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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Grhl1

Z-value: 1.75

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Transcription factors associated with Grhl1

Gene Symbol	Gene ID	Gene Info
Grhl1 Ensembl NCBI MGI UniProt	ENSMUSG00000020656.9	grainyhead like transcription factor 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr12_24571852_24572003	Grhl1	356	0.868272	0.84	3.7e-02	Click!
chr12_24600908_24601076	Grhl1	20243	0.147325	0.76	7.9e-02	Click!
chr12_24593470_24593854	Grhl1	12913	0.164995	0.63	1.8e-01	Click!
chr12_24602623_24602807	Grhl1	21966	0.142995	0.59	2.2e-01	Click!
chr12_24599648_24599816	Grhl1	18983	0.150443	-0.58	2.3e-01	Click!

Activity of the Grhl1 motif across conditions

Conditions sorted by the z-value of the Grhl1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_112219735_112219893	1.65	Gm11680	predicted gene 11680	112376	0.07
chr1_39650381_39650532	1.52	D930019O06Rik	RIKEN cDNA D930019O06	280	0.82
chr7_113219987_113220140	1.45	Arntl	aryl hydrocarbon receptor nuclear translocator-like	12506	0.21
chr15_89209095_89209277	1.32	Ppp6r2	protein phosphatase 6, regulatory subunit 2	2367	0.16
chr19_12488282_12488454	1.22	Dtx4	deltex 4, E3 ubiquitin ligase	13086	0.1
chr5_52975314_52975474	1.16	Gm30301	predicted gene, 30301	6643	0.16
chr19_30128513_30128664	1.10	Gldc	glycine decarboxylase	16643	0.18
chr7_30361119_30361389	1.07	Lrfn3	leucine rich repeat and fibronectin type III domain containing 3	1518	0.17
chr6_116119166_116119329	1.06	Tmcc1	transmembrane and coiled coil domains 1	8853	0.16
chr5_9047464_9048021	1.05	Gm40264	predicted gene, 40264	12618	0.15
chr7_68709416_68709593	0.98	Gm44692	predicted gene 44692	16963	0.21
chr5_93250808_93250985	0.97	Ccng2	cyclin G2	16361	0.15
chr2_156447550_156447712	0.96	Gm14225	predicted gene 14225	23	0.96
chr8_106611072_106611260	0.90	Cdh1	cadherin 1	7023	0.18
chr16_22958475_22958991	0.85	Hrg	histidine-rich glycoprotein	7633	0.12
chr4_116176807_116176958	0.85	Gm12951	predicted gene 12951	636	0.51
chr4_60658099_60658456	0.84	Mup11	major urinary protein 11	1461	0.38
chr15_9361830_9361987	0.84	Ugt3a2	UDP glycosyltransferases 3 family, polypeptide A2	26319	0.17
chr8_3252795_3252979	0.84	Gm16180	predicted gene 16180	6817	0.21
chr4_124630137_124630316	0.83	Pou3f1	POU domain, class 3, transcription factor 1	26581	0.11
chr4_61777961_61778274	0.77	Mup19	major urinary protein 19	4107	0.15
chr8_119439834_119440348	0.77	Osgin1	oxidative stress induced growth inhibitor 1	2902	0.2
chr6_5510024_5510175	0.77	Pdk4	pyruvate dehydrogenase kinase, isoenzyme 4	13790	0.27
chr17_56112675_56112850	0.74	Plin4	perilipin 4	2959	0.12
chr15_79741187_79741771	0.70	Sun2	Sad1 and UNC84 domain containing 2	613	0.45
chr10_127591032_127591346	0.67	Gm16217	predicted gene 16217	5359	0.11
chr7_138538849_138539011	0.66	4930543N07Rik	RIKEN cDNA 4930543N07 gene	15300	0.26
chr1_52727224_52727404	0.66	Mfsd6	major facilitator superfamily domain containing 6	44	0.97
chr18_20927286_20927596	0.65	Rnf125	ring finger protein 125	17184	0.19
chr1_165667059_165667210	0.64	Gm18407	predicted gene, 18407	22446	0.1
chrX_42112143_42112724	0.62	Gm14615	predicted gene 14615	18290	0.16
chr15_31062841_31062999	0.62	4930430F21Rik	RIKEN cDNA 4930430F21 gene	23792	0.19
chr11_119058051_119058489	0.61	Cbx8	chromobox 8	17301	0.14
chr2_67976602_67976753	0.61	Gm37964	predicted gene, 37964	78081	0.1
chr2_103801242_103801527	0.60	Caprin1	cell cycle associated protein 1	3735	0.12
chr8_84130948_84131146	0.59	Podnl1	podocan-like 1	3229	0.09
chr11_117176448_117176608	0.59	Sec14l1	SEC14-like lipid binding 1	21459	0.13
chr19_3958627_3958778	0.59	Aldh3b3	aldehyde dehydrogenase 3 family, member B3	57	0.92
chr2_69248790_69248965	0.58	Gm13613	predicted gene 13613	570	0.71
chr10_43235483_43235634	0.58	Pdss2	prenyl (solanesyl) diphosphate synthase, subunit 2	13822	0.17
chr2_126584131_126584290	0.57	Hdc	histidine decarboxylase	14051	0.16
chr11_21235775_21236103	0.57	Vps54	VPS54 GARP complex subunit	3342	0.17
chr11_82858816_82858975	0.56	Rffl	ring finger and FYVE like domain containing protein	11849	0.1
chr19_21038157_21038331	0.56	4930554I06Rik	RIKEN cDNA 4930554I06 gene	66258	0.11
chr2_170287488_170287839	0.56	Gm14270	predicted gene 14270	2628	0.33
chr9_115481085_115481255	0.56	Gm5921	predicted gene 5921	42589	0.13
chr15_9306411_9306595	0.55	Ugt3a1	UDP glycosyltransferases 3 family, polypeptide A1	23002	0.17
chr2_166674892_166675063	0.55	Gm23152	predicted gene, 23152	19835	0.18
chr4_125116849_125117000	0.55	Zc3h12a	zinc finger CCCH type containing 12A	5596	0.15
chr15_94591469_94591640	0.54	Twf1	twinfilin actin binding protein 1	1665	0.39
chr13_45475320_45475484	0.54	Gm23387	predicted gene, 23387	10928	0.21
chr10_93491843_93492023	0.51	Hal	histidine ammonia lyase	3130	0.19
chr16_21332789_21332974	0.51	Magef1	melanoma antigen family F, 1	248	0.93
chr5_128806405_128806573	0.50	Rimbp2	RIMS binding protein 2	13533	0.17
chr14_58032344_58032511	0.50	Gm9012	predicted gene 9012	17396	0.15
chr10_43723444_43723691	0.49	F930017D23Rik	RIKEN cDNA F930017D23 gene	16669	0.12
chr4_57954096_57954315	0.49	Txn1	thioredoxin 1	2206	0.32
chr17_48002012_48002364	0.48	Gm14871	predicted gene 14871	1384	0.35
chr2_93445693_93445960	0.48	Cd82	CD82 antigen	6853	0.17
chr5_9045029_9045180	0.48	Gm40264	predicted gene, 40264	9980	0.15
chr3_19986524_19986675	0.48	Cp	ceruloplasmin	946	0.55
chr13_112071667_112072207	0.47	Gm31104	predicted gene, 31104	66179	0.09
chr19_7310938_7311109	0.47	Gm17227	predicted gene 17227	13289	0.11
chr11_7197846_7198073	0.47	Igfbp1	insulin-like growth factor binding protein 1	177	0.94
chr4_86658429_86658687	0.46	Plin2	perilipin 2	86	0.97
chr10_61427386_61427579	0.45	Nodal	nodal	9510	0.11
chr2_145855907_145856101	0.45	Rin2	Ras and Rab interactor 2	6640	0.18
chr8_12800767_12800949	0.45	Atp11a	ATPase, class VI, type 11A	10558	0.16
chr13_46630953_46631134	0.45	Cap2	CAP, adenylate cyclase-associated protein, 2 (yeast)	9015	0.17
chr7_118534971_118535395	0.44	Coq7	demethyl-Q 7	1827	0.29
chr7_65692899_65693066	0.43	Tm2d3	TM2 domain containing 3	426	0.84
chr11_22814100_22814280	0.42	Gm20456	predicted gene 20456	25109	0.1
chr3_82291765_82291930	0.42	Map9	microtubule-associated protein 9	66197	0.13
chr10_81088340_81088663	0.42	Creb3l3	cAMP responsive element binding protein 3-like 3	3405	0.1
chr14_29996020_29996356	0.42	Il17rb	interleukin 17 receptor B	2271	0.17
chr17_13714881_13715054	0.42	Tcte2	t-complex-associated testis expressed 2	17931	0.13
chr16_24085290_24085914	0.42	Gm46545	predicted gene, 46545	2912	0.23
chr11_101729161_101729323	0.42	Dhx8	DEAH (Asp-Glu-Ala-His) box polypeptide 8	3677	0.17
chr5_122131253_122131408	0.41	Ccdc63	coiled-coil domain containing 63	673	0.61
chr4_60066252_60066431	0.41	Mup7	major urinary protein 7	4070	0.21
chr2_69418752_69418922	0.41	Dhrs9	dehydrogenase/reductase (SDR family) member 9	38392	0.15
chr4_61435652_61435957	0.40	Mup15	major urinary protein 15	3939	0.23
chr1_182495453_182495613	0.40	Gm37069	predicted gene, 37069	1377	0.32
chr16_35742175_35742539	0.40	Gm25967	predicted gene, 25967	20124	0.13
chr14_120534643_120535027	0.40	Rap2a	RAS related protein 2a	56391	0.14
chr14_69728721_69728885	0.40	Chmp7	charged multivesicular body protein 7	2072	0.22
chr2_69340135_69340332	0.39	Abcb11	ATP-binding cassette, sub-family B (MDR/TAP), member 11	2367	0.28
chr2_32252717_32252887	0.39	Pomt1	protein-O-mannosyltransferase 1	1529	0.19
chr19_4326385_4326550	0.39	Kdm2a	lysine (K)-specific demethylase 2A	1602	0.23
chr4_61948678_61948918	0.39	Mup-ps19	major urinary protein, pseudogene 19	11113	0.17
chr11_97126973_97127136	0.39	Gm11572	predicted gene 11572	10139	0.09
chr10_67792831_67793043	0.39	Gm29774	predicted gene, 29774	265	0.9
chr11_67516215_67516384	0.39	Gas7	growth arrest specific 7	30855	0.19
chr11_119191869_119192119	0.38	Gm11753	predicted gene 11753	7478	0.13
chr18_60848442_60848618	0.38	Tcof1	treacle ribosome biogenesis factor 1	84	0.96
chr13_20007652_20007822	0.38	Gm5446	predicted gene 5446	11933	0.27
chr9_44268479_44268675	0.38	Nlrx1	NLR family member X1	22	0.93
chr10_63160777_63160928	0.38	Mypn	myopalladin	38168	0.1
chr15_67434225_67434396	0.37	1700012I11Rik	RIKEN cDNA 1700012I11 gene	207541	0.02
chr11_48819928_48820131	0.37	Trim41	tripartite motif-containing 41	2676	0.13
chr15_62017519_62017928	0.37	Pvt1	Pvt1 oncogene	20263	0.19
chr8_40896761_40897111	0.37	Slc7a2	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	1502	0.36
chr11_75653315_75653490	0.36	Myo1c	myosin IC	1326	0.31
chr7_44496721_44496957	0.36	Fam71e1	family with sequence similarity 71, member E1	145	0.66
chr12_80107353_80107544	0.35	Zfp36l1	zinc finger protein 36, C3H type-like 1	5546	0.13
chr3_58683500_58683862	0.35	Siah2	siah E3 ubiquitin protein ligase 2	2356	0.2
chr10_8066302_8066722	0.35	Gm48614	predicted gene, 48614	45220	0.16
chr19_44985600_44985928	0.35	4930414N06Rik	RIKEN cDNA 4930414N06 gene	1214	0.29
chr13_41249141_41249488	0.35	Smim13	small integral membrane protein 13	530	0.68
chr17_35667833_35668010	0.35	Vars2	valyl-tRNA synthetase 2, mitochondrial	329	0.65
chr11_34072364_34072537	0.35	Lcp2	lymphocyte cytosolic protein 2	5727	0.22
chr4_62049824_62050253	0.35	Mup20	major urinary protein 20	4120	0.16
chr17_29049918_29050142	0.35	Gm41556	predicted gene, 41556	3306	0.11
chr19_3609825_3610173	0.35	Lrp5	low density lipoprotein receptor-related protein 5	5793	0.17
chr19_24225293_24225657	0.35	Tjp2	tight junction protein 2	445	0.83
chr17_48324406_48324576	0.35	B430306N03Rik	RIKEN cDNA B430306N03 gene	8067	0.12
chr16_32008396_32008555	0.34	Senp5	SUMO/sentrin specific peptidase 5	5188	0.1
chr1_160982820_160983305	0.34	Serpinc1	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	1706	0.15
chr12_100477440_100477617	0.34	Ttc7b	tetratricopeptide repeat domain 7B	11230	0.16
chr18_65037226_65037468	0.34	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	11545	0.22
chr4_86656497_86656682	0.34	Plin2	perilipin 2	2055	0.29
chr6_136469183_136469418	0.33	Gm6728	predicted gene 6728	17886	0.12
chr17_24236940_24237256	0.33	Mir5134	microRNA 5134	2494	0.12
chr14_73135659_73135810	0.33	Rcbtb2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	3034	0.27
chr9_43151950_43152122	0.33	Pou2f3	POU domain, class 2, transcription factor 3	8832	0.18
chr11_96860496_96860647	0.33	Copz2	coatomer protein complex, subunit zeta 2	6440	0.09
chr13_34154759_34154927	0.32	Psmg4	proteasome (prosome, macropain) assembly chaperone 4	8121	0.12
chr8_126588770_126588952	0.32	Irf2bp2	interferon regulatory factor 2 binding protein 2	5125	0.24
chr10_99384294_99384806	0.32	B530045E10Rik	RIKEN cDNA B530045E10 gene	18240	0.17
chr10_75741017_75741184	0.32	Cabin1	calcineurin binding protein 1	7329	0.12
chr7_140899673_140899825	0.32	Cox8b	cytochrome c oxidase subunit 8B	697	0.38
chr5_89018649_89018800	0.32	Slc4a4	solute carrier family 4 (anion exchanger), member 4	9242	0.29
chr1_88211821_88211976	0.32	Ugt1a1	UDP glucuronosyltransferase 1 family, polypeptide A1	61	0.93
chr2_32453958_32454145	0.32	Slc25a25	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 25	2606	0.15
chr19_47402965_47403381	0.32	Sh3pxd2a	SH3 and PX domains 2A	7186	0.23
chr4_60497810_60497972	0.31	Mup1	major urinary protein 1	1441	0.3
chr4_126097782_126097933	0.31	Lsm10	U7 snRNP-specific Sm-like protein LSM10	1197	0.32
chr7_14536045_14536258	0.31	Obox4-ps2	oocyte specific homeobox 4, pseudogene 2	6085	0.12
chr2_52298963_52299373	0.31	Gm22095	predicted gene, 22095	16091	0.19
chr4_60737134_60737406	0.31	Mup12	major urinary protein 12	4056	0.21
chr19_55744520_55744671	0.31	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	1750	0.5
chr2_38378853_38379004	0.31	Gm13584	predicted gene 13584	14948	0.14
chr9_110361719_110362313	0.31	Scap	SREBF chaperone	399	0.76
chr3_30593178_30593362	0.31	1600017P15Rik	RIKEN cDNA 1600017P15 gene	2463	0.17
chr1_36466108_36466267	0.30	Cnnm4	cyclin M4	5433	0.11
chr8_126595451_126595638	0.30	Irf2bp2	interferon regulatory factor 2 binding protein 2	1558	0.45
chr6_108163692_108163904	0.30	Sumf1	sulfatase modifying factor 1	11512	0.21
chr11_119976291_119976457	0.30	Baiap2	brain-specific angiogenesis inhibitor 1-associated protein 2	16353	0.1
chr8_69920774_69920972	0.29	Gatad2a	GATA zinc finger domain containing 2A	15653	0.1
chr10_13965620_13965780	0.29	Hivep2	human immunodeficiency virus type I enhancer binding protein 2	375	0.87
chr15_61942121_61942278	0.29	Gm37947	predicted gene, 37947	41103	0.16
chr3_138527126_138527297	0.29	Eif4e	eukaryotic translation initiation factor 4E	74	0.92
chr5_66214590_66214851	0.29	Gm3822	predicted gene 3822	27	0.96
chr1_192094576_192094741	0.28	Traf5	TNF receptor-associated factor 5	2099	0.2
chr5_140797604_140797806	0.28	Gna12	guanine nucleotide binding protein, alpha 12	32452	0.15
chr16_24489944_24490119	0.28	Morf4l1-ps1	mortality factor 4 like 1, pseudogene 1	39363	0.15
chr5_64805521_64805672	0.28	Gm20033	predicted gene, 20033	1479	0.26
chr13_93814179_93814589	0.28	Mir5624	microRNA 5624	23607	0.15
chr18_69355911_69356077	0.28	Tcf4	transcription factor 4	7050	0.28
chr2_103454731_103454882	0.28	Elf5	E74-like factor 5	6068	0.19
chr5_88918674_88918881	0.28	Slc4a4	solute carrier family 4 (anion exchanger), member 4	15755	0.23
chr2_167118045_167118226	0.28	Kcnb1	potassium voltage gated channel, Shab-related subfamily, member 1	16309	0.1
chr9_116101907_116102117	0.27	Gm9385	predicted pseudogene 9385	60948	0.11
chr12_54738742_54738899	0.27	Gm22317	predicted gene, 22317	198	0.84
chr12_57231180_57231526	0.27	Mipol1	mirror-image polydactyly 1	862	0.42
chr2_30967908_30968194	0.27	Tor1a	torsin family 1, member A (torsin A)	118	0.94
chr4_133756501_133756653	0.27	Arid1a	AT rich interactive domain 1A (SWI-like)	192	0.93
chr10_128303547_128303722	0.27	Pan2	PAN2 poly(A) specific ribonuclease subunit	236	0.8
chr16_37503864_37504075	0.26	Gtf2e1	general transcription factor II E, polypeptide 1 (alpha subunit)	35807	0.13
chr11_103113058_103113588	0.26	Hexim1	hexamethylene bis-acetamide inducible 1	2908	0.16
chr2_103760559_103761137	0.26	Nat10	N-acetyltransferase 10	78	0.96
chr6_48395304_48395463	0.26	Gm44696	predicted gene 44696	25	0.71
chr4_61223975_61224206	0.26	Mup13	major urinary protein 13	4181	0.23
chr4_53120634_53120947	0.26	Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	39105	0.15
chr17_8652292_8652725	0.26	Gm15425	predicted gene 15425	83648	0.08
chr17_36836564_36836799	0.26	Trim26	tripartite motif-containing 26	453	0.65
chr13_52828377_52828538	0.26	BB123696	expressed sequence BB123696	71252	0.11
chr19_61048615_61048813	0.26	Gm22520	predicted gene, 22520	35169	0.14
chr11_4123188_4123541	0.25	Sec14l2	SEC14-like lipid binding 2	51	0.94
chr4_105196590_105196741	0.25	Plpp3	phospholipid phosphatase 3	39318	0.2
chr11_115619159_115619461	0.25	Slc25a19	solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19	1405	0.23
chr8_84989857_84990140	0.25	Hook2	hook microtubule tethering protein 2	605	0.43
chr11_75439481_75439671	0.25	Serpinf2	serine (or cysteine) peptidase inhibitor, clade F, member 2	2	0.94
chr4_134796652_134796803	0.24	Maco1	macoilin 1	14486	0.18
chr4_118410618_118411038	0.24	Med8	mediator complex subunit 8	480	0.64
chr10_72310190_72310549	0.24	Gm9923	predicted pseudogene 9923	1048	0.69
chr3_58334130_58334299	0.24	Gm43730	predicted gene 43730	18904	0.18
chr2_180118773_180118959	0.24	Osbpl2	oxysterol binding protein-like 2	440	0.73
chr17_88597845_88598024	0.24	Ston1	stonin 1	238	0.91
chr2_50813860_50814047	0.24	Gm13498	predicted gene 13498	95731	0.08
chr5_30231710_30232189	0.24	Selenoi	selenoprotein I	632	0.63
chr11_115831081_115831263	0.24	Llgl2	LLGL2 scribble cell polarity complex component	796	0.45
chr7_109526487_109526662	0.24	Gm24888	predicted gene, 24888	5294	0.12
chr3_98296908_98297093	0.24	Gm43189	predicted gene 43189	10012	0.15
chr5_136170628_136170833	0.24	Orai2	ORAI calcium release-activated calcium modulator 2	17	0.96
chr3_87009765_87009927	0.24	Cd1d1	CD1d1 antigen	10405	0.13
chr16_23081291_23081442	0.23	Gm8134	predicted gene 8134	11577	0.06
chr6_86609579_86609730	0.23	Gm44369	predicted gene, 44369	18224	0.1
chr10_8657884_8658275	0.23	Gm24374	predicted gene, 24374	15145	0.23
chr18_13671248_13671407	0.23	AC103362.1	novel transcript	69927	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Grhl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0060137	maternal process involved in parturition(GO:0060137)
0.1	0.3	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.1	0.4	GO:1900242	regulation of synaptic vesicle endocytosis(GO:1900242)
0.1	0.3	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.1	0.2	GO:0018879	biphenyl metabolic process(GO:0018879)
0.1	0.2	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.1	0.3	GO:1903011	negative regulation of bone development(GO:1903011)
0.1	0.2	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1	0.3	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.1	0.2	GO:0045472	response to ether(GO:0045472)
0.1	0.2	GO:0060066	oviduct development(GO:0060066)
0.1	0.2	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
0.1	0.2	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	0.2	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.3	GO:0051918	negative regulation of fibrinolysis(GO:0051918)
0.0	0.1	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.0	0.1	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.2	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.1	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.2	GO:0006548	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:1903660	regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0	0.2	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.2	GO:0019087	transformation of host cell by virus(GO:0019087)
0.0	0.1	GO:0044533	induction of programmed cell death(GO:0012502) positive regulation of apoptotic process in other organism(GO:0044533) positive regulation by symbiont of host programmed cell death(GO:0052042) positive regulation by symbiont of host apoptotic process(GO:0052151) positive regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052330) positive regulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052501) positive regulation of apoptotic process by virus(GO:0060139)
0.0	0.1	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.1	GO:1902837	amino acid import into cell(GO:1902837)
0.0	0.4	GO:0042790	transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0	0.2	GO:0046618	drug export(GO:0046618)
0.0	0.3	GO:0032211	negative regulation of telomere maintenance via telomerase(GO:0032211)
0.0	0.2	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.2	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.1	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.5	GO:0006825	copper ion transport(GO:0006825)
0.0	0.1	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.1	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	0.1	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.1	GO:1901727	positive regulation of histone deacetylase activity(GO:1901727)
0.0	0.2	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.1	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.0	0.2	GO:0046826	negative regulation of protein export from nucleus(GO:0046826)
0.0	0.2	GO:0071501	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0008355	olfactory learning(GO:0008355)
0.0	0.0	GO:0002752	cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.0	0.1	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.1	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.5	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.0	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.0	0.1	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.1	GO:0002447	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.0	0.1	GO:0006627	protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0	0.0	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0	0.1	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0	0.2	GO:0090308	regulation of methylation-dependent chromatin silencing(GO:0090308)
0.0	0.1	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.0	0.0	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.1	GO:0071442	positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0	0.1	GO:0044154	histone H3-K14 acetylation(GO:0044154)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.8	GO:0015909	long-chain fatty acid transport(GO:0015909)
0.0	0.1	GO:2000667	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.1	GO:0006123	mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0	0.1	GO:0006057	cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.1	GO:0015766	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.0	GO:0014858	positive regulation of skeletal muscle cell proliferation(GO:0014858)
0.0	0.1	GO:1903977	positive regulation of glial cell migration(GO:1903977)
0.0	0.2	GO:0009396	folic acid-containing compound biosynthetic process(GO:0009396)
0.0	0.2	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.0	GO:2000065	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	0.0	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.2	GO:0002115	store-operated calcium entry(GO:0002115)
0.0	0.0	GO:2000586	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.1	GO:0072095	regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.0	0.0	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.0	0.0	GO:1903298	regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0	0.1	GO:0001867	complement activation, lectin pathway(GO:0001867)
0.0	0.0	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0	0.1	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.0	GO:0006663	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.1	GO:0044791	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.1	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.1	GO:1901628	positive regulation of postsynaptic membrane organization(GO:1901628)
0.0	0.1	GO:0035745	T-helper 2 cell cytokine production(GO:0035745)
0.0	0.0	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0	0.0	GO:0060399	positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0	0.3	GO:0071549	cellular response to dexamethasone stimulus(GO:0071549)
0.0	0.1	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.0	GO:0006189	'de novo' IMP biosynthetic process(GO:0006189)
0.0	0.1	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.0	GO:0042998	positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0	0.0	GO:1903596	regulation of gap junction assembly(GO:1903596) positive regulation of gap junction assembly(GO:1903598)
0.0	0.1	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	0.0	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.1	GO:0045404	positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.1	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.0	0.1	GO:2001184	positive regulation of interleukin-12 secretion(GO:2001184)
0.0	0.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.0	GO:0009174	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.0	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.0	0.0	GO:0070268	cornification(GO:0070268)
0.0	0.1	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.0	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.0	GO:0014745	negative regulation of muscle adaptation(GO:0014745)
0.0	0.0	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.0	0.1	GO:0032484	Ral protein signal transduction(GO:0032484)
0.0	0.1	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.0	0.0	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.0	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0	0.0	GO:1901668	regulation of superoxide dismutase activity(GO:1901668)
0.0	0.0	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.1	GO:0090160	Golgi to lysosome transport(GO:0090160)
0.0	0.0	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.1	GO:1902715	positive regulation of interferon-gamma secretion(GO:1902715)
0.0	0.0	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.2	GO:0032878	regulation of establishment or maintenance of cell polarity(GO:0032878)
0.0	0.0	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
0.0	0.0	GO:0060671	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0	0.0	GO:0046098	guanine metabolic process(GO:0046098)
0.0	0.1	GO:2001185	regulation of CD8-positive, alpha-beta T cell activation(GO:2001185)
0.0	0.1	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0	0.1	GO:0043922	negative regulation by host of viral transcription(GO:0043922)
0.0	0.0	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.2	GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.0	0.2	GO:0009813	flavonoid biosynthetic process(GO:0009813) flavonoid glucuronidation(GO:0052696)
0.0	0.1	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469) determination of liver left/right asymmetry(GO:0071910)
0.0	0.0	GO:0003415	chondrocyte hypertrophy(GO:0003415)
0.0	0.2	GO:0046854	phosphatidylinositol phosphorylation(GO:0046854)
0.0	0.0	GO:0097283	keratinocyte apoptotic process(GO:0097283) regulation of keratinocyte apoptotic process(GO:1902172)
0.0	0.0	GO:0060283	negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.0	0.1	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0	0.1	GO:0090267	positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267)
0.0	0.0	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.0	GO:0035425	autocrine signaling(GO:0035425)
0.0	0.1	GO:0006744	ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0031998	regulation of fatty acid beta-oxidation(GO:0031998)
0.0	0.1	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1	0.2	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.1	0.2	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.1	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.1	GO:0032010	phagolysosome(GO:0032010)
0.0	0.6	GO:0033391	chromatoid body(GO:0033391)
0.0	0.3	GO:0034992	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0	0.1	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0070695	FHF complex(GO:0070695)
0.0	0.1	GO:0097255	R2TP complex(GO:0097255)
0.0	0.1	GO:0044613	nuclear pore central transport channel(GO:0044613)
0.0	0.3	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.1	GO:0031502	dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:0000938	GARP complex(GO:0000938)
0.0	0.1	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.2	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.1	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0033503	HULC complex(GO:0033503)
0.0	0.3	GO:0071564	npBAF complex(GO:0071564)
0.0	0.2	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.0	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.1	GO:0016600	flotillin complex(GO:0016600)
0.0	0.1	GO:0005751	mitochondrial respiratory chain complex IV(GO:0005751)
0.0	0.0	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:1990246	uniplex complex(GO:1990246)
0.0	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.2	GO:0072546	ER membrane protein complex(GO:0072546)
0.0	0.0	GO:0097427	microtubule bundle(GO:0097427)
0.0	0.9	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0061574	ASAP complex(GO:0061574)
0.0	0.0	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.2	GO:0005697	telomerase holoenzyme complex(GO:0005697)
0.0	0.0	GO:0020018	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0	0.1	GO:0000124	SAGA complex(GO:0000124)
0.0	0.0	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.2	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.1	GO:0002116	semaphorin receptor complex(GO:0002116)
0.0	0.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.1	GO:0000235	astral microtubule(GO:0000235)
0.0	0.0	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.0	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.0	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.0	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.0	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.1	0.2	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.1	0.6	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	0.6	GO:0004028	3-chloroallyl aldehyde dehydrogenase activity(GO:0004028)
0.1	0.2	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.3	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.1	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.3	GO:0019113	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.2	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.2	GO:0035005	1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.5	GO:0005521	lamin binding(GO:0005521)
0.0	0.2	GO:0035473	lipase binding(GO:0035473)
0.0	0.1	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.0	0.1	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0051870	methotrexate binding(GO:0051870)
0.0	0.1	GO:0015181	arginine transmembrane transporter activity(GO:0015181) L-lysine transmembrane transporter activity(GO:0015189)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0042015	interleukin-20 binding(GO:0042015)
0.0	0.1	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.3	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.1	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.0	0.1	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.1	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.1	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.1	GO:0004096	catalase activity(GO:0004096)
0.0	0.2	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.1	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.2	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.1	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0	0.1	GO:0070698	type I activin receptor binding(GO:0070698)
0.0	0.1	GO:0008506	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0098632	protein binding involved in cell-cell adhesion(GO:0098632)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.2	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.2	GO:0015279	store-operated calcium channel activity(GO:0015279)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.0	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0004169	dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0	0.0	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.2	GO:0016594	glycine binding(GO:0016594)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.2	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.0	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.2	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.0	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.0	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.0	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.2	GO:0005186	pheromone activity(GO:0005186)
0.0	0.1	GO:0017154	semaphorin receptor activity(GO:0017154)
0.0	0.0	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.0	0.3	GO:0070888	E-box binding(GO:0070888)
0.0	0.0	GO:0015467	G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0	0.1	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.0	GO:0036374	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	0.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	0.0	GO:0034584	piRNA binding(GO:0034584)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.0	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
1.1	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.0	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.6	PID AP1 PATHWAY	AP-1 transcription factor network
0.3	ST P38 MAPK PATHWAY	p38 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.5	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.6	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.2	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.2	REACTOME MTORC1 MEDIATED SIGNALLING	Genes involved in mTORC1-mediated signalling
0.5	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.3	REACTOME MITOCHONDRIAL TRNA AMINOACYLATION	Genes involved in Mitochondrial tRNA aminoacylation
1.1	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.4	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.3	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.2	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway

Results for Grhl1

Z-value: 1.75

Motif logo

Transcription factors associated with Grhl1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Grhl1 motif across conditions

Conditions sorted by the z-value of the Grhl1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Grhl1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: