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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hoxa1

Z-value: 1.32

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Transcription factors associated with Hoxa1

Gene Symbol	Gene ID	Gene Info
Hoxa1 Ensembl NCBI MGI UniProt	ENSMUSG00000029844.9	Hoxa1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hoxa1	chr6_52158247_52158413	13	0.564831	-0.02	9.8e-01	Click!

Activity of the Hoxa1 motif across conditions

Conditions sorted by the z-value of the Hoxa1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr15_34500771_34501210	1.12	Pop1	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)	5667	0.12
chr11_75495112_75495263	0.85	Prpf8	pre-mRNA processing factor 8	2941	0.12
chr6_90509396_90509549	0.72	Gm44236	predicted gene, 44236	3830	0.15
chr11_43783562_43783743	0.70	Ttc1	tetratricopeptide repeat domain 1	35644	0.16
chr18_54249896_54250047	0.65	Redrum	Redrum, erythroid developmental long intergenic non-protein coding transcript	172324	0.03
chr7_28244671_28244868	0.60	Gm18672	predicted gene, 18672	8849	0.09
chr7_28243862_28244153	0.59	Gm18672	predicted gene, 18672	8087	0.09
chr13_93627456_93627944	0.57	Gm15622	predicted gene 15622	2318	0.25
chr1_79823871_79824030	0.54	Serpine2	serine (or cysteine) peptidase inhibitor, clade E, member 2	2628	0.28
chr19_40184875_40185171	0.53	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	2263	0.24
chr14_65097091_65097390	0.53	Extl3	exostosin-like glycosyltransferase 3	865	0.63
chr10_69208384_69208535	0.52	Rhobtb1	Rho-related BTB domain containing 1	93	0.97
chr5_74907535_74907686	0.52	Gm17906	predicted gene, 17906	24275	0.16
chr8_5106135_5106286	0.49	Slc10a2	solute carrier family 10, member 2	859	0.59
chr6_24610042_24610446	0.47	Lmod2	leiomodin 2 (cardiac)	12482	0.14
chr10_68107778_68107929	0.47	Arid5b	AT rich interactive domain 5B (MRF1-like)	28773	0.19
chr5_122455814_122455965	0.46	Anapc7	anaphase promoting complex subunit 7	14514	0.09
chr9_48738986_48739137	0.45	Zbtb16	zinc finger and BTB domain containing 16	96884	0.07
chr8_127515465_127515616	0.45	Gm6921	predicted pseudogene 6921	45895	0.17
chr4_107117393_107117544	0.44	Gm12802	predicted gene 12802	9145	0.13
chr5_66032675_66032852	0.44	Rbm47	RNA binding motif protein 47	21789	0.11
chr14_7870473_7870795	0.44	Flnb	filamin, beta	14107	0.18
chr3_52257597_52258053	0.44	Foxo1	forkhead box O1	10511	0.12
chr3_130038452_130038603	0.43	Sec24b	Sec24 related gene family, member B (S. cerevisiae)	2306	0.27
chr14_20185275_20185426	0.43	Kcnk5	potassium channel, subfamily K, member 5	3541	0.16
chr5_92469894_92470049	0.43	Mir6415	microRNA 6415	11414	0.14
chr10_77629279_77629435	0.43	Ube2g2	ubiquitin-conjugating enzyme E2G 2	6979	0.08
chr8_35387028_35387898	0.42	Ppp1r3b	protein phosphatase 1, regulatory subunit 3B	10803	0.16
chr7_139684055_139684211	0.42	Cfap46	cilia and flagella associated protein 46	316	0.88
chr6_111373388_111373549	0.41	Grm7	glutamate receptor, metabotropic 7	122247	0.06
chr10_68134623_68135230	0.39	Arid5b	AT rich interactive domain 5B (MRF1-like)	1700	0.47
chr18_44661527_44661720	0.39	A930012L18Rik	RIKEN cDNA A930012L18 gene	42	0.93
chr5_72948057_72948229	0.39	Slain2	SLAIN motif family, member 2	356	0.81
chr11_59443474_59443666	0.39	Snap47	synaptosomal-associated protein, 47	3921	0.13
chr3_65966244_65966401	0.38	Gm35106	predicted gene, 35106	2829	0.15
chr10_69585730_69585898	0.38	Gm46231	predicted gene, 46231	19453	0.24
chr5_112153903_112154070	0.38	1700016B01Rik	RIKEN cDNA 1700016B01 gene	2251	0.29
chr18_4974876_4975041	0.38	Svil	supervillin	18855	0.27
chr8_95802283_95802434	0.38	4930513N10Rik	RIKEN cDNA 4930513N10 gene	4386	0.1
chr2_65212598_65212873	0.38	Cobll1	Cobl-like 1	23260	0.17
chr1_59233451_59233602	0.37	Als2	alsin Rho guanine nucleotide exchange factor	3567	0.21
chr2_102941580_102941744	0.37	Cd44	CD44 antigen	39997	0.15
chr2_84637297_84637592	0.37	Ctnnd1	catenin (cadherin associated protein), delta 1	661	0.54
chr12_81949344_81949529	0.36	Pcnx	pecanex homolog	14211	0.22
chr3_84258598_84259173	0.36	Trim2	tripartite motif-containing 2	484	0.86
chr10_128822735_128822886	0.36	Sarnp	SAP domain containing ribonucleoprotein	878	0.31
chr2_3739821_3739975	0.36	Gm13185	predicted gene 13185	15279	0.17
chr6_17497862_17498049	0.36	Met	met proto-oncogene	6714	0.24
chr6_149146419_149146608	0.36	Etfbkmt	electron transfer flavoprotein beta subunit lysine methyltransferase	4867	0.14
chr12_17471269_17471420	0.36	Gm36752	predicted gene, 36752	34726	0.14
chr2_160868493_160868691	0.36	Zhx3	zinc fingers and homeoboxes 3	3980	0.16
chr17_71249896_71250070	0.36	Lpin2	lipin 2	3952	0.19
chr14_55459247_55459638	0.35	Dhrs4	dehydrogenase/reductase (SDR family) member 4	19316	0.09
chr7_46742642_46742793	0.35	Saa1	serum amyloid A 1	225	0.84
chr12_79673779_79674034	0.35	9430078K24Rik	RIKEN cDNA 9430078K24 gene	250827	0.02
chr17_46053127_46053311	0.35	Vegfa	vascular endothelial growth factor A	20850	0.13
chr7_28244175_28244405	0.35	Gm18672	predicted gene, 18672	8370	0.09
chr3_52648763_52649088	0.35	Gm10293	predicted pseudogene 10293	36090	0.17
chr4_95881579_95881746	0.35	Fggy	FGGY carbohydrate kinase domain containing	32037	0.19
chr8_124481322_124481478	0.34	Cog2	component of oligomeric golgi complex 2	39367	0.13
chr19_3562443_3562594	0.34	Ppp6r3	protein phosphatase 6, regulatory subunit 3	13178	0.15
chr16_45987509_45987734	0.34	Plcxd2	phosphatidylinositol-specific phospholipase C, X domain containing 2	22597	0.14
chr15_36578415_36578633	0.34	Gm44310	predicted gene, 44310	5020	0.15
chr1_188125975_188126247	0.33	Gm38315	predicted gene, 38315	34596	0.21
chr15_34501595_34501764	0.33	Pop1	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)	6356	0.12
chr18_65140941_65141092	0.33	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	2542	0.34
chr14_70763422_70763573	0.33	Dok2	docking protein 2	2539	0.24
chr13_36459154_36459328	0.33	Gm48763	predicted gene, 48763	39	0.98
chr16_79059250_79059443	0.33	Tmprss15	transmembrane protease, serine 15	31746	0.22
chr11_94370687_94371288	0.32	Abcc3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	3064	0.21
chr5_99284011_99284176	0.32	Gm35394	predicted gene, 35394	9998	0.24
chr8_120414524_120414709	0.32	Gm22715	predicted gene, 22715	28933	0.17
chr6_51681649_51681815	0.32	Gm38811	predicted gene, 38811	29349	0.19
chr15_59659799_59660177	0.31	Trib1	tribbles pseudokinase 1	11335	0.2
chr9_66625835_66625995	0.31	Usp3	ubiquitin specific peptidase 3	32773	0.16
chr15_3432918_3433085	0.31	Ghr	growth hormone receptor	38643	0.2
chr2_147999397_147999548	0.31	9030622O22Rik	RIKEN cDNA 9030622O22 gene	23287	0.18
chr10_8951296_8951475	0.31	Gm48728	predicted gene, 48728	564	0.78
chr17_46056098_46056295	0.31	Vegfa	vascular endothelial growth factor A	23827	0.12
chr4_97885703_97886090	0.30	Nfia	nuclear factor I/A	5777	0.31
chr16_10648544_10649119	0.30	Clec16a	C-type lectin domain family 16, member A	18771	0.16
chr16_81331237_81331468	0.30	Gm49555	predicted gene, 49555	41190	0.19
chr15_97032998_97033149	0.30	Slc38a4	solute carrier family 38, member 4	1862	0.46
chr19_23069533_23069684	0.30	C330002G04Rik	RIKEN cDNA C330002G04 gene	6245	0.2
chr3_129331898_129332432	0.29	Enpep	glutamyl aminopeptidase	99	0.96
chr13_34044303_34044743	0.29	Bphl	biphenyl hydrolase-like (serine hydrolase, breast epithelial mucin-associated antigen)	4682	0.12
chr10_88201239_88201853	0.28	Washc3	WASH complex subunit 3	283	0.88
chr17_34804558_34804741	0.28	Cyp21a1	cytochrome P450, family 21, subfamily a, polypeptide 1	88	0.9
chr15_34501830_34501985	0.28	Pop1	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)	6584	0.12
chr15_59121364_59121551	0.28	Mtss1	MTSS I-BAR domain containing 1	39452	0.16
chr9_106269146_106269548	0.28	Poc1a	POC1 centriolar protein A	11714	0.11
chr14_20985530_20985681	0.28	Vcl	vinculin	36398	0.15
chr13_82200174_82200343	0.28	Gm48155	predicted gene, 48155	110501	0.07
chr6_52191906_52192068	0.28	Hoxa4	homeobox A4	234	0.75
chr5_96304478_96304629	0.28	Fras1	Fraser extracellular matrix complex subunit 1	69402	0.11
chr14_73776184_73776350	0.28	Gm24540	predicted gene, 24540	8299	0.18
chr19_39675949_39676100	0.28	Cyp2c67	cytochrome P450, family 2, subfamily c, polypeptide 67	26973	0.21
chr14_66091491_66091642	0.28	Adam2	a disintegrin and metallopeptidase domain 2	13833	0.15
chr1_59426719_59426879	0.28	Gm37737	predicted gene, 37737	22703	0.15
chr2_155057003_155057377	0.27	a	nonagouti	9575	0.14
chr19_34525323_34525487	0.27	Lipa	lysosomal acid lipase A	2006	0.23
chr6_135444931_135445089	0.27	Emp1	epithelial membrane protein 1	77517	0.08
chr1_21245441_21245592	0.27	Gsta3	glutathione S-transferase, alpha 3	4887	0.13
chr19_45016995_45017146	0.27	Lzts2	leucine zipper, putative tumor suppressor 2	573	0.58
chr4_145037713_145037984	0.27	Vps13d	vacuolar protein sorting 13D	13186	0.24
chr17_10253710_10253861	0.27	Qk	quaking	29148	0.22
chr4_130721108_130721312	0.27	Snord85	small nucleolar RNA, C/D box 85	28424	0.12
chr12_104087776_104088197	0.27	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	7337	0.1
chr3_51187254_51187408	0.27	Noct	nocturnin	37116	0.12
chr11_28696545_28697113	0.27	2810471M01Rik	RIKEN cDNA 2810471M01 gene	15265	0.17
chr2_31492850_31493284	0.27	Ass1	argininosuccinate synthetase 1	4705	0.21
chr7_141273390_141273689	0.26	Cdhr5	cadherin-related family member 5	196	0.85
chr11_60045283_60045434	0.26	Pemt	phosphatidylethanolamine N-methyltransferase	1119	0.47
chr17_43361159_43361498	0.26	Adgrf5	adhesion G protein-coupled receptor F5	877	0.69
chr13_36459438_36459830	0.26	Gm48763	predicted gene, 48763	354	0.9
chr13_96981889_96982402	0.26	Gm48597	predicted gene, 48597	31231	0.12
chr2_163301297_163301733	0.26	Tox2	TOX high mobility group box family member 2	18863	0.19
chr13_95850293_95850468	0.26	Iqgap2	IQ motif containing GTPase activating protein 2	41377	0.14
chr15_89315569_89316024	0.25	Sbf1	SET binding factor 1	485	0.62
chr18_16667346_16667528	0.25	Cdh2	cadherin 2	2632	0.38
chr6_50037597_50037914	0.25	Gm3455	predicted gene 3455	13431	0.26
chr15_87045730_87045890	0.25	Gm23416	predicted gene, 23416	23183	0.18
chr19_12771696_12771894	0.25	Cntf	ciliary neurotrophic factor	6163	0.12
chr9_106261489_106261640	0.25	Alas1	aminolevulinic acid synthase 1	12910	0.1
chr4_48909780_48909970	0.25	Gm12436	predicted gene 12436	11282	0.2
chr7_120187961_120188112	0.25	Crym	crystallin, mu	14075	0.13
chr4_115575098_115575249	0.25	Cyp4b1-ps2	cytochrome P450, family 4, subfamily b, polypeptide 1, pseudogene 2	7971	0.12
chr10_53373661_53374052	0.25	Cep85l	centrosomal protein 85-like	2258	0.21
chr1_40254078_40254270	0.25	Il1r1	interleukin 1 receptor, type I	12412	0.19
chr10_54058863_54059129	0.25	Gm47917	predicted gene, 47917	4815	0.22
chr4_82453748_82453899	0.25	n-R5s188	nuclear encoded rRNA 5S 188	14413	0.22
chr3_138285092_138285352	0.25	Adh1	alcohol dehydrogenase 1 (class I)	7571	0.12
chr8_3457973_3458135	0.25	Gm44775	predicted gene 44775	15	0.96
chr16_57160316_57160467	0.25	Nit2	nitrilase family, member 2	250	0.9
chr4_45492047_45492219	0.24	Shb	src homology 2 domain-containing transforming protein B	708	0.64
chr9_103229092_103229718	0.24	Trf	transferrin	861	0.57
chr11_121193349_121193500	0.24	Hexdc	hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing	11009	0.1
chr18_4944915_4945098	0.24	Svil	supervillin	23280	0.25
chr16_38433421_38433613	0.24	Pla1a	phospholipase A1 member A	372	0.8
chr1_133371278_133371447	0.24	Etnk2	ethanolamine kinase 2	4075	0.16
chr8_75090012_75090291	0.24	Hmox1	heme oxygenase 1	3470	0.17
chr17_31446942_31447093	0.24	Pde9a	phosphodiesterase 9A	1350	0.29
chr8_93257060_93257211	0.24	Ces1f	carboxylesterase 1F	1604	0.3
chr3_95655803_95656050	0.24	Mcl1	myeloid cell leukemia sequence 1	2862	0.14
chr5_118679397_118679768	0.24	Gm43052	predicted gene 43052	8036	0.17
chr10_24229091_24229242	0.24	Moxd1	monooxygenase, DBH-like 1	5621	0.22
chr15_34501373_34501524	0.24	Pop1	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)	6125	0.12
chr12_28701154_28701305	0.24	Trappc12	trafficking protein particle complex 12	380	0.81
chr3_97903526_97903906	0.23	Sec22b	SEC22 homolog B, vesicle trafficking protein	2489	0.21
chr13_34724917_34725536	0.23	Gm47151	predicted gene, 47151	4475	0.13
chr6_100398724_100398900	0.23	Gm23234	predicted gene, 23234	96002	0.06
chr4_49149568_49149719	0.23	Plppr1	phospholipid phosphatase related 1	90187	0.08
chr2_134486534_134486685	0.23	Hao1	hydroxyacid oxidase 1, liver	67698	0.14
chr8_90870725_90870903	0.23	Gm45640	predicted gene 45640	5767	0.14
chr9_57644001_57644162	0.23	Csk	c-src tyrosine kinase	1028	0.39
chr8_45719244_45719451	0.23	Sorbs2	sorbin and SH3 domain containing 2	23834	0.18
chr7_80057574_80057769	0.23	Gm21057	predicted gene, 21057	17576	0.1
chr6_94690168_94690545	0.23	Lrig1	leucine-rich repeats and immunoglobulin-like domains 1	9726	0.23
chr1_172082204_172082395	0.23	Copa	coatomer protein complex subunit alpha	230	0.7
chr19_47317044_47317343	0.23	Sh3pxd2a	SH3 and PX domains 2A	2442	0.27
chr17_28031684_28031846	0.23	Anks1	ankyrin repeat and SAM domain containing 1	9010	0.12
chr3_144113744_144114175	0.23	Gm34078	predicted gene, 34078	21795	0.21
chr6_86848512_86848886	0.23	2610306M01Rik	RIKEN cDNA 2610306M01 gene	741	0.4
chr2_128786890_128787052	0.23	Gm23172	predicted gene, 23172	6595	0.15
chr2_169948040_169948351	0.23	AY702102	cDNA sequence AY702102	14792	0.26
chr6_17503345_17503773	0.23	Met	met proto-oncogene	12318	0.23
chr8_36283417_36283571	0.23	Lonrf1	LON peptidase N-terminal domain and ring finger 1	33978	0.16
chr9_35135640_35136007	0.23	Gm24262	predicted gene, 24262	8813	0.12
chr19_37436586_37437426	0.23	Hhex	hematopoietically expressed homeobox	267	0.85
chr10_81422614_81422782	0.23	Nfic	nuclear factor I/C	4416	0.07
chr2_60118945_60119257	0.23	Gm13620	predicted gene 13620	5995	0.16
chr10_115511796_115512121	0.23	Lgr5	leucine rich repeat containing G protein coupled receptor 5	48879	0.12
chr2_18677773_18678539	0.23	Bmi1	Bmi1 polycomb ring finger oncogene	349	0.82
chr7_16463346_16463509	0.23	n-R5s151	nuclear encoded rRNA 5S 151	8386	0.1
chr17_49455547_49455883	0.22	Mocs1	molybdenum cofactor synthesis 1	3431	0.28
chr9_49055894_49056116	0.22	Zw10	zw10 kinetochore protein	223	0.75
chr6_15828886_15829037	0.22	Gm43990	predicted gene, 43990	7128	0.25
chr9_107770327_107770857	0.22	Rbm5	RNA binding motif protein 5	97	0.94
chr8_79294026_79294186	0.22	Mmaa	methylmalonic aciduria (cobalamin deficiency) type A	574	0.59
chr2_23070585_23070870	0.22	Acbd5	acyl-Coenzyme A binding domain containing 5	1276	0.44
chr3_88440726_88440965	0.22	Mir7011	microRNA 7011	106	0.71
chr12_39373052_39373364	0.22	Gm47855	predicted gene, 47855	25348	0.22
chr1_67185796_67186060	0.22	Cps1	carbamoyl-phosphate synthetase 1	62902	0.11
chr5_135713964_135714115	0.22	Por	P450 (cytochrome) oxidoreductase	1966	0.2
chr12_101953826_101954166	0.22	Atxn3	ataxin 3	4152	0.17
chr10_39434414_39434685	0.22	Gm6963	predicted gene 6963	9553	0.2
chr11_107125936_107126087	0.22	Bptf	bromodomain PHD finger transcription factor	5911	0.17
chrX_49624123_49624288	0.22	Gm14719	predicted gene 14719	36755	0.15
chr8_35383605_35384049	0.22	Ppp1r3b	protein phosphatase 1, regulatory subunit 3B	7167	0.17
chr6_144895556_144895729	0.22	Gm22792	predicted gene, 22792	92010	0.07
chr7_134742344_134742654	0.21	Dock1	dedicator of cytokinesis 1	34956	0.2
chr11_48806124_48806302	0.21	Rack1	receptor for activated C kinase 1	765	0.41
chr16_49862441_49862599	0.21	Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	4313	0.32
chr4_35050067_35050634	0.21	Gm12364	predicted gene 12364	88130	0.07
chr19_37441259_37441628	0.21	Hhex	hematopoietically expressed homeobox	4704	0.13
chr5_72210270_72210469	0.21	Atp10d	ATPase, class V, type 10D	7016	0.2
chr6_59453276_59453536	0.21	Gprin3	GPRIN family member 3	27112	0.26
chr7_100011175_100011513	0.21	Chrdl2	chordin-like 2	1430	0.34
chr2_27421651_27421802	0.21	Vav2	vav 2 oncogene	5186	0.15
chr1_74230928_74231199	0.21	Arpc2	actin related protein 2/3 complex, subunit 2	5021	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.2	GO:1904339	negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.1	0.4	GO:0060283	negative regulation of oocyte development(GO:0060283)
0.1	0.2	GO:0030397	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.1	0.2	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.1	0.3	GO:0006549	isoleucine metabolic process(GO:0006549)
0.1	0.2	GO:0010046	response to mycotoxin(GO:0010046)
0.1	0.3	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.1	0.2	GO:0033092	positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.1	0.2	GO:0060978	angiogenesis involved in coronary vascular morphogenesis(GO:0060978)
0.1	0.3	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.1	0.2	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.2	GO:0009698	phenylpropanoid metabolic process(GO:0009698)
0.1	0.1	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.1	0.2	GO:0045297	mating plug formation(GO:0042628) post-mating behavior(GO:0045297)
0.1	0.2	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.2	GO:0050747	positive regulation of lipoprotein metabolic process(GO:0050747)
0.0	0.1	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.0	0.2	GO:1904970	brush border assembly(GO:1904970)
0.0	0.2	GO:0060431	primary lung bud formation(GO:0060431)
0.0	0.1	GO:0042998	positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.1	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.2	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.2	GO:0060368	regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368)
0.0	0.1	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.3	GO:0016078	tRNA catabolic process(GO:0016078)
0.0	0.1	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.1	GO:2000097	regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0	0.2	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.0	0.1	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0	0.1	GO:0090071	negative regulation of ribosome biogenesis(GO:0090071)
0.0	0.1	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.1	GO:0034454	microtubule anchoring at centrosome(GO:0034454)
0.0	0.1	GO:0003195	tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0046098	guanine metabolic process(GO:0046098)
0.0	0.1	GO:0035622	intrahepatic bile duct development(GO:0035622)
0.0	0.1	GO:0051025	negative regulation of immunoglobulin secretion(GO:0051025)
0.0	0.1	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.2	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.1	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.0	0.0	GO:0009157	deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0	0.1	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.2	GO:0042448	progesterone metabolic process(GO:0042448)
0.0	0.1	GO:0045079	negative regulation of chemokine biosynthetic process(GO:0045079)
0.0	0.1	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.2	GO:0071267	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.2	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.1	GO:1901856	negative regulation of cellular respiration(GO:1901856)
0.0	0.1	GO:1903546	protein localization to photoreceptor outer segment(GO:1903546)
0.0	0.1	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.4	GO:0060294	cilium movement involved in cell motility(GO:0060294)
0.0	0.1	GO:1900060	negative regulation of ceramide biosynthetic process(GO:1900060)
0.0	0.1	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0	0.2	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.2	GO:2000601	positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0	0.1	GO:0048320	axial mesoderm formation(GO:0048320)
0.0	0.1	GO:1990036	calcium ion import into sarcoplasmic reticulum(GO:1990036)
0.0	0.1	GO:0019853	L-ascorbic acid biosynthetic process(GO:0019853)
0.0	0.2	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0046084	adenine metabolic process(GO:0046083) adenine biosynthetic process(GO:0046084)
0.0	0.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0010796	regulation of multivesicular body size(GO:0010796)
0.0	0.1	GO:0018364	peptidyl-glutamine methylation(GO:0018364)
0.0	0.0	GO:0061668	mitochondrial ribosome assembly(GO:0061668)
0.0	0.1	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.4	GO:0015721	bile acid and bile salt transport(GO:0015721)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.2	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.1	GO:0090158	endoplasmic reticulum membrane organization(GO:0090158)
0.0	0.1	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:2001170	negative regulation of ATP biosynthetic process(GO:2001170)
0.0	0.1	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.3	GO:0007096	regulation of exit from mitosis(GO:0007096)
0.0	0.1	GO:0019482	beta-alanine metabolic process(GO:0019482)
0.0	0.4	GO:0007020	microtubule nucleation(GO:0007020)
0.0	0.0	GO:0044034	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.1	GO:0045415	negative regulation of interleukin-8 biosynthetic process(GO:0045415)
0.0	0.1	GO:0048597	post-embryonic camera-type eye morphogenesis(GO:0048597)
0.0	0.0	GO:1904261	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.1	GO:0015780	nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.1	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.1	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.1	GO:1900623	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.0	0.0	GO:0070460	thyroid-stimulating hormone secretion(GO:0070460)
0.0	0.0	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.1	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.1	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.1	GO:0009957	epidermal cell fate specification(GO:0009957)
0.0	0.0	GO:0010535	positive regulation of activation of JAK2 kinase activity(GO:0010535)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.1	GO:0002457	T cell antigen processing and presentation(GO:0002457)
0.0	0.1	GO:1902047	polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267)
0.0	0.1	GO:2000598	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.0	0.2	GO:0070129	regulation of mitochondrial translation(GO:0070129)
0.0	0.1	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0051138	regulation of NK T cell differentiation(GO:0051136) positive regulation of NK T cell differentiation(GO:0051138)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0046218	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.1	GO:0019896	axonal transport of mitochondrion(GO:0019896)
0.0	0.1	GO:0071679	commissural neuron axon guidance(GO:0071679)
0.0	0.1	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.0	0.1	GO:2000574	regulation of microtubule motor activity(GO:2000574)
0.0	0.1	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0	0.1	GO:0032819	positive regulation of natural killer cell proliferation(GO:0032819)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.0	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.0	GO:0052422	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0	0.1	GO:0000820	regulation of glutamine family amino acid metabolic process(GO:0000820)
0.0	0.1	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.1	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.0	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0	0.1	GO:0009092	homoserine metabolic process(GO:0009092) transsulfuration(GO:0019346)
0.0	0.1	GO:0006995	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0	0.1	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
0.0	0.1	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0	0.1	GO:0018242	protein O-linked glycosylation via serine(GO:0018242)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:2000686	regulation of rubidium ion transmembrane transporter activity(GO:2000686)
0.0	0.1	GO:0042420	dopamine catabolic process(GO:0042420)
0.0	0.1	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.0	GO:0060137	maternal process involved in parturition(GO:0060137)
0.0	0.0	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.0	GO:0035441	cell migration involved in vasculogenesis(GO:0035441)
0.0	0.0	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.0	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0	0.0	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.1	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.1	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.0	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.0	GO:0046985	positive regulation of hemoglobin biosynthetic process(GO:0046985)
0.0	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	0.2	GO:0015012	heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0	0.0	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.0	0.1	GO:0090427	activation of meiosis(GO:0090427)
0.0	0.1	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.0	0.1	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.1	GO:0060028	convergent extension involved in axis elongation(GO:0060028)
0.0	0.0	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.1	GO:0030953	astral microtubule organization(GO:0030953)
0.0	0.0	GO:0072497	mesenchymal stem cell differentiation(GO:0072497)
0.0	0.0	GO:0010387	COP9 signalosome assembly(GO:0010387)
0.0	0.1	GO:0071455	cellular response to increased oxygen levels(GO:0036295) cellular response to hyperoxia(GO:0071455)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.1	GO:0031914	negative regulation of synaptic plasticity(GO:0031914)
0.0	0.0	GO:0032532	regulation of microvillus length(GO:0032532)
0.0	0.1	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0	0.0	GO:0090666	scaRNA localization to Cajal body(GO:0090666)
0.0	0.0	GO:2000384	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.0	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0051639	actin filament network formation(GO:0051639)
0.0	0.1	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.0	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.0	GO:1904177	regulation of adipose tissue development(GO:1904177)
0.0	0.2	GO:0000154	rRNA modification(GO:0000154)
0.0	0.1	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.1	GO:0060510	Type II pneumocyte differentiation(GO:0060510)
0.0	0.0	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.0	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.2	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.0	GO:0055099	response to high density lipoprotein particle(GO:0055099)
0.0	0.1	GO:0032239	regulation of nucleobase-containing compound transport(GO:0032239)
0.0	0.2	GO:0043171	peptide catabolic process(GO:0043171)
0.0	0.1	GO:0031133	regulation of axon diameter(GO:0031133)
0.0	0.1	GO:0009435	NAD biosynthetic process(GO:0009435)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.0	GO:0061084	negative regulation of protein refolding(GO:0061084)
0.0	0.1	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.0	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.0	GO:0035928	rRNA import into mitochondrion(GO:0035928)
0.0	0.1	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.0	0.2	GO:0030157	pancreatic juice secretion(GO:0030157)
0.0	0.0	GO:0043633	polyadenylation-dependent RNA catabolic process(GO:0043633)
0.0	0.1	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.0	GO:0035627	ceramide transport(GO:0035627)
0.0	0.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.1	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.1	GO:0051694	pointed-end actin filament capping(GO:0051694)
0.0	0.3	GO:0032008	positive regulation of TOR signaling(GO:0032008)
0.0	0.0	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.0	0.0	GO:0070574	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0075509	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.1	GO:0045607	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.0	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0	0.0	GO:0060051	negative regulation of protein glycosylation(GO:0060051)
0.0	0.1	GO:0006855	drug transmembrane transport(GO:0006855)
0.0	0.0	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.0	GO:0032202	telomere assembly(GO:0032202)
0.0	0.0	GO:0048840	otolith development(GO:0048840)
0.0	0.1	GO:0034453	microtubule anchoring(GO:0034453)
0.0	0.0	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.1	GO:0009226	nucleotide-sugar biosynthetic process(GO:0009226)
0.0	0.0	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.1	GO:0031665	negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665)
0.0	0.0	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.0	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.0	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:0070862	negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0	0.0	GO:0010519	negative regulation of phospholipase activity(GO:0010519)
0.0	0.0	GO:0022009	central nervous system vasculogenesis(GO:0022009)
0.0	0.1	GO:0006563	L-serine metabolic process(GO:0006563)
0.0	0.0	GO:2000338	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.0	GO:0035625	receptor transactivation(GO:0035624) epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway(GO:0035625)
0.0	0.1	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.1	0.3	GO:0036449	microtubule minus-end(GO:0036449)
0.1	0.2	GO:0070939	Dsl1p complex(GO:0070939)
0.1	0.2	GO:0042567	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.3	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.0	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.1	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.2	GO:0089717	spanning component of plasma membrane(GO:0044214) spanning component of membrane(GO:0089717)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.3	GO:1990909	Wnt signalosome(GO:1990909)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.1	GO:0030478	actin cap(GO:0030478)
0.0	0.1	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.0	0.2	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.2	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0043527	tRNA methyltransferase complex(GO:0043527)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0035339	SPOTS complex(GO:0035339)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.3	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.4	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.1	GO:0036194	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0	0.2	GO:0030128	clathrin coat of endocytic vesicle(GO:0030128)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.2	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.1	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0001652	granular component(GO:0001652)
0.0	0.1	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.1	GO:0033503	HULC complex(GO:0033503)
0.0	0.1	GO:0097342	ripoptosome(GO:0097342)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0097470	ribbon synapse(GO:0097470)
0.0	0.1	GO:0000346	transcription export complex(GO:0000346)
0.0	0.0	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	0.0	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.0	0.0	GO:0097413	Lewy body(GO:0097413)
0.0	0.1	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
0.0	0.3	GO:0002080	acrosomal membrane(GO:0002080)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.0	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.0	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.0	GO:1990752	microtubule end(GO:1990752)
0.0	0.1	GO:0042555	MCM complex(GO:0042555)
0.0	0.1	GO:0001891	phagocytic cup(GO:0001891)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.1	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.0	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0000782	telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0	0.0	GO:0034448	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	0.1	GO:0031229	integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.0	0.0	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.0	GO:0030015	CCR4-NOT core complex(GO:0030015)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1	0.2	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.1	0.3	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.1	0.2	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.1	0.2	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.1	0.2	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.3	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.1	0.2	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.2	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.2	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.2	GO:0016744	transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.2	GO:0050051	leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.0	0.1	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.2	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.3	GO:0097027	ubiquitin-protein transferase activator activity(GO:0097027)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.2	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.2	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.1	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0030911	TPR domain binding(GO:0030911)
0.0	0.2	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.2	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.2	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0	0.1	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.3	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.0	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0032453	histone demethylase activity (H3-K4 specific)(GO:0032453)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0070699	type II activin receptor binding(GO:0070699)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.0	GO:0051765	inositol tetrakisphosphate kinase activity(GO:0051765)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.1	GO:0005138	interleukin-6 receptor binding(GO:0005138)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.6	GO:0042056	chemoattractant activity(GO:0042056)
0.0	0.1	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.1	GO:0019959	interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0017151	DEAD/H-box RNA helicase binding(GO:0017151)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0097108	hedgehog family protein binding(GO:0097108)
0.0	0.0	GO:0000701	purine-specific mismatch base pair DNA N-glycosylase activity(GO:0000701)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.2	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.1	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.2	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.1	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.1	GO:0051011	microtubule minus-end binding(GO:0051011)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.0	0.1	GO:0002054	nucleobase binding(GO:0002054)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.2	GO:0070006	metalloaminopeptidase activity(GO:0070006)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)
0.0	0.0	GO:0032190	acrosin binding(GO:0032190)
0.0	0.0	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.0	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.1	GO:0019136	deoxynucleoside kinase activity(GO:0019136)
0.0	0.2	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.0	GO:0030620	U2 snRNA binding(GO:0030620)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.0	GO:0046538	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	0.0	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	0.1	GO:0070878	primary miRNA binding(GO:0070878)
0.0	0.1	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0003847	1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.0	0.0	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
0.0	0.1	GO:0003958	NADPH-hemoprotein reductase activity(GO:0003958)
0.0	0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.1	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.0	GO:0016662	oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662)
0.0	0.0	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0005068	transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0	0.0	GO:0034040	lipid-transporting ATPase activity(GO:0034040)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.0	GO:0070905	serine binding(GO:0070905)
0.0	0.0	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.1	GO:0001055	RNA polymerase II activity(GO:0001055)
0.0	0.2	GO:0005521	lamin binding(GO:0005521)
0.0	0.0	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.0	GO:0000253	3-keto sterol reductase activity(GO:0000253)
0.0	0.0	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.0	GO:0015375	glycine:sodium symporter activity(GO:0015375)
0.0	0.0	GO:0017089	glycolipid transporter activity(GO:0017089)
0.0	0.2	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.0	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.0	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.0	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.2	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.0	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.0	GO:0036435	K48-linked polyubiquitin binding(GO:0036435)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0005388	calcium-transporting ATPase activity(GO:0005388)
0.0	0.5	GO:0002161	aminoacyl-tRNA editing activity(GO:0002161)
0.0	0.1	GO:0008656	cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.0	0.3	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0016653	oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.0	0.1	GO:0050072	m7G(5')pppN diphosphatase activity(GO:0050072)
0.0	0.1	GO:0001223	transcription coactivator binding(GO:0001223)
0.0	0.0	GO:0004936	alpha-adrenergic receptor activity(GO:0004936) alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.0	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.0	GO:0051425	PTB domain binding(GO:0051425)
0.0	0.1	GO:0043733	alkylbase DNA N-glycosylase activity(GO:0003905) DNA-3-methylbase glycosylase activity(GO:0043733)
0.0	0.0	GO:0001069	regulatory region RNA binding(GO:0001069)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.3	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.1	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	0.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.0	0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.0	0.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.0	0.1	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.1	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	0.2	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.0	0.4	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.2	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.3	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.4	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.2	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.1	REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	Genes involved in NGF signalling via TRKA from the plasma membrane
0.2	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.3	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.2	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.1	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	REACTOME CD28 DEPENDENT VAV1 PATHWAY	Genes involved in CD28 dependent Vav1 pathway
0.0	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.1	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.2	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	REACTOME CD28 CO STIMULATION	Genes involved in CD28 co-stimulation
0.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.1	REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1	Genes involved in IKK complex recruitment mediated by RIP1
0.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS	Genes involved in Interactions of Vpr with host cellular proteins
0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions