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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Hsf1

Z-value: 1.99

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Transcription factors associated with Hsf1

Gene Symbol	Gene ID	Gene Info
Hsf1 Ensembl NCBI MGI UniProt	ENSMUSG00000022556.9	heat shock factor 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr15_76477583_76477960	Hsf1	85	0.838651	-0.76	7.9e-02	Click!
chr15_76478000_76478246	Hsf1	437	0.543659	-0.75	8.8e-02	Click!
chr15_76477284_76477443	Hsf1	59	0.516696	0.67	1.4e-01	Click!
chr15_76480940_76481264	Hsf1	3416	0.097576	-0.38	4.6e-01	Click!

Activity of the Hsf1 motif across conditions

Conditions sorted by the z-value of the Hsf1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_7199193_7199344	3.88	Igfbp1	insulin-like growth factor binding protein 1	1486	0.37
chr7_43440689_43440840	3.27	Cldnd2	claudin domain containing 2	18	0.92
chr10_41992198_41992354	2.76	Armc2	armadillo repeat containing 2	890	0.62
chr2_144182222_144182616	2.35	Gm5535	predicted gene 5535	3333	0.2
chr11_82948457_82948616	2.21	Slfn5	schlafen 5	2813	0.11
chr6_128493697_128493874	1.98	Pzp	PZP, alpha-2-macroglobulin like	1438	0.23
chr5_90424675_90424898	1.82	Gm43363	predicted gene 43363	27513	0.13
chr8_116344914_116345106	1.82	1700018P08Rik	RIKEN cDNA 1700018P08 gene	12051	0.29
chr6_136419356_136419519	1.76	Gm25882	predicted gene, 25882	1625	0.3
chr8_89311386_89311545	1.76	Gm5356	predicted pseudogene 5356	123905	0.06
chr15_25942169_25942359	1.76	Retreg1	reticulophagy regulator 1	415	0.85
chr5_135118877_135119300	1.73	Gm43500	predicted gene 43500	4205	0.12
chr10_61313715_61314040	1.72	Rpl27a-ps1	ribosomal protein L27A, pseudogene 1	4047	0.16
chr5_52309795_52309946	1.72	Gm43179	predicted gene 43179	32490	0.12
chr8_70634514_70634904	1.64	Gdf15	growth differentiation factor 15	2253	0.14
chr12_24615310_24615477	1.61	Gm6969	predicted pseudogene 6969	23617	0.13
chr19_61057398_61057702	1.58	Gm22520	predicted gene, 22520	44005	0.12
chr15_63364555_63364706	1.53	Gm41335	predicted gene, 41335	7611	0.27
chr12_100089427_100089592	1.46	4930477G07Rik	RIKEN cDNA 4930477G07 gene	7709	0.15
chr9_102864196_102864634	1.44	Ryk	receptor-like tyrosine kinase	4651	0.18
chr7_66196612_66196796	1.43	Gm45080	predicted gene 45080	6149	0.17
chr12_3862523_3862680	1.43	Dnmt3aos	DNA methyltransferase 3A, opposite strand	357	0.82
chr12_83582014_83582393	1.42	Zfyve1	zinc finger, FYVE domain containing 1	13484	0.14
chr2_133495524_133495962	1.41	Gm14100	predicted gene 14100	32625	0.16
chr5_112956750_112957247	1.41	Grk3	G protein-coupled receptor kinase 3	31200	0.15
chr13_18868301_18868479	1.39	Vps41	VPS41 HOPS complex subunit	23527	0.19
chr5_66165832_66165983	1.38	Gm22929	predicted gene, 22929	1245	0.3
chr3_135605510_135605876	1.37	Nfkb1	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	1834	0.34
chr6_128485251_128485402	1.37	Pzp	PZP, alpha-2-macroglobulin like	2529	0.14
chr8_126832324_126832475	1.36	A630001O12Rik	RIKEN cDNA A630001O12 gene	6834	0.22
chr15_73535998_73536192	1.28	Dennd3	DENN/MADD domain containing 3	11961	0.18
chr17_86779499_86780092	1.28	Gm50008	predicted gene, 50008	6525	0.19
chr10_68248229_68248529	1.25	Arid5b	AT rich interactive domain 5B (MRF1-like)	30342	0.19
chr4_105261100_105261481	1.24	Plpp3	phospholipid phosphatase 3	103943	0.07
chr12_35418013_35418379	1.23	Gm26071	predicted gene, 26071	22994	0.21
chr5_135479247_135479465	1.23	Gm42731	predicted gene 42731	5937	0.16
chr9_77707832_77708042	1.22	Gm47789	predicted gene, 47789	55	0.97
chr2_35338418_35338609	1.21	Stom	stomatin	1537	0.27
chr7_105596543_105596888	1.20	Hpx	hemopexin	3397	0.12
chr9_107576082_107576366	1.18	Hyal1	hyaluronoglucosaminidase 1	703	0.32
chr2_167324318_167324524	1.17	B4galt5	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5	10521	0.18
chr13_32492661_32492824	1.12	Gm48073	predicted gene, 48073	43673	0.17
chr2_101827994_101828363	1.12	Prr5l	proline rich 5 like	10802	0.22
chr2_62655069_62655412	1.11	Ifih1	interferon induced with helicase C domain 1	8985	0.18
chr1_191803404_191803597	1.11	Gm20203	predicted gene, 20203	12186	0.13
chr2_174858524_174858697	1.10	Gm14616	predicted gene 14616	2321	0.26
chr2_153694524_153694737	1.09	Dnmt3c	DNA methyltransferase 3C	2022	0.27
chr2_172511032_172511203	1.09	Gm14303	predicted gene 14303	1426	0.37
chr11_79725104_79725267	1.08	Mir365-2	microRNA 365-2	1215	0.37
chr9_122028437_122028754	1.08	Gm47117	predicted gene, 47117	16455	0.1
chr16_30258016_30258167	1.07	Gm49645	predicted gene, 49645	2939	0.19
chr2_80502470_80502665	1.06	Gm13687	predicted gene 13687	3337	0.2
chr2_35496007_35496180	1.06	Gm13445	predicted gene 13445	4574	0.15
chr10_8228115_8228580	1.05	Gm30906	predicted gene, 30906	52216	0.15
chr12_41451963_41452119	1.02	Lrrn3	leucine rich repeat protein 3, neuronal	34390	0.15
chr19_55087908_55088315	1.00	Gpam	glycerol-3-phosphate acyltransferase, mitochondrial	11340	0.21
chr13_98956568_98956727	1.00	Gm35215	predicted gene, 35215	10731	0.12
chr5_74784041_74784346	1.00	Gm42575	predicted gene 42575	34311	0.15
chr4_137890706_137890863	0.98	Gm13012	predicted gene 13012	6847	0.21
chr4_155566693_155567032	0.98	Nadk	NAD kinase	2790	0.15
chr1_72830155_72830306	0.97	Igfbp2	insulin-like growth factor binding protein 2	4908	0.25
chr1_136686557_136686994	0.95	Gm19705	predicted gene, 19705	3146	0.18
chr16_24482781_24482948	0.95	Lpp	LIM domain containing preferred translocation partner in lipoma	34773	0.16
chr13_48572250_48572425	0.95	Gm25232	predicted gene, 25232	47	0.95
chr15_34510659_34511041	0.95	Pop1	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)	943	0.43
chr3_31394556_31394733	0.95	Gm38025	predicted gene, 38025	53632	0.14
chr5_16470797_16470948	0.95	Gm8984	predicted gene 8984	38311	0.17
chr8_36609265_36609450	0.94	Dlc1	deleted in liver cancer 1	4517	0.32
chr2_59726132_59726380	0.92	Tanc1	tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1	16546	0.26
chr4_150665601_150665815	0.90	Gm16079	predicted gene 16079	13084	0.18
chr3_57604930_57605098	0.89	Mir6377	microRNA 6377	11595	0.12
chr14_76179509_76179660	0.89	Rps2-ps6	ribosomal protein S2, pseudogene 6	57961	0.11
chr11_86257735_86257956	0.89	Ints2	integrator complex subunit 2	270	0.91
chr1_46908404_46908555	0.89	Gm28527	predicted gene 28527	11600	0.18
chr15_77410201_77410378	0.89	Apol9a	apolipoprotein L 9a	738	0.48
chr11_57981089_57981255	0.88	Gm12249	predicted gene 12249	8038	0.16
chr8_119824884_119825204	0.87	Cotl1	coactosin-like 1 (Dictyostelium)	2327	0.27
chr15_51888034_51888200	0.87	Gm34678	predicted gene, 34678	3834	0.19
chr15_7138595_7138765	0.87	Lifr	LIF receptor alpha	1862	0.47
chr18_10826881_10827044	0.85	Mib1	mindbomb E3 ubiquitin protein ligase 1	28597	0.11
chr18_20279203_20279365	0.85	Dsg1a	desmoglein 1 alpha	31527	0.17
chr5_112281749_112281914	0.85	Tpst2	protein-tyrosine sulfotransferase 2	5124	0.13
chr10_39451218_39451393	0.84	Fyn	Fyn proto-oncogene	3500	0.26
chr4_136123469_136123639	0.83	Gm26001	predicted gene, 26001	13942	0.13
chr18_60891316_60891467	0.83	Arsi	arylsulfatase i	20389	0.13
chr17_29323723_29323898	0.83	Gm46603	predicted gene, 46603	1261	0.28
chr7_144038114_144038283	0.83	Shank2	SH3 and multiple ankyrin repeat domains 2	6934	0.21
chr17_85052584_85052811	0.83	Slc3a1	solute carrier family 3, member 1	24321	0.15
chr1_13236210_13236392	0.82	Gm37409	predicted gene, 37409	133	0.95
chr10_80255545_80256082	0.82	Ndufs7	NADH:ubiquinone oxidoreductase core subunit S7	2498	0.11
chr12_7983690_7984451	0.82	Apob	apolipoprotein B	6291	0.23
chr8_109970299_109970623	0.81	Gm45795	predicted gene 45795	3891	0.15
chr6_121880801_121881009	0.81	Mug1	murinoglobulin 1	4672	0.22
chr17_86761972_86762144	0.81	Epas1	endothelial PAS domain protein 1	8358	0.18
chr15_55266394_55266563	0.80	Gm26296	predicted gene, 26296	3875	0.27
chr7_35131018_35131347	0.80	Gm35665	predicted gene, 35665	10267	0.1
chr5_146976747_146977100	0.79	Mtif3	mitochondrial translational initiation factor 3	13123	0.16
chr6_117276510_117276795	0.79	Rpl28-ps4	ribosomal protein L28, pseudogene 4	62586	0.12
chr7_142622273_142622480	0.78	Gm33148	predicted gene, 33148	30632	0.08
chr11_113076302_113076554	0.77	2610035D17Rik	RIKEN cDNA 2610035D17 gene	96649	0.08
chr15_82422998_82423175	0.76	Gm19267	predicted gene, 19267	361	0.65
chr8_70531884_70532043	0.75	Fkbp8	FK506 binding protein 8	158	0.89
chr13_41019879_41020036	0.75	Tmem14c	transmembrane protein 14C	3665	0.15
chr10_61337527_61337708	0.75	Pald1	phosphatase domain containing, paladin 1	4710	0.15
chr15_81399706_81399886	0.75	St13	suppression of tumorigenicity 13	202	0.64
chr3_30934508_30934659	0.75	Phc3	polyhomeotic 3	1472	0.36
chr10_87030552_87030730	0.74	Stab2	stabilin 2	22616	0.14
chr7_28867571_28867753	0.74	Lgals7	lectin, galactose binding, soluble 7	3207	0.11
chr7_30968614_30968895	0.74	Lsr	lipolysis stimulated lipoprotein receptor	4568	0.08
chr18_11915892_11916043	0.74	Gm49968	predicted gene, 49968	2836	0.3
chr1_55088026_55088196	0.74	Hspe1	heat shock protein 1 (chaperonin 10)	21	0.55
chr9_40801064_40801254	0.74	Hspa8	heat shock protein 8	117	0.91
chrX_20829007_20829192	0.73	Gm24824	predicted gene, 24824	5285	0.12
chr5_92674843_92675048	0.73	Ccdc158	coiled-coil domain containing 158	180	0.94
chr2_31455583_31455753	0.73	Hmcn2	hemicentin 2	960	0.57
chr1_54006103_54006274	0.71	Gm24251	predicted gene, 24251	119247	0.05
chr16_30827849_30828032	0.71	Gm26295	predicted gene, 26295	13778	0.14
chr13_45891782_45891969	0.71	Atxn1	ataxin 1	19587	0.21
chr1_164215221_164215636	0.70	Slc19a2	solute carrier family 19 (thiamine transporter), member 2	33618	0.11
chr5_130768145_130768304	0.69	Gm23761	predicted gene, 23761	14477	0.25
chr8_121583597_121583942	0.69	Gm17786	predicted gene, 17786	2004	0.19
chr10_75160838_75161062	0.68	Bcr	BCR activator of RhoGEF and GTPase	590	0.78
chr5_66579243_66579412	0.68	C530043K16Rik	RIKEN cDNA C530043K16 gene	16243	0.15
chr4_149922172_149922323	0.67	Spsb1	splA/ryanodine receptor domain and SOCS box containing 1	224	0.92
chr5_65351142_65351385	0.67	Klb	klotho beta	2855	0.16
chr4_47151808_47151959	0.67	Gm12423	predicted gene 12423	19786	0.15
chr1_134163496_134163749	0.66	Chil1	chitinase-like 1	18554	0.12
chr9_66276951_66277383	0.64	Dapk2	death-associated protein kinase 2	8793	0.23
chr7_141460493_141460686	0.64	Cracr2b	calcium release activated channel regulator 2B	505	0.5
chr19_10122021_10122209	0.64	Fads2	fatty acid desaturase 2	20369	0.12
chr7_130246644_130247139	0.64	Fgfr2	fibroblast growth factor receptor 2	14966	0.26
chr7_28334687_28334838	0.63	Supt5	suppressor of Ty 5, DSIF elongation factor subunit	3308	0.1
chr16_23293902_23294209	0.63	St6gal1	beta galactoside alpha 2,6 sialyltransferase 1	3585	0.22
chr11_77371279_77371455	0.63	Ssh2	slingshot protein phosphatase 2	20070	0.17
chr13_94250295_94250470	0.62	Scamp1	secretory carrier membrane protein 1	3824	0.21
chr9_73105883_73106055	0.62	Khdc3	KH domain containing 3, subcortical maternal complex member	3459	0.12
chr7_135254550_135254751	0.62	Nps	neuropeptide S	4053	0.24
chr1_180402576_180402752	0.62	Gm36933	predicted gene, 36933	26220	0.12
chr9_48746335_48746564	0.62	Zbtb16	zinc finger and BTB domain containing 16	89496	0.08
chr15_82547824_82547987	0.61	Gm28023	predicted gene, 28023	747	0.37
chr12_21183267_21183628	0.61	AC156032.1		63876	0.08
chr16_22951195_22951399	0.61	Hrg	histidine-rich glycoprotein	197	0.91
chr1_156986305_156986506	0.61	4930439D14Rik	RIKEN cDNA 4930439D14 gene	46567	0.11
chr17_31401280_31401456	0.60	Pde9a	phosphodiesterase 9A	12788	0.13
chr9_31145374_31145534	0.60	Aplp2	amyloid beta (A4) precursor-like protein 2	8191	0.17
chr10_79838143_79838304	0.60	Misp	mitotic spindle positioning	8937	0.06
chrX_136742828_136742985	0.59	Morf4l2	mortality factor 4 like 2	12	0.54
chr9_54918904_54919072	0.59	Hykk	hydroxylysine kinase 1	1641	0.29
chr13_37649588_37649765	0.59	Gm40916	predicted gene, 40916	1440	0.29
chr10_20673746_20674078	0.59	Gm17230	predicted gene 17230	48277	0.14
chr13_23683913_23684244	0.59	H2bc4	H2B clustered histone 4	121	0.45
chr15_78448062_78448253	0.59	Tmprss6	transmembrane serine protease 6	3778	0.12
chr2_114775396_114775571	0.59	Gm13975	predicted gene 13975	67371	0.11
chr11_44156189_44156382	0.59	Gm12154	predicted gene 12154	110924	0.06
chr11_29808774_29809133	0.58	Eml6	echinoderm microtubule associated protein like 6	5854	0.17
chr1_58237983_58238146	0.58	Aox4	aldehyde oxidase 4	2542	0.27
chr8_11323805_11323964	0.58	Col4a1	collagen, type IV, alpha 1	11058	0.16
chr8_117723783_117723934	0.58	Hsd17b2	hydroxysteroid (17-beta) dehydrogenase 2	2922	0.19
chr16_34949305_34949469	0.58	Mylk	myosin, light polypeptide kinase	3671	0.21
chr2_158734851_158735002	0.58	Gm26141	predicted gene, 26141	5212	0.19
chr11_110167486_110168045	0.57	Abca9	ATP-binding cassette, sub-family A (ABC1), member 9	290	0.93
chr2_34977060_34977295	0.57	Gm13450	predicted gene 13450	12273	0.11
chr9_61810010_61810175	0.57	Gm19208	predicted gene, 19208	41612	0.15
chr12_28670841_28670992	0.57	Adi1	acireductone dioxygenase 1	4315	0.15
chr17_73131950_73132101	0.56	Lclat1	lysocardiolipin acyltransferase 1	5598	0.24
chr8_126903217_126903593	0.56	Gm31718	predicted gene, 31718	4810	0.2
chr2_167886467_167886618	0.56	Gm14319	predicted gene 14319	27957	0.14
chr8_126586607_126587402	0.55	Irf2bp2	interferon regulatory factor 2 binding protein 2	6982	0.23
chr13_107841338_107841500	0.55	Gm22118	predicted gene, 22118	12139	0.24
chr4_46913567_46913730	0.55	Gabbr2	gamma-aminobutyric acid (GABA) B receptor, 2	53746	0.13
chr3_153930744_153930906	0.54	Acadm	acyl-Coenzyme A dehydrogenase, medium chain	683	0.51
chr10_7142433_7142596	0.54	Cnksr3	Cnksr family member 3	7008	0.29
chr17_27969528_27969712	0.54	Gm15597	predicted gene 15597	4304	0.14
chr9_85568984_85569135	0.53	Gm48834	predicted gene, 48834	15294	0.22
chr6_94729670_94729855	0.53	Lrig1	leucine-rich repeats and immunoglobulin-like domains 1	29604	0.17
chr3_53372078_53372254	0.53	Gm43472	predicted gene 43472	24937	0.15
chr3_57428830_57429005	0.52	Tm4sf4	transmembrane 4 superfamily member 4	3603	0.27
chr5_109557797_109558252	0.52	Crlf2	cytokine receptor-like factor 2	912	0.5
chr7_145047841_145048023	0.52	Ccnd1	cyclin D1	108007	0.05
chr6_145360771_145361132	0.52	Gm23498	predicted gene, 23498	5907	0.15
chr19_7040189_7040358	0.52	Stip1	stress-induced phosphoprotein 1	306	0.79
chr7_71232911_71233088	0.52	6030442E23Rik	RIKEN cDNA 6030442E23 gene	15950	0.2
chr16_38618378_38618532	0.52	Tmem39a	transmembrane protein 39a	30416	0.13
chrX_73715619_73715775	0.52	Bcap31	B cell receptor associated protein 31	478	0.57
chr5_151312471_151312634	0.51	Gm7041	predicted gene 7041	31429	0.15
chr19_7039938_7040112	0.51	Stip1	stress-induced phosphoprotein 1	58	0.94
chr18_84854418_84854822	0.51	Cyb5a	cytochrome b5 type A (microsomal)	349	0.85
chr18_46636342_46636847	0.51	Gm3734	predicted gene 3734	5787	0.17
chr6_129097928_129098079	0.50	Clec2e	C-type lectin domain family 2, member e	2910	0.16
chr6_72279240_72279429	0.50	Sftpb	surfactant associated protein B	25276	0.11
chr7_141327534_141327875	0.50	Deaf1	DEAF1, transcription factor	14	0.5
chr10_80826930_80827098	0.50	Oaz1	ornithine decarboxylase antizyme 1	321	0.7
chr8_115823982_115824181	0.50	Maf	avian musculoaponeurotic fibrosarcoma oncogene homolog	116287	0.06
chr2_6129018_6129180	0.50	Proser2	proline and serine rich 2	1040	0.45
chr2_36243894_36244091	0.50	Ptgs1	prostaglandin-endoperoxide synthase 1	1517	0.27
chr7_19793257_19793455	0.50	Cblc	Casitas B-lineage lymphoma c	140	0.89
chr7_123192367_123192758	0.50	Tnrc6a	trinucleotide repeat containing 6a	12641	0.2
chr19_30207260_30207548	0.49	Mbl2	mannose-binding lectin (protein C) 2	25538	0.16
chr1_88282912_88283223	0.49	Trpm8	transient receptor potential cation channel, subfamily M, member 8	5406	0.12
chr9_56418511_56418671	0.49	Hmg20a	high mobility group 20A	18	0.9

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.2	GO:0061083	regulation of protein refolding(GO:0061083)
0.2	0.6	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.2	0.5	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.2	0.5	GO:1903416	response to glycoside(GO:1903416)
0.1	0.5	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.1	0.4	GO:1900104	hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.1	0.3	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.1	0.5	GO:1903626	positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.1	0.3	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1	0.4	GO:0035799	ureter maturation(GO:0035799)
0.1	0.3	GO:0006741	NADP biosynthetic process(GO:0006741)
0.1	0.3	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.1	0.4	GO:0048625	myoblast fate commitment(GO:0048625)
0.1	0.3	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.1	0.3	GO:0044829	positive regulation by host of viral genome replication(GO:0044829)
0.1	0.4	GO:0071865	regulation of apoptotic process in bone marrow(GO:0071865) negative regulation of apoptotic process in bone marrow(GO:0071866)
0.1	1.8	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.1	0.2	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.1	0.3	GO:0003433	chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.1	0.4	GO:0016078	tRNA catabolic process(GO:0016078)
0.1	0.3	GO:0090206	negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.1	0.2	GO:0032776	DNA methylation on cytosine within a CG sequence(GO:0010424) DNA methylation on cytosine(GO:0032776)
0.1	0.2	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.2	GO:0000711	meiotic DNA repair synthesis(GO:0000711)
0.1	0.2	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.1	0.2	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.1	0.3	GO:0044791	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.1	0.5	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.1	0.6	GO:0051085	chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1	0.3	GO:0039530	MDA-5 signaling pathway(GO:0039530)
0.1	0.2	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.1	0.3	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.1	0.4	GO:0008063	Toll signaling pathway(GO:0008063)
0.1	0.2	GO:0061643	chemorepulsion of axon(GO:0061643)
0.1	0.1	GO:0032672	regulation of interleukin-3 production(GO:0032672)
0.1	0.4	GO:2001256	regulation of store-operated calcium entry(GO:2001256)
0.1	0.2	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.1	0.2	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	0.3	GO:1902774	late endosome to lysosome transport(GO:1902774)
0.1	0.3	GO:0009115	xanthine catabolic process(GO:0009115)
0.1	0.8	GO:0016180	snRNA processing(GO:0016180)
0.0	0.1	GO:0015772	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.2	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.1	GO:0010255	carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255)
0.0	0.3	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
0.0	0.1	GO:0060737	prostate gland morphogenetic growth(GO:0060737)
0.0	0.2	GO:0097278	complement-dependent cytotoxicity(GO:0097278)
0.0	0.1	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.1	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.0	0.3	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.2	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.1	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.6	GO:0050872	white fat cell differentiation(GO:0050872)
0.0	0.2	GO:0052428	negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0	0.1	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.0	0.5	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.0	0.1	GO:0071596	ubiquitin-dependent protein catabolic process via the N-end rule pathway(GO:0071596)
0.0	0.1	GO:0060750	epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0	0.2	GO:0010841	positive regulation of circadian sleep/wake cycle, wakefulness(GO:0010841)
0.0	0.1	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.3	GO:0035745	T-helper 2 cell cytokine production(GO:0035745)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.0	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.2	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.0	0.3	GO:0055091	phospholipid homeostasis(GO:0055091)
0.0	0.1	GO:0060332	positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
0.0	0.1	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.2	GO:0034374	low-density lipoprotein particle remodeling(GO:0034374)
0.0	0.1	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:0043134	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0	0.1	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.2	GO:0060414	aorta smooth muscle tissue morphogenesis(GO:0060414)
0.0	0.1	GO:0000480	endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0	0.1	GO:0015888	thiamine transport(GO:0015888)
0.0	0.1	GO:0070562	regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0	0.1	GO:0060672	epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.1	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.2	GO:0002002	regulation of angiotensin levels in blood(GO:0002002)
0.0	0.3	GO:0001771	immunological synapse formation(GO:0001771)
0.0	0.1	GO:0051031	tRNA transport(GO:0051031)
0.0	0.1	GO:0051665	membrane raft localization(GO:0051665)
0.0	0.1	GO:1903336	negative regulation of vacuolar transport(GO:1903336)
0.0	0.1	GO:0009233	menaquinone metabolic process(GO:0009233)
0.0	0.2	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	0.2	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.1	GO:0042758	long-chain fatty acid catabolic process(GO:0042758)
0.0	0.1	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.3	GO:0042523	regulation of tyrosine phosphorylation of Stat5 protein(GO:0042522) positive regulation of tyrosine phosphorylation of Stat5 protein(GO:0042523)
0.0	0.3	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.7	GO:0021904	dorsal/ventral neural tube patterning(GO:0021904)
0.0	0.1	GO:1901164	negative regulation of trophoblast cell migration(GO:1901164)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.0	0.3	GO:0001553	luteinization(GO:0001553)
0.0	0.1	GO:0071033	nuclear retention of pre-mRNA at the site of transcription(GO:0071033)
0.0	0.1	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.0	0.0	GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0	0.1	GO:0002017	regulation of blood volume by renal aldosterone(GO:0002017)
0.0	0.2	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.2	GO:0002934	desmosome organization(GO:0002934)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.1	GO:0016561	protein import into peroxisome matrix, translocation(GO:0016561)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0070366	regulation of hepatocyte differentiation(GO:0070366)
0.0	0.1	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.0	0.2	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0	0.1	GO:1903288	regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.0	0.2	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:1902414	protein localization to cell junction(GO:1902414)
0.0	0.1	GO:0061030	epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.1	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:0090080	positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080)
0.0	0.3	GO:0043968	histone H2A acetylation(GO:0043968)
0.0	0.0	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.1	GO:1902947	regulation of tau-protein kinase activity(GO:1902947)
0.0	0.0	GO:0030397	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:0021873	forebrain neuroblast division(GO:0021873)
0.0	0.1	GO:0006548	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0070669	response to interleukin-2(GO:0070669)
0.0	0.1	GO:0035814	negative regulation of renal sodium excretion(GO:0035814)
0.0	0.0	GO:1904180	negative regulation of membrane depolarization(GO:1904180)
0.0	0.2	GO:0051988	regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.0	0.1	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0	0.1	GO:0043504	mitochondrial DNA repair(GO:0043504)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.2	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.2	GO:0051895	negative regulation of focal adhesion assembly(GO:0051895)
0.0	0.1	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.1	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0	0.0	GO:0019859	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.2	GO:0071625	vocalization behavior(GO:0071625)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.0	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0002525	acute inflammatory response to non-antigenic stimulus(GO:0002525)
0.0	0.1	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.1	GO:0015691	cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0	0.1	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.1	GO:0042790	transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.0	0.0	GO:0060462	lung lobe development(GO:0060462) lung lobe morphogenesis(GO:0060463)
0.0	0.0	GO:0055099	response to high density lipoprotein particle(GO:0055099)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.3	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.0	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.1	GO:1904526	regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.0	0.4	GO:0010762	regulation of fibroblast migration(GO:0010762)
0.0	0.0	GO:0032988	ribonucleoprotein complex disassembly(GO:0032988)
0.0	0.1	GO:0072307	metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0	0.0	GO:2000611	positive regulation of thyroid hormone generation(GO:2000611)
0.0	0.0	GO:1903275	positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.0	0.0	GO:0002432	granuloma formation(GO:0002432)
0.0	0.0	GO:0035754	B cell chemotaxis(GO:0035754)
0.0	0.2	GO:0007097	nuclear migration(GO:0007097)
0.0	0.0	GO:0009629	response to gravity(GO:0009629)
0.0	0.0	GO:0033029	regulation of neutrophil apoptotic process(GO:0033029) negative regulation of neutrophil apoptotic process(GO:0033030)
0.0	0.0	GO:0023021	termination of signal transduction(GO:0023021)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0070814	hydrogen sulfide biosynthetic process(GO:0070814)
0.0	0.2	GO:0045898	regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.2	GO:0006030	chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
0.0	0.0	GO:1905216	positive regulation of mRNA binding(GO:1902416) positive regulation of RNA binding(GO:1905216)
0.0	0.1	GO:0006477	protein sulfation(GO:0006477)
0.0	0.0	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.0	0.0	GO:0008355	olfactory learning(GO:0008355)
0.0	0.0	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.0	GO:0042427	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0	0.0	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0	0.1	GO:0010992	ubiquitin homeostasis(GO:0010992)
0.0	0.2	GO:0050832	defense response to fungus(GO:0050832)
0.0	0.2	GO:0003094	glomerular filtration(GO:0003094)
0.0	0.1	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0008054	negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054)
0.0	0.1	GO:2000270	negative regulation of fibroblast apoptotic process(GO:2000270)
0.0	0.2	GO:0044065	regulation of respiratory system process(GO:0044065)
0.0	0.1	GO:0050955	thermoception(GO:0050955)
0.0	0.0	GO:0071503	response to heparin(GO:0071503) cellular response to heparin(GO:0071504)
0.0	0.2	GO:2000651	positive regulation of sodium ion transmembrane transporter activity(GO:2000651)
0.0	0.1	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.2	GO:0051818	disruption of cells of other organism involved in symbiotic interaction(GO:0051818) killing of cells in other organism involved in symbiotic interaction(GO:0051883)
0.0	0.0	GO:0043137	DNA replication, removal of RNA primer(GO:0043137)
0.0	0.1	GO:0007176	regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0	0.0	GO:1990791	dorsal root ganglion development(GO:1990791)
0.0	0.0	GO:0072223	metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.0	0.1	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0	0.0	GO:0030214	hyaluronan catabolic process(GO:0030214)
0.0	0.0	GO:0070671	response to interleukin-12(GO:0070671)
0.0	0.1	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	0.0	GO:1900378	positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0	0.1	GO:0033133	positive regulation of glucokinase activity(GO:0033133)
0.0	0.0	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.0	0.1	GO:0046689	response to mercury ion(GO:0046689)
0.0	0.0	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.0	GO:1902307	positive regulation of sodium ion transmembrane transport(GO:1902307)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.2	GO:0045780	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	0.0	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0	0.0	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.2	GO:0050732	negative regulation of peptidyl-tyrosine phosphorylation(GO:0050732)
0.0	0.0	GO:0043928	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.0	0.0	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.0	GO:0070314	G1 to G0 transition(GO:0070314)
0.0	0.0	GO:0014858	positive regulation of skeletal muscle cell proliferation(GO:0014858)
0.0	0.0	GO:2000653	regulation of genetic imprinting(GO:2000653)
0.0	0.3	GO:0031440	regulation of mRNA 3'-end processing(GO:0031440)
0.0	0.1	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
0.0	0.0	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.0	0.1	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:0014717	regulation of satellite cell activation involved in skeletal muscle regeneration(GO:0014717) satellite cell activation involved in skeletal muscle regeneration(GO:0014901)
0.0	0.5	GO:0007566	embryo implantation(GO:0007566)
0.0	0.1	GO:0048268	clathrin coat assembly(GO:0048268)
0.0	0.1	GO:0061050	regulation of cell growth involved in cardiac muscle cell development(GO:0061050)
0.0	0.0	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
0.0	0.0	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.0	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.0	GO:0010957	negative regulation of vitamin D biosynthetic process(GO:0010957)
0.0	0.1	GO:1902510	regulation of apoptotic DNA fragmentation(GO:1902510)
0.0	0.1	GO:2000288	positive regulation of myoblast proliferation(GO:2000288)
0.0	0.0	GO:0060214	endocardium formation(GO:0060214)
0.0	0.1	GO:0045974	negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0	0.1	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	0.0	GO:0006203	dGTP catabolic process(GO:0006203)
0.0	0.0	GO:0051133	regulation of NK T cell activation(GO:0051133) positive regulation of NK T cell activation(GO:0051135)
0.0	0.0	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.0	GO:0035188	blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
0.0	0.1	GO:1901727	positive regulation of histone deacetylase activity(GO:1901727)
0.0	0.0	GO:0051799	negative regulation of hair follicle development(GO:0051799)
0.0	0.0	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.0	GO:0045578	negative regulation of B cell differentiation(GO:0045578)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.3	GO:0006284	base-excision repair(GO:0006284)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0032010	phagolysosome(GO:0032010)
0.1	0.4	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.1	0.5	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1	0.7	GO:0043202	lysosomal lumen(GO:0043202)
0.1	0.3	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.1	0.3	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.1	0.8	GO:0032039	integrator complex(GO:0032039)
0.1	0.3	GO:0044194	cytolytic granule(GO:0044194)
0.1	0.4	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.1	0.2	GO:0005726	perichromatin fibrils(GO:0005726)
0.1	0.3	GO:0000138	Golgi trans cisterna(GO:0000138)
0.1	0.2	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.2	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.2	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.2	GO:0005587	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.1	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.3	GO:0033263	CORVET complex(GO:0033263)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.2	GO:0031415	NatA complex(GO:0031415)
0.0	0.2	GO:0000801	central element(GO:0000801)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:1990761	growth cone lamellipodium(GO:1990761)
0.0	0.4	GO:0038201	TOR complex(GO:0038201)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.2	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.1	GO:0042585	germinal vesicle(GO:0042585)
0.0	0.1	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0	0.1	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.6	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.1	GO:0019815	B cell receptor complex(GO:0019815)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.1	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.2	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.3	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.1	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.2	GO:0031595	nuclear proteasome complex(GO:0031595)
0.0	0.1	GO:0005971	ribonucleoside-diphosphate reductase complex(GO:0005971)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.2	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.1	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.0	0.1	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.2	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.1	GO:0030478	actin cap(GO:0030478)
0.0	0.3	GO:1902562	NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0	0.0	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.7	GO:0005876	spindle microtubule(GO:0005876)
0.0	0.1	GO:0031209	SCAR complex(GO:0031209)
0.0	0.1	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.1	GO:0016012	sarcoglycan complex(GO:0016012)
0.0	0.1	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.1	GO:0071541	eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.0	GO:0031092	platelet alpha granule membrane(GO:0031092)
0.0	0.0	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0	0.0	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.0	GO:0005767	secondary lysosome(GO:0005767)
0.0	0.1	GO:0000813	ESCRT I complex(GO:0000813)
0.0	0.1	GO:0032045	guanyl-nucleotide exchange factor complex(GO:0032045)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.1	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	2.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.2	0.7	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.2	0.5	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.4	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.1	0.6	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.1	0.3	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.1	0.4	GO:0032564	dATP binding(GO:0032564)
0.1	0.4	GO:0050501	hyaluronan synthase activity(GO:0050501)
0.1	0.2	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1	0.2	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.1	0.2	GO:0047276	N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.1	0.4	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.1	0.2	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.1	0.4	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.1	0.2	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.1	0.3	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1	0.3	GO:0042609	CD4 receptor binding(GO:0042609)
0.1	0.3	GO:0050897	cobalt ion binding(GO:0050897)
0.1	0.4	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.1	0.3	GO:0016726	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.0	0.1	GO:0015157	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.2	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.2	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.2	GO:0043559	insulin binding(GO:0043559)
0.0	0.3	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.2	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.4	GO:0070635	single-strand selective uracil DNA N-glycosylase activity(GO:0017065) nicotinamide riboside hydrolase activity(GO:0070635) nicotinic acid riboside hydrolase activity(GO:0070636) deoxyribonucleoside 5'-monophosphate N-glycosidase activity(GO:0070694)
0.0	0.1	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.0	0.2	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.2	GO:0070728	leucine binding(GO:0070728)
0.0	0.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.2	GO:0070991	medium-chain-acyl-CoA dehydrogenase activity(GO:0070991)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.2	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.2	GO:0035473	lipase binding(GO:0035473)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.0	GO:0030620	U2 snRNA binding(GO:0030620)
0.0	0.6	GO:0001784	phosphotyrosine binding(GO:0001784)
0.0	0.3	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0	0.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.1	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0015563	uptake transmembrane transporter activity(GO:0015563)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0036402	proteasome-activating ATPase activity(GO:0036402)
0.0	0.1	GO:0019211	phosphatase activator activity(GO:0019211)
0.0	0.1	GO:0048045	4-hydroxybenzoate octaprenyltransferase activity(GO:0008412) protoheme IX farnesyltransferase activity(GO:0008495) (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity(GO:0043888) cadaverine aminopropyltransferase activity(GO:0043918) agmatine aminopropyltransferase activity(GO:0043919) 1,4-dihydroxy-2-naphthoate octaprenyltransferase activity(GO:0046428) trans-pentaprenyltranstransferase activity(GO:0048045) ATP dimethylallyltransferase activity(GO:0052622) ADP dimethylallyltransferase activity(GO:0052623)
0.0	0.1	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.3	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.3	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.0	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.0	0.3	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.1	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.0	0.2	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.2	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.2	GO:0048027	mRNA 5'-UTR binding(GO:0048027)
0.0	0.1	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.2	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.4	GO:0042813	Wnt-activated receptor activity(GO:0042813)
0.0	0.4	GO:0005527	macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0	0.1	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.3	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.1	GO:0005131	growth hormone receptor binding(GO:0005131)
0.0	0.1	GO:0016728	ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.0	0.6	GO:0042805	actinin binding(GO:0042805)
0.0	1.3	GO:0051087	chaperone binding(GO:0051087)
0.0	0.1	GO:0102345	3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0	0.1	GO:0034902	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.1	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.0	GO:0030984	kininogen binding(GO:0030984)
0.0	0.1	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.5	GO:0035035	histone acetyltransferase binding(GO:0035035)
0.0	0.1	GO:0070698	type I activin receptor binding(GO:0070698)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.0	GO:0005094	Rho GDP-dissociation inhibitor activity(GO:0005094)
0.0	0.2	GO:0004568	chitinase activity(GO:0004568)
0.0	0.3	GO:0022829	wide pore channel activity(GO:0022829)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0008297	single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.4	GO:0051879	Hsp90 protein binding(GO:0051879)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)
0.0	0.2	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0001013	RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0	0.1	GO:1990226	histone methyltransferase binding(GO:1990226)
0.0	0.1	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.2	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.0	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.0	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.3	GO:0036002	pre-mRNA binding(GO:0036002)
0.0	0.1	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.0	GO:0004517	nitric-oxide synthase activity(GO:0004517)
0.0	0.1	GO:0070008	serine-type exopeptidase activity(GO:0070008)
0.0	0.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.1	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.1	GO:0003873	6-phosphofructo-2-kinase activity(GO:0003873)
0.0	0.2	GO:0008198	ferrous iron binding(GO:0008198)
0.0	0.0	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0	0.0	GO:0071208	histone pre-mRNA DCP binding(GO:0071208)
0.0	0.0	GO:0031708	endothelin B receptor binding(GO:0031708)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.0	GO:0034739	histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.0	0.6	GO:0004869	cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0	0.4	GO:0004177	aminopeptidase activity(GO:0004177)
0.0	0.0	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.2	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0010521	telomerase inhibitor activity(GO:0010521)
0.0	0.1	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.1	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	0.1	GO:0005520	insulin-like growth factor binding(GO:0005520)
0.0	0.1	GO:0031702	type 1 angiotensin receptor binding(GO:0031702)
0.0	0.2	GO:0070273	phosphatidylinositol-4-phosphate binding(GO:0070273)
0.0	0.1	GO:0048407	platelet-derived growth factor binding(GO:0048407)
0.0	0.1	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
0.0	0.1	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.2	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.1	GO:0035174	histone serine kinase activity(GO:0035174)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
2.1	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.4	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.4	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.3	PID AURORA A PATHWAY	Aurora A signaling
0.5	ST ERK1 ERK2 MAPK PATHWAY	ERK1/ERK2 MAPK Pathway
0.5	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.3	PID S1P S1P4 PATHWAY	S1P4 pathway
0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.1	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.7	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.5	NABA COLLAGENS	Genes encoding collagen proteins
0.1	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.5	PID FGF PATHWAY	FGF signaling pathway
0.2	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.2	PID FRA PATHWAY	Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.3	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.1	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.3	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.2	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.0	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	2.3	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	0.6	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.1	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.0	0.7	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.6	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.0	0.7	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants
0.0	0.3	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.5	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.3	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.4	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.3	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.4	REACTOME PROCESSING OF INTRONLESS PRE MRNAS	Genes involved in Processing of Intronless Pre-mRNAs
0.0	0.4	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.2	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.0	1.1	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.0	0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling
0.0	0.4	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.1	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.0	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.0	0.3	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.1	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.0	0.5	REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS	Genes involved in Apoptotic cleavage of cellular proteins
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.2	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.2	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.3	REACTOME FGFR LIGAND BINDING AND ACTIVATION	Genes involved in FGFR ligand binding and activation
0.0	0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.1	REACTOME ACYL CHAIN REMODELLING OF PE	Genes involved in Acyl chain remodelling of PE
0.0	0.9	REACTOME L1CAM INTERACTIONS	Genes involved in L1CAM interactions
0.0	0.3	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.0	0.3	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.0	0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.0	0.3	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.7	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.0	0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.5	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
0.0	0.1	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.5	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG

Results for Hsf1

Z-value: 1.99

Motif logo

Transcription factors associated with Hsf1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Hsf1 motif across conditions

Conditions sorted by the z-value of the Hsf1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Hsf1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: