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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for Foxo6

Z-value: 1.26

Motif logo

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Transcription factors associated with Foxo6

Gene Symbol Gene ID Gene Info
Foxo6
ENSMUSG00000052135.8 forkhead box O6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr4_120283519_120283670Foxo637550.2550930.853.3e-02Click!
chr4_120248926_120249096Foxo6383380.155782-0.824.4e-02Click!
chr4_120249226_120249489Foxo6379920.156568-0.691.3e-01Click!
chr4_120282848_120282999Foxo644260.2424350.483.4e-01Click!
chr4_120283294_120283461Foxo639720.250350-0.364.9e-01Click!

Activity of the Foxo6 motif across conditions

Conditions sorted by the z-value of the Foxo6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr1_180200474_180200787 0.68 Coq8a
 coenzyme Q8A
 1028
 0.45
chr8_17783842_17784014 0.68 Csmd1
 CUB and Sushi multiple domains 1
 248342
 0.02
chr2_143993868_143994250 0.67 Rrbp1
 ribosome binding protein 1
 10894
 0.18
chr2_143994492_143994838 0.63 Rrbp1
 ribosome binding protein 1
 11500
 0.18
chr15_87045730_87045890 0.56 Gm23416
 predicted gene, 23416
 23183
 0.18
chr5_89342174_89342864 0.56 Gc
 vitamin D binding protein
 93109
 0.09
chr13_31257761_31257912 0.53 4930401O12Rik
 RIKEN cDNA 4930401O12 gene
 16750
 0.19
chr6_95669064_95669249 0.50 Suclg2
 succinate-Coenzyme A ligase, GDP-forming, beta subunit
 11688
 0.31
chr4_70410998_70411149 0.48 Cdk5rap2
 CDK5 regulatory subunit associated protein 2
 630
 0.84
chr6_117598383_117598541 0.47 Gm45083
 predicted gene 45083
 14108
 0.2
chr15_4836304_4836788 0.47 Gm49074
 predicted gene, 49074
 10841
 0.18
chr12_4220183_4220334 0.47 Gm48210
 predicted gene, 48210
 1844
 0.19
chr8_35390018_35390398 0.47 Ppp1r3b
 protein phosphatase 1, regulatory subunit 3B
 13548
 0.15
chr4_80948759_80948910 0.46 Gm27452
 predicted gene, 27452
 18610
 0.23
chr2_155083519_155083714 0.46 Gm45609
 predicted gene 45609
 1435
 0.33
chr12_4220651_4220920 0.45 Gm48210
 predicted gene, 48210
 1317
 0.27
chr10_59786684_59786837 0.45 Gm17059
 predicted gene 17059
 13494
 0.14
chr10_107289611_107289768 0.43 Lin7a
 lin-7 homolog A (C. elegans)
 17295
 0.24
chr7_63922052_63922218 0.43 Klf13
 Kruppel-like factor 13
 2735
 0.19
chr6_121844056_121844207 0.42 Mug1
 murinoglobulin 1
 3027
 0.29
chr6_140197945_140198178 0.41 Gm24174
 predicted gene, 24174
 31416
 0.16
chr9_67830526_67830677 0.40 C2cd4a
 C2 calcium-dependent domain containing 4A
 1729
 0.35
chr11_69094794_69095306 0.38 Per1
 period circadian clock 1
 167
 0.86
chr9_112103407_112103804 0.38 Mir128-2
 microRNA 128-2
 15106
 0.26
chr5_140129593_140129908 0.38 Mad1l1
 MAD1 mitotic arrest deficient 1-like 1
 14284
 0.15
chr19_39005964_39006115 0.37 Cyp2c55
 cytochrome P450, family 2, subfamily c, polypeptide 55
 980
 0.38
chr12_52470605_52470777 0.37 Gm35135
 predicted gene, 35135
 9918
 0.19
chr9_62355640_62355873 0.37 Anp32a
 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A
 10957
 0.2
chr3_36481808_36481975 0.37 1810062G17Rik
 RIKEN cDNA 1810062G17 gene
 5954
 0.12
chr18_12023718_12023871 0.37 Tmem241
 transmembrane protein 241
 50837
 0.13
chr1_67207008_67207510 0.37 Gm15668
 predicted gene 15668
 41941
 0.15
chr6_113440512_113440730 0.37 Gm43928
 predicted gene, 43928
 273
 0.75
chr10_111389057_111389255 0.37 Gm40761
 predicted gene, 40761
 52032
 0.11
chr19_4878250_4878444 0.36 Zdhhc24
 zinc finger, DHHC domain containing 24
 321
 0.53
chr6_57543051_57543249 0.36 Ppm1k
 protein phosphatase 1K (PP2C domain containing)
 7682
 0.16
chr17_46723600_46724031 0.36 Gnmt
 glycine N-methyltransferase
 2887
 0.12
chr9_101182262_101182439 0.35 Gm38344
 predicted gene, 38344
 5558
 0.13
chr2_155378850_155379039 0.35 Trp53inp2
 transformation related protein 53 inducible nuclear protein 2
 2115
 0.23
chr10_20486313_20486464 0.34 Gm17229
 predicted gene 17229
 31776
 0.16
chr9_103217995_103218146 0.34 Trf
 transferrin
 1796
 0.31
chr15_9093874_9094049 0.34 Nadk2
 NAD kinase 2, mitochondrial
 686
 0.72
chr4_104768550_104768721 0.34 C8b
 complement component 8, beta polypeptide
 2240
 0.4
chr2_59130808_59130980 0.34 Gm13550
 predicted gene 13550
 17729
 0.19
chr3_144285992_144286165 0.33 Gm43446
 predicted gene 43446
 2267
 0.32
chr9_95567560_95567711 0.33 Paqr9
 progestin and adipoQ receptor family member IX
 7978
 0.14
chr2_109757612_109757763 0.33 Gm13932
 predicted gene 13932
 34847
 0.16
chr19_37887154_37887305 0.33 Myof
 myoferlin
 14274
 0.19
chr2_31519719_31520357 0.33 Ass1
 argininosuccinate synthetase 1
 1548
 0.36
chr12_79441750_79441941 0.32 Rad51b
 RAD51 paralog B
 114492
 0.06
chr5_51799710_51799877 0.32 Gm43606
 predicted gene 43606
 58982
 0.12
chr8_22858612_22858763 0.32 Kat6a
 K(lysine) acetyltransferase 6A
 848
 0.54
chr9_31209643_31210005 0.32 Aplp2
 amyloid beta (A4) precursor-like protein 2
 1963
 0.34
chr3_107974136_107974298 0.32 Gstm3
 glutathione S-transferase, mu 3
 4934
 0.08
chr1_187315684_187315899 0.32 Gm38155
 predicted gene, 38155
 61678
 0.11
chr14_21336208_21336382 0.32 Adk
 adenosine kinase
 18170
 0.25
chr5_121334351_121334559 0.32 Hectd4
 HECT domain E3 ubiquitin protein ligase 4
 14432
 0.12
chr17_5017691_5017888 0.32 Arid1b
 AT rich interactive domain 1B (SWI-like)
 21360
 0.22
chr5_145858255_145858504 0.31 Cyp3a11
 cytochrome P450, family 3, subfamily a, polypeptide 11
 18312
 0.15
chr8_33886292_33886477 0.31 Gm26978
 predicted gene, 26978
 637
 0.69
chr11_78105085_78105236 0.31 Fam222b
 family with sequence similarity 222, member B
 10446
 0.08
chr8_35387028_35387898 0.30 Ppp1r3b
 protein phosphatase 1, regulatory subunit 3B
 10803
 0.16
chr13_34154072_34154234 0.30 Psmg4
 proteasome (prosome, macropain) assembly chaperone 4
 8811
 0.12
chr2_71254564_71254716 0.30 Dync1i2
 dynein cytoplasmic 1 intermediate chain 2
 5907
 0.22
chr15_35886635_35886786 0.30 Vps13b
 vacuolar protein sorting 13B
 14988
 0.16
chr8_108789308_108789477 0.29 Gm38042
 predicted gene, 38042
 51799
 0.14
chr15_36335633_36335784 0.29 Gm33936
 predicted gene, 33936
 14046
 0.12
chr4_11612532_11612699 0.29 Gm11832
 predicted gene 11832
 2392
 0.23
chr16_93875336_93875598 0.29 Chaf1b
 chromatin assembly factor 1, subunit B (p60)
 8434
 0.13
chr4_148060264_148060415 0.29 Mthfr
 methylenetetrahydrofolate reductase
 7661
 0.09
chr13_113023428_113023726 0.29 Cdc20b
 cell division cycle 20B
 11534
 0.08
chr3_95435996_95436155 0.28 Arnt
 aryl hydrocarbon receptor nuclear translocator
 1556
 0.21
chr14_73383648_73383821 0.28 Itm2b
 integral membrane protein 2B
 1464
 0.43
chr5_28056784_28057184 0.28 Gm26608
 predicted gene, 26608
 1525
 0.35
chr4_52517213_52517398 0.28 Vma21-ps
 VMA21 vacuolar H+-ATPase homolog (S. cerevisiae), pseudogene
 20061
 0.19
chr13_9014068_9014362 0.28 Gtpbp4
 GTP binding protein 4
 18132
 0.1
chr6_121143927_121144113 0.28 Mical3
 microtubule associated monooxygenase, calponin and LIM domain containing 3
 13021
 0.14
chr15_73394628_73394911 0.28 Ptk2
 PTK2 protein tyrosine kinase 2
 70
 0.97
chr2_69336183_69336378 0.27 Abcb11
 ATP-binding cassette, sub-family B (MDR/TAP), member 11
 6320
 0.19
chr1_140173150_140173301 0.27 Cfh
 complement component factor h
 10055
 0.24
chr18_32557156_32557525 0.27 Gypc
 glycophorin C
 2640
 0.3
chr13_41214741_41215042 0.27 Elovl2
 elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2
 5271
 0.14
chr15_100604875_100605219 0.27 Gm49492
 predicted gene, 49492
 4843
 0.09
chr1_67200520_67200671 0.27 Gm15668
 predicted gene 15668
 48605
 0.14
chr15_80674781_80675071 0.27 Fam83f
 family with sequence similarity 83, member F
 3079
 0.17
chr11_8523561_8523765 0.27 Tns3
 tensin 3
 21688
 0.27
chr6_147954211_147954549 0.27 Far2
 fatty acyl CoA reductase 2
 92879
 0.07
chrX_103820422_103820573 0.26 Slc16a2
 solute carrier family 16 (monocarboxylic acid transporters), member 2
 1486
 0.35
chr1_171216477_171216936 0.26 Nr1i3
 nuclear receptor subfamily 1, group I, member 3
 2357
 0.12
chr8_40882534_40882732 0.26 Slc7a2
 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2
 7685
 0.16
chr4_97789633_97790009 0.26 E130114P18Rik
 RIKEN cDNA E130114P18 gene
 11743
 0.2
chr4_97933124_97933499 0.26 Nfia
 nuclear factor I/A
 22278
 0.26
chr11_120674778_120674973 0.26 Aspscr1
 alveolar soft part sarcoma chromosome region, candidate 1 (human)
 1471
 0.16
chr15_67420672_67420895 0.26 1700012I11Rik
 RIKEN cDNA 1700012I11 gene
 194014
 0.03
chr19_55566077_55566254 0.26 Tcf7l2
 transcription factor 7 like 2, T cell specific, HMG box
 175655
 0.03
chr13_34735060_34735220 0.26 Fam50b
 family with sequence similarity 50, member B
 290
 0.85
chr9_101093226_101093396 0.26 Gm37553
 predicted gene, 37553
 334
 0.81
chr4_84619745_84620056 0.26 Bnc2
 basonuclin 2
 55096
 0.15
chr6_128132951_128133168 0.25 Tspan9
 tetraspanin 9
 3650
 0.16
chr14_89611447_89611598 0.25 Gm25415
 predicted gene, 25415
 95283
 0.09
chr10_110706552_110706703 0.25 E2f7
 E2F transcription factor 7
 38812
 0.16
chr10_68103006_68103157 0.25 Arid5b
 AT rich interactive domain 5B (MRF1-like)
 33545
 0.18
chr3_81674937_81675101 0.25 Gm43346
 predicted gene 43346
 46657
 0.17
chr9_70278042_70278225 0.25 Myo1e
 myosin IE
 70765
 0.09
chr6_140440823_140441093 0.25 Plekha5
 pleckstrin homology domain containing, family A member 5
 7969
 0.22
chr15_76251124_76251290 0.25 Mir6953
 microRNA 6953
 3016
 0.09
chr2_75668710_75668893 0.25 Hnrnpa3
 heterogeneous nuclear ribonucleoprotein A3
 6312
 0.13
chr4_145087410_145087580 0.25 Vps13d
 vacuolar protein sorting 13D
 4455
 0.3
chr6_72609129_72609280 0.25 Gm20536
 predicted gene 20536
 632
 0.48
chr18_44785957_44786151 0.25 Mcc
 mutated in colorectal cancers
 26128
 0.15
chr6_116064213_116064364 0.25 Tmcc1
 transmembrane and coiled coil domains 1
 6239
 0.19
chr9_74979549_74979946 0.24 Fam214a
 family with sequence similarity 214, member A
 3636
 0.24
chr11_4123188_4123541 0.24 Sec14l2
 SEC14-like lipid binding 2
 51
 0.94
chr2_6402913_6403256 0.24 Usp6nl
 USP6 N-terminal like
 17838
 0.18
chr16_13306126_13306394 0.24 Mrtfb
 myocardin related transcription factor B
 41184
 0.16
chr5_25227061_25227222 0.24 E130116L18Rik
 RIKEN cDNA E130116L18 gene
 3988
 0.18
chr7_143052216_143052572 0.24 Cd81
 CD81 antigen
 345
 0.72
chr5_44239117_44239268 0.24 Tapt1
 transmembrane anterior posterior transformation 1
 12566
 0.11
chr10_21448600_21448779 0.24 Gm48386
 predicted gene, 48386
 3053
 0.2
chr14_51064256_51064407 0.24 Rnase12
 ribonuclease, RNase A family, 12 (non-active)
 6670
 0.08
chr8_95432921_95433173 0.24 Cfap20
 cilia and flagella associated protein 20
 1710
 0.27
chr4_106331582_106331733 0.24 Usp24
 ubiquitin specific peptidase 24
 15423
 0.16
chr7_136493461_136493612 0.24 Gm36849
 predicted gene, 36849
 140172
 0.04
chr17_31872001_31872152 0.24 Sik1
 salt inducible kinase 1
 16272
 0.13
chr14_70393462_70393631 0.24 Gm22725
 predicted gene, 22725
 28734
 0.08
chr15_62394159_62394346 0.24 Pvt1
 Pvt1 oncogene
 171649
 0.03
chr3_108770957_108771116 0.23 Aknad1
 AKNA domain containing 1
 10822
 0.15
chr1_194425856_194426037 0.23 Plxna2
 plexin A2
 192272
 0.03
chr14_120498503_120498675 0.23 Rap2a
 RAS related protein 2a
 20145
 0.24
chr11_116108287_116108624 0.23 Trim47
 tripartite motif-containing 47
 336
 0.77
chr4_12237364_12237535 0.23 Gm11847
 predicted gene 11847
 4616
 0.22
chr11_119986483_119986646 0.23 Baiap2
 brain-specific angiogenesis inhibitor 1-associated protein 2
 11107
 0.11
chr16_37588570_37588721 0.23 Gm46559
 predicted gene, 46559
 7545
 0.15
chr7_66083686_66083837 0.23 Selenos
 selenoprotein S
 3800
 0.14
chr8_33867033_33867186 0.23 Rbpms
 RNA binding protein gene with multiple splicing
 13436
 0.16
chr2_103177688_103177876 0.23 Gm13874
 predicted gene 13874
 5
 0.98
chr4_47366562_47366857 0.23 Tgfbr1
 transforming growth factor, beta receptor I
 13099
 0.22
chr7_113778913_113779066 0.23 Spon1
 spondin 1, (f-spondin) extracellular matrix protein
 12815
 0.22
chr6_71837905_71838056 0.23 Gm44771
 predicted gene 44771
 6270
 0.11
chr11_109926883_109927034 0.23 Gm11697
 predicted gene 11697
 9358
 0.22
chr13_36533643_36534408 0.23 Fars2
 phenylalanine-tRNA synthetase 2 (mitochondrial)
 3072
 0.22
chr4_49491887_49492038 0.23 Baat
 bile acid-Coenzyme A: amino acid N-acyltransferase
 11158
 0.12
chr13_117744891_117745098 0.23 4933413L06Rik
 RIKEN cDNA 4933413L06 gene
 24983
 0.26
chr10_69205623_69205774 0.23 Rhobtb1
 Rho-related BTB domain containing 1
 2854
 0.25
chr4_90495794_90495984 0.23 Gm12635
 predicted gene 12635
 43015
 0.17
chr9_118044918_118045069 0.22 Azi2
 5-azacytidine induced gene 2
 4306
 0.22
chr7_127214965_127215278 0.22 Septin1
 septin 1
 4
 0.92
chr6_42251921_42252091 0.22 Gstk1
 glutathione S-transferase kappa 1
 5983
 0.11
chr4_6265892_6266043 0.22 Gm11798
 predicted gene 11798
 5002
 0.21
chr3_10304842_10305071 0.22 A930014E01Rik
 RIKEN cDNA A930014E01 gene
 165
 0.9
chr16_58728459_58728625 0.22 Cldnd1
 claudin domain containing 1
 494
 0.67
chr11_104539702_104539853 0.22 Cdc27
 cell division cycle 27
 10615
 0.11
chr7_142533086_142533550 0.22 Mrpl23
 mitochondrial ribosomal protein L23
 156
 0.91
chr4_99046271_99046475 0.22 Dock7
 dedicator of cytokinesis 7
 8960
 0.18
chr13_34650669_34650865 0.22 Pxdc1
 PX domain containing 1
 1914
 0.22
chr1_88006329_88006480 0.22 Usp40
 ubiquitin specific peptidase 40
 1825
 0.18
chr1_30941324_30941475 0.22 Ptp4a1
 protein tyrosine phosphatase 4a1
 2905
 0.22
chr2_103598963_103599142 0.21 Abtb2
 ankyrin repeat and BTB (POZ) domain containing 2
 32742
 0.16
chr14_21033435_21033611 0.21 Vcl
 vinculin
 11520
 0.18
chr5_45430764_45431089 0.21 Gm42413
 predicted gene, 42413
 3463
 0.17
chr10_40297176_40297522 0.21 Amd1
 S-adenosylmethionine decarboxylase 1
 4227
 0.13
chr2_35103269_35103589 0.21 AI182371
 expressed sequence AI182371
 1886
 0.29
chr3_81997803_81997954 0.21 Asic5
 acid-sensing (proton-gated) ion channel family member 5
 956
 0.53
chr9_57439182_57439333 0.21 Ppcdc
 phosphopantothenoylcysteine decarboxylase
 834
 0.49
chr14_17696257_17696429 0.21 Thrb
 thyroid hormone receptor beta
 35447
 0.21
chr1_74901365_74901516 0.21 Mir375
 microRNA 375
 719
 0.39
chr2_67881464_67881701 0.21 Gm37964
 predicted gene, 37964
 17014
 0.24
chr13_90359772_90359986 0.21 Gm37708
 predicted gene, 37708
 26678
 0.21
chr10_81091333_81091491 0.21 Creb3l3
 cAMP responsive element binding protein 3-like 3
 494
 0.58
chr4_132997648_132997799 0.21 Ahdc1
 AT hook, DNA binding motif, containing 1
 13537
 0.16
chr7_102293168_102293449 0.21 Stim1
 stromal interaction molecule 1
 24981
 0.12
chr5_115018762_115018913 0.21 Sppl3
 signal peptide peptidase 3
 7340
 0.1
chr6_127108825_127109062 0.21 Tigar
 Trp53 induced glycolysis regulatory phosphatase
 607
 0.6
chr4_101282048_101282334 0.21 Gm12801
 predicted gene 12801
 2030
 0.22
chr2_31484723_31485077 0.21 Ass1
 argininosuccinate synthetase 1
 12872
 0.18
chr12_30341867_30342052 0.21 Sntg2
 syntrophin, gamma 2
 15724
 0.25
chr19_32807644_32807795 0.21 Pten
 phosphatase and tensin homolog
 3506
 0.32
chr15_62112429_62112580 0.21 Pvt1
 Pvt1 oncogene
 13475
 0.27
chr6_145793553_145793704 0.21 Rassf8
 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8
 14755
 0.19
chr10_31650590_31650759 0.21 Gm8793
 predicted gene 8793
 11516
 0.21
chr17_83181717_83182272 0.20 Pkdcc
 protein kinase domain containing, cytoplasmic
 33298
 0.17
chr12_34238298_34238489 0.20 Gm18025
 predicted gene, 18025
 52742
 0.18
chr11_73048783_73048934 0.20 Ncbp3
 nuclear cap binding subunit 3
 985
 0.43
chr3_135675431_135675674 0.20 Nfkb1
 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105
 6213
 0.21
chr16_95139892_95140046 0.20 Gm49642
 predicted gene, 49642
 31541
 0.18
chr5_72883801_72883981 0.20 Tec
 tec protein tyrosine kinase
 15408
 0.14
chr2_178680469_178680632 0.20 Cdh26
 cadherin-like 26
 219920
 0.02
chr12_102271886_102272090 0.20 Rin3
 Ras and Rab interactor 3
 11060
 0.21
chr11_78103949_78104116 0.20 Fam222b
 family with sequence similarity 222, member B
 9324
 0.08
chr6_139875525_139875713 0.20 Pik3c2g
 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
 31971
 0.17
chr11_34834139_34834311 0.20 Spdl1
 spindle apparatus coiled-coil protein 1
 584
 0.74
chr17_50544760_50544923 0.20 Plcl2
 phospholipase C-like 2
 35438
 0.22
chr16_33222596_33222759 0.20 Osbpl11
 oxysterol binding protein-like 11
 1921
 0.33
chr15_84412819_84412970 0.19 Shisal1
 shisa like 1
 30803
 0.16
chr1_21262754_21263025 0.19 Gm28836
 predicted gene 28836
 8704
 0.11
chr10_127082531_127082956 0.19 Agap2
 ArfGAP with GTPase domain, ankyrin repeat and PH domain 2
 3836
 0.09
chr2_75722764_75722925 0.19 Gm13656
 predicted gene 13656
 7328
 0.13
chr1_151325474_151325655 0.19 Gm10138
 predicted gene 10138
 18518
 0.13
chr8_44971130_44971287 0.19 Fat1
 FAT atypical cadherin 1
 20994
 0.18
chr10_84885783_84886161 0.19 Ric8b
 RIC8 guanine nucleotide exchange factor B
 31644
 0.17
chr15_80680833_80681008 0.19 Fam83f
 family with sequence similarity 83, member F
 9073
 0.13

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Foxo6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0010046 response to mycotoxin(GO:0010046)
0.1 0.3 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.2 GO:0006741 NADP biosynthetic process(GO:0006741)
0.1 0.2 GO:1904023 regulation of fermentation(GO:0043465) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.1 0.3 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.1 0.2 GO:0071336 regulation of hair follicle cell proliferation(GO:0071336)
0.1 0.2 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.0 0.1 GO:0006481 C-terminal protein methylation(GO:0006481)
0.0 0.1 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.1 GO:1901078 negative regulation of relaxation of muscle(GO:1901078)
0.0 0.1 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0 0.2 GO:0090188 negative regulation of pancreatic juice secretion(GO:0090188)
0.0 0.1 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.0 0.1 GO:0006548 histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0 0.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.1 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.2 GO:0090209 negative regulation of triglyceride metabolic process(GO:0090209)
0.0 0.3 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.0 0.3 GO:0090231 regulation of spindle checkpoint(GO:0090231)
0.0 0.1 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.0 0.1 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.0 0.0 GO:0045917 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.1 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.0 0.2 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.0 0.1 GO:1900042 positive regulation of interleukin-2 secretion(GO:1900042)
0.0 0.1 GO:0042360 vitamin E metabolic process(GO:0042360)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.2 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.0 0.1 GO:0090666 scaRNA localization to Cajal body(GO:0090666)
0.0 0.0 GO:1901421 positive regulation of response to alcohol(GO:1901421)
0.0 0.1 GO:0008355 olfactory learning(GO:0008355)
0.0 0.1 GO:0009106 lipoate metabolic process(GO:0009106)
0.0 0.0 GO:0070640 vitamin D3 metabolic process(GO:0070640)
0.0 0.1 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0 0.1 GO:0090611 ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway(GO:0090611)
0.0 0.1 GO:1904016 response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0 0.1 GO:0015819 lysine transport(GO:0015819)
0.0 0.2 GO:0043651 linoleic acid metabolic process(GO:0043651)
0.0 0.1 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.1 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0 0.1 GO:0002337 B-1a B cell differentiation(GO:0002337)
0.0 0.1 GO:0042985 negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0 0.1 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.0 0.1 GO:0010956 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956)
0.0 0.1 GO:0071265 amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0 0.1 GO:0072396 response to cell cycle checkpoint signaling(GO:0072396) response to DNA integrity checkpoint signaling(GO:0072402) response to DNA damage checkpoint signaling(GO:0072423) response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0 0.1 GO:0000414 regulation of histone H3-K36 methylation(GO:0000414)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.1 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.0 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:1990440 positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress(GO:1990440)
0.0 0.1 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.0 0.1 GO:0010873 positive regulation of cholesterol esterification(GO:0010873)
0.0 0.0 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.0 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
0.0 0.0 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.1 GO:0016557 peroxisome membrane biogenesis(GO:0016557)
0.0 0.1 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
0.0 0.1 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.0 0.1 GO:0006642 triglyceride mobilization(GO:0006642)
0.0 0.1 GO:0009115 xanthine catabolic process(GO:0009115)
0.0 0.1 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.0 0.1 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.0 0.0 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.0 GO:0002155 regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0 0.0 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578)
0.0 0.0 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.0 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0 0.0 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.2 GO:0006999 nuclear pore organization(GO:0006999)
0.0 0.1 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.1 GO:2000188 regulation of cholesterol homeostasis(GO:2000188)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 0.0 GO:0035526 retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0 0.1 GO:0060295 regulation of cilium movement involved in cell motility(GO:0060295) regulation of cilium beat frequency involved in ciliary motility(GO:0060296) regulation of cilium-dependent cell motility(GO:1902019)
0.0 0.0 GO:0060468 prevention of polyspermy(GO:0060468)
0.0 0.0 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0 0.1 GO:1901317 regulation of sperm motility(GO:1901317)
0.0 0.1 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 0.0 GO:0032474 otolith morphogenesis(GO:0032474)
0.0 0.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0 0.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0 0.0 GO:0009235 cobalamin metabolic process(GO:0009235)
0.0 0.0 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.0 0.1 GO:0006555 methionine metabolic process(GO:0006555)
0.0 0.0 GO:0002154 thyroid hormone mediated signaling pathway(GO:0002154)
0.0 0.0 GO:1902965 regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0 0.0 GO:0046271 phenylpropanoid catabolic process(GO:0046271)
0.0 0.0 GO:0051791 medium-chain fatty acid metabolic process(GO:0051791)
0.0 0.0 GO:0035973 aggrephagy(GO:0035973)
0.0 0.0 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0 0.1 GO:0051561 positive regulation of mitochondrial calcium ion concentration(GO:0051561)
0.0 0.0 GO:0051182 coenzyme transport(GO:0051182)
0.0 0.0 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.0 0.0 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.0 0.0 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.0 0.1 GO:0060213 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.0 0.0 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 0.2 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.4 GO:0097431 mitotic spindle pole(GO:0097431)
0.0 0.1 GO:0097413 Lewy body(GO:0097413)
0.0 0.2 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0 0.1 GO:0000322 storage vacuole(GO:0000322)
0.0 0.1 GO:1990246 uniplex complex(GO:1990246)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.1 GO:0034363 intermediate-density lipoprotein particle(GO:0034363)
0.0 0.2 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.0 0.1 GO:0000796 condensin complex(GO:0000796)
0.0 0.1 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.0 0.0 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
0.0 0.0 GO:0033186 CAF-1 complex(GO:0033186)
0.0 0.0 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0 0.0 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.0 0.1 GO:0035749 myelin sheath adaxonal region(GO:0035749)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.1 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0 0.1 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.0 0.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.1 GO:0089701 U2AF(GO:0089701)
0.0 0.1 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.0 0.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.0 0.0 GO:0031094 platelet dense tubular network(GO:0031094)
0.0 0.1 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0090543 Flemming body(GO:0090543)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0071614 linoleic acid epoxygenase activity(GO:0071614)
0.0 0.1 GO:0097016 L27 domain binding(GO:0097016)
0.0 0.1 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 0.2 GO:1990459 transferrin receptor binding(GO:1990459)
0.0 0.1 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.2 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.1 GO:0004083 bisphosphoglycerate 2-phosphatase activity(GO:0004083)
0.0 0.1 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0 0.1 GO:0005047 signal recognition particle binding(GO:0005047)
0.0 0.1 GO:0016743 carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.3 GO:0008432 JUN kinase binding(GO:0008432)
0.0 0.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.1 GO:0070191 methionine-R-sulfoxide reductase activity(GO:0070191)
0.0 0.1 GO:0004667 prostaglandin-D synthase activity(GO:0004667)
0.0 0.1 GO:0001875 lipopolysaccharide receptor activity(GO:0001875)
0.0 0.1 GO:0010997 anaphase-promoting complex binding(GO:0010997)
0.0 0.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.0 0.1 GO:0030620 U2 snRNA binding(GO:0030620)
0.0 0.1 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.1 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.1 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0 0.1 GO:0016623 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.1 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.0 GO:0070653 high-density lipoprotein particle receptor binding(GO:0070653)
0.0 0.1 GO:0015252 hydrogen ion channel activity(GO:0015252)
0.0 0.1 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.0 0.0 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0 0.1 GO:0015181 arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0 0.1 GO:0035473 lipase binding(GO:0035473)
0.0 0.3 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.0 0.1 GO:0032896 palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0 0.1 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.0 GO:0032190 acrosin binding(GO:0032190)
0.0 0.1 GO:0035497 cAMP response element binding(GO:0035497)
0.0 0.1 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0 0.0 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 0.1 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.1 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.0 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.0 GO:0016812 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812)
0.0 0.0 GO:0047023 androsterone dehydrogenase activity(GO:0047023)
0.0 0.2 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 0.1 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.0 0.0 GO:0097109 neuroligin family protein binding(GO:0097109)
0.0 0.1 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0 0.0 GO:0034235 GPI anchor binding(GO:0034235)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.3 GO:0070888 E-box binding(GO:0070888)
0.0 0.0 GO:0031781 melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0 0.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.0 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 0.5 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.0 PID CD40 PATHWAY CD40/CD40L signaling
0.0 0.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.3 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.0 0.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.3 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.1 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.0 0.1 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
0.0 0.2 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.1 REACTOME HORMONE LIGAND BINDING RECEPTORS Genes involved in Hormone ligand-binding receptors
0.0 0.0 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.0 0.1 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 0.0 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation