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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Ets2

Z-value: 1.56

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Transcription factors associated with Ets2

Gene Symbol	Gene ID	Gene Info
Ets2 Ensembl NCBI MGI UniProt	ENSMUSG00000022895.8	Ets2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Ets2	chr16_95700323_95700474	1677	0.411202	0.87	2.4e-02	Click!
Ets2	chr16_95674781_95674947	27211	0.189461	-0.79	6.3e-02	Click!
Ets2	chr16_95682151_95682417	19791	0.204719	0.78	6.8e-02	Click!
Ets2	chr16_95702849_95703157	503	0.821559	-0.78	6.9e-02	Click!
Ets2	chr16_95729140_95729334	11503	0.179276	0.76	8.2e-02	Click!

Activity of the Ets2 motif across conditions

Conditions sorted by the z-value of the Ets2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_98767399_98767584	1.76	Nr1d1	nuclear receptor subfamily 1, group D, member 1	2935	0.14
chr3_103378119_103378272	0.86	Gm25009	predicted gene, 25009	14738	0.15
chr2_164942950_164943143	0.79	Mmp9	matrix metallopeptidase 9	2266	0.19
chr19_49421746_49421913	0.75	Gm50444	predicted gene, 50444	132189	0.06
chr14_50981405_50981569	0.72	Gm8518	predicted gene 8518	2551	0.12
chr17_88341719_88341880	0.69	Gm22542	predicted gene, 22542	683	0.69
chr9_69028339_69028490	0.67	Rora	RAR-related orphan receptor alpha	167127	0.04
chr11_88897701_88897852	0.66	Gm23507	predicted gene, 23507	7345	0.13
chr14_7977646_7977810	0.66	Dnase1l3	deoxyribonuclease 1-like 3	506	0.78
chr5_76063621_76063793	0.66	Gm6051	predicted gene 6051	2944	0.23
chr17_36867279_36867493	0.65	Trim15	tripartite motif-containing 15	176	0.87
chr3_55828967_55829118	0.64	4933417G07Rik	RIKEN cDNA 4933417G07 gene	18063	0.18
chr1_119495139_119495303	0.63	Gm29454	predicted gene 29454	4256	0.15
chr18_79032313_79032478	0.62	Setbp1	SET binding protein 1	76996	0.12
chr15_57921642_57921803	0.61	Tbc1d31	TBC1 domain family, member 31	5709	0.21
chr10_12278450_12278601	0.61	Gm48723	predicted gene, 48723	46136	0.14
chr12_110381296_110381622	0.59	Gm47195	predicted gene, 47195	56074	0.08
chr15_28106057_28106225	0.57	Gm31458	predicted gene, 31458	12311	0.17
chr3_145834049_145834216	0.56	Ddah1	dimethylarginine dimethylaminohydrolase 1	23653	0.18
chr11_78267972_78268123	0.56	2610507B11Rik	RIKEN cDNA 2610507B11 gene	1914	0.15
chr4_11084820_11085206	0.55	Ndufaf6	NADH:ubiquinone oxidoreductase complex assembly factor 6	8808	0.15
chr2_60922422_60922578	0.52	Rbms1	RNA binding motif, single stranded interacting protein 1	33470	0.19
chr1_151597907_151598058	0.52	Fam129a	family with sequence similarity 129, member A	26486	0.15
chr2_125263901_125264052	0.51	A530010F05Rik	RIKEN cDNA A530010F05 gene	10588	0.16
chr4_138440154_138440340	0.51	Mul1	mitochondrial ubiquitin ligase activator of NFKB 1	5524	0.14
chr11_84062884_84063069	0.51	Dusp14	dual specificity phosphatase 14	4104	0.2
chr4_127263896_127264076	0.50	Smim12	small integral membrane protein 12	20202	0.12
chr14_79157797_79157989	0.49	Gm49015	predicted gene, 49015	6504	0.16
chr10_62506271_62506458	0.49	Srgn	serglycin	1391	0.34
chr18_38190654_38190820	0.48	Pcdh1	protocadherin 1	12426	0.13
chr19_11977402_11977711	0.48	Osbp	oxysterol binding protein	11615	0.09
chr19_42610535_42610705	0.47	Loxl4	lysyl oxidase-like 4	2089	0.31
chr1_23279889_23280199	0.47	Mir30a	microRNA 30a	7775	0.12
chr9_74328886_74329063	0.46	Gm24141	predicted gene, 24141	33636	0.17
chr7_132735250_132735442	0.46	Fam53b	family with sequence similarity 53, member B	41570	0.13
chr19_55491305_55491575	0.45	Vti1a	vesicle transport through interaction with t-SNAREs 1A	110426	0.07
chr10_85354450_85354601	0.45	Gm25281	predicted gene, 25281	20624	0.16
chr18_83740581_83740741	0.44	Gm50419	predicted gene, 50419	86945	0.08
chr11_16737408_16737579	0.44	Gm25698	predicted gene, 25698	4782	0.22
chr3_146846305_146846456	0.44	Ttll7	tubulin tyrosine ligase-like family, member 7	5987	0.18
chr16_95449403_95449694	0.44	Erg	ETS transcription factor	9697	0.27
chr1_39710733_39710905	0.43	Rfx8	regulatory factor X 8	10178	0.19
chr11_6478757_6478908	0.43	Purb	purine rich element binding protein B	2915	0.11
chr5_117361300_117361465	0.43	Wsb2	WD repeat and SOCS box-containing 2	360	0.77
chr14_63133716_63133871	0.43	Ctsb	cathepsin B	1725	0.28
chr14_22269831_22270192	0.43	Lrmda	leucine rich melanocyte differentiation associated	40154	0.2
chr11_103223555_103223709	0.43	Map3k14	mitogen-activated protein kinase kinase kinase 14	1785	0.22
chr4_105257759_105257936	0.43	Plpp3	phospholipid phosphatase 3	100500	0.08
chr1_38109860_38110024	0.42	Rev1	REV1, DNA directed polymerase	18359	0.15
chr7_71704948_71705119	0.42	Gm44688	predicted gene 44688	1043	0.49
chr3_127355382_127355546	0.42	Gm42969	predicted gene 42969	38242	0.11
chr7_80013937_80014119	0.42	Zfp710	zinc finger protein 710	10786	0.12
chr9_54844002_54844168	0.42	Rab7-ps1	RAB7, member RAS oncogene family, pseudogene 1	18803	0.15
chr1_186584026_186584190	0.41	A730004F24Rik	RIKEN cDNA A730004F24 gene	25427	0.19
chr17_8128409_8128574	0.41	Rnaset2a	ribonuclease T2A	19294	0.13
chr6_88584043_88584194	0.40	Kbtbd12	kelch repeat and BTB (POZ) domain containing 12	6541	0.19
chr17_6998212_6998376	0.40	Rnaset2b	ribonuclease T2B	7638	0.13
chr11_4261437_4261588	0.40	Lif	leukemia inhibitory factor	3955	0.13
chr6_116004145_116004296	0.40	Plxnd1	plexin D1	9215	0.16
chr13_111984044_111984208	0.39	Gm15322	predicted gene 15322	7340	0.2
chr8_105504683_105504849	0.39	Gm8838	predicted gene 8838	1360	0.25
chr16_84972074_84972233	0.39	Gm10791	predicted gene 10791	61	0.97
chr2_167831188_167831379	0.38	1200007C13Rik	RIKEN cDNA 1200007C13 gene	2363	0.25
chr15_97590730_97591033	0.38	Gm49506	predicted gene, 49506	32591	0.19
chr11_121686812_121686981	0.38	B3gntl1	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1	13743	0.18
chrY_90828861_90829019	0.37	Gm21742	predicted gene, 21742	8473	0.19
chr9_71606651_71607004	0.37	Gm6018	predicted gene 6018	6687	0.19
chr3_95312699_95312852	0.37	Cers2	ceramide synthase 2	2016	0.14
chr16_32130242_32130457	0.37	Nrros	negative regulator of reactive oxygen species	17532	0.1
chr5_105698740_105698909	0.37	Lrrc8d	leucine rich repeat containing 8D	1145	0.57
chr6_72473587_72473785	0.37	Mat2a	methionine adenosyltransferase II, alpha	34128	0.09
chr11_83224315_83224478	0.36	Gm11427	predicted gene 11427	58	0.73
chr8_88983561_88983712	0.36	Mir8110	microRNA 8110	41099	0.17
chr2_50824872_50825029	0.36	Gm13498	predicted gene 13498	84734	0.1
chr6_72663055_72663233	0.36	Tcf7l1	transcription factor 7 like 1 (T cell specific, HMG box)	8260	0.1
chr4_104840212_104840384	0.35	C8a	complement component 8, alpha polypeptide	16225	0.18
chr8_84068735_84068886	0.35	C330011M18Rik	RIKEN cDNA C330011M18 gene	1523	0.16
chr8_122313304_122313653	0.35	Zfpm1	zinc finger protein, multitype 1	6158	0.15
chr2_152359606_152359999	0.35	Gm14165	predicted gene 14165	6187	0.1
chr12_5213695_5213866	0.35	Gm48532	predicted gene, 48532	22184	0.23
chr5_139329080_139329231	0.35	Adap1	ArfGAP with dual PH domains 1	3533	0.16
chr5_25100632_25101023	0.35	2900005J15Rik	RIKEN cDNA 2900005J15 gene	156	0.53
chr7_126494300_126494471	0.35	Atxn2l	ataxin 2-like	1009	0.34
chr15_27925949_27926114	0.35	Trio	triple functional domain (PTPRF interacting)	6760	0.24
chr19_5274259_5274410	0.35	Pacs1	phosphofurin acidic cluster sorting protein 1	1215	0.24
chr4_133169582_133169763	0.35	Wasf2	WAS protein family, member 2	6329	0.15
chr11_117878325_117878508	0.35	Tha1	threonine aldolase 1	4935	0.11
chr2_31825447_31825664	0.35	Qrfp	pyroglutamylated RFamide peptide	14975	0.13
chr11_3289571_3289722	0.35	Patz1	POZ (BTB) and AT hook containing zinc finger 1	347	0.8
chr9_124423659_124423821	0.34	Ppp2r3d	protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta	157	0.94
chr16_84834907_84835088	0.34	Atp5j	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F	8	0.54
chr11_79223575_79223745	0.34	Gm11200	predicted gene 11200	10864	0.17
chr11_80067662_80067813	0.34	Crlf3	cytokine receptor-like factor 3	9838	0.16
chr15_53724232_53724383	0.33	1700015H07Rik	RIKEN cDNA 1700015H07 gene	102652	0.07
chr10_121521092_121521243	0.33	Gm35696	predicted gene, 35696	10769	0.11
chr7_145102326_145102499	0.33	Gm45181	predicted gene 45181	60584	0.12
chr5_134572591_134572794	0.33	Mir7228	microRNA 7228	616	0.56
chr11_16844158_16844466	0.33	Egfros	epidermal growth factor receptor, opposite strand	13610	0.2
chr3_137860459_137860760	0.33	Gm43403	predicted gene 43403	3574	0.12
chr9_109118225_109118412	0.33	Plxnb1	plexin B1	11524	0.1
chr10_78135134_78135285	0.33	Gm47922	predicted gene, 47922	2888	0.18
chr15_77343141_77343292	0.33	Gm49436	predicted gene, 49436	23483	0.1
chr17_48039561_48039744	0.33	1700122O11Rik	RIKEN cDNA 1700122O11 gene	1359	0.33
chr15_73153357_73153508	0.33	Ago2	argonaute RISC catalytic subunit 2	24415	0.17
chr11_106382531_106382850	0.33	Icam2	intercellular adhesion molecule 2	91	0.96
chr10_72778559_72778735	0.33	Gm47094	predicted gene, 47094	60716	0.14
chr10_75048271_75048422	0.32	Rab36	RAB36, member RAS oncogene family	10123	0.15
chr2_104817028_104817755	0.32	Qser1	glutamine and serine rich 1	631	0.64
chr7_25776793_25776952	0.32	Axl	AXL receptor tyrosine kinase	2194	0.16
chr8_120041013_120041184	0.32	Gm15684	predicted gene 15684	4189	0.17
chr16_30066871_30067038	0.32	Hes1	hes family bHLH transcription factor 1	616	0.68
chr11_115641190_115641341	0.32	Slc25a19	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19	12970	0.09
chr15_99333031_99333200	0.32	Fmnl3	formin-like 3	2612	0.15
chr15_64043505_64043715	0.32	Fam49b	family with sequence similarity 49, member B	16720	0.16
chr4_41760316_41760485	0.31	Il11ra1	interleukin 11 receptor, alpha chain 1	54	0.94
chr1_191154426_191154595	0.31	Fam71a	family with sequence similarity 71, member A	10307	0.13
chr13_5592555_5592743	0.31	Gm35330	predicted gene, 35330	21521	0.26
chr6_142708472_142708687	0.31	Abcc9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	6264	0.22
chr13_119723468_119723673	0.31	Nim1k	NIM1 serine/threonine protein kinase	14824	0.11
chr16_49801576_49801764	0.31	Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	1137	0.53
chr7_101360514_101360680	0.31	Arap1	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1	665	0.54
chr13_5845761_5845936	0.31	1700016G22Rik	RIKEN cDNA 1700016G22 gene	11713	0.16
chr2_179583110_179583261	0.31	Gm14300	predicted gene 14300	30382	0.23
chr18_46253564_46253715	0.31	Pggt1b	protein geranylgeranyltransferase type I, beta subunit	4734	0.19
chr5_32745803_32745961	0.31	Pisd	phosphatidylserine decarboxylase	430	0.74
chr16_44029399_44029560	0.31	Gramd1c	GRAM domain containing 1C	1534	0.37
chr12_69516624_69516775	0.31	5830428M24Rik	RIKEN cDNA 5830428M24 gene	41149	0.1
chr4_136090324_136090475	0.30	Gm13009	predicted gene 13009	15427	0.12
chr10_107361652_107361839	0.30	Gm38117	predicted gene, 38117	75614	0.09
chr19_34199620_34199771	0.30	Stambpl1	STAM binding protein like 1	6873	0.18
chr1_165617212_165617387	0.30	Mpzl1	myelin protein zero-like 1	3320	0.14
chr11_16895683_16895855	0.30	Egfr	epidermal growth factor receptor	9416	0.2
chr8_126757967_126758167	0.30	Gm45805	predicted gene 45805	267	0.94
chr3_35318331_35318524	0.30	Gm25442	predicted gene, 25442	7187	0.25
chr9_16115179_16115336	0.30	Fat3	FAT atypical cadherin 3	108507	0.07
chr10_93285572_93285740	0.30	Elk3	ELK3, member of ETS oncogene family	25155	0.14
chr16_11006083_11006392	0.30	Gm24961	predicted gene, 24961	11851	0.1
chr14_63957868_63958033	0.29	Sox7	SRY (sex determining region Y)-box 7	14277	0.16
chr17_58480733_58480887	0.29	Gm49848	predicted gene, 49848	18485	0.25
chr5_53214446_53214609	0.29	Sel1l3	sel-1 suppressor of lin-12-like 3 (C. elegans)	600	0.76
chr17_9512595_9512746	0.29	Gm49807	predicted gene, 49807	37021	0.18
chr11_78600166_78600339	0.29	Gm11196	predicted gene 11196	14697	0.1
chr11_16756467_16757088	0.29	Egfr	epidermal growth factor receptor	4547	0.23
chr14_73838973_73839138	0.29	Gm16409	predicted gene 16409	41765	0.13
chr3_142745096_142745348	0.29	Gm15540	predicted gene 15540	541	0.67
chr12_73715979_73716146	0.29	Prkch	protein kinase C, eta	67141	0.1
chr9_45247764_45247948	0.28	Gm20612	predicted gene 20612	13199	0.1
chr9_118611265_118611450	0.28	Itga9	integrin alpha 9	4667	0.19
chr18_21242831_21243130	0.28	Garem1	GRB2 associated regulator of MAPK1 subtype 1	57143	0.11
chr6_117431300_117431501	0.28	Gm4640	predicted gene 4640	7783	0.22
chr9_79605873_79606044	0.28	Col12a1	collagen, type XII, alpha 1	7012	0.21
chr9_110326292_110326443	0.28	Gm42638	predicted gene 42638	4197	0.13
chr19_37248362_37248513	0.28	Gm25268	predicted gene, 25268	14953	0.13
chr9_23011584_23011737	0.28	Bmper	BMP-binding endothelial regulator	211416	0.02
chr10_21946855_21947006	0.28	Sgk1	serum/glucocorticoid regulated kinase 1	18460	0.17
chr13_18800559_18800710	0.28	Vps41	VPS41 HOPS complex subunit	20791	0.24
chr17_28029449_28029600	0.28	Anks1	ankyrin repeat and SAM domain containing 1	11251	0.12
chr5_124074959_124075110	0.28	Abcb9	ATP-binding cassette, sub-family B (MDR/TAP), member 9	4097	0.12
chr17_43242727_43242878	0.28	Adgrf1	adhesion G protein-coupled receptor F1	27527	0.22
chr9_32901306_32901512	0.28	Gm27162	predicted gene 27162	27557	0.18
chr14_65113058_65113209	0.28	Extl3	exostosin-like glycosyltransferase 3	15027	0.18
chr8_83773624_83773779	0.28	Gm45778	predicted gene 45778	24197	0.11
chr8_119424899_119425070	0.27	Osgin1	oxidative stress induced growth inhibitor 1	9140	0.15
chr8_117321338_117321500	0.27	Cmip	c-Maf inducing protein	27751	0.21
chr15_10981382_10981708	0.27	Amacr	alpha-methylacyl-CoA racemase	211	0.92
chr1_85526452_85526618	0.27	AC147806.2	predicted 7592	67	0.59
chr2_69116662_69116813	0.27	Nostrin	nitric oxide synthase trafficker	19063	0.19
chr4_117124519_117125009	0.27	Btbd19	BTB (POZ) domain containing 19	402	0.61
chr1_93634572_93634756	0.27	Gm28536	predicted gene 28536	529	0.56
chr2_18944090_18944247	0.27	Pip4k2a	phosphatidylinositol-5-phosphate 4-kinase, type II, alpha	37894	0.17
chr10_61929391_61929572	0.27	Gm5750	predicted gene 5750	30143	0.16
chr16_90677368_90677525	0.27	Gm36169	predicted gene, 36169	446	0.78
chr10_116264669_116264820	0.27	Ptprb	protein tyrosine phosphatase, receptor type, B	10779	0.19
chr11_16844975_16845160	0.27	Egfros	epidermal growth factor receptor, opposite strand	14365	0.2
chr2_28526560_28526711	0.27	Ralgds	ral guanine nucleotide dissociation stimulator	1215	0.31
chr15_77606069_77606360	0.26	Gm36245	predicted gene, 36245	6956	0.11
chr5_35729958_35730139	0.26	Sh3tc1	SH3 domain and tetratricopeptide repeats 1	772	0.61
chr6_142649490_142649655	0.26	5330439B14Rik	RIKEN cDNA 5330439B14 gene	34977	0.15
chr13_111933651_111933850	0.26	Gm9025	predicted gene 9025	49573	0.1
chr15_64345201_64345377	0.26	Asap1	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	4597	0.21
chr10_94565775_94566229	0.26	Tmcc3	transmembrane and coiled coil domains 3	9255	0.17
chr1_150459711_150460052	0.26	Prg4	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	5717	0.2
chr9_29666708_29666884	0.26	Gm15521	predicted gene 15521	74286	0.13
chr1_125489382_125489583	0.26	Gm28706	predicted gene 28706	44915	0.15
chr10_78326387_78326551	0.26	Agpat3	1-acylglycerol-3-phosphate O-acyltransferase 3	5779	0.09
chr12_35021403_35021554	0.25	Snx13	sorting nexin 13	25708	0.16
chr16_33580716_33580902	0.25	Slc12a8	solute carrier family 12 (potassium/chloride transporters), member 8	15753	0.25
chr19_10236152_10236493	0.25	Myrf	myelin regulatory factor	4282	0.13
chr7_49178293_49178474	0.25	Gm37613	predicted gene, 37613	17158	0.18
chr13_111896407_111896568	0.25	Gm9025	predicted gene 9025	12310	0.15
chr16_4512630_4512833	0.25	Srl	sarcalumenin	10332	0.16
chr15_77626960_77627111	0.25	Gm8221	predicted gene 8221	5201	0.11
chr1_85649860_85650030	0.25	Sp100	nuclear antigen Sp100	43	0.91
chr9_32906562_32906941	0.25	Gm27162	predicted gene 27162	22215	0.19
chr6_142346265_142346455	0.25	Pyroxd1	pyridine nucleotide-disulphide oxidoreductase domain 1	576	0.69
chr2_71867523_71867680	0.25	Pdk1	pyruvate dehydrogenase kinase, isoenzyme 1	5623	0.2
chr12_80887036_80887400	0.25	Susd6	sushi domain containing 6	18510	0.13
chr11_57445339_57445531	0.25	Gm12242	predicted gene 12242	3672	0.29
chr10_25434450_25434623	0.25	Epb41l2	erythrocyte membrane protein band 4.1 like 2	1920	0.35
chr13_112116146_112116297	0.25	Gm31104	predicted gene, 31104	21895	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Ets2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.2	0.6	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
0.1	0.2	GO:1904192	cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.1	0.2	GO:0035910	ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1	0.2	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1	0.2	GO:0021553	olfactory nerve development(GO:0021553)
0.1	0.2	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.1	0.2	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.1	0.2	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.1	0.3	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.1	0.2	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.1	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.2	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.2	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0	0.2	GO:0008228	opsonization(GO:0008228)
0.0	0.2	GO:0045402	interleukin-4 biosynthetic process(GO:0042097) regulation of interleukin-4 biosynthetic process(GO:0045402)
0.0	0.1	GO:0042126	nitrate metabolic process(GO:0042126)
0.0	0.2	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.5	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0	0.2	GO:0009211	pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
0.0	0.1	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.0	0.1	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.5	GO:0046697	decidualization(GO:0046697)
0.0	0.1	GO:1902996	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.2	GO:0031915	positive regulation of synaptic plasticity(GO:0031915)
0.0	0.1	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.0	0.1	GO:0030578	PML body organization(GO:0030578)
0.0	0.1	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0	0.3	GO:0006183	GTP biosynthetic process(GO:0006183)
0.0	0.1	GO:0044805	lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) late nucleophagy(GO:0044805)
0.0	0.1	GO:2000111	positive regulation of macrophage apoptotic process(GO:2000111)
0.0	0.1	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.3	GO:0022027	interkinetic nuclear migration(GO:0022027)
0.0	0.1	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.1	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0046122	purine deoxyribonucleoside metabolic process(GO:0046122)
0.0	0.1	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.1	GO:1900451	positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0	0.1	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.2	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.1	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
0.0	0.1	GO:2001168	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0	0.2	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.1	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.1	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:1900106	hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.0	0.1	GO:1903679	regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0	0.1	GO:0071462	cellular response to water stimulus(GO:0071462)
0.0	0.1	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.1	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	0.0	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.2	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	0.1	GO:0015822	ornithine transport(GO:0015822) L-ornithine transmembrane transport(GO:1903352)
0.0	0.3	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
0.0	0.0	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.0	0.0	GO:0036166	phenotypic switching(GO:0036166)
0.0	0.2	GO:0086036	regulation of cardiac muscle cell membrane potential(GO:0086036)
0.0	0.1	GO:0006990	positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response(GO:0006990)
0.0	0.0	GO:0060154	cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0	0.1	GO:0032802	low-density lipoprotein particle receptor catabolic process(GO:0032802) regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.0	0.2	GO:0075522	IRES-dependent viral translational initiation(GO:0075522)
0.0	0.1	GO:0071639	positive regulation of monocyte chemotactic protein-1 production(GO:0071639)
0.0	0.0	GO:0046881	positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.1	GO:0002669	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.0	0.0	GO:0035087	siRNA loading onto RISC involved in RNA interference(GO:0035087)
0.0	0.1	GO:0072711	response to hydroxyurea(GO:0072710) cellular response to hydroxyurea(GO:0072711)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.1	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0	0.1	GO:1904139	microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0	0.0	GO:1905005	regulation of epithelial to mesenchymal transition involved in endocardial cushion formation(GO:1905005)
0.0	0.1	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.2	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.0	0.1	GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520)
0.0	0.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.1	GO:1902548	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
0.0	0.0	GO:0090271	positive regulation of fibroblast growth factor production(GO:0090271)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:1902993	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0	0.0	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.1	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.1	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.1	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.1	GO:2000667	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0072008	glomerular mesangial cell differentiation(GO:0072008) glomerular mesangial cell development(GO:0072144)
0.0	0.1	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.0	GO:2000611	positive regulation of thyroid hormone generation(GO:2000611)
0.0	0.1	GO:0030213	hyaluronan biosynthetic process(GO:0030213)
0.0	0.1	GO:0046726	positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0	0.1	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.2	GO:0010310	regulation of hydrogen peroxide metabolic process(GO:0010310)
0.0	0.2	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0046719	regulation by virus of viral protein levels in host cell(GO:0046719)
0.0	0.1	GO:0090135	actin filament branching(GO:0090135)
0.0	0.1	GO:0030576	Cajal body organization(GO:0030576)
0.0	0.1	GO:0010288	response to lead ion(GO:0010288)
0.0	0.2	GO:0032610	interleukin-1 alpha production(GO:0032610)
0.0	0.0	GO:0052422	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0	0.0	GO:0060825	fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.0	0.0	GO:0061031	endodermal digestive tract morphogenesis(GO:0061031)
0.0	0.1	GO:0060011	Sertoli cell proliferation(GO:0060011)
0.0	0.1	GO:0045759	negative regulation of action potential(GO:0045759)
0.0	0.0	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0	0.0	GO:0000737	DNA catabolic process, endonucleolytic(GO:0000737)
0.0	0.0	GO:0032278	positive regulation of gonadotropin secretion(GO:0032278)
0.0	0.1	GO:0097500	receptor localization to nonmotile primary cilium(GO:0097500)
0.0	0.3	GO:0042036	negative regulation of cytokine biosynthetic process(GO:0042036)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.0	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.0	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.0	GO:2000002	negative regulation of DNA damage checkpoint(GO:2000002)
0.0	0.2	GO:2000811	negative regulation of anoikis(GO:2000811)
0.0	0.3	GO:0015986	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	0.1	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:0071276	cellular response to cadmium ion(GO:0071276)
0.0	0.0	GO:0002434	immune complex clearance(GO:0002434)
0.0	0.0	GO:0010847	regulation of chromatin assembly(GO:0010847)
0.0	0.0	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.2	GO:0071218	cellular response to misfolded protein(GO:0071218)
0.0	0.0	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.2	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.0	GO:0032439	endosome localization(GO:0032439)
0.0	0.0	GO:0021943	formation of radial glial scaffolds(GO:0021943)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:1902093	positive regulation of sperm motility(GO:1902093)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.0	GO:0061625	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.0	GO:0060956	endocardial cell differentiation(GO:0060956)
0.0	0.0	GO:0031448	regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448)
0.0	0.1	GO:0021535	cell migration in hindbrain(GO:0021535)
0.0	0.0	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.0	0.1	GO:0001921	positive regulation of receptor recycling(GO:0001921)
0.0	0.0	GO:1903999	negative regulation of eating behavior(GO:1903999)
0.0	0.0	GO:0000087	mitotic M phase(GO:0000087)
0.0	0.1	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.0	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0	0.1	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.0	0.1	GO:0048597	post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0	0.0	GO:0036258	multivesicular body assembly(GO:0036258)
0.0	0.0	GO:1900157	regulation of bone mineralization involved in bone maturation(GO:1900157)
0.0	0.1	GO:0071139	resolution of recombination intermediates(GO:0071139)
0.0	0.0	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.0	GO:0014724	regulation of twitch skeletal muscle contraction(GO:0014724)
0.0	0.0	GO:0003096	renal sodium ion transport(GO:0003096)
0.0	0.1	GO:0048194	Golgi vesicle budding(GO:0048194)
0.0	0.1	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.2	GO:0030502	negative regulation of bone mineralization(GO:0030502)
0.0	0.1	GO:0048549	positive regulation of pinocytosis(GO:0048549)
0.0	0.1	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.1	GO:0010701	positive regulation of norepinephrine secretion(GO:0010701)
0.0	0.0	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.0	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0	0.1	GO:0060591	chondroblast differentiation(GO:0060591)
0.0	0.1	GO:0040016	embryonic cleavage(GO:0040016)
0.0	0.0	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.0	0.1	GO:0036315	cellular response to sterol(GO:0036315)
0.0	0.0	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.0	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0	0.0	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.0	0.0	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0	0.1	GO:0036120	cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0	0.1	GO:0051444	negative regulation of ubiquitin-protein transferase activity(GO:0051444)
0.0	0.0	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.0	GO:0021615	glossopharyngeal nerve morphogenesis(GO:0021615)
0.0	0.1	GO:0045835	negative regulation of meiotic nuclear division(GO:0045835)
0.0	0.1	GO:0048133	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0	0.0	GO:0030575	nuclear body organization(GO:0030575)
0.0	0.0	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.2	GO:0035855	megakaryocyte development(GO:0035855)
0.0	0.0	GO:0032349	positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.0	0.1	GO:0045908	negative regulation of vasodilation(GO:0045908)
0.0	0.2	GO:0048488	synaptic vesicle endocytosis(GO:0048488)
0.0	0.3	GO:0010107	potassium ion import(GO:0010107)
0.0	0.0	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.0	GO:0033625	positive regulation of integrin activation(GO:0033625)
0.0	0.1	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.0	GO:0042167	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.0	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.0	GO:0010626	negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.1	GO:1900746	regulation of vascular endothelial growth factor signaling pathway(GO:1900746) regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902547)
0.0	0.0	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.0	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.1	GO:0046643	regulation of gamma-delta T cell differentiation(GO:0045586) regulation of gamma-delta T cell activation(GO:0046643)
0.0	0.1	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0	0.1	GO:0034498	early endosome to Golgi transport(GO:0034498)
0.0	0.1	GO:0060136	embryonic process involved in female pregnancy(GO:0060136)
0.0	0.1	GO:0051447	negative regulation of meiotic cell cycle(GO:0051447)
0.0	0.0	GO:0072061	inner medullary collecting duct development(GO:0072061)
0.0	0.1	GO:0048304	positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.0	0.2	GO:0050650	chondroitin sulfate proteoglycan biosynthetic process(GO:0050650)
0.0	0.1	GO:0022615	protein to membrane docking(GO:0022615)
0.0	0.0	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.4	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0	0.0	GO:0046909	intermembrane transport(GO:0046909)
0.0	0.1	GO:0002523	leukocyte migration involved in inflammatory response(GO:0002523)
0.0	0.0	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.0	0.0	GO:0071332	cellular response to fructose stimulus(GO:0071332)
0.0	0.1	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591)
0.0	0.0	GO:0000350	generation of catalytic spliceosome for second transesterification step(GO:0000350)
0.0	0.0	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.0	0.0	GO:1903232	melanosome assembly(GO:1903232)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.2	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.1	0.2	GO:0044611	nuclear pore inner ring(GO:0044611)
0.0	0.4	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.2	GO:1990696	USH2 complex(GO:1990696)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.0	0.2	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.4	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.1	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0071203	WASH complex(GO:0071203)
0.0	0.1	GO:0071797	LUBAC complex(GO:0071797)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.2	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.1	GO:0061574	ASAP complex(GO:0061574)
0.0	0.1	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.1	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.1	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.0	0.1	GO:0031465	Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0	0.3	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.0	0.0	GO:0035061	interchromatin granule(GO:0035061)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.2	GO:0031512	motile primary cilium(GO:0031512)
0.0	0.1	GO:0030128	clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0045261	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.0	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.1	GO:0030896	checkpoint clamp complex(GO:0030896)
0.0	0.0	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.0	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.0	GO:0034457	Mpp10 complex(GO:0034457)
0.0	0.1	GO:0098799	outer mitochondrial membrane protein complex(GO:0098799)
0.0	0.1	GO:0036038	MKS complex(GO:0036038)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0097422	tubular endosome(GO:0097422)
0.0	0.0	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	0.2	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.1	0.2	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.2	GO:0015119	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.4	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.4	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.2	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.2	GO:0042731	PH domain binding(GO:0042731)
0.0	0.2	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	0.3	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.2	GO:0004673	protein histidine kinase activity(GO:0004673)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.2	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0	0.1	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
0.0	0.3	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0030620	U2 snRNA binding(GO:0030620)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.2	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.0	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.0	0.1	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.0	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.2	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.1	GO:0048763	calcium-induced calcium release activity(GO:0048763)
0.0	0.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.1	GO:0015189	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.3	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.1	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.0	0.2	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.2	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.1	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.2	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.0	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0019808	polyamine binding(GO:0019808)
0.0	0.1	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.0	0.1	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.2	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.1	GO:0015272	ATP-activated inward rectifier potassium channel activity(GO:0015272)
0.0	0.0	GO:0051377	mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.0	0.0	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.1	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.0	0.1	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.0	GO:0001030	RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0	0.0	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.1	GO:0017099	very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0	0.1	GO:0010181	FMN binding(GO:0010181)
0.0	0.3	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	0.2	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)
0.0	0.0	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.2	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.0	GO:0010858	calcium-dependent protein kinase regulator activity(GO:0010858)
0.0	0.0	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0035473	lipase binding(GO:0035473)
0.0	0.1	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.1	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.0	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0004143	diacylglycerol kinase activity(GO:0004143)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.0	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.1	GO:0001609	G-protein coupled adenosine receptor activity(GO:0001609)
0.0	0.1	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.0	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.1	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0008865	fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
0.0	0.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.0	GO:0070137	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.1	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.0	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.0	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.0	GO:0070991	medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.0	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.0	GO:0015205	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.0	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0030547	receptor inhibitor activity(GO:0030547)
0.0	0.1	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.0	GO:0004488	methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.0	0.0	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.3	GO:0051721	protein phosphatase 2A binding(GO:0051721)
0.0	0.0	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
0.0	0.1	GO:0048256	flap endonuclease activity(GO:0048256)
0.0	0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.7	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
1.0	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.5	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.8	PID AR PATHWAY	Coregulation of Androgen receptor activity
0.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.3	PID ALK1 PATHWAY	ALK1 signaling events
0.0	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.5	PID IL4 2PATHWAY	IL4-mediated signaling events
0.4	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.3	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.8	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.4	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.1	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.0	0.0	REACTOME DOWNSTREAM TCR SIGNALING	Genes involved in Downstream TCR signaling
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.2	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.1	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.3	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.2	REACTOME SIGNALING BY FGFR1 MUTANTS	Genes involved in Signaling by FGFR1 mutants
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.5	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.3	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0	0.0	REACTOME APC C CDC20 MEDIATED DEGRADATION OF MITOTIC PROTEINS	Genes involved in APC/C:Cdc20 mediated degradation of mitotic proteins
0.0	0.4	REACTOME INWARDLY RECTIFYING K CHANNELS	Genes involved in Inwardly rectifying K+ channels
0.0	0.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.0	REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE	Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
0.0	0.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.1	REACTOME SEMA3A PAK DEPENDENT AXON REPULSION	Genes involved in Sema3A PAK dependent Axon repulsion
0.0	0.1	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway