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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hoxa4

Z-value: 0.97

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Transcription factors associated with Hoxa4

Gene Symbol	Gene ID	Gene Info
Hoxa4 Ensembl NCBI MGI UniProt	ENSMUSG00000000942.10	Hoxa4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hoxa4	chr6_52191906_52192068	234	0.752593	-0.18	7.4e-01	Click!

Activity of the Hoxa4 motif across conditions

Conditions sorted by the z-value of the Hoxa4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr19_44401904_44402310	0.53	Scd1	stearoyl-Coenzyme A desaturase 1	4583	0.17
chr19_36264512_36264835	0.44	Gm32027	predicted gene, 32027	236	0.93
chr17_25446180_25446342	0.44	Tekt4	tektin 4	8354	0.11
chr8_93167580_93167731	0.41	Ces1d	carboxylesterase 1D	2320	0.22
chr3_118606217_118606485	0.40	Dpyd	dihydropyrimidine dehydrogenase	44165	0.15
chr15_3475054_3475205	0.38	Ghr	growth hormone receptor	3485	0.35
chr15_4641921_4642072	0.38	C6	complement component 6	85179	0.09
chr8_93176743_93176912	0.37	Ces1d	carboxylesterase 1D	1538	0.3
chr12_104087776_104088197	0.36	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	7337	0.1
chr9_122848915_122849207	0.36	Gm47140	predicted gene, 47140	643	0.55
chr19_44402814_44402965	0.34	Scd1	stearoyl-Coenzyme A desaturase 1	3801	0.18
chr3_51230467_51230865	0.34	Gm38357	predicted gene, 38357	1251	0.37
chr10_4613331_4613709	0.33	Esr1	estrogen receptor 1 (alpha)	1499	0.46
chr3_76637152_76637321	0.33	Fstl5	follistatin-like 5	43686	0.19
chr5_125524109_125525122	0.33	Tmem132b	transmembrane protein 132B	7159	0.16
chr12_51689904_51690055	0.33	Ap4s1	adaptor-related protein complex AP-4, sigma 1	1054	0.46
chr10_87896571_87896873	0.32	Igf1os	insulin-like growth factor 1, opposite strand	33341	0.15
chr15_3463620_3463812	0.31	Ghr	growth hormone receptor	7928	0.3
chr11_28690043_28690210	0.31	2810471M01Rik	RIKEN cDNA 2810471M01 gene	8562	0.19
chr2_58790704_58790855	0.30	Upp2	uridine phosphorylase 2	25454	0.18
chr7_19508824_19509003	0.30	Trappc6a	trafficking protein particle complex 6A	183	0.76
chr8_93258234_93258385	0.30	Ces1f	carboxylesterase 1F	430	0.78
chr1_67236092_67236243	0.29	Gm15668	predicted gene 15668	13033	0.22
chr4_102576883_102577034	0.28	Pde4b	phosphodiesterase 4B, cAMP specific	6863	0.31
chr8_23031563_23031855	0.28	Ank1	ankyrin 1, erythroid	3390	0.23
chr4_46832518_46832720	0.28	Gabbr2	gamma-aminobutyric acid (GABA) B receptor, 2	27283	0.22
chr12_80336463_80336614	0.28	Dcaf5	DDB1 and CUL4 associated factor 5	40154	0.1
chr2_35193405_35193556	0.27	Rab14	RAB14, member RAS oncogene family	817	0.57
chr8_93165469_93165620	0.27	Ces1d	carboxylesterase 1D	4431	0.16
chr6_22001861_22002013	0.27	Cped1	cadherin-like and PC-esterase domain containing 1	15045	0.24
chr2_50283993_50284144	0.27	Mmadhc	methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria	5131	0.24
chr1_67227779_67227978	0.27	Gm15668	predicted gene 15668	21322	0.2
chr19_4766055_4766206	0.27	Gm37206	predicted gene, 37206	959	0.35
chr9_23436438_23436789	0.27	Bmper	BMP-binding endothelial regulator	62681	0.16
chr5_51876698_51876972	0.27	Gm42616	predicted gene 42616	2767	0.24
chr1_55699716_55699934	0.26	Plcl1	phospholipase C-like 1	2200	0.43
chr4_102558090_102558267	0.26	Pde4b	phosphodiesterase 4B, cAMP specific	11917	0.3
chr13_96674138_96674322	0.26	Hmgcr	3-hydroxy-3-methylglutaryl-Coenzyme A reductase	3294	0.19
chr4_47366562_47366857	0.26	Tgfbr1	transforming growth factor, beta receptor I	13099	0.22
chr14_116240919_116241084	0.26	Gm20713	predicted gene 20713	369723	0.01
chr2_58773576_58773851	0.26	Upp2	uridine phosphorylase 2	8388	0.21
chr15_38049613_38049764	0.26	Gm22353	predicted gene, 22353	8597	0.16
chr12_99858543_99858709	0.26	Efcab11	EF-hand calcium binding domain 11	24231	0.11
chr3_111102424_111102592	0.26	Gm43407	predicted gene 43407	5992	0.34
chr1_50685464_50685672	0.26	Gm28321	predicted gene 28321	129807	0.05
chr13_95792630_95792781	0.25	Iqgap2	IQ motif containing GTPase activating protein 2	28308	0.16
chr3_158035265_158035416	0.25	Gm43362	predicted gene 43362	1069	0.28
chr2_34775525_34776380	0.25	Hspa5	heat shock protein 5	1105	0.4
chr2_122251200_122251358	0.25	Sord	sorbitol dehydrogenase	16530	0.1
chr11_117599771_117599931	0.25	2900041M22Rik	RIKEN cDNA 2900041M22 gene	11396	0.18
chr18_34948918_34949069	0.25	Hspa9	heat shock protein 9	869	0.45
chr13_46153184_46153335	0.25	Gm10113	predicted gene 10113	37787	0.19
chr16_26619429_26619580	0.25	Il1rap	interleukin 1 receptor accessory protein	4652	0.32
chr17_28502859_28503010	0.24	Fkbp5	FK506 binding protein 5	4472	0.09
chr10_31517928_31518079	0.24	Gm47693	predicted gene, 47693	39437	0.12
chr6_72098587_72098738	0.24	St3gal5	ST3 beta-galactoside alpha-2,3-sialyltransferase 5	905	0.44
chr6_29820680_29820831	0.24	Ahcyl2	S-adenosylhomocysteine hydrolase-like 2	18896	0.17
chr6_67268305_67268456	0.24	Serbp1	serpine1 mRNA binding protein 1	1050	0.44
chr4_122983111_122983491	0.24	Mycl	v-myc avian myelocytomatosis viral oncogene lung carcinoma derived	12351	0.13
chr3_57448360_57448527	0.24	Tm4sf4	transmembrane 4 superfamily member 4	23129	0.19
chr14_67053186_67053337	0.24	Ppp2r2a	protein phosphatase 2, regulatory subunit B, alpha	9732	0.17
chr2_64059065_64059258	0.24	Fign	fidgetin	38827	0.23
chr12_104346905_104347119	0.24	Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	8526	0.12
chr14_21033937_21034339	0.23	Vcl	vinculin	12135	0.18
chr19_44404359_44404510	0.23	Scd1	stearoyl-Coenzyme A desaturase 1	2256	0.23
chr1_67208135_67208300	0.23	Gm15668	predicted gene 15668	40983	0.16
chr9_48737248_48737430	0.23	Zbtb16	zinc finger and BTB domain containing 16	98606	0.07
chr6_138145599_138145922	0.23	Mgst1	microsomal glutathione S-transferase 1	2906	0.37
chr2_122737415_122737579	0.23	Bloc1s6os	biogenesis of lysosomal organelles complex-1, subunit 6, pallidin, opposite strand	865	0.39
chr12_99861381_99861532	0.23	Efcab11	EF-hand calcium binding domain 11	21401	0.12
chr6_66963164_66963414	0.23	Gm36816	predicted gene, 36816	45124	0.08
chr9_74881714_74881880	0.23	Onecut1	one cut domain, family member 1	15313	0.15
chr5_125522928_125523080	0.22	Aacs	acetoacetyl-CoA synthetase	7761	0.16
chr7_49290770_49290970	0.22	Nav2	neuron navigator 2	13268	0.23
chr2_118306989_118307215	0.22	1700054M17Rik	RIKEN cDNA 1700054M17 gene	2188	0.23
chr7_118181720_118181871	0.22	Smg1	SMG1 homolog, phosphatidylinositol 3-kinase-related kinase (C. elegans)	10496	0.16
chr6_72125643_72125794	0.22	4933431G14Rik	RIKEN cDNA 4933431G14 gene	2521	0.19
chr3_121735675_121736039	0.22	F3	coagulation factor III	6310	0.11
chr7_64802263_64802423	0.22	Fam189a1	family with sequence similarity 189, member A1	28691	0.19
chr15_10485447_10485602	0.22	Brix1	BRX1, biogenesis of ribosomes	139	0.83
chr5_51162183_51162334	0.22	Gm44377	predicted gene, 44377	61416	0.14
chr17_28428613_28428954	0.22	Fkbp5	FK506 binding protein 5	154	0.91
chr12_72768361_72768564	0.22	Ppm1a	protein phosphatase 1A, magnesium dependent, alpha isoform	7147	0.2
chr19_17599285_17599457	0.22	Gm17819	predicted gene, 17819	93392	0.08
chr2_122206384_122206535	0.21	Gm14050	predicted gene 14050	1461	0.25
chr10_28123601_28123752	0.21	Ptprk	protein tyrosine phosphatase, receptor type, K	48666	0.15
chr13_9145204_9145368	0.21	Gm28155	predicted gene 28155	4405	0.19
chr11_80383442_80384000	0.21	Zfp207	zinc finger protein 207	324	0.87
chr6_124758482_124758633	0.21	Atn1	atrophin 1	2033	0.1
chr13_63665698_63665976	0.21	Gm47387	predicted gene, 47387	4040	0.18
chr7_73608284_73608633	0.21	Gm44734	predicted gene 44734	490	0.68
chr19_44416577_44416796	0.21	Gm50337	predicted gene, 50337	2924	0.2
chr13_44437957_44438156	0.21	1700029N11Rik	RIKEN cDNA 1700029N11 gene	1656	0.27
chr3_60965282_60965682	0.21	P2ry1	purinergic receptor P2Y, G-protein coupled 1	37313	0.16
chr10_37139504_37139765	0.21	5930403N24Rik	RIKEN cDNA 5930403N24 gene	76	0.93
chr7_119978745_119978903	0.21	Gm25217	predicted gene, 25217	9003	0.16
chr10_67107041_67107217	0.21	Reep3	receptor accessory protein 3	10184	0.2
chr10_53373661_53374052	0.21	Cep85l	centrosomal protein 85-like	2258	0.21
chr3_18123292_18123443	0.21	Gm23726	predicted gene, 23726	54041	0.12
chr5_147545326_147545477	0.21	Pan3	PAN3 poly(A) specific ribonuclease subunit	6124	0.21
chr10_87051307_87051578	0.21	1700113H08Rik	RIKEN cDNA 1700113H08 gene	6603	0.2
chr2_121419496_121419659	0.21	Pdia3	protein disulfide isomerase associated 3	5053	0.08
chr12_52464277_52464428	0.21	Gm47431	predicted gene, 47431	16227	0.17
chr2_24892753_24892952	0.21	Gm37139	predicted gene, 37139	1014	0.3
chr1_100656422_100656580	0.20	Gm29334	predicted gene 29334	2701	0.31
chr11_17736440_17736720	0.20	Gm12016	predicted gene 12016	97397	0.08
chr7_78896045_78896424	0.20	Aen	apoptosis enhancing nuclease	225	0.89
chr5_134295659_134295849	0.20	Gtf2i	general transcription factor II I	146	0.93
chr13_96742797_96742948	0.20	Ankrd31	ankyrin repeat domain 31	5400	0.2
chr3_52270975_52271214	0.20	Gm20402	predicted gene 20402	1659	0.26
chr15_3500655_3500833	0.20	Ghr	growth hormone receptor	29100	0.23
chr2_121438376_121438543	0.20	Ell3	elongation factor RNA polymerase II-like 3	2692	0.11
chr2_31485846_31486386	0.20	Ass1	argininosuccinate synthetase 1	11656	0.18
chr2_30378803_30378994	0.20	Miga2	mitoguardin 2	663	0.51
chr11_110431257_110431440	0.20	Map2k6	mitogen-activated protein kinase kinase 6	32089	0.21
chr16_30110807_30110970	0.20	Gm20040	predicted gene, 20040	18006	0.13
chr2_128378785_128378975	0.20	Morrbid	myeloid RNA regulator of BCL2L11 induced cell death	24085	0.18
chr14_122878269_122878430	0.20	Pcca	propionyl-Coenzyme A carboxylase, alpha polypeptide	2414	0.29
chr10_15746557_15746708	0.20	Gm32283	predicted gene, 32283	7810	0.18
chr5_89462792_89462945	0.20	Gc	vitamin D binding protein	4970	0.25
chr9_41328613_41328764	0.20	Mir100hg	Mir100 Mirlet7a-2 Mir125b-1 cluster host gene	78	0.97
chr3_60576910_60577122	0.20	Mbnl1	muscleblind like splicing factor 1	18625	0.19
chr11_28685801_28685952	0.20	2810471M01Rik	RIKEN cDNA 2810471M01 gene	4312	0.22
chr3_29732375_29732526	0.19	Gm37557	predicted gene, 37557	38834	0.19
chr14_8003568_8003795	0.19	Abhd6	abhydrolase domain containing 6	715	0.66
chr6_85095404_85095555	0.19	Gm43955	predicted gene, 43955	1448	0.21
chr3_97632897_97633210	0.19	Fmo5	flavin containing monooxygenase 5	4170	0.16
chr17_46046958_46047109	0.19	Vegfa	vascular endothelial growth factor A	14664	0.14
chr7_140724826_140724998	0.19	Olfr542-ps1	olfactory receptor 542, pseudogene 1	3630	0.12
chr17_28025808_28026411	0.19	Anks1	ankyrin repeat and SAM domain containing 1	14666	0.11
chr8_25776385_25776540	0.19	Bag4	BCL2-associated athanogene 4	1120	0.32
chr2_156152255_156152428	0.19	Romo1	reactive oxygen species modulator 1	8101	0.1
chr2_128377567_128377751	0.19	Morrbid	myeloid RNA regulator of BCL2L11 induced cell death	25306	0.18
chr2_84637297_84637592	0.19	Ctnnd1	catenin (cadherin associated protein), delta 1	661	0.54
chr10_28166717_28166892	0.19	Gm22370	predicted gene, 22370	47317	0.17
chr2_31513022_31513372	0.19	Ass1	argininosuccinate synthetase 1	5293	0.19
chr10_24486336_24486502	0.19	Gm15272	predicted gene 15272	28092	0.16
chr3_136853089_136853240	0.19	Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	18471	0.2
chr19_56533507_56533720	0.19	Dclre1a	DNA cross-link repair 1A	3769	0.23
chr9_48733643_48733794	0.19	Zbtb16	zinc finger and BTB domain containing 16	102227	0.06
chr5_139559359_139559510	0.19	Uncx	UNC homeobox	15536	0.17
chr10_15748693_15748844	0.19	Gm32283	predicted gene, 32283	9946	0.18
chr11_90686948_90687471	0.18	Tom1l1	target of myb1-like 1 (chicken)	370	0.89
chr4_108425790_108426145	0.18	Gpx7	glutathione peroxidase 7	19006	0.1
chr6_29571610_29572022	0.18	Tnpo3	transportin 3	297	0.87
chr10_89530174_89530325	0.18	Nr1h4	nuclear receptor subfamily 1, group H, member 4	3336	0.26
chr6_37542487_37542638	0.18	Gm7463	predicted gene 7463	1148	0.52
chr10_87532342_87532676	0.18	Pah	phenylalanine hydroxylase	10482	0.2
chr12_84361536_84361697	0.18	Coq6	coenzyme Q6 monooxygenase	41	0.67
chr8_40564203_40564371	0.18	Vps37a	vacuolar protein sorting 37A	20863	0.15
chr9_86486034_86486185	0.18	Dop1a	DOP1 leucine zipper like protein A	702	0.68
chr11_88841479_88841856	0.18	Akap1	A kinase (PRKA) anchor protein 1	127	0.96
chr15_3512657_3512808	0.18	Ghr	growth hormone receptor	41088	0.19
chr15_35886635_35886786	0.18	Vps13b	vacuolar protein sorting 13B	14988	0.16
chr10_34326839_34326990	0.18	Nt5dc1	5'-nucleotidase domain containing 1	13231	0.13
chr19_32622727_32622878	0.18	Papss2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	2797	0.32
chr3_34483929_34484290	0.18	Gm29135	predicted gene 29135	1902	0.34
chr7_115795674_115795828	0.18	Sox6	SRY (sex determining region Y)-box 6	28959	0.24
chr7_136457949_136458342	0.18	Gm36849	predicted gene, 36849	104781	0.07
chr6_145855503_145855668	0.18	Gm43909	predicted gene, 43909	7712	0.17
chr19_48883437_48883771	0.18	Gm50436	predicted gene, 50436	72468	0.11
chr3_118592516_118592739	0.18	Dpyd	dihydropyrimidine dehydrogenase	30441	0.17
chr7_136406426_136406609	0.18	Gm36849	predicted gene, 36849	53153	0.14
chr12_41068657_41068813	0.18	Immp2l	IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae)	423	0.86
chr15_3463467_3463618	0.18	Ghr	growth hormone receptor	8102	0.29
chr16_54907388_54907558	0.18	Gm22977	predicted gene, 22977	64958	0.13
chr16_35401691_35401895	0.17	Pdia5	protein disulfide isomerase associated 5	11382	0.13
chr4_95992355_95992506	0.17	Hook1	hook microtubule tethering protein 1	10016	0.18
chr12_70999972_71000123	0.17	Psma3	proteasome subunit alpha 3	13155	0.14
chr11_16780814_16780965	0.17	Egfr	epidermal growth factor receptor	28659	0.16
chr3_51204305_51204466	0.17	Noct	nocturnin	20062	0.14
chr8_94399242_94399642	0.17	Ap3s1-ps2	adaptor-related protein complex 3, sigma 1 subunit, pseudogene 2	5769	0.11
chr3_107279311_107279673	0.17	Lamtor5	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	493	0.74
chr13_119966643_119967735	0.17	Gm20784	predicted gene, 20784	4945	0.11
chr9_122127991_122128201	0.17	4632418H02Rik	RIKEN cDNA 4632418H02 gene	802	0.5
chr11_106889132_106889465	0.17	Smurf2	SMAD specific E3 ubiquitin protein ligase 2	30977	0.11
chr4_123990670_123991070	0.17	Gm12902	predicted gene 12902	64636	0.08
chr16_36987638_36987887	0.17	Fbxo40	F-box protein 40	2705	0.19
chr3_18138170_18138321	0.17	Gm23686	predicted gene, 23686	39380	0.16
chr5_87089108_87089304	0.17	Ugt2b36	UDP glucuronosyltransferase 2 family, polypeptide B36	1951	0.22
chr11_5096479_5096889	0.17	Rhbdd3	rhomboid domain containing 3	2242	0.19
chr19_20614762_20614977	0.17	Aldh1a1	aldehyde dehydrogenase family 1, subfamily A1	12908	0.21
chr19_17599754_17599928	0.17	Gm17819	predicted gene, 17819	92922	0.09
chr6_37782285_37782449	0.17	Atp6v0c-ps2	ATPase, H+ transporting, lysosomal V0 subunit C, pseudogene 2	23719	0.21
chr9_113127097_113127258	0.17	Gm36251	predicted gene, 36251	4148	0.32
chr3_97643032_97643186	0.17	Fmo5	flavin containing monooxygenase 5	14226	0.12
chr13_119966017_119966201	0.17	Gm20784	predicted gene, 20784	3865	0.12
chr3_142862185_142862381	0.17	Pkn2	protein kinase N2	6548	0.15
chr9_43258125_43258276	0.17	D630033O11Rik	RIKEN cDNA D630033O11 gene	1680	0.32
chr2_34828383_34828580	0.17	Fbxw2	F-box and WD-40 domain protein 2	2170	0.17
chr19_40168031_40168182	0.17	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	19180	0.15
chr2_109714999_109715174	0.17	Bdnf	brain derived neurotrophic factor	5703	0.22
chr14_40032524_40032701	0.17	Gm25012	predicted gene, 25012	22710	0.21
chr4_62102548_62102834	0.17	Gm12910	predicted gene 12910	10240	0.13
chr3_97638864_97639015	0.17	Fmo5	flavin containing monooxygenase 5	10056	0.13
chr1_106267814_106267970	0.17	Phlpp1	PH domain and leucine rich repeat protein phosphatase 1	13533	0.22
chr6_72865575_72865746	0.17	Kcmf1	potassium channel modulatory factor 1	6766	0.18
chr16_93353844_93354010	0.17	1810053B23Rik	RIKEN cDNA 1810053B23 gene	134	0.96
chr7_100609367_100609521	0.17	Mrpl48	mitochondrial ribosomal protein L48	1143	0.29
chr5_99262128_99262472	0.16	Rasgef1b	RasGEF domain family, member 1B	9373	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxa4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.5	GO:0046449	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1	0.3	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.3	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1	0.2	GO:1903232	melanosome assembly(GO:1903232)
0.1	0.2	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.1	0.4	GO:0006526	arginine biosynthetic process(GO:0006526)
0.1	0.2	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.1	0.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.1	0.2	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.0	0.1	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0	0.2	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.2	GO:0045875	negative regulation of sister chromatid cohesion(GO:0045875)
0.0	0.1	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.0	0.2	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.1	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.0	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.1	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.1	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	0.1	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.1	GO:0072318	clathrin coat disassembly(GO:0072318)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.1	GO:2001274	negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.0	0.1	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.1	GO:0090187	positive regulation of pancreatic juice secretion(GO:0090187)
0.0	0.2	GO:0006627	protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0	0.1	GO:0015747	urate transport(GO:0015747)
0.0	0.1	GO:1902915	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:0061043	regulation of vascular wound healing(GO:0061043)
0.0	0.1	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.0	0.1	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.1	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0	0.1	GO:1900226	negative regulation of NLRP3 inflammasome complex assembly(GO:1900226)
0.0	0.1	GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0	0.1	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.0	0.1	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:0042780	tRNA 3'-end processing(GO:0042780)
0.0	0.1	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.0	0.1	GO:0043465	regulation of fermentation(GO:0043465) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.0	0.1	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.2	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.1	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061419)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.1	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.0	0.1	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.2	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.3	GO:0006743	ubiquinone metabolic process(GO:0006743)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:0010912	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.0	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.0	0.0	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.1	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.1	GO:0046881	positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.0	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.1	GO:0021779	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0	0.1	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.0	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.2	GO:0045176	apical protein localization(GO:0045176)
0.0	0.1	GO:0046485	ether lipid metabolic process(GO:0046485)
0.0	0.1	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	0.0	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.0	0.1	GO:0072309	mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309)
0.0	0.1	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.1	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.1	GO:0042045	epithelial fluid transport(GO:0042045)
0.0	0.0	GO:0070375	ERK5 cascade(GO:0070375)
0.0	0.1	GO:0032849	positive regulation of cellular pH reduction(GO:0032849)
0.0	0.1	GO:0035973	aggrephagy(GO:0035973)
0.0	0.5	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.0	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0	0.1	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.0	0.0	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.3	GO:0061462	protein localization to lysosome(GO:0061462)
0.0	0.0	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.3	GO:0000413	protein peptidyl-prolyl isomerization(GO:0000413)
0.0	0.1	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.0	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.0	GO:1904222	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.0	GO:0030397	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.0	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.1	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.0	GO:0071455	cellular response to increased oxygen levels(GO:0036295) cellular response to hyperoxia(GO:0071455)
0.0	0.0	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.0	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.0	GO:0045726	positive regulation of integrin biosynthetic process(GO:0045726)
0.0	0.1	GO:0033299	secretion of lysosomal enzymes(GO:0033299)
0.0	0.1	GO:0001880	Mullerian duct regression(GO:0001880)
0.0	0.1	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.2	GO:0051481	negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.0	0.0	GO:0045112	integrin biosynthetic process(GO:0045112)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.0	0.0	GO:0044597	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.0	GO:2000809	positive regulation of synaptic vesicle clustering(GO:2000809)
0.0	0.0	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.1	GO:0072592	oxygen metabolic process(GO:0072592)
0.0	0.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.0	GO:0032789	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.2	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.2	GO:0006465	signal peptide processing(GO:0006465)
0.0	0.0	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.0	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.0	GO:0003164	His-Purkinje system development(GO:0003164)
0.0	0.0	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.0	GO:0003175	tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.2	GO:0031954	positive regulation of protein autophosphorylation(GO:0031954)
0.0	0.1	GO:0032482	Rab protein signal transduction(GO:0032482)
0.0	0.0	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.0	GO:1904502	lipophagy(GO:0061724) regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0	0.0	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.0	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.1	GO:0009249	protein lipoylation(GO:0009249)
0.0	0.0	GO:0033092	positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.0	0.1	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.2	GO:0010257	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.1	GO:0071397	cellular response to cholesterol(GO:0071397)
0.0	0.0	GO:0009629	response to gravity(GO:0009629)
0.0	0.0	GO:1901165	positive regulation of trophoblast cell migration(GO:1901165)
0.0	0.1	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.0	0.0	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
0.0	0.1	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.0	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.0	GO:0070340	detection of bacterial lipopeptide(GO:0070340)
0.0	0.0	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.0	GO:0036016	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.0	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.1	GO:0006353	DNA-templated transcription, termination(GO:0006353)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.0	GO:1903899	positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.0	0.1	GO:0097084	vascular smooth muscle cell development(GO:0097084)
0.0	0.1	GO:0060020	Bergmann glial cell differentiation(GO:0060020)
0.0	0.0	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:0042256	mature ribosome assembly(GO:0042256)
0.0	0.0	GO:0043174	nucleoside salvage(GO:0043174)
0.0	0.1	GO:0080154	regulation of fertilization(GO:0080154)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.0	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.0	0.0	GO:0035627	ceramide transport(GO:0035627)
0.0	0.1	GO:0019184	nonribosomal peptide biosynthetic process(GO:0019184)
0.0	0.0	GO:0097212	lysosomal membrane organization(GO:0097212)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:0097504	Gemini of coiled bodies(GO:0097504)
0.0	0.3	GO:0016342	catenin complex(GO:0016342)
0.0	0.2	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0032437	cuticular plate(GO:0032437)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.2	GO:0070852	cell body fiber(GO:0070852)
0.0	0.0	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306)
0.0	0.2	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.2	GO:0097208	alveolar lamellar body(GO:0097208)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.1	GO:0031211	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.0	GO:0044611	nuclear pore inner ring(GO:0044611)
0.0	0.1	GO:0032797	SMN complex(GO:0032797)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.0	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	0.1	GO:0033263	CORVET complex(GO:0033263)
0.0	0.2	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.1	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.0	0.1	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.0	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0030897	HOPS complex(GO:0030897)
0.0	0.0	GO:0031595	nuclear proteasome complex(GO:0031595)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0072669	tRNA-splicing ligase complex(GO:0072669)
0.0	0.0	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.0	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.0	GO:0072588	box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0	0.1	GO:0045261	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.2	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.0	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0	0.0	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.0	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.0	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.0	0.1	GO:0036128	CatSper complex(GO:0036128)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0008540	proteasome regulatory particle, base subcomplex(GO:0008540)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0004771	sterol esterase activity(GO:0004771)
0.1	0.3	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	0.3	GO:0034056	estrogen response element binding(GO:0034056)
0.1	0.3	GO:0004075	biotin carboxylase activity(GO:0004075)
0.1	0.2	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.0	GO:0050051	leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.0	0.1	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.1	GO:0034191	apolipoprotein A-I receptor binding(GO:0034191)
0.0	0.1	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0004096	catalase activity(GO:0004096)
0.0	0.2	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0070087	chromo shadow domain binding(GO:0070087)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0004083	bisphosphoglycerate 2-phosphatase activity(GO:0004083)
0.0	0.2	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.1	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0033695	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.2	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.1	GO:0030620	U2 snRNA binding(GO:0030620)
0.0	0.3	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.3	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0018633	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) phenanthrene 9,10-monooxygenase activity(GO:0018636) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.6	GO:0080031	prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.1	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.1	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.0	GO:1990050	phosphatidic acid transporter activity(GO:1990050)
0.0	0.3	GO:0005528	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0034548	N-cyclopropylmelamine deaminase activity(GO:0034547) N-cyclopropylammeline deaminase activity(GO:0034548) N-cyclopropylammelide alkylamino hydrolase activity(GO:0034549) 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity(GO:0043723) tRNA-specific adenosine-37 deaminase activity(GO:0043829) archaeal-specific GTP cyclohydrolase activity(GO:0044682) tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.0	0.2	GO:0070402	NADPH binding(GO:0070402)
0.0	0.0	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.0	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0072542	protein phosphatase activator activity(GO:0072542)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.0	GO:0008332	low voltage-gated calcium channel activity(GO:0008332)
0.0	0.1	GO:0070679	inositol 1,4,5 trisphosphate binding(GO:0070679)
0.0	0.1	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
0.0	0.0	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0098821	BMP receptor activity(GO:0098821)
0.0	0.1	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.1	GO:0070410	co-SMAD binding(GO:0070410)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.0	GO:0001602	pancreatic polypeptide receptor activity(GO:0001602)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.0	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.0	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.0	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.0	GO:0005375	copper ion transmembrane transporter activity(GO:0005375)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.0	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.0	0.3	GO:0030552	cAMP binding(GO:0030552)
0.0	0.4	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.0	0.1	GO:0097602	cullin family protein binding(GO:0097602)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.0	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.0	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.1	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.0	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.0	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0	0.3	GO:0017134	fibroblast growth factor binding(GO:0017134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.4	PID ALK1 PATHWAY	ALK1 signaling events
0.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.1	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	PID AVB3 INTEGRIN PATHWAY	Integrins in angiogenesis

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.3	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.2	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.4	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.2	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.3	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.1	REACTOME CTNNB1 PHOSPHORYLATION CASCADE	Genes involved in Beta-catenin phosphorylation cascade
0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.1	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.2	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins