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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Egr4

Z-value: 1.00

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Transcription factors associated with Egr4

Gene Symbol	Gene ID	Gene Info
Egr4 Ensembl NCBI MGI UniProt	ENSMUSG00000071341.3	Egr4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Egr4	chr6_85510591_85510748	2920	0.175543	0.42	4.1e-01	Click!

Activity of the Egr4 motif across conditions

Conditions sorted by the z-value of the Egr4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_125569857_125570144	4.42	Sipa1l2	signal-induced proliferation-associated 1 like 2	192	0.96
chr9_48984872_48985421	3.34	Usp28	ubiquitin specific peptidase 28	229	0.92
chrX_12761746_12762400	1.17	Med14	mediator complex subunit 14	0	0.73
chr11_75173089_75173918	1.13	Mir212	microRNA 212	115	0.56
chr14_120830490_120830770	0.93	Gm9391	predicted gene 9391	3472	0.2
chr9_89199094_89199252	0.90	Bcl2a1b	B cell leukemia/lymphoma 2 related protein A1b	36	0.71
chr10_80343063_80343448	0.87	Adamtsl5	ADAMTS-like 5	1983	0.12
chrX_9272438_9272819	0.84	Xk	X-linked Kx blood group	128	0.94
chr1_182763696_182764002	0.82	Susd4	sushi domain containing 4	11	0.98
chr9_107986066_107986266	0.80	Inka1	inka box actin regulator 1	287	0.67
chr15_96494191_96494357	0.71	Gm41392	predicted gene, 41392	303	0.91
chr12_76370132_76370629	0.71	Zbtb1	zinc finger and BTB domain containing 1	114	0.89
chr19_46328692_46329074	0.69	Fbxl15	F-box and leucine-rich repeat protein 15	696	0.41
chr8_122324060_122324293	0.68	Zfpm1	zinc finger protein, multitype 1	9522	0.13
chrX_123103386_123103718	0.67	Cldn34c1	claudin 34C1	2	0.98
chr3_145924039_145924997	0.62	Bcl10	B cell leukemia/lymphoma 10	161	0.95
chr5_142938438_142938600	0.57	Fscn1	fascin actin-bundling protein 1	21824	0.13
chr6_85431886_85432060	0.56	Smyd5	SET and MYND domain containing 5	16	0.96
chr17_24470568_24470947	0.55	Pgp	phosphoglycolate phosphatase	322	0.51
chr1_36939852_36940044	0.55	Tmem131	transmembrane protein 131	126	0.95
chr11_97883591_97883758	0.55	Fbxo47	F-box protein 47	480	0.58
chr10_60346558_60346709	0.55	Vsir	V-set immunoregulatory receptor	218	0.94
chr3_108257311_108257615	0.54	1700010K24Rik	RIKEN cDNA 1700010K24 gene	478	0.42
chr17_35667522_35667701	0.54	Vars2	valyl-tRNA synthetase 2, mitochondrial	19	0.92
chr6_128799156_128799331	0.53	Klrb1c	killer cell lectin-like receptor subfamily B member 1C	10028	0.1
chr10_79897700_79897893	0.53	Med16	mediator complex subunit 16	1889	0.11
chr2_124609977_124610547	0.53	Sema6d	sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6D	34	0.99
chr15_97908200_97908485	0.52	Vdr	vitamin D (1,25-dihydroxyvitamin D3) receptor	32	0.98
chr2_156008335_156008486	0.51	Ergic3	ERGIC and golgi 3	187	0.72
chr1_153424966_153425246	0.51	Shcbp1l	Shc SH2-domain binding protein 1-like	56	0.96
chr3_52267780_52268128	0.49	Foxo1	forkhead box O1	382	0.75
chr7_25395891_25396191	0.49	Lipe	lipase, hormone sensitive	338	0.61
chr9_20521562_20521965	0.49	Zfp266	zinc finger protein 266	346	0.81
chr10_17948008_17948419	0.48	Heca	hdc homolog, cell cycle regulator	146	0.97
chr2_155390028_155390312	0.47	Ncoa6	nuclear receptor coactivator 6	6656	0.14
chr17_34958907_34959139	0.46	Hspa1b	heat shock protein 1B	215	0.75
chr14_50924662_50925001	0.46	Osgep	O-sialoglycoprotein endopeptidase	1	0.62
chr2_27284271_27284473	0.46	Vav2	vav 2 oncogene	5493	0.18
chr11_75170209_75170498	0.45	Hic1	hypermethylated in cancer 1	834	0.37
chr15_79927724_79927894	0.45	Cbx7	chromobox 7	4707	0.14
chr1_132007861_132008160	0.45	Elk4	ELK4, member of ETS oncogene family	89	0.96
chr13_58157546_58157700	0.44	Idnk	idnK gluconokinase homolog (E. coli)	26	0.51
chr16_17928117_17928461	0.44	Slc25a1	solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1	70	0.94
chr1_130715772_130716198	0.43	Pfkfb2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2	171	0.49
chr6_48086500_48086790	0.42	Zfp746	zinc finger protein 746	52	0.97
chr11_61684235_61684526	0.42	Fam83g	family with sequence similarity 83, member G	39	0.97
chr4_141060479_141060918	0.42	Crocc	ciliary rootlet coiled-coil, rootletin	148	0.92
chr19_44393747_44393961	0.41	Scd1	stearoyl-Coenzyme A desaturase 1	12836	0.14
chr9_55283614_55283814	0.40	Nrg4	neuregulin 4	89	0.97
chr7_18990506_18990869	0.40	Mypop	Myb-related transcription factor, partner of profilin	558	0.49
chr7_64048693_64048852	0.40	Gm45054	predicted gene 45054	7946	0.16
chr9_88731798_88731969	0.40	Bcl2a1d	B cell leukemia/lymphoma 2 related protein A1d	31	0.59
chr14_65667090_65667241	0.40	Scara5	scavenger receptor class A, member 5	728	0.73
chr4_129618572_129618944	0.40	Iqcc	IQ motif containing C	318	0.73
chr4_119138309_119138481	0.39	Gm12868	predicted gene 12868	406	0.71
chr17_26138333_26138708	0.39	Axin1	axin 1	168	0.88
chr3_55112219_55112827	0.38	Spg20	spastic paraplegia 20, spartin (Troyer syndrome) homolog (human)	73	0.97
chr6_136449342_136449720	0.38	Gm25882	predicted gene, 25882	31719	0.1
chr17_34971805_34972034	0.37	Hspa1a	heat shock protein 1A	237	0.66
chr8_75213035_75213232	0.37	Rasd2	RASD family, member 2	811	0.58
chr15_8168911_8169078	0.37	Cplane1	ciliogenesis and planar polarity effector 1	112	0.97
chr2_180589339_180589504	0.37	Ogfr	opioid growth factor receptor	41	0.96
chr15_88832888_88833102	0.37	Gm23144	predicted gene, 23144	2305	0.21
chr10_80577672_80578424	0.37	Klf16	Kruppel-like factor 16	727	0.41
chr4_106463187_106463359	0.36	Pcsk9	proprotein convertase subtilisin/kexin type 9	1056	0.45
chr7_127876515_127876679	0.36	Zfp668	zinc finger protein 668	180	0.49
chr5_140389137_140389453	0.36	Snx8	sorting nexin 8	33	0.97
chr6_124965028_124965351	0.36	Cops7a	COP9 signalosome subunit 7A	18	0.92
chr10_77902990_77903176	0.36	Lrrc3	leucine rich repeat containing 3	547	0.54
chr17_35186094_35186252	0.36	Lst1	leukocyte specific transcript 1	2266	0.07
chr8_70792935_70793116	0.36	Mast3	microtubule associated serine/threonine kinase 3	588	0.47
chr4_47352960_47353255	0.36	Tgfbr1	transforming growth factor, beta receptor I	115	0.97
chr10_4432270_4432710	0.35	Armt1	acidic residue methyltransferase 1	23	0.58
chr4_101647910_101648061	0.35	Leprot	leptin receptor overlapping transcript	192	0.96
chr4_149517672_149517903	0.35	Ctnnbip1	catenin beta interacting protein 1	449	0.45
chr3_145790177_145790690	0.35	Ddah1	dimethylarginine dimethylaminohydrolase 1	20046	0.19
chr1_183345405_183345565	0.34	Mia3	melanoma inhibitory activity 3	29	0.97
chr18_35272122_35272298	0.34	Gm50146	predicted gene, 50146	8181	0.17
chr10_81167707_81168009	0.34	Pias4	protein inhibitor of activated STAT 4	65	0.92
chr7_19404092_19404290	0.33	Klc3	kinesin light chain 3	87	0.85
chr19_28834565_28834716	0.32	Slc1a1	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1	409	0.82
chr18_46597468_46597778	0.32	Eif1a	eukaryotic translation initiation factor 1A	78	0.5
chr13_32802244_32802687	0.32	Wrnip1	Werner helicase interacting protein 1	349	0.49
chr11_71018794_71019067	0.32	Derl2	Der1-like domain family, member 2	282	0.7
chr18_5819758_5819934	0.32	Zeb1	zinc finger E-box binding homeobox 1	88765	0.08
chr1_133609970_133610131	0.31	Snrpe	small nuclear ribonucleoprotein E	3	0.97
chr5_53995353_53995770	0.31	Stim2	stromal interaction molecule 2	2938	0.33
chr5_47983016_47983183	0.31	Slit2	slit guidance ligand 2	39	0.97
chr16_4913847_4914003	0.31	Mgrn1	mahogunin, ring finger 1	714	0.53
chr15_76576499_76576688	0.31	Adck5	aarF domain containing kinase 5	119	0.88
chr7_19629444_19629613	0.30	Relb	avian reticuloendotheliosis viral (v-rel) oncogene related B	90	0.93
chr7_80689221_80689503	0.30	Crtc3	CREB regulated transcription coactivator 3	485	0.79
chr4_135433737_135434028	0.30	Rcan3	regulator of calcineurin 3	29	0.95
chr11_96075628_96076164	0.30	Atp5g1	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C1 (subunit 9)	226	0.86
chr11_98005250_98005423	0.30	Cacnb1	calcium channel, voltage-dependent, beta 1 subunit	7215	0.09
chr17_31386046_31386544	0.29	Pde9a	phosphodiesterase 9A	1	0.97
chr12_69680699_69681071	0.29	Sos2	SOS Ras/Rho guanine nucleotide exchange factor 2	742	0.62
chr18_35598506_35598676	0.29	Gm50163	predicted gene, 50163	18	0.49
chr5_98329132_98329560	0.29	Cfap299	cilia and flagella associated protein 299	5	0.98
chr5_136244667_136245141	0.29	Sh2b2	SH2B adaptor protein 2	1	0.97
chr1_179668115_179668496	0.29	Sccpdh	saccharopine dehydrogenase (putative)	45	0.98
chr7_29211431_29211967	0.29	Catsperg1	cation channel sperm associated auxiliary subunit gamma 1	204	0.86
chr6_137386444_137386618	0.29	Ptpro	protein tyrosine phosphatase, receptor type, O	24190	0.21
chr5_99252774_99253080	0.29	Rasgef1b	RasGEF domain family, member 1B	0	0.98
chr9_50659707_50659907	0.29	Dlat	dihydrolipoamide S-acetyltransferase (E2 component of pyruvate dehydrogenase complex)	27	0.96
chr12_102439744_102439900	0.29	Lgmn	legumain	9	0.98
chr10_108435314_108435492	0.28	Gm36283	predicted gene, 36283	1262	0.46
chr17_35978974_35979125	0.28	Prr3	proline-rich polypeptide 3	78	0.87
chr7_38084831_38085137	0.28	Ccne1	cyclin E1	14385	0.15
chr12_8674756_8674907	0.27	Pum2	pumilio RNA-binding family member 2	66	0.98
chr14_45657978_45658304	0.27	Ddhd1	DDHD domain containing 1	1	0.56
chr6_128760422_128760580	0.27	Gm43907	predicted gene, 43907	15857	0.1
chr4_76360819_76360981	0.27	Ptprd	protein tyrosine phosphatase, receptor type, D	16657	0.23
chr7_80370643_80370981	0.27	Man2a2	mannosidase 2, alpha 2	46	0.95
chr6_39725291_39725442	0.27	Braf	Braf transforming gene	97	0.97
chr8_94876377_94876534	0.27	Dok4	docking protein 4	125	0.93
chr19_61226929_61227456	0.27	Csf2ra	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	44	0.96
chr13_55105166_55105330	0.27	Zfp346	zinc finger protein 346	63	0.96
chr12_5375671_5375936	0.27	2810032G03Rik	RIKEN cDNA 2810032G03 gene	67	0.57
chr11_95337319_95337527	0.26	Gm11521	predicted gene 11521	15	0.86
chr17_28523067_28523337	0.26	Gm20109	predicted gene, 20109	54	0.53
chr13_34874226_34874546	0.26	Prpf4b	pre-mRNA processing factor 4B	916	0.34
chr4_63216606_63216811	0.26	Col27a1	collagen, type XXVII, alpha 1	1273	0.43
chr12_17691350_17691514	0.26	Hpcal1	hippocalcin-like 1	576	0.8
chr18_67768082_67768255	0.26	Gm26910	predicted gene, 26910	6689	0.15
chr12_110446490_110446665	0.26	Ppp2r5c	protein phosphatase 2, regulatory subunit B', gamma	543	0.76
chr17_29848916_29849085	0.26	Mdga1	MAM domain containing glycosylphosphatidylinositol anchor 1	1541	0.36
chr4_142015030_142015185	0.25	Fhad1	forkhead-associated (FHA) phosphopeptide binding domain 1	25	0.96
chr7_80055730_80056046	0.25	Gm44951	predicted gene 44951	19183	0.1
chr2_163750130_163750300	0.25	Ada	adenosine deaminase	24	0.98
chr3_58692272_58692637	0.25	Siah2	siah E3 ubiquitin protein ligase 2	54	0.6
chr2_169929567_169929785	0.25	AY702102	cDNA sequence AY702102	33311	0.2
chr18_46959082_46959408	0.25	Commd10	COMM domain containing 10	365	0.59
chr11_8663817_8664182	0.25	Tns3	tensin 3	536	0.87
chr17_6742196_6742355	0.25	Ezr	ezrin	546	0.75
chr17_56124312_56124572	0.24	Lrg1	leucine-rich alpha-2-glycoprotein 1	2441	0.13
chr13_108158589_108158750	0.24	Ndufaf2	NADH:ubiquinone oxidoreductase complex assembly factor 2	46	0.51
chr3_138222614_138222780	0.24	Adh7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	1226	0.36
chr15_97964312_97964525	0.24	Tmem106c	transmembrane protein 106C	148	0.95
chr1_67141728_67142108	0.24	Cps1	carbamoyl-phosphate synthetase 1	18892	0.22
chr8_3676646_3677297	0.24	Gm45231	predicted gene 45231	17	0.85
chr4_129600776_129601168	0.24	Tmem234	transmembrane protein 234	11	0.81
chr4_151801848_151802061	0.23	Camta1	calmodulin binding transcription activator 1	59696	0.12
chr4_19699207_19699375	0.23	Wwp1	WW domain containing E3 ubiquitin protein ligase 1	9702	0.21
chr18_80046692_80046991	0.23	Pard6g	par-6 family cell polarity regulator gamma	49	0.94
chr6_90543682_90543913	0.23	Aldh1l1	aldehyde dehydrogenase 1 family, member L1	6992	0.14
chr9_35175976_35176147	0.23	Dcps	decapping enzyme, scavenger	0	0.96
chr2_160731435_160731699	0.23	Plcg1	phospholipase C, gamma 1	132	0.96
chr9_72132987_72133379	0.23	Gm7863	predicted gene 7863	4596	0.13
chr7_4470400_4470562	0.23	Gm15494	predicted gene 15494	768	0.4
chr5_99630204_99630355	0.23	4930405H06Rik	RIKEN cDNA 4930405H06 gene	4443	0.18
chr17_56074581_56074743	0.23	Ubxn6	UBX domain protein 6	115	0.92
chr8_93257060_93257211	0.22	Ces1f	carboxylesterase 1F	1604	0.3
chr7_19573353_19573652	0.22	Gemin7	gem nuclear organelle associated protein 7	117	0.92
chr19_59588162_59588313	0.22	Gm18161	predicted gene, 18161	47786	0.13
chr15_55043394_55043818	0.22	Taf2	TATA-box binding protein associated factor 2	2560	0.24
chr10_75407266_75407457	0.22	Upb1	ureidopropionase, beta	403	0.84
chr4_53384770_53385134	0.22	Gm12496	predicted gene 12496	19078	0.2
chr8_92355755_92356018	0.22	Crnde	colorectal neoplasia differentially expressed (non-protein coding)	5	0.97
chr11_121061638_121061789	0.22	Sectm1b	secreted and transmembrane 1B	1590	0.2
chr3_94363287_94363473	0.22	C2cd4d	C2 calcium-dependent domain containing 4D	877	0.31
chr2_33370578_33371002	0.22	Ralgps1	Ral GEF with PH domain and SH3 binding motif 1	639	0.68
chrX_105079895_105080067	0.22	Pbdc1	polysaccharide biosynthesis domain containing 1	206	0.68
chr17_69383732_69384083	0.22	Zbtb14	zinc finger and BTB domain containing 14	67	0.79
chr15_28024715_28025200	0.22	Trio	triple functional domain (PTPRF interacting)	3	0.98
chr17_83350686_83350964	0.22	Eml4	echinoderm microtubule associated protein like 4	106	0.98
chr10_85102143_85102819	0.21	Fhl4	four and a half LIM domains 4	14	0.65
chr5_100039849_100040017	0.21	Enoph1	enolase-phosphatase 1	52	0.77
chr13_119597768_119597952	0.21	Tmem267	transmembrane protein 267	8790	0.14
chr1_181144140_181144500	0.21	Nvl	nuclear VCP-like	116	0.78
chr18_32163467_32163952	0.21	Map3k2	mitogen-activated protein kinase kinase kinase 2	513	0.7
chr10_128232239_128232414	0.21	Timeless	timeless circadian clock 1	192	0.85
chr6_117168297_117168684	0.21	Cxcl12	chemokine (C-X-C motif) ligand 12	45	0.97
chrX_134058988_134059612	0.21	Cstf2	cleavage stimulation factor, 3' pre-RNA subunit 2	11	0.97
chr6_47758577_47758728	0.20	Rpl31-ps7	ribosomal protein L31, pseudogene 7	27722	0.12
chr12_54734831_54734991	0.20	Gm24305	predicted gene, 24305	193	0.83
chr2_3702714_3702883	0.20	Fam107b	family with sequence similarity 107, member B	1215	0.43
chr7_27361465_27361626	0.20	Gm20479	predicted gene 20479	4126	0.13
chr7_16028493_16028658	0.20	Bicra	BRD4 interacting chromatin remodeling complex associated protein	19346	0.12
chr19_41482156_41482948	0.20	Lcor	ligand dependent nuclear receptor corepressor	85	0.98
chr9_30137436_30137587	0.20	Gm47677	predicted gene, 47677	30064	0.22
chr3_30855609_30856108	0.20	Gpr160	G protein-coupled receptor 160	92	0.96
chr12_54713945_54714104	0.20	Gm23804	predicted gene, 23804	194	0.82
chr11_117341816_117342087	0.19	Septin9	septin 9	9523	0.19
chr17_35254463_35254614	0.19	Mir8094	microRNA 8094	3249	0.07
chr12_98628007_98628201	0.19	Spata7	spermatogenesis associated 7	53	0.96
chr12_102308562_102308753	0.19	Rin3	Ras and Rab interactor 3	25016	0.19
chr6_88198537_88198710	0.19	Gata2	GATA binding protein 2	289	0.86
chr7_24399784_24400299	0.19	Smg9	smg-9 homolog, nonsense mediated mRNA decay factor (C. elegans)	120	0.92
chr5_3927775_3928123	0.19	Akap9	A kinase (PRKA) anchor protein (yotiao) 9	105	0.96
chr11_65787387_65787891	0.19	Map2k4	mitogen-activated protein kinase kinase 4	646	0.74
chr9_114731036_114731195	0.19	Cmtm6	CKLF-like MARVEL transmembrane domain containing 6	1	0.97
chr16_32673286_32673709	0.19	Tnk2	tyrosine kinase, non-receptor, 2	298	0.87
chr6_47772904_47773093	0.19	Rpl31-ps7	ribosomal protein L31, pseudogene 7	13376	0.13
chr6_58610800_58610960	0.19	Abcg2	ATP binding cassette subfamily G member 2 (Junior blood group)	14209	0.2
chr8_117673801_117673966	0.18	Sdr42e1	short chain dehydrogenase/reductase family 42E, member 1	194	0.92
chr4_97776562_97776976	0.18	Nfia	nuclear factor I/A	839	0.51
chr6_47664591_47664742	0.18	Gm44141	predicted gene, 44141	29369	0.16
chr11_22376520_22376679	0.18	Rpsa-ps3	ribosomal protein SA, pseudogene 3	9693	0.21
chr15_82987815_82987989	0.18	Tcf20	transcription factor 20	30	0.53

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Egr4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0002572	pro-T cell differentiation(GO:0002572)
0.2	0.8	GO:0002924	negative regulation of humoral immune response mediated by circulating immunoglobulin(GO:0002924)
0.2	0.5	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.2	0.5	GO:0010980	regulation of vitamin D 24-hydroxylase activity(GO:0010979) positive regulation of vitamin D 24-hydroxylase activity(GO:0010980)
0.2	0.8	GO:0002905	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.2	0.5	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.2	0.8	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.1	0.4	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.1	0.4	GO:0048320	axial mesoderm formation(GO:0048320)
0.1	0.5	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.1	0.3	GO:1902174	positive regulation of keratinocyte apoptotic process(GO:1902174)
0.1	0.3	GO:0046340	diacylglycerol catabolic process(GO:0046340)
0.1	0.3	GO:0006624	vacuolar protein processing(GO:0006624)
0.1	0.7	GO:0008354	germ cell migration(GO:0008354)
0.1	0.3	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.1	0.3	GO:0000101	sulfur amino acid transport(GO:0000101)
0.1	0.2	GO:0045726	positive regulation of integrin biosynthetic process(GO:0045726)
0.1	0.3	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.1	0.2	GO:0010725	regulation of primitive erythrocyte differentiation(GO:0010725)
0.1	3.1	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1	0.3	GO:0019482	beta-alanine metabolic process(GO:0019482)
0.1	1.2	GO:0014041	regulation of neuron maturation(GO:0014041)
0.1	0.4	GO:0036295	cellular response to increased oxygen levels(GO:0036295) cellular response to hyperoxia(GO:0071455)
0.1	0.3	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.1	0.2	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.1	0.3	GO:0006114	glycerol biosynthetic process(GO:0006114)
0.1	0.2	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
0.1	0.4	GO:0010457	centriole-centriole cohesion(GO:0010457)
0.1	0.4	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.1	0.3	GO:0046069	cGMP catabolic process(GO:0046069)
0.1	0.2	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.1	0.4	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.1	0.3	GO:0001922	B-1 B cell homeostasis(GO:0001922)
0.1	0.3	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.3	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011) response to granulocyte macrophage colony-stimulating factor(GO:0097012)
0.0	0.1	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.0	0.1	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.0	0.5	GO:0070932	histone H3 deacetylation(GO:0070932)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0099558	maintenance of synapse structure(GO:0099558)
0.0	0.1	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.0	0.9	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0060375	mast cell differentiation(GO:0060374) regulation of mast cell differentiation(GO:0060375)
0.0	0.2	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.2	GO:0018103	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.2	GO:0045448	regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0	0.2	GO:0033133	positive regulation of glucokinase activity(GO:0033133)
0.0	0.3	GO:0010388	cullin deneddylation(GO:0010388)
0.0	0.1	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0	0.2	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.2	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.0	0.2	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:2000383	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0	0.1	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.2	GO:2000973	regulation of pro-B cell differentiation(GO:2000973)
0.0	0.1	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.3	GO:0061732	mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
0.0	0.2	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
0.0	0.2	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.1	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.0	0.2	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.0	0.1	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.2	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.2	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:0030576	Cajal body organization(GO:0030576)
0.0	0.2	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.2	GO:0070862	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.2	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.0	0.0	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.1	GO:0002447	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.0	0.1	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:0030035	microspike assembly(GO:0030035)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
0.0	0.1	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.0	0.2	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0	0.1	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.1	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.1	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0	0.1	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.1	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.1	GO:0051697	protein delipidation(GO:0051697)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.2	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.5	GO:1902668	negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668)
0.0	0.1	GO:0015781	nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.0	GO:0033262	regulation of nuclear cell cycle DNA replication(GO:0033262)
0.0	0.2	GO:0070131	positive regulation of mitochondrial translation(GO:0070131)
0.0	3.8	GO:0051056	regulation of small GTPase mediated signal transduction(GO:0051056)
0.0	0.1	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.4	GO:0000387	spliceosomal snRNP assembly(GO:0000387)
0.0	0.2	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	1.0	GO:0006367	transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0	0.0	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	0.1	GO:2001256	regulation of store-operated calcium entry(GO:2001256)
0.0	0.1	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.2	GO:0043949	regulation of cAMP-mediated signaling(GO:0043949)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0016560	protein import into peroxisome matrix, docking(GO:0016560)
0.0	0.2	GO:0043517	positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517)
0.0	0.1	GO:1903352	ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.0	0.3	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
0.0	0.2	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.6	GO:0007339	binding of sperm to zona pellucida(GO:0007339)
0.0	0.2	GO:0002467	germinal center formation(GO:0002467)
0.0	0.1	GO:0090241	negative regulation of histone H4 acetylation(GO:0090241)
0.0	0.1	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
0.0	0.0	GO:0060178	regulation of exocyst localization(GO:0060178)
0.0	0.0	GO:0010360	negative regulation of anion channel activity(GO:0010360)
0.0	0.1	GO:0003105	negative regulation of glomerular filtration(GO:0003105)
0.0	0.0	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0051013	microtubule severing(GO:0051013)
0.0	0.1	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.0	0.0	GO:1901856	negative regulation of cellular respiration(GO:1901856)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.3	GO:0002063	chondrocyte development(GO:0002063)
0.0	0.2	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.0	0.3	GO:0015986	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	0.3	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0	0.1	GO:0030205	dermatan sulfate metabolic process(GO:0030205)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.1	GO:0006283	transcription-coupled nucleotide-excision repair(GO:0006283)
0.0	0.1	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.1	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0	0.1	GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.0	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0	0.2	GO:1900271	regulation of long-term synaptic potentiation(GO:1900271)
0.0	0.0	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.2	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.0	0.1	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.0	GO:1900060	negative regulation of sphingolipid biosynthetic process(GO:0090155) cellular sphingolipid homeostasis(GO:0090156) negative regulation of ceramide biosynthetic process(GO:1900060)
0.0	0.3	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.0	0.1	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.0	0.0	GO:0090168	Golgi reassembly(GO:0090168)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.0	GO:0010528	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0	0.1	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0	0.4	GO:0072332	intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0	0.0	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.0	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406)
0.0	0.1	GO:0030953	astral microtubule organization(GO:0030953)
0.0	0.0	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.0	GO:0045541	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.0	0.0	GO:0060154	cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0	0.0	GO:1901165	positive regulation of trophoblast cell migration(GO:1901165)
0.0	0.0	GO:0060283	negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0	0.0	GO:1903238	positive regulation of leukocyte tethering or rolling(GO:1903238)
0.0	0.0	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085) negative regulation of auditory receptor cell differentiation(GO:0045608)
0.0	0.0	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	0.1	GO:0000052	citrulline metabolic process(GO:0000052)
0.0	0.0	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.0	GO:0048478	replication fork protection(GO:0048478)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0070847	core mediator complex(GO:0070847)
0.1	0.5	GO:0001651	dense fibrillar component(GO:0001651)
0.1	0.6	GO:0046696	lipopolysaccharide receptor complex(GO:0046696)
0.1	0.3	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1	0.3	GO:0044393	microspike(GO:0044393)
0.1	0.7	GO:0035253	ciliary rootlet(GO:0035253)
0.1	0.3	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.1	0.4	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	0.5	GO:0072687	meiotic spindle(GO:0072687)
0.1	0.2	GO:0000322	storage vacuole(GO:0000322)
0.0	0.6	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.3	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.4	GO:0002199	zona pellucida receptor complex(GO:0002199)
0.0	0.3	GO:0005687	U4 snRNP(GO:0005687)
0.0	0.1	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	0.2	GO:0036128	CatSper complex(GO:0036128)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.5	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.1	GO:0030313	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.2	GO:0034719	SMN-Sm protein complex(GO:0034719)
0.0	0.7	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.1	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.2	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	1.1	GO:0005811	lipid particle(GO:0005811)
0.0	0.3	GO:0030904	retromer complex(GO:0030904)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0031464	Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.0	0.0	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.2	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.0	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:1990023	mitotic spindle midzone(GO:1990023)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0070644	vitamin D response element binding(GO:0070644)
0.2	0.5	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.1	0.3	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.1	0.3	GO:0061665	SUMO ligase activity(GO:0061665)
0.1	0.3	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.1	0.4	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.1	0.3	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.1	0.9	GO:0051400	BH domain binding(GO:0051400)
0.1	0.2	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.3	GO:0043237	laminin-1 binding(GO:0043237)
0.1	0.4	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.1	0.6	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1	0.2	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.1	0.3	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.1	0.2	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	3.4	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0	0.5	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.6	GO:0070530	K63-linked polyubiquitin binding(GO:0070530)
0.0	0.5	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.3	GO:0034603	pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
0.0	0.3	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
0.0	0.2	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.3	GO:1990446	U1 snRNP binding(GO:1990446)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.3	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.2	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.3	GO:0001223	transcription coactivator binding(GO:0001223)
0.0	0.1	GO:0008381	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.2	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.5	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.2	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.1	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.3	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.3	GO:0004000	adenosine deaminase activity(GO:0004000)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.4	GO:0004709	MAP kinase kinase kinase activity(GO:0004709)
0.0	0.3	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.1	GO:2001069	glycogen binding(GO:2001069)
0.0	0.2	GO:0034951	pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011)
0.0	0.3	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0045545	syndecan binding(GO:0045545)
0.0	0.2	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.0	0.8	GO:0019894	kinesin binding(GO:0019894)
0.0	0.3	GO:0101005	thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005)
0.0	0.1	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.2	GO:0035497	cAMP response element binding(GO:0035497)
0.0	3.8	GO:0005096	GTPase activator activity(GO:0005096)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.2	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0019145	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.4	GO:0098519	nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.0	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0	0.1	GO:0070878	primary miRNA binding(GO:0070878)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.0	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0	0.0	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.2	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.0	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.0	GO:0036033	mediator complex binding(GO:0036033)
0.0	0.0	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.1	GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934)
0.0	0.1	GO:0015189	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0	0.0	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.9	GO:0016205	rRNA (adenine-N6,N6-)-dimethyltransferase activity(GO:0000179) rRNA (uridine-2'-O-)-methyltransferase activity(GO:0008650) rRNA (adenine-N6-)-methyltransferase activity(GO:0008988) rRNA (cytosine-C5-)-methyltransferase activity(GO:0009383) selenocysteine methyltransferase activity(GO:0016205) rRNA (adenine) methyltransferase activity(GO:0016433) rRNA (cytosine) methyltransferase activity(GO:0016434) rRNA (guanine) methyltransferase activity(GO:0016435) 1-phenanthrol methyltransferase activity(GO:0018707) protein-arginine N5-methyltransferase activity(GO:0019702) dimethylarsinite methyltransferase activity(GO:0034541) 4,5-dihydroxybenzo(a)pyrene methyltransferase activity(GO:0034807) 1-hydroxypyrene methyltransferase activity(GO:0034931) 1-hydroxy-6-methoxypyrene methyltransferase activity(GO:0034933) demethylmenaquinone methyltransferase activity(GO:0043770) cobalt-precorrin-6B C5-methyltransferase activity(GO:0043776) cobalt-precorrin-7 C15-methyltransferase activity(GO:0043777) cobalt-precorrin-5B C1-methyltransferase activity(GO:0043780) cobalt-precorrin-3 C17-methyltransferase activity(GO:0043782) dimethylamine methyltransferase activity(GO:0043791) hydroxyneurosporene-O-methyltransferase activity(GO:0043803) tRNA (adenine-57, 58-N(1)-) methyltransferase activity(GO:0043827) methylamine-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043833) trimethylamine methyltransferase activity(GO:0043834) methanol-specific methylcobalamin:coenzyme M methyltransferase activity(GO:0043851) monomethylamine methyltransferase activity(GO:0043852) P-methyltransferase activity(GO:0051994) Se-methyltransferase activity(GO:0051995) 2-phytyl-1,4-naphthoquinone methyltransferase activity(GO:0052624) tRNA (uracil-2'-O-)-methyltransferase activity(GO:0052665) tRNA (cytosine-2'-O-)-methyltransferase activity(GO:0052666) phosphomethylethanolamine N-methyltransferase activity(GO:0052667) tRNA (cytosine-3-)-methyltransferase activity(GO:0052735) rRNA (cytosine-2'-O-)-methyltransferase activity(GO:0070677) rRNA (cytosine-N4-)-methyltransferase activity(GO:0071424) trihydroxyferuloyl spermidine O-methyltransferase activity(GO:0080012)
0.0	0.1	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	0.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004111	creatine kinase activity(GO:0004111)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.0	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0	0.1	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.2	GO:0052859	dextrin alpha-glucosidase activity(GO:0044653) starch alpha-glucosidase activity(GO:0044654) beta-glucanase activity(GO:0052736) beta-6-sulfate-N-acetylglucosaminidase activity(GO:0052769) glucan endo-1,4-beta-glucosidase activity(GO:0052859)
0.0	0.0	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.0	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.3	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.9	GO:0001104	RNA polymerase II transcription cofactor activity(GO:0001104)
0.0	0.0	GO:1990459	transferrin receptor binding(GO:1990459)
0.0	0.1	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.1	GO:0039706	co-receptor binding(GO:0039706)
0.0	0.0	GO:0043812	phosphatidylinositol-4-phosphate phosphatase activity(GO:0043812)
0.0	0.0	GO:0004035	alkaline phosphatase activity(GO:0004035)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.0	0.0	PID MAPK TRK PATHWAY	Trk receptor signaling mediated by the MAPK pathway
0.0	0.7	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.6	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.8	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	0.3	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	0.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.4	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.0	0.4	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.0	0.2	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.0	0.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.2	PID S1P S1P4 PATHWAY	S1P4 pathway
0.0	0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.0	0.4	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.3	REACTOME SPRY REGULATION OF FGF SIGNALING	Genes involved in Spry regulation of FGF signaling
0.6	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.5	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.5	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.5	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.3	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.3	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.3	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.5	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
0.0	REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1	Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.3	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.1	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.4	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.4	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.3	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.3	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.2	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.1	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.2	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.1	REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	Genes involved in TAK1 activates NFkB by phosphorylation and activation of IKKs complex
0.3	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.4	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.9	REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.2	REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA	Genes involved in Processing of Capped Intronless Pre-mRNA
0.1	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.2	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.3	REACTOME KINESINS	Genes involved in Kinesins
0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.2	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.2	REACTOME GLYCOLYSIS	Genes involved in Glycolysis