of mRNA decapping 4
 478
 0.59
chr8_128446539_128446690 0.12 Nrp1
 neuropilin 1
 87217
 0.09
chr4_108064276_108064464 0.11 Scp2
 sterol carrier protein 2, liver
 6993
 0.14
chr18_53859942_53860093 0.11 Csnk1g3
 casein kinase 1, gamma 3
 2105
 0.44
chr11_31888267_31888568 0.11 Cpeb4
 cytoplasmic polyadenylation element binding protein 4
 15142
 0.2
chr10_19552959_19553256 0.11 Gm48563
 predicted gene, 48563
 30457
 0.15
chr1_51879717_51879868 0.11 Gm28323
 predicted gene 28323
 184
 0.93
chr17_64205783_64206178 0.11 Pja2
 praja ring finger ubiquitin ligase 2
 107051
 0.07
chr1_161260611_161260770 0.11 Prdx6
 peroxiredoxin 6
 9471
 0.17
chr2_150778031_150778205 0.11 Pygb
 brain glycogen phosphorylase
 8617
 0.15
chr17_15423433_15423758 0.11 Gm49668
 predicted gene, 49668
 11369
 0.13
chr9_103349628_103349779 0.11 Topbp1
 topoisomerase (DNA) II binding protein 1
 3475
 0.19
chr13_21783769_21783949 0.11 H3c11
 H3 clustered histone 11
 489
 0.44
chr1_69108079_69108251 0.10 Erbb4
 erb-b2 receptor tyrosine kinase 4
 106
 0.96
chr13_89551647_89551801 0.10 Hapln1
 hyaluronan and proteoglycan link protein 1
 11928
 0.23
chr5_20589642_20589807 0.10 Gm3544
 predicted gene 3544
 1128
 0.56
chr4_150740556_150740736 0.10 Gm16079
 predicted gene 16079
 61854
 0.1
chr16_17125381_17125599 0.10 2610318N02Rik
 RIKEN cDNA 2610318N02 gene
 323
 0.64
chr3_18624191_18624481 0.10 Gm42944
 predicted gene 42944
 2174
 0.32
chr16_10834941_10835111 0.10 Rmi2
 RecQ mediated genome instability 2
 33
 0.95
chr4_125451423_125451580 0.10 Grik3
 glutamate receptor, ionotropic, kainate 3
 39199
 0.16
chr2_51143066_51143386 0.10 Rnd3
 Rho family GTPase 3
 5868
 0.27
chr1_71649974_71650188 0.09 Apol7d
 apolipoprotein L 7d
 2756
 0.24
chr8_23436686_23436866 0.09 Sfrp1
 secreted frizzled-related protein 1
 25274
 0.22
chr18_12861326_12861482 0.09 Osbpl1a
 oxysterol binding protein-like 1A
 199
 0.89
chr11_16820788_16820939 0.09 Egfros
 epidermal growth factor receptor, opposite strand
 9839
 0.22
chr3_96700485_96700645 0.09 Pias3
 protein inhibitor of activated STAT 3
 87
 0.92
chr14_99100245_99100396 0.09 Pibf1
 progesterone immunomodulatory binding factor 1
 362
 0.61
chr5_125173585_125173942 0.09 Ncor2
 nuclear receptor co-repressor 2
 5290
 0.24
chr6_83421822_83421997 0.09 5430434F05Rik
 RIKEN cDNA 5430434F05 gene
 917
 0.44
chrX_159255089_159255806 0.09 Rps6ka3
 ribosomal protein S6 kinase polypeptide 3
 335
 0.92
chr13_12457926_12458454 0.09 Lgals8
 lectin, galactose binding, soluble 8
 1667
 0.31
chr1_131276568_131276872 0.09 Ikbke
 inhibitor of kappaB kinase epsilon
 7
 0.96
chr17_32205448_32205665 0.09 Brd4
 bromodomain containing 4
 4548
 0.14
chr7_64497544_64497716 0.09 Apba2
 amyloid beta (A4) precursor protein-binding, family A, member 2
 4076
 0.21
chr17_71598268_71598610 0.08 Trmt61b
 tRNA methyltransferase 61B
 186
 0.89
chr13_24316648_24316847 0.08 Gm23340
 predicted gene, 23340
 105
 0.94
chr16_16146290_16146715 0.08 Spidr
 scaffolding protein involved in DNA repair
 302
 0.91
chr10_17531063_17531258 0.08 Gm47770
 predicted gene, 47770
 4246
 0.22
chr6_116092433_116092702 0.08 Gm20404
 predicted gene 20404
 15083
 0.15
chr14_70351659_70351817 0.08 Slc39a14
 solute carrier family 39 (zinc transporter), member 14
 313
 0.84
chr17_25792594_25792983 0.08 Fam173a
 family with sequence similarity 173, member A
 10
 0.9
chr5_140783617_140783781 0.08 Amz1
 archaelysin family metallopeptidase 1
 34416
 0.14
chr3_95218073_95218246 0.08 Gabpb2
 GA repeat binding protein, beta 2
 243
 0.72
chr1_151178576_151178751 0.07 Gm47985
 predicted gene, 47985
 3874
 0.14
chr15_57912367_57912734 0.07 Tbc1d31
 TBC1 domain family, member 31
 311
 0.9
chr6_113624952_113625185 0.07 Vhl
 von Hippel-Lindau tumor suppressor
 139
 0.89
chr1_179108579_179108982 0.07 Smyd3
 SET and MYND domain containing 3
 119435
 0.06
chr6_15721066_15721382 0.07 Mdfic
 MyoD family inhibitor domain containing
 137
 0.98
chr18_32556472_32556888 0.07 Gypc
 glycophorin C
 3300
 0.27
chr16_33381984_33382411 0.07 Zfp148
 zinc finger protein 148
 579
 0.7
chr1_45795644_45795998 0.07 Wdr75
 WD repeat domain 75
 314
 0.86
chrX_85112549_85112727 0.07 Dmd
 dystrophin, muscular dystrophy
 64225
 0.13
chr12_111114376_111114527 0.07 Gm48632
 predicted gene, 48632
 23251
 0.13
chr9_57064508_57064675 0.07 Ptpn9
 protein tyrosine phosphatase, non-receptor type 9
 5153
 0.14
chrX_113185187_113185419 0.07 Chm
 choroidermia (RAB escort protein 1)
 206
 0.95
chr6_115717866_115718504 0.06 Gm24008
 predicted gene, 24008
 5647
 0.12
chr6_54051509_54051688 0.06 Chn2
 chimerin 2
 11512
 0.21
chr11_54860913_54861249 0.06 Lyrm7
 LYR motif containing 7
 165
 0.93
chr4_43000782_43000941 0.06 Vcp
 valosin containing protein
 354
 0.76
chr1_140267167_140267318 0.06 Gm37777
 predicted gene, 37777
 755
 0.71
chr16_7100033_7100384 0.06 Rbfox1
 RNA binding protein, fox-1 homolog (C. elegans) 1
 30362
 0.27
chr6_37440535_37440868 0.06 Creb3l2
 cAMP responsive element binding protein 3-like 2
 1445
 0.53
chr19_55895196_55895361 0.06 Tcf7l2
 transcription factor 7 like 2, T cell specific, HMG box
 232
 0.95
chr13_30338451_30338663 0.06 Agtr1a
 angiotensin II receptor, type 1a
 2113
 0.34
chr16_17619254_17619416 0.06 Smpd4
 sphingomyelin phosphodiesterase 4
 19
 0.96
chr3_88497845_88497996 0.06 Lmna
 lamin A
 4608
 0.09
chr2_130905756_130906591 0.06 A730017L22Rik
 RIKEN cDNA A730017L22 gene
 183
 0.45
chr17_32272780_32272931 0.06 Brd4
 bromodomain containing 4
 490
 0.72
chr16_92465382_92465533 0.06 Rcan1
 regulator of calcineurin 1
 686
 0.61
chr11_102318700_102318851 0.06 Ubtf
 upstream binding transcription factor, RNA polymerase I
 321
 0.8
chr2_17423032_17423195 0.05 Nebl
 nebulette
 32105
 0.23
chr11_79253815_79253989 0.05 Wsb1
 WD repeat and SOCS box-containing 1
 568
 0.72
chr5_132546141_132546320 0.05 Gm42626
 predicted gene 42626
 174
 0.91
chr8_94358704_94358868 0.05 Slc12a3
 solute carrier family 12, member 3
 2475
 0.16
chrX_19166759_19167084 0.05 Gm14636
 predicted gene 14636
 311
 0.9
chr9_22003120_22003482 0.05 Prkcsh
 protein kinase C substrate 80K-H
 84
 0.88
chr5_149007925_149008200 0.05 Gm15408
 predicted gene 15408
 1100
 0.3
chr15_80977693_80977853 0.05 Sgsm3
 small G protein signaling modulator 3
 6
 0.96
chr9_32541639_32541830 0.05 Fli1
 Friend leukemia integration 1
 139
 0.93
chr4_95737745_95737908 0.05 Fggy
 FGGY carbohydrate kinase domain containing
 582
 0.84
chr18_74794198_74794360 0.05 Acaa2
 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
 896
 0.53
chr8_109737758_109738093 0.05 Atxn1l
 ataxin 1-like
 186
 0.93
chr12_59060973_59061324 0.05 Trappc6b
 trafficking protein particle complex 6B
 196
 0.9
chr4_137942824_137943002 0.04 Ece1
 endothelin converting enzyme 1
 29231
 0.17
chr10_122679401_122679658 0.04 Mir8104
 microRNA 8104
 214
 0.84
chr15_55557483_55557916 0.04 Mtbp
 Mdm2, transformed 3T3 cell double minute p53 binding protein
 36
 0.51
chr2_122070032_122070198 0.04 Eif3j1
 eukaryotic translation initiation factor 3, subunit J1
 41463
 0.1
chr11_16796275_16796460 0.04 Egfros
 epidermal growth factor receptor, opposite strand
 34335
 0.15
chr1_128102401_128102560 0.04 Zranb3
 zinc finger, RAN-binding domain containing 3
 17
 0.91
chr1_128359683_128359850 0.04 Mcm6
 minichromosome maintenance complex component 6
 102
 0.96
chr16_22263821_22263972 0.04 Tra2b
 transformer 2 beta
 2004
 0.22
chr19_37561242_37561423 0.04 Exoc6
 exocyst complex component 6
 10873
 0.21
chr19_46503050_46503201 0.04 Trim8
 tripartite motif-containing 8
 1423
 0.35
chr15_81522098_81522372 0.04 Gm5218
 predicted gene 5218
 22690
 0.11
chr6_122872904_122873082 0.04 Necap1
 NECAP endocytosis associated 1
 1481
 0.27
chr8_109991339_109991991 0.04 Tat
 tyrosine aminotransferase
 1159
 0.36
chr11_79712044_79712202 0.04 Mir193a
 microRNA 193a
 154
 0.93
chr12_80949222_80949570 0.04 Srsf5
 serine and arginine-rich splicing factor 5
 3020
 0.17
chr13_101349484_101349644 0.04 Gm2534
 predicted gene 2534
 812
 0.69
chr2_90545522_90545673 0.04 Ptprj
 protein tyrosine phosphatase, receptor type, J
 35050
 0.16
chr8_46376394_46376573 0.04 Gm45253
 predicted gene 45253
 9405
 0.14
chr17_4907841_4908226 0.03 4930579D07Rik
 RIKEN cDNA 4930579D07 gene
 15046
 0.19
chr1_71102457_71102615 0.03 Bard1
 BRCA1 associated RING domain 1
 610
 0.8
chr16_24151105_24151294 0.03 Gm32126
 predicted gene, 32126
 17362
 0.19
chr2_105932157_105932324 0.03 Immp1l
 IMP1 inner mitochondrial membrane peptidase-like (S. cerevisiae)
 27602
 0.13
chr2_30042566_30042728 0.03 Wdr34
 WD repeat domain 34
 6214
 0.11
chr13_9494911_9495081 0.03 Gm48871
 predicted gene, 48871
 49096
 0.12

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of E2f8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0034421 post-translational protein acetylation(GO:0034421)
0.1 0.3 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.2 GO:0048478 replication fork protection(GO:0048478)
0.1 0.3 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0070672 response to interleukin-15(GO:0070672)
0.0 0.1 GO:0015959 diadenosine polyphosphate metabolic process(GO:0015959)
0.0 0.5 GO:0060396 growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0 0.1 GO:0019805 quinolinate biosynthetic process(GO:0019805)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 0.9 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0 0.2 GO:0001561 fatty acid alpha-oxidation(GO:0001561)
0.0 0.1 GO:0033133 positive regulation of glucokinase activity(GO:0033133)
0.0 0.1 GO:0042518 negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0 0.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 0.1 GO:0015808 L-alanine transport(GO:0015808)
0.0 0.2 GO:0045631 regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0 0.1 GO:0048239 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.0 0.1 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0 0.1 GO:1902071 regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0 0.1 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0 0.1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.1 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.5 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.0 0.1 GO:0061366 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.1 GO:0042525 tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0 0.3 GO:1900745 positive regulation of p38MAPK cascade(GO:1900745)
0.0 0.1 GO:2000152 regulation of ubiquitin-specific protease activity(GO:2000152)
0.0 0.1 GO:0061622 glycolytic process through glucose-1-phosphate(GO:0061622)
0.0 0.3 GO:0003416 endochondral bone growth(GO:0003416)
0.0 0.1 GO:0072757 cellular response to camptothecin(GO:0072757)
0.0 0.0 GO:0042908 xenobiotic transport(GO:0042908)
0.0 0.0 GO:0006106 fumarate metabolic process(GO:0006106)
0.0 0.1 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.0 0.0 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0 0.1 GO:2000637 positive regulation of gene silencing by miRNA(GO:2000637)
0.0 0.0 GO:0006362 transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0 0.1 GO:0060628 regulation of ER to Golgi vesicle-mediated transport(GO:0060628)
0.0 0.1 GO:0060613 fat pad development(GO:0060613)
0.0 0.1 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.9 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.0 0.2 GO:0031298 replication fork protection complex(GO:0031298)
0.0 0.5 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.1 GO:0070939 Dsl1p complex(GO:0070939)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.3 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.0 0.1 GO:0005945 6-phosphofructokinase complex(GO:0005945)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.0 0.1 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.1 GO:0030891 VCB complex(GO:0030891)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0030870 Mre11 complex(GO:0030870)
0.0 0.1 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.9 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 0.3 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 0.4 GO:0005131 growth hormone receptor binding(GO:0005131)
0.1 0.3 GO:0035184 histone threonine kinase activity(GO:0035184)
0.1 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 0.2 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.0 0.2 GO:0016899 oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0 0.2 GO:0043426 MRF binding(GO:0043426)
0.0 0.1 GO:0036435 K48-linked polyubiquitin binding(GO:0036435)
0.0 0.1 GO:0005280 hydrogen:amino acid symporter activity(GO:0005280)
0.0 0.1 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.1 GO:0048408 epidermal growth factor binding(GO:0048408)
0.0 0.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0 0.1 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
0.0 0.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.1 GO:0016822 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.1 GO:0038132 neuregulin binding(GO:0038132)
0.0 0.1 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.0 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0 0.1 GO:0030957 Tat protein binding(GO:0030957)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0 0.3 PID BARD1 PATHWAY BARD1 signaling events
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.2 PID ERBB NETWORK PATHWAY ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.4 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.0 0.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.0 0.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.0 0.1 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.0 0.2 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.0 0.0 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 0.1 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling