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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Hes5_Hes7

Z-value: 2.64

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Transcription factors associated with Hes5_Hes7

Gene Symbol	Gene ID	Gene Info
Hes5 Ensembl NCBI MGI UniProt	ENSMUSG00000048001.7	hes family bHLH transcription factor 5
Hes7 Ensembl NCBI MGI UniProt	ENSMUSG00000023781.2	hes family bHLH transcription factor 7

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr4_154946325_154946641	Hes5	14440	0.105527	0.47	3.5e-01	Click!
chr4_154946732_154946894	Hes5	14110	0.105940	0.45	3.8e-01	Click!
chr11_69114771_69114928	Hes7	5555	0.080045	0.91	1.2e-02	Click!
chr11_69110217_69110963	Hes7	9814	0.070555	0.70	1.2e-01	Click!
chr11_69115062_69115266	Hes7	5240	0.081385	-0.64	1.7e-01	Click!
chr11_69111108_69111280	Hes7	9210	0.071467	-0.53	2.8e-01	Click!
chr11_69118830_69118983	Hes7	1498	0.185923	-0.52	2.9e-01	Click!

Activity of the Hes5_Hes7 motif across conditions

Conditions sorted by the z-value of the Hes5_Hes7 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr17_47329074_47329231	5.83	Trerf1	transcriptional regulating factor 1	35083	0.1
chr6_116653898_116654072	4.13	Depp1	DEPP1 autophagy regulator	3289	0.14
chr12_85748786_85748937	3.43	Flvcr2	feline leukemia virus subgroup C cellular receptor 2	2322	0.22
chr4_124005727_124005878	3.19	Gm12902	predicted gene 12902	79568	0.07
chr16_17802864_17803015	3.10	Scarf2	scavenger receptor class F, member 2	463	0.67
chr3_90473370_90473521	2.90	Gm43595	predicted gene 43595	2486	0.12
chr5_113204337_113204488	2.89	2900026A02Rik	RIKEN cDNA 2900026A02 gene	16824	0.12
chr11_55126402_55126555	2.73	Mup-ps22	major urinary protein, pseudogene 22	2783	0.16
chr1_40217644_40217810	2.72	Il1r1	interleukin 1 receptor, type I	7353	0.21
chr12_82743501_82743658	2.62	Gm22149	predicted gene, 22149	28877	0.22
chr16_93793312_93793530	2.28	Dop1b	DOP1 leucine zipper like protein B	632	0.59
chr7_64186009_64186191	2.13	Trpm1	transient receptor potential cation channel, subfamily M, member 1	499	0.73
chr13_73720273_73720547	1.98	Slc12a7	solute carrier family 12, member 7	12684	0.14
chr12_110688126_110688290	1.89	Hsp90aa1	heat shock protein 90, alpha (cytosolic), class A member 1	4972	0.13
chr16_23293902_23294209	1.79	St6gal1	beta galactoside alpha 2,6 sialyltransferase 1	3585	0.22
chr11_95223583_95223772	1.76	Gm11515	predicted gene 11515	1955	0.26
chr7_110969269_110969430	1.75	Mrvi1	MRV integration site 1	12709	0.18
chr10_19443595_19443775	1.74	Gm33104	predicted gene, 33104	43030	0.15
chr14_63479379_63479556	1.73	Gm47074	predicted gene, 47074	4091	0.16
chr8_69822995_69823178	1.69	Lpar2	lysophosphatidic acid receptor 2	502	0.65
chr13_59767243_59767411	1.69	Isca1	iron-sulfur cluster assembly 1	2150	0.13
chr4_45487423_45487587	1.67	Shb	src homology 2 domain-containing transforming protein B	1898	0.29
chr9_58112850_58113072	1.66	Ccdc33	coiled-coil domain containing 33	1399	0.31
chr11_115249882_115250043	1.59	Gm25837	predicted gene, 25837	3316	0.14
chr10_85829073_85829241	1.56	Pwp1	PWP1 homolog, endonuclein	337	0.6
chr1_74121947_74122123	1.56	Tns1	tensin 1	2412	0.22
chr12_98919687_98919838	1.51	Ttc8	tetratricopeptide repeat domain 8	812	0.61
chr11_118265609_118265912	1.45	Usp36	ubiquitin specific peptidase 36	288	0.89
chr6_54760026_54760215	1.42	Znrf2	zinc and ring finger 2	56796	0.1
chr2_119322511_119322662	1.40	Gm14207	predicted gene 14207	2957	0.15
chr11_88849470_88849637	1.37	Akap1	A kinase (PRKA) anchor protein 1	1950	0.25
chr8_119901427_119901603	1.33	Usp10	ubiquitin specific peptidase 10	8845	0.16
chr6_112939448_112939605	1.32	Srgap3	SLIT-ROBO Rho GTPase activating protein 3	7228	0.15
chr1_157594710_157594868	1.31	Gm37682	predicted gene, 37682	1517	0.33
chr17_56780692_56780856	1.31	Rfx2	regulatory factor X, 2 (influences HLA class II expression)	2930	0.15
chrX_12103317_12103582	1.29	Bcor	BCL6 interacting corepressor	22896	0.23
chr13_113032070_113032240	1.28	Cdc20b	cell division cycle 20B	2956	0.12
chr2_172580659_172580839	1.27	Tfap2c	transcription factor AP-2, gamma	28633	0.18
chr11_75213340_75213711	1.27	Rtn4rl1	reticulon 4 receptor-like 1	19742	0.1
chr9_59664998_59665149	1.23	Pkm	pyruvate kinase, muscle	271	0.87
chr6_56708894_56709045	1.20	Lsm5	LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated	4259	0.2
chr5_51391034_51391201	1.19	Gm42614	predicted gene 42614	93188	0.07
chr2_146247712_146247863	1.19	A930019D19Rik	RIKEN cDNA A930019D19 gene	11499	0.16
chr16_97912494_97912647	1.17	C2cd2	C2 calcium-dependent domain containing 2	10036	0.18
chr6_141943721_141944090	1.14	Slco1a1	solute carrier organic anion transporter family, member 1a1	2905	0.31
chr19_44881162_44881335	1.12	Gm5246	predicted gene 5246	30239	0.11
chr11_100830367_100830521	1.11	Stat5b	signal transducer and activator of transcription 5B	7916	0.13
chr5_103976460_103976626	1.10	Hsd17b13	hydroxysteroid (17-beta) dehydrogenase 13	783	0.55
chr13_51918889_51919046	1.09	Gm26651	predicted gene, 26651	54247	0.13
chr1_180757970_180758155	1.07	Gm37768	predicted gene, 37768	2226	0.19
chr8_88361045_88361206	1.07	Brd7	bromodomain containing 7	889	0.61
chr16_31404159_31404311	1.06	Gm49736	predicted gene, 49736	8232	0.12
chr1_22645397_22645563	1.06	Gm26866	predicted gene, 26866	95284	0.09
chr17_56408931_56409082	1.04	Ptprs	protein tyrosine phosphatase, receptor type, S	5424	0.15
chr7_127922875_127923045	1.03	Kat8	K(lysine) acetyltransferase 8	3172	0.09
chr10_115586794_115587149	1.03	Lgr5	leucine rich repeat containing G protein coupled receptor 5	522	0.79
chr9_107655076_107655227	1.01	Slc38a3	solute carrier family 38, member 3	869	0.34
chr7_142081836_142082027	1.00	Gm25416	predicted gene, 25416	3494	0.11
chr2_172511032_172511203	1.00	Gm14303	predicted gene 14303	1426	0.37
chr13_43212570_43212901	1.00	Tbc1d7	TBC1 domain family, member 7	41234	0.15
chr7_127930738_127930911	0.98	Prss8	protease, serine 8 (prostasin)	720	0.39
chr6_86129871_86130022	0.98	Gm19596	predicted gene, 19596	17206	0.14
chr14_13356089_13356268	0.97	Gm15913	predicted gene 15913	2098	0.41
chr18_38992299_38992593	0.96	Arhgap26	Rho GTPase activating protein 26	699	0.63
chr11_107043437_107043599	0.95	Bptf	bromodomain PHD finger transcription factor	188	0.93
chr1_74396566_74396720	0.94	Mir26b	microRNA 26b	2333	0.16
chr1_168459622_168459790	0.94	Pbx1	pre B cell leukemia homeobox 1	27436	0.2
chr4_148074902_148075079	0.91	Gm13201	predicted gene 13201	430	0.69
chr4_72270584_72270739	0.91	C630043F03Rik	RIKEN cDNA C630043F03 gene	69313	0.11
chr6_84583452_84583643	0.91	Cyp26b1	cytochrome P450, family 26, subfamily b, polypeptide 1	4133	0.29
chr11_55117495_55117662	0.89	Atp5pb-ps	ATP synthase peripheral stalk-membrane subunit b, pseudogene	1217	0.33
chr11_97958258_97958415	0.89	Gm11633	predicted gene 11633	10456	0.1
chr10_21046859_21047052	0.87	Gm20149	predicted gene, 20149	1944	0.28
chr5_76063442_76063602	0.87	Gm6051	predicted gene 6051	2759	0.24
chr2_168003546_168003752	0.86	Gm14236	predicted gene 14236	6880	0.16
chr4_126602196_126602347	0.85	5730409E04Rik	RIKEN cDNA 5730409E04Rik gene	7547	0.12
chr3_104523724_104523899	0.85	Lrig2	leucine-rich repeats and immunoglobulin-like domains 2	11893	0.13
chr17_25274284_25274449	0.84	Ube2i	ubiquitin-conjugating enzyme E2I	56	0.93
chr14_61125286_61125469	0.83	Sacs	sacsin	13080	0.21
chr10_17653872_17654032	0.82	Gm47771	predicted gene, 47771	4561	0.27
chr17_5926825_5927009	0.82	Gm8376	predicted gene 8376	12170	0.17
chr5_103776042_103776193	0.80	Aff1	AF4/FMR2 family, member 1	8242	0.22
chr16_4415377_4415550	0.80	Adcy9	adenylate cyclase 9	4124	0.25
chr6_32528153_32528323	0.80	Plxna4os1	plexin A4, opposite strand 1	17165	0.22
chr3_85829172_85829346	0.79	Fam160a1	family with sequence similarity 160, member A1	11968	0.16
chr4_37093076_37093227	0.79	Taf9-ps	TATA-box binding protein associated factor 9, pseudogene	46723	0.17
chr5_139359350_139359501	0.77	Cyp2w1	cytochrome P450, family 2, subfamily w, polypeptide 1	4849	0.12
chr11_59809129_59809311	0.77	Flcn	folliculin	368	0.65
chr10_86685214_86685383	0.77	1810014B01Rik	RIKEN cDNA 1810014B01 gene	227	0.82
chr18_38177426_38177598	0.77	Pcdh1	protocadherin 1	25651	0.12
chr8_123046808_123046972	0.76	2810013P06Rik	RIKEN cDNA 2810013P06 gene	4424	0.12
chr7_25220574_25220762	0.76	Dedd2	death effector domain-containing DNA binding protein 2	53	0.89
chr3_94654096_94654253	0.76	Tuft1	tuftelin 1	4626	0.11
chr19_3840572_3840723	0.75	Chka	choline kinase alpha	11126	0.09
chr12_82856018_82856227	0.75	1700085C21Rik	RIKEN cDNA 1700085C21 gene	83033	0.09
chr7_80636985_80637158	0.74	Gm15880	predicted gene 15880	1054	0.48
chr3_85777976_85778136	0.73	Fam160a1	family with sequence similarity 160, member A1	31790	0.16
chr14_45983632_45983829	0.73	Gm49192	predicted gene, 49192	7307	0.19
chr9_65289050_65289226	0.72	Clpx	caseinolytic mitochondrial matrix peptidase chaperone subunit	5122	0.12
chr13_69002748_69002930	0.70	Gm35161	predicted gene, 35161	2417	0.22
chr14_25506802_25506986	0.70	Zmiz1	zinc finger, MIZ-type containing 1	4239	0.18
chr14_31128387_31128552	0.70	Smim4	small integral membrane protein 4	369	0.76
chr6_7882729_7882890	0.70	Gm22276	predicted gene, 22276	3246	0.2
chr19_7180817_7180970	0.70	Otub1	OTU domain, ubiquitin aldehyde binding 1	19571	0.12
chr15_99716487_99716652	0.69	Gpd1	glycerol-3-phosphate dehydrogenase 1 (soluble)	946	0.3
chr16_77551147_77551350	0.68	Gm37606	predicted gene, 37606	10402	0.12
chr5_39219850_39220015	0.67	Gm40293	predicted gene, 40293	87152	0.08
chr15_88850581_88850743	0.67	Pim3	proviral integration site 3	11524	0.13
chr10_81057523_81057689	0.67	Sgta	small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha	2509	0.12
chr15_81523272_81523474	0.66	Gm5218	predicted gene 5218	23828	0.11
chr7_67709950_67710121	0.66	Ttc23	tetratricopeptide repeat domain 23	15226	0.13
chr11_59787617_59787784	0.66	Pld6	phospholipase D family, member 6	55	0.95
chr4_148868111_148868290	0.65	Casz1	castor zinc finger 1	21181	0.18
chr9_26924278_26924451	0.65	Gm1110	predicted gene 1110	1253	0.44
chr11_101066041_101066195	0.65	Naglu	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	3894	0.1
chr4_136168101_136168252	0.64	E2f2	E2F transcription factor 2	4218	0.16
chr11_59802025_59802176	0.63	Flcn	folliculin	7488	0.1
chr15_38569454_38569605	0.63	Gm29697	predicted gene, 29697	4467	0.14
chr2_132639484_132639653	0.63	AU019990	expressed sequence AU019990	6313	0.14
chr7_49351868_49352264	0.63	Gm44913	predicted gene 44913	5972	0.24
chr13_92846534_92846735	0.62	Mtx3	metaxin 3	1436	0.47
chr2_148022052_148022231	0.62	9030622O22Rik	RIKEN cDNA 9030622O22 gene	16129	0.17
chr8_125931903_125932065	0.62	Map3k21	mitogen-activated protein kinase kinase kinase 21	21534	0.17
chr11_60015685_60015836	0.62	Pemt	phosphatidylethanolamine N-methyltransferase	5466	0.18
chr10_80256725_80256907	0.60	Gamt	guanidinoacetate methyltransferase	2473	0.11
chr6_29650247_29650407	0.60	Tnpo3	transportin 3	40440	0.11
chr15_90992378_90992671	0.59	Kif21a	kinesin family member 21A	26122	0.16
chr14_76812275_76812477	0.59	Gm48968	predicted gene, 48968	20445	0.17
chr9_107289417_107289626	0.59	Mapkapk3	mitogen-activated protein kinase-activated protein kinase 3	177	0.89
chr6_124813558_124813734	0.58	Tpi1	triosephosphate isomerase 1	508	0.53
chr16_30064275_30064431	0.58	Hes1	hes family bHLH transcription factor 1	31	0.97
chr13_113168060_113168232	0.58	Gzmk	granzyme K	12751	0.12
chr18_11050629_11050793	0.57	Gata6os	GATA binding protein 6, opposite strand	776	0.58
chr8_111148892_111149043	0.57	9430091E24Rik	RIKEN cDNA 9430091E24 gene	3487	0.18
chr12_3862523_3862680	0.57	Dnmt3aos	DNA methyltransferase 3A, opposite strand	357	0.82
chr3_9599812_9599994	0.57	Zfp704	zinc finger protein 704	10182	0.23
chr11_3931044_3931195	0.56	Tcn2	transcobalamin 2	670	0.52
chr5_122239684_122239867	0.56	Tctn1	tectonic family member 1	11903	0.12
chr17_47463129_47463289	0.55	1700001C19Rik	RIKEN cDNA 1700001C19 gene	25833	0.1
chr11_60932286_60932492	0.55	Map2k3	mitogen-activated protein kinase kinase 3	323	0.62
chr18_61647742_61648023	0.55	Mir145a	microRNA 145a	12	0.95
chr15_74704343_74704514	0.54	4933427E11Rik	RIKEN cDNA 4933427E11 gene	4733	0.09
chr7_15980408_15980576	0.54	Bicra	BRD4 interacting chromatin remodeling complex associated protein	1767	0.22
chr2_114775396_114775571	0.53	Gm13975	predicted gene 13975	67371	0.11
chr9_46112348_46112526	0.53	Sik3	SIK family kinase 3	10693	0.18
chr5_8992782_8992933	0.53	Crot	carnitine O-octanoyltransferase	4185	0.14
chr18_84376797_84376986	0.53	Gm37216	predicted gene, 37216	745	0.73
chr6_126106995_126107182	0.52	Ntf3	neurotrophin 3	57872	0.15
chr7_141456887_141457063	0.52	Pnpla2	patatin-like phospholipase domain containing 2	43	0.92
chr19_37583528_37583701	0.52	Exoc6	exocyst complex component 6	33155	0.16
chr9_20730600_20730850	0.52	Olfm2	olfactomedin 2	2496	0.23
chr1_84758953_84759122	0.51	Trip12	thyroid hormone receptor interactor 12	1147	0.47
chr16_31996383_31996610	0.51	Hmgb1-ps6	high mobility group box 1, pseudogene 6	4628	0.09
chr6_140674472_140674632	0.51	Aebp2	AE binding protein 2	27735	0.16
chr16_87710092_87710297	0.51	Bach1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	11190	0.21
chr13_28507894_28508045	0.51	Gm6081	predicted gene 6081	3263	0.28
chr12_112229300_112229492	0.50	Gm20368	predicted gene, 20368	24243	0.16
chr4_133563360_133563542	0.50	Gm23158	predicted gene, 23158	4502	0.11
chr4_150371789_150371980	0.50	Rere	arginine glutamic acid dipeptide (RE) repeats	34510	0.15
chr6_71270702_71270888	0.49	Mir8112	microRNA 8112	876	0.31
chr13_119791388_119791687	0.49	Zfp131	zinc finger protein 131	648	0.58
chr9_56937902_56938069	0.49	Imp3	IMP3, U3 small nucleolar ribonucleoprotein	510	0.64
chr8_111726628_111726784	0.48	Bcar1	breast cancer anti-estrogen resistance 1	5399	0.19
chr19_5038738_5038898	0.48	B4gat1	beta-1,4-glucuronyltransferase 1	8	0.53
chr10_7268902_7269053	0.47	Cnksr3	Cnksr family member 3	56740	0.14
chr11_67024896_67025068	0.47	Tmem220	transmembrane protein 220	172	0.93
chrX_7679840_7680006	0.47	Magix	MAGI family member, X-linked	1166	0.23
chr2_35233951_35234102	0.47	Gm13605	predicted gene 13605	9493	0.14
chr1_120061492_120061672	0.47	Tmem37	transmembrane protein 37	12492	0.17
chr10_44474418_44474575	0.47	Prdm1	PR domain containing 1, with ZNF domain	15748	0.18
chr17_25231680_25231997	0.46	Gnptg	N-acetylglucosamine-1-phosphotransferase, gamma subunit	8278	0.08
chr7_142622273_142622480	0.46	Gm33148	predicted gene, 33148	30632	0.08
chr2_26576085_26576254	0.46	Egfl7	EGF-like domain 7	3845	0.11
chr13_45570061_45570212	0.46	Gmpr	guanosine monophosphate reductase	23983	0.23
chr15_83772573_83772737	0.46	Mpped1	metallophosphoesterase domain containing 1	6812	0.24
chr13_45406872_45407023	0.46	Mylip	myosin regulatory light chain interacting protein	16020	0.2
chr12_75473113_75473300	0.45	Gm47690	predicted gene, 47690	35539	0.17
chr17_29058068_29058237	0.45	Gm41556	predicted gene, 41556	77	0.94
chr6_91424316_91424467	0.45	Gm4575	predicted gene 4575	4492	0.12
chr8_71306147_71306308	0.45	Myo9b	myosin IXb	27590	0.11
chr4_8400514_8400698	0.44	Gm37386	predicted gene, 37386	53641	0.14
chr11_100819720_100819912	0.44	Stat5b	signal transducer and activator of transcription 5B	2712	0.19
chr6_31081370_31081547	0.44	Lncpint	long non-protein coding RNA, Trp53 induced transcript	6146	0.12
chr18_46455190_46455491	0.44	Mospd4	motile sperm domain containing 4	10450	0.14
chr18_12869001_12869319	0.44	Osbpl1a	oxysterol binding protein-like 1A	53	0.97
chr17_85040351_85040697	0.44	Slc3a1	solute carrier family 3, member 1	12148	0.18
chr5_121775382_121775533	0.44	Atxn2	ataxin 2	2472	0.19
chr8_124750214_124750687	0.44	Fam89a	family with sequence similarity 89, member A	1382	0.3
chr7_79466451_79467019	0.44	Gm10616	predicted gene 10616	326	0.49
chr13_45917431_45917595	0.44	4930453C13Rik	RIKEN cDNA 4930453C13 gene	18527	0.2
chr10_120391230_120391401	0.43	9230105E05Rik	RIKEN cDNA 9230105E05 gene	1792	0.33
chr15_67405630_67405995	0.43	1700012I11Rik	RIKEN cDNA 1700012I11 gene	179043	0.03
chr15_84121144_84121320	0.43	Pnpla5	patatin-like phospholipase domain containing 5	1943	0.2
chr9_71663328_71663759	0.43	Cgnl1	cingulin-like 1	15193	0.21
chr12_109501140_109501291	0.43	Gm34081	predicted gene, 34081	15525	0.06
chr7_80202018_80202199	0.43	Sema4b	sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B	3572	0.12
chr16_18877584_18877767	0.42	Hira	histone cell cycle regulator	263	0.79
chr9_23030248_23030409	0.42	Bmper	BMP-binding endothelial regulator	192748	0.03
chr11_61974443_61974594	0.42	Gm12274	predicted gene 12274	168	0.92
chr10_75937006_75937161	0.42	Chchd10	coiled-coil-helix-coiled-coil-helix domain containing 10	137	0.81

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hes5_Hes7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:1903261	regulation of serine phosphorylation of STAT3 protein(GO:1903261)
0.2	0.6	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608)
0.2	0.6	GO:1901856	negative regulation of cellular respiration(GO:1901856)
0.2	0.7	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.2	1.1	GO:0042866	pyruvate biosynthetic process(GO:0042866)
0.2	0.6	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.1	0.3	GO:0021564	vagus nerve development(GO:0021564)
0.1	1.8	GO:0046548	retinal rod cell development(GO:0046548)
0.1	0.4	GO:0046544	development of secondary male sexual characteristics(GO:0046544)
0.1	0.4	GO:0097503	sialylation(GO:0097503)
0.1	0.3	GO:2001016	positive regulation of skeletal muscle cell differentiation(GO:2001016)
0.1	0.3	GO:0006868	glutamine transport(GO:0006868)
0.1	0.7	GO:0010635	regulation of mitochondrial fusion(GO:0010635)
0.1	0.4	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.1	0.5	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.1	0.6	GO:0044351	macropinocytosis(GO:0044351)
0.1	0.7	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.1	0.3	GO:0015889	cobalamin transport(GO:0015889)
0.1	0.4	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.1	0.3	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.1	0.3	GO:0021586	pons maturation(GO:0021586)
0.1	0.5	GO:0032792	negative regulation of CREB transcription factor activity(GO:0032792)
0.1	0.4	GO:1902570	protein localization to nucleolus(GO:1902570)
0.1	0.2	GO:0045583	regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.1	0.3	GO:0061074	regulation of neural retina development(GO:0061074)
0.1	0.2	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
0.1	0.3	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.1	0.3	GO:0065001	specification of axis polarity(GO:0065001)
0.1	0.2	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.1	0.3	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.1	0.9	GO:0033235	positive regulation of protein sumoylation(GO:0033235)
0.1	0.9	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.1	0.3	GO:0006538	glutamate catabolic process(GO:0006538)
0.1	0.2	GO:0060178	regulation of exocyst localization(GO:0060178)
0.1	0.3	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.1	0.1	GO:0006533	aspartate catabolic process(GO:0006533)
0.1	0.4	GO:0034626	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.1	0.5	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.1	0.2	GO:0046864	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.1	0.2	GO:0061589	calcium activated phosphatidylserine scrambling(GO:0061589)
0.1	0.2	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	0.3	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1	0.3	GO:1902774	late endosome to lysosome transport(GO:1902774)
0.1	0.2	GO:0097428	protein maturation by iron-sulfur cluster transfer(GO:0097428)
0.1	0.1	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061419)
0.1	0.2	GO:0006116	NADH oxidation(GO:0006116)
0.1	0.4	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.1	0.2	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.1	0.2	GO:0003358	noradrenergic neuron development(GO:0003358)
0.1	0.2	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	0.2	GO:0006566	threonine metabolic process(GO:0006566)
0.1	0.3	GO:0060087	relaxation of vascular smooth muscle(GO:0060087)
0.0	0.1	GO:0060486	Clara cell differentiation(GO:0060486)
0.0	0.1	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.1	GO:0040031	snRNA modification(GO:0040031)
0.0	0.2	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.1	GO:0033058	directional locomotion(GO:0033058)
0.0	0.2	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.9	GO:0060219	camera-type eye photoreceptor cell differentiation(GO:0060219)
0.0	0.2	GO:1904491	protein localization to ciliary transition zone(GO:1904491)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.3	GO:0043045	DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538)
0.0	0.2	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0	1.9	GO:0007157	heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.3	GO:0046498	S-adenosylhomocysteine metabolic process(GO:0046498)
0.0	0.3	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	1.4	GO:1903146	regulation of mitophagy(GO:1903146)
0.0	0.1	GO:0033030	negative regulation of neutrophil apoptotic process(GO:0033030)
0.0	0.0	GO:0060137	maternal process involved in parturition(GO:0060137)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.1	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.1	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.3	GO:0015816	glycine transport(GO:0015816)
0.0	0.5	GO:0044458	motile cilium assembly(GO:0044458)
0.0	0.2	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
0.0	0.2	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.2	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.3	GO:0030853	negative regulation of granulocyte differentiation(GO:0030853)
0.0	0.1	GO:0046878	positive regulation of saliva secretion(GO:0046878)
0.0	0.0	GO:1903431	positive regulation of cell maturation(GO:1903431)
0.0	0.3	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0002309	T cell proliferation involved in immune response(GO:0002309)
0.0	0.1	GO:1902896	terminal web assembly(GO:1902896)
0.0	0.1	GO:0022009	central nervous system vasculogenesis(GO:0022009)
0.0	0.1	GO:0097476	motor neuron migration(GO:0097475) spinal cord motor neuron migration(GO:0097476)
0.0	0.4	GO:0006098	pentose-phosphate shunt(GO:0006098)
0.0	0.1	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.0	0.1	GO:0034047	regulation of protein phosphatase type 2A activity(GO:0034047)
0.0	0.1	GO:2000302	positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.0	0.1	GO:1902262	apoptotic process involved in patterning of blood vessels(GO:1902262)
0.0	0.1	GO:0007403	glial cell fate determination(GO:0007403)
0.0	0.1	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847)
0.0	0.1	GO:0010989	negative regulation of low-density lipoprotein particle clearance(GO:0010989)
0.0	0.2	GO:0006884	cell volume homeostasis(GO:0006884)
0.0	0.0	GO:0044778	meiotic DNA integrity checkpoint(GO:0044778)
0.0	0.1	GO:1903898	negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0	0.1	GO:0048312	intracellular distribution of mitochondria(GO:0048312)
0.0	0.1	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187)
0.0	0.1	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0	0.1	GO:0050703	interleukin-1 alpha secretion(GO:0050703)
0.0	0.1	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.0	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.2	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.1	GO:0030311	poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.0	0.0	GO:0061205	paramesonephric duct development(GO:0061205)
0.0	0.1	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.2	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0	0.0	GO:0090283	regulation of protein glycosylation in Golgi(GO:0090283)
0.0	0.3	GO:0010592	positive regulation of lamellipodium assembly(GO:0010592)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.2	GO:0072540	T-helper 17 cell lineage commitment(GO:0072540)
0.0	0.1	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.1	GO:0031443	fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.0	0.0	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0035630	bone mineralization involved in bone maturation(GO:0035630)
0.0	0.5	GO:0006921	cellular component disassembly involved in execution phase of apoptosis(GO:0006921) apoptotic nuclear changes(GO:0030262)
0.0	0.1	GO:0032074	negative regulation of nuclease activity(GO:0032074)
0.0	0.2	GO:0009992	cellular water homeostasis(GO:0009992)
0.0	0.1	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.0	0.2	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.0	GO:0071288	cellular response to mercury ion(GO:0071288)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.3	GO:0006336	DNA replication-independent nucleosome assembly(GO:0006336) DNA replication-independent nucleosome organization(GO:0034724)
0.0	0.1	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.3	GO:0006206	pyrimidine nucleobase metabolic process(GO:0006206)
0.0	0.3	GO:0016339	calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.0	0.1	GO:1904219	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.2	GO:0014041	regulation of neuron maturation(GO:0014041)
0.0	0.1	GO:1903300	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.1	GO:0045006	DNA deamination(GO:0045006)
0.0	0.1	GO:0046078	dUMP metabolic process(GO:0046078)
0.0	0.1	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.3	GO:0070633	transepithelial transport(GO:0070633)
0.0	0.2	GO:0060576	intestinal epithelial cell development(GO:0060576)
0.0	0.4	GO:0035066	positive regulation of histone acetylation(GO:0035066)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.1	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.1	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.0	0.1	GO:0010693	negative regulation of alkaline phosphatase activity(GO:0010693)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.2	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.0	0.2	GO:1903405	protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.0	0.1	GO:0010481	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.0	0.1	GO:0071351	cellular response to interleukin-18(GO:0071351)
0.0	0.1	GO:0032782	bile acid secretion(GO:0032782)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.0	GO:0097491	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491) neural crest cell migration involved in autonomic nervous system development(GO:1901166)
0.0	0.1	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.1	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.3	GO:0072337	modified amino acid transport(GO:0072337)
0.0	0.0	GO:0007228	positive regulation of hh target transcription factor activity(GO:0007228)
0.0	0.1	GO:0035728	response to hepatocyte growth factor(GO:0035728) cellular response to hepatocyte growth factor stimulus(GO:0035729)
0.0	0.1	GO:1900364	negative regulation of mRNA polyadenylation(GO:1900364)
0.0	0.2	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.0	0.2	GO:0097034	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0	0.0	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.0	0.0	GO:0032349	positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.0	0.0	GO:0090258	negative regulation of mitochondrial fission(GO:0090258)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.1	GO:1904354	negative regulation of telomere capping(GO:1904354)
0.0	0.5	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.0	GO:0034442	regulation of lipoprotein oxidation(GO:0034442)
0.0	0.2	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0	0.0	GO:0036016	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.1	GO:2001224	positive regulation of neuron migration(GO:2001224)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.0	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.0	GO:0036151	phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0	0.0	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.0	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity(GO:0035509)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.0	GO:2000020	positive regulation of male gonad development(GO:2000020)
0.0	0.0	GO:0046684	response to pyrethroid(GO:0046684)
0.0	0.0	GO:0043309	regulation of eosinophil degranulation(GO:0043309)
0.0	0.1	GO:0061635	regulation of protein complex stability(GO:0061635)
0.0	0.0	GO:0071335	hair follicle cell proliferation(GO:0071335)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.3	GO:1903077	negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376)
0.0	0.1	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.0	GO:2000969	positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.0	0.1	GO:0071361	cellular response to ethanol(GO:0071361)
0.0	0.2	GO:0051457	maintenance of protein location in nucleus(GO:0051457)
0.0	0.0	GO:0090154	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0	0.0	GO:2000847	negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.0	0.0	GO:0003223	ventricular compact myocardium morphogenesis(GO:0003223)
0.0	0.1	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.0	0.0	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.0	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.1	GO:1901387	positive regulation of voltage-gated calcium channel activity(GO:1901387)
0.0	0.0	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.0	0.0	GO:0043369	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment(GO:0043369)
0.0	0.0	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.0	GO:0034653	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0	0.0	GO:0019348	dolichol metabolic process(GO:0019348)
0.0	0.1	GO:0010993	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0	0.2	GO:0006264	mitochondrial DNA replication(GO:0006264)
0.0	0.0	GO:0046439	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0061370	testosterone biosynthetic process(GO:0061370)
0.0	0.1	GO:0033314	mitotic DNA replication checkpoint(GO:0033314)
0.0	0.0	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.1	GO:0044818	mitotic G2 DNA damage checkpoint(GO:0007095) mitotic G2/M transition checkpoint(GO:0044818)
0.0	0.1	GO:0071763	nuclear membrane organization(GO:0071763)
0.0	0.1	GO:1904321	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.0	0.1	GO:0071493	cellular response to UV-B(GO:0071493)
0.0	0.1	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.0	0.1	GO:0036010	protein localization to endosome(GO:0036010)
0.0	0.2	GO:0071880	adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0	0.0	GO:0060988	lipid tube assembly(GO:0060988)
0.0	0.4	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0	0.0	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:1901533	negative regulation of hematopoietic progenitor cell differentiation(GO:1901533)
0.0	0.0	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0	0.0	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0	0.0	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
0.0	0.0	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0	0.1	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.0	GO:0009642	response to light intensity(GO:0009642)
0.0	0.0	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.0	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.0	0.1	GO:0071294	cellular response to zinc ion(GO:0071294)
0.0	0.0	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	0.0	GO:0090170	regulation of Golgi inheritance(GO:0090170)
0.0	0.1	GO:0002934	desmosome organization(GO:0002934)
0.0	0.2	GO:0034198	cellular response to amino acid starvation(GO:0034198)
0.0	0.1	GO:0001675	acrosome assembly(GO:0001675)
0.0	0.0	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0006203	dGTP catabolic process(GO:0006203)
0.0	0.1	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
0.0	0.0	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0045075	interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.0	0.1	GO:0043981	histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
0.0	0.0	GO:0072710	response to hydroxyurea(GO:0072710) cellular response to hydroxyurea(GO:0072711)
0.0	0.1	GO:0060075	regulation of resting membrane potential(GO:0060075)
0.0	0.0	GO:0016081	synaptic vesicle docking(GO:0016081)
0.0	0.1	GO:0071670	smooth muscle cell chemotaxis(GO:0071670)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:0035838	growing cell tip(GO:0035838)
0.1	0.9	GO:0016589	NURF complex(GO:0016589)
0.1	0.8	GO:0000138	Golgi trans cisterna(GO:0000138)
0.1	0.9	GO:0034464	BBSome(GO:0034464)
0.1	0.3	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.1	0.3	GO:0034457	Mpp10 complex(GO:0034457)
0.1	0.8	GO:0001650	fibrillar center(GO:0001650)
0.1	0.3	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.1	0.3	GO:0008622	epsilon DNA polymerase complex(GO:0008622)
0.1	0.2	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.1	0.2	GO:0005967	mitochondrial pyruvate dehydrogenase complex(GO:0005967)
0.1	0.2	GO:1990726	Lsm1-7-Pat1 complex(GO:1990726)
0.1	0.2	GO:1990131	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.1	0.2	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.2	GO:0070876	SOSS complex(GO:0070876)
0.0	0.2	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.2	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.7	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.2	GO:0000235	astral microtubule(GO:0000235)
0.0	0.2	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)
0.0	0.1	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.0	0.4	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.2	GO:0031209	SCAR complex(GO:0031209)
0.0	0.1	GO:0072487	MSL complex(GO:0072487)
0.0	0.2	GO:0033263	CORVET complex(GO:0033263)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.2	GO:0001940	male pronucleus(GO:0001940)
0.0	0.3	GO:0032433	filopodium tip(GO:0032433)
0.0	0.3	GO:0036038	MKS complex(GO:0036038)
0.0	0.9	GO:0001917	photoreceptor inner segment(GO:0001917)
0.0	0.1	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.6	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0044462	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	1.1	GO:0005811	lipid particle(GO:0005811)
0.0	0.4	GO:0090544	BAF-type complex(GO:0090544)
0.0	0.3	GO:0005614	interstitial matrix(GO:0005614)
0.0	0.1	GO:0001674	female germ cell nucleus(GO:0001674)
0.0	0.2	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.2	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.0	0.2	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.1	GO:0098563	integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563)
0.0	0.1	GO:0005767	secondary lysosome(GO:0005767)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.0	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0000322	storage vacuole(GO:0000322)
0.0	0.3	GO:0035145	exon-exon junction complex(GO:0035145)
0.0	0.6	GO:0046658	anchored component of plasma membrane(GO:0046658)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.0	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.0	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
0.0	0.1	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.3	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.0	0.0	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0	0.0	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.0	0.1	GO:0032039	integrator complex(GO:0032039)
0.0	0.6	GO:0016529	sarcoplasmic reticulum(GO:0016529)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0043398	HLH domain binding(GO:0043398)
0.2	0.7	GO:0030572	cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.2	0.8	GO:0010853	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.1	0.8	GO:0022858	L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.1	0.8	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.1	0.3	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.1	0.3	GO:0030519	snoRNP binding(GO:0030519)
0.1	0.3	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.1	1.2	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.1	0.2	GO:0061513	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1	0.7	GO:0034522	pinocarveol dehydrogenase activity(GO:0018446) chloral hydrate dehydrogenase activity(GO:0018447) hydroxymethylmethylsilanediol oxidase activity(GO:0018448) 1-phenylethanol dehydrogenase activity(GO:0018449) myrtenol dehydrogenase activity(GO:0018450) cis-1,2-dihydroxy-1,2-dihydro-8-carboxynaphthalene dehydrogenase activity(GO:0034522) 3-hydroxy-4-methyloctanoyl-CoA dehydrogenase activity(GO:0034582) 2-hydroxy-4-isopropenylcyclohexane-1-carboxyl-CoA dehydrogenase activity(GO:0034778) cis-9,10-dihydroanthracene-9,10-diol dehydrogenase activity(GO:0034817) citronellol dehydrogenase activity(GO:0034821) naphthyl-2-hydroxymethyl-succinyl-CoA dehydrogenase activity(GO:0034847) 2,4,4-trimethyl-1-pentanol dehydrogenase activity(GO:0034863) 2,4,4-trimethyl-3-hydroxypentanoyl-CoA dehydrogenase activity(GO:0034868) 1-hydroxy-4,4-dimethylpentan-3-one dehydrogenase activity(GO:0034871) endosulfan diol dehydrogenase activity(GO:0034891) endosulfan hydroxyether dehydrogenase activity(GO:0034901) 3-hydroxy-2-methylhexanoyl-CoA dehydrogenase activity(GO:0034918) 3-hydroxy-2,6-dimethyl-5-methylene-heptanoyl-CoA dehydrogenase activity(GO:0034944) versicolorin reductase activity(GO:0042469) ketoreductase activity(GO:0045703)
0.1	0.2	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.1	0.2	GO:0016941	natriuretic peptide receptor activity(GO:0016941)
0.1	0.2	GO:0019959	interleukin-8 binding(GO:0019959)
0.1	0.3	GO:0004565	beta-galactosidase activity(GO:0004565)
0.1	0.3	GO:0004645	phosphorylase activity(GO:0004645)
0.1	0.4	GO:0102337	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.1	0.3	GO:0070728	leucine binding(GO:0070728)
0.1	0.2	GO:0050692	DBD domain binding(GO:0050692)
0.1	0.3	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1	0.3	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.1	0.2	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	2.0	GO:0005044	scavenger receptor activity(GO:0005044)
0.0	0.3	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.6	GO:0016500	protein-hormone receptor activity(GO:0016500)
0.0	0.4	GO:0004708	MAP kinase kinase activity(GO:0004708)
0.0	0.3	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.3	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0	0.4	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.1	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.2	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.6	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.1	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.6	GO:0009931	calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.0	0.2	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.0	0.1	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.0	0.5	GO:0070577	lysine-acetylated histone binding(GO:0070577)
0.0	0.4	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.4	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.3	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.1	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.3	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.5	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.2	GO:0034791	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.1	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.2	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:1904288	BAT3 complex binding(GO:1904288)
0.0	0.2	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	0.4	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.4	GO:0005328	neurotransmitter:sodium symporter activity(GO:0005328)
0.0	0.1	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.1	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.3	GO:0072349	modified amino acid transmembrane transporter activity(GO:0072349)
0.0	0.1	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.0	0.1	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.0	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.1	GO:0019145	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.2	GO:0070034	telomerase RNA binding(GO:0070034)
0.0	0.3	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.2	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.3	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.1	GO:0035727	lysophosphatidic acid binding(GO:0035727)
0.0	0.2	GO:0004844	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.1	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.3	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.1	GO:0042015	interleukin-20 binding(GO:0042015)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.0	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.0	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.0	0.2	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0048038	quinone binding(GO:0048038)
0.0	0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	1.0	GO:0004843	thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0	0.0	GO:0070137	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.2	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.0	GO:0003865	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0031433	telethonin binding(GO:0031433)
0.0	0.2	GO:0005123	death receptor binding(GO:0005123)
0.0	0.2	GO:1990939	ATP-dependent microtubule motor activity(GO:1990939)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.3	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0015922	aspartate oxidase activity(GO:0015922)
0.0	0.2	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.0	0.2	GO:0008327	methyl-CpG binding(GO:0008327)
0.0	0.0	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.1	GO:0010314	phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.2	GO:0008143	poly(A) binding(GO:0008143)
0.0	0.1	GO:0052758	4-methyloctanoyl-CoA dehydrogenase activity(GO:0034580) naphthyl-2-methyl-succinyl-CoA dehydrogenase activity(GO:0034845) 2-methylhexanoyl-CoA dehydrogenase activity(GO:0034916) propionyl-CoA dehydrogenase activity(GO:0043820) thiol-driven fumarate reductase activity(GO:0043830) coenzyme F420-dependent 2,4,6-trinitrophenol reductase activity(GO:0052758) coenzyme F420-dependent 2,4,6-trinitrophenol hydride reductase activity(GO:0052759) coenzyme F420-dependent 2,4-dinitrophenol reductase activity(GO:0052760)
0.0	0.1	GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.0	0.0	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.2	GO:0032266	phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.0	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0031681	G-protein beta-subunit binding(GO:0031681)
0.0	0.0	GO:0031014	troponin T binding(GO:0031014)
0.0	0.0	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0051183	vitamin transporter activity(GO:0051183)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.0	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.0	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.3	GO:0003887	DNA-directed DNA polymerase activity(GO:0003887)
0.0	0.9	GO:0030165	PDZ domain binding(GO:0030165)
0.0	0.0	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.1	1.1	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.1	0.3	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.1	0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.7	PID CONE PATHWAY	Visual signal transduction: Cones
0.0	0.3	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	0.6	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.0	0.1	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.7	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway
0.0	0.4	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.7	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	1.2	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	0.5	ST P38 MAPK PATHWAY	p38 MAPK Pathway
0.0	0.3	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.4	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.0	0.7	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.0	0.2	PID REG GR PATHWAY	Glucocorticoid receptor regulatory network
0.0	0.1	PID IL1 PATHWAY	IL1-mediated signaling events
0.0	0.0	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.3	PID ECADHERIN NASCENT AJ PATHWAY	E-cadherin signaling in the nascent adherens junction
0.0	0.5	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.0	0.2	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.0	0.1	PID IL12 2PATHWAY	IL12-mediated signaling events
0.0	0.0	PID ATF2 PATHWAY	ATF-2 transcription factor network
0.0	0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	Genes involved in activated TAK1 mediates p38 MAPK activation
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.4	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.9	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.0	0.3	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.4	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.1	REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.0	0.6	REACTOME IL1 SIGNALING	Genes involved in Interleukin-1 signaling
0.0	0.3	REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION	Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0	0.0	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.5	REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE	Genes involved in Cytochrome P450 - arranged by substrate type
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.3	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.5	REACTOME MEIOTIC SYNAPSIS	Genes involved in Meiotic Synapsis
0.0	0.2	REACTOME GLUCOSE TRANSPORT	Genes involved in Glucose transport
0.0	0.2	REACTOME SIGNALING BY NOTCH4	Genes involved in Signaling by NOTCH4
0.0	0.3	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.0	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
0.0	0.2	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	0.2	REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE	Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0	0.1	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.4	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	1.1	REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS	Genes involved in Glycerophospholipid biosynthesis
0.0	0.1	REACTOME G1 PHASE	Genes involved in G1 Phase
0.0	0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.3	REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY	Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.0	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions

Results for Hes5_Hes7

Z-value: 2.64

Motif logo

Transcription factors associated with Hes5_Hes7

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Hes5_Hes7 motif across conditions

Conditions sorted by the z-value of the Hes5_Hes7 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hes5_Hes7

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: