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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hoxb4

Z-value: 1.55

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Transcription factors associated with Hoxb4

Gene Symbol	Gene ID	Gene Info
Hoxb4 Ensembl NCBI MGI UniProt	ENSMUSG00000038692.7	Hoxb4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hoxb4	chr11_96318577_96318760	401	0.605874	0.53	2.8e-01	Click!

Activity of the Hoxb4 motif across conditions

Conditions sorted by the z-value of the Hoxb4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr7_126260333_126260533	0.98	Sbk1	SH3-binding kinase 1	11571	0.11
chr6_144895556_144895729	0.94	Gm22792	predicted gene, 22792	92010	0.07
chr11_16866408_16866907	0.92	Egfr	epidermal growth factor receptor	11493	0.2
chr1_162986828_162987029	0.91	Fmo3	flavin containing monooxygenase 3	2400	0.25
chr7_140767632_140767811	0.91	Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	3240	0.12
chr18_62224841_62225012	0.81	Gm9949	predicted gene 9949	44800	0.14
chr14_74794292_74794475	0.81	Lrch1	leucine-rich repeats and calponin homology (CH) domain containing 1	608	0.79
chr11_16882054_16882234	0.80	Egfr	epidermal growth factor receptor	3994	0.24
chr12_69759378_69759543	0.74	Mir681	microRNA 681	4484	0.15
chr2_75564827_75565114	0.71	Gm13655	predicted gene 13655	68412	0.08
chr12_35573403_35573591	0.71	Gm48237	predicted gene, 48237	27466	0.14
chr13_52150386_52150766	0.71	Gm48199	predicted gene, 48199	29835	0.18
chr18_31771523_31771682	0.70	Ammecr1l	AMME chromosomal region gene 1-like	9798	0.13
chr13_109881168_109881343	0.67	Pde4d	phosphodiesterase 4D, cAMP specific	21847	0.23
chr19_21919301_21919474	0.66	Ldhb-ps	lactate dehydrogenase B, pseudogene	17993	0.18
chr13_80895235_80895839	0.62	Arrdc3	arrestin domain containing 3	5019	0.18
chr10_95354659_95354831	0.61	2310039L15Rik	RIKEN cDNA 2310039L15 gene	143	0.94
chr4_139875950_139876108	0.60	Gm1667	predicted gene 1667	34459	0.13
chr6_51700821_51700988	0.60	Gm38811	predicted gene, 38811	10177	0.25
chr2_72306157_72306335	0.60	Map3k20	mitogen-activated protein kinase kinase kinase 20	8345	0.2
chr10_60933932_60934087	0.57	Gm26947	predicted gene, 26947	2018	0.24
chr9_74886235_74886449	0.54	Onecut1	one cut domain, family member 1	19858	0.14
chr9_13681735_13681905	0.53	Maml2	mastermind like transcriptional coactivator 2	19360	0.18
chr2_13484483_13484816	0.53	Cubn	cubilin (intrinsic factor-cobalamin receptor)	7164	0.26
chr11_79753212_79753391	0.53	Mir365-2	microRNA 365-2	26901	0.12
chr9_83254483_83254659	0.52	Gm27216	predicted gene 27216	31	0.98
chr1_71938584_71938854	0.51	Gm28818	predicted gene 28818	21594	0.17
chr10_99314465_99314820	0.51	B530045E10Rik	RIKEN cDNA B530045E10 gene	15476	0.14
chr4_111200292_111200482	0.51	Agbl4	ATP/GTP binding protein-like 4	81476	0.1
chr8_40858142_40858306	0.50	Gm5345	predicted gene 5345	3197	0.19
chr6_33958384_33958553	0.49	Gm13853	predicted gene 13853	33943	0.19
chr1_181307865_181308016	0.48	Gm8146	predicted gene 8146	25894	0.14
chr7_77888814_77888965	0.48	Gm23239	predicted gene, 23239	21431	0.28
chr3_116969952_116970108	0.46	Palmd	palmdelphin	1043	0.39
chr5_45534505_45534782	0.46	Fam184b	family with sequence similarity 184, member B	1899	0.22
chr15_30285783_30285996	0.45	Ctnnd2	catenin (cadherin associated protein), delta 2	112751	0.06
chr13_64388507_64388698	0.45	Ctsl	cathepsin L	17712	0.1
chr5_145800258_145800417	0.45	Cyp3a44	cytochrome P450, family 3, subfamily a, polypeptide 44	5537	0.18
chr4_7195720_7195887	0.44	Gm11804	predicted gene 11804	156289	0.04
chr18_55107121_55107272	0.43	AC163347.1	novel transcript	10836	0.17
chr2_146099387_146099651	0.42	Cfap61	cilia and flagella associated protein 61	52268	0.15
chr12_114053283_114053753	0.42	Ighv3-2	immunoglobulin heavy variable 3-2	19285	0.13
chr15_77153726_77153986	0.42	Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	44	0.97
chr1_43066043_43066369	0.41	Tgfbrap1	transforming growth factor, beta receptor associated protein 1	5273	0.14
chr6_6279071_6279331	0.41	Gm20619	predicted gene 20619	20220	0.18
chr12_15816769_15817061	0.40	Trib2	tribbles pseudokinase 2	7	0.56
chr9_110676644_110676946	0.40	Gm35715	predicted gene, 35715	1841	0.21
chr15_10713141_10713319	0.39	Rai14	retinoic acid induced 14	310	0.87
chr1_9967919_9968070	0.39	Tcf24	transcription factor 24	62	0.9
chr2_92380520_92380699	0.38	1700029I15Rik	RIKEN cDNA 1700029I15 gene	1929	0.18
chr11_101669101_101669273	0.38	Arl4d	ADP-ribosylation factor-like 4D	3646	0.12
chr10_28524334_28524485	0.38	Ptprk	protein tyrosine phosphatase, receptor type, K	35742	0.22
chr2_78049569_78049722	0.37	4930440I19Rik	RIKEN cDNA 4930440I19 gene	1532	0.51
chr2_163670938_163671176	0.37	Pkig	protein kinase inhibitor, gamma	9558	0.13
chr6_116650512_116650679	0.37	Depp1	DEPP1 autophagy regulator	14	0.95
chr14_57107497_57107648	0.37	Gjb2	gap junction protein, beta 2	2870	0.2
chr10_95942046_95942222	0.37	Eea1	early endosome antigen 1	1377	0.41
chr13_101866951_101867131	0.36	Gm47007	predicted gene, 47007	11550	0.2
chr9_116091537_116091709	0.36	Gm9385	predicted pseudogene 9385	50559	0.13
chr11_6021664_6021840	0.35	Camk2b	calcium/calmodulin-dependent protein kinase II, beta	21304	0.15
chr8_35920405_35920556	0.35	5430403N17Rik	RIKEN cDNA 5430403N17 gene	37523	0.14
chr18_74805142_74805295	0.35	Acaa2	acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)	11835	0.15
chr2_26477777_26477967	0.35	Notch1	notch 1	7374	0.1
chr19_43971247_43971535	0.35	Cpn1	carboxypeptidase N, polypeptide 1	2698	0.21
chr4_97960846_97961009	0.35	Nfia	nuclear factor I/A	49894	0.17
chr14_18236888_18237050	0.35	Nr1d2	nuclear receptor subfamily 1, group D, member 2	2042	0.24
chr10_127632738_127633305	0.35	Gm48815	predicted gene, 48815	3366	0.11
chr12_113987570_113987864	0.35	Gm37961	predicted gene, 37961	18865	0.14
chr6_95684732_95684897	0.35	Suclg2	succinate-Coenzyme A ligase, GDP-forming, beta subunit	8068	0.32
chrX_166678508_166678678	0.35	Gm1720	predicted gene 1720	16568	0.21
chr9_94692147_94692428	0.35	Gm16262	predicted gene 16262	10032	0.17
chr3_57435613_57435790	0.34	Tm4sf4	transmembrane 4 superfamily member 4	10387	0.22
chr16_5662022_5662331	0.34	Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	223179	0.02
chr19_42631725_42631876	0.34	Loxl4	lysyl oxidase-like 4	18987	0.18
chr6_29538799_29539193	0.34	Irf5	interferon regulatory factor 5	2150	0.2
chr16_36545463_36545634	0.33	Casr	calcium-sensing receptor	16058	0.11
chr2_169390357_169390514	0.33	Gm14250	predicted gene 14250	1354	0.49
chr3_101504490_101504690	0.33	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	72970	0.07
chr19_47886740_47886936	0.32	Gsto2	glutathione S-transferase omega 2	16576	0.13
chr2_160702528_160702695	0.32	Top1	topoisomerase (DNA) I	468	0.81
chr15_59055272_59055945	0.32	Mtss1	MTSS I-BAR domain containing 1	144	0.97
chr6_101102390_101102554	0.32	Gm43942	predicted gene, 43942	41820	0.12
chr17_84082154_84082324	0.31	4933433H22Rik	RIKEN cDNA 4933433H22 gene	3579	0.19
chr8_88863011_88863356	0.31	Gm45504	predicted gene 45504	109	0.98
chr9_69442354_69442630	0.31	Gm18587	predicted gene, 18587	2471	0.17
chr17_31295551_31296040	0.31	Slc37a1	solute carrier family 37 (glycerol-3-phosphate transporter), member 1	31	0.94
chr14_118635288_118635751	0.31	Abcc4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	41412	0.12
chr3_107943742_107943913	0.31	Gstm6	glutathione S-transferase, mu 6	78	0.92
chr19_32190045_32190211	0.31	Sgms1	sphingomyelin synthase 1	6300	0.24
chr6_37537920_37538092	0.30	Akr1d1	aldo-keto reductase family 1, member D1	1675	0.4
chr11_49247308_49247488	0.30	Mgat1	mannoside acetylglucosaminyltransferase 1	79	0.95
chr10_51453986_51454193	0.29	Gm46189	predicted gene, 46189	1891	0.26
chr9_58105721_58106037	0.29	Ccdc33	coiled-coil domain containing 33	3582	0.17
chr10_110927526_110927725	0.29	Csrp2	cysteine and glycine-rich protein 2	3576	0.19
chr12_77045836_77046012	0.28	Gm35189	predicted gene, 35189	3723	0.26
chr6_148199306_148199711	0.28	Ergic2	ERGIC and golgi 2	2980	0.22
chr4_88546855_88547012	0.28	Ifna15	interferon alpha 15	11312	0.1
chr13_9445564_9445785	0.28	Gm48871	predicted gene, 48871	226	0.93
chr17_78379801_78380005	0.28	Fez2	fasciculation and elongation protein zeta 2 (zygin II)	21527	0.15
chr6_142422023_142422193	0.28	Gys2	glycogen synthase 2	1511	0.33
chr10_68868968_68869160	0.28	1700048P04Rik	RIKEN cDNA 1700048P04 gene	35436	0.21
chr13_34242299_34242490	0.27	Slc22a23	solute carrier family 22, member 23	48863	0.11
chr11_61092676_61092849	0.27	Kcnj12	potassium inwardly-rectifying channel, subfamily J, member 12	26958	0.13
chr14_27102040_27102293	0.27	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	12733	0.19
chr18_80258103_80258267	0.27	Slc66a2	solute carrier family 66 member 2	1867	0.22
chr4_40823217_40823652	0.26	Mir5123	microRNA 5123	26704	0.09
chr2_60878102_60878265	0.26	Rbms1	RNA binding motif, single stranded interacting protein 1	3255	0.35
chr4_34551560_34551735	0.26	Akirin2	akirin 2	696	0.68
chr16_25877460_25877655	0.26	Trp63	transformation related protein 63	75641	0.1
chr17_48039561_48039744	0.26	1700122O11Rik	RIKEN cDNA 1700122O11 gene	1359	0.33
chr8_22414456_22414613	0.26	Mrps31	mitochondrial ribosomal protein S31	3136	0.13
chr10_66631116_66631267	0.26	Gm28139	predicted gene 28139	9727	0.22
chr12_84043890_84044041	0.25	Acot4	acyl-CoA thioesterase 4	1416	0.21
chr7_89423273_89423442	0.25	AI314278	expressed sequence AI314278	2949	0.2
chr4_3696728_3696981	0.25	Lyn	LYN proto-oncogene, Src family tyrosine kinase	18724	0.14
chr9_63613110_63613389	0.25	Aagab	alpha- and gamma-adaptin binding protein	3739	0.23
chr8_91657490_91657652	0.25	Gm45295	predicted gene 45295	14326	0.12
chr9_102726405_102726576	0.25	Amotl2	angiomotin-like 2	1841	0.24
chrX_60362413_60362564	0.25	Mir505	microRNA 505	32004	0.17
chr8_25769504_25769685	0.25	Bag4	BCL2-associated athanogene 4	7988	0.1
chr12_54205848_54206011	0.25	Egln3	egl-9 family hypoxia-inducible factor 3	2069	0.28
chr6_142668760_142668977	0.24	Abcc9	ATP-binding cassette, sub-family C (CFTR/MRP), member 9	33350	0.16
chr15_55317395_55317627	0.24	Col14a1	collagen, type XIV, alpha 1	9592	0.24
chr1_10993153_10993537	0.24	Prex2	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2	120	0.98
chr18_84084702_84084863	0.24	Tshz1	teashirt zinc finger family member 1	293	0.88
chr11_106486200_106486366	0.24	Ern1	endoplasmic reticulum (ER) to nucleus signalling 1	1513	0.34
chr14_105253933_105254092	0.24	Gm22290	predicted gene, 22290	4002	0.17
chr2_53063355_53063523	0.24	Prpf40a	pre-mRNA processing factor 40A	81870	0.1
chr19_37648111_37648271	0.24	Cyp26c1	cytochrome P450, family 26, subfamily c, polypeptide 1	37390	0.14
chr8_114117394_114117594	0.24	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	16063	0.27
chr1_31094891_31095067	0.24	4931428L18Rik	RIKEN cDNA 4931428L18 gene	1475	0.35
chr6_115884148_115884359	0.23	Ift122	intraflagellar transport 122	1655	0.26
chr10_125327017_125327436	0.23	Slc16a7	solute carrier family 16 (monocarboxylic acid transporters), member 7	1309	0.51
chr7_137697020_137697186	0.23	Gm45682	predicted gene 45682	37163	0.18
chr1_191254506_191254830	0.23	Gm37074	predicted gene, 37074	5244	0.15
chr19_12719350_12719546	0.23	Gm15962	predicted gene 15962	1755	0.22
chr7_71370855_71371052	0.23	Gm29328	predicted gene 29328	620	0.73
chr3_52338842_52339028	0.22	Gm38034	predicted gene, 38034	56694	0.1
chr7_81250438_81250962	0.22	Gm7180	predicted pseudogene 7180	27826	0.13
chr2_169634592_169634925	0.22	Tshz2	teashirt zinc finger family member 2	1082	0.55
chr17_86470447_86470748	0.22	Prkce	protein kinase C, epsilon	19965	0.22
chr3_101430547_101430727	0.22	Gm42538	predicted gene 42538	3701	0.2
chr7_25987036_25987409	0.22	Gm45225	predicted gene 45225	5720	0.14
chr4_124704877_124705041	0.22	Fhl3	four and a half LIM domains 3	4239	0.1
chr4_60591701_60591858	0.22	Mup-ps5	major urinary protein, pseudogene 5	5818	0.16
chr11_98784049_98784205	0.22	Nr1d1	nuclear receptor subfamily 1, group D, member 1	8794	0.1
chr12_3867079_3867237	0.22	Dnmt3a	DNA methyltransferase 3A	967	0.52
chr6_67102942_67103110	0.22	A430010J10Rik	RIKEN cDNA A430010J10 gene	12647	0.15
chr11_16842718_16842956	0.22	Egfros	epidermal growth factor receptor, opposite strand	12135	0.2
chr4_118123096_118123255	0.22	St3gal3	ST3 beta-galactoside alpha-2,3-sialyltransferase 3	11707	0.16
chr6_145855503_145855668	0.22	Gm43909	predicted gene, 43909	7712	0.17
chr16_34322645_34322806	0.22	Kalrn	kalirin, RhoGEF kinase	39074	0.22
chr11_23101055_23101224	0.21	Gm12059	predicted gene 12059	33141	0.12
chr12_118792020_118792190	0.21	Gm6171	predicted gene 6171	1727	0.38
chr13_81368031_81368195	0.21	Adgrv1	adhesion G protein-coupled receptor V1	16487	0.26
chr13_4143590_4143758	0.21	Akr1c18	aldo-keto reductase family 1, member C18	6954	0.13
chr11_79305709_79305885	0.21	Gm9964	predicted gene 9964	8891	0.16
chr11_106268502_106268656	0.21	Smarcd2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2	780	0.42
chr6_27967716_27967883	0.21	Mir592	microRNA 592	31049	0.23
chr14_69729701_69729901	0.21	Chmp7	charged multivesicular body protein 7	1074	0.4
chr13_115090695_115090877	0.21	Pelo	pelota mRNA surveillance and ribosome rescue factor	600	0.58
chr1_138510594_138510753	0.20	Gm28501	predicted gene 28501	4942	0.23
chr9_78149872_78150023	0.20	Cilk1	ciliogenesis associated kinase 1	5376	0.13
chr11_22893094_22893344	0.20	Gm24917	predicted gene, 24917	24318	0.11
chr2_102706025_102706412	0.20	Slc1a2	solute carrier family 1 (glial high affinity glutamate transporter), member 2	138	0.97
chr12_79642030_79642203	0.20	9430078K24Rik	RIKEN cDNA 9430078K24 gene	282617	0.01
chr4_60149368_60149527	0.20	Mup2	major urinary protein 2	4842	0.19
chr3_97631636_97631799	0.20	Fmo5	flavin containing monooxygenase 5	2834	0.19
chr4_60299101_60299261	0.20	Mup-ps3	major urinary protein, pseudogene 3	61836	0.09
chr5_63936466_63936784	0.20	Rell1	RELT-like 1	5711	0.18
chr17_35242702_35242853	0.20	Gm22589	predicted gene, 22589	99	0.48
chr11_16894642_16894943	0.20	Egfr	epidermal growth factor receptor	10393	0.2
chr5_130024306_130024463	0.20	Asl	argininosuccinate lyase	3	0.96
chr4_60231470_60231627	0.20	Mup-ps3	major urinary protein, pseudogene 3	5797	0.2
chr2_24839386_24839554	0.20	Ehmt1	euchromatic histone methyltransferase 1	121	0.95
chr12_73408646_73408959	0.19	D830013O20Rik	RIKEN cDNA D830013O20 gene	755	0.63
chr14_11569795_11569971	0.19	Ptprg	protein tyrosine phosphatase, receptor type, G	16302	0.21
chr13_104035617_104035778	0.19	Nln	neurolysin (metallopeptidase M3 family)	870	0.63
chr3_95901553_95901705	0.19	Car14	carbonic anhydrase 14	2119	0.14
chr4_144957116_144957269	0.19	Gm38074	predicted gene, 38074	1656	0.38
chr16_62881474_62881642	0.19	Pros1	protein S (alpha)	16591	0.19
chr1_21228840_21229005	0.19	Gm38224	predicted gene, 38224	5800	0.13
chr8_10439826_10440109	0.19	Myo16	myosin XVI	167395	0.03
chr7_99170677_99170840	0.19	Dgat2	diacylglycerol O-acyltransferase 2	652	0.61
chr12_76431059_76431246	0.19	Ppp1r36	protein phosphatase 1, regulatory subunit 36	4561	0.12
chr4_61844883_61845043	0.19	Mup5	major urinary protein 5	9730	0.12
chr4_148616208_148616450	0.19	Tardbp	TAR DNA binding protein	191	0.9
chr19_34745215_34745404	0.19	Slc16a12	solute carrier family 16 (monocarboxylic acid transporters), member 12	1980	0.23
chr4_61312938_61313093	0.19	Mup-ps11	major urinary protein, pseudogene 11	5715	0.2
chr16_70352273_70352442	0.19	Gbe1	glucan (1,4-alpha-), branching enzyme 1	38223	0.19
chr16_13159523_13159853	0.19	Ercc4	excision repair cross-complementing rodent repair deficiency, complementation group 4	27297	0.22
chr18_24054985_24055136	0.19	Gm18085	predicted gene, 18085	26864	0.14
chr9_57723131_57723308	0.19	Edc3	enhancer of mRNA decapping 3	14652	0.12
chr8_128350486_128350652	0.19	Nrp1	neuropilin 1	8035	0.23
chr9_99353176_99353333	0.19	Esyt3	extended synaptotagmin-like protein 3	5264	0.13
chr13_99667017_99667216	0.18	1700012J22Rik	RIKEN cDNA 1700012J22 gene	25142	0.18
chr1_176982464_176982654	0.18	Gm37519	predicted gene, 37519	8323	0.15
chr5_31199891_31200213	0.18	Zfp513	zinc finger protein 513	234	0.8
chr2_64093669_64093820	0.18	Fign	fidgetin	4244	0.37
chr17_84269883_84270034	0.18	Gm24492	predicted gene, 24492	17789	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.4	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.1	0.3	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.2	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1	0.2	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.1	0.1	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1	0.3	GO:0015712	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1	0.2	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.2	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.2	GO:0060023	soft palate development(GO:0060023)
0.0	0.1	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.0	0.1	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0002086	diaphragm contraction(GO:0002086)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.3	GO:0006265	DNA topological change(GO:0006265)
0.0	0.3	GO:0060613	fat pad development(GO:0060613)
0.0	0.3	GO:0018026	peptidyl-lysine monomethylation(GO:0018026)
0.0	0.2	GO:0071763	nuclear membrane organization(GO:0071763)
0.0	0.1	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:0032789	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.1	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.3	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.1	GO:2000002	negative regulation of DNA damage checkpoint(GO:2000002)
0.0	0.1	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.0	0.1	GO:0003241	growth involved in heart morphogenesis(GO:0003241)
0.0	0.1	GO:0015819	lysine transport(GO:0015819)
0.0	0.1	GO:0032914	positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0	0.0	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.1	GO:0016103	diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.4	GO:0017144	drug metabolic process(GO:0017144)
0.0	0.1	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0	0.1	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.0	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.0	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.0	0.0	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.0	GO:1900825	regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0	0.1	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0	0.0	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.0	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187)
0.0	0.0	GO:0021886	cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) sensory neuron axon guidance(GO:0097374) facioacoustic ganglion development(GO:1903375)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.0	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.0	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.1	GO:0009597	detection of virus(GO:0009597)
0.0	0.1	GO:0090427	activation of meiosis(GO:0090427)
0.0	0.1	GO:0002513	tolerance induction to self antigen(GO:0002513)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0014816	skeletal muscle satellite cell differentiation(GO:0014816)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	0.0	GO:0035771	interleukin-4-mediated signaling pathway(GO:0035771)
0.0	0.0	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.0	GO:0016115	terpenoid catabolic process(GO:0016115)
0.0	0.0	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.0	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.0	GO:0021943	formation of radial glial scaffolds(GO:0021943)
0.0	0.0	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.0	GO:0046864	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0	0.0	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.3	GO:0001651	dense fibrillar component(GO:0001651)
0.0	0.1	GO:0044308	axonal spine(GO:0044308)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0	0.2	GO:0070852	cell body fiber(GO:0070852)
0.0	0.0	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.0	0.1	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0005688	U6 snRNP(GO:0005688)
0.0	0.0	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.0	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.1	GO:0002177	manchette(GO:0002177)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.3	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1	0.2	GO:0016842	amidine-lyase activity(GO:0016842)
0.1	0.3	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.1	0.2	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.1	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.3	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0004939	beta-adrenergic receptor activity(GO:0004939)
0.0	0.1	GO:0030621	U4 snRNA binding(GO:0030621)
0.0	0.1	GO:0035671	enone reductase activity(GO:0035671)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0008401	retinoic acid 4-hydroxylase activity(GO:0008401)
0.0	0.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.4	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.5	GO:0004364	glutathione transferase activity(GO:0004364)
0.0	0.2	GO:0055106	ubiquitin-protein transferase regulator activity(GO:0055106)
0.0	0.0	GO:0004487	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0	0.1	GO:0034802	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.0	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.0	GO:0051032	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.0	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.0	GO:0030984	kininogen binding(GO:0030984)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.0	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.5	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.1	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters