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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Etv6

Z-value: 1.60

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Transcription factors associated with Etv6

Gene Symbol	Gene ID	Gene Info
Etv6 Ensembl NCBI MGI UniProt	ENSMUSG00000030199.10	Etv6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Etv6	chr6_134039206_134039407	3337	0.250610	-0.97	1.2e-03	Click!
Etv6	chr6_134271340_134271530	23870	0.149971	0.91	1.2e-02	Click!
Etv6	chr6_134036525_134036733	660	0.723229	-0.89	1.8e-02	Click!
Etv6	chr6_134036923_134037340	1162	0.507613	-0.87	2.6e-02	Click!
Etv6	chr6_134045191_134045355	9304	0.190962	0.84	3.7e-02	Click!

Activity of the Etv6 motif across conditions

Conditions sorted by the z-value of the Etv6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_156523955_156524106	0.84	Csnk2a3	casein kinase 2 alpha 3	18	0.97
chr14_20319722_20320198	0.75	Nudt13	nudix (nucleoside diphosphate linked moiety X)-type motif 13	8531	0.12
chr9_45677619_45677770	0.71	Dscaml1	DS cell adhesion molecule like 1	4857	0.22
chr5_116024413_116024572	0.68	Prkab1	protein kinase, AMP-activated, beta 1 non-catalytic subunit	16	0.96
chr14_20315223_20315409	0.67	Nudt13	nudix (nucleoside diphosphate linked moiety X)-type motif 13	3887	0.15
chrX_60547467_60547618	0.67	Gm715	predicted gene 715	477	0.75
chr1_171418992_171419158	0.65	Tstd1	thiosulfate sulfurtransferase (rhodanese)-like domain containing 1	42	0.93
chr7_4792782_4792944	0.62	Rpl28	ribosomal protein L28	11	0.93
chr10_58255342_58255504	0.57	Gcc2	GRIP and coiled-coil domain containing 2	74	0.96
chr4_136886108_136886460	0.57	C1qb	complement component 1, q subcomponent, beta polypeptide	97	0.96
chr8_105297519_105297695	0.53	E2f4	E2F transcription factor 4	56	0.9
chr5_33658354_33658511	0.53	Tmem129	transmembrane protein 129	16	0.6
chr11_85492360_85492531	0.53	Bcas3	breast carcinoma amplified sequence 3	123	0.95
chr10_116264669_116264820	0.52	Ptprb	protein tyrosine phosphatase, receptor type, B	10779	0.19
chr7_48917526_48917677	0.52	Gm45282	predicted gene 45282	7539	0.14
chr10_75834373_75834559	0.50	Gstt2	glutathione S-transferase, theta 2	3	0.95
chr2_27540118_27540305	0.49	Gm13421	predicted gene 13421	215	0.57
chr11_88204256_88204424	0.49	Mrps23	mitochondrial ribosomal protein S23	48	0.97
chr2_3727636_3727853	0.48	Fam107b	family with sequence similarity 107, member B	14266	0.16
chr11_5485683_5486034	0.47	Gm11962	predicted gene 11962	9588	0.14
chr9_107563062_107563244	0.46	Tusc2	tumor suppressor 2, mitochondrial calcium regulator	102	0.87
chr16_89830199_89830569	0.45	Tiam1	T cell lymphoma invasion and metastasis 1	7491	0.3
chr5_125361058_125361209	0.45	Gm40323	predicted gene, 40323	42	0.96
chr11_69554847_69555031	0.45	Efnb3	ephrin B3	5266	0.08
chr2_94010737_94010899	0.44	Alkbh3	alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase	11	0.97
chr6_120822682_120822842	0.44	Atp6v1e1	ATPase, H+ transporting, lysosomal V1 subunit E1	31	0.97
chr3_109255070_109255263	0.44	Gm13865	predicted gene 13865	62299	0.11
chr13_21362713_21362885	0.43	Zscan12	zinc finger and SCAN domain containing 12	21	0.94
chr5_105112436_105112587	0.43	Gbp9	guanylate-binding protein 9	2234	0.28
chr8_11009560_11009740	0.42	Irs2	insulin receptor substrate 2	1192	0.34
chr17_20945145_20945356	0.42	Ppp2r1a	protein phosphatase 2, regulatory subunit A, alpha	61	0.54
chr1_133610283_133610442	0.41	Snrpe	small nuclear ribonucleoprotein E	71	0.96
chr5_3490465_3490637	0.41	Gm42435	predicted gene 42435	9521	0.13
chr1_180226517_180226708	0.41	Psen2	presenilin 2	2956	0.19
chr17_27839932_27840089	0.41	Snrpc	U1 small nuclear ribonucleoprotein C	74	0.95
chr2_58516954_58517105	0.40	Acvr1	activin A receptor, type 1	757	0.71
chr11_86757488_86757692	0.40	Cltc	clathrin, heavy polypeptide (Hc)	25	0.98
chr10_128805402_128805563	0.40	Dnajc14	DnaJ heat shock protein family (Hsp40) member C14	72	0.91
chr15_79670588_79670885	0.39	Tomm22	translocase of outer mitochondrial membrane 22	125	0.91
chr7_105744339_105744512	0.38	Taf10	TATA-box binding protein associated factor 10	64	0.94
chr10_13008300_13008462	0.38	Sf3b5	splicing factor 3b, subunit 5	3038	0.25
chr8_94183485_94183637	0.38	Gm39228	predicted gene, 39228	272	0.83
chr7_99483674_99483841	0.38	Rps3	ribosomal protein S3	19	0.93
chr10_59629065_59629266	0.37	Mcu	mitochondrial calcium uniporter	12473	0.19
chr9_65032284_65032455	0.37	Dpp8	dipeptidylpeptidase 8	45	0.97
chr10_10457121_10457304	0.37	Gm48326	predicted gene, 48326	8322	0.2
chr11_70764308_70764498	0.36	Zfp3	zinc finger protein 3	194	0.85
chr11_5955636_5955797	0.36	Ykt6	YKT6 v-SNARE homolog (S. cerevisiae)	23	0.97
chr2_31052576_31052733	0.36	Fnbp1	formin binding protein 1	2790	0.24
chr1_97770025_97770211	0.36	Gin1	gypsy retrotransposon integrase 1	54	0.8
chr1_74289444_74289611	0.36	Gm37503	predicted gene, 37503	1667	0.15
chr4_95354053_95354288	0.36	Gm29064	predicted gene 29064	48620	0.15
chr14_51884664_51884952	0.36	Mettl17	methyltransferase like 17	34	0.94
chr9_20581222_20581545	0.35	Zfp846	zinc finger protein 846	58	0.96
chr11_3452291_3452451	0.35	8430429K09Rik	RIKEN cDNA 8430429K09 gene	6	0.49
chr5_145201795_145201971	0.35	Zkscan14	zinc finger with KRAB and SCAN domains 14	15	0.95
chr16_3872258_3872624	0.35	Zfp597	zinc finger protein 597	45	0.51
chr9_110887920_110888088	0.35	Als2cl	ALS2 C-terminal like	9	0.95
chr19_42631725_42631876	0.35	Loxl4	lysyl oxidase-like 4	18987	0.18
chr2_94406648_94406807	0.34	Ttc17	tetratricopeptide repeat domain 17	38	0.91
chr1_167308570_167308761	0.34	Tmco1	transmembrane and coiled-coil domains 1	5	0.96
chr13_52041479_52041668	0.33	Gm37872	predicted gene, 37872	19646	0.19
chr18_67448711_67448888	0.33	Afg3l2	AFG3-like AAA ATPase 2	308	0.86
chr11_78245899_78246053	0.32	Supt6	SPT6, histone chaperone and transcription elongation factor	11	0.73
chr9_46272980_46273140	0.32	Zpr1	ZPR1 zinc finger	4	0.94
chr2_32535355_32535730	0.32	Fam102a	family with sequence similarity 102, member A	183	0.89
chr19_45006439_45006606	0.32	Twnk	twinkle mtDNA helicase	36	0.53
chr8_77610687_77610852	0.31	Tmem184c	transmembrane protein 184C	71	0.52
chr14_122104924_122105095	0.31	A330035P11Rik	RIKEN cDNA A330035P11 gene	1944	0.21
chr15_8109190_8109363	0.31	Nup155	nucleoporin 155	3	0.98
chr19_28963790_28963966	0.30	4430402I18Rik	RIKEN cDNA 4430402I18 gene	30	0.54
chr8_33885650_33885854	0.30	Gm26978	predicted gene, 26978	5	0.97
chr11_77793325_77793488	0.30	Gm10277	predicted gene 10277	5659	0.16
chr17_33948663_33948832	0.30	B3galt4	UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4	2741	0.06
chr7_99694503_99694673	0.30	Gm34280	predicted gene, 34280	291	0.76
chr9_20521327_20521505	0.30	Zfp266	zinc finger protein 266	1	0.96
chr19_53332014_53332179	0.29	Mxi1	MAX interactor 1, dimerization protein	1688	0.28
chr9_20952862_20953022	0.29	Dnmt1	DNA methyltransferase (cytosine-5) 1	37	0.95
chr17_36271362_36271517	0.29	Trim39	tripartite motif-containing 39	56	0.91
chr2_27626035_27626261	0.29	Rxra	retinoid X receptor alpha	50292	0.12
chr9_124424078_124424238	0.28	Ppp2r3d	protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta	4	0.97
chr15_34443209_34443373	0.28	Rpl30	ribosomal protein L30	32	0.8
chr3_95217667_95217848	0.28	Gabpb2	GA repeat binding protein, beta 2	3	0.79
chr13_64398164_64398509	0.28	Ctsl	cathepsin L	27446	0.09
chr10_14705498_14705660	0.28	Nmbr	neuromedin B receptor	12	0.5
chr4_125066548_125066718	0.27	Snip1	Smad nuclear interacting protein 1	39	0.93
chr5_146770278_146770441	0.27	Usp12	ubiquitin specific peptidase 12	11903	0.15
chr4_124802426_124802586	0.27	Mtf1	metal response element binding transcription factor 1	43	0.95
chr4_133941503_133941734	0.27	Hmgn2	high mobility group nucleosomal binding domain 2	25625	0.11
chr4_48279558_48279880	0.27	Invs	inversin	41	0.66
chr17_26113206_26113368	0.27	Tmem8	transmembrane protein 8	12	0.94
chr1_182520133_182520312	0.27	Capn2	calpain 2	2614	0.21
chr12_108792186_108792364	0.27	Gm34220	predicted gene, 34220	468	0.53
chr3_95871479_95871654	0.27	C920021L13Rik	RIKEN cDNA C920021L13 gene	35	0.49
chr6_125009567_125009728	0.27	Zfp384	zinc finger protein 384	22	0.94
chr4_81766890_81767041	0.27	Gm11412	predicted gene 11412	23819	0.23
chr15_64060280_64060431	0.26	Fam49b	family with sequence similarity 49, member B	12	0.98
chr2_121473990_121474147	0.26	Mfap1b	microfibrillar-associated protein 1B	1	0.94
chr2_29935294_29935462	0.26	Gle1	GLE1 RNA export mediator (yeast)	48	0.95
chr15_66865965_66866140	0.26	Ccn4	cellular communication network factor 4	25268	0.16
chr1_192770564_192770748	0.26	Hhat	hedgehog acyltransferase	336	0.87
chr11_95146239_95146409	0.26	Dlx4	distal-less homeobox 4	61	0.95
chr17_35241635_35241803	0.25	Ddx39b	DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B	27	0.88
chr16_31948445_31948606	0.25	Ncbp2	nuclear cap binding protein subunit 2	12	0.49
chr11_77078417_77078807	0.25	Nsrp1	nuclear speckle regulatory protein 1	177	0.75
chr6_35539812_35539979	0.25	Mtpn	myotrophin	7	0.98
chr13_46669359_46669525	0.25	Fam8a1	family with sequence similarity 8, member A1	80	0.97
chr17_46621404_46621583	0.25	Ptk7	PTK7 protein tyrosine kinase 7	8011	0.1
chr4_120975511_120975682	0.25	Smap2	small ArfGAP 2	112	0.94
chr11_94653678_94653838	0.25	Mrpl27	mitochondrial ribosomal protein L27	9	0.56
chr17_31305538_31305732	0.25	Slc37a1	solute carrier family 37 (glycerol-3-phosphate transporter), member 1	92	0.96
chr17_8310765_8311153	0.25	4930506C21Rik	RIKEN cDNA 4930506C21 gene	93	0.41
chr14_26669821_26669989	0.25	Pde12	phosphodiesterase 12	22	0.52
chr11_83298893_83299082	0.24	Pex12	peroxisomal biogenesis factor 12	10	0.5
chr16_16526849_16527032	0.24	Fgd4	FYVE, RhoGEF and PH domain containing 4	471	0.82
chr7_79228544_79228706	0.24	Gm31510	predicted gene, 31510	44186	0.1
chr1_167353970_167354146	0.24	Aldh9a1	aldehyde dehydrogenase 9, subfamily A1	3746	0.15
chr17_49458493_49458669	0.24	Mocs1	molybdenum cofactor synthesis 1	6297	0.24
chr6_126107373_126107694	0.24	Ntf3	neurotrophin 3	57427	0.15
chr12_55155236_55155394	0.24	Srp54b	signal recognition particle 54B	55	0.85
chr7_45434250_45434440	0.24	Ruvbl2	RuvB-like protein 2	68	0.83
chr10_81606036_81606372	0.23	BC025920	cDNA sequence BC025920	66	0.93
chr15_98506392_98506556	0.23	Olfr278-ps1	olfactory receptor 278, pseudogene 1	7069	0.07
chr3_108256959_108257142	0.23	1700010K24Rik	RIKEN cDNA 1700010K24 gene	65	0.56
chr5_9087032_9087225	0.23	Tmem243	transmembrane protein 243, mitochondrial	13540	0.16
chr2_91412402_91412624	0.23	Gm22071	predicted gene, 22071	5377	0.18
chr7_45923080_45923254	0.23	Ccdc114	coiled-coil domain containing 114	905	0.25
chr2_145934675_145934834	0.23	Cfap61	cilia and flagella associated protein 61	30	0.5
chr12_55080388_55080552	0.23	Srp54a	signal recognition particle 54A	56	0.82
chr5_105789979_105790426	0.23	Rps15a-ps5	ribosomal protein S15A, pseudogene 5	7511	0.17
chr8_120324733_120324902	0.22	Gse1	genetic suppressor element 1, coiled-coil protein	96361	0.06
chrX_168673452_168673623	0.22	Msl3	MSL complex subunit 3	361	0.91
chr8_84856734_84857027	0.22	Farsa	phenylalanyl-tRNA synthetase, alpha subunit	109	0.9
chr7_28796738_28796906	0.22	Rinl	Ras and Rab interactor-like	116	0.91
chr3_101524513_101524690	0.22	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	52959	0.11
chr1_36244254_36244418	0.22	Uggt1	UDP-glucose glycoprotein glucosyltransferase 1	31	0.97
chr9_78489041_78489208	0.22	Eef1a1	eukaryotic translation elongation factor 1 alpha 1	27	0.96
chr6_52160159_52160321	0.22	Hotairm1	Hoxa transcript antisense RNA, myeloid-specific 1	1716	0.12
chr8_10857974_10858150	0.22	Gm32540	predicted gene, 32540	8124	0.12
chr11_46039470_46039639	0.22	Gm12165	predicted gene 12165	3114	0.18
chr19_5366591_5366746	0.21	Banf1	BAF nuclear assembly factor 1	62	0.49
chr2_75978121_75978296	0.21	Ttc30a2	tetratricopeptide repeat domain 30A2	38	0.97
chr2_48814064_48814223	0.21	Acvr2a	activin receptor IIA	34	0.98
chr11_48800219_48800381	0.21	Rack1	receptor for activated C kinase 1	32	0.88
chr17_26663048_26663210	0.20	Atp6v0e	ATPase, H+ transporting, lysosomal V0 subunit E	102	0.96
chr19_8770923_8771084	0.20	Tmem223	transmembrane protein 223	7	0.87
chr9_41105205_41105372	0.20	Gm48611	predicted gene, 48611	6793	0.17
chr8_69808918_69809151	0.20	Gmip	Gem-interacting protein	344	0.77
chr16_91740939_91741112	0.20	Itsn1	intersectin 1 (SH3 domain protein 1A)	10791	0.14
chrX_7841056_7841418	0.20	Otud5	OTU domain containing 5	127	0.91
chr17_33915764_33916103	0.20	Zbtb22	zinc finger and BTB domain containing 22	29	0.48
chrX_12376263_12376437	0.20	Gm14635	predicted gene 14635	21354	0.24
chr10_80129893_80130054	0.20	Stk11	serine/threonine kinase 11	3291	0.11
chr5_122318215_122318386	0.20	Gm15842	predicted gene 15842	15878	0.1
chr11_78436121_78436295	0.20	Gm11195	predicted gene 11195	7899	0.09
chr2_19004905_19005068	0.20	4930426L09Rik	RIKEN cDNA 4930426L09 gene	6643	0.22
chr1_118321721_118321879	0.19	Nifk	nucleolar protein interacting with the FHA domain of MKI67	39	0.97
chr9_20951552_20951703	0.19	Dnmt1	DNA methyltransferase (cytosine-5) 1	978	0.34
chr1_171113920_171114112	0.19	Cfap126	cilia and flagella associated protein 126	27	0.95
chr17_26916833_26917013	0.19	Kifc5b	kinesin family member C5B	168	0.87
chr13_17993285_17993442	0.19	Yae1d1	Yae1 domain containing 1	14	0.93
chr9_43210448_43210605	0.19	Pou2f3	POU domain, class 2, transcription factor 3	157	0.94
chr9_37348340_37348499	0.18	Ccdc15	coiled-coil domain containing 15	13	0.96
chr7_126695761_126695919	0.18	Slx1b	SLX1 structure-specific endonuclease subunit homolog B (S. cerevisiae)	56	0.57
chr12_25239865_25240032	0.18	Gm19340	predicted gene, 19340	42647	0.13
chr19_46136477_46136807	0.18	Pitx3	paired-like homeodomain transcription factor 3	647	0.58
chr6_124965441_124965599	0.18	Cops7a	COP9 signalosome subunit 7A	8	0.93
chr2_71039832_71040019	0.18	Dcaf17	DDB1 and CUL4 associated factor 17	15403	0.19
chr5_143758154_143758320	0.18	D130017N08Rik	RIKEN cDNA D130017N08 gene	117	0.96
chr2_84714853_84715028	0.18	Zdhhc5	zinc finger, DHHC domain containing 5	96	0.92
chr6_48708145_48708369	0.18	Gimap6	GTPase, IMAP family member 6	32	0.93
chr3_107850765_107850942	0.18	Gm36211	predicted gene, 36211	17314	0.08
chr9_49486024_49486190	0.18	Ttc12	tetratricopeptide repeat domain 12	108	0.97
chr10_80320493_80320652	0.18	2310011J03Rik	RIKEN cDNA 2310011J03 gene	35	0.92
chr6_91877905_91878069	0.18	Gm44712	predicted gene 44712	2	0.54
chr11_58330593_58330753	0.17	Sh3bp5l	SH3 binding domain protein 5 like	51	0.81
chr10_22731356_22731520	0.17	Tbpl1	TATA box binding protein-like 1	9	0.72
chr6_92042166_92042321	0.17	Fgd5	FYVE, RhoGEF and PH domain containing 5	25186	0.13
chr13_52024582_52024974	0.17	Gm37872	predicted gene, 37872	2851	0.3
chr18_60848929_60849091	0.17	Tcof1	treacle ribosome biogenesis factor 1	39	0.97
chr2_60878102_60878265	0.17	Rbms1	RNA binding motif, single stranded interacting protein 1	3255	0.35
chr10_80151775_80151933	0.17	Midn	midnolin	616	0.5
chr10_128547738_128547893	0.17	Zc3h10	zinc finger CCCH type containing 10	41	0.91
chr5_100663119_100663274	0.17	Coq2	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	1223	0.4
chr12_7946863_7947014	0.17	Gm48633	predicted gene, 48633	3123	0.25
chr10_67285195_67285355	0.17	Nrbf2	nuclear receptor binding factor 2	30	0.97
chr4_44065513_44065687	0.17	Gne	glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase	1320	0.35
chr2_26493017_26493193	0.16	Notch1	notch 1	10717	0.1
chr13_56588544_56588882	0.16	2010203P06Rik	RIKEN cDNA 2010203P06 gene	6824	0.18
chr1_132362082_132362267	0.16	Tmcc2	transmembrane and coiled-coil domains 2	2774	0.18
chr11_4849530_4849684	0.16	Nf2	neurofibromin 2	71	0.97
chr11_84867701_84867877	0.16	Ggnbp2	gametogenetin binding protein 2	2413	0.18
chr11_73137165_73137468	0.16	Haspin	histone H3 associated protein kinase	978	0.41
chr2_90904641_90904800	0.16	Ndufs3	NADH:ubiquinone oxidoreductase core subunit S3	18	0.49
chr11_16508132_16508289	0.16	Sec61g	SEC61, gamma subunit	44	0.98
chr7_128237495_128237652	0.16	Armc5	armadillo repeat containing 5	216	0.67
chr11_9373284_9373435	0.16	Abca13	ATP-binding cassette, sub-family A (ABC1), member 13	179908	0.03
chrX_107816272_107816433	0.16	2610002M06Rik	RIKEN cDNA 2610002M06 gene	18	0.62
chr16_25052954_25053153	0.16	A230028O05Rik	RIKEN cDNA A230028O05 gene	6586	0.32
chr3_94886891_94887048	0.16	Psmb4	proteasome (prosome, macropain) subunit, beta type 4	8	0.96

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Etv6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.1	0.4	GO:0035553	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1	0.4	GO:0052173	response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
0.1	0.4	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.1	0.3	GO:0090309	positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.1	0.3	GO:0030576	Cajal body organization(GO:0030576)
0.1	0.3	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
0.1	0.3	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.1	0.4	GO:2001270	regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001270)
0.1	0.2	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
0.1	0.4	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.1	0.3	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1	0.2	GO:0090579	transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
0.1	0.4	GO:0015074	DNA integration(GO:0015074)
0.1	0.4	GO:0045040	protein import into mitochondrial outer membrane(GO:0045040)
0.1	0.2	GO:0070601	centromeric sister chromatid cohesion(GO:0070601)
0.1	0.2	GO:2000002	negative regulation of DNA damage checkpoint(GO:2000002)
0.1	0.2	GO:0042998	positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.1	0.3	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.1	0.1	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.1	0.4	GO:0070365	hepatocyte differentiation(GO:0070365)
0.1	0.1	GO:0035262	gonad morphogenesis(GO:0035262)
0.1	0.2	GO:0046881	positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.2	GO:0030035	microspike assembly(GO:0030035)
0.0	0.2	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.5	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.2	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.2	GO:0060971	embryonic heart tube left/right pattern formation(GO:0060971)
0.0	0.1	GO:0046075	dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.0	0.2	GO:1903977	positive regulation of glial cell migration(GO:1903977)
0.0	0.3	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0	0.5	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.1	GO:1904431	positive regulation of t-circle formation(GO:1904431)
0.0	0.1	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.1	GO:2000015	regulation of determination of dorsal identity(GO:2000015)
0.0	0.1	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0	0.1	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.0	0.1	GO:1903232	melanosome assembly(GO:1903232)
0.0	0.2	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0	0.1	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.0	0.1	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.0	0.4	GO:0051016	barbed-end actin filament capping(GO:0051016)
0.0	0.2	GO:0000338	protein deneddylation(GO:0000338)
0.0	0.1	GO:0098789	pre-mRNA cleavage required for polyadenylation(GO:0098789)
0.0	0.1	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0	0.1	GO:0043201	response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0	0.1	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.7	GO:0015988	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0	0.1	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0	0.2	GO:0030953	astral microtubule organization(GO:0030953)
0.0	0.1	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.1	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.0	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.0	0.1	GO:0033132	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.1	GO:0061635	regulation of protein complex stability(GO:0061635)
0.0	0.1	GO:0009298	GDP-mannose biosynthetic process(GO:0009298)
0.0	0.2	GO:2000786	positive regulation of autophagosome assembly(GO:2000786)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0006056	cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.2	GO:0042790	transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0	0.2	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.2	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.0	GO:0007403	glial cell fate determination(GO:0007403)
0.0	0.3	GO:0046686	response to cadmium ion(GO:0046686)
0.0	0.6	GO:0006958	complement activation, classical pathway(GO:0006958)
0.0	0.1	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.0	0.1	GO:0052490	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.0	0.1	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.4	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.0	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.0	0.0	GO:0009750	response to fructose(GO:0009750) cellular response to fructose stimulus(GO:0071332)
0.0	0.3	GO:0030970	retrograde protein transport, ER to cytosol(GO:0030970)
0.0	0.1	GO:0000447	endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000447)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:0070900	mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
0.0	0.0	GO:0042117	monocyte activation(GO:0042117)
0.0	0.1	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	0.1	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.0	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
0.0	0.2	GO:0044406	adhesion of symbiont to host(GO:0044406)
0.0	0.0	GO:0070340	detection of bacterial lipopeptide(GO:0070340)
0.0	0.2	GO:0043984	histone H4-K16 acetylation(GO:0043984)
0.0	0.1	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.4	GO:0006904	vesicle docking involved in exocytosis(GO:0006904)
0.0	0.0	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.2	GO:0002862	negative regulation of inflammatory response to antigenic stimulus(GO:0002862)
0.0	0.0	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.0	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:0051131	chaperone-mediated protein complex assembly(GO:0051131)
0.0	0.0	GO:0072321	chaperone-mediated protein transport(GO:0072321)
0.0	0.1	GO:0016558	protein import into peroxisome matrix(GO:0016558)
0.0	0.2	GO:1903427	negative regulation of reactive oxygen species biosynthetic process(GO:1903427)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.3	GO:0007032	endosome organization(GO:0007032)
0.0	0.1	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0031523	Myb complex(GO:0031523)
0.1	0.4	GO:0097441	basilar dendrite(GO:0097441)
0.1	0.3	GO:0044611	nuclear pore inner ring(GO:0044611)
0.1	0.3	GO:0097504	Gemini of coiled bodies(GO:0097504)
0.1	0.3	GO:0048179	activin receptor complex(GO:0048179)
0.1	0.3	GO:0005745	m-AAA complex(GO:0005745)
0.1	0.4	GO:0000125	PCAF complex(GO:0000125)
0.1	0.3	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.1	0.2	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	0.3	GO:0097255	R2TP complex(GO:0097255)
0.1	0.2	GO:0097543	ciliary inversin compartment(GO:0097543)
0.1	0.4	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1	0.5	GO:0005687	U4 snRNP(GO:0005687)
0.1	0.2	GO:0072487	MSL complex(GO:0072487)
0.0	0.3	GO:0000243	commitment complex(GO:0000243)
0.0	0.3	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.5	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.4	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.5	GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain(GO:0033178)
0.0	0.2	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.7	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.2	GO:0035032	phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0	0.1	GO:0071797	LUBAC complex(GO:0071797)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.3	GO:0001527	microfibril(GO:0001527)
0.0	0.2	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	0.1	GO:1990246	uniplex complex(GO:1990246)
0.0	0.2	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.2	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.1	GO:0048476	Holliday junction resolvase complex(GO:0048476)
0.0	0.3	GO:0005721	pericentric heterochromatin(GO:0005721)
0.0	0.1	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.0	GO:0033647	host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0	0.2	GO:0060091	kinocilium(GO:0060091)
0.0	0.1	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.1	GO:0031502	dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0	0.8	GO:0015935	small ribosomal subunit(GO:0015935)
0.0	0.2	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	0.1	GO:0071014	post-mRNA release spliceosomal complex(GO:0071014)
0.0	0.1	GO:1990745	EARP complex(GO:1990745)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0005845	mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518)
0.0	0.9	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
0.0	0.1	GO:0030478	actin cap(GO:0030478)
0.0	0.1	GO:0034709	methylosome(GO:0034709)
0.0	0.0	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.2	GO:0005839	proteasome core complex(GO:0005839)
0.0	0.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.2	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.1	0.3	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.1	0.3	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1	0.4	GO:0032051	clathrin light chain binding(GO:0032051)
0.1	0.4	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.1	0.5	GO:0017002	activin-activated receptor activity(GO:0017002)
0.1	0.7	GO:1990446	U1 snRNP binding(GO:1990446)
0.1	0.2	GO:0015119	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1	0.2	GO:0030621	U4 snRNA binding(GO:0030621)
0.1	0.5	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1	0.3	GO:0004826	phenylalanine-tRNA ligase activity(GO:0004826)
0.1	0.2	GO:0016309	1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.0	0.2	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.0	0.1	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.1	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
0.0	0.2	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.5	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.4	GO:0015266	protein channel activity(GO:0015266)
0.0	0.7	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	0.1	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.1	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	1.0	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.5	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.5	GO:1990841	promoter-specific chromatin binding(GO:1990841)
0.0	0.1	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.5	GO:0004602	glutathione peroxidase activity(GO:0004602)
0.0	0.3	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.2	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.5	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0	0.3	GO:0017056	structural constituent of nuclear pore(GO:0017056)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.1	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.2	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.1	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0	0.1	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.0	0.6	GO:0031369	translation initiation factor binding(GO:0031369)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.4	GO:0050780	dopamine receptor binding(GO:0050780)
0.0	0.2	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.1	GO:0052723	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.1	GO:0070728	leucine binding(GO:0070728)
0.0	0.1	GO:0015386	sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0	0.2	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.3	GO:0004298	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0	0.1	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
0.0	0.0	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.4	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.2	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.0	GO:0002046	opsin binding(GO:0002046)
0.0	0.3	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.2	GO:0016922	ligand-dependent nuclear receptor binding(GO:0016922)
0.0	0.1	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.0	0.4	GO:0030331	estrogen receptor binding(GO:0030331)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID NFAT 3PATHWAY	Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0	0.5	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0	0.3	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.4	PID MYC PATHWAY	C-MYC pathway
0.0	0.8	PID LKB1 PATHWAY	LKB1 signaling events
0.0	0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.1	PID EPHB FWD PATHWAY	EPHB forward signaling
0.0	0.2	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.4	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.2	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.2	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	0.1	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.5	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.4	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.4	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.9	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.4	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	1.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.1	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.2	REACTOME DSCAM INTERACTIONS	Genes involved in DSCAM interactions
0.0	0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.3	REACTOME REGULATION OF GLUCOKINASE BY GLUCOKINASE REGULATORY PROTEIN	Genes involved in Regulation of Glucokinase by Glucokinase Regulatory Protein
0.0	0.1	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors