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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Evx2

Z-value: 1.22

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Transcription factors associated with Evx2

Gene Symbol	Gene ID	Gene Info
Evx2 Ensembl NCBI MGI UniProt	ENSMUSG00000001815.9	even-skipped homeobox 2

Activity of the Evx2 motif across conditions

Conditions sorted by the z-value of the Evx2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_125526040_125526191	2.01	Tmem132b	transmembrane protein 132B	5659	0.17
chr19_44400352_44400581	1.43	Scd1	stearoyl-Coenzyme A desaturase 1	6224	0.15
chr8_93164567_93164980	1.17	Ces1d	carboxylesterase 1D	5202	0.15
chr3_129545820_129545971	1.12	Elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	6485	0.17
chr2_18048778_18049088	1.08	Skida1	SKI/DACH domain containing 1	98	0.94
chr2_122251200_122251358	1.06	Sord	sorbitol dehydrogenase	16530	0.1
chr2_58787554_58787770	1.01	Upp2	uridine phosphorylase 2	22337	0.18
chr13_52979672_52979858	0.99	Nfil3	nuclear factor, interleukin 3, regulated	1308	0.43
chr17_89646332_89646522	0.96	Gm50061	predicted gene, 50061	106099	0.08
chrX_140535575_140535726	0.89	Tsc22d3	TSC22 domain family, member 3	7018	0.21
chr5_28982906_28983061	0.76	Rnf32	ring finger protein 32	213009	0.02
chr6_72155996_72156358	0.74	Gm38832	predicted gene, 38832	6672	0.15
chr16_93333790_93334136	0.71	1810053B23Rik	RIKEN cDNA 1810053B23 gene	19226	0.18
chr6_52610697_52610915	0.71	Gm44434	predicted gene, 44434	7561	0.15
chr3_18165162_18165350	0.71	Gm23686	predicted gene, 23686	12369	0.23
chr4_117997840_117998088	0.70	9530034E10Rik	RIKEN cDNA 9530034E10 gene	22928	0.14
chr12_51274477_51274668	0.67	Rps11-ps4	ribosomal protein S11, pseudogene 4	22915	0.22
chr17_81386211_81386362	0.67	Gm50044	predicted gene, 50044	15453	0.24
chr15_3495710_3495861	0.67	Ghr	growth hormone receptor	24141	0.25
chr4_136470355_136470864	0.67	Luzp1	leucine zipper protein 1	759	0.6
chr8_93176743_93176912	0.66	Ces1d	carboxylesterase 1D	1538	0.3
chr15_59002495_59002896	0.63	4930544F09Rik	RIKEN cDNA 4930544F09 gene	18559	0.16
chr10_87932167_87932318	0.61	Tyms-ps	thymidylate synthase, pseudogene	34605	0.14
chr18_60606060_60606525	0.60	Synpo	synaptopodin	3813	0.19
chr19_44392649_44392816	0.59	Scd1	stearoyl-Coenzyme A desaturase 1	13958	0.14
chr13_44437957_44438156	0.59	1700029N11Rik	RIKEN cDNA 1700029N11 gene	1656	0.27
chr7_65902304_65902456	0.59	Pcsk6	proprotein convertase subtilisin/kexin type 6	39948	0.14
chr4_108044596_108044811	0.58	Gm23354	predicted gene, 23354	2903	0.17
chr6_119404440_119404707	0.57	Adipor2	adiponectin receptor 2	12902	0.2
chr4_148590620_148590972	0.56	Srm	spermidine synthase	707	0.49
chr6_82067875_82068026	0.56	Gm15864	predicted gene 15864	15369	0.17
chr14_7834896_7835063	0.54	Flnb	filamin, beta	17022	0.15
chr3_28701950_28702157	0.54	Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	4036	0.21
chr5_144338503_144338654	0.54	Dmrt1i	Dmrt1 interacting ncRNA	19345	0.15
chr4_81502043_81502194	0.54	Gm11765	predicted gene 11765	40386	0.18
chr5_87349083_87349430	0.53	Gm42796	predicted gene 42796	6579	0.11
chr14_62884538_62884723	0.53	n-R5s47	nuclear encoded rRNA 5S 47	14916	0.13
chr1_21246022_21246220	0.52	Gsta3	glutathione S-transferase, alpha 3	5492	0.12
chr3_51255928_51256079	0.52	Elf2	E74-like factor 2	4238	0.15
chr10_87870357_87870520	0.52	Igf1os	insulin-like growth factor 1, opposite strand	7057	0.21
chr7_19508824_19509003	0.51	Trappc6a	trafficking protein particle complex 6A	183	0.76
chr16_87627804_87628113	0.51	Gm22808	predicted gene, 22808	6838	0.21
chr19_44401346_44401497	0.50	Scd1	stearoyl-Coenzyme A desaturase 1	5269	0.16
chr11_30774536_30774692	0.50	Psme4	proteasome (prosome, macropain) activator subunit 4	2293	0.25
chr1_102517589_102517767	0.50	Gm20281	predicted gene, 20281	58756	0.14
chr11_16830427_16830830	0.49	Egfros	epidermal growth factor receptor, opposite strand	74	0.98
chr5_102010214_102010423	0.49	Wdfy3	WD repeat and FYVE domain containing 3	28760	0.16
chr4_19705795_19705946	0.48	Wwp1	WW domain containing E3 ubiquitin protein ligase 1	3123	0.28
chr1_51922891_51923061	0.48	Myo1b	myosin IB	6905	0.14
chr5_108694583_108695258	0.48	Fgfrl1	fibroblast growth factor receptor-like 1	418	0.74
chr18_20654349_20654505	0.48	Gm16090	predicted gene 16090	10833	0.17
chr1_161260852_161261210	0.48	Prdx6	peroxiredoxin 6	9812	0.17
chr8_93190868_93191185	0.47	Gm45909	predicted gene 45909	332	0.84
chr7_142084617_142084768	0.47	Gm25416	predicted gene, 25416	6255	0.09
chr9_109966945_109967106	0.47	Map4	microtubule-associated protein 4	1992	0.21
chr10_59768237_59768395	0.47	Micu1	mitochondrial calcium uptake 1	5903	0.18
chr16_11109338_11109489	0.47	Txndc11	thioredoxin domain containing 11	13324	0.1
chr3_28706532_28706683	0.46	Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	8590	0.17
chr7_102310929_102311109	0.46	Stim1	stromal interaction molecule 1	42692	0.09
chr15_3463620_3463812	0.45	Ghr	growth hormone receptor	7928	0.3
chr6_28460412_28460596	0.45	Gm43264	predicted gene 43264	6477	0.13
chr4_3321136_3321319	0.45	Gm11786	predicted gene 11786	5948	0.22
chr8_90869900_90870054	0.45	Gm45640	predicted gene 45640	6604	0.14
chr4_143168207_143168375	0.44	Gm13039	predicted gene 13039	1688	0.29
chr19_27218754_27218961	0.44	Vldlr	very low density lipoprotein receptor	1399	0.44
chr17_86283565_86284088	0.44	2010106C02Rik	RIKEN cDNA 2010106C02 gene	3352	0.34
chr1_51272730_51272882	0.44	Cavin2	caveolae associated 2	16320	0.19
chr12_73861884_73862127	0.44	Gm15283	predicted gene 15283	7607	0.18
chr15_78413091_78413287	0.43	Mpst	mercaptopyruvate sulfurtransferase	3207	0.12
chr19_37507552_37507703	0.43	Exoc6	exocyst complex component 6	13252	0.16
chr2_58786750_58786901	0.43	Upp2	uridine phosphorylase 2	21500	0.19
chr3_79563335_79563486	0.43	Fnip2	folliculin interacting protein 2	4269	0.14
chr15_59040377_59040733	0.43	Mtss1	MTSS I-BAR domain containing 1	41	0.98
chr13_37854787_37854958	0.43	Rreb1	ras responsive element binding protein 1	3062	0.27
chr1_52434996_52435147	0.43	Gm23460	predicted gene, 23460	9473	0.19
chr4_147433621_147433808	0.42	Gm13161	predicted gene 13161	9757	0.14
chr13_35463284_35463451	0.42	Gm48703	predicted gene, 48703	67984	0.1
chr2_73910165_73910316	0.42	Atp5g3	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit C3 (subunit 9)	219	0.94
chr5_150918259_150918412	0.42	Kl	klotho	34272	0.15
chr4_134151936_134152400	0.42	Cep85	centrosomal protein 85	2315	0.16
chr16_92609058_92609294	0.42	Gm26626	predicted gene, 26626	3638	0.27
chr8_61309660_61309840	0.41	1700001D01Rik	RIKEN cDNA 1700001D01 gene	20878	0.18
chr14_21095037_21095192	0.41	Adk	adenosine kinase	18962	0.21
chr2_52604905_52605378	0.41	Bloc1s2-ps	biogenesis of lysosomal organelles complex-1, subunit 2, pseudogene	14613	0.2
chr11_20206679_20206887	0.41	Rab1a	RAB1A, member RAS oncogene family	5174	0.18
chr9_106231818_106232229	0.40	Alas1	aminolevulinic acid synthase 1	5061	0.11
chr1_39445974_39446266	0.40	Gm37265	predicted gene, 37265	26188	0.13
chr8_3050274_3050432	0.40	Gm44634	predicted gene 44634	5941	0.21
chr15_38105734_38106027	0.39	Gm49312	predicted gene, 49312	26778	0.13
chr15_53297534_53297744	0.39	Ext1	exostosin glycosyltransferase 1	48020	0.18
chr6_72120521_72121047	0.39	4933431G14Rik	RIKEN cDNA 4933431G14 gene	2156	0.2
chr3_14854527_14854724	0.39	Car3	carbonic anhydrase 3	8887	0.18
chr4_108061168_108061369	0.39	Scp2	sterol carrier protein 2, liver	10095	0.13
chr7_127930738_127930911	0.38	Prss8	protease, serine 8 (prostasin)	720	0.39
chr9_15301044_15301207	0.38	4931406C07Rik	RIKEN cDNA 4931406C07 gene	389	0.57
chr5_8668241_8668412	0.38	Gm42684	predicted gene 42684	1194	0.46
chr11_90664516_90664907	0.38	Tom1l1	target of myb1-like 1 (chicken)	1399	0.43
chr4_121078016_121078199	0.37	Zmpste24	zinc metallopeptidase, STE24	369	0.74
chr11_115670523_115670692	0.37	Gm11702	predicted gene 11702	13048	0.1
chr11_115939789_115939955	0.37	Sap30bp	SAP30 binding protein	6198	0.09
chr4_101198122_101198415	0.37	Gm24468	predicted gene, 24468	11504	0.14
chr18_33336650_33336801	0.36	Gm5503	predicted gene 5503	48230	0.16
chr11_22493852_22494015	0.36	Gm12051	predicted gene 12051	10325	0.19
chr3_149182406_149182576	0.36	Gm42647	predicted gene 42647	27780	0.19
chr12_73905148_73905311	0.36	Hif1a	hypoxia inducible factor 1, alpha subunit	2675	0.24
chr15_88854629_88854809	0.36	Pim3	proviral integration site 3	7467	0.13
chr2_34805333_34805900	0.36	Fbxw2	F-box and WD-40 domain protein 2	3047	0.15
chr1_13368915_13369352	0.36	Ncoa2	nuclear receptor coactivator 2	3296	0.16
chr6_70874912_70875301	0.35	Eif2ak3	eukaryotic translation initiation factor 2 alpha kinase 3	3455	0.18
chr15_3109577_3109743	0.35	Gm49222	predicted gene, 49222	5949	0.21
chr15_58983651_58983950	0.35	4930544F09Rik	RIKEN cDNA 4930544F09 gene	336	0.87
chr5_22549698_22549942	0.35	Orc5	origin recognition complex, subunit 5	302	0.68
chr16_70325907_70326108	0.35	Gbe1	glucan (1,4-alpha-), branching enzyme 1	11873	0.25
chr11_75486969_75487306	0.35	Prpf8	pre-mRNA processing factor 8	282	0.79
chr5_92706309_92706705	0.35	Shroom3	shroom family member 3	22882	0.15
chr10_51233946_51234117	0.34	Gm5040	predicted gene 5040	4798	0.28
chr3_95881097_95881422	0.34	Ciart	circadian associated repressor of transcription	13	0.94
chr9_82976267_82976461	0.34	Phip	pleckstrin homology domain interacting protein	848	0.65
chr15_3463467_3463618	0.34	Ghr	growth hormone receptor	8102	0.29
chr3_18164974_18165125	0.34	Gm23686	predicted gene, 23686	12576	0.23
chr9_106788095_106788832	0.34	Rad54l2	RAD54 like 2 (S. cerevisiae)	713	0.62
chr5_146239767_146239953	0.34	Cdk8	cyclin-dependent kinase 8	8475	0.12
chr6_52577244_52577395	0.34	Gm44445	predicted gene, 44445	16767	0.14
chr13_96960473_96960682	0.33	Gm48597	predicted gene, 48597	9663	0.17
chr12_57870893_57871061	0.33	Gm46329	predicted gene, 46329	80234	0.1
chr15_9076174_9076325	0.33	Nadk2	NAD kinase 2, mitochondrial	972	0.61
chr15_58976761_58976951	0.33	Mtss1	MTSS I-BAR domain containing 1	4317	0.18
chr5_99234120_99234297	0.33	Rasgef1b	RasGEF domain family, member 1B	142	0.97
chr13_109652718_109653039	0.33	Pde4d	phosphodiesterase 4D, cAMP specific	20098	0.29
chr3_51277891_51278084	0.33	Elf2	E74-like factor 2	412	0.7
chr2_4718727_4718878	0.33	Bend7	BEN domain containing 7	657	0.72
chr16_56279382_56279563	0.33	Impg2	interphotoreceptor matrix proteoglycan 2	9288	0.23
chr9_7871470_7871936	0.32	Birc3	baculoviral IAP repeat-containing 3	1154	0.48
chr11_35935845_35936006	0.32	Wwc1	WW, C2 and coiled-coil domain containing 1	44602	0.15
chr6_119387798_119387973	0.32	Adipor2	adiponectin receptor 2	801	0.67
chr2_61411366_61411534	0.32	Gm22338	predicted gene, 22338	81316	0.1
chr10_42762797_42763010	0.32	Sec63	SEC63-like (S. cerevisiae)	1097	0.46
chr10_42230294_42230483	0.32	Foxo3	forkhead box O3	27978	0.22
chr17_33667328_33667604	0.32	Hnrnpm	heterogeneous nuclear ribonucleoprotein M	896	0.43
chr13_96735297_96735468	0.32	Ankrd31	ankyrin repeat domain 31	12890	0.17
chr4_49691674_49691844	0.32	Ppp3r2	protein phosphatase 3, regulatory subunit B, alpha isoform (calcineurin B, type II)	9735	0.18
chr1_84056873_84057054	0.31	Pid1	phosphotyrosine interaction domain containing 1	3710	0.31
chr1_51751367_51751637	0.31	Gm28055	predicted gene 28055	4559	0.23
chr2_160865219_160865594	0.31	Zhx3	zinc fingers and homeoboxes 3	5775	0.14
chrX_145501791_145502198	0.31	Amot	angiomotin	3150	0.35
chr10_89505194_89505435	0.31	Nr1h4	nuclear receptor subfamily 1, group H, member 4	1335	0.49
chr1_136629198_136629381	0.31	Zfp281	zinc finger protein 281	4388	0.14
chr8_82773472_82774013	0.31	Zfp330	zinc finger protein 330	372	0.87
chr17_5043914_5044076	0.31	Arid1b	AT rich interactive domain 1B (SWI-like)	3417	0.32
chr6_122128951_122129135	0.31	Gm10319	predicted pseudogene 10319	7585	0.2
chr17_49304784_49304935	0.31	Gm17830	predicted gene, 17830	7382	0.19
chr11_120316780_120316958	0.31	Bahcc1	BAH domain and coiled-coil containing 1	27076	0.07
chr14_69417651_69417802	0.31	Gm16867	predicted gene, 16867	8751	0.12
chr7_115529118_115529280	0.31	Sox6	SRY (sex determining region Y)-box 6	68697	0.14
chr12_71296545_71296978	0.31	Dact1	dishevelled-binding antagonist of beta-catenin 1	13123	0.14
chr5_62761138_62761503	0.30	Arap2	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2	4800	0.29
chr14_31128100_31128302	0.30	Smim4	small integral membrane protein 4	637	0.55
chr11_23665861_23666058	0.30	Pex13	peroxisomal biogenesis factor 13	0	0.52
chr16_31004032_31004257	0.30	Gm15742	predicted gene 15742	30626	0.15
chr1_51892345_51892538	0.30	Myo1b	myosin IB	3860	0.18
chr3_97630832_97631292	0.30	Fmo5	flavin containing monooxygenase 5	2179	0.23
chr3_89896247_89896398	0.30	Gm42809	predicted gene 42809	16594	0.11
chr6_115658927_115659091	0.30	Raf1	v-raf-leukemia viral oncogene 1	16955	0.11
chr11_22434016_22434172	0.30	Gm12050	predicted gene 12050	5681	0.22
chr13_46294747_46294952	0.30	Stmnd1	stathmin domain containing 1	21128	0.24
chr10_19955042_19955243	0.30	Map3k5	mitogen-activated protein kinase kinase kinase 5	4087	0.26
chr4_76440655_76440825	0.30	Ptprd	protein tyrosine phosphatase, receptor type, D	9240	0.22
chr11_16843001_16843162	0.30	Egfros	epidermal growth factor receptor, opposite strand	12379	0.2
chr4_6273509_6273936	0.30	Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	1909	0.34
chr14_69635925_69636076	0.30	Gm27177	predicted gene 27177	4274	0.14
chr4_135255267_135255418	0.30	Clic4	chloride intracellular channel 4 (mitochondrial)	17472	0.14
chr4_57860254_57860405	0.29	Pakap	paralemmin A kinase anchor protein	6170	0.21
chr12_112590755_112591153	0.29	Inf2	inverted formin, FH2 and WH2 domain containing	1688	0.29
chr2_122737415_122737579	0.29	Bloc1s6os	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin, opposite strand	865	0.39
chr8_125034718_125034906	0.29	Gm45874	predicted gene 45874	15641	0.14
chr7_45051022_45051197	0.29	Prr12	proline rich 12	1772	0.12
chr6_38854042_38854267	0.29	Hipk2	homeodomain interacting protein kinase 2	16843	0.2
chr9_68889005_68889169	0.29	Rora	RAR-related orphan receptor alpha	233784	0.02
chr2_27706710_27707364	0.28	Rxra	retinoid X receptor alpha	2255	0.4
chr6_119383451_119383613	0.28	Adipor2	adiponectin receptor 2	5154	0.23
chr4_84548710_84548884	0.28	Bnc2	basonuclin 2	2178	0.44
chr7_134822153_134822304	0.28	Dock1	dedicator of cytokinesis 1	44773	0.16
chr14_34318672_34318993	0.28	Glud1	glutamate dehydrogenase 1	8105	0.1
chr1_21242608_21242925	0.28	Gsta3	glutathione S-transferase, alpha 3	2137	0.2
chr3_61089779_61089985	0.28	Gm37035	predicted gene, 37035	86096	0.09
chr8_105769002_105769227	0.28	Gfod2	glucose-fructose oxidoreductase domain containing 2	10450	0.1
chr11_43217118_43217287	0.28	Gm12144	predicted gene 12144	15062	0.19
chr11_116206347_116206509	0.28	Ten1	TEN1 telomerase capping complex subunit	4506	0.11
chr19_7765445_7765655	0.28	Slc22a26	solute carrier family 22 (organic cation transporter), member 26	37028	0.11
chr4_105200021_105200520	0.28	Plpp3	phospholipid phosphatase 3	42923	0.19
chr17_15827084_15827313	0.28	Rgmb	repulsive guidance molecule family member B	612	0.68
chr11_106464788_106464939	0.28	Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	22933	0.13
chr9_115307686_115307849	0.28	Stt3b	STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)	2654	0.24
chr7_135720125_135720308	0.28	Mki67	antigen identified by monoclonal antibody Ki 67	3855	0.2
chr17_47009670_47009958	0.27	Ubr2	ubiquitin protein ligase E3 component n-recognin 2	665	0.67
chr4_102581954_102582116	0.27	Pde4b	phosphodiesterase 4B, cAMP specific	5523	0.32
chr11_58614498_58614839	0.27	2210407C18Rik	RIKEN cDNA 2210407C18 gene	1176	0.25
chr3_74532167_74532327	0.27	Gm37050	predicted gene, 37050	208255	0.03
chr4_43399491_43399671	0.27	Rusc2	RUN and SH3 domain containing 2	1657	0.27
chr7_49398848_49399333	0.27	Nav2	neuron navigator 2	34369	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Evx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.8	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.2	0.7	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.2	0.5	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.5	GO:0006549	isoleucine metabolic process(GO:0006549)
0.1	0.4	GO:1903232	melanosome assembly(GO:1903232)
0.1	0.4	GO:0006068	ethanol catabolic process(GO:0006068)
0.1	0.3	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.1	0.2	GO:0006808	regulation of nitrogen utilization(GO:0006808)
0.1	0.5	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.1	0.4	GO:0001922	B-1 B cell homeostasis(GO:0001922)
0.1	0.2	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.1	0.2	GO:0034436	glycoprotein transport(GO:0034436)
0.1	0.2	GO:0006741	NADP biosynthetic process(GO:0006741)
0.1	0.2	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.1	0.2	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.1	0.4	GO:0001842	neural fold formation(GO:0001842)
0.1	0.3	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.1	0.2	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.1	0.2	GO:0071233	response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.1	0.2	GO:0090168	Golgi reassembly(GO:0090168)
0.1	0.2	GO:0032377	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.1	0.3	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.1	0.2	GO:0035973	aggrephagy(GO:0035973)
0.1	0.2	GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.1	0.2	GO:0070340	detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:2001025	positive regulation of response to drug(GO:2001025)
0.0	0.1	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.1	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:1900739	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	0.1	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.1	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.4	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.4	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.2	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.0	0.2	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.1	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.1	GO:0036022	limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0	0.3	GO:0000459	exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.0	0.2	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.2	GO:0016560	protein import into peroxisome matrix, docking(GO:0016560)
0.0	0.1	GO:0090296	regulation of mitochondrial DNA replication(GO:0090296)
0.0	0.1	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.2	GO:0019368	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0035093	spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.2	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.1	GO:1905206	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0009446	putrescine biosynthetic process(GO:0009446)
0.0	0.1	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.3	GO:0043482	cellular pigment accumulation(GO:0043482)
0.0	0.1	GO:0035672	oligopeptide transmembrane transport(GO:0035672)
0.0	0.1	GO:0034756	regulation of iron ion transport(GO:0034756)
0.0	0.1	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.0	GO:0071029	polyadenylation-dependent ncRNA catabolic process(GO:0043634) nuclear ncRNA surveillance(GO:0071029) nuclear polyadenylation-dependent rRNA catabolic process(GO:0071035) nuclear polyadenylation-dependent ncRNA catabolic process(GO:0071046)
0.0	0.2	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.2	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.1	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.3	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.6	GO:0071353	cellular response to interleukin-4(GO:0071353)
0.0	0.0	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.0	0.3	GO:0071380	cellular response to prostaglandin E stimulus(GO:0071380)
0.0	0.0	GO:2000809	positive regulation of synaptic vesicle clustering(GO:2000809)
0.0	0.1	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.1	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.4	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.2	GO:0043568	positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.0	0.1	GO:0038180	nerve growth factor signaling pathway(GO:0038180)
0.0	0.1	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.2	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.1	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.2	GO:0006851	mitochondrial calcium ion transport(GO:0006851)
0.0	0.2	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0035022	positive regulation of Rac protein signal transduction(GO:0035022)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0070814	hydrogen sulfide biosynthetic process(GO:0070814)
0.0	0.1	GO:0043380	regulation of memory T cell differentiation(GO:0043380)
0.0	0.1	GO:0034239	regulation of macrophage fusion(GO:0034239)
0.0	0.1	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0	0.0	GO:1900157	regulation of bone mineralization involved in bone maturation(GO:1900157)
0.0	0.1	GO:0044829	positive regulation by host of viral genome replication(GO:0044829)
0.0	0.2	GO:0097341	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0	0.2	GO:0006266	DNA ligation(GO:0006266)
0.0	0.2	GO:0010663	positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0	0.1	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.0	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0	0.1	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.0	0.1	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.2	GO:0043116	negative regulation of vascular permeability(GO:0043116)
0.0	0.1	GO:0043654	recognition of apoptotic cell(GO:0043654)
0.0	0.1	GO:0030432	peristalsis(GO:0030432)
0.0	0.0	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.1	GO:0006449	regulation of translational termination(GO:0006449)
0.0	0.0	GO:0071492	cellular response to UV-A(GO:0071492)
0.0	0.2	GO:0060856	establishment of blood-brain barrier(GO:0060856)
0.0	0.1	GO:0060020	Bergmann glial cell differentiation(GO:0060020)
0.0	0.0	GO:2000739	regulation of mesenchymal stem cell differentiation(GO:2000739)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.2	GO:0046855	inositol phosphate dephosphorylation(GO:0046855)
0.0	0.2	GO:0040034	regulation of development, heterochronic(GO:0040034)
0.0	0.0	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.0	0.1	GO:1902774	late endosome to lysosome transport(GO:1902774)
0.0	0.1	GO:0070836	caveola assembly(GO:0070836)
0.0	0.0	GO:0046292	formaldehyde metabolic process(GO:0046292)
0.0	0.0	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.0	0.0	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.1	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.0	0.0	GO:0003330	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0	0.1	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.1	GO:0052405	negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0	0.2	GO:0045475	locomotor rhythm(GO:0045475)
0.0	0.0	GO:0010536	positive regulation of activation of Janus kinase activity(GO:0010536)
0.0	0.1	GO:0090031	positive regulation of steroid hormone biosynthetic process(GO:0090031)
0.0	0.1	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.0	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	0.0	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.0	0.0	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0061010	gall bladder development(GO:0061010)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.0	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0	0.0	GO:1903999	negative regulation of eating behavior(GO:1903999)
0.0	0.0	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.1	GO:0070633	transepithelial transport(GO:0070633)
0.0	0.1	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0	0.0	GO:0006069	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.1	GO:0006450	regulation of translational fidelity(GO:0006450)
0.0	0.0	GO:0072553	terminal button organization(GO:0072553)
0.0	0.1	GO:0035627	ceramide transport(GO:0035627)
0.0	0.0	GO:0021530	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0	0.0	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0009826	unidimensional cell growth(GO:0009826)
0.0	0.2	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0021960	anterior commissure morphogenesis(GO:0021960)
0.0	0.1	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
0.0	0.0	GO:0010982	regulation of high-density lipoprotein particle clearance(GO:0010982)
0.0	0.1	GO:2001256	regulation of store-operated calcium entry(GO:2001256)
0.0	0.0	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0	0.1	GO:0002115	store-operated calcium entry(GO:0002115)
0.0	0.0	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.0	GO:0070350	white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.0	0.1	GO:0034398	telomere tethering at nuclear periphery(GO:0034398)
0.0	0.0	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.1	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.0	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.1	GO:0006538	glutamate catabolic process(GO:0006538)
0.0	0.0	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.2	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.0	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.0	GO:0061146	Peyer's patch morphogenesis(GO:0061146)
0.0	0.0	GO:0032513	negative regulation of protein phosphatase type 2B activity(GO:0032513)
0.0	0.0	GO:0003162	atrioventricular node development(GO:0003162)
0.0	0.1	GO:0021859	pyramidal neuron differentiation(GO:0021859)
0.0	0.0	GO:0071336	regulation of hair follicle cell proliferation(GO:0071336)
0.0	0.1	GO:0045217	cell-cell junction maintenance(GO:0045217)
0.0	0.0	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.0	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.0	GO:0090289	regulation of osteoclast proliferation(GO:0090289)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.0	0.0	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.0	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.0	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.0	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.0	0.1	GO:0060623	regulation of chromosome condensation(GO:0060623)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.0	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.2	GO:0031954	positive regulation of protein autophosphorylation(GO:0031954)
0.0	0.0	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.0	GO:0035928	rRNA import into mitochondrion(GO:0035928)
0.0	0.1	GO:0043586	tongue development(GO:0043586)
0.0	0.0	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.0	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.0	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.0	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.2	GO:0000028	ribosomal small subunit assembly(GO:0000028)
0.0	0.1	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.0	GO:0048023	positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.0	GO:0061589	calcium activated phosphatidylserine scrambling(GO:0061589)
0.0	0.1	GO:0031065	positive regulation of histone deacetylation(GO:0031065)
0.0	0.1	GO:0014883	transition between fast and slow fiber(GO:0014883)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0071001	U4/U6 snRNP(GO:0071001)
0.1	0.3	GO:0045098	type III intermediate filament(GO:0045098)
0.1	0.2	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.4	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.2	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.3	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0	0.2	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.0	0.1	GO:0097413	Lewy body(GO:0097413)
0.0	0.2	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.4	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.1	GO:0017133	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0	0.2	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306)
0.0	0.2	GO:0097470	ribbon synapse(GO:0097470)
0.0	0.1	GO:1990111	spermatoproteasome complex(GO:1990111)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.2	GO:0001939	female pronucleus(GO:0001939)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.2	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.0	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.0	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.5	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.0	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.0	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.2	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.0	GO:1990246	uniplex complex(GO:1990246)
0.0	0.0	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)
0.0	0.1	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.0	GO:0042825	TAP complex(GO:0042825)
0.0	0.3	GO:0044295	axonal growth cone(GO:0044295)
0.0	0.0	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.0	GO:1990130	Iml1 complex(GO:1990130)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	0.4	GO:0055100	adiponectin binding(GO:0055100)
0.1	0.4	GO:0004771	sterol esterase activity(GO:0004771)
0.1	0.4	GO:0030620	U2 snRNA binding(GO:0030620)
0.1	0.3	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1	0.2	GO:0038181	bile acid receptor activity(GO:0038181)
0.1	0.4	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.1	0.3	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1	0.2	GO:0070538	oleic acid binding(GO:0070538)
0.1	0.2	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.1	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.2	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.1	0.2	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.1	0.3	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.2	GO:0070728	leucine binding(GO:0070728)
0.0	0.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.2	GO:0001602	pancreatic polypeptide receptor activity(GO:0001602)
0.0	0.3	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.2	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.2	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.2	GO:0102337	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.2	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.6	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.2	GO:0033695	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.2	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.2	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.0	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.0	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0	0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.2	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.6	GO:0047376	prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0	0.3	GO:0043425	bHLH transcription factor binding(GO:0043425)
0.0	0.1	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
0.0	0.1	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.1	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0	0.1	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0080011	pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011)
0.0	0.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.2	GO:0048185	activin binding(GO:0048185)
0.0	0.1	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.2	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.0	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
0.0	0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.0	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.1	GO:1990405	protein antigen binding(GO:1990405)
0.0	0.0	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.5	GO:0042169	SH2 domain binding(GO:0042169)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0030375	thyroid hormone receptor coactivator activity(GO:0030375)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.2	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.0	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0000104	succinate dehydrogenase activity(GO:0000104)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.0	GO:0016531	copper chaperone activity(GO:0016531) superoxide dismutase copper chaperone activity(GO:0016532)
0.0	0.4	GO:0070888	E-box binding(GO:0070888)
0.0	0.1	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.0	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.1	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0	0.1	GO:0043996	histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.0	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.0	GO:0052832	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.0	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.4	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.0	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.0	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.2	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.1	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.0	0.1	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.0	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.6	GO:0043765	integrase activity(GO:0008907) T/G mismatch-specific endonuclease activity(GO:0043765) retroviral integrase activity(GO:0044823) retroviral 3' processing activity(GO:0044824)
0.0	0.0	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.0	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.0	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0030159	receptor signaling complex scaffold activity(GO:0030159)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.0	0.5	PID IGF1 PATHWAY	IGF1 pathway
0.0	0.4	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.8	PID HES HEY PATHWAY	Notch-mediated HES/HEY network
0.0	0.7	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	0.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.2	PID ALK2 PATHWAY	ALK2 signaling events
0.0	0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.0	0.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.0	0.5	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.0	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.0	0.2	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.0	0.1	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.4	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.6	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.2	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.3	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.2	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.3	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.2	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.3	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.2	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.3	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.4	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.3	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.0	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.3	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.5	REACTOME NETRIN1 SIGNALING	Genes involved in Netrin-1 signaling
0.3	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.3	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	REACTOME ADP SIGNALLING THROUGH P2RY1	Genes involved in ADP signalling through P2Y purinoceptor 1
0.2	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM	Genes involved in Branched-chain amino acid catabolism
0.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.1	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.1	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation

Results for Evx2

Z-value: 1.22

Motif logo

Transcription factors associated with Evx2

Activity of the Evx2 motif across conditions

Conditions sorted by the z-value of the Evx2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Evx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: