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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Foxo3

Z-value: 1.23

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Transcription factors associated with Foxo3

Gene Symbol	Gene ID	Gene Info
Foxo3 Ensembl NCBI MGI UniProt	ENSMUSG00000048756.5	Foxo3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Foxo3	chr10_42271116_42271452	5412	0.273623	-0.95	3.1e-03	Click!
Foxo3	chr10_42226224_42226388	32060	0.203915	0.95	4.0e-03	Click!
Foxo3	chr10_42251679_42251844	6605	0.273648	-0.94	6.1e-03	Click!
Foxo3	chr10_42211682_42211846	46602	0.162786	-0.93	6.5e-03	Click!
Foxo3	chr10_42233360_42233752	24810	0.224152	-0.93	7.4e-03	Click!

Activity of the Foxo3 motif across conditions

Conditions sorted by the z-value of the Foxo3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_25648898_25649067	1.00	Gm22645	predicted gene, 22645	45238	0.05
chr5_27411249_27411405	0.84	Speer4b	spermatogenesis associated glutamate (E)-rich protein 4B	90035	0.09
chr1_184330776_184331172	0.78	Gm37223	predicted gene, 37223	27355	0.2
chr13_37468607_37468985	0.76	Gm47731	predicted gene, 47731	3242	0.13
chr3_69778568_69778734	0.71	Nmd3	NMD3 ribosome export adaptor	32219	0.16
chr2_158153808_158154000	0.70	Tgm2	transglutaminase 2, C polypeptide	7468	0.16
chr12_71430131_71430651	0.66	1700083H02Rik	RIKEN cDNA 1700083H02 gene	46183	0.12
chr19_6041292_6041476	0.64	Gm8034	predicted gene 8034	3438	0.07
chr2_25363590_25363748	0.62	Uap1l1	UDP-N-acteylglucosamine pyrophosphorylase 1-like 1	29	0.93
chr5_8962552_8962757	0.60	Abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	4102	0.15
chr18_20920867_20921026	0.57	Rnf125	ring finger protein 125	23679	0.17
chr17_30010480_30010631	0.56	Zfand3	zinc finger, AN1-type domain 3	2758	0.19
chr6_57513458_57513615	0.55	Ppm1k	protein phosphatase 1K (PP2C domain containing)	2071	0.25
chr2_164161443_164161616	0.54	n-R5s207	nuclear encoded rRNA 5S 207	4008	0.11
chr10_121125476_121125627	0.54	Gm48410	predicted gene, 48410	10306	0.16
chr6_17255791_17255960	0.54	Cav2	caveolin 2	25310	0.17
chr7_35116533_35116684	0.53	Cebpa	CCAAT/enhancer binding protein (C/EBP), alpha	2685	0.13
chr13_100532997_100533171	0.53	Ocln	occludin	19376	0.11
chr1_58475799_58475950	0.52	Orc2	origin recognition complex, subunit 2	5575	0.13
chr1_167320339_167320493	0.52	Tmco1	transmembrane and coiled-coil domains 1	6279	0.12
chr10_116221046_116221335	0.50	Ptprr	protein tyrosine phosphatase, receptor type, R	24794	0.18
chr15_55819504_55819678	0.49	Sntb1	syntrophin, basic 1	86719	0.08
chr13_28654991_28655297	0.49	Mir6368	microRNA 6368	55729	0.15
chr8_105746150_105746318	0.47	Gfod2	glucose-fructose oxidoreductase domain containing 2	12362	0.09
chr8_70593155_70593355	0.47	Isyna1	myo-inositol 1-phosphate synthase A1	1118	0.29
chr13_34301223_34301392	0.47	Gm47086	predicted gene, 47086	17501	0.18
chr5_121838276_121838548	0.46	Sh2b3	SH2B adaptor protein 3	766	0.47
chr19_29101814_29101986	0.45	Rcl1	RNA terminal phosphate cyclase-like 1	525	0.69
chr6_128519043_128519655	0.45	Pzp	PZP, alpha-2-macroglobulin like	7354	0.09
chr11_119834463_119834628	0.45	Rptoros	regulatory associated protein of MTOR, complex 1, opposite strand	180	0.94
chr6_116747946_116748114	0.43	Gm22882	predicted gene, 22882	17622	0.16
chr4_43181848_43182012	0.42	Unc13b	unc-13 homolog B	1362	0.39
chr8_125337571_125337768	0.41	Gm16237	predicted gene 16237	110346	0.06
chr14_8124267_8124431	0.41	Pxk	PX domain containing serine/threonine kinase	11005	0.18
chr13_54101192_54101366	0.41	Sfxn1	sideroflexin 1	8568	0.19
chr5_99362991_99363432	0.41	Gm35394	predicted gene, 35394	89116	0.08
chr8_125381813_125381979	0.40	Sipa1l2	signal-induced proliferation-associated 1 like 2	110814	0.06
chr15_11054061_11054248	0.40	Adamts12	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12	10636	0.18
chr19_42581997_42582175	0.40	R3hcc1l	R3H domain and coiled-coil containing 1 like	925	0.56
chr5_62858525_62858676	0.40	Dthd1	death domain containing 1	44777	0.19
chr6_113991518_113991701	0.40	Gm15083	predicted gene 15083	13180	0.17
chr1_184357776_184358209	0.39	Gm37223	predicted gene, 37223	337	0.91
chr10_75742534_75742685	0.39	Cabin1	calcineurin binding protein 1	8838	0.11
chr5_145994754_145994905	0.39	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	3186	0.17
chr4_126113392_126113559	0.38	Stk40	serine/threonine kinase 40	4797	0.12
chr15_93515418_93515569	0.38	Prickle1	prickle planar cell polarity protein 1	4030	0.3
chr11_76849502_76849693	0.38	Cpd	carboxypeptidase D	2579	0.29
chr3_102454630_102454805	0.38	Ngf	nerve growth factor	15202	0.18
chr4_80931106_80931434	0.38	Lurap1l	leucine rich adaptor protein 1-like	20624	0.22
chr16_22439730_22439912	0.37	Etv5	ets variant 5	102	0.97
chr5_119576958_119577127	0.37	Tbx3os1	T-box 3, opposite strand 1	2096	0.29
chr5_123201599_123201763	0.37	Gm43409	predicted gene 43409	10093	0.1
chr12_8643417_8643595	0.37	Pum2	pumilio RNA-binding family member 2	30628	0.17
chr10_37145852_37146014	0.37	5930403N24Rik	RIKEN cDNA 5930403N24 gene	4844	0.21
chr3_142569357_142569508	0.37	Gbp3	guanylate binding protein 3	8198	0.13
chr17_64643456_64643864	0.37	Man2a1	mannosidase 2, alpha 1	42924	0.17
chr8_64790589_64790740	0.37	Klhl2	kelch-like 2, Mayven	9000	0.16
chr13_29049878_29050059	0.36	A330102I10Rik	RIKEN cDNA A330102I10 gene	33260	0.19
chr6_128523521_128524414	0.36	Pzp	PZP, alpha-2-macroglobulin like	2736	0.13
chr7_49358786_49358938	0.36	Nav2	neuron navigator 2	5859	0.24
chr14_57375309_57375470	0.36	Gm29717	predicted gene, 29717	9861	0.14
chr13_95894500_95894710	0.36	Iqgap2	IQ motif containing GTPase activating protein 2	2122	0.3
chr10_105311004_105311282	0.36	Gm48206	predicted gene, 48206	29106	0.18
chr15_10183678_10183833	0.36	Prlr	prolactin receptor	5974	0.31
chr4_132650270_132650435	0.35	Eya3	EYA transcriptional coactivator and phosphatase 3	6348	0.17
chr14_27310963_27311149	0.35	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	25010	0.19
chr10_63226846_63227134	0.35	Herc4	hect domain and RLD 4	16820	0.11
chr7_12929925_12930160	0.35	Gm26325	predicted gene, 26325	732	0.4
chr6_71824307_71824486	0.35	Mrpl35	mitochondrial ribosomal protein L35	586	0.6
chr17_86303142_86303298	0.35	2010106C02Rik	RIKEN cDNA 2010106C02 gene	16042	0.26
chr16_22901028_22901197	0.35	Ahsg	alpha-2-HS-glycoprotein	6248	0.12
chr5_63936466_63936784	0.34	Rell1	RELT-like 1	5711	0.18
chr18_53745041_53745208	0.34	Cep120	centrosomal protein 120	516	0.86
chr19_61029220_61029421	0.34	Gm22520	predicted gene, 22520	15775	0.19
chr1_166032218_166032391	0.34	Gm7626	predicted gene 7626	11387	0.15
chr15_82748520_82748679	0.34	Gm49433	predicted gene, 49433	6483	0.1
chr1_105908668_105908838	0.34	Gm37779	predicted gene, 37779	17741	0.16
chr18_41861273_41861424	0.34	Gm50410	predicted gene, 50410	13486	0.22
chr4_95317985_95318146	0.34	Gm29064	predicted gene 29064	84725	0.08
chr16_14155801_14155952	0.34	Marf1	meiosis regulator and mRNA stability 1	3391	0.17
chr13_35023472_35023629	0.34	Eci2	enoyl-Coenzyme A delta isomerase 2	3544	0.15
chr12_108264946_108265126	0.33	Ccdc85c	coiled-coil domain containing 85C	10097	0.18
chr6_31317781_31317947	0.33	2210408F21Rik	RIKEN cDNA 2210408F21 gene	4107	0.19
chr6_128481760_128482446	0.33	Pzp	PZP, alpha-2-macroglobulin like	5752	0.09
chr3_142757820_142758243	0.33	Gtf2b	general transcription factor IIB	7014	0.12
chr6_16701972_16702148	0.33	Gm36669	predicted gene, 36669	75464	0.11
chr13_100849368_100849536	0.33	Gm29502	predicted gene 29502	2019	0.24
chr5_122527903_122528070	0.33	Gm22965	predicted gene, 22965	21197	0.09
chr13_91749969_91750270	0.33	Gm27656	predicted gene, 27656	1987	0.26
chr10_61160789_61160964	0.33	Tbata	thymus, brain and testes associated	11078	0.15
chr5_92773855_92774029	0.33	Mir1961	microRNA 1961	14620	0.18
chr11_35970865_35971211	0.32	Wwc1	WW, C2 and coiled-coil domain containing 1	9489	0.23
chr2_128172178_128172337	0.32	Gm14009	predicted gene 14009	17730	0.2
chr1_174907689_174908002	0.32	Grem2	gremlin 2, DAN family BMP antagonist	13974	0.29
chr5_90560915_90561091	0.32	Albfm1	albumin superfamily member 1	104	0.94
chr10_94573136_94573386	0.32	Tmcc3	transmembrane and coiled coil domains 3	1996	0.28
chrX_164035471_164035631	0.32	Car5b	carbonic anhydrase 5b, mitochondrial	7554	0.2
chr5_145994529_145994680	0.32	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	2961	0.18
chr1_9584205_9584668	0.32	Gm6161	predicted gene 6161	9888	0.13
chr6_115730698_115730849	0.32	Tmem40	transmembrane protein 40	4178	0.13
chr16_18430516_18430667	0.31	Txnrd2	thioredoxin reductase 2	1666	0.22
chr17_84183727_84183878	0.31	Gm36279	predicted gene, 36279	1954	0.27
chr3_108640526_108640690	0.31	Clcc1	chloride channel CLIC-like 1	13305	0.11
chr17_29423486_29423671	0.31	Gm36199	predicted gene, 36199	9257	0.12
chr6_28681979_28682177	0.31	Snd1	staphylococcal nuclease and tudor domain containing 1	22831	0.21
chr3_142530130_142530290	0.31	Gbp7	guanylate binding protein 7	132	0.95
chr10_82753022_82753185	0.31	Nfyb	nuclear transcription factor-Y beta	553	0.67
chr3_29732792_29732959	0.31	Gm37557	predicted gene, 37557	38409	0.19
chr11_80453320_80453471	0.30	Psmd11	proteasome (prosome, macropain) 26S subunit, non-ATPase, 11	2973	0.25
chr15_57979415_57979570	0.30	Fam83a	family with sequence similarity 83, member A	5927	0.18
chr8_84765802_84765975	0.30	Nfix	nuclear factor I/X	7508	0.11
chr10_94466409_94466580	0.30	Tmcc3	transmembrane and coiled coil domains 3	48363	0.13
chr1_162247588_162247739	0.30	Mir214	microRNA 214	24295	0.14
chr3_157723294_157723469	0.30	Gm33466	predicted gene, 33466	3027	0.32
chr10_81172506_81172872	0.30	Eef2	eukaryotic translation elongation factor 2	3942	0.08
chr12_85810078_85810229	0.30	Erg28	ergosterol biosynthesis 28	12097	0.16
chr13_41250595_41250752	0.30	Smim13	small integral membrane protein 13	829	0.5
chr11_49088297_49088883	0.30	Gm12188	predicted gene 12188	47	0.79
chr10_17010158_17010311	0.30	Gm20125	predicted gene, 20125	13915	0.28
chr17_70797462_70797613	0.30	Gm41609	predicted gene, 41609	8460	0.13
chr16_26348570_26348826	0.30	Cldn1	claudin 1	12096	0.29
chr5_124377210_124377362	0.29	Sbno1	strawberry notch 1	7523	0.12
chr6_94549672_94549849	0.29	Slc25a26	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26	15620	0.2
chr1_103048975_103049149	0.29	Gm22034	predicted gene, 22034	95514	0.09
chr2_62655069_62655412	0.29	Ifih1	interferon induced with helicase C domain 1	8985	0.18
chr7_141184840_141184997	0.29	Gm22019	predicted gene, 22019	3607	0.09
chr1_45922514_45922876	0.29	Slc40a1	solute carrier family 40 (iron-regulated transporter), member 1	614	0.65
chr8_87121391_87121558	0.29	Gm27246	predicted gene 27246	6829	0.19
chr13_17717656_17717837	0.29	Gm48621	predicted gene, 48621	7882	0.12
chr3_98255193_98255424	0.29	Gm42821	predicted gene 42821	6709	0.15
chr16_33892287_33892604	0.29	Itgb5	integrin beta 5	498	0.81
chr6_126033747_126033913	0.28	Ntf3	neurotrophin 3	131130	0.05
chr13_24958493_24958644	0.28	Gpld1	glycosylphosphatidylinositol specific phospholipase D1	2714	0.2
chr13_4615952_4616121	0.28	Rpl29-ps2	ribosomal protein L29, pseudogene 2	1854	0.3
chr7_132931708_132932726	0.28	1500002F19Rik	RIKEN cDNA 1500002F19 gene	1020	0.34
chr7_141628129_141628296	0.28	Mir7063	microRNA 7063	7511	0.13
chr16_22694632_22694783	0.28	Gm8118	predicted gene 8118	8513	0.18
chr12_16870775_16871097	0.28	Gm36495	predicted gene, 36495	20055	0.13
chr4_99028512_99028838	0.28	Angptl3	angiopoietin-like 3	2279	0.28
chr14_49703822_49704015	0.28	Gm16082	predicted gene 16082	9704	0.15
chr1_9787589_9787755	0.28	1700034P13Rik	RIKEN cDNA 1700034P13 gene	3894	0.16
chr4_55408726_55408877	0.28	Gm12513	predicted gene 12513	506	0.73
chr19_4051523_4051732	0.28	Gstp2	glutathione S-transferase, pi 2	5604	0.07
chr9_61422608_61422759	0.28	Tle3	transducin-like enhancer of split 3	12746	0.17
chr6_128482799_128482997	0.28	Pzp	PZP, alpha-2-macroglobulin like	4957	0.1
chrX_93161079_93161239	0.28	Gm24123	predicted gene, 24123	3743	0.22
chr3_145790883_145791049	0.28	Ddah1	dimethylarginine dimethylaminohydrolase 1	19513	0.19
chr6_9077922_9078077	0.28	Gm35736	predicted gene, 35736	68767	0.13
chr10_60349166_60349337	0.27	Vsir	V-set immunoregulatory receptor	72	0.97
chr12_110871384_110871543	0.27	Cinp	cyclin-dependent kinase 2 interacting protein	5881	0.1
chr18_23496939_23497187	0.27	Dtna	dystrobrevin alpha	228	0.96
chr7_68696358_68696602	0.27	Gm44692	predicted gene 44692	29987	0.18
chr17_56655322_56655554	0.27	Catsperd	cation channel sperm associated auxiliary subunit delta	3656	0.13
chr11_94347313_94347820	0.27	Abcc3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	3620	0.18
chr5_102751686_102752074	0.27	Arhgap24	Rho GTPase activating protein 24	16891	0.28
chr8_23284051_23284251	0.27	Gm24335	predicted gene, 24335	6013	0.16
chr6_29833568_29833845	0.27	Ahcyl2	S-adenosylhomocysteine hydrolase-like 2	20054	0.17
chr1_171786247_171786398	0.27	Slamf1	signaling lymphocytic activation molecule family member 1	19167	0.11
chr7_135609772_135609956	0.27	Ptpre	protein tyrosine phosphatase, receptor type, E	4036	0.22
chr7_35127993_35128152	0.27	Gm45091	predicted gene 45091	8467	0.1
chr2_25156341_25156504	0.27	Gm13387	predicted gene 13387	11026	0.07
chr19_53890337_53890577	0.27	Pdcd4	programmed cell death 4	1774	0.29
chr6_86233931_86234108	0.27	Tgfa	transforming growth factor alpha	22425	0.13
chr17_56170170_56170436	0.26	Gm44397	predicted gene, 44397	1822	0.18
chr12_102711766_102711920	0.26	Itpk1	inositol 1,3,4-triphosphate 5/6 kinase	6913	0.1
chr14_114062877_114063028	0.26	Gm18369	predicted gene, 18369	109491	0.07
chr10_8092375_8092549	0.26	Gm48614	predicted gene, 48614	71170	0.1
chr15_97590730_97591033	0.26	Gm49506	predicted gene, 49506	32591	0.19
chr6_5517592_5517751	0.26	Pdk4	pyruvate dehydrogenase kinase, isoenzyme 4	21362	0.26
chr1_63178308_63178488	0.26	Gm26457	predicted gene, 26457	279	0.62
chr2_26314444_26314595	0.26	Gpsm1	G-protein signalling modulator 1 (AGS3-like, C. elegans)	996	0.38
chr16_95842914_95843065	0.26	1600002D24Rik	RIKEN cDNA 1600002D24 gene	2781	0.26
chr13_34239605_34239854	0.26	Slc22a23	solute carrier family 22, member 23	46198	0.11
chr3_122247143_122247315	0.26	Gclm	glutamate-cysteine ligase, modifier subunit	1148	0.3
chr17_29502998_29503149	0.26	Pim1	proviral integration site 1	9666	0.1
chr2_166035845_166036012	0.26	Ncoa3	nuclear receptor coactivator 3	11990	0.16
chr10_128271588_128271831	0.26	Stat2	signal transducer and activator of transcription 2	1133	0.24
chr8_40659245_40659433	0.26	Adam24	a disintegrin and metallopeptidase domain 24 (testase 1)	15738	0.13
chr18_44623567_44623739	0.26	A930012L18Rik	RIKEN cDNA A930012L18 gene	38012	0.17
chr11_107121702_107121874	0.26	Bptf	bromodomain PHD finger transcription factor	10134	0.16
chr2_155059266_155059435	0.26	a	nonagouti	11735	0.13
chr7_87235141_87235326	0.26	Gm6230	predicted gene 6230	7652	0.23
chr5_135118666_135118877	0.26	Gm43500	predicted gene 43500	4522	0.11
chr11_78418219_78418374	0.25	Slc13a2	solute carrier family 13 (sodium-dependent dicarboxylate transporter), member 2	3921	0.12
chr16_91466662_91466825	0.25	Gm49626	predicted gene, 49626	1618	0.17
chr9_118928821_118928982	0.25	Ctdspl	CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like	966	0.46
chr13_91759904_91760091	0.25	Gm27656	predicted gene, 27656	7891	0.15
chr12_18606247_18606408	0.25	Gm48398	predicted gene, 48398	4057	0.19
chr15_58747025_58747176	0.25	Gm20712	predicted gene 20712	34851	0.15
chr4_54905681_54905846	0.25	Zfp462	zinc finger protein 462	39285	0.17
chr1_36075710_36075890	0.25	Hs6st1	heparan sulfate 6-O-sulfotransferase 1	7400	0.15
chr2_170175810_170175971	0.25	Zfp217	zinc finger protein 217	27787	0.23
chr15_6709205_6709602	0.25	Rictor	RPTOR independent companion of MTOR, complex 2	1020	0.58
chr12_86476167_86476343	0.25	Esrrb	estrogen related receptor, beta	6138	0.27
chr15_31062621_31062832	0.25	4930430F21Rik	RIKEN cDNA 4930430F21 gene	23598	0.19
chr1_37491813_37491971	0.25	Gm43213	predicted gene 43213	2910	0.19
chr6_120580202_120580372	0.24	Gm44124	predicted gene, 44124	111	0.95
chr18_39430680_39430864	0.24	Gm15337	predicted gene 15337	41347	0.15
chr13_35616741_35616920	0.24	Gm48707	predicted gene, 48707	43	0.98
chr8_88983561_88983712	0.24	Mir8110	microRNA 8110	41099	0.17

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.1	0.6	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.1	0.2	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1	0.4	GO:0098728	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.1	0.1	GO:0071288	cellular response to mercury ion(GO:0071288)
0.1	0.2	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.1	0.3	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.1	0.3	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.1	0.2	GO:0038161	prolactin signaling pathway(GO:0038161)
0.1	0.2	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.1	0.3	GO:0010825	positive regulation of centrosome duplication(GO:0010825)
0.1	0.2	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.1	0.2	GO:1900740	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.1	0.2	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.1	0.2	GO:2000302	positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.1	0.2	GO:0051684	maintenance of Golgi location(GO:0051684)
0.1	0.2	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.2	GO:0061428	negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.0	0.2	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.1	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.2	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.1	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.1	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.1	GO:0051572	negative regulation of histone H3-K4 methylation(GO:0051572)
0.0	0.2	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.5	GO:0044406	adhesion of symbiont to host(GO:0044406)
0.0	0.1	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.2	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.0	0.1	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.1	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.2	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0051611	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.1	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.2	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0	0.1	GO:1904192	cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.0	0.1	GO:0052203	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0	0.1	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.2	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.1	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0	0.1	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.1	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.0	0.1	GO:1990168	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.0	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.3	GO:0045821	positive regulation of glycolytic process(GO:0045821)
0.0	0.1	GO:0000055	ribosomal large subunit export from nucleus(GO:0000055)
0.0	0.0	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.2	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.2	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.2	GO:0007288	sperm axoneme assembly(GO:0007288)
0.0	0.0	GO:0035905	ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.0	0.1	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.0	0.0	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.2	GO:0046598	positive regulation of viral entry into host cell(GO:0046598)
0.0	0.1	GO:0048386	positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0	0.0	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.1	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.2	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0021886	cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) facioacoustic ganglion development(GO:1903375)
0.0	0.1	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.0	GO:0090310	negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0	0.0	GO:0000189	MAPK import into nucleus(GO:0000189)
0.0	0.0	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.2	GO:0060020	Bergmann glial cell differentiation(GO:0060020)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0030202	heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0	0.0	GO:0002905	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0	0.1	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.1	GO:0043091	L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.0	0.1	GO:0021780	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.1	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.0	GO:0060154	cellular process regulating host cell cycle in response to virus(GO:0060154)
0.0	0.1	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0008065	establishment of blood-nerve barrier(GO:0008065)
0.0	0.1	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.1	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0	0.0	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.1	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0	0.0	GO:0034653	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0061101	neuroendocrine cell differentiation(GO:0061101)
0.0	0.0	GO:2000173	negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0	0.0	GO:0071877	regulation of adrenergic receptor signaling pathway(GO:0071877)
0.0	0.0	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.1	GO:0090232	positive regulation of spindle checkpoint(GO:0090232)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0034627	'de novo' NAD biosynthetic process(GO:0034627)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0097368	establishment of Sertoli cell barrier(GO:0097368)
0.0	0.1	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.0	0.1	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0090170	regulation of Golgi inheritance(GO:0090170)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0033278	cell proliferation in midbrain(GO:0033278)
0.0	0.0	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:0072034	renal vesicle induction(GO:0072034)
0.0	0.0	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
0.0	0.0	GO:0045914	negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
0.0	0.1	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.1	GO:0046110	xanthine catabolic process(GO:0009115) xanthine metabolic process(GO:0046110)
0.0	0.0	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	0.0	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.1	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0021586	pons maturation(GO:0021586)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.1	GO:0006020	inositol metabolic process(GO:0006020)
0.0	0.0	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.0	0.1	GO:0015879	carnitine transport(GO:0015879)
0.0	0.1	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.1	GO:0030836	positive regulation of actin filament depolymerization(GO:0030836)
0.0	0.1	GO:0070932	histone H3 deacetylation(GO:0070932)
0.0	0.0	GO:0045196	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.0	GO:0051661	maintenance of centrosome location(GO:0051661)
0.0	0.0	GO:2000110	negative regulation of macrophage apoptotic process(GO:2000110)
0.0	0.0	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.0	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.0	GO:0060112	generation of ovulation cycle rhythm(GO:0060112)
0.0	0.0	GO:0010482	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0	0.0	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.0	GO:0003100	regulation of systemic arterial blood pressure by endothelin(GO:0003100)
0.0	0.1	GO:0035106	operant conditioning(GO:0035106)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.0	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.2	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.0	GO:2000705	regulation of dense core granule biogenesis(GO:2000705)
0.0	0.0	GO:2000097	regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.0	0.1	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.0	GO:1905065	positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0	0.0	GO:0010025	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0	0.0	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.0	GO:0071332	cellular response to fructose stimulus(GO:0071332)
0.0	0.0	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.2	GO:0035278	miRNA mediated inhibition of translation(GO:0035278)
0.0	0.0	GO:0070314	G1 to G0 transition(GO:0070314)
0.0	0.0	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0051764	actin crosslink formation(GO:0051764)
0.0	0.0	GO:0001834	trophectodermal cell proliferation(GO:0001834)
0.0	0.1	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.0	GO:1903392	negative regulation of adherens junction organization(GO:1903392)
0.0	0.0	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.0	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0	0.0	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0	0.1	GO:0072015	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.0	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0	0.0	GO:0001844	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:0001844)
0.0	0.0	GO:0045626	negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0	0.0	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.0	0.0	GO:0043622	cortical microtubule organization(GO:0043622)
0.0	0.0	GO:0006222	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.1	GO:0006824	cobalt ion transport(GO:0006824)
0.0	0.1	GO:0042136	neurotransmitter biosynthetic process(GO:0042136)
0.0	0.1	GO:0033762	response to glucagon(GO:0033762)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.0	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.0	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.0	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.1	GO:2000821	regulation of grooming behavior(GO:2000821)
0.0	0.1	GO:1905097	regulation of guanyl-nucleotide exchange factor activity(GO:1905097)
0.0	0.0	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.0	GO:0071922	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.0	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.0	GO:0030091	protein repair(GO:0030091)
0.0	0.0	GO:2000195	negative regulation of female gonad development(GO:2000195)
0.0	0.0	GO:0007412	axon target recognition(GO:0007412)
0.0	0.0	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0	0.0	GO:0071394	cellular response to testosterone stimulus(GO:0071394)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.1	0.2	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.2	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.2	GO:0009279	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.4	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.2	GO:0031209	SCAR complex(GO:0031209)
0.0	0.1	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0042585	germinal vesicle(GO:0042585)
0.0	0.1	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0020016	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0097513	myosin II filament(GO:0097513)
0.0	0.1	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.0	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.0	GO:0097427	microtubule bundle(GO:0097427)
0.0	0.0	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.1	GO:0031467	Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.2	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0	0.0	GO:0032010	phagolysosome(GO:0032010)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.1	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.1	GO:0032983	kainate selective glutamate receptor complex(GO:0032983)
0.0	0.0	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.2	GO:0043218	compact myelin(GO:0043218)
0.0	0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0070578	RISC-loading complex(GO:0070578)
0.0	0.1	GO:0044326	dendritic spine neck(GO:0044326)
0.0	0.0	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.0	0.0	GO:0017133	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0	0.1	GO:0000220	vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0	0.3	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.0	GO:1990357	terminal web(GO:1990357)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0043338	CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity(GO:0043338) phospholactate guanylyltransferase activity(GO:0043814) ATP:coenzyme F420 adenylyltransferase activity(GO:0043910) UDP-N-acetylgalactosamine diphosphorylase activity(GO:0052630)
0.1	0.2	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.1	0.2	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0008390	testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.0	0.3	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.2	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.1	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.1	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	0.0	GO:0015137	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.2	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.2	GO:0016886	ligase activity, forming phosphoric ester bonds(GO:0016886)
0.0	0.1	GO:0015157	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0042015	interleukin-20 binding(GO:0042015)
0.0	0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.3	GO:0031994	insulin-like growth factor I binding(GO:0031994)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.1	GO:0071209	U7 snRNA binding(GO:0071209)
0.0	0.1	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.0	GO:0016015	morphogen activity(GO:0016015)
0.0	0.1	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.1	GO:0015199	amino-acid betaine transmembrane transporter activity(GO:0015199) carnitine transmembrane transporter activity(GO:0015226)
0.0	0.1	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0036122	BMP binding(GO:0036122)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.0	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.0	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.0	GO:0019002	GMP binding(GO:0019002)
0.0	0.2	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.1	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.0	0.1	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.0	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0	0.0	GO:0004779	sulfate adenylyltransferase activity(GO:0004779)
0.0	0.0	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.0	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.1	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.1	GO:0003857	3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0	0.1	GO:0004791	thioredoxin-disulfide reductase activity(GO:0004791)
0.0	0.0	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.1	GO:0070883	pre-miRNA binding(GO:0070883)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.0	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	0.0	GO:0019961	interferon binding(GO:0019961)
0.0	0.1	GO:0031748	D1 dopamine receptor binding(GO:0031748)
0.0	0.1	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.0	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.0	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.1	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.0	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.0	GO:0015181	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0	0.0	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.0	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.0	0.2	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
0.0	0.2	GO:0070008	serine-type exopeptidase activity(GO:0070008)
0.0	0.1	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.2	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.1	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.0	GO:0004854	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.0	0.0	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.1	GO:0005247	voltage-gated chloride channel activity(GO:0005247)
0.0	0.0	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.0	GO:0034889	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.0	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	PID ALK2 PATHWAY	ALK2 signaling events
0.2	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	ST G ALPHA S PATHWAY	G alpha s Pathway
0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.1	SA TRKA RECEPTOR	The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.5	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.1	REACTOME INTEGRATION OF ENERGY METABOLISM	Genes involved in Integration of energy metabolism
0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.2	REACTOME REGULATION OF KIT SIGNALING	Genes involved in Regulation of KIT signaling
0.2	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.1	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS	Genes involved in Homologous recombination repair of replication-independent double-strand breaks