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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Ep300

Z-value: 0.92

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Transcription factors associated with Ep300

Gene Symbol	Gene ID	Gene Info
Ep300 Ensembl NCBI MGI UniProt	ENSMUSG00000055024.6	Ep300

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Ep300	chr15_81586343_81586511	207	0.574261	0.91	1.1e-02	Click!
Ep300	chr15_81585297_81585458	20	0.808049	0.64	1.7e-01	Click!
Ep300	chr15_81587767_81587940	1633	0.204495	-0.56	2.5e-01	Click!
Ep300	chr15_81586101_81586282	29	0.510994	0.37	4.8e-01	Click!
Ep300	chr15_81586614_81586807	490	0.446678	-0.35	4.9e-01	Click!

Activity of the Ep300 motif across conditions

Conditions sorted by the z-value of the Ep300 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_98148803_98148954	1.10	Omp	olfactory marker protein	3376	0.19
chr19_45745506_45745808	0.95	Fgf8	fibroblast growth factor 8	2742	0.18
chr11_4988618_4988782	0.66	Ap1b1	adaptor protein complex AP-1, beta 1 subunit	1766	0.27
chr7_127815913_127816268	0.63	Gm45204	predicted gene 45204	2583	0.1
chr1_133908470_133908621	0.62	Optc	opticin	546	0.66
chr2_118529366_118529517	0.61	Bmf	BCL2 modifying factor	15146	0.15
chr11_31824504_31824681	0.55	D630024D03Rik	RIKEN cDNA D630024D03 gene	68	0.97
chr7_114290333_114290662	0.53	Psma1	proteasome subunit alpha 1	14379	0.21
chr7_72498963_72499123	0.50	Gm37620	predicted gene, 37620	102946	0.07
chr8_119444266_119444532	0.49	Necab2	N-terminal EF-hand calcium binding protein 2	2320	0.23
chr1_4479698_4479869	0.47	Sox17	SRY (sex determining region Y)-box 17	13821	0.14
chr1_132587567_132587718	0.45	Nfasc	neurofascin	502	0.8
chr4_129795439_129795602	0.45	Ptp4a2	protein tyrosine phosphatase 4a2	15699	0.12
chr9_66243421_66243631	0.45	Dapk2	death-associated protein kinase 2	22779	0.2
chr7_27447795_27447954	0.45	Blvrb	biliverdin reductase B (flavin reductase (NADPH))	104	0.61
chr11_6478757_6478908	0.44	Purb	purine rich element binding protein B	2915	0.11
chr5_105698740_105698909	0.43	Lrrc8d	leucine rich repeat containing 8D	1145	0.57
chr13_28757861_28758028	0.42	Mir6368	microRNA 6368	47071	0.15
chr19_10266738_10266930	0.40	Dagla	diacylglycerol lipase, alpha	9963	0.13
chr6_119674965_119675136	0.40	Erc1	ELKS/RAB6-interacting/CAST family member 1	52945	0.15
chr19_49421746_49421913	0.39	Gm50444	predicted gene, 50444	132189	0.06
chr8_128272968_128273154	0.39	Mir21c	microRNA 21c	5164	0.3
chr5_33936341_33936510	0.39	Nelfa	negative elongation factor complex member A, Whsc2	12	0.96
chr9_118944449_118944631	0.39	Ctdspl	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	14673	0.15
chr3_9599812_9599994	0.39	Zfp704	zinc finger protein 704	10182	0.23
chr2_69228328_69228964	0.38	G6pc2	glucose-6-phosphatase, catalytic, 2	8618	0.15
chr4_155421438_155421589	0.38	5830444B04Rik	RIKEN cDNA 5830444B04 gene	182	0.71
chr8_115561082_115561286	0.37	4930488N15Rik	RIKEN cDNA 4930488N15 gene	24208	0.21
chr5_138979896_138980396	0.37	Pdgfa	platelet derived growth factor, alpha	14135	0.17
chr15_43477084_43477240	0.35	Emc2	ER membrane protein complex subunit 2	67	0.58
chr14_50981405_50981569	0.35	Gm8518	predicted gene 8518	2551	0.12
chr1_164631822_164631988	0.35	Gm37754	predicted gene, 37754	148	0.96
chr9_66802090_66802293	0.34	BC050972	cDNA sequence BC050972	368	0.78
chr15_64163681_64163861	0.34	Asap1	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	39965	0.16
chr1_72827615_72827766	0.34	Igfbp2	insulin-like growth factor binding protein 2	2368	0.33
chr10_92235111_92235286	0.34	Gm8512	predicted gene 8512	11724	0.2
chr12_84190226_84190393	0.33	Gm19327	predicted gene, 19327	2503	0.16
chr3_89422230_89422381	0.32	Shc1	src homology 2 domain-containing transforming protein C1	663	0.44
chr17_13671853_13672032	0.32	2700054A10Rik	RIKEN cDNA 2700054A10 gene	3051	0.19
chr19_23033456_23033617	0.31	Gm50136	predicted gene, 50136	27918	0.18
chr1_165617212_165617387	0.30	Mpzl1	myelin protein zero-like 1	3320	0.14
chr3_97156547_97156708	0.30	Acp6	acid phosphatase 6, lysophosphatidic	2150	0.26
chr11_57983626_57984029	0.30	Gm12249	predicted gene 12249	10693	0.15
chr11_4521480_4521785	0.29	Mtmr3	myotubularin related protein 3	6774	0.2
chr4_133169582_133169763	0.29	Wasf2	WAS protein family, member 2	6329	0.15
chr7_110689414_110689588	0.29	Gm21123	predicted gene, 21123	10233	0.15
chr3_68493220_68493423	0.29	Schip1	schwannomin interacting protein 1	170	0.96
chr16_28881932_28882083	0.28	Mb21d2	Mab-21 domain containing 2	45640	0.17
chr19_47447791_47448053	0.28	Sh3pxd2a	SH3 and PX domains 2A	16325	0.19
chr1_53931477_53931636	0.28	Gm24251	predicted gene, 24251	44615	0.15
chr7_99164655_99164806	0.27	Dgat2	diacylglycerol O-acyltransferase 2	5376	0.14
chr1_181860764_181860925	0.26	Gm5533	predicted gene 5533	7655	0.14
chr5_92112862_92113049	0.26	Gm24931	predicted gene, 24931	5328	0.13
chr6_99020013_99020438	0.26	Foxp1	forkhead box P1	7766	0.28
chr11_62538516_62538686	0.26	Cenpv	centromere protein V	28	0.95
chr15_82147771_82148080	0.26	Srebf2	sterol regulatory element binding factor 2	88	0.94
chr11_95723019_95723183	0.26	Zfp652	zinc finger protein 652	10090	0.12
chr5_117361300_117361465	0.25	Wsb2	WD repeat and SOCS box-containing 2	360	0.77
chr13_68712216_68712409	0.25	Gm26929	predicted gene, 26929	97768	0.06
chr4_98923398_98923571	0.25	Usp1	ubiquitin specific peptidase 1	326	0.89
chr11_52257389_52257568	0.25	Tcf7	transcription factor 7, T cell specific	17399	0.11
chr16_30925627_30925784	0.24	Gm46565	predicted gene, 46565	7635	0.17
chr6_129254409_129254571	0.24	2310001H17Rik	RIKEN cDNA 2310001H17 gene	15765	0.11
chr9_102864196_102864634	0.24	Ryk	receptor-like tyrosine kinase	4651	0.18
chr4_8837559_8837760	0.24	Chd7	chromodomain helicase DNA binding protein 7	2663	0.4
chr10_80823975_80824142	0.24	Oaz1	ornithine decarboxylase antizyme 1	2598	0.1
chr5_115491812_115492014	0.24	Gm13836	predicted gene 13836	542	0.51
chr3_85264828_85265142	0.24	1700036G14Rik	RIKEN cDNA 1700036G14 gene	52534	0.14
chr7_132554584_132554735	0.24	Oat	ornithine aminotransferase	21059	0.15
chr17_33524094_33524279	0.24	Adamts10	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10	18	0.97
chr2_170826881_170827076	0.23	Dok5	docking protein 5	95171	0.08
chr15_28106057_28106225	0.23	Gm31458	predicted gene, 31458	12311	0.17
chr2_126520012_126520163	0.23	Atp8b4	ATPase, class I, type 8B, member 4	19413	0.19
chr17_80728516_80728734	0.23	Map4k3	mitogen-activated protein kinase kinase kinase kinase 3	140	0.84
chr1_85526452_85526618	0.23	AC147806.2	predicted 7592	67	0.59
chr19_41829665_41829837	0.23	Frat1	frequently rearranged in advanced T cell lymphomas	219	0.91
chr7_104502188_104502379	0.23	Gm16464	predicted gene 16464	134	0.91
chr8_126656365_126656543	0.23	Irf2bp2	interferon regulatory factor 2 binding protein 2	62468	0.12
chr7_126494300_126494471	0.23	Atxn2l	ataxin 2-like	1009	0.34
chr1_85649860_85650030	0.23	Sp100	nuclear antigen Sp100	43	0.91
chr4_60503881_60504482	0.22	Gm13773	predicted gene 13773	1340	0.3
chr2_60963495_60963646	0.22	Rbms1	RNA binding motif, single stranded interacting protein 1	378	0.89
chr19_25387114_25387309	0.22	Kank1	KN motif and ankyrin repeat domains 1	8092	0.22
chr6_146933231_146933413	0.22	1700034J05Rik	RIKEN cDNA 1700034J05 gene	21092	0.14
chr17_86770158_86770337	0.22	Gm50008	predicted gene, 50008	3023	0.24
chr5_52989351_52989502	0.22	5033403H07Rik	RIKEN cDNA 5033403H07 gene	2866	0.21
chr2_84459790_84459967	0.22	Tfpi	tissue factor pathway inhibitor	1768	0.34
chr8_94186443_94186638	0.22	Gm39228	predicted gene, 39228	3251	0.13
chr11_116005461_116005624	0.22	Galk1	galactokinase 1	7177	0.1
chr17_28257108_28257273	0.21	Ppard	peroxisome proliferator activator receptor delta	14518	0.11
chr6_99171970_99172133	0.21	Foxp1	forkhead box P1	9033	0.29
chr15_55819504_55819678	0.21	Sntb1	syntrophin, basic 1	86719	0.08
chr11_49632419_49632570	0.21	Flt4	FMS-like tyrosine kinase 4	23231	0.1
chr7_128740333_128740636	0.21	Mcmbp	minichromosome maintenance complex binding protein	2	0.95
chr16_30067979_30068305	0.21	Hes1	hes family bHLH transcription factor 1	1804	0.29
chr2_165855925_165856140	0.21	BC046401	cDNA sequence BC046401	1652	0.28
chr11_70213843_70214036	0.21	Slc16a11	solute carrier family 16 (monocarboxylic acid transporters), member 11	29	0.93
chr10_75835778_75835936	0.21	Gstt2	glutathione S-transferase, theta 2	976	0.36
chr1_85199424_85199611	0.21	AC123856.1	nuclear antigen Sp100 (Sp100) pseudogene	96	0.49
chr2_158179056_158179229	0.21	1700060C20Rik	RIKEN cDNA 1700060C20 gene	12866	0.14
chr19_44997151_44997302	0.21	Sema4g	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G	5090	0.11
chr17_87474571_87474777	0.21	Gm30938	predicted gene, 30938	932	0.44
chr1_86479051_86479408	0.21	Rpl30-ps6	ribosomal protein L30, pseudogene 6	5570	0.15
chr5_121917596_121917747	0.21	Cux2	cut-like homeobox 2	937	0.54
chr16_34745072_34745237	0.20	Mylk	myosin, light polypeptide kinase	56	0.98
chr12_8774307_8774470	0.20	Sdc1	syndecan 1	2585	0.25
chr7_25705726_25706061	0.20	Ccdc97	coiled-coil domain containing 97	10213	0.09
chr8_70659044_70659249	0.20	Pgpep1	pyroglutamyl-peptidase I	234	0.83
chr6_52477529_52477702	0.20	1700094M24Rik	RIKEN cDNA 1700094M24 gene	14836	0.16
chr12_84193897_84194204	0.20	Elmsan1	ELM2 and Myb/SANT-like domain containing 1	35	0.95
chr8_111501860_111502048	0.20	Wdr59	WD repeat domain 59	11201	0.17
chr7_99355809_99355967	0.20	Serpinh1	serine (or cysteine) peptidase inhibitor, clade H, member 1	2649	0.21
chr7_15934182_15934342	0.20	Snord23	small nucleolar RNA, C/D box 23	4608	0.11
chr1_85327350_85327504	0.20	Gm2619	predicted gene 2619	142	0.87
chr4_58913611_58913779	0.20	Ecpas	Ecm29 proteasome adaptor and scaffold	946	0.53
chr11_98777139_98777558	0.19	Nr1d1	nuclear receptor subfamily 1, group D, member 1	2015	0.18
chr7_141456726_141456885	0.19	Pnpla2	patatin-like phospholipase domain containing 2	213	0.8
chr18_35814838_35814999	0.19	Ube2d2a	ubiquitin-conjugating enzyme E2D 2A	13611	0.09
chr9_71165149_71165695	0.19	Aqp9	aquaporin 9	200	0.92
chr1_135311434_135311608	0.19	Timm17a	translocase of inner mitochondrial membrane 17a	176	0.92
chr5_63964660_63964830	0.19	Rell1	RELT-like 1	4078	0.19
chr12_111428451_111428628	0.19	Exoc3l4	exocyst complex component 3-like 4	194	0.9
chr8_120248017_120248168	0.19	Gse1	genetic suppressor element 1, coiled-coil protein	19636	0.16
chr3_95439810_95439972	0.19	Arnt	aryl hydrocarbon receptor nuclear translocator	5372	0.1
chr8_22124952_22125137	0.19	Nek5	NIMA (never in mitosis gene a)-related expressed kinase 5	3	0.97
chr13_75943581_75943755	0.19	Rhobtb3	Rho-related BTB domain containing 3	199	0.9
chr9_48618793_48618948	0.19	Nnmt	nicotinamide N-methyltransferase	13717	0.24
chr3_83953926_83954100	0.18	Tmem131l	transmembrane 131 like	10270	0.26
chr13_30336361_30336758	0.18	Agtr1a	angiotensin II receptor, type 1a	115	0.97
chr1_72827270_72827421	0.18	Igfbp2	insulin-like growth factor binding protein 2	2023	0.37
chr19_41346470_41346772	0.18	Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	38475	0.17
chr5_30816231_30816420	0.18	Gm19409	predicted gene, 19409	705	0.47
chr1_58145718_58146241	0.18	Gm24548	predicted gene, 24548	9109	0.19
chr8_46386589_46386784	0.18	Gm45253	predicted gene 45253	798	0.57
chr7_19211436_19211587	0.18	Gpr4	G protein-coupled receptor 4	1027	0.3
chr18_20945707_20945922	0.18	Rnf125	ring finger protein 125	1189	0.52
chr14_103099863_103100150	0.18	Fbxl3	F-box and leucine-rich repeat protein 3	440	0.8
chr12_25416673_25416856	0.18	Gm36723	predicted gene, 36723	22009	0.24
chr11_120694977_120695348	0.18	Aspscr1	alveolar soft part sarcoma chromosome region, candidate 1 (human)	5852	0.07
chr4_108068074_108068398	0.17	Scp2	sterol carrier protein 2, liver	3127	0.18
chr15_79012870_79013120	0.17	Gm10865	predicted gene 10865	1954	0.13
chr7_127805019_127805207	0.17	9430064I24Rik	RIKEN cDNA 9430064I24 gene	2351	0.11
chr11_102051638_102051976	0.17	Cd300lg	CD300 molecule like family member G	10298	0.09
chr3_151424962_151425113	0.17	Adgrl4	adhesion G protein-coupled receptor L4	12850	0.26
chr14_61861512_61861706	0.17	Gm47952	predicted gene, 47952	59767	0.12
chr1_191906223_191906394	0.17	Slc30a1	solute carrier family 30 (zinc transporter), member 1	459	0.69
chr1_36556661_36556829	0.17	Sema4c	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C	781	0.34
chr6_88820995_88821174	0.17	Mgll	monoglyceride lipase	2046	0.19
chr19_5663348_5663511	0.17	Sipa1	signal-induced proliferation associated gene 1	191	0.84
chr11_106580051_106580208	0.17	Tex2	testis expressed gene 2	471	0.82
chr8_119417331_119417482	0.17	Osgin1	oxidative stress induced growth inhibitor 1	16718	0.14
chr15_84714847_84715041	0.17	Arhgap8	Rho GTPase activating protein 8	5108	0.18
chr9_94538161_94538340	0.17	Dipk2a	divergent protein kinase domain 2A	169	0.96
chr9_37613490_37613650	0.17	Spa17	sperm autoantigenic protein 17	0	0.52
chr9_107657905_107658551	0.17	Slc38a3	solute carrier family 38, member 3	967	0.31
chr3_90537214_90537374	0.17	S100a16	S100 calcium binding protein A16	21	0.93
chr18_20058884_20059060	0.17	Dsc2	desmocollin 2	506	0.84
chr1_191254917_191255072	0.17	Gm37074	predicted gene, 37074	5570	0.14
chr1_155050256_155050434	0.17	Gm29282	predicted gene 29282	6834	0.17
chr15_25940308_25940999	0.17	Retreg1	reticulophagy regulator 1	49	0.98
chrX_12072855_12073006	0.17	Bcor	BCL6 interacting corepressor	7623	0.27
chr4_134995142_134995297	0.17	Syf2	SYF2 homolog, RNA splicing factor (S. cerevisiae)	64209	0.09
chr12_84052558_84052962	0.17	Acot3	acyl-CoA thioesterase 3	336	0.69
chr3_57344020_57344185	0.16	Gm5276	predicted gene 5276	18286	0.19
chr2_167375199_167375534	0.16	B4galt5	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5	26183	0.15
chr11_95827586_95827744	0.16	Phospho1	phosphatase, orphan 1	3098	0.14
chr11_113008652_113008818	0.16	2610035D17Rik	RIKEN cDNA 2610035D17 gene	164342	0.03
chr8_125337571_125337768	0.16	Gm16237	predicted gene 16237	110346	0.06
chr8_111776845_111777015	0.16	Bcar1	breast cancer anti-estrogen resistance 1	33121	0.14
chr15_99716487_99716652	0.16	Gpd1	glycerol-3-phosphate dehydrogenase 1 (soluble)	946	0.3
chr3_85821987_85822152	0.16	Fam160a1	family with sequence similarity 160, member A1	4778	0.2
chr4_32520450_32520651	0.16	Bach2	BTB and CNC homology, basic leucine zipper transcription factor 2	19045	0.19
chr11_119045218_119045965	0.16	Cbx8	chromobox 8	4622	0.17
chr2_30692293_30692476	0.16	Gm14486	predicted gene 14486	14373	0.14
chr4_123412152_123412346	0.16	Macf1	microtubule-actin crosslinking factor 1	21	0.97
chr10_4107762_4107973	0.16	Gm25515	predicted gene, 25515	3554	0.27
chr4_106988955_106989270	0.16	Ssbp3	single-stranded DNA binding protein 3	22686	0.15
chr11_97800088_97800264	0.16	Lasp1	LIM and SH3 protein 1	5	0.94
chr5_125308383_125308534	0.16	Scarb1	scavenger receptor class B, member 1	3916	0.18
chr10_118699777_118699944	0.16	Gm33337	predicted gene, 33337	15866	0.18
chr15_83009671_83009841	0.16	Nfam1	Nfat activating molecule with ITAM motif 1	13327	0.13
chr2_26578415_26578758	0.16	Egfl7	EGF-like domain 7	1428	0.23
chr9_70318576_70318770	0.16	Mir5626	microRNA 5626	87080	0.07
chr15_59717023_59717209	0.16	Gm20150	predicted gene, 20150	45003	0.15
chr1_172312301_172312452	0.16	Igsf8	immunoglobulin superfamily, member 8	9	0.96
chr12_102470243_102470394	0.16	Golga5	golgi autoantigen, golgin subfamily a, 5	1126	0.47
chr10_20669582_20669754	0.15	Gm17230	predicted gene 17230	44033	0.15
chr10_61313715_61314040	0.15	Rpl27a-ps1	ribosomal protein L27A, pseudogene 1	4047	0.16
chr7_45782387_45782600	0.15	Lmtk3	lemur tyrosine kinase 3	1245	0.21
chr4_124709066_124709229	0.15	Sf3a3	splicing factor 3a, subunit 3	5629	0.09
chr2_24335745_24336056	0.15	Il1rn	interleukin 1 receptor antagonist	953	0.46
chr10_80244946_80245115	0.15	Pwwp3a	PWWP domain containing 3A, DNA repair factor	2418	0.12
chr12_108275649_108275819	0.15	Ccdc85c	coiled-coil domain containing 85C	309	0.89
chr4_133556563_133556731	0.15	Gm23158	predicted gene, 23158	2302	0.15
chr11_97435186_97435350	0.15	Arhgap23	Rho GTPase activating protein 23	1017	0.5
chr9_32400631_32400981	0.15	Kcnj1	potassium inwardly-rectifying channel, subfamily J, member 1	6821	0.18
chr16_35310487_35310877	0.15	Gm49706	predicted gene, 49706	12384	0.15
chrX_13245137_13245293	0.15	2010308F09Rik	RIKEN cDNA 2010308F09 gene	2521	0.17
chr7_25776793_25776952	0.15	Axl	AXL receptor tyrosine kinase	2194	0.16
chr19_29142167_29142403	0.15	Mir101b	microRNA 101b	7006	0.15

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ep300

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0046149	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1	0.4	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205)
0.1	0.3	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.1	0.3	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.1	0.3	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.1	0.2	GO:0060128	corticotropin hormone secreting cell differentiation(GO:0060128)
0.1	0.2	GO:0071462	cellular response to water stimulus(GO:0071462)
0.1	0.1	GO:0045163	clustering of voltage-gated potassium channels(GO:0045163)
0.0	0.1	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.2	GO:0035864	response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.0	0.2	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0021553	olfactory nerve development(GO:0021553)
0.0	0.1	GO:0032788	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.1	GO:0010482	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.4	GO:0034244	negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0	0.1	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.0	0.2	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:2000860	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0	0.1	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:1901552	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.1	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.1	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.0	0.1	GO:1902534	single-organism membrane invagination(GO:1902534)
0.0	0.1	GO:0060279	positive regulation of ovulation(GO:0060279)
0.0	0.1	GO:0070574	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.2	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.1	GO:2000974	negative regulation of pro-B cell differentiation(GO:2000974)
0.0	0.2	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.0	0.2	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.0	0.4	GO:0001553	luteinization(GO:0001553)
0.0	0.1	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.1	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.3	GO:0051601	exocyst localization(GO:0051601)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0040031	snRNA modification(GO:0040031)
0.0	0.1	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0	0.1	GO:0060913	cardiac cell fate determination(GO:0060913)
0.0	0.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.1	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.0	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.1	GO:0090290	positive regulation of osteoclast proliferation(GO:0090290)
0.0	0.1	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.0	GO:0036016	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.2	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0035356	cellular triglyceride homeostasis(GO:0035356)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.2	GO:0015727	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0	0.1	GO:0009212	dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.0	0.1	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.0	0.1	GO:0000189	MAPK import into nucleus(GO:0000189)
0.0	0.1	GO:0032287	peripheral nervous system myelin maintenance(GO:0032287)
0.0	0.1	GO:0006116	NADH oxidation(GO:0006116)
0.0	0.1	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	0.1	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.1	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.1	GO:0010603	regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.0	0.1	GO:0072144	glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.0	0.1	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0	0.1	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.1	GO:0072674	multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.0	GO:0061144	alveolar secondary septum development(GO:0061144)
0.0	0.0	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.1	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.0	GO:1901321	positive regulation of heart induction(GO:1901321)
0.0	0.0	GO:0052151	induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139)
0.0	0.1	GO:0021637	trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637)
0.0	0.3	GO:0043153	entrainment of circadian clock by photoperiod(GO:0043153)
0.0	0.2	GO:0007097	nuclear migration(GO:0007097)
0.0	0.0	GO:0090403	oxidative stress-induced premature senescence(GO:0090403)
0.0	0.1	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0	0.0	GO:0061643	chemorepulsion of axon(GO:0061643)
0.0	0.2	GO:0072673	lamellipodium morphogenesis(GO:0072673)
0.0	0.0	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.0	GO:2000909	regulation of cholesterol import(GO:0060620) regulation of sterol import(GO:2000909)
0.0	0.0	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.0	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.0	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.0	GO:2000054	regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000053) negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.0	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.0	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.0	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0	0.0	GO:1904177	regulation of adipose tissue development(GO:1904177)
0.0	0.0	GO:1904431	positive regulation of t-circle formation(GO:1904431)
0.0	0.0	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.0	0.1	GO:0031339	negative regulation of vesicle fusion(GO:0031339)
0.0	0.0	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.0	GO:2000591	cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0	0.1	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.0	GO:0046122	purine deoxyribonucleoside metabolic process(GO:0046122)
0.0	0.0	GO:0021856	cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) facioacoustic ganglion development(GO:1903375)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0	0.0	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.0	0.0	GO:0010745	negative regulation of macrophage derived foam cell differentiation(GO:0010745)
0.0	0.1	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.1	GO:0097062	dendritic spine maintenance(GO:0097062)
0.0	0.1	GO:0007614	short-term memory(GO:0007614)
0.0	0.0	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.0	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.0	GO:0060584	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.0	0.0	GO:0018992	germ-line sex determination(GO:0018992)
0.0	0.1	GO:0045603	positive regulation of endothelial cell differentiation(GO:0045603)
0.0	0.1	GO:0016139	glycoside catabolic process(GO:0016139)
0.0	0.0	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.0	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.2	GO:0009303	rRNA transcription(GO:0009303)
0.0	0.1	GO:0046697	decidualization(GO:0046697)
0.0	0.0	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.0	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.0	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
0.0	0.1	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0097454	Schwann cell microvillus(GO:0097454)
0.1	0.4	GO:0032021	NELF complex(GO:0032021)
0.1	0.2	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.1	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0070522	ERCC4-ERCC1 complex(GO:0070522)
0.0	0.2	GO:0008091	spectrin(GO:0008091)
0.0	0.2	GO:0005744	mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0097452	GAIT complex(GO:0097452)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.2	GO:0001527	microfibril(GO:0001527)
0.0	0.2	GO:0072546	ER membrane protein complex(GO:0072546)
0.0	0.2	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:0005608	laminin-3 complex(GO:0005608)
0.0	0.1	GO:0044611	nuclear pore inner ring(GO:0044611)
0.0	0.5	GO:0051233	spindle midzone(GO:0051233)
0.0	0.3	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.0	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0031983	vesicle lumen(GO:0031983)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0000322	storage vacuole(GO:0000322)
0.0	0.0	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.0	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.1	GO:0097422	tubular endosome(GO:0097422)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.0	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.0	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.0	GO:0045251	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0	0.1	GO:0061700	GATOR2 complex(GO:0061700)
0.0	0.1	GO:0005662	DNA replication factor A complex(GO:0005662)
0.0	0.1	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1	0.2	GO:0031711	bradykinin receptor binding(GO:0031711)
0.1	0.2	GO:0015205	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.1	0.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.3	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.2	GO:0005105	type 1 fibroblast growth factor receptor binding(GO:0005105)
0.0	0.2	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.1	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.1	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.2	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.1	GO:1990226	histone methyltransferase binding(GO:1990226)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.1	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.2	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.2	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.0	0.1	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.2	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0004854	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.0	0.0	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.0	GO:1990188	euchromatin binding(GO:1990188)
0.0	0.2	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.1	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.0	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	0.0	GO:0004676	3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.5	GO:0070888	E-box binding(GO:0070888)
0.0	0.1	GO:0016889	endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.0	0.1	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0005005	transmembrane-ephrin receptor activity(GO:0005005)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0005250	A-type (transient outward) potassium channel activity(GO:0005250)
0.0	0.1	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.1	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.0	0.0	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0	0.1	GO:0070411	I-SMAD binding(GO:0070411)
0.0	0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.0	GO:0031708	endothelin B receptor binding(GO:0031708)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.0	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.0	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.1	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.4	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.5	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.1	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.1	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	REACTOME SCFSKP2 MEDIATED DEGRADATION OF P27 P21	Genes involved in SCF(Skp2)-mediated degradation of p27/p21
0.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.2	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.2	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.2	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.2	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation