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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Fosb

Z-value: 1.49

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Transcription factors associated with Fosb

Gene Symbol	Gene ID	Gene Info
Fosb Ensembl NCBI MGI UniProt	ENSMUSG00000003545.2	Fosb

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Fosb	chr7_19320068_19320228	10097	0.066494	-0.85	3.4e-02	Click!
Fosb	chr7_19310289_19310447	317	0.728755	-0.75	8.5e-02	Click!
Fosb	chr7_19316542_19316693	6566	0.071981	-0.74	9.1e-02	Click!
Fosb	chr7_19308580_19308766	927	0.303846	-0.74	9.6e-02	Click!
Fosb	chr7_19309024_19309201	488	0.566308	-0.69	1.3e-01	Click!

Activity of the Fosb motif across conditions

Conditions sorted by the z-value of the Fosb motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr18_81319673_81319824	1.82	Gm30192	predicted gene, 30192	55040	0.14
chr8_128648206_128648359	1.38	Gm26002	predicted gene, 26002	2715	0.24
chr17_25127135_25127453	1.20	Clcn7	chloride channel, voltage-sensitive 7	6097	0.1
chr8_128333459_128333621	1.15	Nrp1	neuropilin 1	25064	0.19
chr11_16781411_16781603	1.12	Egfr	epidermal growth factor receptor	29277	0.16
chr19_40153747_40153898	1.12	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	33464	0.13
chr9_74947099_74947265	1.12	Fam214a	family with sequence similarity 214, member A	5702	0.22
chr4_52815809_52815985	1.10	Olfr275	olfactory receptor 275	1293	0.37
chr5_135693560_135693734	0.95	Por	P450 (cytochrome) oxidoreductase	4489	0.12
chr15_96930772_96930923	0.88	Rpl10a-ps3	ribosomal protein L10A, pseudogene 3	7442	0.28
chr17_64765537_64765696	0.84	Dreh	down-regulated in hepatocellular carcinoma	1495	0.41
chr3_99188109_99188313	0.81	Gm18982	predicted gene, 18982	6930	0.13
chrX_98051224_98051403	0.75	Gm14802	predicted gene 14802	10938	0.3
chr9_44079482_44079643	0.73	Usp2	ubiquitin specific peptidase 2	5377	0.08
chr1_178600841_178601326	0.70	Gm24405	predicted gene, 24405	35822	0.18
chr4_6273243_6273469	0.65	Cyp7a1	cytochrome P450, family 7, subfamily a, polypeptide 1	2275	0.3
chr15_3411405_3411556	0.63	Ghr	growth hormone receptor	60164	0.13
chr10_87880054_87880205	0.62	Igf1os	insulin-like growth factor 1, opposite strand	16748	0.19
chr5_135736099_135736335	0.62	Mir7034	microRNA 7034	328	0.49
chr2_65267631_65267817	0.61	Gm13592	predicted gene 13592	9693	0.17
chr10_111583961_111584156	0.61	4933440J02Rik	RIKEN cDNA 4933440J02 gene	10215	0.16
chr13_31820560_31820717	0.60	Foxc1	forkhead box C1	14005	0.16
chr8_126591993_126592171	0.59	Irf2bp2	interferon regulatory factor 2 binding protein 2	1904	0.39
chr2_130819037_130819547	0.59	4930402H24Rik	RIKEN cDNA 4930402H24 gene	5000	0.18
chr18_20971049_20971351	0.58	Rnf125	ring finger protein 125	9728	0.2
chr1_60833760_60833934	0.57	Gm11581	predicted gene 11581	24731	0.11
chr13_113168591_113168750	0.56	Gzmk	granzyme K	12227	0.13
chr14_47983137_47983357	0.56	Gm49304	predicted gene, 49304	10556	0.15
chr3_18210346_18210497	0.56	Gm23686	predicted gene, 23686	32796	0.17
chr12_104089620_104089844	0.55	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	9083	0.1
chr1_162815471_162815637	0.54	Fmo4	flavin containing monooxygenase 4	1582	0.37
chr16_70331018_70331193	0.54	Gbe1	glucan (1,4-alpha-), branching enzyme 1	16971	0.24
chr12_104109060_104109241	0.54	Gm23289	predicted gene, 23289	133	0.92
chr1_193870865_193871025	0.54	Gm21362	predicted gene, 21362	3936	0.37
chr3_116784094_116784363	0.50	Agl	amylo-1,6-glucosidase, 4-alpha-glucanotransferase	2478	0.21
chr12_105728790_105728966	0.49	Ak7	adenylate kinase 7	10022	0.17
chr11_59226278_59226466	0.49	Arf1	ADP-ribosylation factor 1	1790	0.2
chr3_61217484_61217722	0.48	Gm37719	predicted gene, 37719	73843	0.1
chr11_4190659_4190839	0.48	Tbc1d10a	TBC1 domain family, member 10a	3927	0.12
chr11_16836119_16836554	0.48	Egfros	epidermal growth factor receptor, opposite strand	5634	0.23
chr9_96823694_96824186	0.48	Gm8520	predicted gene 8520	9606	0.15
chr19_26753091_26753242	0.47	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	434	0.87
chr2_167325906_167326068	0.46	B4galt5	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5	12087	0.18
chr15_3413229_3413380	0.46	Ghr	growth hormone receptor	58340	0.14
chr2_148018834_148018985	0.46	9030622O22Rik	RIKEN cDNA 9030622O22 gene	19361	0.17
chrX_60462043_60462214	0.45	Gm7073	predicted gene 7073	5933	0.23
chr11_106490027_106490381	0.45	Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	2352	0.23
chr1_45672893_45673066	0.45	Gm23216	predicted gene, 23216	12583	0.19
chr2_126867909_126868096	0.45	Gm14212	predicted gene 14212	3499	0.2
chr15_3514160_3514323	0.44	Ghr	growth hormone receptor	42597	0.18
chr3_88717858_88718018	0.43	Rit1	Ras-like without CAAX 1	1027	0.3
chr9_116194113_116194264	0.43	Gm4668	predicted gene 4668	5008	0.18
chr2_132656980_132657153	0.43	Rpl23a-ps4	ribosomal protein L23A, pseudogene 4	5176	0.13
chr1_91463744_91463928	0.43	Per2	period circadian clock 2	4512	0.13
chr12_79501822_79502159	0.42	Rad51b	RAD51 paralog B	174637	0.03
chr3_137511395_137511566	0.42	Gm4861	predicted gene 4861	41142	0.16
chr18_35813778_35813929	0.42	Ube2d2a	ubiquitin-conjugating enzyme E2D 2A	12546	0.09
chr13_35434169_35434335	0.42	Gm48703	predicted gene, 48703	38869	0.17
chr5_138788893_138789272	0.41	Fam20c	family with sequence similarity 20, member C	308	0.9
chr10_121457902_121458053	0.40	Rassf3	Ras association (RalGDS/AF-6) domain family member 3	4236	0.14
chr7_98352590_98353259	0.40	Tsku	tsukushi, small leucine rich proteoglycan	7155	0.18
chr16_93367939_93368144	0.40	1810044K17Rik	RIKEN cDNA 1810044K17 gene	198	0.89
chr18_33335416_33335586	0.39	Gm5503	predicted gene 5503	49454	0.16
chr1_70918439_70918607	0.39	Gm16236	predicted gene 16236	121507	0.06
chr15_42674825_42675078	0.39	Gm17473	predicted gene, 17473	1290	0.44
chr3_145995608_145995781	0.38	Syde2	synapse defective 1, Rho GTPase, homolog 2 (C. elegans)	2023	0.3
chr8_79710908_79711237	0.38	Abce1	ATP-binding cassette, sub-family E (OABP), member 1	578	0.48
chr12_104850467_104850964	0.37	4930408O17Rik	RIKEN cDNA 4930408O17 gene	6656	0.19
chr9_103507084_103507251	0.37	Tmem108	transmembrane protein 108	13556	0.1
chr4_139601582_139602248	0.37	Gm21969	predicted gene 21969	1271	0.37
chr1_85246945_85247096	0.36	Gm16028	predicted gene 16028	169	0.83
chr1_137034426_137034730	0.36	Gm23763	predicted gene, 23763	44308	0.16
chr17_10702814_10703005	0.36	Pacrg	PARK2 co-regulated	71842	0.11
chr7_51868214_51868365	0.36	Gas2	growth arrest specific 2	4385	0.17
chr14_89610572_89610930	0.36	Gm25415	predicted gene, 25415	96054	0.09
chr18_8327970_8328137	0.35	Gm5500	predicted pseudogene 5500	87076	0.09
chr15_58972603_58972890	0.35	Mtss1	MTSS I-BAR domain containing 1	207	0.92
chr6_108313163_108313314	0.35	Itpr1	inositol 1,4,5-trisphosphate receptor 1	43016	0.18
chr11_86629518_86629733	0.35	Gm11478	predicted gene 11478	1401	0.38
chr2_142804438_142804612	0.35	Gm22310	predicted gene, 22310	17629	0.25
chr4_108363811_108364169	0.34	Shisal2a	shisa like 2A	19359	0.12
chr6_91712952_91713256	0.34	Gm44981	predicted gene 44981	174	0.92
chr11_119777405_119777556	0.34	Rptor	regulatory associated protein of MTOR, complex 1	21293	0.16
chr18_38406873_38407073	0.34	Ndfip1	Nedd4 family interacting protein 1	3423	0.18
chr7_118104788_118104966	0.34	Rps15a	ribosomal protein S15A	10351	0.17
chr1_67187795_67187968	0.33	Gm15668	predicted gene 15668	61319	0.11
chr18_12686874_12687043	0.33	Ttc39c	tetratricopeptide repeat domain 39C	2770	0.21
chr4_84131285_84131460	0.33	Gm12414	predicted gene 12414	1083	0.59
chr18_53864446_53864629	0.32	Csnk1g3	casein kinase 1, gamma 3	2349	0.42
chr1_10604540_10604691	0.32	Gm25253	predicted gene, 25253	48955	0.13
chr15_58965948_58966356	0.32	Mtss1	MTSS I-BAR domain containing 1	6387	0.16
chr2_85061178_85061331	0.31	Tnks1bp1	tankyrase 1 binding protein 1	290	0.85
chr2_59997998_59998149	0.31	Gm13574	predicted gene 13574	5729	0.19
chr5_140616803_140616967	0.31	Lfng	LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	5200	0.14
chr14_20291279_20291481	0.31	Nudt13	nudix (nucleoside diphosphate linked moiety X)-type motif 13	3317	0.16
chr6_71420889_71421080	0.31	Gm44130	predicted gene, 44130	14123	0.1
chr18_85490238_85490398	0.31	Gm7612	predicted gene 7612	226407	0.02
chr14_17900415_17900617	0.31	Thrb	thyroid hormone receptor beta	62305	0.13
chr12_79864462_79864614	0.30	9430078K24Rik	RIKEN cDNA 9430078K24 gene	60195	0.12
chr4_117937047_117937475	0.30	Artn	artemin	7498	0.12
chr14_74650101_74650379	0.30	Htr2a	5-hydroxytryptamine (serotonin) receptor 2A	9400	0.24
chr2_18048778_18049088	0.30	Skida1	SKI/DACH domain containing 1	98	0.94
chr17_23554288_23554546	0.30	Casp16	caspase 16, apoptosis-related cysteine peptidase	929	0.34
chr2_74100092_74100243	0.30	A630050E04Rik	RIKEN cDNA A630050E04 gene	2175	0.32
chr11_60240852_60241067	0.30	Gm12265	predicted gene 12265	149	0.92
chr11_70972275_70972426	0.30	Rpain	RPA interacting protein	453	0.66
chr19_14692311_14692469	0.30	Gm26026	predicted gene, 26026	26090	0.21
chr19_27492565_27492719	0.30	Gm50101	predicted gene, 50101	19866	0.23
chr8_80962240_80962391	0.29	Gm27048	predicted gene, 27048	23648	0.15
chr14_31112566_31112718	0.29	Smim4	small integral membrane protein 4	16196	0.1
chr6_136938692_136939081	0.29	Arhgdib	Rho, GDP dissociation inhibitor (GDI) beta	705	0.59
chr19_8757228_8757608	0.29	Nxf1	nuclear RNA export factor 1	268	0.68
chr2_130488707_130488873	0.28	9530056E24Rik	RIKEN cDNA 9530056E24 gene	35205	0.08
chr7_137621172_137621473	0.28	Gm45683	predicted gene 45683	27767	0.21
chr4_76424963_76425155	0.28	Ptprd	protein tyrosine phosphatase, receptor type, D	24921	0.18
chr19_39282868_39283045	0.28	Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	4118	0.26
chr2_168524880_168525160	0.28	Nfatc2	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2	27256	0.2
chr7_39977983_39978150	0.28	Gm44992	predicted gene 44992	8	0.98
chr19_15007147_15007306	0.27	Gm5513	predicted pseudogene 5513	46460	0.21
chr8_61585158_61585376	0.27	Palld	palladin, cytoskeletal associated protein	5872	0.3
chr2_129582332_129582507	0.27	Sirpa	signal-regulatory protein alpha	10416	0.17
chr8_90870510_90870662	0.27	Gm45640	predicted gene 45640	5995	0.14
chr2_31742282_31742433	0.27	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	17586	0.14
chr16_91433633_91433806	0.27	Gm46562	predicted gene, 46562	24702	0.08
chrX_10259432_10259607	0.26	Otc	ornithine transcarbamylase	7152	0.26
chr11_98294355_98294506	0.26	Gm20644	predicted gene 20644	9048	0.1
chr4_105557523_105557702	0.26	Gm12726	predicted gene 12726	20728	0.24
chr6_87277564_87277945	0.26	Gm44418	predicted gene, 44418	9	0.96
chr16_38289983_38290198	0.26	Nr1i2	nuclear receptor subfamily 1, group I, member 2	4734	0.16
chr19_21820366_21820517	0.26	Gm50130	predicted gene, 50130	13315	0.21
chr7_99173461_99173666	0.26	Dgat2	diacylglycerol O-acyltransferase 2	3457	0.17
chr5_66035556_66035796	0.25	Rbm47	RNA binding motif protein 47	18876	0.11
chr9_25504836_25504987	0.25	Eepd1	endonuclease/exonuclease/phosphatase family domain containing 1	22044	0.17
chr8_124014864_124015025	0.25	Taf5l	TATA-box binding protein associated factor 5 like	5996	0.11
chr8_56230092_56230281	0.25	Hpgd	hydroxyprostaglandin dehydrogenase 15 (NAD)	64399	0.12
chr11_16914824_16915305	0.25	Egfr	epidermal growth factor receptor	9879	0.18
chr6_84043664_84043821	0.25	Gm7498	predicted gene 7498	12154	0.15
chr7_18948266_18948455	0.25	Nova2	NOVA alternative splicing regulator 2	22472	0.08
chr10_66928213_66928377	0.25	Gm26576	predicted gene, 26576	7993	0.17
chr1_58729553_58729738	0.25	Cflar	CASP8 and FADD-like apoptosis regulator	907	0.49
chr16_59956556_59956707	0.25	Epha6	Eph receptor A6	49090	0.18
chr15_84924832_84925200	0.25	Nup50	nucleoporin 50	1567	0.26
chr11_16702482_16702935	0.25	Gm25698	predicted gene, 25698	30003	0.15
chr4_108234244_108234395	0.24	Zyg11b	zyg-ll family member B, cell cycle regulator	7719	0.16
chr11_101464329_101464518	0.24	Rnd2	Rho family GTPase 2	576	0.46
chr2_32517571_32517751	0.24	Gm13412	predicted gene 13412	7370	0.1
chr16_30375250_30375569	0.24	Atp13a3	ATPase type 13A3	13076	0.2
chr13_101540438_101540589	0.24	Gm47533	predicted gene, 47533	4693	0.19
chr9_68009384_68009551	0.24	Gm20745	predicted gene, 20745	16247	0.23
chr19_42017962_42018130	0.24	Ubtd1	ubiquitin domain containing 1	897	0.43
chr19_12633216_12633544	0.24	Glyat	glycine-N-acyltransferase	72	0.94
chr5_21702946_21703133	0.24	Napepld	N-acyl phosphatidylethanolamine phospholipase D	1643	0.28
chr15_58947619_58947948	0.24	Mtss1	MTSS I-BAR domain containing 1	5797	0.14
chr16_77535131_77535288	0.24	Gm36963	predicted gene, 36963	4673	0.14
chr16_20540431_20540616	0.24	Ap2m1	adaptor-related protein complex 2, mu 1 subunit	100	0.9
chr3_149220840_149220991	0.24	Gm10287	predicted gene 10287	4830	0.24
chr11_106410149_106410681	0.24	Icam2	intercellular adhesion molecule 2	22340	0.13
chr16_55967011_55967191	0.24	Rpl24	ribosomal protein L24	554	0.46
chr4_117126763_117126969	0.24	Tctex1d4	Tctex1 domain containing 4	53	0.9
chr14_76715025_76715203	0.24	1700108F19Rik	RIKEN cDNA 1700108F19 gene	33360	0.15
chr12_33369704_33369869	0.24	Atxn7l1	ataxin 7-like 1	2462	0.24
chr5_88367022_88367405	0.24	Amtn	amelotin	8895	0.17
chr1_35759768_35759937	0.24	Gm25634	predicted gene, 25634	1750	0.42
chr4_140862219_140862586	0.24	4930515B02Rik	RIKEN cDNA 4930515B02 gene	10291	0.12
chr14_89612108_89612276	0.23	Gm25415	predicted gene, 25415	94613	0.09
chr19_40227668_40227819	0.23	Pdlim1	PDZ and LIM domain 1 (elfin)	3062	0.2
chr1_4670727_4670906	0.23	Gm6085	predicted gene 6085	18587	0.13
chr9_122856843_122857012	0.23	Zfp445	zinc finger protein 445	200	0.89
chr6_121145100_121145251	0.23	Mical3	microtubule associated monooxygenase, calponin and LIM domain containing 3	14176	0.14
chr15_59068526_59068830	0.23	Mtss1	MTSS I-BAR domain containing 1	13214	0.22
chr4_106439943_106440414	0.23	Usp24	ubiquitin specific peptidase 24	11685	0.15
chr3_27712516_27712706	0.23	Fndc3b	fibronectin type III domain containing 3B	1304	0.58
chr15_62743599_62743898	0.23	Gm22521	predicted gene, 22521	49453	0.17
chr10_80342748_80342921	0.23	Adamtsl5	ADAMTS-like 5	2404	0.1
chr12_34664877_34665034	0.22	Gm47357	predicted gene, 47357	36317	0.19
chr10_59884883_59885114	0.22	Dnajb12	DnaJ heat shock protein family (Hsp40) member B12	5372	0.16
chr7_128529551_128529973	0.22	Bag3	BCL2-associated athanogene 3	6146	0.12
chr14_47533422_47533895	0.22	Fbxo34	F-box protein 34	7579	0.12
chr1_177188880_177189041	0.22	Gm37706	predicted gene, 37706	18098	0.16
chr8_111246376_111246527	0.22	Glg1	golgi apparatus protein 1	12749	0.16
chr11_12463629_12463800	0.22	Cobl	cordon-bleu WH2 repeat	1038	0.69
chr9_65198022_65198189	0.22	Gm25313	predicted gene, 25313	1418	0.27
chr8_64877797_64877973	0.22	Klhl2	kelch-like 2, Mayven	27868	0.11
chr15_62337746_62337903	0.22	Pvt1	Pvt1 oncogene	115221	0.06
chr2_27727019_27727170	0.22	Rxra	retinoid X receptor alpha	1875	0.44
chr3_62458537_62458746	0.22	Dhx36	DEAH (Asp-Glu-Ala-His) box polypeptide 36	13946	0.24
chr11_101111260_101111411	0.22	Retreg3	reticulophagy regulator family member 3	8430	0.08
chr17_80772516_80772751	0.22	Map4k3	mitogen-activated protein kinase kinase kinase kinase 3	44148	0.15
chr1_91445260_91445618	0.22	Per2	period circadian clock 2	4426	0.13
chr11_120821685_120822756	0.22	Fasn	fatty acid synthase	1560	0.22
chr10_81409520_81409671	0.22	Gm16104	predicted gene 16104	20	0.92
chr8_72134846_72135406	0.22	Tpm4	tropomyosin 4	103	0.92
chr4_108090689_108090857	0.21	Mir6397	microRNA 6397	3416	0.18
chr16_43464306_43464503	0.21	Zbtb20	zinc finger and BTB domain containing 20	39210	0.15
chr2_105252035_105252217	0.21	Them7	thioesterase superfamily member 7	27784	0.2
chr16_35484667_35484833	0.21	Pdia5	protein disulfide isomerase associated 5	5839	0.17
chr8_107293609_107293943	0.21	Nfat5	nuclear factor of activated T cells 5	217	0.94
chr12_75545967_75546292	0.21	Ppp2r5e	protein phosphatase 2, regulatory subunit B', epsilon	3545	0.25
chr6_108510231_108510410	0.21	Itpr1	inositol 1,4,5-trisphosphate receptor 1	2007	0.27
chr3_52296364_52296605	0.21	Gm38034	predicted gene, 38034	14243	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Fosb

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.4	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.4	GO:0071895	odontoblast differentiation(GO:0071895)
0.1	0.3	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:0035441	cell migration involved in vasculogenesis(GO:0035441)
0.1	0.3	GO:1903300	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.1	GO:0097212	lysosomal membrane organization(GO:0097212)
0.0	0.2	GO:0072338	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.1	GO:0021943	formation of radial glial scaffolds(GO:0021943)
0.0	0.1	GO:0001983	baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0	0.2	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.0	0.3	GO:0042737	drug catabolic process(GO:0042737)
0.0	0.1	GO:1990314	cellular response to insulin-like growth factor stimulus(GO:1990314)
0.0	0.1	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.0	0.2	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.2	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.1	GO:0014732	skeletal muscle atrophy(GO:0014732)
0.0	0.1	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.2	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.2	GO:0070857	regulation of bile acid biosynthetic process(GO:0070857)
0.0	0.1	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0	0.1	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.1	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.0	0.1	GO:0071680	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.2	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.1	GO:0009838	abscission(GO:0009838)
0.0	0.1	GO:0060978	angiogenesis involved in coronary vascular morphogenesis(GO:0060978)
0.0	0.1	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway(GO:0007208)
0.0	0.1	GO:0003278	apoptotic process involved in heart morphogenesis(GO:0003278)
0.0	0.1	GO:1903899	positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0060510	Type II pneumocyte differentiation(GO:0060510)
0.0	0.1	GO:1903999	negative regulation of eating behavior(GO:1903999)
0.0	0.1	GO:0072092	ureteric bud invasion(GO:0072092)
0.0	0.4	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.1	GO:2000611	positive regulation of thyroid hormone generation(GO:2000611)
0.0	0.1	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.1	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.1	GO:0007619	courtship behavior(GO:0007619)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:0021960	anterior commissure morphogenesis(GO:0021960)
0.0	0.2	GO:0000054	ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.0	0.1	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.2	GO:0043651	linoleic acid metabolic process(GO:0043651)
0.0	0.1	GO:0031145	anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.0	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.0	0.1	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.0	0.0	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.2	GO:0016973	poly(A)+ mRNA export from nucleus(GO:0016973)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.0	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0	0.0	GO:0042505	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0	0.0	GO:0070175	positive regulation of enamel mineralization(GO:0070175)
0.0	0.0	GO:1904339	negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.0	0.1	GO:0015824	proline transport(GO:0015824)
0.0	0.1	GO:0048672	positive regulation of collateral sprouting(GO:0048672)
0.0	0.1	GO:1902969	mitotic DNA replication(GO:1902969)
0.0	0.0	GO:0061146	Peyer's patch morphogenesis(GO:0061146)
0.0	0.1	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.3	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.0	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.0	0.0	GO:0051295	establishment of meiotic spindle localization(GO:0051295)
0.0	0.0	GO:0046726	positive regulation by virus of viral protein levels in host cell(GO:0046726)
0.0	0.0	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.0	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.1	GO:0006297	nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0	0.2	GO:0070884	regulation of calcineurin-NFAT signaling cascade(GO:0070884)
0.0	0.0	GO:0030035	microspike assembly(GO:0030035)
0.0	0.0	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.1	GO:0035845	photoreceptor cell outer segment organization(GO:0035845)
0.0	0.1	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.2	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.2	GO:1990357	terminal web(GO:1990357)
0.0	0.1	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.4	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0042567	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0000811	GINS complex(GO:0000811)
0.0	0.2	GO:0000346	transcription export complex(GO:0000346)
0.0	0.3	GO:0030014	CCR4-NOT complex(GO:0030014)
0.0	0.1	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.0	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0090543	Flemming body(GO:0090543)
0.0	0.0	GO:0097513	myosin II filament(GO:0097513)
0.0	0.0	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.2	GO:0002102	podosome(GO:0002102)
0.0	0.2	GO:0005852	eukaryotic translation initiation factor 3 complex(GO:0005852)
0.0	0.1	GO:0032039	integrator complex(GO:0032039)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.1	0.2	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.4	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.2	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.8	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.2	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.1	GO:0019960	C-X3-C chemokine binding(GO:0019960)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.3	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.1	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.0	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.0	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0017099	very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.0	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.0	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0016443	bidentate ribonuclease III activity(GO:0016443)
0.0	0.0	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.2	GO:0008157	protein phosphatase 1 binding(GO:0008157)
0.0	0.2	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.0	GO:0001031	RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.3	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0	0.1	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.1	GO:0051880	G-quadruplex DNA binding(GO:0051880)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.2	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.9	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	PID ARF 3PATHWAY	Arf1 pathway
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.1	PID IGF1 PATHWAY	IGF1 pathway
0.6	PID AR TF PATHWAY	Regulation of Androgen receptor activity

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME SIGNALLING TO P38 VIA RIT AND RIN	Genes involved in Signalling to p38 via RIT and RIN
0.3	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.3	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.2	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.3	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.2	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.3	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL	Genes involved in Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell