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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Foxo6

Z-value: 1.26

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Transcription factors associated with Foxo6

Gene Symbol	Gene ID	Gene Info
Foxo6 Ensembl NCBI MGI UniProt	ENSMUSG00000052135.8	Foxo6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Foxo6	chr4_120283519_120283670	3755	0.255093	0.85	3.3e-02	Click!
Foxo6	chr4_120248926_120249096	38338	0.155782	-0.82	4.4e-02	Click!
Foxo6	chr4_120249226_120249489	37992	0.156568	-0.69	1.3e-01	Click!
Foxo6	chr4_120282848_120282999	4426	0.242435	0.48	3.4e-01	Click!
Foxo6	chr4_120283294_120283461	3972	0.250350	-0.36	4.9e-01	Click!

Activity of the Foxo6 motif across conditions

Conditions sorted by the z-value of the Foxo6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_180200474_180200787	0.68	Coq8a	coenzyme Q8A	1028	0.45
chr8_17783842_17784014	0.68	Csmd1	CUB and Sushi multiple domains 1	248342	0.02
chr2_143993868_143994250	0.67	Rrbp1	ribosome binding protein 1	10894	0.18
chr2_143994492_143994838	0.63	Rrbp1	ribosome binding protein 1	11500	0.18
chr15_87045730_87045890	0.56	Gm23416	predicted gene, 23416	23183	0.18
chr5_89342174_89342864	0.56	Gc	vitamin D binding protein	93109	0.09
chr13_31257761_31257912	0.53	4930401O12Rik	RIKEN cDNA 4930401O12 gene	16750	0.19
chr6_95669064_95669249	0.50	Suclg2	succinate-Coenzyme A ligase, GDP-forming, beta subunit	11688	0.31
chr4_70410998_70411149	0.48	Cdk5rap2	CDK5 regulatory subunit associated protein 2	630	0.84
chr6_117598383_117598541	0.47	Gm45083	predicted gene 45083	14108	0.2
chr15_4836304_4836788	0.47	Gm49074	predicted gene, 49074	10841	0.18
chr12_4220183_4220334	0.47	Gm48210	predicted gene, 48210	1844	0.19
chr8_35390018_35390398	0.47	Ppp1r3b	protein phosphatase 1, regulatory subunit 3B	13548	0.15
chr4_80948759_80948910	0.46	Gm27452	predicted gene, 27452	18610	0.23
chr2_155083519_155083714	0.46	Gm45609	predicted gene 45609	1435	0.33
chr12_4220651_4220920	0.45	Gm48210	predicted gene, 48210	1317	0.27
chr10_59786684_59786837	0.45	Gm17059	predicted gene 17059	13494	0.14
chr10_107289611_107289768	0.43	Lin7a	lin-7 homolog A (C. elegans)	17295	0.24
chr7_63922052_63922218	0.43	Klf13	Kruppel-like factor 13	2735	0.19
chr6_121844056_121844207	0.42	Mug1	murinoglobulin 1	3027	0.29
chr6_140197945_140198178	0.41	Gm24174	predicted gene, 24174	31416	0.16
chr9_67830526_67830677	0.40	C2cd4a	C2 calcium-dependent domain containing 4A	1729	0.35
chr11_69094794_69095306	0.38	Per1	period circadian clock 1	167	0.86
chr9_112103407_112103804	0.38	Mir128-2	microRNA 128-2	15106	0.26
chr5_140129593_140129908	0.38	Mad1l1	MAD1 mitotic arrest deficient 1-like 1	14284	0.15
chr19_39005964_39006115	0.37	Cyp2c55	cytochrome P450, family 2, subfamily c, polypeptide 55	980	0.38
chr12_52470605_52470777	0.37	Gm35135	predicted gene, 35135	9918	0.19
chr9_62355640_62355873	0.37	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	10957	0.2
chr3_36481808_36481975	0.37	1810062G17Rik	RIKEN cDNA 1810062G17 gene	5954	0.12
chr18_12023718_12023871	0.37	Tmem241	transmembrane protein 241	50837	0.13
chr1_67207008_67207510	0.37	Gm15668	predicted gene 15668	41941	0.15
chr6_113440512_113440730	0.37	Gm43928	predicted gene, 43928	273	0.75
chr10_111389057_111389255	0.37	Gm40761	predicted gene, 40761	52032	0.11
chr19_4878250_4878444	0.36	Zdhhc24	zinc finger, DHHC domain containing 24	321	0.53
chr6_57543051_57543249	0.36	Ppm1k	protein phosphatase 1K (PP2C domain containing)	7682	0.16
chr17_46723600_46724031	0.36	Gnmt	glycine N-methyltransferase	2887	0.12
chr9_101182262_101182439	0.35	Gm38344	predicted gene, 38344	5558	0.13
chr2_155378850_155379039	0.35	Trp53inp2	transformation related protein 53 inducible nuclear protein 2	2115	0.23
chr10_20486313_20486464	0.34	Gm17229	predicted gene 17229	31776	0.16
chr9_103217995_103218146	0.34	Trf	transferrin	1796	0.31
chr15_9093874_9094049	0.34	Nadk2	NAD kinase 2, mitochondrial	686	0.72
chr4_104768550_104768721	0.34	C8b	complement component 8, beta polypeptide	2240	0.4
chr2_59130808_59130980	0.34	Gm13550	predicted gene 13550	17729	0.19
chr3_144285992_144286165	0.33	Gm43446	predicted gene 43446	2267	0.32
chr9_95567560_95567711	0.33	Paqr9	progestin and adipoQ receptor family member IX	7978	0.14
chr2_109757612_109757763	0.33	Gm13932	predicted gene 13932	34847	0.16
chr19_37887154_37887305	0.33	Myof	myoferlin	14274	0.19
chr2_31519719_31520357	0.33	Ass1	argininosuccinate synthetase 1	1548	0.36
chr12_79441750_79441941	0.32	Rad51b	RAD51 paralog B	114492	0.06
chr5_51799710_51799877	0.32	Gm43606	predicted gene 43606	58982	0.12
chr8_22858612_22858763	0.32	Kat6a	K(lysine) acetyltransferase 6A	848	0.54
chr9_31209643_31210005	0.32	Aplp2	amyloid beta (A4) precursor-like protein 2	1963	0.34
chr3_107974136_107974298	0.32	Gstm3	glutathione S-transferase, mu 3	4934	0.08
chr1_187315684_187315899	0.32	Gm38155	predicted gene, 38155	61678	0.11
chr14_21336208_21336382	0.32	Adk	adenosine kinase	18170	0.25
chr5_121334351_121334559	0.32	Hectd4	HECT domain E3 ubiquitin protein ligase 4	14432	0.12
chr17_5017691_5017888	0.32	Arid1b	AT rich interactive domain 1B (SWI-like)	21360	0.22
chr5_145858255_145858504	0.31	Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	18312	0.15
chr8_33886292_33886477	0.31	Gm26978	predicted gene, 26978	637	0.69
chr11_78105085_78105236	0.31	Fam222b	family with sequence similarity 222, member B	10446	0.08
chr8_35387028_35387898	0.30	Ppp1r3b	protein phosphatase 1, regulatory subunit 3B	10803	0.16
chr13_34154072_34154234	0.30	Psmg4	proteasome (prosome, macropain) assembly chaperone 4	8811	0.12
chr2_71254564_71254716	0.30	Dync1i2	dynein cytoplasmic 1 intermediate chain 2	5907	0.22
chr15_35886635_35886786	0.30	Vps13b	vacuolar protein sorting 13B	14988	0.16
chr8_108789308_108789477	0.29	Gm38042	predicted gene, 38042	51799	0.14
chr15_36335633_36335784	0.29	Gm33936	predicted gene, 33936	14046	0.12
chr4_11612532_11612699	0.29	Gm11832	predicted gene 11832	2392	0.23
chr16_93875336_93875598	0.29	Chaf1b	chromatin assembly factor 1, subunit B (p60)	8434	0.13
chr4_148060264_148060415	0.29	Mthfr	methylenetetrahydrofolate reductase	7661	0.09
chr13_113023428_113023726	0.29	Cdc20b	cell division cycle 20B	11534	0.08
chr3_95435996_95436155	0.28	Arnt	aryl hydrocarbon receptor nuclear translocator	1556	0.21
chr14_73383648_73383821	0.28	Itm2b	integral membrane protein 2B	1464	0.43
chr5_28056784_28057184	0.28	Gm26608	predicted gene, 26608	1525	0.35
chr4_52517213_52517398	0.28	Vma21-ps	VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene	20061	0.19
chr13_9014068_9014362	0.28	Gtpbp4	GTP binding protein 4	18132	0.1
chr6_121143927_121144113	0.28	Mical3	microtubule associated monooxygenase, calponin and LIM domain containing 3	13021	0.14
chr15_73394628_73394911	0.28	Ptk2	PTK2 protein tyrosine kinase 2	70	0.97
chr2_69336183_69336378	0.27	Abcb11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	6320	0.19
chr1_140173150_140173301	0.27	Cfh	complement component factor h	10055	0.24
chr18_32557156_32557525	0.27	Gypc	glycophorin C	2640	0.3
chr13_41214741_41215042	0.27	Elovl2	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	5271	0.14
chr15_100604875_100605219	0.27	Gm49492	predicted gene, 49492	4843	0.09
chr1_67200520_67200671	0.27	Gm15668	predicted gene 15668	48605	0.14
chr15_80674781_80675071	0.27	Fam83f	family with sequence similarity 83, member F	3079	0.17
chr11_8523561_8523765	0.27	Tns3	tensin 3	21688	0.27
chr6_147954211_147954549	0.27	Far2	fatty acyl CoA reductase 2	92879	0.07
chrX_103820422_103820573	0.26	Slc16a2	solute carrier family 16 (monocarboxylic acid transporters), member 2	1486	0.35
chr1_171216477_171216936	0.26	Nr1i3	nuclear receptor subfamily 1, group I, member 3	2357	0.12
chr8_40882534_40882732	0.26	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	7685	0.16
chr4_97789633_97790009	0.26	E130114P18Rik	RIKEN cDNA E130114P18 gene	11743	0.2
chr4_97933124_97933499	0.26	Nfia	nuclear factor I/A	22278	0.26
chr11_120674778_120674973	0.26	Aspscr1	alveolar soft part sarcoma chromosome region, candidate 1 (human)	1471	0.16
chr15_67420672_67420895	0.26	1700012I11Rik	RIKEN cDNA 1700012I11 gene	194014	0.03
chr19_55566077_55566254	0.26	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	175655	0.03
chr13_34735060_34735220	0.26	Fam50b	family with sequence similarity 50, member B	290	0.85
chr9_101093226_101093396	0.26	Gm37553	predicted gene, 37553	334	0.81
chr4_84619745_84620056	0.26	Bnc2	basonuclin 2	55096	0.15
chr6_128132951_128133168	0.25	Tspan9	tetraspanin 9	3650	0.16
chr14_89611447_89611598	0.25	Gm25415	predicted gene, 25415	95283	0.09
chr10_110706552_110706703	0.25	E2f7	E2F transcription factor 7	38812	0.16
chr10_68103006_68103157	0.25	Arid5b	AT rich interactive domain 5B (MRF1-like)	33545	0.18
chr3_81674937_81675101	0.25	Gm43346	predicted gene 43346	46657	0.17
chr9_70278042_70278225	0.25	Myo1e	myosin IE	70765	0.09
chr6_140440823_140441093	0.25	Plekha5	pleckstrin homology domain containing, family A member 5	7969	0.22
chr15_76251124_76251290	0.25	Mir6953	microRNA 6953	3016	0.09
chr2_75668710_75668893	0.25	Hnrnpa3	heterogeneous nuclear ribonucleoprotein A3	6312	0.13
chr4_145087410_145087580	0.25	Vps13d	vacuolar protein sorting 13D	4455	0.3
chr6_72609129_72609280	0.25	Gm20536	predicted gene 20536	632	0.48
chr18_44785957_44786151	0.25	Mcc	mutated in colorectal cancers	26128	0.15
chr6_116064213_116064364	0.25	Tmcc1	transmembrane and coiled coil domains 1	6239	0.19
chr9_74979549_74979946	0.24	Fam214a	family with sequence similarity 214, member A	3636	0.24
chr11_4123188_4123541	0.24	Sec14l2	SEC14-like lipid binding 2	51	0.94
chr2_6402913_6403256	0.24	Usp6nl	USP6 N-terminal like	17838	0.18
chr16_13306126_13306394	0.24	Mrtfb	myocardin related transcription factor B	41184	0.16
chr5_25227061_25227222	0.24	E130116L18Rik	RIKEN cDNA E130116L18 gene	3988	0.18
chr7_143052216_143052572	0.24	Cd81	CD81 antigen	345	0.72
chr5_44239117_44239268	0.24	Tapt1	transmembrane anterior posterior transformation 1	12566	0.11
chr10_21448600_21448779	0.24	Gm48386	predicted gene, 48386	3053	0.2
chr14_51064256_51064407	0.24	Rnase12	ribonuclease, RNase A family, 12 (non-active)	6670	0.08
chr8_95432921_95433173	0.24	Cfap20	cilia and flagella associated protein 20	1710	0.27
chr4_106331582_106331733	0.24	Usp24	ubiquitin specific peptidase 24	15423	0.16
chr7_136493461_136493612	0.24	Gm36849	predicted gene, 36849	140172	0.04
chr17_31872001_31872152	0.24	Sik1	salt inducible kinase 1	16272	0.13
chr14_70393462_70393631	0.24	Gm22725	predicted gene, 22725	28734	0.08
chr15_62394159_62394346	0.24	Pvt1	Pvt1 oncogene	171649	0.03
chr3_108770957_108771116	0.23	Aknad1	AKNA domain containing 1	10822	0.15
chr1_194425856_194426037	0.23	Plxna2	plexin A2	192272	0.03
chr14_120498503_120498675	0.23	Rap2a	RAS related protein 2a	20145	0.24
chr11_116108287_116108624	0.23	Trim47	tripartite motif-containing 47	336	0.77
chr4_12237364_12237535	0.23	Gm11847	predicted gene 11847	4616	0.22
chr11_119986483_119986646	0.23	Baiap2	brain-specific angiogenesis inhibitor 1-associated protein 2	11107	0.11
chr16_37588570_37588721	0.23	Gm46559	predicted gene, 46559	7545	0.15
chr7_66083686_66083837	0.23	Selenos	selenoprotein S	3800	0.14
chr8_33867033_33867186	0.23	Rbpms	RNA binding protein gene with multiple splicing	13436	0.16
chr2_103177688_103177876	0.23	Gm13874	predicted gene 13874	5	0.98
chr4_47366562_47366857	0.23	Tgfbr1	transforming growth factor, beta receptor I	13099	0.22
chr7_113778913_113779066	0.23	Spon1	spondin 1, (f-spondin) extracellular matrix protein	12815	0.22
chr6_71837905_71838056	0.23	Gm44771	predicted gene 44771	6270	0.11
chr11_109926883_109927034	0.23	Gm11697	predicted gene 11697	9358	0.22
chr13_36533643_36534408	0.23	Fars2	phenylalanine-tRNA synthetase 2 (mitochondrial)	3072	0.22
chr4_49491887_49492038	0.23	Baat	bile acid-Coenzyme A: amino acid N-acyltransferase	11158	0.12
chr13_117744891_117745098	0.23	4933413L06Rik	RIKEN cDNA 4933413L06 gene	24983	0.26
chr10_69205623_69205774	0.23	Rhobtb1	Rho-related BTB domain containing 1	2854	0.25
chr4_90495794_90495984	0.23	Gm12635	predicted gene 12635	43015	0.17
chr9_118044918_118045069	0.22	Azi2	5-azacytidine induced gene 2	4306	0.22
chr7_127214965_127215278	0.22	Septin1	septin 1	4	0.92
chr6_42251921_42252091	0.22	Gstk1	glutathione S-transferase kappa 1	5983	0.11
chr4_6265892_6266043	0.22	Gm11798	predicted gene 11798	5002	0.21
chr3_10304842_10305071	0.22	A930014E01Rik	RIKEN cDNA A930014E01 gene	165	0.9
chr16_58728459_58728625	0.22	Cldnd1	claudin domain containing 1	494	0.67
chr11_104539702_104539853	0.22	Cdc27	cell division cycle 27	10615	0.11
chr7_142533086_142533550	0.22	Mrpl23	mitochondrial ribosomal protein L23	156	0.91
chr4_99046271_99046475	0.22	Dock7	dedicator of cytokinesis 7	8960	0.18
chr13_34650669_34650865	0.22	Pxdc1	PX domain containing 1	1914	0.22
chr1_88006329_88006480	0.22	Usp40	ubiquitin specific peptidase 40	1825	0.18
chr1_30941324_30941475	0.22	Ptp4a1	protein tyrosine phosphatase 4a1	2905	0.22
chr2_103598963_103599142	0.21	Abtb2	ankyrin repeat and BTB (POZ) domain containing 2	32742	0.16
chr14_21033435_21033611	0.21	Vcl	vinculin	11520	0.18
chr5_45430764_45431089	0.21	Gm42413	predicted gene, 42413	3463	0.17
chr10_40297176_40297522	0.21	Amd1	S-adenosylmethionine decarboxylase 1	4227	0.13
chr2_35103269_35103589	0.21	AI182371	expressed sequence AI182371	1886	0.29
chr3_81997803_81997954	0.21	Asic5	acid-sensing (proton-gated) ion channel family member 5	956	0.53
chr9_57439182_57439333	0.21	Ppcdc	phosphopantothenoylcysteine decarboxylase	834	0.49
chr14_17696257_17696429	0.21	Thrb	thyroid hormone receptor beta	35447	0.21
chr1_74901365_74901516	0.21	Mir375	microRNA 375	719	0.39
chr2_67881464_67881701	0.21	Gm37964	predicted gene, 37964	17014	0.24
chr13_90359772_90359986	0.21	Gm37708	predicted gene, 37708	26678	0.21
chr10_81091333_81091491	0.21	Creb3l3	cAMP responsive element binding protein 3-like 3	494	0.58
chr4_132997648_132997799	0.21	Ahdc1	AT hook, DNA binding motif, containing 1	13537	0.16
chr7_102293168_102293449	0.21	Stim1	stromal interaction molecule 1	24981	0.12
chr5_115018762_115018913	0.21	Sppl3	signal peptide peptidase 3	7340	0.1
chr6_127108825_127109062	0.21	Tigar	Trp53 induced glycolysis regulatory phosphatase	607	0.6
chr4_101282048_101282334	0.21	Gm12801	predicted gene 12801	2030	0.22
chr2_31484723_31485077	0.21	Ass1	argininosuccinate synthetase 1	12872	0.18
chr12_30341867_30342052	0.21	Sntg2	syntrophin, gamma 2	15724	0.25
chr19_32807644_32807795	0.21	Pten	phosphatase and tensin homolog	3506	0.32
chr15_62112429_62112580	0.21	Pvt1	Pvt1 oncogene	13475	0.27
chr6_145793553_145793704	0.21	Rassf8	Ras association (RalGDS/AF-6) domain family (N-terminal) member 8	14755	0.19
chr10_31650590_31650759	0.21	Gm8793	predicted gene 8793	11516	0.21
chr17_83181717_83182272	0.20	Pkdcc	protein kinase domain containing, cytoplasmic	33298	0.17
chr12_34238298_34238489	0.20	Gm18025	predicted gene, 18025	52742	0.18
chr11_73048783_73048934	0.20	Ncbp3	nuclear cap binding subunit 3	985	0.43
chr3_135675431_135675674	0.20	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	6213	0.21
chr16_95139892_95140046	0.20	Gm49642	predicted gene, 49642	31541	0.18
chr5_72883801_72883981	0.20	Tec	tec protein tyrosine kinase	15408	0.14
chr2_178680469_178680632	0.20	Cdh26	cadherin-like 26	219920	0.02
chr12_102271886_102272090	0.20	Rin3	Ras and Rab interactor 3	11060	0.21
chr11_78103949_78104116	0.20	Fam222b	family with sequence similarity 222, member B	9324	0.08
chr6_139875525_139875713	0.20	Pik3c2g	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma	31971	0.17
chr11_34834139_34834311	0.20	Spdl1	spindle apparatus coiled-coil protein 1	584	0.74
chr17_50544760_50544923	0.20	Plcl2	phospholipase C-like 2	35438	0.22
chr16_33222596_33222759	0.20	Osbpl11	oxysterol binding protein-like 11	1921	0.33
chr15_84412819_84412970	0.19	Shisal1	shisa like 1	30803	0.16
chr1_21262754_21263025	0.19	Gm28836	predicted gene 28836	8704	0.11
chr10_127082531_127082956	0.19	Agap2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2	3836	0.09
chr2_75722764_75722925	0.19	Gm13656	predicted gene 13656	7328	0.13
chr1_151325474_151325655	0.19	Gm10138	predicted gene 10138	18518	0.13
chr8_44971130_44971287	0.19	Fat1	FAT atypical cadherin 1	20994	0.18
chr10_84885783_84886161	0.19	Ric8b	RIC8 guanine nucleotide exchange factor B	31644	0.17
chr15_80680833_80681008	0.19	Fam83f	family with sequence similarity 83, member F	9073	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0010046	response to mycotoxin(GO:0010046)
0.1	0.3	GO:0097167	circadian regulation of translation(GO:0097167)
0.1	0.2	GO:0006741	NADP biosynthetic process(GO:0006741)
0.1	0.2	GO:1904023	regulation of fermentation(GO:0043465) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.1	0.3	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.1	0.2	GO:0071336	regulation of hair follicle cell proliferation(GO:0071336)
0.1	0.2	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.1	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0	0.2	GO:0090188	negative regulation of pancreatic juice secretion(GO:0090188)
0.0	0.1	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.1	GO:0006548	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.2	GO:0090209	negative regulation of triglyceride metabolic process(GO:0090209)
0.0	0.3	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.3	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.1	GO:0034975	protein folding in endoplasmic reticulum(GO:0034975)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.0	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.2	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.1	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.2	GO:0005981	regulation of glycogen catabolic process(GO:0005981)
0.0	0.1	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.0	GO:1901421	positive regulation of response to alcohol(GO:1901421)
0.0	0.1	GO:0008355	olfactory learning(GO:0008355)
0.0	0.1	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0070640	vitamin D3 metabolic process(GO:0070640)
0.0	0.1	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.1	GO:0090611	ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0	0.1	GO:1904016	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.1	GO:0015819	lysine transport(GO:0015819)
0.0	0.2	GO:0043651	linoleic acid metabolic process(GO:0043651)
0.0	0.1	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0	0.1	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.1	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0	0.1	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.0	0.1	GO:0010956	negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.0	0.1	GO:0071265	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.1	GO:0072396	response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0	0.1	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.0	0.1	GO:0034501	protein localization to kinetochore(GO:0034501)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0010901	regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:1990440	positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0	0.1	GO:1903204	negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0	0.1	GO:0010873	positive regulation of cholesterol esterification(GO:0010873)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.0	GO:0032430	positive regulation of phospholipase A2 activity(GO:0032430)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.1	GO:0010890	positive regulation of sequestering of triglyceride(GO:0010890)
0.0	0.1	GO:0042738	exogenous drug catabolic process(GO:0042738)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.1	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.0	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.0	GO:0002155	regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0002439	chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0	0.0	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.0	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.0	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.0	GO:0070212	protein poly-ADP-ribosylation(GO:0070212)
0.0	0.1	GO:0006370	7-methylguanosine mRNA capping(GO:0006370)
0.0	0.2	GO:0006999	nuclear pore organization(GO:0006999)
0.0	0.1	GO:0008295	spermidine biosynthetic process(GO:0008295)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:2000188	regulation of cholesterol homeostasis(GO:2000188)
0.0	0.1	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0	0.1	GO:0060295	regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0	0.0	GO:0060468	prevention of polyspermy(GO:0060468)
0.0	0.0	GO:1900020	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.1	GO:1901317	regulation of sperm motility(GO:1901317)
0.0	0.1	GO:1990564	protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0	0.0	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.1	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.2	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	0.0	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.1	GO:0006555	methionine metabolic process(GO:0006555)
0.0	0.0	GO:0002154	thyroid hormone mediated signaling pathway(GO:0002154)
0.0	0.0	GO:1902965	regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0	0.0	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.0	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.0	GO:0035973	aggrephagy(GO:0035973)
0.0	0.0	GO:0002018	renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0	0.1	GO:0051561	positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.0	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0	0.0	GO:0018243	protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0060213	regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0	0.0	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0005579	membrane attack complex(GO:0005579)
0.2	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.2	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.4	GO:0097431	mitotic spindle pole(GO:0097431)
0.1	GO:0097413	Lewy body(GO:0097413)
0.2	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.1	GO:0000322	storage vacuole(GO:0000322)
0.1	GO:1990246	uniplex complex(GO:1990246)
0.2	GO:0070852	cell body fiber(GO:0070852)
0.1	GO:0005955	calcineurin complex(GO:0005955)
0.1	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.2	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.1	GO:0000796	condensin complex(GO:0000796)
0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.1	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.1	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.4	GO:0016592	mediator complex(GO:0016592)
0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.1	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.1	GO:0089701	U2AF(GO:0089701)
0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
0.0	GO:0031094	platelet dense tubular network(GO:0031094)
0.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.1	GO:0090543	Flemming body(GO:0090543)
0.0	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.1	GO:0097016	L27 domain binding(GO:0097016)
0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.1	GO:0043515	kinetochore binding(GO:0043515)
0.2	GO:1990459	transferrin receptor binding(GO:1990459)
0.1	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.1	GO:0008142	oxysterol binding(GO:0008142)
0.2	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.1	GO:0004083	bisphosphoglycerate 2-phosphatase activity(GO:0004083)
0.1	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.3	GO:0015643	toxic substance binding(GO:0015643)
0.2	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.1	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.3	GO:0008432	JUN kinase binding(GO:0008432)
0.1	GO:0016841	ammonia-lyase activity(GO:0016841)
0.1	GO:0070191	methionine-R-sulfoxide reductase activity(GO:0070191)
0.1	GO:0004667	prostaglandin-D synthase activity(GO:0004667)
0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.1	GO:0030620	U2 snRNA binding(GO:0030620)
0.1	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.1	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.1	GO:0016623	aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.1	GO:0051022	Rho GDP-dissociation inhibitor binding(GO:0051022)
0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1	GO:0015181	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.1	GO:0035473	lipase binding(GO:0035473)
0.3	GO:0046966	thyroid hormone receptor binding(GO:0046966)
0.1	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	GO:0032190	acrosin binding(GO:0032190)
0.1	GO:0035497	cAMP response element binding(GO:0035497)
0.1	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	GO:0042809	vitamin D receptor binding(GO:0042809)
0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	GO:0016812	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.1	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	GO:0097109	neuroligin family protein binding(GO:0097109)
0.1	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	GO:0034235	GPI anchor binding(GO:0034235)
0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.3	GO:0070888	E-box binding(GO:0070888)
0.0	GO:0031781	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.0	GO:0102007	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.5	ST GA13 PATHWAY	G alpha 13 Pathway
0.0	PID CD40 PATHWAY	CD40/CD40L signaling
0.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.5	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.1	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.2	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10	Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.1	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation