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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for Foxo3

Z-value: 1.23

Motif logo

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Transcription factors associated with Foxo3

Gene Symbol Gene ID Gene Info
Foxo3
ENSMUSG00000048756.5 forkhead box O3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr10_42271116_42271452Foxo354120.273623-0.953.1e-03Click!
chr10_42226224_42226388Foxo3320600.2039150.954.0e-03Click!
chr10_42251679_42251844Foxo366050.273648-0.946.1e-03Click!
chr10_42211682_42211846Foxo3466020.162786-0.936.5e-03Click!
chr10_42233360_42233752Foxo3248100.224152-0.937.4e-03Click!

Activity of the Foxo3 motif across conditions

Conditions sorted by the z-value of the Foxo3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr17_25648898_25649067 1.00 Gm22645
 predicted gene, 22645
 45238
 0.05
chr5_27411249_27411405 0.84 Speer4b
 spermatogenesis associated glutamate (E)-rich protein 4B
 90035
 0.09
chr1_184330776_184331172 0.78 Gm37223
 predicted gene, 37223
 27355
 0.2
chr13_37468607_37468985 0.76 Gm47731
 predicted gene, 47731
 3242
 0.13
chr3_69778568_69778734 0.71 Nmd3
 NMD3 ribosome export adaptor
 32219
 0.16
chr2_158153808_158154000 0.70 Tgm2
 transglutaminase 2, C polypeptide
 7468
 0.16
chr12_71430131_71430651 0.66 1700083H02Rik
 RIKEN cDNA 1700083H02 gene
 46183
 0.12
chr19_6041292_6041476 0.64 Gm8034
 predicted gene 8034
 3438
 0.07
chr2_25363590_25363748 0.62 Uap1l1
 UDP-N-acteylglucosamine pyrophosphorylase 1-like 1
 29
 0.93
chr5_8962552_8962757 0.60 Abcb4
 ATP-binding cassette, sub-family B (MDR/TAP), member 4
 4102
 0.15
chr18_20920867_20921026 0.57 Rnf125
 ring finger protein 125
 23679
 0.17
chr17_30010480_30010631 0.56 Zfand3
 zinc finger, AN1-type domain 3
 2758
 0.19
chr6_57513458_57513615 0.55 Ppm1k
 protein phosphatase 1K (PP2C domain containing)
 2071
 0.25
chr2_164161443_164161616 0.54 n-R5s207
 nuclear encoded rRNA 5S 207
 4008
 0.11
chr10_121125476_121125627 0.54 Gm48410
 predicted gene, 48410
 10306
 0.16
chr6_17255791_17255960 0.54 Cav2
 caveolin 2
 25310
 0.17
chr7_35116533_35116684 0.53 Cebpa
 CCAAT/enhancer binding protein (C/EBP), alpha
 2685
 0.13
chr13_100532997_100533171 0.53 Ocln
 occludin
 19376
 0.11
chr1_58475799_58475950 0.52 Orc2
 origin recognition complex, subunit 2
 5575
 0.13
chr1_167320339_167320493 0.52 Tmco1
 transmembrane and coiled-coil domains 1
 6279
 0.12
chr10_116221046_116221335 0.50 Ptprr
 protein tyrosine phosphatase, receptor type, R
 24794
 0.18
chr15_55819504_55819678 0.49 Sntb1
 syntrophin, basic 1
 86719
 0.08
chr13_28654991_28655297 0.49 Mir6368
 microRNA 6368
 55729
 0.15
chr8_105746150_105746318 0.47 Gfod2
 glucose-fructose oxidoreductase domain containing 2
 12362
 0.09
chr8_70593155_70593355 0.47 Isyna1
 myo-inositol 1-phosphate synthase A1
 1118
 0.29
chr13_34301223_34301392 0.47 Gm47086
 predicted gene, 47086
 17501
 0.18
chr5_121838276_121838548 0.46 Sh2b3
 SH2B adaptor protein 3
 766
 0.47
chr19_29101814_29101986 0.45 Rcl1
 RNA terminal phosphate cyclase-like 1
 525
 0.69
chr6_128519043_128519655 0.45 Pzp
 PZP, alpha-2-macroglobulin like
 7354
 0.09
chr11_119834463_119834628 0.45 Rptoros
 regulatory associated protein of MTOR, complex 1, opposite strand
 180
 0.94
chr6_116747946_116748114 0.43 Gm22882
 predicted gene, 22882
 17622
 0.16
chr4_43181848_43182012 0.42 Unc13b
 unc-13 homolog B
 1362
 0.39
chr8_125337571_125337768 0.41 Gm16237
 predicted gene 16237
 110346
 0.06
chr14_8124267_8124431 0.41 Pxk
 PX domain containing serine/threonine kinase
 11005
 0.18
chr13_54101192_54101366 0.41 Sfxn1
 sideroflexin 1
 8568
 0.19
chr5_99362991_99363432 0.41 Gm35394
 predicted gene, 35394
 89116
 0.08
chr8_125381813_125381979 0.40 Sipa1l2
 signal-induced proliferation-associated 1 like 2
 110814
 0.06
chr15_11054061_11054248 0.40 Adamts12
 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12
 10636
 0.18
chr19_42581997_42582175 0.40 R3hcc1l
 R3H domain and coiled-coil containing 1 like
 925
 0.56
chr5_62858525_62858676 0.40 Dthd1
 death domain containing 1
 44777
 0.19
chr6_113991518_113991701 0.40 Gm15083
 predicted gene 15083
 13180
 0.17
chr1_184357776_184358209 0.39 Gm37223
 predicted gene, 37223
 337
 0.91
chr10_75742534_75742685 0.39 Cabin1
 calcineurin binding protein 1
 8838
 0.11
chr5_145994754_145994905 0.39 Cyp3a25
 cytochrome P450, family 3, subfamily a, polypeptide 25
 3186
 0.17
chr4_126113392_126113559 0.38 Stk40
 serine/threonine kinase 40
 4797
 0.12
chr15_93515418_93515569 0.38 Prickle1
 prickle planar cell polarity protein 1
 4030
 0.3
chr11_76849502_76849693 0.38 Cpd
 carboxypeptidase D
 2579
 0.29
chr3_102454630_102454805 0.38 Ngf
 nerve growth factor
 15202
 0.18
chr4_80931106_80931434 0.38 Lurap1l
 leucine rich adaptor protein 1-like
 20624
 0.22
chr16_22439730_22439912 0.37 Etv5
 ets variant 5
 102
 0.97
chr5_119576958_119577127 0.37 Tbx3os1
 T-box 3, opposite strand 1
 2096
 0.29
chr5_123201599_123201763 0.37 Gm43409
 predicted gene 43409
 10093
 0.1
chr12_8643417_8643595 0.37 Pum2
 pumilio RNA-binding family member 2
 30628
 0.17
chr10_37145852_37146014 0.37 5930403N24Rik
 RIKEN cDNA 5930403N24 gene
 4844
 0.21
chr3_142569357_142569508 0.37 Gbp3
 guanylate binding protein 3
 8198
 0.13
chr17_64643456_64643864 0.37 Man2a1
 mannosidase 2, alpha 1
 42924
 0.17
chr8_64790589_64790740 0.37 Klhl2
 kelch-like 2, Mayven
 9000
 0.16
chr13_29049878_29050059 0.36 A330102I10Rik
 RIKEN cDNA A330102I10 gene
 33260
 0.19
chr6_128523521_128524414 0.36 Pzp
 PZP, alpha-2-macroglobulin like
 2736
 0.13
chr7_49358786_49358938 0.36 Nav2
 neuron navigator 2
 5859
 0.24
chr14_57375309_57375470 0.36 Gm29717
 predicted gene, 29717
 9861
 0.14
chr13_95894500_95894710 0.36 Iqgap2
 IQ motif containing GTPase activating protein 2
 2122
 0.3
chr10_105311004_105311282 0.36 Gm48206
 predicted gene, 48206
 29106
 0.18
chr15_10183678_10183833 0.36 Prlr
 prolactin receptor
 5974
 0.31
chr4_132650270_132650435 0.35 Eya3
 EYA transcriptional coactivator and phosphatase 3
 6348
 0.17
chr14_27310963_27311149 0.35 Arhgef3
 Rho guanine nucleotide exchange factor (GEF) 3
 25010
 0.19
chr10_63226846_63227134 0.35 Herc4
 hect domain and RLD 4
 16820
 0.11
chr7_12929925_12930160 0.35 Gm26325
 predicted gene, 26325
 732
 0.4
chr6_71824307_71824486 0.35 Mrpl35
 mitochondrial ribosomal protein L35
 586
 0.6
chr17_86303142_86303298 0.35 2010106C02Rik
 RIKEN cDNA 2010106C02 gene
 16042
 0.26
chr16_22901028_22901197 0.35 Ahsg
 alpha-2-HS-glycoprotein
 6248
 0.12
chr5_63936466_63936784 0.34 Rell1
 RELT-like 1
 5711
 0.18
chr18_53745041_53745208 0.34 Cep120
 centrosomal protein 120
 516
 0.86
chr19_61029220_61029421 0.34 Gm22520
 predicted gene, 22520
 15775
 0.19
chr1_166032218_166032391 0.34 Gm7626
 predicted gene 7626
 11387
 0.15
chr15_82748520_82748679 0.34 Gm49433
 predicted gene, 49433
 6483
 0.1
chr1_105908668_105908838 0.34 Gm37779
 predicted gene, 37779
 17741
 0.16
chr18_41861273_41861424 0.34 Gm50410
 predicted gene, 50410
 13486
 0.22
chr4_95317985_95318146 0.34 Gm29064
 predicted gene 29064
 84725
 0.08
chr16_14155801_14155952 0.34 Marf1
 meiosis regulator and mRNA stability 1
 3391
 0.17
chr13_35023472_35023629 0.34 Eci2
 enoyl-Coenzyme A delta isomerase 2
 3544
 0.15
chr12_108264946_108265126 0.33 Ccdc85c
 coiled-coil domain containing 85C
 10097
 0.18
chr6_31317781_31317947 0.33 2210408F21Rik
 RIKEN cDNA 2210408F21 gene
 4107
 0.19
chr6_128481760_128482446 0.33 Pzp
 PZP, alpha-2-macroglobulin like
 5752
 0.09
chr3_142757820_142758243 0.33 Gtf2b
 general transcription factor IIB
 7014
 0.12
chr6_16701972_16702148 0.33 Gm36669
 predicted gene, 36669
 75464
 0.11
chr13_100849368_100849536 0.33 Gm29502
 predicted gene 29502
 2019
 0.24
chr5_122527903_122528070 0.33 Gm22965
 predicted gene, 22965
 21197
 0.09
chr13_91749969_91750270 0.33 Gm27656
 predicted gene, 27656
 1987
 0.26
chr10_61160789_61160964 0.33 Tbata
 thymus, brain and testes associated
 11078
 0.15
chr5_92773855_92774029 0.33 Mir1961
 microRNA 1961
 14620
 0.18
chr11_35970865_35971211 0.32 Wwc1
 WW, C2 and coiled-coil domain containing 1
 9489
 0.23
chr2_128172178_128172337 0.32 Gm14009
 predicted gene 14009
 17730
 0.2
chr1_174907689_174908002 0.32 Grem2
 gremlin 2, DAN family BMP antagonist
 13974
 0.29
chr5_90560915_90561091 0.32 Albfm1
 albumin superfamily member 1
 104
 0.94
chr10_94573136_94573386 0.32 Tmcc3
 transmembrane and coiled coil domains 3
 1996
 0.28
chrX_164035471_164035631 0.32 Car5b
 carbonic anhydrase 5b, mitochondrial
 7554
 0.2
chr5_145994529_145994680 0.32 Cyp3a25
 cytochrome P450, family 3, subfamily a, polypeptide 25
 2961
 0.18
chr1_9584205_9584668 0.32 Gm6161
 predicted gene 6161
 9888
 0.13
chr6_115730698_115730849 0.32 Tmem40
 transmembrane protein 40
 4178
 0.13
chr16_18430516_18430667 0.31 Txnrd2
 thioredoxin reductase 2
 1666
 0.22
chr17_84183727_84183878 0.31 Gm36279
 predicted gene, 36279
 1954
 0.27
chr3_108640526_108640690 0.31 Clcc1
 chloride channel CLIC-like 1
 13305
 0.11
chr17_29423486_29423671 0.31 Gm36199
 predicted gene, 36199
 9257
 0.12
chr6_28681979_28682177 0.31 Snd1
 staphylococcal nuclease and tudor domain containing 1
 22831
 0.21
chr3_142530130_142530290 0.31 Gbp7
 guanylate binding protein 7
 132
 0.95
chr10_82753022_82753185 0.31 Nfyb
 nuclear transcription factor-Y beta
 553
 0.67
chr3_29732792_29732959 0.31 Gm37557
 predicted gene, 37557
 38409
 0.19
chr11_80453320_80453471 0.30 Psmd11
 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11
 2973
 0.25
chr15_57979415_57979570 0.30 Fam83a
 family with sequence similarity 83, member A
 5927
 0.18
chr8_84765802_84765975 0.30 Nfix
 nuclear factor I/X
 7508
 0.11
chr10_94466409_94466580 0.30 Tmcc3
 transmembrane and coiled coil domains 3
 48363
 0.13
chr1_162247588_162247739 0.30 Mir214
 microRNA 214
 24295
 0.14
chr3_157723294_157723469 0.30 Gm33466
 predicted gene, 33466
 3027
 0.32
chr10_81172506_81172872 0.30 Eef2
 eukaryotic translation elongation factor 2
 3942
 0.08
chr12_85810078_85810229 0.30 Erg28
 ergosterol biosynthesis 28
 12097
 0.16
chr13_41250595_41250752 0.30 Smim13
 small integral membrane protein 13
 829
 0.5
chr11_49088297_49088883 0.30 Gm12188
 predicted gene 12188
 47
 0.79
chr10_17010158_17010311 0.30 Gm20125
 predicted gene, 20125
 13915
 0.28
chr17_70797462_70797613 0.30 Gm41609
 predicted gene, 41609
 8460
 0.13
chr16_26348570_26348826 0.30 Cldn1
 claudin 1
 12096
 0.29
chr5_124377210_124377362 0.29 Sbno1
 strawberry notch 1
 7523
 0.12
chr6_94549672_94549849 0.29 Slc25a26
 solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26
 15620
 0.2
chr1_103048975_103049149 0.29 Gm22034
 predicted gene, 22034
 95514
 0.09
chr2_62655069_62655412 0.29 Ifih1
 interferon induced with helicase C domain 1
 8985
 0.18
chr7_141184840_141184997 0.29 Gm22019
 predicted gene, 22019
 3607
 0.09
chr1_45922514_45922876 0.29 Slc40a1
 solute carrier family 40 (iron-regulated transporter), member 1
 614
 0.65
chr8_87121391_87121558 0.29 Gm27246
 predicted gene 27246
 6829
 0.19
chr13_17717656_17717837 0.29 Gm48621
 predicted gene, 48621
 7882
 0.12
chr3_98255193_98255424 0.29 Gm42821
 predicted gene 42821
 6709
 0.15
chr16_33892287_33892604 0.29 Itgb5
 integrin beta 5
 498
 0.81
chr6_126033747_126033913 0.28 Ntf3
 neurotrophin 3
 131130
 0.05
chr13_24958493_24958644 0.28 Gpld1
 glycosylphosphatidylinositol specific phospholipase D1
 2714
 0.2
chr13_4615952_4616121 0.28 Rpl29-ps2
 ribosomal protein L29, pseudogene 2
 1854
 0.3
chr7_132931708_132932726 0.28 1500002F19Rik
 RIKEN cDNA 1500002F19 gene
 1020
 0.34
chr7_141628129_141628296 0.28 Mir7063
 microRNA 7063
 7511
 0.13
chr16_22694632_22694783 0.28 Gm8118
 predicted gene 8118
 8513
 0.18
chr12_16870775_16871097 0.28 Gm36495
 predicted gene, 36495
 20055
 0.13
chr4_99028512_99028838 0.28 Angptl3
 angiopoietin-like 3
 2279
 0.28
chr14_49703822_49704015 0.28 Gm16082
 predicted gene 16082
 9704
 0.15
chr1_9787589_9787755 0.28 1700034P13Rik
 RIKEN cDNA 1700034P13 gene
 3894
 0.16
chr4_55408726_55408877 0.28 Gm12513
 predicted gene 12513
 506
 0.73
chr19_4051523_4051732 0.28 Gstp2
 glutathione S-transferase, pi 2
 5604
 0.07
chr9_61422608_61422759 0.28 Tle3
 transducin-like enhancer of split 3
 12746
 0.17
chr6_128482799_128482997 0.28 Pzp
 PZP, alpha-2-macroglobulin like
 4957
 0.1
chrX_93161079_93161239 0.28 Gm24123
 predicted gene, 24123
 3743
 0.22
chr3_145790883_145791049 0.28 Ddah1
 dimethylarginine dimethylaminohydrolase 1
 19513
 0.19
chr6_9077922_9078077 0.28 Gm35736
 predicted gene, 35736
 68767
 0.13
chr10_60349166_60349337 0.27 Vsir
 V-set immunoregulatory receptor
 72
 0.97
chr12_110871384_110871543 0.27 Cinp
 cyclin-dependent kinase 2 interacting protein
 5881
 0.1
chr18_23496939_23497187 0.27 Dtna
 dystrobrevin alpha
 228
 0.96
chr7_68696358_68696602 0.27 Gm44692
 predicted gene 44692
 29987
 0.18
chr17_56655322_56655554 0.27 Catsperd
 cation channel sperm associated auxiliary subunit delta
 3656
 0.13
chr11_94347313_94347820 0.27 Abcc3
 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
 3620
 0.18
chr5_102751686_102752074 0.27 Arhgap24
 Rho GTPase activating protein 24
 16891
 0.28
chr8_23284051_23284251 0.27 Gm24335
 predicted gene, 24335
 6013
 0.16
chr6_29833568_29833845 0.27 Ahcyl2
 S-adenosylhomocysteine hydrolase-like 2
 20054
 0.17
chr1_171786247_171786398 0.27 Slamf1
 signaling lymphocytic activation molecule family member 1
 19167
 0.11
chr7_135609772_135609956 0.27 Ptpre
 protein tyrosine phosphatase, receptor type, E
 4036
 0.22
chr7_35127993_35128152 0.27 Gm45091
 predicted gene 45091
 8467
 0.1
chr2_25156341_25156504 0.27 Gm13387
 predicted gene 13387
 11026
 0.07
chr19_53890337_53890577 0.27 Pdcd4
 programmed cell death 4
 1774
 0.29
chr6_86233931_86234108 0.27 Tgfa
 transforming growth factor alpha
 22425
 0.13
chr17_56170170_56170436 0.26 Gm44397
 predicted gene, 44397
 1822
 0.18
chr12_102711766_102711920 0.26 Itpk1
 inositol 1,3,4-triphosphate 5/6 kinase
 6913
 0.1
chr14_114062877_114063028 0.26 Gm18369
 predicted gene, 18369
 109491
 0.07
chr10_8092375_8092549 0.26 Gm48614
 predicted gene, 48614
 71170
 0.1
chr15_97590730_97591033 0.26 Gm49506
 predicted gene, 49506
 32591
 0.19
chr6_5517592_5517751 0.26 Pdk4
 pyruvate dehydrogenase kinase, isoenzyme 4
 21362
 0.26
chr1_63178308_63178488 0.26 Gm26457
 predicted gene, 26457
 279
 0.62
chr2_26314444_26314595 0.26 Gpsm1
 G-protein signalling modulator 1 (AGS3-like, C. elegans)
 996
 0.38
chr16_95842914_95843065 0.26 1600002D24Rik
 RIKEN cDNA 1600002D24 gene
 2781
 0.26
chr13_34239605_34239854 0.26 Slc22a23
 solute carrier family 22, member 23
 46198
 0.11
chr3_122247143_122247315 0.26 Gclm
 glutamate-cysteine ligase, modifier subunit
 1148
 0.3
chr17_29502998_29503149 0.26 Pim1
 proviral integration site 1
 9666
 0.1
chr2_166035845_166036012 0.26 Ncoa3
 nuclear receptor coactivator 3
 11990
 0.16
chr10_128271588_128271831 0.26 Stat2
 signal transducer and activator of transcription 2
 1133
 0.24
chr8_40659245_40659433 0.26 Adam24
 a disintegrin and metallopeptidase domain 24 (testase 1)
 15738
 0.13
chr18_44623567_44623739 0.26 A930012L18Rik
 RIKEN cDNA A930012L18 gene
 38012
 0.17
chr11_107121702_107121874 0.26 Bptf
 bromodomain PHD finger transcription factor
 10134
 0.16
chr2_155059266_155059435 0.26 a
 nonagouti
 11735
 0.13
chr7_87235141_87235326 0.26 Gm6230
 predicted gene 6230
 7652
 0.23
chr5_135118666_135118877 0.26 Gm43500
 predicted gene 43500
 4522
 0.11
chr11_78418219_78418374 0.25 Slc13a2
 solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2
 3921
 0.12
chr16_91466662_91466825 0.25 Gm49626
 predicted gene, 49626
 1618
 0.17
chr9_118928821_118928982 0.25 Ctdspl
 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
 966
 0.46
chr13_91759904_91760091 0.25 Gm27656
 predicted gene, 27656
 7891
 0.15
chr12_18606247_18606408 0.25 Gm48398
 predicted gene, 48398
 4057
 0.19
chr15_58747025_58747176 0.25 Gm20712
 predicted gene 20712
 34851
 0.15
chr4_54905681_54905846 0.25 Zfp462
 zinc finger protein 462
 39285
 0.17
chr1_36075710_36075890 0.25 Hs6st1
 heparan sulfate 6-O-sulfotransferase 1
 7400
 0.15
chr2_170175810_170175971 0.25 Zfp217
 zinc finger protein 217
 27787
 0.23
chr15_6709205_6709602 0.25 Rictor
 RPTOR independent companion of MTOR, complex 2
 1020
 0.58
chr12_86476167_86476343 0.25 Esrrb
 estrogen related receptor, beta
 6138
 0.27
chr15_31062621_31062832 0.25 4930430F21Rik
 RIKEN cDNA 4930430F21 gene
 23598
 0.19
chr1_37491813_37491971 0.25 Gm43213
 predicted gene 43213
 2910
 0.19
chr6_120580202_120580372 0.24 Gm44124
 predicted gene, 44124
 111
 0.95
chr18_39430680_39430864 0.24 Gm15337
 predicted gene 15337
 41347
 0.15
chr13_35616741_35616920 0.24 Gm48707
 predicted gene, 48707
 43
 0.98
chr8_88983561_88983712 0.24 Mir8110
 microRNA 8110
 41099
 0.17

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1 0.6 GO:0006048 UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1 0.2 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1 0.4 GO:0098728 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1 0.1 GO:0071288 cellular response to mercury ion(GO:0071288)
0.1 0.2 GO:0034395 regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.1 0.3 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1 0.3 GO:2000562 negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.1 0.2 GO:0038161 prolactin signaling pathway(GO:0038161)
0.1 0.2 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.1 0.3 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.1 0.2 GO:0071816 protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1 0.2 GO:1900740 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1 0.2 GO:0061092 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1 0.2 GO:2000302 positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.1 0.2 GO:0051684 maintenance of Golgi location(GO:0051684)
0.1 0.2 GO:0030242 pexophagy(GO:0030242)
0.0 0.1 GO:0035771 interleukin-4-mediated signaling pathway(GO:0035771)
0.0 0.2 GO:0061428 negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0 0.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.0 0.1 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.2 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.1 GO:0060300 regulation of cytokine activity(GO:0060300)
0.0 0.1 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578)
0.0 0.1 GO:0015817 histidine transport(GO:0015817)
0.0 0.1 GO:0021564 vagus nerve development(GO:0021564)
0.0 0.1 GO:0070669 response to interleukin-2(GO:0070669)
0.0 0.1 GO:0051572 negative regulation of histone H3-K4 methylation(GO:0051572)
0.0 0.2 GO:0052805 histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0 0.1 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0 0.1 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
0.0 0.5 GO:0044406 adhesion of symbiont to host(GO:0044406)
0.0 0.1 GO:0019065 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0 0.2 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.0 0.1 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.1 GO:0030423 targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0 0.1 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.0 0.1 GO:0034499 late endosome to Golgi transport(GO:0034499)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.2 GO:0060613 fat pad development(GO:0060613)
0.0 0.1 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0 0.1 GO:2000504 positive regulation of blood vessel remodeling(GO:2000504)
0.0 0.2 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0 0.1 GO:1904192 cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.0 0.1 GO:0052203 modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0 0.1 GO:0015770 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0 0.1 GO:0051890 regulation of cardioblast differentiation(GO:0051890)
0.0 0.2 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.0 0.1 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0 0.1 GO:1903334 positive regulation of protein folding(GO:1903334)
0.0 0.1 GO:2001016 positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0 0.1 GO:1990168 protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0 0.0 GO:0010911 regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0 0.3 GO:0045821 positive regulation of glycolytic process(GO:0045821)
0.0 0.1 GO:0000055 ribosomal large subunit export from nucleus(GO:0000055)
0.0 0.0 GO:0007354 zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0 0.2 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0 0.2 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.0 0.2 GO:0007288 sperm axoneme assembly(GO:0007288)
0.0 0.0 GO:0035905 ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0 0.1 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.0 0.0 GO:1901844 regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0 0.2 GO:0046598 positive regulation of viral entry into host cell(GO:0046598)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.0 GO:0098902 regulation of membrane depolarization during action potential(GO:0098902)
0.0 0.1 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.1 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.0 0.1 GO:0070358 actin polymerization-dependent cell motility(GO:0070358)
0.0 0.2 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0 0.1 GO:0021886 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) facioacoustic ganglion development(GO:1903375)
0.0 0.1 GO:0044004 killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0 0.0 GO:0090310 negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0 0.0 GO:0000189 MAPK import into nucleus(GO:0000189)
0.0 0.0 GO:0070782 phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0 0.2 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.0 0.1 GO:0006659 phosphatidylserine biosynthetic process(GO:0006659)
0.0 0.1 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.0 GO:0002905 mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0 0.1 GO:0042851 L-alanine metabolic process(GO:0042851)
0.0 0.1 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.0 0.1 GO:0021780 oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0 0.1 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.0 0.1 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)
0.0 0.0 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0 0.1 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.0 0.1 GO:0006216 cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.1 GO:0002314 germinal center B cell differentiation(GO:0002314)
0.0 0.1 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0 0.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.0 GO:0014834 skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0 0.1 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.0 0.1 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0 0.0 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0061101 neuroendocrine cell differentiation(GO:0061101)
0.0 0.0 GO:2000173 negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0 0.0 GO:0071877 regulation of adrenergic receptor signaling pathway(GO:0071877)
0.0 0.0 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.1 GO:0090232 positive regulation of spindle checkpoint(GO:0090232)
0.0 0.1 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:0034627 'de novo' NAD biosynthetic process(GO:0034627)
0.0 0.0 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.1 GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0 0.1 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0 0.0 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.0 0.0 GO:0090170 regulation of Golgi inheritance(GO:0090170)
0.0 0.1 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0033278 cell proliferation in midbrain(GO:0033278)
0.0 0.0 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.1 GO:0006572 tyrosine catabolic process(GO:0006572)
0.0 0.0 GO:0072034 renal vesicle induction(GO:0072034)
0.0 0.0 GO:0070947 neutrophil mediated killing of fungus(GO:0070947)
0.0 0.0 GO:0045914 negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0 0.1 GO:0006566 threonine metabolic process(GO:0006566)
0.0 0.1 GO:0046110 xanthine catabolic process(GO:0009115) xanthine metabolic process(GO:0046110)
0.0 0.0 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0 0.0 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.0 0.1 GO:0006527 arginine catabolic process(GO:0006527)
0.0 0.0 GO:0021586 pons maturation(GO:0021586)
0.0 0.1 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0 0.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0006020 inositol metabolic process(GO:0006020)
0.0 0.0 GO:0090210 regulation of establishment of blood-brain barrier(GO:0090210)
0.0 0.1 GO:0015879 carnitine transport(GO:0015879)
0.0 0.1 GO:0006930 substrate-dependent cell migration, cell extension(GO:0006930)
0.0 0.1 GO:0030836 positive regulation of actin filament depolymerization(GO:0030836)
0.0 0.1 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 0.0 GO:0045196 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.0 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.0 GO:2000110 negative regulation of macrophage apoptotic process(GO:2000110)
0.0 0.0 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.0 0.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.0 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.0 GO:0060112 generation of ovulation cycle rhythm(GO:0060112)
0.0 0.0 GO:0010482 epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0 0.0 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.0 GO:0003100 regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0 0.1 GO:0035106 operant conditioning(GO:0035106)
0.0 0.1 GO:0070493 thrombin receptor signaling pathway(GO:0070493)
0.0 0.0 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.2 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
0.0 0.0 GO:2000705 regulation of dense core granule biogenesis(GO:2000705)
0.0 0.0 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.1 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.0 0.0 GO:1901740 negative regulation of myoblast fusion(GO:1901740)
0.0 0.1 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.0 GO:1905065 positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0 0.0 GO:0010025 wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0 0.0 GO:0032497 detection of lipopolysaccharide(GO:0032497)
0.0 0.0 GO:0071332 cellular response to fructose stimulus(GO:0071332)
0.0 0.0 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.2 GO:0035278 miRNA mediated inhibition of translation(GO:0035278)
0.0 0.0 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0 0.0 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.0 0.1 GO:0051764 actin crosslink formation(GO:0051764)
0.0 0.0 GO:0001834 trophectodermal cell proliferation(GO:0001834)
0.0 0.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.1 GO:0071318 cellular response to ATP(GO:0071318)
0.0 0.0 GO:1903392 negative regulation of adherens junction organization(GO:1903392)
0.0 0.0 GO:0046499 S-adenosylmethioninamine metabolic process(GO:0046499)
0.0 0.1 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0 0.0 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.0 GO:0035590 purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0 0.1 GO:0072015 glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0 0.0 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0 0.0 GO:0001844 protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:0001844)
0.0 0.0 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0 0.0 GO:1990036 calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.0 0.0 GO:0043622 cortical microtubule organization(GO:0043622)
0.0 0.0 GO:0006222 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0 0.1 GO:0006824 cobalt ion transport(GO:0006824)
0.0 0.1 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.0 0.1 GO:0033762 response to glucagon(GO:0033762)
0.0 0.0 GO:0009448 gamma-aminobutyric acid metabolic process(GO:0009448)
0.0 0.0 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0 0.0 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.0 GO:0006481 C-terminal protein methylation(GO:0006481)
0.0 0.1 GO:2000821 regulation of grooming behavior(GO:2000821)
0.0 0.1 GO:1905097 regulation of guanyl-nucleotide exchange factor activity(GO:1905097)
0.0 0.0 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.0 GO:0071922 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0 0.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0 0.0 GO:0030091 protein repair(GO:0030091)
0.0 0.0 GO:2000195 negative regulation of female gonad development(GO:2000195)
0.0 0.0 GO:0007412 axon target recognition(GO:0007412)
0.0 0.0 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0 0.0 GO:0071394 cellular response to testosterone stimulus(GO:0071394)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
0.1 0.2 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0 0.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.2 GO:0009279 cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0 0.1 GO:0097443 sorting endosome(GO:0097443)
0.0 0.4 GO:0031932 TORC2 complex(GO:0031932)
0.0 0.2 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.1 GO:0036488 CHOP-C/EBP complex(GO:0036488)
0.0 0.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 0.2 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0031931 TORC1 complex(GO:0031931)
0.0 0.1 GO:0070531 BRCA1-A complex(GO:0070531)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0 0.1 GO:0042585 germinal vesicle(GO:0042585)
0.0 0.1 GO:0030289 protein phosphatase 4 complex(GO:0030289)
0.0 0.1 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.0 0.1 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.1 GO:0020016 ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0 0.1 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.1 GO:0097513 myosin II filament(GO:0097513)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.0 0.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.0 GO:0097427 microtubule bundle(GO:0097427)
0.0 0.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0 0.1 GO:0016589 NURF complex(GO:0016589)
0.0 0.2 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 0.0 GO:0032010 phagolysosome(GO:0032010)
0.0 0.1 GO:0030008 TRAPP complex(GO:0030008)
0.0 0.1 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 0.1 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.0 0.0 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.2 GO:0043218 compact myelin(GO:0043218)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.1 GO:0070578 RISC-loading complex(GO:0070578)
0.0 0.1 GO:0044326 dendritic spine neck(GO:0044326)
0.0 0.0 GO:0097057 TRAF2-GSTP1 complex(GO:0097057)
0.0 0.0 GO:0017133 mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.3 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 0.1 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.0 GO:1990357 terminal web(GO:1990357)
0.0 0.0 GO:0032299 ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0043338 CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.1 0.2 GO:0045134 uridine-diphosphatase activity(GO:0045134)
0.1 0.2 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.2 GO:0008390 testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.0 0.3 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 0.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
0.0 0.2 GO:0048403 brain-derived neurotrophic factor binding(GO:0048403)
0.0 0.1 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.0 0.1 GO:0045340 mercury ion binding(GO:0045340)
0.0 0.1 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290)
0.0 0.0 GO:0015137 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0 0.1 GO:0046573 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.2 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.0 0.2 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0 0.1 GO:0015157 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0 0.1 GO:0042015 interleukin-20 binding(GO:0042015)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0 0.1 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.1 GO:0047105 aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0 0.3 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.0 0.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.0 0.1 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.1 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0050693 LBD domain binding(GO:0050693)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.1 GO:0015093 ferrous iron transmembrane transporter activity(GO:0015093)
0.0 0.1 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.1 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0 0.1 GO:0071209 U7 snRNA binding(GO:0071209)
0.0 0.1 GO:0032767 copper-dependent protein binding(GO:0032767)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.0 GO:0016015 morphogen activity(GO:0016015)
0.0 0.1 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0001849 complement component C1q binding(GO:0001849)
0.0 0.1 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.1 GO:0015199 amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0 0.1 GO:0036137 kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0 0.1 GO:0036122 BMP binding(GO:0036122)
0.0 0.1 GO:0004430 1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0 0.0 GO:0031750 D3 dopamine receptor binding(GO:0031750)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.0 GO:0051718 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 0.0 GO:0019002 GMP binding(GO:0019002)
0.0 0.2 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.1 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.0 GO:0004739 pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0 0.1 GO:0005131 growth hormone receptor binding(GO:0005131)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.0 GO:0004779 sulfate adenylyltransferase activity(GO:0004779)
0.0 0.0 GO:0043546 molybdopterin cofactor binding(GO:0043546)
0.0 0.1 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0 0.0 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.0 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.0 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.1 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.1 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.0 0.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.1 GO:0070883 pre-miRNA binding(GO:0070883)
0.0 0.0 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.1 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.0 0.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.0 GO:0017153 sodium:dicarboxylate symporter activity(GO:0017153)
0.0 0.0 GO:0019961 interferon binding(GO:0019961)
0.0 0.1 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.0 0.1 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.0 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.0 GO:0004165 dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0 0.1 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0 0.0 GO:0035939 microsatellite binding(GO:0035939)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.0 GO:0015181 arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.0 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.0 GO:0003986 acetyl-CoA hydrolase activity(GO:0003986)
0.0 0.0 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.0 0.1 GO:0004769 steroid delta-isomerase activity(GO:0004769)
0.0 0.2 GO:0016780 phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0 0.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.0 GO:0004854 xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.0 0.0 GO:0033142 progesterone receptor binding(GO:0033142)
0.0 0.1 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.0 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 0.0 GO:0034889 alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0 0.0 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.0 0.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 0.0 PID ALK2 PATHWAY ALK2 signaling events
0.0 0.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.0 0.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 0.1 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.0 0.1 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.0 0.1 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 0.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.5 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 0.1 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.0 0.2 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.0 0.1 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.0 0.2 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.2 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 0.1 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0 0.2 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.0 0.2 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.0 0.2 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.0 0.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.0 0.4 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.0 0.1 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.2 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0 0.1 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0 0.2 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.0 0.1 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.0 0.1 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.1 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0 0.1 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks