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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Foxb1

Z-value: 1.39

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Transcription factors associated with Foxb1

Gene Symbol	Gene ID	Gene Info
Foxb1 Ensembl NCBI MGI UniProt	ENSMUSG00000059246.4	Foxb1

Activity of the Foxb1 motif across conditions

Conditions sorted by the z-value of the Foxb1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_16888258_16888409	0.91	Egfr	epidermal growth factor receptor	10183	0.2
chr2_8124301_8124468	0.84	Gm13254	predicted gene 13254	23481	0.29
chr11_16588986_16589143	0.76	Gm12663	predicted gene 12663	47002	0.12
chr7_26781568_26782082	0.71	Cyp2b19	cytochrome P450, family 2, subfamily b, polypeptide 19	15270	0.15
chr2_25384633_25384784	0.69	Sapcd2	suppressor APC domain containing 2	8748	0.07
chr16_45168608_45168759	0.68	Atg3	autophagy related 3	2800	0.24
chr17_40806286_40806473	0.67	Crisp2	cysteine-rich secretory protein 2	624	0.67
chrX_47259642_47259793	0.65	Gm14609	predicted gene 14609	121617	0.06
chr4_65080374_65080537	0.65	Pappa	pregnancy-associated plasma protein A	43719	0.19
chr13_56648096_56648259	0.64	Tgfbi	transforming growth factor, beta induced	16964	0.19
chr7_99899121_99899281	0.60	Xrra1	X-ray radiation resistance associated 1	3505	0.15
chr9_114632451_114632621	0.55	Cnot10	CCR4-NOT transcription complex, subunit 10	7427	0.16
chr5_150264404_150264568	0.53	Fry	FRY microtubule binding protein	4719	0.21
chr6_141381408_141381711	0.52	Gm10400	predicted gene 10400	41006	0.17
chr19_20723027_20723214	0.51	Aldh1a7	aldehyde dehydrogenase family 1, subfamily A7	4442	0.3
chr10_71193153_71193343	0.51	1700113B09Rik	RIKEN cDNA 1700113B09 gene	8497	0.12
chr5_148936597_148936854	0.47	Katnal1	katanin p60 subunit A-like 1	7405	0.1
chr15_10972894_10973115	0.47	Amacr	alpha-methylacyl-CoA racemase	8752	0.15
chr1_162986828_162987029	0.46	Fmo3	flavin containing monooxygenase 3	2400	0.25
chr8_40907855_40908028	0.45	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	9503	0.16
chr9_20745269_20745579	0.45	Olfm2	olfactomedin 2	925	0.51
chr4_87880355_87880506	0.43	Mllt3	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	5888	0.31
chr7_97423614_97423975	0.42	Thrsp	thyroid hormone responsive	6064	0.14
chr8_73054856_73055038	0.41	Mir28b	microRNA 28b	38435	0.17
chr7_84212215_84212389	0.41	Gm44826	predicted gene 44826	1788	0.29
chrX_106036704_106036855	0.41	Atp7a	ATPase, Cu++ transporting, alpha polypeptide	9457	0.17
chr8_114154739_114154891	0.41	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	21173	0.24
chr19_10590708_10591077	0.40	Cyb561a3	cytochrome b561 family, member A3	12880	0.08
chr11_107270789_107270983	0.40	Gm11719	predicted gene 11719	59822	0.08
chr19_40146515_40146666	0.39	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	40696	0.11
chr11_61274046_61274219	0.38	Aldh3a2	aldehyde dehydrogenase family 3, subfamily A2	6668	0.17
chr16_4211280_4211431	0.38	Crebbp	CREB binding protein	2058	0.29
chr15_53163055_53163223	0.38	Ext1	exostosin glycosyltransferase 1	33116	0.24
chr5_123851097_123851267	0.38	Hcar2	hydroxycarboxylic acid receptor 2	14317	0.13
chr13_66949557_66949708	0.37	Ptdss1	phosphatidylserine synthase 1	4309	0.12
chr9_25795226_25795396	0.37	Gm48337	predicted gene, 48337	16436	0.17
chr19_37077879_37078030	0.36	Gm22714	predicted gene, 22714	71208	0.08
chr1_67233878_67234117	0.36	Gm15668	predicted gene 15668	15203	0.21
chr17_4479666_4479822	0.36	4930517M08Rik	RIKEN cDNA 4930517M08 gene	155234	0.04
chr11_16808080_16808304	0.36	Egfros	epidermal growth factor receptor, opposite strand	22510	0.19
chr18_53860444_53860644	0.36	Csnk1g3	casein kinase 1, gamma 3	1578	0.52
chr5_51039736_51040095	0.36	Gm40319	predicted gene, 40319	12466	0.29
chr15_9602541_9602716	0.35	Il7r	interleukin 7 receptor	72452	0.11
chr1_66839875_66840046	0.35	Gm15793	predicted gene 15793	9642	0.08
chr3_148813708_148813859	0.35	Adgrl2	adhesion G protein-coupled receptor L2	9196	0.3
chr13_22189476_22189663	0.35	Vmn1r192	vomeronasal 1 receptor 192	1429	0.18
chr8_48535922_48536090	0.34	Tenm3	teneurin transmembrane protein 3	19307	0.27
chr6_28891682_28891856	0.33	Snd1	staphylococcal nuclease and tudor domain containing 1	11726	0.21
chr6_140059358_140059541	0.33	Gm44156	predicted gene, 44156	1860	0.21
chr1_187979615_187979766	0.33	Esrrg	estrogen-related receptor gamma	18137	0.23
chr16_43345942_43346096	0.33	Zbtb20	zinc finger and BTB domain containing 20	17029	0.16
chr17_80677275_80677429	0.33	Map4k3	mitogen-activated protein kinase kinase kinase kinase 3	26202	0.2
chr6_90434918_90435091	0.33	Cfap100	cilia and flagella associated protein 100	6207	0.12
chr7_50105985_50106173	0.33	Nell1	NEL-like 1	7769	0.32
chr13_4467812_4467987	0.32	Gm48010	predicted gene, 48010	1333	0.42
chr7_38016660_38016811	0.32	Uri1	URI1, prefoldin-like chaperone	2787	0.27
chr7_50993814_50993984	0.32	Gm21036	predicted gene, 21036	6991	0.16
chr9_7891300_7891457	0.32	Birc3	baculoviral IAP repeat-containing 3	18192	0.17
chr2_167330564_167330838	0.32	B4galt5	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5	16801	0.17
chr15_77072900_77073074	0.31	Gm24753	predicted gene, 24753	5196	0.12
chr9_113968894_113969045	0.31	Ubp1	upstream binding protein 1	256	0.9
chr14_79133487_79133687	0.31	Vwa8	von Willebrand factor A domain containing 8	10334	0.15
chr2_14216800_14216951	0.31	Mrc1	mannose receptor, C type 1	12517	0.15
chr17_47990768_47990919	0.31	Gm14871	predicted gene 14871	12729	0.14
chr19_43811537_43811693	0.31	Abcc2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	1093	0.45
chr7_118697788_118697947	0.30	Gde1	glycerophosphodiester phosphodiesterase 1	7513	0.13
chr3_84061056_84061215	0.30	Gm36981	predicted gene, 36981	2317	0.33
chr14_12070865_12071149	0.30	Ptprg	protein tyrosine phosphatase, receptor type, G	20153	0.22
chr1_23484714_23484885	0.30	Gm7784	predicted gene 7784	5260	0.27
chr19_33480626_33480777	0.29	Lipo5	lipase, member O5	7510	0.16
chrX_167880328_167880485	0.29	Frmpd4	FERM and PDZ domain containing 4	17152	0.21
chr15_3482247_3482450	0.29	Ghr	growth hormone receptor	10704	0.28
chr10_87936414_87936806	0.29	Tyms-ps	thymidylate synthase, pseudogene	30237	0.15
chr8_33950546_33950701	0.29	Rbpms	RNA binding protein gene with multiple splicing	20760	0.14
chr16_77398451_77398621	0.29	Gm21816	predicted gene, 21816	1494	0.29
chr19_29148038_29148260	0.29	Gm5518	predicted gene 5518	11969	0.14
chr17_15341574_15341736	0.29	Gm7423	predicted gene 7423	19773	0.14
chr6_51701361_51701531	0.28	Gm38811	predicted gene, 38811	9635	0.25
chr11_78567734_78567893	0.28	Nlk	nemo like kinase	1103	0.27
chr19_36606384_36606566	0.28	Hectd2	HECT domain E3 ubiquitin protein ligase 2	1308	0.49
chr9_83566163_83566322	0.28	Gm39384	predicted gene, 39384	7047	0.18
chr1_9971330_9971494	0.28	Tcf24	transcription factor 24	3480	0.12
chr4_102527232_102527683	0.28	Pde4b	phosphodiesterase 4B, cAMP specific	42638	0.2
chr19_33489637_33489788	0.28	Lipo5	lipase, member O5	16521	0.14
chr13_111295092_111295280	0.27	Actbl2	actin, beta-like 2	40173	0.13
chr3_32530121_32530289	0.27	Mfn1	mitofusin 1	666	0.62
chr3_138363372_138363558	0.27	Adh6-ps1	alcohol dehydrogenase 6 (class V), pseudogene 1	10656	0.12
chr7_49393023_49393262	0.27	Nav2	neuron navigator 2	28421	0.19
chr2_42039219_42039481	0.27	Gm13461	predicted gene 13461	50521	0.18
chr13_25083206_25083394	0.27	Dcdc2a	doublecortin domain containing 2a	13047	0.18
chr2_147873093_147873253	0.27	Gm25516	predicted gene, 25516	1705	0.48
chr11_99739497_99739661	0.27	Gm14180	predicted gene 14180	5289	0.06
chr5_90322868_90323041	0.27	Ankrd17	ankyrin repeat domain 17	16789	0.19
chr10_86350127_86350278	0.27	Timp3	tissue inhibitor of metalloproteinase 3	47348	0.13
chr18_35707850_35708033	0.27	Dnajc18	DnaJ heat shock protein family (Hsp40) member C18	441	0.67
chr10_111576009_111576338	0.27	4933440J02Rik	RIKEN cDNA 4933440J02 gene	18100	0.14
chr1_53291339_53291521	0.26	Pms1	PMS1 homolog 1, mismatch repair system component	5537	0.12
chr1_9985468_9985649	0.26	Ppp1r42	protein phosphatase 1, regulatory subunit 42	134	0.92
chr9_74801197_74801365	0.26	Gm22315	predicted gene, 22315	19211	0.16
chr5_16316197_16316406	0.26	Cacna2d1	calcium channel, voltage-dependent, alpha2/delta subunit 1	9684	0.24
chr15_62644818_62645021	0.26	Gm24810	predicted gene, 24810	8085	0.29
chr18_11858447_11858616	0.25	Cables1	CDK5 and Abl enzyme substrate 1	14231	0.16
chr1_9988282_9988979	0.25	Ppp1r42	protein phosphatase 1, regulatory subunit 42	2938	0.14
chr2_75770625_75770799	0.25	Gm13657	predicted gene 13657	6476	0.15
chr2_84357197_84357348	0.25	Calcrl	calcitonin receptor-like	18086	0.19
chr16_58663097_58663248	0.25	Cpox	coproporphyrinogen oxidase	7120	0.13
chr6_42375567_42375731	0.25	2010310C07Rik	RIKEN cDNA 2010310C07 gene	2307	0.14
chr9_122848915_122849207	0.25	Gm47140	predicted gene, 47140	643	0.55
chr4_15481608_15481775	0.25	Gm11856	predicted gene 11856	4675	0.28
chr3_107238675_107238837	0.25	Prok1	prokineticin 1	104	0.95
chr2_68890514_68890665	0.25	Gm37159	predicted gene, 37159	777	0.58
chr6_72897626_72897819	0.24	Kcmf1	potassium channel modulatory factor 1	1361	0.34
chr19_8252613_8252782	0.24	Gm41804	predicted gene, 41804	729	0.61
chr1_164426310_164426497	0.24	Gm37411	predicted gene, 37411	1690	0.31
chr3_64468587_64468748	0.24	Vmn2r-ps8	vomeronasal 2, receptor, pseudogene 8	8351	0.13
chr3_108289571_108289732	0.24	Gm43099	predicted gene 43099	1770	0.18
chr11_50175754_50175938	0.24	Mrnip	MRN complex interacting protein	939	0.42
chr5_91200748_91201014	0.24	Gm23092	predicted gene, 23092	17123	0.2
chr4_102811502_102811684	0.24	Sgip1	SH3-domain GRB2-like (endophilin) interacting protein 1	51068	0.15
chr2_134826467_134826626	0.24	Gm14036	predicted gene 14036	22597	0.2
chr3_31376198_31376349	0.24	Gm38025	predicted gene, 38025	35261	0.18
chr15_53164134_53164470	0.24	Ext1	exostosin glycosyltransferase 1	31953	0.25
chr12_69419094_69419426	0.24	Gm9887	predicted gene 9887	46792	0.08
chr4_101393290_101393478	0.24	Gm12798	predicted gene 12798	9697	0.12
chr13_63665698_63665976	0.23	Gm47387	predicted gene, 47387	4040	0.18
chr10_111171839_111171990	0.23	Osbpl8	oxysterol binding protein-like 8	7112	0.15
chr10_40246394_40246686	0.23	Rpf2	ribosome production factor 2 homolog	453	0.69
chr6_54032027_54032218	0.23	Chn2	chimerin 2	7432	0.21
chr15_81521072_81521223	0.23	Gm5218	predicted gene 5218	21602	0.11
chr7_14307656_14308010	0.23	Phf20-ps	PHD finger protein 20, pseudogene	3053	0.2
chr3_149179928_149180099	0.23	Gm42647	predicted gene 42647	30258	0.19
chr16_92076898_92077091	0.23	Slc5a3	solute carrier family 5 (inositol transporters), member 3	1068	0.38
chr19_34712180_34712357	0.23	Gm18425	predicted gene, 18425	2260	0.22
chr16_70331211_70331434	0.23	Gbe1	glucan (1,4-alpha-), branching enzyme 1	17188	0.24
chr6_53521285_53521560	0.22	Creb5	cAMP responsive element binding protein 5	51878	0.15
chr2_42022610_42022815	0.22	Gm13461	predicted gene 13461	33883	0.23
chr6_8429968_8430158	0.22	Umad1	UMAP1-MVP12 associated (UMA) domain containing 1	10385	0.16
chr7_80789186_80789337	0.22	Iqgap1	IQ motif containing GTPase activating protein 1	14002	0.16
chr10_121349498_121349682	0.22	Gm48435	predicted gene, 48435	870	0.44
chr11_16912365_16912516	0.22	Egfr	epidermal growth factor receptor	7255	0.19
chr1_73684327_73684549	0.22	6030407O03Rik	RIKEN cDNA 6030407O03 gene	59509	0.12
chr3_18157205_18157356	0.22	Gm23686	predicted gene, 23686	20345	0.21
chr15_38914094_38914399	0.22	Baalc	brain and acute leukemia, cytoplasmic	18898	0.16
chr11_16863303_16863761	0.22	Egfr	epidermal growth factor receptor	14618	0.19
chr1_67228479_67228681	0.22	Gm15668	predicted gene 15668	20620	0.2
chr17_86647655_86647806	0.21	Gm18832	predicted gene, 18832	37766	0.16
chr1_75337875_75338132	0.21	Dnpep	aspartyl aminopeptidase	20013	0.09
chr3_18148711_18148862	0.21	Gm23686	predicted gene, 23686	28839	0.19
chr7_112688480_112688662	0.21	Tead1	TEA domain family member 1	3127	0.21
chr17_65788655_65788828	0.21	Ppp4r1	protein phosphatase 4, regulatory subunit 1	5142	0.19
chr6_111600197_111600355	0.21	Gm22093	predicted gene, 22093	2976	0.4
chr3_18148886_18149070	0.21	Gm23686	predicted gene, 23686	28647	0.19
chr3_27905130_27905320	0.21	Tmem212	transmembrane protein 212	8857	0.22
chr4_130704823_130704974	0.21	Pum1	pumilio RNA-binding family member 1	41492	0.1
chr1_184053978_184054158	0.21	Dusp10	dual specificity phosphatase 10	19687	0.21
chr13_80887789_80888455	0.21	Arrdc3	arrestin domain containing 3	1982	0.27
chr1_71723871_71724224	0.21	Gm5256	predicted gene 5256	9123	0.19
chr14_26432359_26432703	0.21	Slmap	sarcolemma associated protein	2430	0.24
chr5_74833941_74834092	0.21	Gm17906	predicted gene, 17906	49319	0.12
chr10_81388466_81388771	0.21	Gm48552	predicted gene, 48552	387	0.55
chr3_130409662_130410071	0.21	Col25a1	collagen, type XXV, alpha 1	68950	0.11
chr1_184100523_184100685	0.21	Dusp10	dual specificity phosphatase 10	66223	0.12
chr4_99068687_99068838	0.21	Dock7	dedicator of cytokinesis 7	1651	0.35
chr16_56038236_56038391	0.21	Trmt10c	tRNA methyltransferase 10C, mitochondrial RNase P subunit	494	0.65
chr11_5306963_5307114	0.20	Gm30172	predicted gene, 30172	32953	0.14
chr14_30184944_30185295	0.20	Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	9728	0.2
chr1_185216852_185217011	0.20	Rab3gap2	RAB3 GTPase activating protein subunit 2	12753	0.13
chr13_34465973_34466145	0.20	Gm47120	predicted gene, 47120	39628	0.12
chr1_43935708_43935875	0.20	Tpp2	tripeptidyl peptidase II	1746	0.27
chr7_28927529_28927703	0.20	Actn4	actinin alpha 4	8395	0.1
chr5_90520250_90520471	0.20	Afm	afamin	1411	0.31
chr9_7858246_7858397	0.20	Birc3	baculoviral IAP repeat-containing 3	2005	0.3
chr5_28060446_28060778	0.20	Gm26608	predicted gene, 26608	5153	0.18
chr7_145092850_145093049	0.20	Gm45181	predicted gene 45181	70047	0.1
chr1_186952519_186952695	0.20	Gm3809	predicted gene 3809	7901	0.15
chr8_80046818_80046969	0.20	Hhip	Hedgehog-interacting protein	11113	0.21
chrX_98051624_98051802	0.20	Gm14802	predicted gene 14802	11338	0.3
chr7_14438643_14438794	0.20	Sult2a8	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8	157	0.95
chr12_12510893_12511142	0.20	4921511I17Rik	RIKEN cDNA 4921511I17 gene	118402	0.06
chr11_90643436_90643587	0.20	Cox11	cytochrome c oxidase assembly protein 11, copper chaperone	3333	0.22
chr12_71399037_71399230	0.20	1700083H02Rik	RIKEN cDNA 1700083H02 gene	14925	0.18
chr1_88048809_88049389	0.20	Ugt1a10	UDP glycosyltransferase 1 family, polypeptide A10	6289	0.08
chr3_138242749_138243005	0.19	0610031O16Rik	RIKEN cDNA 0610031O16 gene	2472	0.18
chr17_47627069_47627220	0.19	Usp49	ubiquitin specific peptidase 49	3546	0.11
chr18_37825326_37825501	0.19	Gm38182	predicted gene, 38182	676	0.4
chr8_91529579_91530083	0.19	Gm45290	predicted gene 45290	2893	0.21
chr6_35253418_35253775	0.19	1810058I24Rik	RIKEN cDNA 1810058I24 gene	864	0.54
chr1_184330776_184331172	0.19	Gm37223	predicted gene, 37223	27355	0.2
chr14_36743243_36743409	0.19	Gm25204	predicted gene, 25204	24099	0.23
chr5_23562685_23562882	0.19	Srpk2	serine/arginine-rich protein specific kinase 2	13413	0.19
chr4_150434207_150434380	0.19	Rere	arginine glutamic acid dipeptide (RE) repeats	27899	0.2
chr11_87713864_87714038	0.19	1110028F11Rik	RIKEN cDNA 1110028F11 gene	11828	0.09
chr2_3415817_3416004	0.19	Meig1	meiosis expressed gene 1	2671	0.18
chr12_57444501_57444678	0.19	Gm16246	predicted gene 16246	5531	0.24
chr13_36053796_36053967	0.19	Gm48770	predicted gene, 48770	58428	0.08
chr1_7096771_7096931	0.19	Pcmtd1	protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1	7685	0.17
chr3_4950385_4950550	0.19	Gm6140	predicted gene 6140	59236	0.14
chr9_107674673_107674872	0.19	Gnat1	guanine nucleotide binding protein, alpha transducing 1	1669	0.18
chr13_9145204_9145368	0.19	Gm28155	predicted gene 28155	4405	0.19
chr4_82404190_82404364	0.19	n-R5s188	nuclear encoded rRNA 5S 188	35133	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxb1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.1	0.2	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.1	GO:2000598	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.0	0.1	GO:0046292	formaldehyde metabolic process(GO:0046292)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.1	GO:2000138	positive regulation of cell proliferation involved in heart morphogenesis(GO:2000138)
0.0	0.1	GO:2000860	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0	0.1	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.1	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.1	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.2	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.0	0.0	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0006559	L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.1	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.1	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0	0.1	GO:0010159	specification of organ position(GO:0010159)
0.0	0.1	GO:0000957	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.2	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	0.1	GO:0090043	regulation of tubulin deacetylation(GO:0090043)
0.0	0.2	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.2	GO:0097264	self proteolysis(GO:0097264)
0.0	0.1	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0	0.1	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.0	GO:0039533	regulation of MDA-5 signaling pathway(GO:0039533) negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0	0.0	GO:0090170	regulation of Golgi inheritance(GO:0090170)
0.0	0.1	GO:1902534	single-organism membrane invagination(GO:1902534)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.2	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0061010	gall bladder development(GO:0061010)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:0015766	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.2	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	0.0	GO:0006069	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.1	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.0	0.1	GO:1903551	regulation of extracellular exosome assembly(GO:1903551)
0.0	0.0	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.0	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.0	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.4	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0097340	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0	0.0	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0	0.0	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.1	GO:0070671	response to interleukin-12(GO:0070671)
0.0	0.0	GO:0071288	cellular response to mercury ion(GO:0071288)
0.0	0.0	GO:0032377	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.0	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.0	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0	0.1	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
0.0	0.0	GO:0090365	regulation of mRNA modification(GO:0090365)
0.0	0.0	GO:0051081	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:0071638	negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0	0.1	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0	0.0	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.1	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.0	GO:0006868	glutamine transport(GO:0006868)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:2000973	regulation of pro-B cell differentiation(GO:2000973)
0.0	0.0	GO:1902947	regulation of tau-protein kinase activity(GO:1902947)
0.0	0.0	GO:0044598	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.0	GO:0015819	lysine transport(GO:0015819)
0.0	0.0	GO:1904684	negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
0.0	0.0	GO:0003383	apical constriction(GO:0003383)
0.0	0.0	GO:0021986	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0	0.0	GO:0002752	cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0	0.0	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0	0.1	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	0.0	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.0	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.1	GO:0019856	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.0	GO:0072592	oxygen metabolic process(GO:0072592)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:0035166	post-embryonic hemopoiesis(GO:0035166)
0.0	0.0	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.0	GO:0000710	meiotic mismatch repair(GO:0000710)
0.0	0.1	GO:0008300	isoprenoid catabolic process(GO:0008300)
0.0	0.0	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.0	GO:0071798	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	0.1	GO:0009109	coenzyme catabolic process(GO:0009109)
0.0	0.2	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.1	GO:0015791	polyol transport(GO:0015791)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.0	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:1902969	mitotic DNA replication(GO:1902969)
0.0	0.0	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.1	GO:0042977	activation of JAK2 kinase activity(GO:0042977)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.3	GO:0002177	manchette(GO:0002177)
0.0	0.2	GO:0097433	dense body(GO:0097433)
0.0	0.2	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0000811	GINS complex(GO:0000811)
0.0	0.2	GO:0000153	cytoplasmic ubiquitin ligase complex(GO:0000153)
0.0	0.0	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.0	0.1	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.2	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.0	GO:1990696	USH2 complex(GO:1990696)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.0	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0071598	neuronal ribonucleoprotein granule(GO:0071598)
0.0	0.0	GO:1990423	RZZ complex(GO:1990423)
0.0	0.0	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	0.0	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.2	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.2	GO:0030014	CCR4-NOT complex(GO:0030014)
0.0	0.0	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.2	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.2	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.2	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.1	GO:0031433	telethonin binding(GO:0031433)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.2	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0008240	tripeptidyl-peptidase activity(GO:0008240)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.2	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0015157	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.0	GO:0097108	hedgehog family protein binding(GO:0097108)
0.0	0.0	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.0	GO:0035276	ethanol binding(GO:0035276)
0.0	0.0	GO:0015119	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.0	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.2	GO:0031690	adrenergic receptor binding(GO:0031690)
0.0	0.0	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.0	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.0	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.0	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0	0.1	GO:0015189	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0	0.0	GO:0005030	neurotrophin receptor activity(GO:0005030)
0.0	0.1	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.0	0.0	GO:0032142	single guanine insertion binding(GO:0032142)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.0	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.0	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.0	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.0	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.1	GO:0005351	sugar:proton symporter activity(GO:0005351)
0.0	0.0	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID ERBB4 PATHWAY	ErbB4 signaling events
0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.4	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.2	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.1	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism