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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Hoxc4_Arx_Otp_Esx1_Phox2b

Z-value: 0.88

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Transcription factors associated with Hoxc4_Arx_Otp_Esx1_Phox2b

Gene Symbol	Gene ID	Gene Info
Hoxc4 Ensembl NCBI MGI UniProt	ENSMUSG00000075394.3	homeobox C4
Arx Ensembl NCBI MGI UniProt	ENSMUSG00000035277.9	aristaless related homeobox
Otp Ensembl NCBI MGI UniProt	ENSMUSG00000021685.10	orthopedia homeobox
Esx1 Ensembl NCBI MGI UniProt	ENSMUSG00000023443.7	extraembryonic, spermatogenesis, homeobox 1
Phox2b Ensembl NCBI MGI UniProt	ENSMUSG00000012520.8	paired-like homeobox 2b

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chrX_93281375_93281550	Arx	4983	0.249545	-0.75	8.5e-02	Click!
chrX_93305904_93306060	Arx	19472	0.219806	-0.54	2.6e-01	Click!
chr13_94929247_94929398	Otp	46722	0.112046	-0.39	4.5e-01	Click!
chr13_94868720_94868871	Otp	6807	0.208618	-0.14	7.9e-01	Click!

Activity of the Hoxc4_Arx_Otp_Esx1_Phox2b motif across conditions

Conditions sorted by the z-value of the Hoxc4_Arx_Otp_Esx1_Phox2b motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_138080510_138080792	2.25	Zkscan1	zinc finger with KRAB and SCAN domains 1	4433	0.1
chr12_21142640_21142894	2.05	Asap2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	30813	0.16
chr19_43971247_43971535	1.32	Cpn1	carboxypeptidase N, polypeptide 1	2698	0.21
chr13_64229004_64229155	1.16	Cdc14b	CDC14 cell division cycle 14B	16797	0.1
chr3_133765600_133766533	1.11	Gm6135	prediticted gene 6135	25438	0.2
chr10_115337191_115337351	1.07	Tmem19	transmembrane protein 19	11793	0.14
chr13_59875722_59876043	1.06	Gm48384	predicted gene, 48384	2240	0.23
chr13_117745874_117746186	1.04	4933413L06Rik	RIKEN cDNA 4933413L06 gene	26019	0.26
chr5_150228070_150228236	1.02	Gm36378	predicted gene, 36378	15710	0.19
chr2_165921904_165922055	0.97	Gm11461	predicted gene 11461	3862	0.16
chr11_86917162_86917343	0.90	Ypel2	yippee like 2	54772	0.11
chr10_31644816_31644968	0.90	Gm8793	predicted gene 8793	5734	0.23
chr16_24394028_24394581	0.88	Lpp	LIM domain containing preferred translocation partner in lipoma	566	0.73
chr6_121878156_121878361	0.87	Mug1	murinoglobulin 1	7319	0.2
chr11_112218841_112219019	0.85	Gm11680	predicted gene 11680	111492	0.07
chr13_58058115_58058280	0.85	Mir874	microRNA 874	34997	0.13
chr1_181000299_181000450	0.82	Ephx1	epoxide hydrolase 1, microsomal	4204	0.11
chr12_78248706_78249176	0.81	Gm18899	predicted gene, 18899	7494	0.15
chr15_31279226_31279377	0.79	Gm49296	predicted gene, 49296	2788	0.19
chr6_121874198_121874349	0.76	Mug1	murinoglobulin 1	11304	0.19
chr2_136986571_136986744	0.75	Slx4ip	SLX4 interacting protein	81114	0.08
chr6_121890040_121890777	0.75	Mug1	murinoglobulin 1	4831	0.21
chrX_48193537_48193988	0.74	Zdhhc9	zinc finger, DHHC domain containing 9	14566	0.16
chr14_50991070_50991230	0.73	Gm49038	predicted gene, 49038	5925	0.08
chr1_119253363_119253514	0.71	Gm3508	predicted gene 3508	10685	0.22
chr4_54875588_54875760	0.70	Gm12479	predicted gene 12479	22546	0.23
chr12_4526866_4527037	0.69	Gm31938	predicted gene, 31938	2838	0.19
chr3_94338287_94338715	0.69	Gm43743	predicted gene 43743	3169	0.1
chr8_36706136_36706391	0.69	Dlc1	deleted in liver cancer 1	26791	0.24
chr16_10952807_10952965	0.69	Gm26268	predicted gene, 26268	12838	0.11
chr19_38356216_38356572	0.66	Gm50150	predicted gene, 50150	13780	0.14
chr3_107949519_107949837	0.65	Gm12494	predicted gene 12494	3443	0.09
chr13_43232894_43233157	0.65	Tbc1d7	TBC1 domain family, member 7	61524	0.1
chr10_28095778_28096012	0.64	Ptprk	protein tyrosine phosphatase, receptor type, K	20885	0.21
chr9_105878487_105878719	0.64	Col6a5	collagen, type VI, alpha 5	3203	0.27
chr13_93629307_93629685	0.63	Gm15622	predicted gene 15622	4114	0.18
chr2_165559022_165559181	0.63	Eya2	EYA transcriptional coactivator and phosphatase 2	35931	0.12
chr14_20319722_20320198	0.62	Nudt13	nudix (nucleoside diphosphate linked moiety X)-type motif 13	8531	0.12
chr2_45443502_45443687	0.61	Gm13479	predicted gene 13479	86329	0.09
chr4_148085280_148085458	0.61	Agtrap	angiotensin II, type I receptor-associated protein	593	0.56
chr10_40095200_40095431	0.60	Gm25613	predicted gene, 25613	14147	0.14
chr9_57391313_57391472	0.59	Ppcdc	phosphopantothenoylcysteine decarboxylase	29926	0.12
chr3_119368468_119368634	0.59	Gm23432	predicted gene, 23432	270323	0.02
chr11_49088297_49088883	0.58	Gm12188	predicted gene 12188	47	0.79
chr13_43500025_43500247	0.58	Gm47683	predicted gene, 47683	31	0.97
chr6_148139673_148139824	0.58	Ergic2	ERGIC and golgi 2	43460	0.13
chr1_119189619_119189770	0.58	Gm8321	predicted gene 8321	32108	0.17
chr11_81374417_81374616	0.58	4930527B05Rik	RIKEN cDNA 4930527B05 gene	10497	0.3
chr18_46336206_46336490	0.58	4930415P13Rik	RIKEN cDNA 4930415P13 gene	4081	0.17
chr5_45476407_45476609	0.58	Lap3	leucine aminopeptidase 3	16866	0.11
chr15_38661347_38661720	0.57	Atp6v1c1	ATPase, H+ transporting, lysosomal V1 subunit C1	400	0.79
chr10_96854885_96855043	0.57	Gm24587	predicted gene, 24587	706	0.71
chr18_65149682_65149843	0.57	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	5972	0.25
chr9_7571293_7571444	0.56	Mmp27	matrix metallopeptidase 27	28	0.97
chr9_44591082_44591233	0.56	Gm47231	predicted gene, 47231	6861	0.08
chr1_165609107_165609258	0.56	Mpzl1	myelin protein zero-like 1	364	0.78
chr17_18321520_18321874	0.56	Vmn2r93	vomeronasal 2, receptor 93	23598	0.19
chr11_100836746_100836921	0.55	Stat5b	signal transducer and activator of transcription 5B	13705	0.12
chr4_55245568_55245866	0.55	Gm12508	predicted gene 12508	9023	0.17
chr17_30632040_30632191	0.55	Dnah8	dynein, axonemal, heavy chain 8	3641	0.14
chr10_43378887_43379063	0.55	Rps19-ps11	ribosomal protein S19, pseudogene 11	5055	0.15
chr1_24612181_24612351	0.55	Gm28439	predicted gene 28439	144	0.72
chr5_114553798_114553965	0.54	Gm13790	predicted gene 13790	2592	0.24
chr2_164158645_164158808	0.54	n-R5s207	nuclear encoded rRNA 5S 207	1205	0.29
chr12_8643213_8643385	0.54	Pum2	pumilio RNA-binding family member 2	30835	0.16
chr8_128687947_128688299	0.54	Itgb1	integrin beta 1 (fibronectin receptor beta)	2253	0.29
chr19_36629275_36629447	0.54	Hectd2os	Hectd2, opposite strand	3337	0.28
chr11_95711926_95712160	0.53	Zfp652	zinc finger protein 652	630	0.43
chr3_119194156_119194307	0.53	Gm43410	predicted gene 43410	325987	0.01
chr6_65569857_65570008	0.53	Tnip3	TNFAIP3 interacting protein 3	20466	0.22
chr1_183979753_183980270	0.53	Dusp10	dual specificity phosphatase 10	33291	0.16
chr12_85291673_85291832	0.52	Zc2hc1c	zinc finger, C2HC-type containing 1C	3161	0.14
chr11_70713419_70713657	0.52	Mir6925	microRNA 6925	7548	0.08
chr8_4313834_4314030	0.52	Elavl1	ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R)	1313	0.29
chr3_80058876_80059038	0.51	A330069K06Rik	RIKEN cDNA A330069K06 gene	4065	0.25
chr3_146778044_146778430	0.51	Prkacb	protein kinase, cAMP dependent, catalytic, beta	3179	0.23
chr7_122666197_122666401	0.51	Cacng3	calcium channel, voltage-dependent, gamma subunit 3	4193	0.22
chr12_28636385_28636550	0.50	Rps7	ribosomal protein S7	514	0.71
chr3_119261070_119261221	0.50	Gm23432	predicted gene, 23432	377729	0.01
chr11_116021292_116021891	0.50	H3f3b	H3.3 histone B	2882	0.14
chr2_179292139_179292587	0.49	Gm14293	predicted gene 14293	51873	0.14
chr15_64309233_64309403	0.49	Asap1	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	2371	0.28
chr2_126562513_126562799	0.49	Slc27a2	solute carrier family 27 (fatty acid transporter), member 2	2104	0.32
chr4_6539560_6539735	0.48	Gm11801	predicted gene 11801	86	0.98
chr18_57571362_57571554	0.48	Ccdc192	coiled-coil domain containing 192	8282	0.17
chr11_109475236_109475399	0.48	Slc16a6	solute carrier family 16 (monocarboxylic acid transporters), member 6	1719	0.22
chr3_108030847_108030998	0.48	Gm12499	predicted gene 12499	439	0.6
chr3_81233539_81233911	0.48	Gm37300	predicted gene, 37300	171847	0.03
chr11_23954708_23954885	0.48	Gm12062	predicted gene 12062	25942	0.16
chr1_59381588_59381854	0.48	Gm29016	predicted gene 29016	2791	0.27
chr9_116291010_116291488	0.48	D730003K21Rik	RIKEN cDNA D730003K21 gene	36088	0.18
chr12_71840957_71841139	0.47	Gm7985	predicted gene 7985	6243	0.21
chr1_40117818_40118037	0.47	Gm37347	predicted gene, 37347	29416	0.14
chr4_116019975_116020341	0.47	Faah	fatty acid amide hydrolase	2232	0.22
chr15_100400715_100400907	0.47	Slc11a2	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2	2432	0.17
chr13_8591659_8591833	0.46	Gm48262	predicted gene, 48262	38726	0.19
chr13_30242706_30242889	0.46	Mboat1	membrane bound O-acyltransferase domain containing 1	10944	0.22
chr12_111454567_111454858	0.46	Tnfaip2	tumor necrosis factor, alpha-induced protein 2	4193	0.14
chr2_132654710_132655013	0.46	Rpl23a-ps4	ribosomal protein L23A, pseudogene 4	7381	0.12
chr19_5840987_5841190	0.46	Neat1	nuclear paraspeckle assembly transcript 1 (non-protein coding)	4171	0.09
chr19_56821183_56821529	0.46	Ccdc186	coiled-coil domain containing 186	834	0.58
chr18_61398040_61398397	0.46	Mir378a	microRNA 378a	318	0.54
chr19_46138051_46138212	0.45	Pitx3	paired-like homeodomain transcription factor 3	842	0.48
chr9_70935063_70935240	0.45	Lipc	lipase, hepatic	343	0.89
chr14_100132110_100132261	0.45	Klf12	Kruppel-like factor 12	17579	0.24
chr19_61057720_61057890	0.45	Gm22520	predicted gene, 22520	44260	0.12
chr17_24007025_24007189	0.45	Gm50066	predicted gene, 50066	2495	0.11
chr17_29381584_29381926	0.45	Fgd2	FYVE, RhoGEF and PH domain containing 2	5254	0.14
chr13_93653363_93653698	0.45	Bhmt	betaine-homocysteine methyltransferase	15569	0.13
chr4_116689870_116690150	0.45	Prdx1	peroxiredoxin 1	2698	0.15
chr5_147469423_147469844	0.44	Pan3	PAN3 poly(A) specific ribonuclease subunit	16344	0.12
chr9_36794772_36794937	0.44	Ei24	etoposide induced 2.4 mRNA	2166	0.21
chr16_76349002_76349359	0.44	Nrip1	nuclear receptor interacting protein 1	23857	0.18
chr14_74866246_74866397	0.43	Lrch1	leucine-rich repeats and calponin homology (CH) domain containing 1	18934	0.21
chr7_38187215_38187367	0.43	1600014C10Rik	RIKEN cDNA 1600014C10 gene	1020	0.43
chr19_30096271_30096642	0.43	Uhrf2	ubiquitin-like, containing PHD and RING finger domains 2	4495	0.24
chr3_18054195_18054346	0.43	Bhlhe22	basic helix-loop-helix family, member e22	96	0.97
chr14_66552999_66553150	0.43	Gm23899	predicted gene, 23899	38621	0.18
chr4_33229770_33229937	0.42	Pnrc1	proline-rich nuclear receptor coactivator 1	17722	0.14
chr2_169724086_169724281	0.42	Tshz2	teashirt zinc finger family member 2	90507	0.08
chr14_60635934_60636102	0.42	Spata13	spermatogenesis associated 13	1263	0.52
chr15_54947760_54948020	0.42	Gm26684	predicted gene, 26684	4180	0.19
chr6_5496841_5497314	0.42	Pdk4	pyruvate dehydrogenase kinase, isoenzyme 4	768	0.76
chr6_17255791_17255960	0.42	Cav2	caveolin 2	25310	0.17
chr15_77208076_77208227	0.41	Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	4715	0.18
chrX_161939930_161940295	0.41	Gm15202	predicted gene 15202	31889	0.21
chr11_30792834_30792985	0.41	Psme4	proteasome (prosome, macropain) activator subunit 4	18628	0.14
chr4_132129267_132129447	0.41	Oprd1	opioid receptor, delta 1	15129	0.1
chr3_138426007_138426180	0.41	Adh4	alcohol dehydrogenase 4 (class II), pi polypeptide	10598	0.13
chr4_104869752_104870593	0.41	C8a	complement component 8, alpha polypeptide	6211	0.21
chr7_75470307_75470471	0.41	Gm44834	predicted gene 44834	11610	0.16
chr17_56470014_56470183	0.41	Ptprs	protein tyrosine phosphatase, receptor type, S	4529	0.17
chr10_41627379_41627538	0.41	Ccdc162	coiled-coil domain containing 162	14621	0.15
chr8_71405347_71405498	0.41	Ankle1	ankyrin repeat and LEM domain containing 1	588	0.54
chr6_121872993_121873786	0.40	Mug1	murinoglobulin 1	12188	0.19
chr7_127666140_127666314	0.40	Gm44760	predicted gene 44760	7993	0.08
chr7_84171490_84171660	0.40	Gm22177	predicted gene, 22177	1010	0.47
chr14_119831250_119831463	0.40	4930404K13Rik	RIKEN cDNA 4930404K13 gene	32378	0.19
chr2_36092387_36092643	0.40	Lhx6	LIM homeobox protein 6	1758	0.26
chr13_54566023_54566188	0.40	4833439L19Rik	RIKEN cDNA 4833439L19 gene	670	0.53
chr13_20090144_20090306	0.40	Elmo1	engulfment and cell motility 1	371	0.92
chr15_82290409_82290560	0.39	Septin3	septin 3	6054	0.09
chr6_35874026_35874908	0.39	Gm43442	predicted gene 43442	52244	0.17
chr2_66712021_66712193	0.39	Scn7a	sodium channel, voltage-gated, type VII, alpha	72807	0.1
chr1_136229022_136229181	0.39	Inava	innate immunity activator	918	0.4
chr10_25563128_25563279	0.39	Gm29571	predicted gene 29571	26817	0.14
chr12_3575421_3575577	0.39	Dtnb	dystrobrevin, beta	2515	0.31
chr2_14099979_14100130	0.39	Stam	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	25627	0.12
chr3_81676672_81676850	0.39	Gm43346	predicted gene 43346	44915	0.18
chr5_113041682_113041833	0.38	Gm22740	predicted gene, 22740	2387	0.2
chr8_12804734_12804948	0.38	Atp11a	ATPase, class VI, type 11A	6575	0.17
chr1_180211878_180212203	0.38	Gm37336	predicted gene, 37336	296	0.87
chr9_77921035_77921417	0.38	Elovl5	ELOVL family member 5, elongation of long chain fatty acids (yeast)	706	0.62
chr8_71699244_71699423	0.38	B3gnt3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	2456	0.13
chr6_39241464_39242040	0.38	Gm43479	predicted gene 43479	1638	0.32
chr7_34485188_34485527	0.37	Gm12780	predicted gene 12780	10708	0.16
chr10_81407875_81408026	0.37	Nfic	nuclear factor I/C	309	0.68
chr9_70942553_70942713	0.37	Lipc	lipase, hepatic	7825	0.21
chr6_134743647_134743846	0.37	Dusp16	dual specificity phosphatase 16	80	0.96
chr15_34493251_34493646	0.37	Rida	reactive intermediate imine deaminase A homolog	1723	0.21
chr12_118887325_118887612	0.37	Abcb5	ATP-binding cassette, sub-family B (MDR/TAP), member 5	3291	0.3
chr1_75652903_75653256	0.37	Gm5257	predicted gene 5257	16689	0.16
chr19_42126675_42126826	0.36	Avpi1	arginine vasopressin-induced 1	2239	0.19
chr9_8134789_8134974	0.36	Cep126	centrosomal protein 126	587	0.72
chr9_66414274_66414486	0.36	Gm28379	predicted gene 28379	6261	0.21
chr10_68276454_68276805	0.36	Arid5b	AT rich interactive domain 5B (MRF1-like)	2092	0.36
chr9_58242475_58242626	0.36	Pml	promyelocytic leukemia	7073	0.12
chr6_120242684_120242877	0.36	B4galnt3	beta-1,4-N-acetyl-galactosaminyl transferase 3	137	0.97
chr19_3864646_3865022	0.35	Gm50383	predicted gene, 50383	2839	0.13
chr12_8217539_8217881	0.35	Gm33037	predicted gene, 33037	8545	0.19
chr10_20622440_20622618	0.35	Gm17230	predicted gene 17230	3106	0.32
chr13_102905828_102906396	0.35	Mast4	microtubule associated serine/threonine kinase family member 4	6	0.99
chr13_74920338_74920722	0.35	Hnrnpa1l2-ps	heterogeneous nuclear ribonucleoprotein A1-like 2, pseudogene	56225	0.14
chr10_115298774_115299175	0.35	Rab21	RAB21, member RAS oncogene family	16617	0.14
chr4_116695063_116695819	0.35	Prdx1	peroxiredoxin 1	8129	0.1
chr11_45943515_45943691	0.35	Lsm11	U7 snRNP-specific Sm-like protein LSM11	1332	0.38
chr5_74623982_74624188	0.35	Lnx1	ligand of numb-protein X 1	564	0.75
chr9_71073997_71074158	0.35	Gm47268	predicted gene, 47268	52765	0.13
chr3_118507933_118508602	0.35	Gm37773	predicted gene, 37773	17884	0.14
chr19_24270105_24270479	0.35	Fxn	frataxin	7879	0.18
chr10_53348308_53348525	0.35	Cep85l	centrosomal protein 85-like	1407	0.3
chr12_25061032_25061199	0.35	Gm47701	predicted gene, 47701	3577	0.2
chr17_84997546_84997697	0.35	Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	3941	0.22
chr19_21784354_21784521	0.34	Cemip2	cell migration inducing hyaluronidase 2	6049	0.23
chr12_25161386_25161720	0.34	Gm36287	predicted gene, 36287	10638	0.17
chr17_4196946_4197109	0.34	4930548J01Rik	RIKEN cDNA 4930548J01 gene	74914	0.12
chr3_132917768_132917922	0.34	Npnt	nephronectin	11486	0.16
chr5_9059681_9059838	0.34	Gm40264	predicted gene, 40264	24635	0.13
chr14_22783164_22783347	0.34	Gm7473	predicted gene 7473	8011	0.31
chr9_108291116_108291267	0.34	Nicn1	nicolin 1	736	0.43
chr2_103490980_103491171	0.34	Cat	catalase	5915	0.2
chr13_17716892_17717054	0.34	Gm48621	predicted gene, 48621	7109	0.12
chr15_26355371_26355533	0.34	Marchf11	membrane associated ring-CH-type finger 11	32267	0.24
chr7_49458254_49458469	0.34	Nav2	neuron navigator 2	7601	0.23
chr13_42342253_42342427	0.34	Gm47118	predicted gene, 47118	37349	0.17
chr4_32507009_32507324	0.34	Bach2	BTB and CNC homology, basic leucine zipper transcription factor 2	5661	0.25
chr5_151137806_151137957	0.34	Stard13	StAR-related lipid transfer (START) domain containing 13	10338	0.25
chr18_9786838_9787153	0.34	Gm23350	predicted gene, 23350	23733	0.11
chr11_3208642_3208934	0.34	Eif4enif1	eukaryotic translation initiation factor 4E nuclear import factor 1	5158	0.13
chr13_14192509_14192814	0.33	Arid4b	AT rich interactive domain 4B (RBP1-like)	1484	0.37

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc4_Arx_Otp_Esx1_Phox2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.9	GO:0046473	phosphatidic acid metabolic process(GO:0046473)
0.1	0.6	GO:0038161	prolactin signaling pathway(GO:0038161)
0.1	0.3	GO:0070827	chromatin maintenance(GO:0070827)
0.1	0.2	GO:0015744	succinate transport(GO:0015744)
0.1	0.3	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.1	0.6	GO:0002489	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489)
0.1	0.2	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.1	0.2	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.1	0.2	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.1	0.1	GO:0072309	mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309)
0.1	0.2	GO:0070458	detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.1	0.2	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.1	0.2	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.1	0.4	GO:0071267	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.1	0.2	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.1	0.2	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.1	0.2	GO:0019464	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.1	0.2	GO:0034421	post-translational protein acetylation(GO:0034421)
0.1	0.2	GO:0036258	multivesicular body assembly(GO:0036258)
0.1	0.5	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.1	0.1	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.1	0.2	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.1	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.1	0.2	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.1	0.3	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.1	0.1	GO:0060585	regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1	0.1	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.1	0.2	GO:1904672	regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis(GO:0072039) negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis(GO:0072040) mesenchymal cell apoptotic process involved in nephron morphogenesis(GO:1901145) regulation of somatic stem cell population maintenance(GO:1904672) negative regulation of somatic stem cell population maintenance(GO:1904673)
0.1	0.4	GO:0021540	corpus callosum morphogenesis(GO:0021540)
0.1	0.2	GO:0035553	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1	0.2	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.1	0.3	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1	0.2	GO:0001543	ovarian follicle rupture(GO:0001543)
0.1	0.1	GO:0002019	regulation of renal output by angiotensin(GO:0002019)
0.1	0.1	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.2	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.2	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0	0.1	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.2	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.2	GO:0070836	caveola assembly(GO:0070836)
0.0	0.2	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.2	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.2	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.3	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.3	GO:0071501	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.2	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.2	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.0	GO:0032345	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	0.4	GO:0006544	glycine metabolic process(GO:0006544)
0.0	0.3	GO:0002756	MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0	0.1	GO:1990791	dorsal root ganglion development(GO:1990791)
0.0	0.3	GO:0060613	fat pad development(GO:0060613)
0.0	0.2	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.3	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.2	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.1	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0	0.2	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0045626	negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0	0.1	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.0	0.2	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.4	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.3	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.0	0.4	GO:0038166	angiotensin-activated signaling pathway(GO:0038166)
0.0	0.1	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0	0.1	GO:0048633	positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0	0.1	GO:1904504	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0	0.1	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
0.0	0.1	GO:0035964	COPI-coated vesicle budding(GO:0035964)
0.0	0.1	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.0	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0	0.1	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.0	0.1	GO:0090071	negative regulation of ribosome biogenesis(GO:0090071)
0.0	0.1	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0	0.3	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.1	GO:0033024	mast cell homeostasis(GO:0033023) mast cell apoptotic process(GO:0033024) regulation of mast cell apoptotic process(GO:0033025)
0.0	0.1	GO:0060066	oviduct development(GO:0060066)
0.0	0.2	GO:0090527	actin filament reorganization(GO:0090527)
0.0	0.1	GO:0050705	regulation of interleukin-1 alpha secretion(GO:0050705)
0.0	0.1	GO:0060744	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.2	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.0	GO:0018916	nitrobenzene metabolic process(GO:0018916)
0.0	0.1	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.2	GO:0019367	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0051295	establishment of meiotic spindle localization(GO:0051295)
0.0	0.1	GO:0071442	positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0	0.1	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:0016479	negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.0	0.3	GO:0021702	cerebellar Purkinje cell differentiation(GO:0021702)
0.0	0.2	GO:0035811	negative regulation of urine volume(GO:0035811)
0.0	0.1	GO:0046098	guanine metabolic process(GO:0046098)
0.0	0.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.1	GO:0009642	response to light intensity(GO:0009642)
0.0	0.3	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.1	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.1	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0	0.1	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0	0.2	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0034627	'de novo' NAD biosynthetic process(GO:0034627)
0.0	0.1	GO:0042045	epithelial fluid transport(GO:0042045)
0.0	0.1	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.1	GO:0031119	tRNA pseudouridine synthesis(GO:0031119)
0.0	0.1	GO:0010166	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0	0.1	GO:0097195	pilomotor reflex(GO:0097195)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0071504	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.0	GO:0060594	mammary gland specification(GO:0060594)
0.0	0.1	GO:0015888	thiamine transport(GO:0015888)
0.0	0.1	GO:0016078	tRNA catabolic process(GO:0016078)
0.0	0.1	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.0	0.0	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.0	0.2	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.1	GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.1	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0	0.2	GO:0046040	IMP metabolic process(GO:0046040)
0.0	0.1	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.1	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:1904668	positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0	0.1	GO:0010744	positive regulation of macrophage derived foam cell differentiation(GO:0010744)
0.0	0.1	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.2	GO:2000811	negative regulation of anoikis(GO:2000811)
0.0	0.1	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.2	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.1	GO:0042891	antibiotic transport(GO:0042891)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:1902093	positive regulation of sperm motility(GO:1902093)
0.0	0.7	GO:0016601	Rac protein signal transduction(GO:0016601)
0.0	0.0	GO:2001274	negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.0	0.1	GO:0016576	histone dephosphorylation(GO:0016576)
0.0	0.2	GO:0061000	negative regulation of dendritic spine development(GO:0061000)
0.0	0.1	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0	0.1	GO:0061623	galactose catabolic process via UDP-galactose(GO:0033499) glycolytic process from galactose(GO:0061623)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.1	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.0	0.1	GO:1900242	regulation of synaptic vesicle endocytosis(GO:1900242)
0.0	0.1	GO:0007529	establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.0	GO:0043974	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.0	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.1	GO:0044332	Wnt signaling pathway involved in dorsal/ventral axis specification(GO:0044332)
0.0	0.0	GO:0071608	macrophage inflammatory protein-1 alpha production(GO:0071608)
0.0	0.2	GO:0010839	negative regulation of keratinocyte proliferation(GO:0010839)
0.0	0.2	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0	0.1	GO:0046337	phosphatidylethanolamine metabolic process(GO:0046337)
0.0	0.0	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.0	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.1	GO:0035426	extracellular matrix-cell signaling(GO:0035426)
0.0	0.1	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.1	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.0	0.1	GO:1902231	positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.0	0.1	GO:0045651	positive regulation of macrophage differentiation(GO:0045651)
0.0	0.4	GO:0030212	hyaluronan metabolic process(GO:0030212)
0.0	0.3	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.1	GO:0051466	positive regulation of corticotropin-releasing hormone secretion(GO:0051466)
0.0	0.0	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.0	0.1	GO:0021853	cerebral cortex GABAergic interneuron migration(GO:0021853) interneuron migration(GO:1904936)
0.0	0.0	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0034116	positive regulation of heterotypic cell-cell adhesion(GO:0034116)
0.0	0.1	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.0	0.1	GO:1901069	guanosine-containing compound catabolic process(GO:1901069)
0.0	0.1	GO:0071494	cellular response to UV-C(GO:0071494)
0.0	0.1	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.9	GO:0007566	embryo implantation(GO:0007566)
0.0	0.0	GO:2000389	regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.0	0.0	GO:2000416	regulation of eosinophil migration(GO:2000416) positive regulation of eosinophil migration(GO:2000418)
0.0	0.0	GO:0019230	proprioception(GO:0019230)
0.0	0.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.1	GO:0051014	actin filament severing(GO:0051014)
0.0	0.0	GO:0031296	B cell costimulation(GO:0031296)
0.0	0.0	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.0	GO:0002175	protein localization to paranode region of axon(GO:0002175)
0.0	0.1	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0	0.0	GO:2000173	negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0	0.0	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.1	GO:0097062	dendritic spine maintenance(GO:0097062)
0.0	0.1	GO:0060057	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0071404	cellular response to low-density lipoprotein particle stimulus(GO:0071404)
0.0	0.0	GO:0038108	negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.0	0.1	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	0.0	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.1	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0	0.1	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.0	0.0	GO:0035262	gonad morphogenesis(GO:0035262)
0.0	0.1	GO:0060665	regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
0.0	0.0	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0	0.1	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.2	GO:0035278	miRNA mediated inhibition of translation(GO:0035278)
0.0	0.1	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0	0.0	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.0	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.0	GO:0030070	insulin processing(GO:0030070)
0.0	0.0	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.1	GO:0032482	Rab protein signal transduction(GO:0032482)
0.0	0.4	GO:0048873	homeostasis of number of cells within a tissue(GO:0048873)
0.0	0.1	GO:0030497	fatty acid elongation(GO:0030497)
0.0	0.0	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
0.0	0.1	GO:0022038	corpus callosum development(GO:0022038)
0.0	0.0	GO:0070889	platelet alpha granule organization(GO:0070889)
0.0	0.0	GO:0010993	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0	0.0	GO:0043134	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0	0.1	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.0	GO:0032074	negative regulation of nuclease activity(GO:0032074)
0.0	0.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.0	GO:0021586	pons maturation(GO:0021586)
0.0	0.0	GO:1900157	regulation of bone mineralization involved in bone maturation(GO:1900157)
0.0	0.1	GO:0071481	cellular response to X-ray(GO:0071481)
0.0	0.0	GO:0061110	dense core granule biogenesis(GO:0061110)
0.0	0.1	GO:0008090	retrograde axonal transport(GO:0008090)
0.0	0.0	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.1	GO:0046881	positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0042256	mature ribosome assembly(GO:0042256)
0.0	0.1	GO:0001765	membrane raft assembly(GO:0001765)
0.0	0.1	GO:0060971	embryonic heart tube left/right pattern formation(GO:0060971)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.0	GO:2001023	regulation of response to drug(GO:2001023)
0.0	0.0	GO:1903011	negative regulation of bone development(GO:1903011)
0.0	0.0	GO:1901535	regulation of DNA demethylation(GO:1901535) negative regulation of DNA demethylation(GO:1901536)
0.0	0.0	GO:2000121	regulation of removal of superoxide radicals(GO:2000121)
0.0	0.2	GO:0020027	hemoglobin metabolic process(GO:0020027)
0.0	0.0	GO:0072674	multinuclear osteoclast differentiation(GO:0072674) regulation of osteoclast proliferation(GO:0090289) positive regulation of osteoclast proliferation(GO:0090290)
0.0	0.0	GO:0072282	metanephric nephron tubule morphogenesis(GO:0072282)
0.0	0.0	GO:1901656	glycoside transport(GO:1901656)
0.0	0.0	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.0	GO:2000040	regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
0.0	0.0	GO:1902202	regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202)
0.0	0.1	GO:0043153	entrainment of circadian clock by photoperiod(GO:0043153)
0.0	0.1	GO:0006348	chromatin silencing at telomere(GO:0006348)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.2	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
0.0	0.4	GO:0090662	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0	0.0	GO:0006203	dGTP catabolic process(GO:0006203)
0.0	0.1	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.0	0.1	GO:0018230	peptidyl-L-cysteine S-palmitoylation(GO:0018230) peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine(GO:0018231)
0.0	0.1	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.0	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.1	GO:0090232	positive regulation of spindle checkpoint(GO:0090232)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.1	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0	0.0	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	0.0	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
0.0	0.1	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.0	GO:0061687	detoxification of copper ion(GO:0010273) detoxification of inorganic compound(GO:0061687) stress response to copper ion(GO:1990169)
0.0	0.1	GO:0098719	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0	0.1	GO:0006670	sphingosine metabolic process(GO:0006670)
0.0	0.0	GO:0021932	hindbrain radial glia guided cell migration(GO:0021932)
0.0	0.0	GO:0002432	granuloma formation(GO:0002432)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0045041	protein import into mitochondrial intermembrane space(GO:0045041)
0.0	0.1	GO:0071578	zinc II ion transmembrane import(GO:0071578)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0051970	negative regulation of transmission of nerve impulse(GO:0051970)
0.0	0.0	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	0.7	GO:0090630	activation of GTPase activity(GO:0090630)
0.0	0.0	GO:0061038	uterus morphogenesis(GO:0061038)
0.0	0.0	GO:0034454	microtubule anchoring at centrosome(GO:0034454)
0.0	0.0	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.2	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.0	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.0	0.2	GO:0009954	proximal/distal pattern formation(GO:0009954)
0.0	0.0	GO:1901317	regulation of sperm motility(GO:1901317)
0.0	0.0	GO:0051799	negative regulation of hair follicle development(GO:0051799)
0.0	0.0	GO:0014827	intestine smooth muscle contraction(GO:0014827)
0.0	0.1	GO:0048102	autophagic cell death(GO:0048102)
0.0	0.0	GO:0010940	positive regulation of necrotic cell death(GO:0010940)
0.0	0.0	GO:0030579	ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0	0.0	GO:0051775	response to redox state(GO:0051775)
0.0	0.0	GO:1902237	positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237)
0.0	0.1	GO:0035428	hexose transmembrane transport(GO:0035428)
0.0	0.0	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.1	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.1	GO:0051647	nucleus localization(GO:0051647)
0.0	0.1	GO:0045717	negative regulation of fatty acid biosynthetic process(GO:0045717)
0.0	0.0	GO:0021648	vestibulocochlear nerve morphogenesis(GO:0021648)
0.0	0.1	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.1	GO:0051292	nuclear pore complex assembly(GO:0051292)
0.0	0.0	GO:0051541	elastin metabolic process(GO:0051541)
0.0	0.0	GO:0055098	response to low-density lipoprotein particle(GO:0055098)
0.0	0.0	GO:0019244	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.1	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.1	0.3	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.1	0.5	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1	0.2	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.1	0.3	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1	0.2	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.1	0.4	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1	0.2	GO:0071203	WASH complex(GO:0071203)
0.0	0.1	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.2	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0031523	Myb complex(GO:0031523)
0.0	0.2	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.4	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.3	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.3	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0090498	extrinsic component of Golgi membrane(GO:0090498)
0.0	0.1	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
0.0	0.2	GO:0071204	histone pre-mRNA 3'end processing complex(GO:0071204)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.3	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.6	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.3	GO:0005847	mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.0	0.3	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.2	GO:0032797	SMN complex(GO:0032797)
0.0	0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0034457	Mpp10 complex(GO:0034457)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0	0.2	GO:0090543	Flemming body(GO:0090543)
0.0	0.3	GO:0035686	sperm fibrous sheath(GO:0035686)
0.0	0.1	GO:0097513	myosin II filament(GO:0097513)
0.0	0.3	GO:0071565	nBAF complex(GO:0071565)
0.0	0.1	GO:0031417	NatC complex(GO:0031417)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.2	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.2	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.0	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.4	GO:0097546	ciliary base(GO:0097546)
0.0	0.1	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.5	GO:0032040	small-subunit processome(GO:0032040)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.1	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.1	GO:0031209	SCAR complex(GO:0031209)
0.0	0.8	GO:0032587	ruffle membrane(GO:0032587)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.2	GO:0002178	palmitoyltransferase complex(GO:0002178)
0.0	0.0	GO:0000176	nuclear exosome (RNase complex)(GO:0000176)
0.0	0.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.0	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	0.1	GO:0031010	ISWI-type complex(GO:0031010)
0.0	0.2	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.0	GO:0005712	chiasma(GO:0005712)
0.0	0.0	GO:0005745	m-AAA complex(GO:0005745)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.0	GO:0035838	growing cell tip(GO:0035838)
0.0	0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.0	GO:0043511	inhibin complex(GO:0043511)
0.0	0.2	GO:0043189	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0	0.0	GO:0097504	Gemini of coiled bodies(GO:0097504)
0.0	0.0	GO:0042627	chylomicron(GO:0042627)
0.0	0.0	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	0.1	GO:0005688	U6 snRNP(GO:0005688)
0.0	0.1	GO:0001931	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.1	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.2	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.1	GO:0060091	kinocilium(GO:0060091)
0.0	0.0	GO:0071942	XPC complex(GO:0071942)
0.0	0.0	GO:0033596	TSC1-TSC2 complex(GO:0033596)
0.0	0.4	GO:0005720	nuclear heterochromatin(GO:0005720)
0.0	0.1	GO:0061700	GATOR2 complex(GO:0061700)
0.0	0.1	GO:0031931	TORC1 complex(GO:0031931)
0.0	0.0	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
0.0	0.0	GO:0000178	exosome (RNase complex)(GO:0000178)
0.0	0.0	GO:0097255	R2TP complex(GO:0097255)
0.0	0.1	GO:0071546	pi-body(GO:0071546)
0.0	0.0	GO:0005828	kinetochore microtubule(GO:0005828)
0.0	0.0	GO:0030891	VCB complex(GO:0030891)
0.0	0.0	GO:0031933	telomeric heterochromatin(GO:0031933)
0.0	0.1	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0005736	DNA-directed RNA polymerase I complex(GO:0005736)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.0	GO:0000938	GARP complex(GO:0000938)
0.0	0.0	GO:0031094	platelet dense tubular network(GO:0031094)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.2	0.5	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.1	0.5	GO:0004945	angiotensin type II receptor activity(GO:0004945)
0.1	0.3	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.1	0.3	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1	0.1	GO:0034046	poly(G) binding(GO:0034046)
0.1	0.2	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.1	0.3	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.1	0.3	GO:0030151	molybdenum ion binding(GO:0030151)
0.1	0.2	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.1	0.3	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.3	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.4	GO:0034783	3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0	0.1	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.2	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.2	GO:0019960	C-X3-C chemokine binding(GO:0019960)
0.0	0.1	GO:0071209	U7 snRNA binding(GO:0071209)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	0.1	GO:0003985	acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0	0.3	GO:0004445	inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.0	0.5	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0	0.3	GO:0019855	calcium channel inhibitor activity(GO:0019855)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.1	GO:0015563	uptake transmembrane transporter activity(GO:0015563)
0.0	0.6	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0008410	CoA-transferase activity(GO:0008410)
0.0	0.2	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.1	GO:0015205	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
0.0	0.1	GO:0015087	cobalt ion transmembrane transporter activity(GO:0015087)
0.0	0.1	GO:0019145	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.1	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	0.1	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.2	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.2	GO:0102338	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.3	GO:0016645	oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.0	0.2	GO:0018642	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0004706	JUN kinase kinase kinase activity(GO:0004706)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.2	GO:0034889	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.1	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.2	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0	0.2	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.0	0.1	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.1	GO:0018685	alkane 1-monooxygenase activity(GO:0018685)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.1	GO:0030519	snoRNP binding(GO:0030519)
0.0	0.2	GO:0034784	pivalyl-CoA mutase activity(GO:0034784) o-hydroxylaminobenzoate mutase activity(GO:0034951) lupeol synthase activity(GO:0042299) beta-amyrin synthase activity(GO:0042300) baruol synthase activity(GO:0080011)
0.0	0.1	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0	0.4	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.1	GO:0035473	lipase binding(GO:0035473)
0.0	0.0	GO:0004774	succinate-CoA ligase activity(GO:0004774)
0.0	0.2	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.3	GO:0004185	serine-type carboxypeptidase activity(GO:0004185)
0.0	0.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.0	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.1	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.0	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.0	0.1	GO:0003696	satellite DNA binding(GO:0003696)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.1	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.1	GO:0019966	interleukin-1 binding(GO:0019966)
0.0	0.0	GO:0016742	hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0	0.1	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
0.0	0.0	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.0	0.1	GO:0034648	histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648)
0.0	0.1	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.0	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0031708	endothelin B receptor binding(GO:0031708)
0.0	0.3	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0042895	antibiotic transporter activity(GO:0042895)
0.0	0.3	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290) azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.0	GO:0005146	leukemia inhibitory factor receptor binding(GO:0005146)
0.0	0.0	GO:0016972	thiol oxidase activity(GO:0016972)
0.0	0.0	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.0	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0	0.1	GO:0034711	inhibin binding(GO:0034711)
0.0	0.0	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.0	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	0.1	GO:0018812	3-hydroxyacyl-CoA dehydratase activity(GO:0018812)
0.0	0.1	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.1	GO:0032051	clathrin light chain binding(GO:0032051)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	0.1	GO:0000150	recombinase activity(GO:0000150)
0.0	0.1	GO:0031748	D1 dopamine receptor binding(GO:0031748)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.0	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.2	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
0.0	0.1	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.2	GO:0070717	poly-purine tract binding(GO:0070717)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)
0.0	0.1	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.1	GO:0009378	four-way junction helicase activity(GO:0009378)
0.0	0.0	GO:1904680	peptide transmembrane transporter activity(GO:1904680)
0.0	0.2	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.0	0.1	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.2	GO:0070300	phosphatidic acid binding(GO:0070300)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.0	GO:0042284	sphingolipid delta-4 desaturase activity(GO:0042284)
0.0	0.0	GO:0046978	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.1	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.1	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.0	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.4	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	0.0	GO:0008390	testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.0	0.1	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.0	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.1	GO:0032795	heterotrimeric G-protein binding(GO:0032795)
0.0	0.2	GO:0016594	glycine binding(GO:0016594)
0.0	0.1	GO:0001054	RNA polymerase I activity(GO:0001054)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.0	GO:0035373	chondroitin sulfate proteoglycan binding(GO:0035373)
0.0	0.2	GO:0015026	coreceptor activity(GO:0015026)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.3	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.1	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.0	GO:0008732	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.1	GO:0070513	death domain binding(GO:0070513)
0.0	0.0	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0	0.1	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.1	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.0	GO:0004741	[pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	0.1	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	0.1	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0	0.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.3	PID ARF 3PATHWAY	Arf1 pathway
0.0	0.6	PID IL8 CXCR2 PATHWAY	IL8- and CXCR2-mediated signaling events
0.0	0.8	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.3	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.4	PID WNT NONCANONICAL PATHWAY	Noncanonical Wnt signaling pathway
0.0	0.2	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	0.4	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.1	ST STAT3 PATHWAY	STAT3 Pathway
0.0	0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.2	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.3	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.0	0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.0	0.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.1	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.0	0.2	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.0	0.1	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.5	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.3	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.3	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.3	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0	0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.0	0.3	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.0	0.3	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.4	REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB	Genes involved in PKA-mediated phosphorylation of CREB
0.0	0.5	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.4	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.2	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.4	REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	Genes involved in The role of Nef in HIV-1 replication and disease pathogenesis
0.0	0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.0	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.0	0.2	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0	0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.1	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.0	REACTOME PYRUVATE METABOLISM	Genes involved in Pyruvate metabolism
0.0	0.0	REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	Genes involved in Cytokine Signaling in Immune system
0.0	0.3	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.1	REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS	Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.0	0.1	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.1	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.0	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.0	0.0	REACTOME P75NTR SIGNALS VIA NFKB	Genes involved in p75NTR signals via NF-kB
0.0	0.2	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.1	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
0.0	0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.1	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.1	REACTOME TIE2 SIGNALING	Genes involved in Tie2 Signaling
0.0	0.2	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.2	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.2	REACTOME AMYLOIDS	Genes involved in Amyloids
0.0	0.3	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.0	0.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	0.0	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis

Results for Hoxc4_Arx_Otp_Esx1_Phox2b

Z-value: 0.88

Motif logo

Transcription factors associated with Hoxc4_Arx_Otp_Esx1_Phox2b

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Hoxc4_Arx_Otp_Esx1_Phox2b motif across conditions

Conditions sorted by the z-value of the Hoxc4_Arx_Otp_Esx1_Phox2b motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc4_Arx_Otp_Esx1_Phox2b

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: