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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Foxn1

Z-value: 1.05

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Transcription factors associated with Foxn1

Gene Symbol	Gene ID	Gene Info
Foxn1 Ensembl NCBI MGI UniProt	ENSMUSG00000002057.4	Foxn1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Foxn1	chr11_78372687_78372853	13788	0.087005	0.26	6.1e-01	Click!
Foxn1	chr11_78372975_78373151	13495	0.087385	0.22	6.8e-01	Click!

Activity of the Foxn1 motif across conditions

Conditions sorted by the z-value of the Foxn1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr14_51089937_51090106	0.89	Rnase4	ribonuclease, RNase A family 4	1056	0.24
chr8_11249894_11250051	0.64	Col4a1	collagen, type IV, alpha 1	4367	0.21
chr7_48930338_48930500	0.62	Gm18559	predicted gene, 18559	9699	0.14
chr2_72179596_72179778	0.57	Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4	6	0.98
chr14_52279190_52279559	0.56	Rab2b	RAB2B, member RAS oncogene family	35	0.68
chr5_113142564_113142931	0.53	4930557B06Rik	RIKEN cDNA 4930557B06 gene	298	0.81
chr10_40302183_40302345	0.53	Amd1	S-adenosylmethionine decarboxylase 1	76	0.95
chr9_43636478_43636893	0.49	Gm29961	predicted gene, 29961	7393	0.18
chr1_171281170_171281333	0.47	Ppox	protoporphyrinogen oxidase	65	0.91
chr9_63201496_63201967	0.44	Skor1	SKI family transcriptional corepressor 1	52770	0.12
chr2_148522150_148522301	0.43	Gm14120	predicted gene 14120	53335	0.11
chr1_157008781_157008932	0.41	Gm10531	predicted gene 10531	34691	0.13
chr9_104161174_104161357	0.40	Dnajc13	DnaJ heat shock protein family (Hsp40) member C13	656	0.61
chr1_180161597_180161764	0.40	Cdc42bpa	CDC42 binding protein kinase alpha	673	0.64
chr6_128803059_128803375	0.40	Klrb1c	killer cell lectin-like receptor subfamily B member 1C	14002	0.09
chr11_109670186_109670371	0.40	Prkar1a	protein kinase, cAMP dependent regulatory, type I, alpha	4334	0.19
chr19_27429919_27430086	0.38	Pum3	pumilio RNA-binding family member 3	177	0.96
chr2_110229824_110230205	0.35	Gm22997	predicted gene, 22997	12011	0.18
chr17_30609874_30610226	0.35	Glo1	glyoxalase 1	2519	0.15
chr8_121071062_121071213	0.34	Fendrr	Foxf1 adjacent non-coding developmental regulatory RNA	10724	0.12
chr15_54924268_54924437	0.34	Enpp2	ectonucleotide pyrophosphatase/phosphodiesterase 2	1739	0.36
chr13_113589653_113589822	0.34	Gm34471	predicted gene, 34471	21970	0.15
chr13_54622139_54622505	0.33	Faf2	Fas associated factor family member 2	484	0.69
chr3_104639553_104639867	0.33	Slc16a1	solute carrier family 16 (monocarboxylic acid transporters), member 1	1042	0.32
chr13_40890430_40890581	0.32	Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	3312	0.14
chr14_54603440_54603604	0.32	4931414P19Rik	RIKEN cDNA 4931414P19 gene	2471	0.12
chr10_13553038_13553200	0.32	Pex3	peroxisomal biogenesis factor 3	1	0.75
chr19_6242419_6242590	0.31	Atg2a	autophagy related 2A	836	0.36
chr2_29124935_29125101	0.31	Setx	senataxin	26	0.97
chr16_30965341_30965552	0.30	Gm15742	predicted gene 15742	8072	0.18
chrX_12134649_12134805	0.30	Bcor	BCL6 interacting corepressor	6327	0.27
chr10_18065992_18066156	0.30	Reps1	RalBP1 associated Eps domain containing protein	10070	0.2
chr7_35396851_35397006	0.30	Faap24	Fanconi anemia core complex associated protein 24	92	0.51
chr4_132040365_132040540	0.29	Gm13063	predicted gene 13063	7726	0.12
chr1_93123310_93123471	0.29	Gm28086	predicted gene 28086	713	0.57
chr10_99576469_99576639	0.29	Gm20110	predicted gene, 20110	32617	0.14
chr2_19658586_19658737	0.28	Otud1	OTU domain containing 1	909	0.47
chr7_28831672_28831952	0.28	Ech1	enoyl coenzyme A hydratase 1, peroxisomal	561	0.52
chr13_14063374_14063726	0.27	Ggps1	geranylgeranyl diphosphate synthase 1	62	0.72
chr7_80088340_80088502	0.27	Gm44949	predicted gene 44949	2010	0.2
chr11_100738407_100738714	0.27	Rab5c	RAB5C, member RAS oncogene family	345	0.76
chr9_24420197_24420363	0.27	Dpy19l1	dpy-19-like 1 (C. elegans)	3679	0.27
chr3_89418996_89419160	0.26	Shc1	src homology 2 domain-containing transforming protein C1	464	0.47
chr1_75253990_75254151	0.26	Gm28294	predicted gene 28294	1748	0.15
chr11_98982083_98982254	0.26	Gjd3	gap junction protein, delta 3	848	0.44
chr8_22335552_22335714	0.26	Tpte	transmembrane phosphatase with tensin homology	52192	0.08
chr9_29750692_29750843	0.26	Gm15521	predicted gene 15521	158257	0.04
chr12_25235200_25235794	0.26	Gm19340	predicted gene, 19340	47098	0.12
chr8_126527053_126527635	0.25	Gm26759	predicted gene, 26759	39626	0.14
chr1_23187785_23188477	0.24	Gm29506	predicted gene 29506	47542	0.11
chr13_58067763_58068069	0.24	Klhl3	kelch-like 3	34512	0.13
chr5_53992615_53992786	0.24	Stim2	stromal interaction molecule 2	5799	0.26
chr6_134792589_134792746	0.23	Dusp16	dual specificity phosphatase 16	42	0.97
chr5_117417582_117417750	0.23	Ksr2	kinase suppressor of ras 2	3666	0.18
chr4_107002389_107002540	0.23	Gm12786	predicted gene 12786	20035	0.15
chr15_97019476_97019938	0.23	Slc38a4	solute carrier family 38, member 4	244	0.95
chr1_193288543_193288694	0.23	Gm37650	predicted gene, 37650	2271	0.18
chr12_102748209_102748378	0.23	Tmem251	transmembrane protein 251	4531	0.09
chr19_38089508_38089672	0.23	Ffar4	free fatty acid receptor 4	7481	0.14
chr7_80653838_80654052	0.23	Gm15880	predicted gene 15880	17928	0.15
chr11_120340498_120340661	0.22	Gm23419	predicted gene, 23419	6240	0.09
chr10_83347610_83347786	0.22	Gm40723	predicted gene, 40723	3185	0.21
chr5_130171601_130171776	0.22	Rabgef1	RAB guanine nucleotide exchange factor (GEF) 1	110	0.94
chr8_119435449_119435786	0.22	Osgin1	oxidative stress induced growth inhibitor 1	1493	0.34
chr10_17722281_17722461	0.22	Cited2	Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2	847	0.66
chr18_68499103_68499266	0.21	Gm29677	predicted gene, 29677	60238	0.1
chr11_6335474_6335637	0.21	Ogdh	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)	42950	0.08
chr10_81551987_81552144	0.21	Gna11	guanine nucleotide binding protein, alpha 11	6875	0.07
chr9_37147174_37147330	0.21	Pknox2	Pbx/knotted 1 homeobox 2	14	0.96
chr9_124424931_124425085	0.21	Ppp2r3d	protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta	854	0.55
chr11_100808840_100809039	0.20	Stat5b	signal transducer and activator of transcription 5B	13589	0.12
chr7_28437107_28437270	0.20	Gmfg	glia maturation factor, gamma	259	0.76
chr4_132946310_132946569	0.20	Gm24913	predicted gene, 24913	15122	0.13
chr8_66486485_66486874	0.20	Tma16	translation machinery associated 16	149	0.95
chr10_66909327_66909486	0.20	1110002J07Rik	RIKEN cDNA 1110002J07 gene	8333	0.16
chr1_74124750_74124964	0.19	Tns1	tensin 1	408	0.62
chr14_79482321_79482598	0.19	Wbp4	WW domain binding protein 4	939	0.41
chr2_94162272_94162444	0.19	Hsd17b12	hydroxysteroid (17-beta) dehydrogenase 12	4394	0.19
chr13_14064834_14065347	0.19	Arid4b	AT rich interactive domain 4B (RBP1-like)	267	0.84
chr6_93876489_93876704	0.19	Gm22840	predicted gene, 22840	14019	0.23
chr15_31344240_31344565	0.18	Ankrd33b	ankyrin repeat domain 33B	19153	0.14
chr4_84069800_84069979	0.18	6030471H07Rik	RIKEN cDNA 6030471H07 gene	25010	0.19
chr4_152302091_152302261	0.18	Icmt	isoprenylcysteine carboxyl methyltransferase	3211	0.14
chr11_98740713_98740882	0.18	Thra	thyroid hormone receptor alpha	4	0.95
chr19_41388446_41388602	0.18	Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	3422	0.3
chr7_12950233_12950384	0.18	1810019N24Rik	RIKEN cDNA 1810019N24 gene	242	0.81
chr9_96758999_96759348	0.17	Zbtb38	zinc finger and BTB domain containing 38	6342	0.16
chr17_29323723_29323898	0.17	Gm46603	predicted gene, 46603	1261	0.28
chr3_105825808_105826159	0.17	Gm5547	predicted gene 5547	9370	0.12
chr13_52828377_52828538	0.17	BB123696	expressed sequence BB123696	71252	0.11
chr14_114854717_114854875	0.17	Gm49010	predicted gene, 49010	21714	0.15
chr3_105053004_105053165	0.17	Cttnbp2nl	CTTNBP2 N-terminal like	62	0.97
chr3_95928829_95929106	0.17	Anp32e	acidic (leucine-rich) nuclear phosphoprotein 32 family, member E	279	0.81
chr10_117497904_117498070	0.17	Gm32141	predicted gene, 32141	50494	0.09
chr14_62556439_62556816	0.17	Fam124a	family with sequence similarity 124, member A	852	0.48
chr17_26123354_26123516	0.17	Mrpl28	mitochondrial ribosomal protein L28	65	0.93
chr9_58582606_58582757	0.16	Nptn	neuroplastin	237	0.92
chr8_11173356_11173731	0.16	Gm15418	predicted gene 15418	14212	0.15
chr2_132110806_132111002	0.16	Slc23a2	solute carrier family 23 (nucleobase transporters), member 2	544	0.75
chr16_55698500_55698846	0.16	Gm19771	predicted gene, 19771	41245	0.16
chr3_79218581_79218770	0.16	4921511C10Rik	RIKEN cDNA 4921511C10 gene	5756	0.2
chr15_100121547_100121719	0.16	4930478M13Rik	RIKEN cDNA 4930478M13 gene	13472	0.14
chr4_132515539_132515706	0.16	Sesn2	sestrin 2	5121	0.1
chr19_47438467_47438632	0.16	Sh3pxd2a	SH3 and PX domains 2A	25698	0.17
chr17_35918919_35919191	0.16	Mir1894	microRNA 1894	1166	0.17
chr1_57429882_57430054	0.16	Gm22371	predicted gene, 22371	7595	0.15
chr5_96917597_96917811	0.16	Gm8013	predicted gene 8013	3568	0.12
chr2_131222260_131222415	0.16	Mavs	mitochondrial antiviral signaling protein	11726	0.1
chr1_72288908_72289079	0.16	Tmem169	transmembrane protein 169	4598	0.15
chr12_80247162_80247339	0.16	Actn1	actinin, alpha 1	11534	0.15
chr11_31671872_31672045	0.16	Bod1	biorientation of chromosomes in cell division 1	73	0.98
chr10_79936936_79937107	0.16	Arid3a	AT rich interactive domain 3A (BRIGHT-like)	6597	0.06
chr7_70549056_70549216	0.16	Gm35842	predicted gene, 35842	267	0.88
chr7_141581336_141581865	0.16	Ap2a2	adaptor-related protein complex 2, alpha 2 subunit	19070	0.1
chr10_8844879_8845170	0.16	4930553I21Rik	RIKEN cDNA 4930553I21 gene	16419	0.15
chr3_146450379_146450546	0.16	Ctbs	chitobiase	8	0.97
chr17_28930498_28930665	0.15	Gm16191	predicted gene 16191	3840	0.1
chr16_86816748_86816918	0.15	Gm32624	predicted gene, 32624	33	0.98
chr8_106278256_106278407	0.15	Smpd3	sphingomyelin phosphodiesterase 3, neutral	2647	0.22
chr11_54539316_54539467	0.15	Rapgef6	Rap guanine nucleotide exchange factor (GEF) 6	16445	0.19
chr7_24972671_24972836	0.15	Rabac1	Rab acceptor 1 (prenylated)	1	0.95
chr9_69273022_69273200	0.15	Rora	RAR-related orphan receptor alpha	16571	0.24
chr1_55088026_55088196	0.15	Hspe1	heat shock protein 1 (chaperonin 10)	21	0.55
chr13_81783090_81783247	0.15	Cetn3	centrin 3	91	0.9
chr15_27919308_27919503	0.15	Trio	triple functional domain (PTPRF interacting)	134	0.97
chr15_90215048_90215209	0.15	Alg10b	asparagine-linked glycosylation 10B (alpha-1,2-glucosyltransferase)	9183	0.22
chr9_70207215_70207378	0.15	Myo1e	myosin IE	54	0.98
chr14_46615984_46616316	0.15	Gm49319	predicted gene, 49319	5140	0.13
chr5_145191503_145191838	0.15	Atp5j2	ATP synthase, H+ transporting, mitochondrial F0 complex, subunit F2	78	0.94
chr16_97357218_97357390	0.15	Bace2	beta-site APP-cleaving enzyme 2	562	0.8
chr9_99568726_99568886	0.15	Armc8	armadillo repeat containing 8	93	0.96
chr15_95897769_95897945	0.15	Gm25070	predicted gene, 25070	18040	0.17
chr10_93523037_93523409	0.14	Amdhd1	amidohydrolase domain containing 1	16810	0.12
chr4_123718182_123718341	0.14	Ndufs5	NADH:ubiquinone oxidoreductase core subunit S5	59	0.96
chr19_8920279_8920446	0.14	B3gat3	beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)	12	0.91
chr11_116103660_116103816	0.14	Trim47	tripartite motif-containing 47	3345	0.12
chrX_7841056_7841418	0.14	Otud5	OTU domain containing 5	127	0.91
chr14_65033978_65034138	0.14	Extl3	exostosin-like glycosyltransferase 3	64047	0.09
chr16_14158957_14159171	0.14	Marf1	meiosis regulator and mRNA stability 1	203	0.78
chr18_65490248_65490399	0.14	Gm50246	predicted gene, 50246	11083	0.13
chr9_110871597_110871767	0.14	Tmie	transmembrane inner ear	4339	0.1
chr9_63611147_63611298	0.14	Aagab	alpha- and gamma-adaptin binding protein	5766	0.2
chr18_9957685_9957884	0.14	Thoc1	THO complex 1	122	0.96
chr8_106936076_106936231	0.14	Sntb2	syntrophin, basic 2	4	0.96
chr6_85451857_85452015	0.14	Pradc1	protease-associated domain containing 1	9	0.55
chr16_26105727_26105925	0.14	P3h2	prolyl 3-hydroxylase 2	42	0.99
chr6_54593211_54593386	0.14	Fkbp14	FK506 binding protein 14	121	0.95
chr11_69671384_69671748	0.14	Eif4a1	eukaryotic translation initiation factor 4A1	116	0.83
chr6_113483178_113483358	0.14	Creld1	cysteine-rich with EGF-like domains 1	29	0.94
chr2_135711190_135711341	0.14	Gm14211	predicted gene 14211	18111	0.18
chr9_62040306_62040468	0.13	Paqr5	progestin and adipoQ receptor family member V	13531	0.2
chr13_34054480_34054653	0.13	Bphl	biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)	5361	0.12
chr8_121108318_121108477	0.13	Mthfsd	methenyltetrahydrofolate synthetase domain containing	5	0.96
chr5_90366520_90366679	0.13	Gm9958	predicted gene 9958	21	0.5
chr9_48819032_48819183	0.13	Zbtb16	zinc finger and BTB domain containing 16	16838	0.22
chr14_25458404_25458994	0.13	Zmiz1	zinc finger, MIZ-type containing 1	486	0.55
chr2_167834679_167834867	0.13	1200007C13Rik	RIKEN cDNA 1200007C13 gene	1127	0.46
chr9_124424253_124424419	0.13	Ppp2r3d	protein phosphatase 2 (formerly 2A), regulatory subunit B'', delta	182	0.93
chr9_111156088_111156255	0.13	Lrrfip2	leucine rich repeat (in FLII) interacting protein 2	5132	0.2
chr2_30124472_30124630	0.12	Zer1	zyg-11 related, cell cycle regulator	28	0.95
chr17_10040936_10041349	0.12	Gm49809	predicted gene, 49809	93305	0.08
chr18_10532849_10533008	0.12	Gm24894	predicted gene, 24894	18478	0.16
chr18_39491582_39491748	0.12	Nr3c1	nuclear receptor subfamily 3, group C, member 1	364	0.91
chr17_86662584_86662735	0.12	Gm18832	predicted gene, 18832	22837	0.19
chr12_110446883_110447049	0.12	Ppp2r5c	protein phosphatase 2, regulatory subunit B', gamma	154	0.95
chr3_83286962_83287132	0.12	Gm38096	predicted gene, 38096	116355	0.06
chr18_21300026_21300190	0.12	Garem1	GRB2 associated regulator of MAPK1 subtype 1	15	0.97
chr17_26561346_26561508	0.12	Ergic1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	62	0.5
chr2_125859018_125859178	0.12	Galk2	galactokinase 2	11	0.51
chr17_45619482_45619671	0.12	Gm25008	predicted gene, 25008	1103	0.32
chr1_72641063_72641244	0.12	Gm39662	predicted gene, 39662	35	0.97
chr5_150611809_150611960	0.12	Gm43597	predicted gene 43597	4881	0.11
chr6_94813223_94813696	0.12	Gm7833	predicted gene 7833	7071	0.15
chr10_80433895_80434247	0.12	Tcf3	transcription factor 3	424	0.68
chr2_90579423_90579643	0.12	Ptprj	protein tyrosine phosphatase, receptor type, J	1114	0.56
chr14_52019661_52019820	0.12	Zfp219	zinc finger protein 219	27	0.81
chr12_111574326_111574506	0.12	2810029C07Rik	RIKEN cDNA 2810029C07 gene	14	0.59
chr8_108744763_108744935	0.12	Gm38042	predicted gene, 38042	7256	0.25
chr11_115433171_115433606	0.12	Kctd2	potassium channel tetramerisation domain containing 2	4035	0.09
chr13_32338696_32338889	0.12	A730091E23Rik	RIKEN cDNA A730091E23 gene	27	0.52
chr11_101646100_101646269	0.12	Gm23971	predicted gene, 23971	254	0.82
chr14_55660395_55660554	0.11	Mdp1	magnesium-dependent phosphatase 1	23	0.9
chr19_24225064_24225259	0.11	Tjp2	tight junction protein 2	131	0.96
chr13_113509396_113509559	0.11	4921509O07Rik	RIKEN cDNA 4921509O07 gene	6633	0.17
chr5_86172820_86173003	0.11	Uba6	ubiquitin-like modifier activating enzyme 6	108	0.97
chrX_101222593_101222760	0.11	Snx12	sorting nexin 12	113	0.94
chr5_38483324_38483475	0.11	Slc2a9	solute carrier family 2 (facilitated glucose transporter), member 9	14	0.98
chr2_181599163_181599377	0.11	Samd10	sterile alpha motif domain containing 10	58	0.93
chr14_61556616_61556767	0.11	Spryd7	SPRY domain containing 7	67	0.94
chr10_68274977_68275295	0.11	Arid5b	AT rich interactive domain 5B (MRF1-like)	3585	0.28
chr4_138304765_138304921	0.11	Ddost	dolichyl-di-phosphooligosaccharide-protein glycotransferase	113	0.94
chr7_140999352_140999505	0.11	Gm7514	predicted gene 7514	5915	0.08
chr1_90603338_90603497	0.11	Cops8	COP9 signalosome subunit 8	59	0.98
chr5_114461138_114461289	0.11	Mvk	mevalonate kinase	8793	0.15
chr3_51483949_51484322	0.11	Rab33b	RAB33B, member RAS oncogene family	169	0.83
chr14_14012284_14012666	0.11	Atxn7	ataxin 7	16	0.98
chr8_84976570_84976736	0.11	AC163703.1		111	0.88
chr16_85803386_85803666	0.11	Adamts1	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1	413	0.88
chr19_9989208_9989752	0.11	Best1	bestrophin 1	3435	0.13
chr16_78301611_78301777	0.11	Cxadr	coxsackie virus and adenovirus receptor	62	0.93

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxn1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0006597	spermine biosynthetic process(GO:0006597)
0.1	0.3	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.1	0.4	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.1	0.2	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.1	0.5	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.1	0.3	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.1	0.2	GO:0036215	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.1	0.2	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.1	0.2	GO:0008050	female courtship behavior(GO:0008050)
0.1	0.2	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.1	0.2	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.0	0.2	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.1	GO:0048296	isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.0	0.2	GO:0051126	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0	0.1	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.0	0.2	GO:0048227	plasma membrane to endosome transport(GO:0048227)
0.0	0.1	GO:0002840	T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840)
0.0	0.1	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.1	GO:0045054	constitutive secretory pathway(GO:0045054)
0.0	0.1	GO:0072015	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.1	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847) negative regulation of bone development(GO:1903011)
0.0	0.1	GO:0010387	COP9 signalosome assembly(GO:0010387)
0.0	0.1	GO:0050651	dermatan sulfate proteoglycan biosynthetic process(GO:0050651)
0.0	0.1	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.1	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.2	GO:0061304	retinal blood vessel morphogenesis(GO:0061304)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.1	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.0	0.3	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0021764	amygdala development(GO:0021764)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0051572	negative regulation of histone H3-K4 methylation(GO:0051572)
0.0	0.1	GO:0012502	induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.3	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0	0.2	GO:0009313	oligosaccharide catabolic process(GO:0009313)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:0015919	peroxisomal membrane transport(GO:0015919) protein import into peroxisome membrane(GO:0045046)
0.0	0.1	GO:0002326	B cell lineage commitment(GO:0002326)
0.0	0.1	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
0.0	0.1	GO:0018406	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.0	GO:0046122	purine deoxyribonucleoside metabolic process(GO:0046122)
0.0	0.0	GO:0034093	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.0	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.0	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.0	GO:0046544	development of secondary male sexual characteristics(GO:0046544)
0.0	0.0	GO:0048371	lateral mesoderm morphogenesis(GO:0048369) lateral mesoderm formation(GO:0048370) lateral mesodermal cell differentiation(GO:0048371)
0.0	0.0	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.2	GO:0010257	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.1	GO:0046415	urate metabolic process(GO:0046415)
0.0	0.0	GO:0003278	apoptotic process involved in heart morphogenesis(GO:0003278)
0.0	0.0	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.0	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.2	GO:0044804	nucleophagy(GO:0044804)
0.0	0.0	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0018230	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0	0.1	GO:0051596	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0060347	heart trabecula formation(GO:0060347)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.0	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0044316	cone cell pedicle(GO:0044316)
0.1	0.2	GO:0071203	WASH complex(GO:0071203)
0.0	0.2	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.2	GO:0098645	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.2	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.4	GO:0031305	integral component of mitochondrial inner membrane(GO:0031305)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.1	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.3	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.1	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.1	GO:0005796	Golgi lumen(GO:0005796)
0.0	0.1	GO:0097539	ciliary transition fiber(GO:0097539)
0.0	0.2	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.2	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0016272	prefoldin complex(GO:0016272)
0.0	0.1	GO:0000788	nuclear nucleosome(GO:0000788)
0.0	0.0	GO:0072487	MSL complex(GO:0072487)
0.0	0.1	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0	0.0	GO:0005642	annulate lamellae(GO:0005642)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0019808	polyamine binding(GO:0019808)
0.1	0.2	GO:0043918	4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.0	0.4	GO:0016634	oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.0	0.1	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.1	GO:0015018	galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity(GO:0015018)
0.0	0.2	GO:0035473	lipase binding(GO:0035473)
0.0	0.1	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.0	0.3	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.6	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.0	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0071253	connexin binding(GO:0071253)
0.0	0.1	GO:0043723	N-cyclopropylmelamine deaminase activity(GO:0034547) N-cyclopropylammeline deaminase activity(GO:0034548) N-cyclopropylammelide alkylamino hydrolase activity(GO:0034549) 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity(GO:0043723) tRNA-specific adenosine-37 deaminase activity(GO:0043829) archaeal-specific GTP cyclohydrolase activity(GO:0044682) tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.2	GO:0004568	chitinase activity(GO:0004568)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.0	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.0	GO:0023029	MHC class Ib protein binding(GO:0023029)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.0	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.0	GO:0043842	Kdo transferase activity(GO:0043842)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.0	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.1	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.0	GO:0019136	deoxynucleoside kinase activity(GO:0019136)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.6	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.5	REACTOME METABOLISM OF POLYAMINES	Genes involved in Metabolism of polyamines
0.5	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.1	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling