Project

ENCSR904DTN: DNase-seq of mouse liver in constant darkness

Navigation

Downloads

CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Hoxc6

Z-value: 1.05

Motif logo

Transcription factors associated with Hoxc6

Gene Symbol	Gene ID	Gene Info
Hoxc6 Ensembl NCBI MGI UniProt	ENSMUSG00000001661.4	Hoxc6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Hoxc6	chr15_102999275_102999447	1104	0.276127	-0.35	4.9e-01	Click!

Activity of the Hoxc6 motif across conditions

Conditions sorted by the z-value of the Hoxc6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_9968620_9968771	0.65	Tcf24	transcription factor 24	763	0.41
chr19_39287276_39287531	0.58	Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	329	0.91
chr2_60118945_60119257	0.57	Gm13620	predicted gene 13620	5995	0.16
chr7_104995535_104995703	0.54	Olfr672	olfactory receptor 672	1283	0.2
chr5_29596501_29596658	0.53	Ube3c	ubiquitin protein ligase E3C	5750	0.22
chr8_45341558_45341748	0.53	Cyp4v3	cytochrome P450, family 4, subfamily v, polypeptide 3	8437	0.15
chr2_134491985_134492278	0.52	Hao1	hydroxyacid oxidase 1, liver	62176	0.15
chr4_47366562_47366857	0.52	Tgfbr1	transforming growth factor, beta receptor I	13099	0.22
chr6_108281132_108281339	0.52	Itpr1	inositol 1,4,5-trisphosphate receptor 1	28277	0.22
chr11_28696545_28697113	0.50	2810471M01Rik	RIKEN cDNA 2810471M01 gene	15265	0.17
chr2_131345745_131345918	0.47	Rnf24	ring finger protein 24	7031	0.14
chr13_119432132_119432318	0.42	Paip1	polyadenylate binding protein-interacting protein 1	3067	0.2
chr2_130932638_130932843	0.41	Atrn	attractin	25809	0.11
chr13_34626488_34626639	0.41	Gm47127	predicted gene, 47127	14317	0.13
chr3_117078471_117078622	0.39	1700061I17Rik	RIKEN cDNA 1700061I17 gene	781	0.64
chr19_37323790_37323978	0.37	Ide	insulin degrading enzyme	6729	0.16
chr10_88719373_88719562	0.36	Gm48144	predicted gene, 48144	3373	0.12
chr1_188125975_188126247	0.36	Gm38315	predicted gene, 38315	34596	0.21
chr13_102570134_102570306	0.36	Gm29927	predicted gene, 29927	20065	0.22
chr5_21175987_21176254	0.35	Gsap	gamma-secretase activating protein	10135	0.15
chr17_35590917_35591091	0.35	Sfta2	surfactant associated 2	10545	0.08
chr1_100298746_100298897	0.35	Gm29667	predicted gene 29667	16030	0.18
chr15_3533289_3533452	0.33	Ghr	growth hormone receptor	48472	0.16
chr4_88893074_88893256	0.33	Ifne	interferon epsilon	12964	0.08
chr9_42461424_42462009	0.33	Tbcel	tubulin folding cofactor E-like	255	0.91
chr3_138287619_138288216	0.33	Adh1	alcohol dehydrogenase 1 (class I)	10266	0.12
chr6_100204562_100204726	0.33	Rybp	RING1 and YY1 binding protein	28487	0.15
chr15_60694082_60694233	0.32	Gm23835	predicted gene, 23835	9966	0.19
chr13_95772378_95772529	0.32	Iqgap2	IQ motif containing GTPase activating protein 2	8056	0.19
chr11_115459206_115459357	0.31	Slc16a5	solute carrier family 16 (monocarboxylic acid transporters), member 5	3193	0.1
chr7_120604351_120604519	0.31	E130201H02Rik	RIKEN cDNA E130201H02 gene	6810	0.11
chr2_168734428_168734613	0.31	Atp9a	ATPase, class II, type 9A	181	0.95
chr10_95354659_95354831	0.31	2310039L15Rik	RIKEN cDNA 2310039L15 gene	143	0.94
chr16_93873807_93873958	0.30	Chaf1b	chromatin assembly factor 1, subunit B (p60)	10019	0.13
chr19_12771696_12771894	0.30	Cntf	ciliary neurotrophic factor	6163	0.12
chr15_32923240_32923575	0.30	Sdc2	syndecan 2	2684	0.39
chr4_131882954_131883105	0.29	Srsf4	serine and arginine-rich splicing factor 4	1266	0.29
chr3_60097884_60098081	0.29	Sucnr1	succinate receptor 1	16080	0.18
chr16_56714341_56714503	0.29	Tfg	Trk-fused gene	1446	0.47
chr13_9077339_9077490	0.29	Gm36264	predicted gene, 36264	963	0.5
chr13_95811525_95811676	0.28	Iqgap2	IQ motif containing GTPase activating protein 2	47203	0.13
chr11_43783562_43783743	0.28	Ttc1	tetratricopeptide repeat domain 1	35644	0.16
chr2_155583504_155583661	0.28	Gss	glutathione synthetase	920	0.33
chr12_36155790_36155945	0.27	Bzw2	basic leucine zipper and W2 domains 2	760	0.46
chr4_10835624_10835785	0.27	Mir3471-1	microRNA 3471-1	9926	0.12
chr19_41244661_41244826	0.27	Tm9sf3	transmembrane 9 superfamily member 3	19237	0.21
chr5_7964334_7964518	0.27	Steap4	STEAP family member 4	3969	0.19
chr9_108309327_108309485	0.27	Rhoa	ras homolog family member A	2577	0.11
chr3_5425056_5425268	0.27	4930555M17Rik	RIKEN cDNA 4930555M17 gene	90171	0.09
chr1_185370452_185370690	0.27	Eprs	glutamyl-prolyl-tRNA synthetase	2974	0.15
chr13_41219562_41219715	0.27	Elovl2	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 2	524	0.68
chr2_50284584_50284735	0.27	Mmadhc	methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria	4540	0.25
chr2_35060101_35060327	0.26	Hc	hemolytic complement	1224	0.43
chr5_90315666_90315817	0.26	Ankrd17	ankyrin repeat domain 17	11637	0.21
chr4_106354190_106354378	0.26	Usp24	ubiquitin specific peptidase 24	38050	0.13
chr17_81386388_81386573	0.26	Gm50044	predicted gene, 50044	15647	0.24
chr17_47923114_47923463	0.26	Gm15556	predicted gene 15556	910	0.38
chr16_30386539_30386690	0.25	Atp13a3	ATPase type 13A3	1871	0.37
chr6_67268305_67268456	0.25	Serbp1	serpine1 mRNA binding protein 1	1050	0.44
chr12_78218868_78219034	0.25	Gphn	gephyrin	7428	0.15
chr1_72583626_72583816	0.25	Smarcal1	SWI/SNF related matrix associated, actin dependent regulator of chromatin, subfamily a-like 1	106	0.97
chr1_139780384_139780535	0.25	Gm4788	predicted gene 4788	709	0.69
chr2_64079562_64079736	0.25	Fign	fidgetin	18339	0.3
chr13_101760313_101760479	0.25	Gm36638	predicted gene, 36638	7191	0.21
chr3_75530671_75531016	0.25	Pdcd10	programmed cell death 10	9273	0.2
chr2_48403972_48404299	0.25	Gm13472	predicted gene 13472	16098	0.2
chr7_70483265_70483615	0.25	Gm7656	predicted gene 7656	7408	0.16
chr18_43131844_43132003	0.24	Gm8181	predicted gene 8181	39236	0.13
chr7_136914047_136914226	0.24	Gm45280	predicted gene 45280	6805	0.24
chr12_73855812_73855997	0.24	Gm15283	predicted gene 15283	13708	0.17
chr1_160996279_160996443	0.24	Gm37072	predicted gene, 37072	5484	0.07
chr13_97927511_97927679	0.24	Arhgef28	Rho guanine nucleotide exchange factor (GEF) 28	19332	0.21
chr11_53418931_53419109	0.24	Leap2	liver-expressed antimicrobial peptide 2	4150	0.1
chr7_100907329_100907491	0.24	Arhgef17	Rho guanine nucleotide exchange factor (GEF) 17	12720	0.14
chr10_53113782_53113941	0.24	Gm47622	predicted gene, 47622	11318	0.22
chr2_132853961_132854112	0.24	Crls1	cardiolipin synthase 1	6298	0.14
chr3_51437862_51438013	0.24	Naa15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	2980	0.14
chr8_116404224_116404375	0.24	1700018P08Rik	RIKEN cDNA 1700018P08 gene	47238	0.17
chr13_117508625_117508817	0.24	Gm5200	predicted gene 5200	49646	0.17
chr16_4772912_4773063	0.24	Cdip1	cell death inducing Trp53 target 1	1475	0.28
chr2_71498544_71498972	0.24	Gm23253	predicted gene, 23253	3487	0.17
chr10_108979346_108979586	0.24	Gm47477	predicted gene, 47477	22978	0.22
chr19_56171122_56171273	0.23	Gm31912	predicted gene, 31912	64887	0.11
chr14_114123652_114123812	0.23	Gm18369	predicted gene, 18369	48711	0.19
chr2_145233540_145233706	0.23	Slc24a3	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	8988	0.28
chr10_87831885_87832059	0.23	Igf1os	insulin-like growth factor 1, opposite strand	3610	0.27
chr3_135510262_135510447	0.23	Manba	mannosidase, beta A, lysosomal	6796	0.13
chr18_61422291_61422459	0.23	Gm8755	predicted gene 8755	11826	0.12
chr12_40608115_40608266	0.23	Dock4	dedicator of cytokinesis 4	161854	0.03
chr16_17340724_17340946	0.23	Gm24927	predicted gene, 24927	1177	0.36
chr2_5968425_5968579	0.23	Upf2	UPF2 regulator of nonsense transcripts homolog (yeast)	17033	0.17
chr6_117059962_117060118	0.23	Gm43929	predicted gene, 43929	78021	0.08
chr15_97247773_97248330	0.23	Amigo2	adhesion molecule with Ig like domain 2	764	0.48
chr2_91378186_91378346	0.23	Gm22071	predicted gene, 22071	28870	0.13
chr9_122138979_122139323	0.23	Gm47121	predicted gene, 47121	3298	0.16
chr4_82378492_82378694	0.23	n-R5s188	nuclear encoded rRNA 5S 188	60817	0.14
chr19_42150846_42151168	0.22	Marveld1	MARVEL (membrane-associating) domain containing 1	3299	0.14
chr12_54967535_54967800	0.22	Gm27014	predicted gene, 27014	4603	0.15
chr11_49260229_49260441	0.22	Mgat1	mannoside acetylglucosaminyltransferase 1	4091	0.14
chr3_138430699_138430859	0.22	Adh5	alcohol dehydrogenase 5 (class III), chi polypeptide	12314	0.12
chr8_61273697_61273901	0.22	1700001D01Rik	RIKEN cDNA 1700001D01 gene	15073	0.2
chr15_3482890_3483092	0.22	Ghr	growth hormone receptor	11347	0.28
chr12_7816660_7817001	0.22	Gm32828	predicted gene, 32828	42861	0.14
chr6_141613801_141613980	0.22	Slco1b2	solute carrier organic anion transporter family, member 1b2	15628	0.25
chr19_40154709_40154860	0.22	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	32502	0.13
chr10_124590350_124590536	0.22	4930503E24Rik	RIKEN cDNA 4930503E24 gene	67005	0.14
chr11_72631760_72631911	0.22	Gm24143	predicted gene, 24143	15685	0.13
chr2_15056785_15057135	0.21	Gm38257	predicted gene, 38257	247	0.86
chr2_130908138_130908309	0.21	Atrn	attractin	1292	0.28
chr1_102517589_102517767	0.21	Gm20281	predicted gene, 20281	58756	0.14
chr17_33667328_33667604	0.21	Hnrnpm	heterogeneous nuclear ribonucleoprotein M	896	0.43
chr10_115511796_115512121	0.21	Lgr5	leucine rich repeat containing G protein coupled receptor 5	48879	0.12
chr1_57342831_57342992	0.21	4930558J18Rik	RIKEN cDNA 4930558J18 gene	34633	0.12
chr8_41096211_41096362	0.21	Mtus1	mitochondrial tumor suppressor 1	13510	0.18
chr12_7948991_7949142	0.21	Gm48633	predicted gene, 48633	995	0.56
chr6_95003514_95003791	0.21	4930511E03Rik	RIKEN cDNA 4930511E03 gene	59818	0.12
chr10_4333753_4333924	0.21	Akap12	A kinase (PRKA) anchor protein (gravin) 12	707	0.68
chr4_72166936_72167097	0.21	Gm11250	predicted gene 11250	1752	0.4
chr4_76363527_76363872	0.21	Ptprd	protein tyrosine phosphatase, receptor type, D	19456	0.22
chr16_26702287_26702472	0.21	Il1rap	interleukin 1 receptor accessory protein	20055	0.24
chr13_64099099_64099277	0.21	Slc35d2	solute carrier family 35, member D2	7975	0.15
chr7_25448767_25449204	0.21	Gm15495	predicted gene 15495	5522	0.11
chr10_29019588_29019757	0.21	Gm9824	predicted pseudogene 9824	10456	0.14
chr18_33210537_33210688	0.20	Stard4	StAR-related lipid transfer (START) domain containing 4	3154	0.37
chr13_44432624_44432823	0.20	1700029N11Rik	RIKEN cDNA 1700029N11 gene	6989	0.16
chr19_31886956_31887132	0.20	A1cf	APOBEC1 complementation factor	18263	0.2
chr9_100619847_100620182	0.20	Gm8661	predicted gene 8661	5951	0.15
chr5_23441774_23441951	0.20	Kmt2e	lysine (K)-specific methyltransferase 2E	7413	0.15
chr5_65431439_65431654	0.20	Gm43289	predicted gene 43289	34	0.95
chr5_106573979_106574163	0.20	Gm28050	predicted gene, 28050	644	0.46
chr15_3469696_3469847	0.20	Ghr	growth hormone receptor	1873	0.48
chr3_18166354_18166574	0.20	Gm23686	predicted gene, 23686	11161	0.24
chr13_4192623_4192780	0.20	Akr1c13	aldo-keto reductase family 1, member C13	1157	0.38
chr14_14071519_14071682	0.20	Atxn7	ataxin 7	15869	0.17
chr15_11190225_11190388	0.20	Adamts12	a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 12	125488	0.05
chr3_149318468_149318647	0.20	Gm30382	predicted gene, 30382	5317	0.21
chr4_132930929_132931084	0.20	Gm24913	predicted gene, 24913	311	0.85
chr16_42999237_42999415	0.20	Ndufs5-ps	NADH:ubiquinone oxidoreductase core subunit S5, pseudogene	43695	0.16
chr2_40479361_40479517	0.19	Gm13456	predicted gene 13456	76313	0.11
chr6_54035175_54035554	0.19	Chn2	chimerin 2	4190	0.24
chr1_67091897_67092231	0.19	Cps1	carbamoyl-phosphate synthetase 1	30962	0.17
chr18_51157676_51157865	0.19	Prr16	proline rich 16	40032	0.21
chr12_7751611_7751762	0.19	Gm32828	predicted gene, 32828	108005	0.06
chr7_14529256_14529446	0.19	Obox4-ps2	oocyte specific homeobox 4, pseudogene 2	715	0.53
chr16_43403257_43403418	0.19	Gm15713	predicted gene 15713	16859	0.18
chr7_100609531_100609682	0.19	Mrpl48	mitochondrial ribosomal protein L48	1305	0.26
chr3_60515813_60516054	0.19	Mbnl1	muscleblind like splicing factor 1	12195	0.22
chr15_3570914_3571065	0.19	Ghr	growth hormone receptor	10853	0.25
chr6_47814259_47814426	0.19	Pdia4	protein disulfide isomerase associated 4	912	0.35
chr18_39503638_39503872	0.19	Nr3c1	nuclear receptor subfamily 3, group C, member 1	12454	0.26
chr11_52351256_52351613	0.19	Vdac1	voltage-dependent anion channel 1	9426	0.17
chr2_130058269_130058427	0.19	Gm22424	predicted gene, 22424	13376	0.13
chr12_79436402_79436553	0.19	Rad51b	RAD51 paralog B	109124	0.06
chr1_21261382_21261702	0.19	Gsta3	glutathione S-transferase, alpha 3	8021	0.11
chr12_57441896_57442047	0.19	Gm16246	predicted gene 16246	8149	0.23
chr7_70365214_70365757	0.19	B130024G19Rik	RIKEN cDNA B130024G19 gene	326	0.78
chr9_75037221_75037495	0.19	Arpp19	cAMP-regulated phosphoprotein 19	256	0.91
chrX_93630327_93630494	0.19	Pola1	polymerase (DNA directed), alpha 1	1705	0.34
chr9_72288048_72288199	0.19	Gm19353	predicted gene, 19353	1544	0.21
chr13_95786097_95786248	0.19	Iqgap2	IQ motif containing GTPase activating protein 2	21775	0.18
chr16_91678296_91678553	0.19	Donson	downstream neighbor of SON	2886	0.15
chr11_95365489_95365701	0.19	Fam117a	family with sequence similarity 117, member A	9872	0.12
chr15_36496930_36497165	0.19	Ankrd46	ankyrin repeat domain 46	227	0.91
chr6_14897077_14897293	0.19	Foxp2	forkhead box P2	4164	0.36
chr1_56623913_56624064	0.19	Hsfy2	heat shock transcription factor, Y-linked 2	13447	0.28
chr5_42887251_42887423	0.18	Gm5554	predicted gene 5554	77272	0.11
chr12_45069728_45070323	0.18	Stxbp6	syntaxin binding protein 6 (amisyn)	4087	0.24
chr9_111124362_111124513	0.18	Lrrfip2	leucine rich repeat (in FLII) interacting protein 2	4762	0.17
chr7_72247872_72248068	0.18	Mctp2	multiple C2 domains, transmembrane 2	18610	0.26
chr1_158541726_158541892	0.18	Gm37367	predicted gene, 37367	7002	0.15
chr1_156558196_156558347	0.18	Abl2	v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene)	515	0.76
chr9_122148160_122148327	0.18	Gm47121	predicted gene, 47121	5794	0.13
chr18_59092890_59093288	0.18	Minar2	membrane integral NOTCH2 associated receptor 2	30578	0.22
chr10_44766057_44766218	0.18	4930431F10Rik	RIKEN cDNA 4930431F10 gene	27237	0.12
chr10_69104876_69105058	0.18	Gm47107	predicted gene, 47107	7101	0.19
chr5_134311252_134311463	0.18	Gtf2i	general transcription factor II I	370	0.8
chr5_86888528_86888722	0.18	Ugt2b34	UDP glucuronosyltransferase 2 family, polypeptide B34	18312	0.1
chr6_24610042_24610446	0.18	Lmod2	leiomodin 2 (cardiac)	12482	0.14
chr9_20581625_20581828	0.18	Zfp846	zinc finger protein 846	194	0.9
chr8_68008523_68008836	0.18	Gm22018	predicted gene, 22018	1661	0.43
chr7_118571834_118571985	0.18	Tmc7	transmembrane channel-like gene family 7	5282	0.16
chr4_84545854_84546088	0.18	Bnc2	basonuclin 2	319	0.94
chr4_6923149_6923300	0.18	Tox	thymocyte selection-associated high mobility group box	67259	0.13
chr2_84727873_84728024	0.18	Clp1	CLP1, cleavage and polyadenylation factor I subunit	598	0.5
chr11_116501017_116501181	0.18	Rpl36-ps1	ribosomal protein L36, pseudogene 1	3437	0.12
chr1_31097093_31097258	0.18	4931428L18Rik	RIKEN cDNA 4931428L18 gene	721	0.62
chr17_4944661_4944832	0.18	Gm41517	predicted gene, 41517	2068	0.36
chr11_28698214_28698534	0.18	2810471M01Rik	RIKEN cDNA 2810471M01 gene	16810	0.16
chr18_43845253_43845404	0.18	Gm41715	predicted gene, 41715	5232	0.18
chr10_41886623_41887088	0.17	Sesn1	sestrin 1	584	0.78
chr14_117733261_117733423	0.17	Mir6239	microRNA 6239	220505	0.02
chr6_27753809_27753967	0.17	Gm26310	predicted gene, 26310	85801	0.1
chr5_121431395_121431558	0.17	Naa25	N(alpha)-acetyltransferase 25, NatB auxiliary subunit	7942	0.1
chr15_76314416_76314716	0.17	Oplah	5-oxoprolinase (ATP-hydrolysing)	4811	0.07
chr10_67176584_67176792	0.17	Jmjd1c	jumonji domain containing 1C	9060	0.22
chrX_152327737_152327888	0.17	Kantr	Kdm5c adjacent non-coding transcript	317	0.85
chr4_70517804_70518135	0.17	Megf9	multiple EGF-like-domains 9	16959	0.29
chrX_166458575_166458751	0.17	Trappc2	trafficking protein particle complex 2	13360	0.13
chr1_9989244_9989423	0.17	Ppp1r42	protein phosphatase 1, regulatory subunit 42	3641	0.12
chr18_6514098_6514308	0.17	Epc1	enhancer of polycomb homolog 1	1905	0.3

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxc6

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0072338	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1	0.3	GO:0000733	DNA strand renaturation(GO:0000733)
0.1	0.3	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:2000302	positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:1901097	negative regulation of autophagosome maturation(GO:1901097)
0.0	0.1	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.0	0.1	GO:0021593	rhombomere morphogenesis(GO:0021593)
0.0	0.2	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0001983	baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0014016	neuroblast differentiation(GO:0014016)
0.0	0.0	GO:0006069	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.1	GO:0061724	lipophagy(GO:0061724)
0.0	0.1	GO:0035523	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.2	GO:0034626	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0030397	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.2	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.2	GO:0006930	substrate-dependent cell migration, cell extension(GO:0006930)
0.0	0.2	GO:0060017	parathyroid gland development(GO:0060017)
0.0	0.1	GO:0006642	triglyceride mobilization(GO:0006642)
0.0	0.1	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	0.1	GO:0071918	urea transmembrane transport(GO:0071918)
0.0	0.6	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:1903599	positive regulation of mitophagy(GO:1903599)
0.0	0.0	GO:0007529	establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.0	0.2	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:1900127	positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.0	0.0	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.1	GO:0019287	isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287)
0.0	0.1	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.0	GO:0060164	regulation of timing of neuron differentiation(GO:0060164)
0.0	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.1	GO:0035542	regulation of SNARE complex assembly(GO:0035542)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.1	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	0.1	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.1	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.1	GO:1900016	negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.0	0.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.1	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.1	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.0	GO:0042427	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0	0.1	GO:0033216	ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.0	0.0	GO:0044333	Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.0	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.0	GO:0043366	beta selection(GO:0043366)
0.0	0.1	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.1	GO:1901727	positive regulation of histone deacetylase activity(GO:1901727)
0.0	0.0	GO:0044375	regulation of peroxisome size(GO:0044375)
0.0	0.0	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608)
0.0	0.1	GO:0097070	ductus arteriosus closure(GO:0097070)
0.0	0.0	GO:0003331	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0	0.0	GO:0032789	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.0	GO:0021882	regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882)
0.0	0.0	GO:0001827	inner cell mass cell fate commitment(GO:0001827)
0.0	0.1	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0033634	positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.0	0.0	GO:0009212	dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.0	0.2	GO:0045722	positive regulation of gluconeogenesis(GO:0045722)
0.0	0.1	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.0	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.0	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.1	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.0	GO:1903371	regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0	0.0	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:1902966	regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0	0.1	GO:0098596	vocal learning(GO:0042297) imitative learning(GO:0098596) learned vocalization behavior or vocal learning(GO:0098598)
0.0	0.0	GO:0055099	response to high density lipoprotein particle(GO:0055099)
0.0	0.1	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.1	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.0	0.0	GO:0015677	copper ion import(GO:0015677)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.0	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0	0.0	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.0	GO:0010982	regulation of high-density lipoprotein particle clearance(GO:0010982)
0.0	0.0	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.1	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.0	GO:0070989	oxidative demethylation(GO:0070989)
0.0	0.0	GO:0010963	regulation of L-arginine import(GO:0010963)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.0	GO:0070948	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.1	GO:0060836	lymphatic endothelial cell differentiation(GO:0060836)
0.0	0.1	GO:0044828	negative regulation by host of viral genome replication(GO:0044828)
0.0	0.1	GO:0002756	MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0	0.1	GO:0090036	regulation of protein kinase C signaling(GO:0090036)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.0	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0	0.0	GO:0070649	formin-nucleated actin cable assembly(GO:0070649)
0.0	0.0	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.0	GO:1904995	negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.0	0.3	GO:0006890	retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0	0.0	GO:0071638	negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0	0.0	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.0	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0006122	mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0045293	mRNA editing complex(GO:0045293)
0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.1	GO:0005579	membrane attack complex(GO:0005579)
0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.1	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.1	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.3	GO:0005662	DNA replication factor A complex(GO:0005662)
0.1	GO:0017059	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.1	GO:0044611	nuclear pore inner ring(GO:0044611)
0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	GO:0061700	GATOR2 complex(GO:0061700)
0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.1	GO:0030478	actin cap(GO:0030478)
0.1	GO:0042382	paraspeckles(GO:0042382)
0.1	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306)
0.1	GO:0033263	CORVET complex(GO:0033263)
0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	GO:0097452	GAIT complex(GO:0097452)
0.1	GO:0000124	SAGA complex(GO:0000124)
0.0	GO:0016602	CCAAT-binding factor complex(GO:0016602)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0033695	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1	0.2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1	0.2	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.1	GO:0070538	oleic acid binding(GO:0070538)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.3	GO:0036310	annealing helicase activity(GO:0036310)
0.0	0.1	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.2	GO:0070728	leucine binding(GO:0070728)
0.0	0.1	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.2	GO:0102337	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.1	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.1	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.0	GO:0035276	ethanol binding(GO:0035276)
0.0	0.1	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.1	GO:0103116	alpha-D-galactofuranose transporter activity(GO:0103116)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0043559	insulin binding(GO:0043559)
0.0	0.0	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
0.0	0.1	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0	0.1	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.0	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.1	GO:0008273	calcium, potassium:sodium antiporter activity(GO:0008273)
0.0	0.0	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.2	GO:0004012	phospholipid-translocating ATPase activity(GO:0004012)
0.0	0.1	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.0	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.0	GO:0098821	BMP receptor activity(GO:0098821)
0.0	0.1	GO:1990446	U1 snRNP binding(GO:1990446)
0.0	0.1	GO:0048495	Roundabout binding(GO:0048495)
0.0	0.1	GO:0018631	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.1	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	0.1	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.0	GO:0009041	uridylate kinase activity(GO:0009041)
0.0	0.0	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.1	GO:0016714	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen(GO:0016714)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.0	GO:0050693	LBD domain binding(GO:0050693)
0.0	0.1	GO:1990405	protein antigen binding(GO:1990405)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0019103	pyrimidine nucleotide binding(GO:0019103)
0.0	0.1	GO:0017040	ceramidase activity(GO:0017040)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0	0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.2	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.2	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.1	REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN	Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin