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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hivep1

Z-value: 1.68

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Transcription factors associated with Hivep1

Gene Symbol	Gene ID	Gene Info
Hivep1 Ensembl NCBI MGI UniProt	ENSMUSG00000021366.7	Hivep1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hivep1	chr13_42052837_42053016	522	0.803363	0.92	9.0e-03	Click!
Hivep1	chr13_42051493_42051760	395	0.853693	0.80	5.5e-02	Click!
Hivep1	chr13_42062809_42062993	10497	0.219785	0.75	8.4e-02	Click!
Hivep1	chr13_42053164_42053359	857	0.639304	-0.75	8.9e-02	Click!
Hivep1	chr13_42051976_42052134	34	0.978295	0.74	9.1e-02	Click!

Activity of the Hivep1 motif across conditions

Conditions sorted by the z-value of the Hivep1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_141628129_141628296	1.33	Mir7063	microRNA 7063	7511	0.13
chr6_72606152_72606303	0.87	Retsat	retinol saturase (all trans retinol 13,14 reductase)	255	0.72
chr1_127014601_127014752	0.85	Gm5261	predicted gene 5261	36020	0.21
chr12_98901637_98901855	0.79	Eml5	echinoderm microtubule associated protein like 5	262	0.91
chr9_50887504_50887656	0.79	Gm25558	predicted gene, 25558	370	0.85
chr5_8964466_8964675	0.76	Abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	6018	0.13
chr4_155245715_155246079	0.71	Faap20	Fanconi anemia core complex associated protein 20	3905	0.19
chr19_5430069_5430231	0.68	AI837181	expressed sequence AI837181	4993	0.05
chr18_65099329_65099521	0.67	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	16371	0.23
chr6_120540294_120540445	0.64	Hdhd5	haloacid dehalogenase like hydrolase domain containing 5	9050	0.12
chr2_156451427_156451737	0.62	Gm14225	predicted gene 14225	3974	0.13
chr2_135692897_135693099	0.61	Gm14211	predicted gene 14211	156	0.96
chr11_106528533_106528684	0.60	Gm22711	predicted gene, 22711	27363	0.13
chr10_24103718_24103905	0.56	Taar8c	trace amine-associated receptor 8C	1899	0.18
chr17_30590513_30590860	0.55	Gm50244	predicted gene, 50244	822	0.45
chr12_21160412_21160576	0.55	Asap2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	48540	0.12
chr13_69583732_69583897	0.54	Srd5a1	steroid 5 alpha-reductase 1	11015	0.12
chr2_158302944_158303106	0.54	Lbp	lipopolysaccharide binding protein	3468	0.15
chr10_24074506_24074765	0.52	Taar8a	trace amine-associated receptor 8A	1865	0.16
chr19_42612808_42613017	0.52	Loxl4	lysyl oxidase-like 4	99	0.97
chr2_32607757_32607919	0.52	St6galnac6	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	233	0.82
chr19_23035930_23036081	0.51	Gm50136	predicted gene, 50136	25449	0.19
chr5_105830258_105830416	0.49	Lrrc8d	leucine rich repeat containing 8D	5826	0.14
chr9_5308705_5308876	0.49	Casp4	caspase 4, apoptosis-related cysteine peptidase	38	0.98
chr11_79673804_79673986	0.48	Rab11fip4os2	RAB11 family interacting protein 4 (class II), opposite strand 2	1188	0.34
chr19_10690326_10690666	0.48	Vps37c	vacuolar protein sorting 37C	1731	0.21
chr1_93145749_93145928	0.47	Agxt	alanine-glyoxylate aminotransferase	5959	0.13
chr6_5496841_5497314	0.47	Pdk4	pyruvate dehydrogenase kinase, isoenzyme 4	768	0.76
chr10_24097357_24097545	0.47	Taar8c	trace amine-associated receptor 8C	4461	0.1
chr7_68709256_68709407	0.47	Gm44692	predicted gene 44692	17136	0.21
chr13_47150132_47150307	0.46	A930002C04Rik	RIKEN cDNA A930002C04 gene	1549	0.3
chr4_137497524_137497692	0.46	Hspg2	perlecan (heparan sulfate proteoglycan 2)	24851	0.12
chr11_95350469_95350629	0.46	Fam117a	family with sequence similarity 117, member A	10587	0.12
chr13_41334685_41334849	0.46	Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	24480	0.12
chr10_94072375_94072538	0.45	Fgd6	FYVE, RhoGEF and PH domain containing 6	86	0.96
chr8_70564788_70565043	0.45	Ell	elongation factor RNA polymerase II	25227	0.07
chr11_94346567_94346751	0.45	Abcc3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	4527	0.17
chr8_33902604_33902775	0.45	Rbpms	RNA binding protein gene with multiple splicing	10925	0.17
chr10_59786230_59786381	0.45	Gm17059	predicted gene 17059	13949	0.14
chr9_73105883_73106055	0.44	Khdc3	KH domain containing 3, subcortical maternal complex member	3459	0.12
chr5_146687074_146687253	0.44	4930573C15Rik	RIKEN cDNA 4930573C15 gene	19459	0.16
chr1_36064998_36065160	0.44	Hs6st1	heparan sulfate 6-O-sulfotransferase 1	3321	0.19
chr8_105820252_105820414	0.43	Ranbp10	RAN binding protein 10	6872	0.09
chr12_55492611_55492778	0.43	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	47	0.97
chr4_60659551_60660018	0.43	Mup11	major urinary protein 11	46	0.97
chr18_39693461_39693788	0.43	Gm50398	predicted gene, 50398	32747	0.16
chr10_23842034_23842208	0.42	Vnn3	vanin 3	9341	0.12
chr4_44990961_44991112	0.42	Grhpr	glyoxylate reductase/hydroxypyruvate reductase	9536	0.11
chr2_43548371_43548543	0.42	Kynu	kynureninase	6872	0.28
chr10_59403529_59403689	0.41	Pla2g12b	phospholipase A2, group XIIB	51	0.97
chr8_119423599_119423760	0.41	Osgin1	oxidative stress induced growth inhibitor 1	10445	0.15
chr8_75092030_75092181	0.41	Hmox1	heme oxygenase 1	1516	0.3
chr9_64506948_64507234	0.41	Megf11	multiple EGF-like-domains 11	5490	0.28
chr7_74647398_74647580	0.41	Gm7726	predicted gene 7726	52367	0.15
chr8_106500079_106500253	0.41	6030452D12Rik	RIKEN cDNA 6030452D12 gene	339	0.87
chr8_124634513_124634671	0.41	Capn9	calpain 9	21152	0.14
chr1_180163928_180164201	0.40	Cdc42bpa	CDC42 binding protein kinase alpha	3057	0.2
chr19_18627525_18627688	0.40	Ostf1	osteoclast stimulating factor 1	4112	0.19
chr16_30163409_30163569	0.39	n-R5s32	nuclear encoded rRNA 5S 32	21544	0.12
chr3_36551644_36551818	0.39	Exosc9	exosome component 9	875	0.45
chr1_165486032_165486258	0.39	Adcy10	adenylate cyclase 10	934	0.38
chr13_69264071_69264248	0.39	Gm4812	predicted gene 4812	81496	0.09
chr11_75231643_75231820	0.39	Rtn4rl1	reticulon 4 receptor-like 1	37948	0.08
chr6_71204222_71204852	0.39	Fabp1	fatty acid binding protein 1, liver	4710	0.14
chr18_36703302_36703470	0.39	E230025N22Rik	Riken cDNA E230025N22 gene	7461	0.08
chr4_106845457_106845733	0.39	Gm12746	predicted gene 12746	2325	0.28
chr6_48700323_48700513	0.38	Gimap6	GTPase, IMAP family member 6	5818	0.08
chr3_105803714_105803865	0.38	Rap1a	RAS-related protein 1a	2453	0.17
chr7_143792435_143792623	0.38	Nadsyn1	NAD synthetase 1	6312	0.11
chr12_104262958_104263126	0.38	Serpina3i	serine (or cysteine) peptidase inhibitor, clade A, member 3I	80	0.94
chr11_16919693_16920246	0.37	Egfr	epidermal growth factor receptor	14784	0.17
chr13_98595769_98595925	0.37	Gm4815	predicted gene 4815	17654	0.12
chr12_105046297_105046454	0.37	Glrx5	glutaredoxin 5	11159	0.1
chr5_118294350_118294584	0.37	Gm25076	predicted gene, 25076	28018	0.15
chr19_47330818_47330996	0.37	Sh3pxd2a	SH3 and PX domains 2A	16156	0.18
chr12_29137061_29137232	0.37	Gm31333	predicted gene, 31333	2021	0.39
chr7_44861566_44861717	0.36	Pnkp	polynucleotide kinase 3'- phosphatase	56	0.92
chr14_46261947_46262118	0.36	Gm15217	predicted gene 15217	117382	0.05
chr1_165849593_165849764	0.36	Gm37469	predicted gene, 37469	634	0.54
chr9_20781366_20781683	0.35	Col5a3	collagen, type V, alpha 3	33543	0.09
chr15_97184306_97184490	0.35	Gm32885	predicted gene, 32885	17154	0.22
chr2_128738093_128738244	0.35	Gm14011	predicted gene 14011	15537	0.15
chr15_79234881_79235032	0.35	Pick1	protein interacting with C kinase 1	5254	0.1
chr8_123777594_123777758	0.35	Gm45865	predicted gene 45865	10125	0.08
chr14_25710571_25710770	0.35	1700054O19Rik	RIKEN cDNA 1700054O19 gene	3397	0.17
chr9_20804931_20805096	0.35	Col5a3	collagen, type V, alpha 3	10054	0.11
chr4_41555100_41555359	0.35	Fam219a	family with sequence similarity 219, member A	14280	0.1
chr17_29395434_29395615	0.35	Fgd2	FYVE, RhoGEF and PH domain containing 2	19023	0.11
chr5_112486568_112486719	0.35	Sez6l	seizure related 6 homolog like	11516	0.16
chr15_25914259_25914426	0.34	Retreg1	reticulophagy regulator 1	3918	0.25
chr10_19942019_19942177	0.34	Map3k5	mitogen-activated protein kinase kinase kinase 5	6875	0.22
chr15_78995837_78995995	0.34	Triobp	TRIO and F-actin binding protein	6066	0.08
chr13_111809911_111810122	0.33	Gm15327	predicted gene 15327	452	0.67
chr2_25095384_25095554	0.33	Noxa1	NADPH oxidase activator 1	320	0.75
chr2_50964157_50964313	0.33	Gm13498	predicted gene 13498	54551	0.16
chr11_78697500_78697668	0.33	Nlk	nemo like kinase	211	0.92
chr13_43236729_43237131	0.32	Tbc1d7	TBC1 domain family, member 7	65429	0.1
chr13_113530199_113530540	0.32	4921509O07Rik	RIKEN cDNA 4921509O07 gene	27525	0.13
chr9_47254607_47254758	0.32	Gm31816	predicted gene, 31816	16061	0.23
chr1_88976364_88976553	0.32	1700067G17Rik	RIKEN cDNA 1700067G17 gene	39655	0.14
chr15_82147771_82148080	0.32	Srebf2	sterol regulatory element binding factor 2	88	0.94
chr4_60419310_60419496	0.32	Mup9	major urinary protein 9	1181	0.4
chr16_48767631_48767807	0.31	Trat1	T cell receptor associated transmembrane adaptor 1	4237	0.22
chr6_88737071_88737256	0.31	Gm44005	predicted gene, 44005	1029	0.4
chr6_125361870_125362038	0.31	Tnfrsf1a	tumor necrosis factor receptor superfamily, member 1a	1527	0.28
chr5_89033271_89033463	0.31	Slc4a4	solute carrier family 4 (anion exchanger), member 4	5275	0.32
chr11_87025481_87025638	0.31	Gm22387	predicted gene, 22387	28296	0.11
chr8_13670213_13670364	0.31	Rasa3	RAS p21 protein activator 3	7163	0.18
chr2_52918246_52918431	0.31	Fmnl2	formin-like 2	60470	0.14
chr1_90909242_90909420	0.31	Mlph	melanophilin	5754	0.17
chr3_65958418_65958847	0.31	Ccnl1	cyclin L1	383	0.66
chr14_47057457_47057608	0.30	Samd4	sterile alpha motif domain containing 4	11442	0.16
chr2_181677237_181677441	0.30	Tcea2	transcription elongation factor A (SII), 2	2971	0.12
chr19_26733384_26733559	0.30	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	3472	0.3
chr12_28898892_28899474	0.30	Gm31508	predicted gene, 31508	11046	0.17
chr12_110219862_110220027	0.30	Gm40576	predicted gene, 40576	16418	0.11
chr13_42052837_42053016	0.30	Hivep1	human immunodeficiency virus type I enhancer binding protein 1	522	0.8
chr2_25534308_25534469	0.30	Traf2	TNF receptor-associated factor 2	4752	0.08
chr14_117648617_117648937	0.30	Mir6239	microRNA 6239	305070	0.01
chr15_82390095_82390257	0.30	Mir7684	microRNA 7684	3802	0.07
chr8_45267218_45267382	0.30	F11	coagulation factor XI	5269	0.18
chr16_4029500_4029663	0.30	Dnase1	deoxyribonuclease I	7361	0.1
chr3_97620588_97620739	0.30	Fmo5	flavin containing monooxygenase 5	8141	0.14
chr9_35318763_35318962	0.29	Gm33838	predicted gene, 33838	11263	0.13
chr6_116654223_116654391	0.29	Depp1	DEPP1 autophagy regulator	3611	0.13
chr8_84660024_84660186	0.29	Ier2	immediate early response 2	2749	0.14
chr11_7198962_7199113	0.29	Igfbp1	insulin-like growth factor binding protein 1	1255	0.43
chr16_35363303_35363500	0.29	Sec22a	SEC22 homolog A, vesicle trafficking protein	414	0.79
chr10_81430090_81430281	0.29	Nfic	nuclear factor I/C	820	0.33
chr8_117368850_117369012	0.29	Cmip	c-Maf inducing protein	19761	0.22
chr11_82016294_82016449	0.29	Gm31522	predicted gene, 31522	3596	0.16
chr10_80764726_80764877	0.29	Gm17151	predicted gene 17151	4186	0.1
chr6_119402004_119402155	0.29	Adipor2	adiponectin receptor 2	11831	0.2
chr13_93989307_93989458	0.29	Gm47216	predicted gene, 47216	2386	0.28
chr6_119902151_119902479	0.29	4930540M05Rik	RIKEN cDNA 4930540M05 gene	338	0.51
chr3_83029428_83029640	0.29	Fga	fibrinogen alpha chain	3319	0.18
chr19_46133855_46134398	0.28	Elovl3	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	2229	0.19
chr19_57553071_57553238	0.28	Gm50285	predicted gene, 50285	8931	0.15
chr11_49088297_49088883	0.28	Gm12188	predicted gene 12188	47	0.79
chr19_46137654_46137874	0.28	Pitx3	paired-like homeodomain transcription factor 3	475	0.71
chr4_61779591_61780024	0.28	Mup19	major urinary protein 19	2417	0.19
chr10_127067027_127067252	0.28	Cdk4	cyclin-dependent kinase 4	1063	0.24
chr5_53042406_53042593	0.28	Slc34a2	solute carrier family 34 (sodium phosphate), member 2	4418	0.19
chr2_85107051_85107210	0.28	4930443O20Rik	RIKEN cDNA 4930443O20 gene	20669	0.11
chr13_112192610_112192944	0.27	Gm48802	predicted gene, 48802	20709	0.16
chr17_46674852_46675062	0.27	Rrp36	ribosomal RNA processing 36 homolog (S. cerevisiae)	605	0.51
chr14_76179509_76179660	0.27	Rps2-ps6	ribosomal protein S2, pseudogene 6	57961	0.11
chr11_4974491_4974717	0.27	Ap1b1	adaptor protein complex AP-1, beta 1 subunit	12220	0.13
chr4_136174341_136174511	0.27	E2f2	E2F transcription factor 2	2032	0.24
chr7_115564788_115564958	0.27	Sox6	SRY (sex determining region Y)-box 6	33023	0.24
chr9_108083627_108083864	0.26	Rnf123	ring finger protein 123	399	0.46
chr19_42780063_42780262	0.26	Hps1	HPS1, biogenesis of lysosomal organelles complex 3 subunit 1	184	0.9
chr5_89355824_89355979	0.26	Gc	vitamin D binding protein	79727	0.11
chr4_61301111_61301509	0.26	Mup14	major urinary protein 14	2055	0.32
chr2_52930153_52930305	0.26	Fmnl2	formin-like 2	72361	0.12
chr6_125575019_125575372	0.26	Vwf	Von Willebrand factor	8944	0.21
chr5_151345483_151345662	0.26	1700028E10Rik	RIKEN cDNA 1700028E10 gene	23103	0.16
chr10_84886268_84886436	0.26	Ric8b	RIC8 guanine nucleotide exchange factor B	31264	0.17
chr14_60414955_60415106	0.26	Gm6066	predicted gene 6066	26949	0.17
chr16_91355282_91355468	0.26	Gm24695	predicted gene, 24695	5591	0.13
chr1_40680680_40680831	0.26	Slc9a2	solute carrier family 9 (sodium/hydrogen exchanger), member 2	181	0.95
chr7_19817545_19817767	0.26	Gm16174	predicted gene 16174	1103	0.24
chr2_32875662_32875824	0.25	Gm13523	predicted gene 13523	258	0.58
chr1_72832378_72832635	0.25	Igfbp2	insulin-like growth factor binding protein 2	7184	0.23
chr4_120283294_120283461	0.25	Foxo6	forkhead box O6	3972	0.25
chr11_114867640_114867800	0.25	Gprc5c	G protein-coupled receptor, family C, group 5, member C	3228	0.17
chr12_85698292_85698454	0.25	Batf	basic leucine zipper transcription factor, ATF-like	9081	0.13
chr8_106138653_106138804	0.25	1810019D21Rik	RIKEN cDNA 1810019D21 gene	1663	0.21
chr4_20017927_20018324	0.25	Ttpa	tocopherol (alpha) transfer protein	9697	0.19
chr7_101302097_101302264	0.25	Atg16l2	autophagy related 16-like 2 (S. cerevisiae)	71	0.95
chr9_66620785_66620957	0.25	Usp3	ubiquitin specific peptidase 3	27729	0.17
chr4_43492855_43493028	0.25	Ccdc107	coiled-coil domain containing 107	41	0.58
chr12_102453853_102454036	0.25	Gm30198	predicted gene, 30198	6616	0.17
chr2_116990270_116990421	0.25	Gm29340	predicted gene 29340	13917	0.19
chr2_167853451_167853633	0.25	Gm14319	predicted gene 14319	5043	0.19
chr2_133427180_133427333	0.25	A430048G15Rik	RIKEN cDNA A430048G15 gene	4839	0.26
chr2_38378853_38379004	0.24	Gm13584	predicted gene 13584	14948	0.14
chr18_16213890_16214071	0.24	Gm7665	predicted pseudogene 7665	60964	0.14
chr5_35755279_35755445	0.24	Ablim2	actin-binding LIM protein 2	2518	0.26
chr4_61436878_61437320	0.24	Mup15	major urinary protein 15	2644	0.27
chr10_60280489_60280673	0.24	Psap	prosaposin	2953	0.25
chr11_102409825_102409994	0.24	Slc25a39	solute carrier family 25, member 39	1963	0.17
chr11_97920869_97921025	0.24	Gm22461	predicted gene, 22461	20793	0.1
chr7_141335382_141335533	0.24	Tmem80	transmembrane protein 80	1799	0.16
chr19_36627002_36627176	0.24	Hectd2os	Hectd2, opposite strand	1065	0.57
chr2_119546518_119546691	0.24	Exd1	exonuclease 3'-5' domain containing 1	590	0.55
chr6_94169886_94170336	0.24	Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	112914	0.06
chr12_26356269_26356452	0.23	4930549C15Rik	RIKEN cDNA 4930549C15 gene	9643	0.19
chr8_75385238_75385564	0.23	Umpk-ps	uridine monophosphate kinase, pseudogene	1599	0.31
chr10_93493384_93493577	0.23	Hal	histidine ammonia lyase	2925	0.2
chr1_131473746_131474085	0.23	Gm24273	predicted gene, 24273	24887	0.12
chr16_35742175_35742539	0.23	Gm25967	predicted gene, 25967	20124	0.13
chr18_46718542_46718894	0.23	Cdo1	cysteine dioxygenase 1, cytosolic	9311	0.13
chr4_133084344_133084978	0.23	Ahdc1	AT hook, DNA binding motif, containing 1	18412	0.17
chr19_5810333_5810765	0.23	Malat1	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	7877	0.08
chr4_40239674_40239847	0.23	Ddx58	DEAD (Asp-Glu-Ala-Asp) box polypeptide 58	5	0.97
chr17_24204987_24205163	0.23	Tbc1d24	TBC1 domain family, member 24	407	0.66
chr10_67288327_67288543	0.23	Nrbf2	nuclear receptor binding factor 2	3130	0.22
chrX_20862192_20862360	0.23	Mir5617	microRNA 5617	906	0.41
chr18_4964609_4964760	0.23	Svil	supervillin	29129	0.24

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hivep1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.1	0.4	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.1	0.3	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.1	0.3	GO:0052173	response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
0.1	0.3	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	0.1	GO:0032079	positive regulation of endodeoxyribonuclease activity(GO:0032079)
0.1	0.2	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.1	0.3	GO:0060486	Clara cell differentiation(GO:0060486)
0.1	0.1	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1	0.2	GO:0045472	response to ether(GO:0045472)
0.1	0.2	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.1	0.3	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.1	0.2	GO:0034473	U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476)
0.1	0.5	GO:0035234	ectopic germ cell programmed cell death(GO:0035234)
0.1	0.3	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.1	0.2	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.1	0.2	GO:0009597	detection of virus(GO:0009597)
0.1	0.1	GO:1904179	positive regulation of adipose tissue development(GO:1904179)
0.0	0.1	GO:2000313	fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.0	0.5	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.2	GO:0060264	regulation of respiratory burst involved in inflammatory response(GO:0060264)
0.0	0.1	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.2	GO:0044034	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.1	GO:0010916	regulation of very-low-density lipoprotein particle clearance(GO:0010915) negative regulation of very-low-density lipoprotein particle clearance(GO:0010916)
0.0	0.2	GO:0070842	aggresome assembly(GO:0070842)
0.0	0.2	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.3	GO:0033136	serine phosphorylation of STAT3 protein(GO:0033136)
0.0	0.1	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.0	0.1	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.2	GO:1901896	positive regulation of calcium-transporting ATPase activity(GO:1901896)
0.0	0.1	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.1	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.2	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237)
0.0	0.2	GO:0007220	Notch receptor processing(GO:0007220)
0.0	0.2	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.6	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.1	GO:2001171	positive regulation of ATP biosynthetic process(GO:2001171)
0.0	0.1	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.0	GO:0045002	double-strand break repair via single-strand annealing(GO:0045002)
0.0	0.1	GO:0001887	selenium compound metabolic process(GO:0001887)
0.0	0.1	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0	0.1	GO:0035880	embryonic nail plate morphogenesis(GO:0035880)
0.0	0.2	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.1	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.0	0.2	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:2000553	positive regulation of T-helper 2 cell cytokine production(GO:2000553)
0.0	0.1	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.1	GO:0035425	autocrine signaling(GO:0035425)
0.0	0.0	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.0	0.3	GO:0042511	positive regulation of tyrosine phosphorylation of Stat1 protein(GO:0042511)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.2	GO:0099515	actin filament-based transport(GO:0099515)
0.0	0.1	GO:1990314	cellular response to insulin-like growth factor stimulus(GO:1990314)
0.0	0.2	GO:1901409	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.2	GO:0060708	spongiotrophoblast differentiation(GO:0060708)
0.0	0.1	GO:0035790	platelet-derived growth factor receptor-alpha signaling pathway(GO:0035790)
0.0	0.1	GO:0045950	negative regulation of mitotic recombination(GO:0045950)
0.0	0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.4	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0	0.1	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.2	GO:0060263	regulation of respiratory burst(GO:0060263)
0.0	0.1	GO:0010626	negative regulation of Schwann cell proliferation(GO:0010626)
0.0	0.1	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.1	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.2	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.1	GO:0006566	threonine metabolic process(GO:0006566)
0.0	0.1	GO:0043133	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.1	GO:0036394	amylase secretion(GO:0036394)
0.0	0.1	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.0	0.2	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.0	GO:0048320	axial mesoderm formation(GO:0048320)
0.0	0.1	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.2	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.0	0.0	GO:0003162	atrioventricular node development(GO:0003162)
0.0	0.1	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.1	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.0	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.1	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.2	GO:2001223	negative regulation of neuron migration(GO:2001223)
0.0	0.0	GO:0071725	response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.2	GO:0098719	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0	0.1	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.1	GO:0038171	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.1	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0	0.1	GO:0070948	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.1	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.0	0.1	GO:0032417	positive regulation of sodium:proton antiporter activity(GO:0032417)
0.0	0.1	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:0071830	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.1	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.1	GO:0033504	floor plate development(GO:0033504)
0.0	0.0	GO:0045054	constitutive secretory pathway(GO:0045054)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.2	GO:0030277	maintenance of gastrointestinal epithelium(GO:0030277)
0.0	0.0	GO:1901679	nucleotide transmembrane transport(GO:1901679)
0.0	0.1	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0	0.1	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.4	GO:0055090	acylglycerol homeostasis(GO:0055090) triglyceride homeostasis(GO:0070328)
0.0	0.1	GO:0003072	regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
0.0	0.1	GO:0000820	regulation of glutamine family amino acid metabolic process(GO:0000820)
0.0	0.1	GO:0002726	positive regulation of T cell cytokine production(GO:0002726)
0.0	0.1	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0001828	inner cell mass cellular morphogenesis(GO:0001828)
0.0	0.3	GO:0000301	retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.0	0.1	GO:0030576	Cajal body organization(GO:0030576)
0.0	0.1	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.1	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.1	GO:0034162	toll-like receptor 9 signaling pathway(GO:0034162)
0.0	0.0	GO:0015879	carnitine transport(GO:0015879)
0.0	0.1	GO:0010288	response to lead ion(GO:0010288)
0.0	0.2	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0	0.0	GO:0000189	MAPK import into nucleus(GO:0000189)
0.0	0.0	GO:0003130	BMP signaling pathway involved in heart induction(GO:0003130) endodermal-mesodermal cell signaling(GO:0003133) endodermal-mesodermal cell signaling involved in heart induction(GO:0003134)
0.0	0.1	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.0	0.1	GO:1900025	negative regulation of substrate adhesion-dependent cell spreading(GO:1900025)
0.0	0.1	GO:0034116	positive regulation of heterotypic cell-cell adhesion(GO:0034116)
0.0	0.1	GO:0032075	positive regulation of nuclease activity(GO:0032075)
0.0	0.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.0	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.0	0.0	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0	0.0	GO:0035963	response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.0	0.0	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.0	GO:0006114	glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
0.0	0.1	GO:1904415	regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.0	0.1	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.1	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0	0.0	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.1	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	0.1	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.0	0.0	GO:0033091	positive regulation of immature T cell proliferation(GO:0033091)
0.0	0.2	GO:0019985	translesion synthesis(GO:0019985)
0.0	0.0	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.3	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.1	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.0	0.1	GO:0048318	axial mesoderm development(GO:0048318)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.0	GO:2000726	negative regulation of cardiac muscle cell differentiation(GO:2000726)
0.0	0.1	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.0	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.0	GO:0032202	telomere assembly(GO:0032202)
0.0	0.2	GO:0003351	epithelial cilium movement(GO:0003351)
0.0	0.0	GO:0034316	negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
0.0	0.1	GO:1902033	regulation of hematopoietic stem cell proliferation(GO:1902033)
0.0	0.1	GO:0044068	modulation by symbiont of host cellular process(GO:0044068)
0.0	0.1	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.0	0.0	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.0	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.0	GO:0060051	negative regulation of protein glycosylation(GO:0060051)
0.0	0.0	GO:0060956	endocardial cell differentiation(GO:0060956)
0.0	0.0	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.0	GO:0014045	establishment of endothelial blood-brain barrier(GO:0014045)
0.0	0.0	GO:0009756	carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255)
0.0	0.0	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.0	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.1	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.0	GO:0015846	polyamine transport(GO:0015846)
0.0	0.2	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.1	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.0	0.1	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0	0.0	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.0	GO:0097155	fasciculation of sensory neuron axon(GO:0097155)
0.0	0.0	GO:0043379	memory T cell differentiation(GO:0043379)
0.0	0.0	GO:0048254	snoRNA localization(GO:0048254)
0.0	0.0	GO:2000304	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0	0.0	GO:0033030	negative regulation of neutrophil apoptotic process(GO:0033030)
0.0	0.0	GO:0070343	white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.0	0.0	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.1	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0	0.0	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0071816	protein insertion into ER membrane(GO:0045048) tail-anchored membrane protein insertion into ER membrane(GO:0071816)
0.0	0.1	GO:1902036	regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0	0.0	GO:0035739	CD4-positive, alpha-beta T cell proliferation(GO:0035739)
0.0	0.0	GO:0023021	termination of signal transduction(GO:0023021)
0.0	0.0	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.0	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.1	GO:0045064	T-helper 2 cell differentiation(GO:0045064)
0.0	0.0	GO:0050904	diapedesis(GO:0050904)
0.0	0.0	GO:2000394	regulation of lamellipodium morphogenesis(GO:2000392) positive regulation of lamellipodium morphogenesis(GO:2000394)
0.0	0.0	GO:0070102	interleukin-6-mediated signaling pathway(GO:0070102)
0.0	0.0	GO:0045583	regulation of cytotoxic T cell differentiation(GO:0045583) positive regulation of cytotoxic T cell differentiation(GO:0045585)
0.0	0.1	GO:0072673	lamellipodium morphogenesis(GO:0072673)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.0	GO:0006069	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.0	GO:1902445	regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
0.0	0.0	GO:0086045	membrane depolarization during AV node cell action potential(GO:0086045)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0009437	carnitine metabolic process(GO:0009437)
0.0	0.1	GO:0006689	ganglioside catabolic process(GO:0006689)
0.0	0.0	GO:0032802	low-density lipoprotein particle receptor catabolic process(GO:0032802) regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.0	0.1	GO:0046322	negative regulation of fatty acid oxidation(GO:0046322)
0.0	0.3	GO:0006953	acute-phase response(GO:0006953)
0.0	0.1	GO:0019363	pyridine nucleotide biosynthetic process(GO:0019363)
0.0	0.0	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.0	GO:0002434	immune complex clearance(GO:0002434)
0.0	0.0	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.0	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.0	0.0	GO:0032792	negative regulation of CREB transcription factor activity(GO:0032792)
0.0	0.1	GO:0033601	positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0	0.1	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.0	0.2	GO:0045662	negative regulation of myoblast differentiation(GO:0045662)
0.0	0.0	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.0	0.0	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.1	GO:0061469	regulation of type B pancreatic cell proliferation(GO:0061469)
0.0	0.0	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0	0.0	GO:0006432	phenylalanyl-tRNA aminoacylation(GO:0006432)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0097169	AIM2 inflammasome complex(GO:0097169)
0.1	0.3	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.1	0.2	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.1	0.3	GO:1990246	uniplex complex(GO:1990246)
0.1	0.2	GO:0097451	glial limiting end-foot(GO:0097451)
0.1	0.8	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.1	GO:1990923	PET complex(GO:1990923)
0.0	0.1	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.2	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.2	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0008541	proteasome regulatory particle, lid subcomplex(GO:0008541)
0.0	0.1	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.3	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.2	GO:0043020	NADPH oxidase complex(GO:0043020)
0.0	0.1	GO:0098642	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.0	GO:0032010	phagolysosome(GO:0032010)
0.0	0.2	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.2	GO:0001650	fibrillar center(GO:0001650)
0.0	0.1	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.3	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0	0.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.3	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.3	GO:0000421	autophagosome membrane(GO:0000421)
0.0	0.3	GO:0031082	BLOC complex(GO:0031082)
0.0	0.0	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.2	GO:0005766	primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.0	0.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	0.1	GO:0044613	nuclear pore central transport channel(GO:0044613)
0.0	0.1	GO:0000778	condensed nuclear chromosome kinetochore(GO:0000778)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.2	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.2	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0005818	aster(GO:0005818)
0.0	0.0	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.0	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.1	GO:0000813	ESCRT I complex(GO:0000813)
0.0	0.1	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.2	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.1	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.0	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.0	GO:0044194	cytolytic granule(GO:0044194)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0035631	CD40 receptor complex(GO:0035631)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.3	GO:0000307	cyclin-dependent protein kinase holoenzyme complex(GO:0000307)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.1	0.3	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.1	0.4	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.1	0.3	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.1	0.3	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	0.4	GO:0070891	lipoteichoic acid binding(GO:0070891)
0.1	1.0	GO:0001594	trace-amine receptor activity(GO:0001594)
0.1	0.2	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.1	0.2	GO:0004967	glucagon receptor activity(GO:0004967)
0.1	0.2	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.2	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.3	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.1	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.1	GO:0043120	tumor necrosis factor binding(GO:0043120)
0.0	0.2	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.1	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.3	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.2	GO:0004854	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.0	0.2	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.0	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0043199	sulfate binding(GO:0043199)
0.0	0.1	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.1	GO:0004528	phosphodiesterase I activity(GO:0004528)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.2	GO:0031386	protein tag(GO:0031386)
0.0	0.2	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0047751	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0	0.0	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.1	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.1	GO:0070653	high-density lipoprotein particle receptor binding(GO:0070653)
0.0	0.1	GO:0015119	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.0	0.2	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.1	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.1	GO:0004345	glucose-6-phosphate dehydrogenase activity(GO:0004345)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	0.1	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.2	GO:0015386	sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0	0.2	GO:0004016	adenylate cyclase activity(GO:0004016)
0.0	0.1	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.1	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.1	GO:0070905	serine binding(GO:0070905)
0.0	0.1	GO:0015205	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.2	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.1	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	0.1	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.1	GO:0004127	cytidylate kinase activity(GO:0004127)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0048406	nerve growth factor binding(GO:0048406)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.0	GO:0005087	Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.3	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.0	GO:0070546	L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0018644	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.4	GO:0004623	phospholipase A2 activity(GO:0004623)
0.0	0.3	GO:0005035	tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.1	GO:0097157	pre-mRNA intronic binding(GO:0097157)
0.0	0.1	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.2	GO:0070628	proteasome binding(GO:0070628)
0.0	0.1	GO:0019869	chloride channel inhibitor activity(GO:0019869)
0.0	0.0	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.0	GO:0019961	interferon binding(GO:0019961)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.0	0.0	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.0	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.3	GO:0004707	MAP kinase activity(GO:0004707)
0.0	0.0	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.0	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:0034902	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.0	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.0	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.4	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	0.0	GO:0010858	calcium-dependent protein kinase regulator activity(GO:0010858)
0.0	0.0	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.0	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0	0.0	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0017127	cholesterol transporter activity(GO:0017127)
0.0	0.0	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.3	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.0	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0015106	bicarbonate transmembrane transporter activity(GO:0015106)
0.0	0.0	GO:0008271	secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0	0.2	GO:0017091	AU-rich element binding(GO:0017091)
0.0	0.4	GO:0031593	polyubiquitin binding(GO:0031593)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.9	PID CD40 PATHWAY	CD40/CD40L signaling
0.0	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.6	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.0	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.5	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.2	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.3	PID CERAMIDE PATHWAY	Ceramide signaling pathway
0.1	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.0	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.4	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	PID MET PATHWAY	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.4	NABA BASEMENT MEMBRANES	Genes encoding structural components of basement membranes
0.0	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.2	PID AURORA A PATHWAY	Aurora A signaling
0.3	PID IL6 7 PATHWAY	IL6-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.2	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.0	0.7	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.2	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.3	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.4	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.3	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.0	0.0	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.3	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.0	0.2	REACTOME MRNA DECAY BY 3 TO 5 EXORIBONUCLEASE	Genes involved in mRNA Decay by 3' to 5' Exoribonuclease
0.0	0.0	REACTOME GPCR DOWNSTREAM SIGNALING	Genes involved in GPCR downstream signaling
0.0	0.1	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.0	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.0	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.1	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.1	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.0	0.1	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.0	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.0	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.2	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.0	0.2	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.1	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0	0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.0	0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.1	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.0	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes