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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Hoxd8

Z-value: 1.11

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Transcription factors associated with Hoxd8

Gene Symbol	Gene ID	Gene Info
Hoxd8 Ensembl NCBI MGI UniProt	ENSMUSG00000027102.4	homeobox D8

Activity of the Hoxd8 motif across conditions

Conditions sorted by the z-value of the Hoxd8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_16574847_16575001	1.02	Gm48497	predicted gene, 48497	41103	0.17
chr4_106354190_106354378	0.72	Usp24	ubiquitin specific peptidase 24	38050	0.13
chr19_31884467_31884670	0.69	A1cf	APOBEC1 complementation factor	15787	0.21
chr16_42999869_43000020	0.62	Ndufs5-ps	NADH:ubiquinone oxidoreductase core subunit S5, pseudogene	44313	0.16
chr3_14787462_14787685	0.61	Car1	carbonic anhydrase 1	9114	0.18
chr2_154875946_154876097	0.61	Eif2s2	eukaryotic translation initiation factor 2, subunit 2 (beta)	16761	0.19
chr6_29571610_29572022	0.59	Tnpo3	transportin 3	297	0.87
chr16_30027841_30027992	0.59	9030404E10Rik	RIKEN cDNA 9030404E10 gene	11563	0.15
chr8_93183570_93183871	0.59	Gm45909	predicted gene 45909	7638	0.14
chr12_78268546_78268712	0.58	Gm48225	predicted gene, 48225	7336	0.17
chr4_123990670_123991070	0.58	Gm12902	predicted gene 12902	64636	0.08
chr3_136048131_136048315	0.55	Gm5281	predicted gene 5281	3465	0.25
chr7_132941355_132941506	0.54	Zranb1	zinc finger, RAN-binding domain containing 1	6738	0.15
chr6_28587807_28587958	0.53	Gm37978	predicted gene, 37978	19810	0.16
chr9_122826708_122826859	0.50	Gm35549	predicted gene, 35549	17103	0.1
chr8_56281836_56281987	0.50	Hpgd	hydroxyprostaglandin dehydrogenase 15 (NAD)	12674	0.23
chr12_83905337_83905488	0.49	Numb	NUMB endocytic adaptor protein	16321	0.11
chr11_100485778_100486208	0.49	Acly	ATP citrate lyase	6482	0.09
chr9_109565625_109565786	0.48	Fbxw15	F-box and WD-40 domain protein 15	2543	0.17
chr10_87040962_87041138	0.48	1700113H08Rik	RIKEN cDNA 1700113H08 gene	16995	0.16
chr9_48723477_48723685	0.47	Zbtb16	zinc finger and BTB domain containing 16	112364	0.06
chr5_40811186_40811352	0.47	Gm23022	predicted gene, 23022	405340	0.01
chr3_66982581_66983014	0.46	Shox2	short stature homeobox 2	1026	0.42
chr12_12940858_12941058	0.46	Mycn	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	342	0.83
chr19_48883437_48883771	0.46	Gm50436	predicted gene, 50436	72468	0.11
chr2_78656286_78656827	0.46	Gm14463	predicted gene 14463	873	0.71
chr1_162867938_162868165	0.45	Fmo1	flavin containing monooxygenase 1	1441	0.39
chr9_7858246_7858397	0.45	Birc3	baculoviral IAP repeat-containing 3	2005	0.3
chr2_38823684_38823849	0.44	Nr6a1os	nuclear receptor subfamily 6, group A, member 1, opposite strand	425	0.74
chr8_90953330_90953683	0.44	Chd9	chromodomain helicase DNA binding protein 9	1452	0.39
chr2_112609858_112610011	0.44	Gm44374	predicted gene, 44374	4096	0.23
chr4_136402761_136402948	0.43	Htr1d	5-hydroxytryptamine (serotonin) receptor 1D	20670	0.14
chr3_138223407_138223558	0.43	Adh7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	2011	0.23
chr3_133544844_133545488	0.43	Tet2	tet methylcytosine dioxygenase 2	27	0.53
chr3_34076650_34076843	0.42	Dnajc19	DnaJ heat shock protein family (Hsp40) member C19	3434	0.16
chr6_108666051_108666462	0.42	Bhlhe40	basic helix-loop-helix family, member e40	3210	0.21
chr17_80022007_80022158	0.41	Gm22215	predicted gene, 22215	11432	0.14
chr18_45582508_45582659	0.41	Kcnn2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	7963	0.24
chr1_100298746_100298897	0.41	Gm29667	predicted gene 29667	16030	0.18
chr12_73861884_73862127	0.41	Gm15283	predicted gene 15283	7607	0.18
chr4_6885681_6885832	0.40	Tox	thymocyte selection-associated high mobility group box	104727	0.07
chr17_64607771_64607970	0.40	Man2a1	mannosidase 2, alpha 1	7134	0.26
chr6_37510078_37510463	0.40	Akr1d1	aldo-keto reductase family 1, member D1	19903	0.21
chr3_8963133_8963313	0.40	Tpd52	tumor protein D52	823	0.64
chr16_90199492_90199754	0.40	Gm49704	predicted gene, 49704	1475	0.35
chr3_97649987_97650151	0.40	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	8124	0.13
chr4_97102666_97103047	0.40	Gm27521	predicted gene, 27521	185836	0.03
chr14_75243267_75243429	0.39	Cpb2	carboxypeptidase B2 (plasma)	1061	0.44
chr14_32179471_32179639	0.39	Ncoa4	nuclear receptor coactivator 4	2823	0.15
chr16_78490552_78490715	0.39	Gm49604	predicted gene, 49604	953	0.54
chr4_63057046_63057197	0.39	Zfp618	zinc finger protein 618	63279	0.1
chr9_15301981_15302132	0.39	4931406C07Rik	RIKEN cDNA 4931406C07 gene	500	0.46
chr2_132859056_132859242	0.39	Crls1	cardiolipin synthase 1	11411	0.13
chr12_75531904_75532183	0.39	Ppp2r5e	protein phosphatase 2, regulatory subunit B', epsilon	17631	0.18
chr19_31886956_31887132	0.38	A1cf	APOBEC1 complementation factor	18263	0.2
chr9_106264996_106265377	0.38	Poc1a	POC1 centriolar protein A	15875	0.1
chr8_34164335_34164526	0.38	Mir6395	microRNA 6395	2282	0.18
chr7_110538178_110538390	0.37	Gm10087	predicted gene 10087	11492	0.18
chr11_115167087_115167259	0.37	Slc9a3r1	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	3832	0.13
chr6_141994065_141994238	0.37	Gm6614	predicted gene 6614	14594	0.21
chr14_30530847_30531018	0.37	Dcp1a	decapping mRNA 1A	7225	0.15
chr5_147545326_147545477	0.37	Pan3	PAN3 poly(A) specific ribonuclease subunit	6124	0.21
chr7_100610040_100610203	0.37	Mrpl48	mitochondrial ribosomal protein L48	1820	0.19
chr2_121507198_121507349	0.37	Wdr76	WD repeat domain 76	490	0.46
chr10_84914599_84914750	0.37	Ric8b	RIC8 guanine nucleotide exchange factor B	2942	0.33
chr1_127787130_127787281	0.36	Ccnt2	cyclin T2	9366	0.16
chr2_115450732_115450919	0.36	3110099E03Rik	RIKEN cDNA 3110099E03 gene	61376	0.12
chr14_55468841_55469329	0.36	Dhrs4	dehydrogenase/reductase (SDR family) member 4	9673	0.1
chr14_65740190_65740357	0.36	Scara5	scavenger receptor class A, member 5	63796	0.1
chr19_55111923_55112097	0.36	Gpam	glycerol-3-phosphate acyltransferase, mitochondrial	8919	0.2
chr16_42998828_42999221	0.36	Ndufs5-ps	NADH:ubiquinone oxidoreductase core subunit S5, pseudogene	43393	0.16
chr6_8862762_8862913	0.36	Ica1	islet cell autoantigen 1	84349	0.1
chr15_59231191_59231350	0.36	Gm7691	predicted gene 7691	7219	0.19
chr19_60570173_60570324	0.36	Gm25238	predicted gene, 25238	10281	0.18
chr15_39146655_39146819	0.35	n-R5s39	nuclear encoded rRNA 5S 39	250	0.87
chr5_101758048_101758202	0.35	Cds1	CDP-diacylglycerol synthase 1	7005	0.17
chr2_19519895_19520058	0.35	Gm13345	predicted gene 13345	10659	0.16
chr15_3721208_3721477	0.35	Gm4823	predicted gene 4823	25533	0.23
chr8_36246396_36246684	0.35	Lonrf1	LON peptidase N-terminal domain and ring finger 1	2976	0.27
chr16_30941233_30941532	0.35	Gm46565	predicted gene, 46565	5753	0.18
chr13_4438641_4438805	0.35	Akr1c6	aldo-keto reductase family 1, member C6	2577	0.26
chr4_97810121_97810272	0.34	E130114P18Rik	RIKEN cDNA E130114P18 gene	32118	0.17
chr14_8425861_8426012	0.34	Gm8416	predicted gene 8416	17019	0.2
chr3_18210346_18210497	0.34	Gm23686	predicted gene, 23686	32796	0.17
chr15_44689672_44690007	0.34	Sybu	syntabulin (syntaxin-interacting)	57949	0.11
chr13_92050387_92050727	0.34	Rasgrf2	RAS protein-specific guanine nucleotide-releasing factor 2	19653	0.26
chr8_93253165_93253392	0.34	Gm45727	predicted gene 45727	2103	0.24
chr10_87896267_87896418	0.33	Igf1os	insulin-like growth factor 1, opposite strand	32961	0.15
chr6_88046142_88046293	0.33	Rab7	RAB7, member RAS oncogene family	947	0.41
chr6_26491486_26491715	0.33	Gm24691	predicted gene, 24691	31170	0.26
chr8_18713888_18714465	0.33	Angpt2	angiopoietin 2	14629	0.17
chr11_28702228_28702389	0.33	2810471M01Rik	RIKEN cDNA 2810471M01 gene	20744	0.15
chr7_84113279_84113524	0.33	Cemip	cell migration inducing protein, hyaluronan binding	26899	0.14
chr5_124228161_124228330	0.33	Pitpnm2os1	phosphatidylinositol transfer protein, membrane-associated 2, opposite strand 1	1480	0.26
chr19_26058038_26058213	0.33	1700048O14Rik	RIKEN cDNA 1700048O14 gene	11658	0.29
chr2_103790393_103790544	0.32	Caprin1	cell cycle associated protein 1	6076	0.11
chr3_131485378_131485553	0.32	Sgms2	sphingomyelin synthase 2	5014	0.28
chr5_86942001_86942153	0.32	Gm24121	predicted gene, 24121	13069	0.09
chr2_36159195_36159603	0.32	Mrrf	mitochondrial ribosome recycling factor	12296	0.12
chr10_111367147_111367312	0.32	Gm40761	predicted gene, 40761	30105	0.16
chr7_70356055_70356242	0.32	Nr2f2	nuclear receptor subfamily 2, group F, member 2	911	0.45
chr5_123865713_123865874	0.32	Hcar2	hydroxycarboxylic acid receptor 2	294	0.86
chr11_38683198_38683743	0.32	Gm23520	predicted gene, 23520	114807	0.07
chr13_100152373_100152603	0.32	Gm18413	predicted gene, 18413	2017	0.25
chr13_4512002_4512170	0.32	Akr1c20	aldo-keto reductase family 1, member C20	11227	0.18
chr15_50017534_50017718	0.31	Gm49186	predicted gene, 49186	104244	0.08
chr5_40908767_40908928	0.31	4930519E07Rik	RIKEN cDNA 4930519E07 gene	372389	0.01
chr6_100204562_100204726	0.31	Rybp	RING1 and YY1 binding protein	28487	0.15
chr10_4605236_4605428	0.31	Esr1	estrogen receptor 1 (alpha)	6261	0.23
chr3_18167606_18167757	0.31	Gm23686	predicted gene, 23686	9944	0.24
chr19_45902358_45902683	0.31	Gm6813	predicted gene 6813	24394	0.14
chrX_140545006_140545195	0.31	Tsc22d3	TSC22 domain family, member 3	1913	0.35
chr2_34049474_34049625	0.31	C230014O12Rik	RIKEN cDNA C230014O12 gene	58180	0.11
chr12_54439488_54439663	0.31	Gm7557	predicted gene 7557	9177	0.15
chr18_46655480_46655793	0.31	Gm3734	predicted gene 3734	24829	0.13
chr11_4832480_4832698	0.31	Nf2	neurofibromin 2	544	0.74
chr1_62469805_62469956	0.31	Pard3bos3	par-3 family cell polarity regulator beta, opposite strand 3	29381	0.21
chr2_107628721_107628872	0.31	Gm9864	predicted gene 9864	28257	0.26
chr5_30286285_30286785	0.31	Drc1	dynein regulatory complex subunit 1	5147	0.17
chr1_62899396_62899571	0.30	Gm4208	predicted gene 4208	67113	0.09
chr8_93277306_93277457	0.30	Ces1f	carboxylesterase 1F	2035	0.26
chr18_38370754_38370932	0.30	Gm4949	predicted gene 4949	10305	0.12
chr9_46479855_46480133	0.30	Gm47144	predicted gene, 47144	25079	0.15
chr16_25221904_25222082	0.30	Tprg	transformation related protein 63 regulated	64824	0.14
chr10_61444315_61444902	0.30	Gm48086	predicted gene, 48086	6109	0.11
chr1_67182326_67182537	0.30	Cps1	carbamoyl-phosphate synthetase 1	59405	0.11
chr3_149234408_149234559	0.30	Gm10287	predicted gene 10287	8738	0.21
chr17_10187170_10187336	0.30	Qk	quaking	26321	0.25
chr1_51751367_51751637	0.30	Gm28055	predicted gene 28055	4559	0.23
chr4_109104769_109104920	0.30	Osbpl9	oxysterol binding protein-like 9	3187	0.27
chr1_118448989_118449484	0.29	Gm26080	predicted gene, 26080	4249	0.15
chr6_124880400_124880682	0.29	Cd4	CD4 antigen	7658	0.08
chr1_88134414_88134588	0.29	Ugt1a6a	UDP glucuronosyltransferase 1 family, polypeptide A6A	308	0.71
chr2_52470397_52470548	0.29	A430018G15Rik	RIKEN cDNA A430018G15 gene	45460	0.12
chr13_9306293_9306452	0.29	Gm48887	predicted gene, 48887	15055	0.11
chr16_65665507_65665824	0.29	Gm49633	predicted gene, 49633	52246	0.14
chr1_67195986_67196354	0.29	Gm15668	predicted gene 15668	53030	0.13
chr16_56714341_56714503	0.29	Tfg	Trk-fused gene	1446	0.47
chr10_111149650_111150090	0.29	Gm8873	predicted gene 8873	6346	0.14
chr2_32606655_32606830	0.29	St6galnac6	ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6	219	0.84
chr1_66816824_66817235	0.29	Kansl1l	KAT8 regulatory NSL complex subunit 1-like	517	0.58
chr9_84497400_84497569	0.29	Gm8226	predicted gene 8226	73500	0.1
chr15_54596223_54596485	0.29	Mal2	mal, T cell differentiation protein 2	25162	0.22
chr19_32603829_32604061	0.29	Papss2	3'-phosphoadenosine 5'-phosphosulfate synthase 2	8155	0.23
chr15_59316490_59316736	0.29	Sqle	squalene epoxidase	1506	0.35
chr2_88007915_88008090	0.29	Olfr1160	olfactory receptor 1160	266	0.8
chr16_84807428_84807749	0.29	Jam2	junction adhesion molecule 2	1819	0.26
chr13_117745874_117746186	0.29	4933413L06Rik	RIKEN cDNA 4933413L06 gene	26019	0.26
chr17_32934878_32935069	0.29	Cyp4f13	cytochrome P450, family 4, subfamily f, polypeptide 13	3965	0.12
chr13_8526113_8526309	0.28	Gm48262	predicted gene, 48262	26809	0.23
chr15_102752976_102753138	0.28	Calcoco1	calcium binding and coiled coil domain 1	30879	0.11
chr10_93196295_93196461	0.28	Cdk17	cyclin-dependent kinase 17	10609	0.2
chr11_5524693_5525093	0.28	Xbp1	X-box binding protein 1	2970	0.18
chr14_20164716_20164945	0.28	Kcnk5	potassium channel, subfamily K, member 5	16979	0.13
chr15_41832966_41833117	0.28	Oxr1	oxidation resistance 1	2048	0.35
chr11_60178593_60178767	0.28	Rai1	retinoic acid induced 1	2801	0.18
chr16_26727363_26727514	0.28	Il1rap	interleukin 1 receptor accessory protein	396	0.9
chr1_163817675_163817827	0.28	Kifap3	kinesin-associated protein 3	38168	0.16
chr18_11317026_11317247	0.28	Gata6	GATA binding protein 6	258089	0.02
chr7_49764294_49764503	0.28	Htatip2	HIV-1 Tat interactive protein 2	5245	0.23
chr17_71213183_71213334	0.28	Lpin2	lipin 2	8582	0.17
chr3_106497089_106497388	0.28	Dennd2d	DENN/MADD domain containing 2D	4063	0.16
chr17_89653592_89653743	0.28	Gm50061	predicted gene, 50061	98859	0.09
chr3_100683705_100684061	0.28	Man1a2	mannosidase, alpha, class 1A, member 2	730	0.55
chr9_112785054_112785229	0.28	Gm24957	predicted gene, 24957	262612	0.02
chr1_119661376_119661532	0.27	Epb41l5	erythrocyte membrane protein band 4.1 like 5	12454	0.16
chr10_125967716_125967898	0.27	Lrig3	leucine-rich repeats and immunoglobulin-like domains 3	1554	0.53
chr2_43592382_43592533	0.27	Kynu	kynureninase	7158	0.3
chr8_68094755_68094906	0.27	Psd3	pleckstrin and Sec7 domain containing 3	26483	0.22
chr15_62746422_62746596	0.27	Gm22521	predicted gene, 22521	46692	0.18
chr1_23261263_23261446	0.27	Gm6420	predicted gene 6420	4947	0.13
chr11_109027604_109027760	0.27	Gm11668	predicted gene 11668	20031	0.18
chr6_144895356_144895507	0.27	Gm22792	predicted gene, 22792	91799	0.07
chr18_5617566_5617751	0.27	Gm22709	predicted gene, 22709	3185	0.18
chr11_106889132_106889465	0.27	Smurf2	SMAD specific E3 ubiquitin protein ligase 2	30977	0.11
chr13_6515622_6515787	0.27	2900042G08Rik	RIKEN cDNA 2900042G08 gene	14891	0.21
chr5_106140040_106140240	0.27	Gm32736	predicted gene, 32736	45049	0.13
chr14_79629212_79629374	0.27	Sugt1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	4654	0.19
chr13_19394098_19394409	0.27	Gm42683	predicted gene 42683	1200	0.38
chr2_75605802_75605972	0.27	Gm13655	predicted gene 13655	27495	0.15
chr8_40564203_40564371	0.27	Vps37a	vacuolar protein sorting 37A	20863	0.15
chr16_94606252_94606403	0.27	Gm15971	predicted gene 15971	14050	0.19
chr11_75495112_75495263	0.27	Prpf8	pre-mRNA processing factor 8	2941	0.12
chr11_102741952_102742137	0.26	Gm16342	predicted gene 16342	9639	0.11
chr2_31499430_31499808	0.26	Ass1	argininosuccinate synthetase 1	1107	0.5
chr2_48404312_48404494	0.26	Gm13472	predicted gene 13472	16366	0.2
chr10_86690446_86690597	0.26	Gm15344	predicted gene 15344	2574	0.11
chr4_124809297_124809476	0.26	Mtf1	metal response element binding transcription factor 1	6708	0.1
chr11_117845425_117845576	0.26	Birc5	baculoviral IAP repeat-containing 5	3751	0.1
chr2_31519719_31520357	0.26	Ass1	argininosuccinate synthetase 1	1548	0.36
chr1_51760527_51760678	0.26	Myo1b	myosin IB	3868	0.24
chr11_60877088_60877239	0.26	Tmem11	transmembrane protein 11	1624	0.26
chr12_101954170_101954556	0.26	Atxn3	ataxin 3	3785	0.17
chr2_77155937_77156088	0.26	Ccdc141	coiled-coil domain containing 141	14564	0.21
chr6_108834740_108834891	0.26	Edem1	ER degradation enhancer, mannosidase alpha-like 1	1595	0.43
chr17_31155739_31155923	0.26	Gm15318	predicted gene 15318	3035	0.15
chr19_39739857_39740024	0.26	Cyp2c68	cytochrome P450, family 2, subfamily c, polypeptide 68	1114	0.6
chr2_128972020_128972207	0.26	Gm10762	predicted gene 10762	4069	0.12
chr3_51437862_51438013	0.26	Naa15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	2980	0.14
chr16_17340724_17340946	0.26	Gm24927	predicted gene, 24927	1177	0.36

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.1	0.1	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.1	0.3	GO:0006068	ethanol catabolic process(GO:0006068)
0.1	0.3	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.6	GO:0006526	arginine biosynthetic process(GO:0006526)
0.1	0.2	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	0.2	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.1	0.2	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.1	0.2	GO:0003331	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.1	0.2	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.1	0.2	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.1	0.2	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.1	0.3	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.1	0.2	GO:1903984	positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.1	0.2	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.1	0.2	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	0.2	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.2	GO:0061724	lipophagy(GO:0061724)
0.1	0.5	GO:2000980	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:0010963	regulation of L-arginine import(GO:0010963)
0.0	0.5	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0015747	urate transport(GO:0015747)
0.0	0.2	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.2	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.0	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.2	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.0	0.2	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.2	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.2	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0	0.2	GO:0030647	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.3	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.5	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.2	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0009826	unidimensional cell growth(GO:0009826)
0.0	0.1	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0	0.1	GO:0006003	fructose 2,6-bisphosphate metabolic process(GO:0006003)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.3	GO:0048671	negative regulation of collateral sprouting(GO:0048671)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.2	GO:0015871	choline transport(GO:0015871)
0.0	0.1	GO:0061419	positive regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061419)
0.0	0.1	GO:2000302	positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.0	0.0	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.2	GO:0044829	positive regulation by host of viral genome replication(GO:0044829)
0.0	0.1	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.2	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.3	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0019086	late viral transcription(GO:0019086)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.1	GO:0042939	glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.0	0.2	GO:0086013	membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0	0.1	GO:0044337	canonical Wnt signaling pathway involved in positive regulation of apoptotic process(GO:0044337)
0.0	0.1	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.1	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.1	GO:0035622	intrahepatic bile duct development(GO:0035622)
0.0	0.1	GO:0042737	drug catabolic process(GO:0042737)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.2	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	0.2	GO:0019530	taurine metabolic process(GO:0019530)
0.0	0.1	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.1	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.2	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.2	GO:0006677	glycosylceramide metabolic process(GO:0006677)
0.0	0.0	GO:2000409	positive regulation of T cell extravasation(GO:2000409)
0.0	0.0	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.1	GO:0033387	putrescine biosynthetic process from ornithine(GO:0033387)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.1	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.1	GO:0021553	olfactory nerve development(GO:0021553)
0.0	0.1	GO:0001732	formation of cytoplasmic translation initiation complex(GO:0001732)
0.0	0.0	GO:2000437	monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.2	GO:0006655	phosphatidylglycerol biosynthetic process(GO:0006655)
0.0	0.1	GO:0097112	gamma-aminobutyric acid receptor clustering(GO:0097112)
0.0	0.2	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.1	GO:0061511	centriole elongation(GO:0061511)
0.0	0.0	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.0	0.0	GO:1904742	regulation of telomeric DNA binding(GO:1904742)
0.0	0.1	GO:0001842	neural fold formation(GO:0001842)
0.0	0.1	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.1	GO:0070948	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.0	0.1	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0	0.1	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.2	GO:0060546	negative regulation of necroptotic process(GO:0060546)
0.0	0.0	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.0	0.1	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.1	GO:0071681	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.2	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.1	GO:0001905	activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
0.0	0.2	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.2	GO:0006517	protein deglycosylation(GO:0006517)
0.0	0.0	GO:0030397	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.1	GO:0048318	axial mesoderm development(GO:0048318)
0.0	0.1	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.1	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.1	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.0	0.1	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0046218	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.2	GO:0001886	endothelial cell morphogenesis(GO:0001886)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.1	GO:1900084	regulation of peptidyl-tyrosine autophosphorylation(GO:1900084)
0.0	0.1	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0	0.1	GO:0070375	ERK5 cascade(GO:0070375)
0.0	0.1	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0	0.1	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.1	GO:0055091	phospholipid homeostasis(GO:0055091)
0.0	0.0	GO:0060559	positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0	0.1	GO:0045162	clustering of voltage-gated sodium channels(GO:0045162)
0.0	0.3	GO:0006825	copper ion transport(GO:0006825)
0.0	0.1	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:0032789	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0048014	Tie signaling pathway(GO:0048014)
0.0	0.1	GO:0070989	oxidative demethylation(GO:0070989)
0.0	0.1	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.1	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.1	GO:0032202	telomere assembly(GO:0032202)
0.0	0.1	GO:0042494	detection of bacterial lipoprotein(GO:0042494) detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.0	GO:0046149	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:0051661	maintenance of centrosome location(GO:0051661)
0.0	0.0	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.0	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.1	GO:0050859	negative regulation of B cell receptor signaling pathway(GO:0050859)
0.0	0.1	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0	0.1	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	0.0	GO:0048936	peripheral nervous system neuron axonogenesis(GO:0048936)
0.0	0.0	GO:0050904	diapedesis(GO:0050904)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.2	GO:0009812	flavonoid metabolic process(GO:0009812)
0.0	0.1	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902177)
0.0	0.1	GO:0051657	maintenance of organelle location(GO:0051657)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.4	GO:0043252	sodium-independent organic anion transport(GO:0043252)
0.0	0.0	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.0	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.0	0.4	GO:0019432	triglyceride biosynthetic process(GO:0019432)
0.0	0.0	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.0	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0	0.0	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.0	0.1	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.1	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	0.0	GO:1901165	positive regulation of trophoblast cell migration(GO:1901165)
0.0	0.1	GO:1902969	mitotic DNA replication(GO:1902969)
0.0	0.0	GO:2000599	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.0	0.0	GO:1903977	positive regulation of glial cell migration(GO:1903977)
0.0	0.1	GO:2001184	positive regulation of interleukin-12 secretion(GO:2001184)
0.0	0.0	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.0	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.0	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.0	GO:0014732	skeletal muscle atrophy(GO:0014732)
0.0	0.1	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.0	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.1	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:1900165	negative regulation of interleukin-6 secretion(GO:1900165)
0.0	0.0	GO:1900060	negative regulation of ceramide biosynthetic process(GO:1900060)
0.0	0.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.0	GO:0030908	intein-mediated protein splicing(GO:0016539) protein splicing(GO:0030908)
0.0	0.1	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.0	0.0	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.1	GO:0030948	negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.0	0.2	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.0	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.0	GO:1904684	negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
0.0	0.0	GO:2000224	regulation of testosterone biosynthetic process(GO:2000224)
0.0	0.0	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.0	GO:0072025	distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
0.0	0.1	GO:0010898	positive regulation of triglyceride catabolic process(GO:0010898)
0.0	0.1	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
0.0	0.1	GO:0000467	exonucleolytic trimming involved in rRNA processing(GO:0000459) exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000467)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:1904469	positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0	0.0	GO:0035672	oligopeptide transmembrane transport(GO:0035672)
0.0	0.0	GO:1903975	regulation of glial cell migration(GO:1903975)
0.0	0.1	GO:0015867	ATP transport(GO:0015867)
0.0	0.2	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.1	GO:0071267	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.0	GO:0051594	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.0	GO:1903347	negative regulation of bicellular tight junction assembly(GO:1903347)
0.0	0.0	GO:0035247	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919) peptidyl-arginine omega-N-methylation(GO:0035247)
0.0	0.0	GO:0097211	response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0	0.2	GO:0045116	protein neddylation(GO:0045116)
0.0	0.0	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0044359	modulation of molecular function in other organism(GO:0044359) negative regulation of molecular function in other organism(GO:0044362) negative regulation of molecular function in other organism involved in symbiotic interaction(GO:0052204) modulation of molecular function in other organism involved in symbiotic interaction(GO:0052205)
0.0	0.0	GO:0097368	establishment of Sertoli cell barrier(GO:0097368)
0.0	0.1	GO:0002176	male germ cell proliferation(GO:0002176)
0.0	0.1	GO:1900016	negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.0	0.0	GO:0061370	testosterone biosynthetic process(GO:0061370)
0.0	0.0	GO:0032077	positive regulation of deoxyribonuclease activity(GO:0032077)
0.0	0.0	GO:0070126	mitochondrial translational termination(GO:0070126)
0.0	0.0	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.0	0.0	GO:0010958	regulation of amino acid import(GO:0010958)
0.0	0.1	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.0	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.1	GO:0031293	membrane protein intracellular domain proteolysis(GO:0031293)
0.0	0.0	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.1	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0	0.0	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.0	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.0	GO:0006824	cobalt ion transport(GO:0006824)
0.0	0.0	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.2	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.1	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0	0.1	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0	0.0	GO:0070125	mitochondrial translational elongation(GO:0070125)
0.0	0.1	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.1	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.0	0.0	GO:0060051	negative regulation of protein glycosylation(GO:0060051)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.2	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0000811	GINS complex(GO:0000811)
0.0	0.1	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.1	GO:0070876	SOSS complex(GO:0070876)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.2	GO:0000124	SAGA complex(GO:0000124)
0.0	0.0	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.0	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.1	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.1	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.1	GO:0030313	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.1	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.2	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0034366	spherical high-density lipoprotein particle(GO:0034366)
0.0	0.1	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	0.1	GO:0097504	Gemini of coiled bodies(GO:0097504)
0.0	0.1	GO:0016939	kinesin II complex(GO:0016939)
0.0	0.1	GO:0005593	FACIT collagen trimer(GO:0005593)
0.0	0.1	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0	0.1	GO:0000306	extrinsic component of vacuolar membrane(GO:0000306)
0.0	0.3	GO:0043034	costamere(GO:0043034)
0.0	0.2	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.1	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.2	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.0	0.3	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.4	GO:0005719	nuclear euchromatin(GO:0005719)
0.0	0.0	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	0.2	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.0	GO:1990316	ATG1/ULK1 kinase complex(GO:1990316)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0036057	filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.0	0.1	GO:0071556	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.2	GO:0035371	microtubule plus-end(GO:0035371)
0.0	0.2	GO:0005682	U5 snRNP(GO:0005682)
0.0	0.1	GO:0030314	junctional membrane complex(GO:0030314)
0.0	0.0	GO:0097651	phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.0	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.3	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	0.0	GO:1990131	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	0.1	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.0	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	0.1	GO:0000813	ESCRT I complex(GO:0000813)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.1	GO:0031211	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.3	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1	0.2	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1	0.3	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.1	0.2	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1	0.2	GO:0038181	bile acid receptor activity(GO:0038181)
0.1	0.6	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1	0.2	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.1	0.2	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.1	0.2	GO:0004064	arylesterase activity(GO:0004064)
0.1	0.2	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.2	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.2	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.3	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.2	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0030158	protein xylosyltransferase activity(GO:0030158)
0.0	0.2	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.2	GO:0016724	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0009041	uridylate kinase activity(GO:0009041)
0.0	0.2	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.2	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.3	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.2	GO:0035671	enone reductase activity(GO:0035671)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.3	GO:0005167	neurotrophin TRK receptor binding(GO:0005167)
0.0	0.2	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.2	GO:0018685	alkane 1-monooxygenase activity(GO:0018685)
0.0	0.4	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.2	GO:0008494	translation activator activity(GO:0008494)
0.0	0.3	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.3	GO:0070990	snRNP binding(GO:0070990)
0.0	0.1	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.2	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0030572	cardiolipin synthase activity(GO:0008808) phosphatidyltransferase activity(GO:0030572)
0.0	0.0	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.0	GO:0050051	leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.4	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.5	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.0	0.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.4	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)
0.0	0.2	GO:0004779	sulfate adenylyltransferase activity(GO:0004779)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.0	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.1	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0	0.1	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.1	GO:0052723	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.1	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.1	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.0	0.1	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.1	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0051880	G-quadruplex DNA binding(GO:0051880)
0.0	0.0	GO:0008948	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) oxaloacetate decarboxylase activity(GO:0008948)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.0	GO:0000702	oxidized base lesion DNA N-glycosylase activity(GO:0000702)
0.0	0.2	GO:0004535	poly(A)-specific ribonuclease activity(GO:0004535)
0.0	0.2	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.2	GO:0052672	cobinamide kinase activity(GO:0008819) phytol kinase activity(GO:0010276) phenol kinase activity(GO:0018720) cyclin-dependent protein kinase activating kinase regulator activity(GO:0019914) inositol tetrakisphosphate 2-kinase activity(GO:0032942) heptose 7-phosphate kinase activity(GO:0033785) aminoglycoside phosphotransferase activity(GO:0034071) eukaryotic elongation factor-2 kinase regulator activity(GO:0042556) eukaryotic elongation factor-2 kinase activator activity(GO:0042557) LPPG:FO 2-phospho-L-lactate transferase activity(GO:0043743) cytidine kinase activity(GO:0043771) glycerate 2-kinase activity(GO:0043798) (S)-lactate 2-kinase activity(GO:0043841) phosphoserine:homoserine phosphotransferase activity(GO:0043899) L-seryl-tRNA(Sec) kinase activity(GO:0043915) phosphocholine transferase activity(GO:0044605) GTP-dependent polynucleotide kinase activity(GO:0051735) farnesol kinase activity(GO:0052668) CTP:2-trans,-6-trans-farnesol kinase activity(GO:0052669) geraniol kinase activity(GO:0052670) geranylgeraniol kinase activity(GO:0052671) CTP:geranylgeraniol kinase activity(GO:0052672) prenol kinase activity(GO:0052673) 1-phosphatidylinositol-5-kinase activity(GO:0052810) 1-phosphatidylinositol-3-phosphate 4-kinase activity(GO:0052811) phosphatidylinositol-3,4-bisphosphate 5-kinase activity(GO:0052812) inositol-3,4,6-trisphosphate 1-kinase activity(GO:0052835) inositol 5-diphosphate pentakisphosphate 5-kinase activity(GO:0052836) inositol diphosphate tetrakisphosphate kinase activity(GO:0052839)
0.0	0.1	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.0	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	0.1	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.0	0.1	GO:0004176	ATP-dependent peptidase activity(GO:0004176)
0.0	0.1	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.0	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.0	GO:0005219	ryanodine-sensitive calcium-release channel activity(GO:0005219)
0.0	0.1	GO:0097602	cullin family protein binding(GO:0097602)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.0	GO:0046870	cadmium ion binding(GO:0046870)
0.0	0.2	GO:0016502	purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.0	0.0	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.4	GO:0051723	protein methylesterase activity(GO:0051723)
0.0	0.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.0	GO:0008475	procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0	0.0	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.0	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.0	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.1	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0070728	leucine binding(GO:0070728)
0.0	0.1	GO:0005313	L-glutamate transmembrane transporter activity(GO:0005313)
0.0	0.0	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.0	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.0	GO:0038064	collagen receptor activity(GO:0038064)
0.0	0.0	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:0017151	DEAD/H-box RNA helicase binding(GO:0017151)
0.0	0.1	GO:0001972	retinoic acid binding(GO:0001972)
0.0	0.2	GO:0015924	mannosyl-oligosaccharide mannosidase activity(GO:0015924)
0.0	0.0	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)
0.0	0.3	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.0	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.0	GO:0016615	malate dehydrogenase activity(GO:0016615)
0.0	0.1	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0004556	alpha-amylase activity(GO:0004556)
0.0	0.0	GO:0030619	U1 snRNA binding(GO:0030619)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.1	GO:0017166	vinculin binding(GO:0017166)
0.0	0.0	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.0	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	PID IL6 7 PATHWAY	IL6-mediated signaling events
0.3	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.3	PID IL1 PATHWAY	IL1-mediated signaling events
0.2	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2	PID WNT CANONICAL PATHWAY	Canonical Wnt signaling pathway
0.7	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.3	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.4	REACTOME BILE ACID AND BILE SALT METABOLISM	Genes involved in Bile acid and bile salt metabolism
0.2	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.3	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.3	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.2	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.1	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.1	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.4	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.1	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.0	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	REACTOME SHC RELATED EVENTS	Genes involved in SHC-related events
0.1	REACTOME UNWINDING OF DNA	Genes involved in Unwinding of DNA
0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.1	REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS	Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.2	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.3	REACTOME IRON UPTAKE AND TRANSPORT	Genes involved in Iron uptake and transport
0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle

Results for Hoxd8

Z-value: 1.11

Motif logo

Transcription factors associated with Hoxd8

Activity of the Hoxd8 motif across conditions

Conditions sorted by the z-value of the Hoxd8 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hoxd8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: