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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hif1a

Z-value: 1.04

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Transcription factors associated with Hif1a

Gene Symbol	Gene ID	Gene Info
Hif1a Ensembl NCBI MGI UniProt	ENSMUSG00000021109.7	Hif1a

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hif1a	chr12_73923859_73924010	2668	0.215132	-0.83	4.2e-02	Click!
Hif1a	chr12_73907952_73908112	128	0.956916	0.82	4.6e-02	Click!
Hif1a	chr12_73907445_73907608	378	0.843174	0.51	3.0e-01	Click!
Hif1a	chr12_73909283_73909641	1558	0.349825	-0.50	3.1e-01	Click!
Hif1a	chr12_73907704_73907868	118	0.959539	0.46	3.6e-01	Click!

Activity of the Hif1a motif across conditions

Conditions sorted by the z-value of the Hif1a motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_127355690_127355901	0.65	Gm23734	predicted gene, 23734	19336	0.15
chr3_139205794_139206161	0.48	Stpg2	sperm tail PG rich repeat containing 2	84	0.98
chr16_43979812_43979963	0.48	Zdhhc23	zinc finger, DHHC domain containing 23	96	0.96
chr10_83337805_83337991	0.46	Slc41a2	solute carrier family 41, member 2	16	0.97
chr8_44938067_44938242	0.42	Fat1	FAT atypical cadherin 1	2707	0.27
chr11_53463790_53463971	0.41	Gm12212	predicted gene 12212	267	0.77
chr11_16752814_16752965	0.41	Egfr	epidermal growth factor receptor	659	0.72
chr14_65262428_65262601	0.39	Fzd3	frizzled class receptor 3	51	0.97
chr15_83367361_83367678	0.35	1700001L05Rik	RIKEN cDNA 1700001L05 gene	237	0.9
chr14_33319851_33320021	0.33	Arhgap22	Rho GTPase activating protein 22	233	0.93
chr11_88718358_88718518	0.29	Msi2	musashi RNA-binding protein 2	75	0.69
chr13_93499654_93499810	0.28	Jmy	junction-mediating and regulatory protein	5	0.98
chr18_76378806_76378977	0.28	Gm50360	predicted gene, 50360	57067	0.14
chr7_45466827_45467004	0.27	Bax	BCL2-associated X protein	17	0.91
chr4_154946732_154946894	0.27	Hes5	hes family bHLH transcription factor 5	14110	0.11
chr7_12780664_12780815	0.26	Zscan18	zinc finger and SCAN domain containing 18	85	0.53
chr10_7976561_7976927	0.25	Tab2	TGF-beta activated kinase 1/MAP3K7 binding protein 2	20514	0.19
chr11_6416246_6416529	0.25	Ppia	peptidylprolyl isomerase A	75	0.94
chr13_32338323_32338641	0.25	Gmds	GDP-mannose 4, 6-dehydratase	103	0.79
chr5_129020390_129020558	0.25	Ran	RAN, member RAS oncogene family	202	0.94
chr6_83768773_83768930	0.24	Tex261	testis expressed gene 261	3624	0.1
chr7_46845708_46845871	0.23	Ldha	lactate dehydrogenase A	50	0.95
chr6_134566862_134567026	0.23	Lrp6	low density lipoprotein receptor-related protein 6	21	0.98
chr10_44005716_44005885	0.23	Crybg1	crystallin beta-gamma domain containing 1	1431	0.34
chr19_45749067_45749428	0.23	Gm15491	predicted gene 15491	261	0.52
chrX_75155692_75155860	0.22	Gm8503	predicted gene 8503	43	0.95
chr11_109500636_109500796	0.22	Gm22378	predicted gene, 22378	892	0.5
chr3_86223972_86224138	0.22	Lrba	LPS-responsive beige-like anchor	625	0.66
chr11_51852080_51852269	0.22	Jade2	jade family PHD finger 2	4951	0.2
chr12_16895014_16895177	0.22	Rock2	Rho-associated coiled-coil containing protein kinase 2	72	0.97
chr2_69897607_69897758	0.21	Ubr3	ubiquitin protein ligase E3 component n-recognin 3	379	0.79
chr2_164785787_164785954	0.21	Snx21	sorting nexin family member 21	47	0.93
chr4_20008188_20008393	0.21	Ttpa	tocopherol (alpha) transfer protein	67	0.97
chr17_50509012_50509163	0.21	Plcl2	phospholipase C-like 2	316	0.94
chr9_86464855_86465024	0.20	Ube2cbp	ubiquitin-conjugating enzyme E2C binding protein	11	0.97
chr7_116039868_116040228	0.20	1110004F10Rik	RIKEN cDNA 1110004F10 gene	336	0.79
chr5_110652988_110653519	0.20	Noc4l	NOC4 like	6	0.71
chr8_106893571_106893752	0.20	Utp4	UTP4 small subunit processome component	10	0.37
chr5_139460535_139460827	0.20	3110082I17Rik	RIKEN cDNA 3110082I17 gene	154	0.93
chr13_10360761_10361247	0.19	Chrm3	cholinergic receptor, muscarinic 3, cardiac	157	0.96
chr8_105852398_105852549	0.19	Cenpt	centromere protein T	419	0.64
chr4_41740767_41740935	0.19	Sigmar1	sigma non-opioid intracellular receptor 1	197	0.87
chr19_5829011_5829567	0.19	Neat1	nuclear paraspeckle assembly transcript 1 (non-protein coding)	1277	0.22
chr8_111094396_111094682	0.19	Pdpr	pyruvate dehydrogenase phosphatase regulatory subunit	91	0.94
chr11_98863504_98863667	0.19	Wipf2	WAS/WASL interacting protein family, member 2	53	0.95
chr12_110446883_110447049	0.18	Ppp2r5c	protein phosphatase 2, regulatory subunit B', gamma	154	0.95
chr7_5125880_5126049	0.18	Rasl2-9	RAS-like, family 2, locus 9	14	0.93
chr9_57940036_57940192	0.18	Sema7a	sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A	1	0.97
chr16_17210099_17210269	0.18	Rimbp3	RIMS binding protein 3	1581	0.21
chr6_54816485_54816684	0.18	Znrf2	zinc and ring finger 2	332	0.91
chr10_80754904_80755061	0.18	Dot1l	DOT1-like, histone H3 methyltransferase (S. cerevisiae)	224	0.85
chr11_79145978_79146129	0.17	Ksr1	kinase suppressor of ras 1	354	0.89
chr6_38551988_38552146	0.17	Luc7l2	LUC7-like 2 (S. cerevisiae)	224	0.91
chr2_180119332_180119483	0.16	Osbpl2	oxysterol binding protein-like 2	3	0.96
chr14_24486976_24487144	0.16	Polr3a	polymerase (RNA) III (DNA directed) polypeptide A	2	0.54
chr7_112225527_112225875	0.16	Mical2	microtubule associated monooxygenase, calponin and LIM domain containing 2	155	0.97
chr5_129031100_129031253	0.16	Ran	RAN, member RAS oncogene family	10904	0.2
chr2_181680135_181680294	0.16	Tcea2	transcription elongation factor A (SII), 2	96	0.93
chr7_138538061_138538232	0.16	4930543N07Rik	RIKEN cDNA 4930543N07 gene	16084	0.26
chr17_27133587_27133748	0.16	Uqcc2	ubiquinol-cytochrome c reductase complex assembly factor 2	38	0.95
chr17_74338623_74338796	0.16	Spast	spastin	278	0.85
chr1_191388747_191388913	0.16	Ppp2r5a	protein phosphatase 2, regulatory subunit B', alpha	3504	0.2
chr6_29211843_29212020	0.16	Impdh1	inosine monophosphate dehydrogenase 1	318	0.84
chr19_4196660_4196821	0.15	Ppp1ca	protein phosphatase 1 catalytic subunit alpha	2091	0.09
chr15_31453304_31453493	0.15	Ropn1l	ropporin 1-like	339	0.45
chr8_95107420_95107577	0.15	Kifc3	kinesin family member C3	2926	0.14
chr11_72489944_72490114	0.15	Spns2	spinster homolog 2	125	0.95
chr7_51861626_51861818	0.15	Gas2	growth arrest specific 2	293	0.68
chr19_7398029_7398222	0.15	Rab11b-ps2	RAB11B, member RAS oncogene family, pseudogene 2	952	0.37
chr11_114826796_114826950	0.14	Gprc5c	G protein-coupled receptor, family C, group 5, member C	24279	0.11
chr5_139252311_139252489	0.14	Get4	golgi to ER traffic protein 4	30	0.97
chr6_48860509_48860678	0.14	Gm7932	predicted gene 7932	169	0.88
chr17_33747281_33747468	0.14	Rab11b	RAB11B, member RAS oncogene family	2471	0.14
chr16_16213091_16213252	0.14	Pkp2	plakophilin 2	147	0.96
chr7_67951713_67951868	0.14	Igf1r	insulin-like growth factor I receptor	1037	0.59
chr10_82630042_82630204	0.14	Tdg	thymine DNA glycosylase	247	0.89
chr1_135631615_135631792	0.14	Nav1	neuron navigator 1	45998	0.11
chr17_56325722_56325896	0.14	Kdm4b	lysine (K)-specific demethylase 4B	253	0.86
chr3_19310803_19310964	0.14	Pde7a	phosphodiesterase 7A	20	0.99
chr6_118479189_118479349	0.13	Zfp9	zinc finger protein 9	51	0.97
chr7_28179311_28179471	0.13	Dyrk1b	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1b	78	0.94
chr4_129924204_129924361	0.13	Spocd1	SPOC domain containing 1	4967	0.13
chr17_25837125_25837580	0.13	Rhbdl1	rhomboid like 1	57	0.89
chr6_100287706_100287857	0.13	Rybp	RING1 and YY1 binding protein	296	0.89
chr8_105279146_105279313	0.13	Nol3	nucleolar protein 3 (apoptosis repressor with CARD domain)	3089	0.08
chr11_61683998_61684190	0.13	Fam83g	family with sequence similarity 83, member G	3	0.97
chr7_142097951_142098107	0.13	Dusp8	dual specificity phosphatase 8	2186	0.13
chr13_66932977_66933151	0.13	Mterf3	mitochondrial transcription termination factor 3	3	0.65
chr16_20621460_20621649	0.13	Camk2n2	calcium/calmodulin-dependent protein kinase II inhibitor 2	267	0.75
chr9_94537390_94537600	0.12	Dipk2a	divergent protein kinase domain 2A	586	0.8
chr5_134639466_134639692	0.12	Eif4h	eukaryotic translation initiation factor 4H	89	0.95
chr11_59518331_59518501	0.12	Zkscan17	zinc finger with KRAB and SCAN domains 17	8215	0.1
chr16_35770249_35770414	0.12	Hspbap1	Hspb associated protein 1	44	0.94
chr9_89066820_89066977	0.12	Gm24463	predicted gene, 24463	8438	0.14
chr4_132763837_132763988	0.12	Rpa2	replication protein A2	4420	0.14
chr14_73325714_73325873	0.12	Rb1	RB transcriptional corepressor 1	29	0.98
chr13_51849179_51849522	0.12	Gadd45g	growth arrest and DNA-damage-inducible 45 gamma	2606	0.33
chr10_77418300_77418496	0.12	Adarb1	adenosine deaminase, RNA-specific, B1	128	0.96
chr6_112939448_112939605	0.12	Srgap3	SLIT-ROBO Rho GTPase activating protein 3	7228	0.15
chr1_40221808_40222119	0.12	Il1r1	interleukin 1 receptor, type I	3117	0.26
chr7_25396338_25396501	0.12	Lipe	lipase, hormone sensitive	40	0.93
chr11_120542125_120542287	0.12	Mcrip1	MAPK regulated corepressor interacting protein 1	7495	0.06
chr7_132287097_132287256	0.12	Chst15	carbohydrate sulfotransferase 15	8551	0.16
chr4_144901641_144901842	0.12	Dhrs3	dehydrogenase/reductase (SDR family) member 3	8522	0.21
chr15_100401091_100401280	0.11	Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	2058	0.2
chr13_113618547_113618702	0.11	Snx18	sorting nexin 18	60	0.97
chr8_84705414_84705592	0.11	Nfix	nuclear factor I/X	2213	0.16
chr17_47924756_47925097	0.11	Foxp4	forkhead box P4	281	0.86
chr3_88835111_88835270	0.11	Gon4l	gon-4-like (C.elegans)	41	0.95
chr16_55814810_55814983	0.11	Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta	3619	0.22
chr7_80027017_80027182	0.11	Zfp710	zinc finger protein 710	712	0.56
chr8_114773512_114773798	0.11	Wwox	WW domain-containing oxidoreductase	61488	0.13
chr6_29272524_29272714	0.11	Hilpda	hypoxia inducible lipid droplet associated	7	0.96
chr17_24753315_24753466	0.11	Hs3st6	heparan sulfate (glucosamine) 3-O-sulfotransferase 6	374	0.66
chr6_146888080_146888231	0.11	Ppfibp1	PTPRF interacting protein, binding protein 1 (liprin beta 1)	332	0.86
chr2_114654754_114655226	0.11	Dph6	diphthamine biosynthesis 6	26	0.92
chr4_142070841_142071028	0.11	Tmem51os1	Tmem51 opposite strand 1	13038	0.13
chr14_67933014_67933176	0.11	Dock5	dedicator of cytokinesis 5	337	0.92
chr6_97487494_97487819	0.11	Frmd4b	FERM domain containing 4B	147	0.96
chr5_27997662_27998174	0.11	Gm4865	predicted gene 4865	3388	0.22
chr3_89276379_89276658	0.11	Efna1	ephrin A1	3123	0.09
chr2_181459964_181460183	0.11	Zbtb46	zinc finger and BTB domain containing 46	647	0.57
chr16_11253479_11253674	0.10	Gspt1	G1 to S phase transition 1	633	0.47
chr4_62524756_62524940	0.10	Pole3	polymerase (DNA directed), epsilon 3 (p17 subunit)	190	0.77
chr4_141697170_141697329	0.10	Rsc1a1	regulatory solute carrier protein, family 1, member 1	11650	0.12
chr9_108808514_108808701	0.10	Nckipsd	NCK interacting protein with SH3 domain	186	0.88
chr15_85337324_85337483	0.10	Atxn10	ataxin 10	1158	0.51
chr7_143600068_143600237	0.10	Gm15579	predicted gene 15579	18	0.52
chr10_95940931_95941100	0.10	Eea1	early endosome antigen 1	258	0.91
chr11_116852385_116852543	0.10	Mfsd11	major facilitator superfamily domain containing 11	24	0.76
chr5_124446062_124446234	0.10	Kmt5a	lysine methyltransferase 5A	364	0.75
chr15_94543180_94543352	0.10	Pus7l	pseudouridylate synthase 7-like	220	0.67
chr11_3963860_3964038	0.10	Pes1	pescadillo ribosomal biogenesis factor 1	26	0.95
chr11_60811168_60811358	0.10	Shmt1	serine hydroxymethyltransferase 1 (soluble)	2	0.95
chr3_88775094_88775256	0.10	Syt11	synaptotagmin XI	11	0.51
chr7_30359743_30359928	0.10	Gm25259	predicted gene, 25259	2911	0.09
chr11_60731090_60731277	0.10	Mir5100	microRNA 5100	2520	0.1
chr12_105784205_105784562	0.10	Papola	poly (A) polymerase alpha	311	0.9
chr17_5176692_5176856	0.10	Gm15599	predicted gene 15599	64664	0.13
chr2_6118432_6118598	0.10	Proser2	proline and serine rich 2	11624	0.15
chr5_5559196_5559372	0.10	Gtpbp10	GTP-binding protein 10 (putative)	177	0.93
chr16_4908036_4908194	0.10	Mgrn1	mahogunin, ring finger 1	5096	0.12
chr4_46452273_46452437	0.10	Anp32b	acidic (leucine-rich) nuclear phosphoprotein 32 family, member B	1453	0.32
chr15_73724592_73724779	0.10	Ptp4a3	protein tyrosine phosphatase 4a3	113	0.96
chr15_88821550_88821729	0.09	Creld2	cysteine-rich with EGF-like domains 2	1993	0.22
chr2_118972791_118972987	0.09	Gm14089	predicted gene 14089	24179	0.11
chr3_110250186_110250444	0.09	C130013H08Rik	RIKEN cDNA C130013H08 gene	300	0.74
chr2_180042367_180042531	0.09	Psma7	proteasome subunit alpha 7	16	0.52
chrX_134276921_134277269	0.09	Trmt2b	TRM2 tRNA methyltransferase 2B	111	0.96
chrX_101640210_101640705	0.09	Ogt	O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase)	317	0.87
chr9_65032284_65032455	0.09	Dpp8	dipeptidylpeptidase 8	45	0.97
chr14_18238484_18238667	0.09	Nr1d2	nuclear receptor subfamily 1, group D, member 2	436	0.77
chr5_75377548_75377800	0.09	Gm22084	predicted gene, 22084	5529	0.2
chr17_74528690_74528846	0.09	Birc6	baculoviral IAP repeat-containing 6	216	0.82
chr9_20607564_20607721	0.09	Gm48069	predicted gene, 48069	26	0.49
chr6_113469767_113469928	0.09	Il17rc	interleukin 17 receptor C	1580	0.17
chr4_43046114_43046311	0.09	Fam214b	family with sequence similarity 214, member B	8	0.67
chr14_65358460_65358659	0.09	Zfp395	zinc finger protein 395	25	0.95
chr13_30973965_30974242	0.09	Exoc2	exocyst complex component 2	10	0.53
chr9_64041799_64041950	0.09	1700055C04Rik	RIKEN cDNA 1700055C04 gene	409	0.78
chr11_98709546_98709720	0.09	Med24	mediator complex subunit 24	1433	0.2
chr7_128010040_128010379	0.09	Gm19366	predicted gene, 19366	2975	0.09
chr14_20083085_20083240	0.09	Saysd1	SAYSVFN motif domain containing 1	21	0.98
chr10_125725411_125725590	0.09	Gm9102	predicted gene 9102	212969	0.02
chr10_121626467_121626639	0.09	Xpot	exportin, tRNA (nuclear export receptor for tRNAs)	221	0.91
chr11_102138520_102138679	0.09	Nags	N-acetylglutamate synthase	6914	0.08
chr15_99126067_99126238	0.09	Spats2	spermatogenesis associated, serine-rich 2	231	0.86
chr5_35583017_35583168	0.09	Acox3	acyl-Coenzyme A oxidase 3, pristanoyl	0	0.97
chr18_34954283_34954445	0.08	Hspa9	heat shock protein 9	7	0.96
chr11_45008209_45008377	0.08	Ebf1	early B cell factor 1	96155	0.08
chr7_99182977_99183283	0.08	Dgat2	diacylglycerol O-acyltransferase 2	411	0.78
chr11_50025101_50025299	0.08	Rnf130	ring finger protein 130	146	0.96
chr13_95525061_95525230	0.08	F2rl1	coagulation factor II (thrombin) receptor-like 1	82	0.96
chr12_102705049_102705200	0.08	Itpk1	inositol 1,3,4-triphosphate 5/6 kinase	194	0.89
chr4_119108410_119108841	0.08	Slc2a1	solute carrier family 2 (facilitated glucose transporter), member 1	86	0.94
chr3_127124044_127124345	0.08	Ank2	ankyrin 2, brain	668	0.65
chr11_121259763_121259955	0.08	Foxk2	forkhead box K2	131	0.94
chr1_180179778_180180226	0.08	Coq8a	coenzyme Q8A	1080	0.44
chr11_82908100_82908264	0.08	Nle1	notchless homolog 1	160	0.89
chr11_101507204_101507377	0.08	Brca1	breast cancer 1, early onset	888	0.38
chr17_47864605_47864762	0.08	Foxp4	forkhead box P4	14270	0.12
chr5_64092821_64092990	0.08	Pgm2	phosphoglucomutase 2	45	0.96
chr7_105736434_105736596	0.08	Ilk	integrin linked kinase	77	0.58
chr5_129725307_129725503	0.08	Nipsnap2	nipsnap homolog 2	304	0.8
chr10_82868804_82868994	0.08	Eid3	EP300 interacting inhibitor of differentiation 3	2273	0.21
chr17_80728037_80728199	0.08	Gm9959	predicted gene 9959	13	0.5
chr19_8880846_8881009	0.08	Uqcc3	ubiquinol-cytochrome c reductase complex assembly factor 3	4	0.9
chr13_48968536_48968687	0.08	Fam120a	family with sequence similarity 120, member A	594	0.8
chr11_120549471_120549635	0.08	Mcrip1	MAPK regulated corepressor interacting protein 1	148	0.85
chr19_6057770_6057938	0.08	Fau	Finkel-Biskis-Reilly murine sarcoma virus (FBR-MuSV) ubiquitously expressed (fox derived)	10	0.52
chr17_66123664_66123841	0.08	Ddx11	DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11	139	0.93
chr9_70503778_70503941	0.08	Rnf111	ring finger 111	134	0.94
chr6_88841586_88841956	0.08	Abtb1	ankyrin repeat and BTB (POZ) domain containing 1	59	0.93
chr7_45000808_45000995	0.08	Irf3	interferon regulatory factor 3	153	0.84
chr8_124344380_124344599	0.07	Gm15775	predicted gene 15775	12694	0.14
chr8_123948951_123949132	0.07	Nup133	nucleoporin 133	214	0.52
chr3_49756473_49756624	0.07	Pcdh18	protocadherin 18	735	0.7
chr3_27710416_27710593	0.07	Fndc3b	fibronectin type III domain containing 3B	65	0.98
chr11_57801415_57801582	0.07	2010001A14Rik	RIKEN cDNA 2010001A14 gene	81	0.58
chr8_10899998_10900419	0.07	4833411C07Rik	RIKEN cDNA 4833411C07 gene	271	0.54

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hif1a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.2	GO:0061341	non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1	0.3	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.1	0.3	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.4	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
0.1	0.2	GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.1	0.2	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.1	0.2	GO:0042360	vitamin E metabolic process(GO:0042360)
0.1	0.2	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.1	0.2	GO:0019249	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.1	0.2	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.1	0.2	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
0.0	0.1	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.1	GO:0006285	base-excision repair, AP site formation(GO:0006285)
0.0	0.1	GO:0045048	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0	0.1	GO:0042758	long-chain fatty acid catabolic process(GO:0042758)
0.0	0.1	GO:0035425	autocrine signaling(GO:0035425)
0.0	0.3	GO:0003056	regulation of vascular smooth muscle contraction(GO:0003056)
0.0	0.1	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.1	GO:0034214	protein hexamerization(GO:0034214)
0.0	0.1	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.2	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.0	0.1	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.1	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0	0.1	GO:0006382	adenosine to inosine editing(GO:0006382)
0.0	0.1	GO:1904192	cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.0	0.2	GO:0019673	GDP-mannose metabolic process(GO:0019673)
0.0	0.2	GO:0034551	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0	0.1	GO:0043309	regulation of eosinophil degranulation(GO:0043309)
0.0	0.1	GO:0090526	regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.0	0.2	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.0	0.1	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.0	0.1	GO:0036089	cleavage furrow formation(GO:0036089)
0.0	0.1	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.0	GO:0043308	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.0	0.1	GO:0019064	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0	0.1	GO:0033750	ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753)
0.0	0.1	GO:0051031	tRNA transport(GO:0051031)
0.0	0.4	GO:0018345	protein palmitoylation(GO:0018345)
0.0	0.1	GO:2001199	negative regulation of dendritic cell differentiation(GO:2001199)
0.0	0.1	GO:0051697	protein delipidation(GO:0051697)
0.0	0.1	GO:1905154	negative regulation of membrane invagination(GO:1905154)
0.0	0.0	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.0	0.1	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.0	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.1	GO:0043622	cortical microtubule organization(GO:0043622)
0.0	0.1	GO:0060480	lung goblet cell differentiation(GO:0060480)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0	0.2	GO:0034389	lipid particle organization(GO:0034389)
0.0	0.0	GO:0042891	antibiotic transport(GO:0042891)
0.0	0.0	GO:0032264	IMP salvage(GO:0032264)
0.0	0.1	GO:0098910	regulation of atrial cardiac muscle cell action potential(GO:0098910)
0.0	0.1	GO:0035356	cellular triglyceride homeostasis(GO:0035356)
0.0	0.1	GO:0030035	microspike assembly(GO:0030035)
0.0	0.0	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.0	GO:0071336	regulation of hair follicle cell proliferation(GO:0071336)
0.0	0.1	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.0	GO:0001927	exocyst assembly(GO:0001927)
0.0	0.1	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.0	0.1	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.0	0.1	GO:0000463	maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.0	0.0	GO:1900738	positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.0	0.1	GO:0060510	Type II pneumocyte differentiation(GO:0060510)
0.0	0.0	GO:0001983	baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0	0.1	GO:0035518	histone H2A monoubiquitination(GO:0035518)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.0	GO:0051572	negative regulation of histone H3-K4 methylation(GO:0051572)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.2	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.1	0.2	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.1	0.2	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.1	GO:0071818	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0030689	Noc complex(GO:0030689)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.4	GO:0032433	filopodium tip(GO:0032433)
0.0	0.1	GO:0044308	axonal spine(GO:0044308)
0.0	0.1	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0008622	epsilon DNA polymerase complex(GO:0008622)
0.0	0.2	GO:0031616	spindle pole centrosome(GO:0031616)
0.0	0.1	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.2	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	0.2	GO:0032279	asymmetric synapse(GO:0032279)
0.0	0.0	GO:0048787	presynaptic active zone membrane(GO:0048787)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.0	GO:0000322	storage vacuole(GO:0000322)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.0	GO:0000811	GINS complex(GO:0000811)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.6	GO:0005811	lipid particle(GO:0005811)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0048408	epidermal growth factor binding(GO:0048408)
0.1	0.2	GO:0051434	BH3 domain binding(GO:0051434)
0.1	0.2	GO:0016018	cyclosporin A binding(GO:0016018)
0.1	0.2	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.1	0.2	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0	0.2	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0	0.1	GO:0070905	serine binding(GO:0070905)
0.0	0.6	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.1	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.2	GO:0016907	G-protein coupled acetylcholine receptor activity(GO:0016907)
0.0	0.1	GO:0016262	protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.0	0.1	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	0.2	GO:0018643	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:1901612	cardiolipin binding(GO:1901612)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.1	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.2	GO:0038191	neuropilin binding(GO:0038191)
0.0	0.1	GO:0030144	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.1	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.4	GO:0019706	protein-cysteine S-palmitoyltransferase activity(GO:0019706)
0.0	0.1	GO:0032454	histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.2	GO:0050811	GABA receptor binding(GO:0050811)
0.0	0.0	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.2	GO:0032183	SUMO binding(GO:0032183)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.0	GO:0042895	antibiotic transporter activity(GO:0042895)
0.0	0.0	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.0	GO:0016649	electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0	0.2	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.2	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.0	GO:0052833	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.3	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.2	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events
0.2	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.4	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.3	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.1	REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1	Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.0	0.0	REACTOME SOS MEDIATED SIGNALLING	Genes involved in SOS-mediated signalling
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.1	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.0	0.2	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.0	0.1	REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS	Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0	0.3	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.0	0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins