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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for Hoxb4

Z-value: 1.55

Motif logo

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Transcription factors associated with Hoxb4

Gene Symbol Gene ID Gene Info
Hoxb4
ENSMUSG00000038692.7 homeobox B4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr11_96318577_96318760Hoxb44010.6058740.532.8e-01Click!

Activity of the Hoxb4 motif across conditions

Conditions sorted by the z-value of the Hoxb4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr7_126260333_126260533 0.98 Sbk1
 SH3-binding kinase 1
 11571
 0.11
chr6_144895556_144895729 0.94 Gm22792
 predicted gene, 22792
 92010
 0.07
chr11_16866408_16866907 0.92 Egfr
 epidermal growth factor receptor
 11493
 0.2
chr1_162986828_162987029 0.91 Fmo3
 flavin containing monooxygenase 3
 2400
 0.25
chr7_140767632_140767811 0.91 Cyp2e1
 cytochrome P450, family 2, subfamily e, polypeptide 1
 3240
 0.12
chr18_62224841_62225012 0.81 Gm9949
 predicted gene 9949
 44800
 0.14
chr14_74794292_74794475 0.81 Lrch1
 leucine-rich repeats and calponin homology (CH) domain containing 1
 608
 0.79
chr11_16882054_16882234 0.80 Egfr
 epidermal growth factor receptor
 3994
 0.24
chr12_69759378_69759543 0.74 Mir681
 microRNA 681
 4484
 0.15
chr2_75564827_75565114 0.71 Gm13655
 predicted gene 13655
 68412
 0.08
chr12_35573403_35573591 0.71 Gm48237
 predicted gene, 48237
 27466
 0.14
chr13_52150386_52150766 0.71 Gm48199
 predicted gene, 48199
 29835
 0.18
chr18_31771523_31771682 0.70 Ammecr1l
 AMME chromosomal region gene 1-like
 9798
 0.13
chr13_109881168_109881343 0.67 Pde4d
 phosphodiesterase 4D, cAMP specific
 21847
 0.23
chr19_21919301_21919474 0.66 Ldhb-ps
 lactate dehydrogenase B, pseudogene
 17993
 0.18
chr13_80895235_80895839 0.62 Arrdc3
 arrestin domain containing 3
 5019
 0.18
chr10_95354659_95354831 0.61 2310039L15Rik
 RIKEN cDNA 2310039L15 gene
 143
 0.94
chr4_139875950_139876108 0.60 Gm1667
 predicted gene 1667
 34459
 0.13
chr6_51700821_51700988 0.60 Gm38811
 predicted gene, 38811
 10177
 0.25
chr2_72306157_72306335 0.60 Map3k20
 mitogen-activated protein kinase kinase kinase 20
 8345
 0.2
chr10_60933932_60934087 0.57 Gm26947
 predicted gene, 26947
 2018
 0.24
chr9_74886235_74886449 0.54 Onecut1
 one cut domain, family member 1
 19858
 0.14
chr9_13681735_13681905 0.53 Maml2
 mastermind like transcriptional coactivator 2
 19360
 0.18
chr2_13484483_13484816 0.53 Cubn
 cubilin (intrinsic factor-cobalamin receptor)
 7164
 0.26
chr11_79753212_79753391 0.53 Mir365-2
 microRNA 365-2
 26901
 0.12
chr9_83254483_83254659 0.52 Gm27216
 predicted gene 27216
 31
 0.98
chr1_71938584_71938854 0.51 Gm28818
 predicted gene 28818
 21594
 0.17
chr10_99314465_99314820 0.51 B530045E10Rik
 RIKEN cDNA B530045E10 gene
 15476
 0.14
chr4_111200292_111200482 0.51 Agbl4
 ATP/GTP binding protein-like 4
 81476
 0.1
chr8_40858142_40858306 0.50 Gm5345
 predicted gene 5345
 3197
 0.19
chr6_33958384_33958553 0.49 Gm13853
 predicted gene 13853
 33943
 0.19
chr1_181307865_181308016 0.48 Gm8146
 predicted gene 8146
 25894
 0.14
chr7_77888814_77888965 0.48 Gm23239
 predicted gene, 23239
 21431
 0.28
chr3_116969952_116970108 0.46 Palmd
 palmdelphin
 1043
 0.39
chr5_45534505_45534782 0.46 Fam184b
 family with sequence similarity 184, member B
 1899
 0.22
chr15_30285783_30285996 0.45 Ctnnd2
 catenin (cadherin associated protein), delta 2
 112751
 0.06
chr13_64388507_64388698 0.45 Ctsl
 cathepsin L
 17712
 0.1
chr5_145800258_145800417 0.45 Cyp3a44
 cytochrome P450, family 3, subfamily a, polypeptide 44
 5537
 0.18
chr4_7195720_7195887 0.44 Gm11804
 predicted gene 11804
 156289
 0.04
chr18_55107121_55107272 0.43 AC163347.1
 novel transcript
 10836
 0.17
chr2_146099387_146099651 0.42 Cfap61
 cilia and flagella associated protein 61
 52268
 0.15
chr12_114053283_114053753 0.42 Ighv3-2
 immunoglobulin heavy variable 3-2
 19285
 0.13
chr15_77153726_77153986 0.42 Rbfox2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 44
 0.97
chr1_43066043_43066369 0.41 Tgfbrap1
 transforming growth factor, beta receptor associated protein 1
 5273
 0.14
chr6_6279071_6279331 0.41 Gm20619
 predicted gene 20619
 20220
 0.18
chr12_15816769_15817061 0.40 Trib2
 tribbles pseudokinase 2
 7
 0.56
chr9_110676644_110676946 0.40 Gm35715
 predicted gene, 35715
 1841
 0.21
chr15_10713141_10713319 0.39 Rai14
 retinoic acid induced 14
 310
 0.87
chr1_9967919_9968070 0.39 Tcf24
 transcription factor 24
 62
 0.9
chr2_92380520_92380699 0.38 1700029I15Rik
 RIKEN cDNA 1700029I15 gene
 1929
 0.18
chr11_101669101_101669273 0.38 Arl4d
 ADP-ribosylation factor-like 4D
 3646
 0.12
chr10_28524334_28524485 0.38 Ptprk
 protein tyrosine phosphatase, receptor type, K
 35742
 0.22
chr2_78049569_78049722 0.37 4930440I19Rik
 RIKEN cDNA 4930440I19 gene
 1532
 0.51
chr2_163670938_163671176 0.37 Pkig
 protein kinase inhibitor, gamma
 9558
 0.13
chr6_116650512_116650679 0.37 Depp1
 DEPP1 autophagy regulator
 14
 0.95
chr14_57107497_57107648 0.37 Gjb2
 gap junction protein, beta 2
 2870
 0.2
chr10_95942046_95942222 0.37 Eea1
 early endosome antigen 1
 1377
 0.41
chr13_101866951_101867131 0.36 Gm47007
 predicted gene, 47007
 11550
 0.2
chr9_116091537_116091709 0.36 Gm9385
 predicted pseudogene 9385
 50559
 0.13
chr11_6021664_6021840 0.35 Camk2b
 calcium/calmodulin-dependent protein kinase II, beta
 21304
 0.15
chr8_35920405_35920556 0.35 5430403N17Rik
 RIKEN cDNA 5430403N17 gene
 37523
 0.14
chr18_74805142_74805295 0.35 Acaa2
 acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
 11835
 0.15
chr2_26477777_26477967 0.35 Notch1
 notch 1
 7374
 0.1
chr19_43971247_43971535 0.35 Cpn1
 carboxypeptidase N, polypeptide 1
 2698
 0.21
chr4_97960846_97961009 0.35 Nfia
 nuclear factor I/A
 49894
 0.17
chr14_18236888_18237050 0.35 Nr1d2
 nuclear receptor subfamily 1, group D, member 2
 2042
 0.24
chr10_127632738_127633305 0.35 Gm48815
 predicted gene, 48815
 3366
 0.11
chr12_113987570_113987864 0.35 Gm37961
 predicted gene, 37961
 18865
 0.14
chr6_95684732_95684897 0.35 Suclg2
 succinate-Coenzyme A ligase, GDP-forming, beta subunit
 8068
 0.32
chrX_166678508_166678678 0.35 Gm1720
 predicted gene 1720
 16568
 0.21
chr9_94692147_94692428 0.35 Gm16262
 predicted gene 16262
 10032
 0.17
chr3_57435613_57435790 0.34 Tm4sf4
 transmembrane 4 superfamily member 4
 10387
 0.22
chr16_5662022_5662331 0.34 Rbfox1
 RNA binding protein, fox-1 homolog (C. elegans) 1
 223179
 0.02
chr19_42631725_42631876 0.34 Loxl4
 lysyl oxidase-like 4
 18987
 0.18
chr6_29538799_29539193 0.34 Irf5
 interferon regulatory factor 5
 2150
 0.2
chr16_36545463_36545634 0.33 Casr
 calcium-sensing receptor
 16058
 0.11
chr2_169390357_169390514 0.33 Gm14250
 predicted gene 14250
 1354
 0.49
chr3_101504490_101504690 0.33 Atp1a1
 ATPase, Na+/K+ transporting, alpha 1 polypeptide
 72970
 0.07
chr19_47886740_47886936 0.32 Gsto2
 glutathione S-transferase omega 2
 16576
 0.13
chr2_160702528_160702695 0.32 Top1
 topoisomerase (DNA) I
 468
 0.81
chr15_59055272_59055945 0.32 Mtss1
 MTSS I-BAR domain containing 1
 144
 0.97
chr6_101102390_101102554 0.32 Gm43942
 predicted gene, 43942
 41820
 0.12
chr17_84082154_84082324 0.31 4933433H22Rik
 RIKEN cDNA 4933433H22 gene
 3579
 0.19
chr8_88863011_88863356 0.31 Gm45504
 predicted gene 45504
 109
 0.98
chr9_69442354_69442630 0.31 Gm18587
 predicted gene, 18587
 2471
 0.17
chr17_31295551_31296040 0.31 Slc37a1
 solute carrier family 37 (glycerol-3-phosphate transporter), member 1
 31
 0.94
chr14_118635288_118635751 0.31 Abcc4
 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
 41412
 0.12
chr3_107943742_107943913 0.31 Gstm6
 glutathione S-transferase, mu 6
 78
 0.92
chr19_32190045_32190211 0.31 Sgms1
 sphingomyelin synthase 1
 6300
 0.24
chr6_37537920_37538092 0.30 Akr1d1
 aldo-keto reductase family 1, member D1
 1675
 0.4
chr11_49247308_49247488 0.30 Mgat1
 mannoside acetylglucosaminyltransferase 1
 79
 0.95
chr10_51453986_51454193 0.29 Gm46189
 predicted gene, 46189
 1891
 0.26
chr9_58105721_58106037 0.29 Ccdc33
 coiled-coil domain containing 33
 3582
 0.17
chr10_110927526_110927725 0.29 Csrp2
 cysteine and glycine-rich protein 2
 3576
 0.19
chr12_77045836_77046012 0.28 Gm35189
 predicted gene, 35189
 3723
 0.26
chr6_148199306_148199711 0.28 Ergic2
 ERGIC and golgi 2
 2980
 0.22
chr4_88546855_88547012 0.28 Ifna15
 interferon alpha 15
 11312
 0.1
chr13_9445564_9445785 0.28 Gm48871
 predicted gene, 48871
 226
 0.93
chr17_78379801_78380005 0.28 Fez2
 fasciculation and elongation protein zeta 2 (zygin II)
 21527
 0.15
chr6_142422023_142422193 0.28 Gys2
 glycogen synthase 2
 1511
 0.33
chr10_68868968_68869160 0.28 1700048P04Rik
 RIKEN cDNA 1700048P04 gene
 35436
 0.21
chr13_34242299_34242490 0.27 Slc22a23
 solute carrier family 22, member 23
 48863
 0.11
chr11_61092676_61092849 0.27 Kcnj12
 potassium inwardly-rectifying channel, subfamily J, member 12
 26958
 0.13
chr14_27102040_27102293 0.27 Arhgef3
 Rho guanine nucleotide exchange factor (GEF) 3
 12733
 0.19
chr18_80258103_80258267 0.27 Slc66a2
 solute carrier family 66 member 2
 1867
 0.22
chr4_40823217_40823652 0.26 Mir5123
 microRNA 5123
 26704
 0.09
chr2_60878102_60878265 0.26 Rbms1
 RNA binding motif, single stranded interacting protein 1
 3255
 0.35
chr4_34551560_34551735 0.26 Akirin2
 akirin 2
 696
 0.68
chr16_25877460_25877655 0.26 Trp63
 transformation related protein 63
 75641
 0.1
chr17_48039561_48039744 0.26 1700122O11Rik
 RIKEN cDNA 1700122O11 gene
 1359
 0.33
chr8_22414456_22414613 0.26 Mrps31
 mitochondrial ribosomal protein S31
 3136
 0.13
chr10_66631116_66631267 0.26 Gm28139
 predicted gene 28139
 9727
 0.22
chr12_84043890_84044041 0.25 Acot4
 acyl-CoA thioesterase 4
 1416
 0.21
chr7_89423273_89423442 0.25 AI314278
 expressed sequence AI314278
 2949
 0.2
chr4_3696728_3696981 0.25 Lyn
 LYN proto-oncogene, Src family tyrosine kinase
 18724
 0.14
chr9_63613110_63613389 0.25 Aagab
 alpha- and gamma-adaptin binding protein
 3739
 0.23
chr8_91657490_91657652 0.25 Gm45295
 predicted gene 45295
 14326
 0.12
chr9_102726405_102726576 0.25 Amotl2
 angiomotin-like 2
 1841
 0.24
chrX_60362413_60362564 0.25 Mir505
 microRNA 505
 32004
 0.17
chr8_25769504_25769685 0.25 Bag4
 BCL2-associated athanogene 4
 7988
 0.1
chr12_54205848_54206011 0.25 Egln3
 egl-9 family hypoxia-inducible factor 3
 2069
 0.28
chr6_142668760_142668977 0.24 Abcc9
 ATP-binding cassette, sub-family C (CFTR/MRP), member 9
 33350
 0.16
chr15_55317395_55317627 0.24 Col14a1
 collagen, type XIV, alpha 1
 9592
 0.24
chr1_10993153_10993537 0.24 Prex2
 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2
 120
 0.98
chr18_84084702_84084863 0.24 Tshz1
 teashirt zinc finger family member 1
 293
 0.88
chr11_106486200_106486366 0.24 Ern1
 endoplasmic reticulum (ER) to nucleus signalling 1
 1513
 0.34
chr14_105253933_105254092 0.24 Gm22290
 predicted gene, 22290
 4002
 0.17
chr2_53063355_53063523 0.24 Prpf40a
 pre-mRNA processing factor 40A
 81870
 0.1
chr19_37648111_37648271 0.24 Cyp26c1
 cytochrome P450, family 26, subfamily c, polypeptide 1
 37390
 0.14
chr8_114117394_114117594 0.24 Nudt7
 nudix (nucleoside diphosphate linked moiety X)-type motif 7
 16063
 0.27
chr1_31094891_31095067 0.24 4931428L18Rik
 RIKEN cDNA 4931428L18 gene
 1475
 0.35
chr6_115884148_115884359 0.23 Ift122
 intraflagellar transport 122
 1655
 0.26
chr10_125327017_125327436 0.23 Slc16a7
 solute carrier family 16 (monocarboxylic acid transporters), member 7
 1309
 0.51
chr7_137697020_137697186 0.23 Gm45682
 predicted gene 45682
 37163
 0.18
chr1_191254506_191254830 0.23 Gm37074
 predicted gene, 37074
 5244
 0.15
chr19_12719350_12719546 0.23 Gm15962
 predicted gene 15962
 1755
 0.22
chr7_71370855_71371052 0.23 Gm29328
 predicted gene 29328
 620
 0.73
chr3_52338842_52339028 0.22 Gm38034
 predicted gene, 38034
 56694
 0.1
chr7_81250438_81250962 0.22 Gm7180
 predicted pseudogene 7180
 27826
 0.13
chr2_169634592_169634925 0.22 Tshz2
 teashirt zinc finger family member 2
 1082
 0.55
chr17_86470447_86470748 0.22 Prkce
 protein kinase C, epsilon
 19965
 0.22
chr3_101430547_101430727 0.22 Gm42538
 predicted gene 42538
 3701
 0.2
chr7_25987036_25987409 0.22 Gm45225
 predicted gene 45225
 5720
 0.14
chr4_124704877_124705041 0.22 Fhl3
 four and a half LIM domains 3
 4239
 0.1
chr4_60591701_60591858 0.22 Mup-ps5
 major urinary protein, pseudogene 5
 5818
 0.16
chr11_98784049_98784205 0.22 Nr1d1
 nuclear receptor subfamily 1, group D, member 1
 8794
 0.1
chr12_3867079_3867237 0.22 Dnmt3a
 DNA methyltransferase 3A
 967
 0.52
chr6_67102942_67103110 0.22 A430010J10Rik
 RIKEN cDNA A430010J10 gene
 12647
 0.15
chr11_16842718_16842956 0.22 Egfros
 epidermal growth factor receptor, opposite strand
 12135
 0.2
chr4_118123096_118123255 0.22 St3gal3
 ST3 beta-galactoside alpha-2,3-sialyltransferase 3
 11707
 0.16
chr6_145855503_145855668 0.22 Gm43909
 predicted gene, 43909
 7712
 0.17
chr16_34322645_34322806 0.22 Kalrn
 kalirin, RhoGEF kinase
 39074
 0.22
chr11_23101055_23101224 0.21 Gm12059
 predicted gene 12059
 33141
 0.12
chr12_118792020_118792190 0.21 Gm6171
 predicted gene 6171
 1727
 0.38
chr13_81368031_81368195 0.21 Adgrv1
 adhesion G protein-coupled receptor V1
 16487
 0.26
chr13_4143590_4143758 0.21 Akr1c18
 aldo-keto reductase family 1, member C18
 6954
 0.13
chr11_79305709_79305885 0.21 Gm9964
 predicted gene 9964
 8891
 0.16
chr11_106268502_106268656 0.21 Smarcd2
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
 780
 0.42
chr6_27967716_27967883 0.21 Mir592
 microRNA 592
 31049
 0.23
chr14_69729701_69729901 0.21 Chmp7
 charged multivesicular body protein 7
 1074
 0.4
chr13_115090695_115090877 0.21 Pelo
 pelota mRNA surveillance and ribosome rescue factor
 600
 0.58
chr1_138510594_138510753 0.20 Gm28501
 predicted gene 28501
 4942
 0.23
chr9_78149872_78150023 0.20 Cilk1
 ciliogenesis associated kinase 1
 5376
 0.13
chr11_22893094_22893344 0.20 Gm24917
 predicted gene, 24917
 24318
 0.11
chr2_102706025_102706412 0.20 Slc1a2
 solute carrier family 1 (glial high affinity glutamate transporter), member 2
 138
 0.97
chr12_79642030_79642203 0.20 9430078K24Rik
 RIKEN cDNA 9430078K24 gene
 282617
 0.01
chr4_60149368_60149527 0.20 Mup2
 major urinary protein 2
 4842
 0.19
chr3_97631636_97631799 0.20 Fmo5
 flavin containing monooxygenase 5
 2834
 0.19
chr4_60299101_60299261 0.20 Mup-ps3
 major urinary protein, pseudogene 3
 61836
 0.09
chr5_63936466_63936784 0.20 Rell1
 RELT-like 1
 5711
 0.18
chr17_35242702_35242853 0.20 Gm22589
 predicted gene, 22589
 99
 0.48
chr11_16894642_16894943 0.20 Egfr
 epidermal growth factor receptor
 10393
 0.2
chr5_130024306_130024463 0.20 Asl
 argininosuccinate lyase
 3
 0.96
chr4_60231470_60231627 0.20 Mup-ps3
 major urinary protein, pseudogene 3
 5797
 0.2
chr2_24839386_24839554 0.20 Ehmt1
 euchromatic histone methyltransferase 1
 121
 0.95
chr12_73408646_73408959 0.19 D830013O20Rik
 RIKEN cDNA D830013O20 gene
 755
 0.63
chr14_11569795_11569971 0.19 Ptprg
 protein tyrosine phosphatase, receptor type, G
 16302
 0.21
chr13_104035617_104035778 0.19 Nln
 neurolysin (metallopeptidase M3 family)
 870
 0.63
chr3_95901553_95901705 0.19 Car14
 carbonic anhydrase 14
 2119
 0.14
chr4_144957116_144957269 0.19 Gm38074
 predicted gene, 38074
 1656
 0.38
chr16_62881474_62881642 0.19 Pros1
 protein S (alpha)
 16591
 0.19
chr1_21228840_21229005 0.19 Gm38224
 predicted gene, 38224
 5800
 0.13
chr8_10439826_10440109 0.19 Myo16
 myosin XVI
 167395
 0.03
chr7_99170677_99170840 0.19 Dgat2
 diacylglycerol O-acyltransferase 2
 652
 0.61
chr12_76431059_76431246 0.19 Ppp1r36
 protein phosphatase 1, regulatory subunit 36
 4561
 0.12
chr4_61844883_61845043 0.19 Mup5
 major urinary protein 5
 9730
 0.12
chr4_148616208_148616450 0.19 Tardbp
 TAR DNA binding protein
 191
 0.9
chr19_34745215_34745404 0.19 Slc16a12
 solute carrier family 16 (monocarboxylic acid transporters), member 12
 1980
 0.23
chr4_61312938_61313093 0.19 Mup-ps11
 major urinary protein, pseudogene 11
 5715
 0.2
chr16_70352273_70352442 0.19 Gbe1
 glucan (1,4-alpha-), branching enzyme 1
 38223
 0.19
chr16_13159523_13159853 0.19 Ercc4
 excision repair cross-complementing rodent repair deficiency, complementation group 4
 27297
 0.22
chr18_24054985_24055136 0.19 Gm18085
 predicted gene, 18085
 26864
 0.14
chr9_57723131_57723308 0.19 Edc3
 enhancer of mRNA decapping 3
 14652
 0.12
chr8_128350486_128350652 0.19 Nrp1
 neuropilin 1
 8035
 0.23
chr9_99353176_99353333 0.19 Esyt3
 extended synaptotagmin-like protein 3
 5264
 0.13
chr13_99667017_99667216 0.18 1700012J22Rik
 RIKEN cDNA 1700012J22 gene
 25142
 0.18
chr1_176982464_176982654 0.18 Gm37519
 predicted gene, 37519
 8323
 0.15
chr5_31199891_31200213 0.18 Zfp513
 zinc finger protein 513
 234
 0.8
chr2_64093669_64093820 0.18 Fign
 fidgetin
 4244
 0.37
chr17_84269883_84270034 0.18 Gm24492
 predicted gene, 24492
 17789
 0.18

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxb4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1 0.4 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.1 0.3 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1 0.2 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.1 0.2 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.1 0.1 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1 0.3 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.1 0.2 GO:1901078 negative regulation of relaxation of muscle(GO:1901078)
0.0 0.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.1 GO:0015889 cobalamin transport(GO:0015889)
0.0 0.1 GO:0035359 negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0 0.2 GO:0060023 soft palate development(GO:0060023)
0.0 0.1 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.0 0.1 GO:1901475 pyruvate transmembrane transport(GO:1901475)
0.0 0.1 GO:0002086 diaphragm contraction(GO:0002086)
0.0 0.1 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0 0.3 GO:0006265 DNA topological change(GO:0006265)
0.0 0.3 GO:0060613 fat pad development(GO:0060613)
0.0 0.3 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.0 0.2 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.1 GO:0070966 nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0 0.1 GO:0046499 S-adenosylmethioninamine metabolic process(GO:0046499)
0.0 0.1 GO:0032789 saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0 0.1 GO:0046951 ketone body biosynthetic process(GO:0046951)
0.0 0.3 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0 0.1 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.0 0.1 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.1 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.0 0.1 GO:0015819 lysine transport(GO:0015819)
0.0 0.1 GO:0032914 positive regulation of transforming growth factor beta1 production(GO:0032914)
0.0 0.0 GO:0006549 isoleucine metabolic process(GO:0006549)
0.0 0.1 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0 0.1 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.4 GO:0017144 drug metabolic process(GO:0017144)
0.0 0.1 GO:1902109 negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.0 0.1 GO:1903553 positive regulation of extracellular exosome assembly(GO:1903553)
0.0 0.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
0.0 0.0 GO:2000587 regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0 0.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 0.0 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 0.0 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.0 0.1 GO:0060830 ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0 0.0 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578)
0.0 0.0 GO:0017187 peptidyl-glutamic acid carboxylation(GO:0017187)
0.0 0.0 GO:0021886 cerebral cortex tangential migration using cell-axon interactions(GO:0021824) gonadotrophin-releasing hormone neuronal migration to the hypothalamus(GO:0021828) hypothalamic tangential migration using cell-axon interactions(GO:0021856) hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888) sensory neuron axon guidance(GO:0097374) facioacoustic ganglion development(GO:1903375)
0.0 0.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
0.0 0.1 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.0 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0 0.1 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.0 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0 0.1 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 0.1 GO:0090427 activation of meiosis(GO:0090427)
0.0 0.1 GO:0002513 tolerance induction to self antigen(GO:0002513)
0.0 0.1 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 0.1 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816)
0.0 0.1 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0 0.0 GO:0035771 interleukin-4-mediated signaling pathway(GO:0035771)
0.0 0.0 GO:0021699 cerebellar cortex maturation(GO:0021699)
0.0 0.1 GO:0016264 gap junction assembly(GO:0016264)
0.0 0.0 GO:0016115 terpenoid catabolic process(GO:0016115)
0.0 0.0 GO:2000741 positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0 0.0 GO:0038161 prolactin signaling pathway(GO:0038161)
0.0 0.0 GO:0021943 formation of radial glial scaffolds(GO:0021943)
0.0 0.0 GO:0006573 valine metabolic process(GO:0006573)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.0 GO:0071926 cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0 0.1 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0 0.0 GO:0046864 retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0 0.0 GO:0070889 platelet alpha granule organization(GO:0070889)
0.0 0.0 GO:0008050 female courtship behavior(GO:0008050)
0.0 0.1 GO:0010739 positive regulation of protein kinase A signaling(GO:0010739)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
0.1 0.3 GO:0001651 dense fibrillar component(GO:0001651)
0.0 0.1 GO:0044308 axonal spine(GO:0044308)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.1 GO:1990597 AIP1-IRE1 complex(GO:1990597)
0.0 0.1 GO:0008282 ATP-sensitive potassium channel complex(GO:0008282)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0030062 mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 0.0 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.1 GO:0030061 mitochondrial crista(GO:0030061)
0.0 0.1 GO:0005688 U6 snRNP(GO:0005688)
0.0 0.0 GO:0097441 basilar dendrite(GO:0097441)
0.0 0.0 GO:0044316 cone cell pedicle(GO:0044316)
0.0 0.1 GO:0002177 manchette(GO:0002177)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.3 GO:0015526 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.1 0.2 GO:0016842 amidine-lyase activity(GO:0016842)
0.1 0.3 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.1 0.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.1 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.0 0.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.1 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 0.1 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0030621 U4 snRNA binding(GO:0030621)
0.0 0.1 GO:0035671 enone reductase activity(GO:0035671)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0031419 cobalamin binding(GO:0031419)
0.0 0.1 GO:0000064 L-ornithine transmembrane transporter activity(GO:0000064)
0.0 0.1 GO:0004720 protein-lysine 6-oxidase activity(GO:0004720)
0.0 0.1 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.2 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313)
0.0 0.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.0 0.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0 0.1 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.1 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0 0.5 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.2 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.0 0.0 GO:0004487 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.1 GO:0034802 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.0 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
0.0 0.1 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.0 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0 0.0 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.0 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.0 GO:0030984 kininogen binding(GO:0030984)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.0 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.5 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
0.0 0.1 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.0 0.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters