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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Irf3

Z-value: 2.60

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Transcription factors associated with Irf3

Gene Symbol	Gene ID	Gene Info
Irf3 Ensembl NCBI MGI UniProt	ENSMUSG00000003184.8	interferon regulatory factor 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr7_45000808_45000995	Irf3	153	0.842730	0.84	3.7e-02	Click!
chr7_44997547_44997706	Irf3	22	0.496455	0.77	7.4e-02	Click!
chr7_44999841_45000005	Irf3	244	0.731095	0.60	2.1e-01	Click!
chr7_44997789_44998013	Irf3	48	0.774386	-0.41	4.2e-01	Click!
chr7_44998259_44998621	Irf3	114	0.665814	-0.09	8.7e-01	Click!

Activity of the Irf3 motif across conditions

Conditions sorted by the z-value of the Irf3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_129701203_129701458	7.19	Septin14	septin 14	2929	0.16
chr5_103592755_103593053	2.91	Gm15844	predicted gene 15844	31567	0.12
chr9_32906282_32906466	2.22	Gm27162	predicted gene 27162	22592	0.19
chr12_79532159_79532332	1.79	Rad51b	RAD51 paralog B	204892	0.02
chr14_31903760_31903916	1.52	D830044D21Rik	RIKEN cDNA D830044D21 gene	2690	0.29
chr5_36726541_36726703	1.45	Gm43701	predicted gene 43701	21996	0.11
chr2_72114198_72114385	1.43	Rapgef4	Rap guanine nucleotide exchange factor (GEF) 4	26420	0.18
chr5_106465177_106465353	1.43	Gm26872	predicted gene, 26872	5742	0.18
chr4_107285558_107285727	1.40	Gm12850	predicted gene 12850	15208	0.11
chr11_115199220_115199371	1.39	Nat9	N-acetyltransferase 9 (GCN5-related, putative)	11436	0.11
chr5_86118821_86118972	1.36	Stap1	signal transducing adaptor family member 1	32438	0.12
chr13_104116230_104116397	1.33	Sgtb	small glutamine-rich tetratricopeptide repeat (TPR)-containing, beta	6484	0.18
chr11_53423107_53423311	1.33	Leap2	liver-expressed antimicrobial peptide 2	39	0.94
chr8_115980743_115980903	1.33	Gm45733	predicted gene 45733	8752	0.32
chr8_116581400_116581581	1.29	Dynlrb2	dynein light chain roadblock-type 2	76475	0.1
chr8_46546530_46546687	1.24	Cenpu	centromere protein U	5420	0.17
chr11_65776990_65777160	1.19	Map2k4	mitogen-activated protein kinase kinase 4	11210	0.21
chr1_9876847_9876998	1.18	Sgk3	serum/glucocorticoid regulated kinase 3	6545	0.15
chr6_142752473_142752975	1.17	Cmas	cytidine monophospho-N-acetylneuraminic acid synthetase	3962	0.23
chr2_167062613_167062781	1.17	Znfx1	zinc finger, NFX1-type containing 1	19	0.72
chr14_45219045_45219298	1.14	Txndc16	thioredoxin domain containing 16	193	0.78
chr13_39441574_39441735	1.13	Gm47348	predicted gene, 47348	1089	0.53
chr9_34258652_34258813	1.12	Gm27161	predicted gene 27161	58504	0.15
chr7_104244343_104244526	1.11	Trim34a	tripartite motif-containing 34A	23	0.94
chr4_156200761_156200940	1.11	Isg15	ISG15 ubiquitin-like modifier	54	0.94
chr7_104353298_104353500	1.11	Trim12c	tripartite motif-containing 12C	37	0.94
chr9_14717790_14718063	1.09	Piwil4	piwi-like RNA-mediated gene silencing 4	547	0.6
chr11_48994173_48994324	1.09	Tgtp1	T cell specific GTPase 1	76	0.93
chr1_164252428_164252629	1.06	Slc19a2	solute carrier family 19 (thiamine transporter), member 2	3275	0.2
chr4_11147012_11147305	1.04	Gm11830	predicted gene 11830	2448	0.18
chr11_26413799_26413986	1.04	Gm12713	predicted gene 12713	4685	0.26
chr6_141333358_141333670	1.03	Gm10400	predicted gene 10400	7039	0.26
chr12_104230931_104231112	1.02	Gm8918	predicted gene 8918	1018	0.33
chr2_68434673_68434858	1.01	Stk39	serine/threonine kinase 39	37175	0.16
chr2_85047886_85048056	1.00	Tnks1bp1	tankyrase 1 binding protein 1	51	0.96
chr1_85526452_85526618	1.00	AC147806.2	predicted 7592	67	0.59
chr13_29292838_29292989	1.00	Gm11364	predicted gene 11364	56293	0.16
chr2_132169135_132169286	1.00	Slc23a2	solute carrier family 23 (nucleobase transporters), member 2	24102	0.14
chr17_5574750_5574911	0.99	Zdhhc14	zinc finger, DHHC domain containing 14	82273	0.08
chr16_97535057_97535341	0.99	Mx2	MX dynamin-like GTPase 2	109	0.96
chr17_31075917_31076069	0.98	Gm25447	predicted gene, 25447	16389	0.12
chr14_25686626_25686801	0.96	Ppif	peptidylprolyl isomerase F (cyclophilin F)	7441	0.14
chr5_100587706_100587862	0.96	Gm43510	predicted gene 43510	4972	0.16
chr5_21131284_21131470	0.96	Gm42660	predicted gene 42660	301	0.86
chr10_37145852_37146014	0.95	5930403N24Rik	RIKEN cDNA 5930403N24 gene	4844	0.21
chr5_102485247_102485411	0.95	1700013M08Rik	RIKEN cDNA 1700013M08 gene	2040	0.35
chr14_17410906_17411057	0.94	Thrb	thyroid hormone receptor beta	249280	0.02
chr1_177260954_177261105	0.94	Akt3	thymoma viral proto-oncogene 3	2826	0.24
chr1_85649860_85650030	0.93	Sp100	nuclear antigen Sp100	43	0.91
chr3_27267495_27267649	0.93	Gm37191	predicted gene, 37191	10488	0.19
chr7_83581375_83581526	0.92	Tmc3	transmembrane channel-like gene family 3	3477	0.19
chr5_136084893_136085068	0.91	Rasa4	RAS p21 protein activator 4	90	0.93
chr9_79154890_79155051	0.91	Gm47499	predicted gene, 47499	47037	0.14
chr3_142530130_142530290	0.90	Gbp7	guanylate binding protein 7	132	0.95
chr3_58719714_58719873	0.89	4930593A02Rik	RIKEN cDNA 4930593A02 gene	13037	0.14
chr9_65536208_65536383	0.89	Gm17749	predicted gene, 17749	6489	0.14
chr4_98923183_98923363	0.88	Usp1	ubiquitin specific peptidase 1	537	0.77
chr15_58016804_58016970	0.88	9130401M01Rik	RIKEN cDNA 9130401M01 gene	11008	0.14
chr17_26753562_26753741	0.87	Crebrf	CREB3 regulatory factor	4051	0.18
chr11_21046361_21046512	0.86	Peli1	pellino 1	44855	0.14
chr4_72122622_72122773	0.86	Tle1	transducin-like enhancer of split 1	1963	0.41
chr7_104315439_104315612	0.85	Trim12a	tripartite motif-containing 12A	59	0.86
chr2_15635875_15636043	0.85	Gm37595	predicted gene, 37595	104846	0.07
chr6_97464282_97464478	0.85	Frmd4b	FERM domain containing 4B	5094	0.23
chr15_58019663_58019825	0.84	9130401M01Rik	RIKEN cDNA 9130401M01 gene	8151	0.14
chr17_86470447_86470748	0.84	Prkce	protein kinase C, epsilon	19965	0.22
chr4_150784707_150784885	0.83	Gm13049	predicted gene 13049	40937	0.13
chr1_85327350_85327504	0.83	Gm2619	predicted gene 2619	142	0.87
chr2_132114570_132114788	0.82	Slc23a2	solute carrier family 23 (nucleobase transporters), member 2	3231	0.22
chr11_58199417_58199593	0.82	Igtp	interferon gamma induced GTPase	51	0.57
chr15_77411058_77411216	0.81	Apol9a	apolipoprotein L 9a	2	0.95
chr1_67092581_67092813	0.81	Cps1	carbamoyl-phosphate synthetase 1	30329	0.17
chr12_111071868_111072033	0.81	Gm46379	predicted gene, 46379	3922	0.17
chr6_120112510_120112682	0.81	Ninj2	ninjurin 2	19246	0.17
chr11_100704164_100704495	0.80	Dhx58	DEXH (Asp-Glu-X-His) box polypeptide 58	58	0.94
chr10_20005611_20005762	0.80	Map3k5	mitogen-activated protein kinase kinase kinase 5	54631	0.13
chr1_85199424_85199611	0.80	AC123856.1	nuclear antigen Sp100 (Sp100) pseudogene	96	0.49
chr11_60076243_60076400	0.79	Rai1	retinoic acid induced 1	28692	0.12
chr1_182670647_182670811	0.78	Gm37516	predicted gene, 37516	9210	0.19
chr17_36042825_36042981	0.77	Gm6034	predicted gene 6034	58	0.61
chr15_79063149_79063317	0.75	Ankrd54	ankyrin repeat domain 54	340	0.68
chr7_104288066_104288279	0.75	Trim5	tripartite motif-containing 5	78	0.93
chr5_21054265_21054635	0.75	Ptpn12	protein tyrosine phosphatase, non-receptor type 12	1275	0.41
chr3_142496733_142496931	0.74	Gbp5	guanylate binding protein 5	68	0.97
chr2_84799293_84799459	0.73	Ube2l6	ubiquitin-conjugating enzyme E2L 6	542	0.62
chr2_48333003_48333182	0.73	Gm13482	predicted gene 13482	34184	0.18
chr17_35263604_35263786	0.73	H2-D1	histocompatibility 2, D region locus 1	599	0.4
chr15_77728956_77729123	0.73	Apol9b	apolipoprotein L 9b	0	0.95
chr4_86886599_86886793	0.72	Acer2	alkaline ceramidase 2	12282	0.21
chr5_92093819_92093994	0.72	G3bp2	GTPase activating protein (SH3 domain) binding protein 2	10187	0.12
chr16_78540459_78540629	0.71	D16Ertd472e	DNA segment, Chr 16, ERATO Doi 472, expressed	19700	0.16
chr1_92906015_92906166	0.71	Dusp28	dual specificity phosphatase 28	891	0.37
chr11_58214796_58214953	0.71	Irgm2	immunity-related GTPase family M member 2	134	0.93
chr12_79841402_79841571	0.69	9430078K24Rik	RIKEN cDNA 9430078K24 gene	83247	0.09
chr1_61374326_61374510	0.69	9530026F06Rik	RIKEN cDNA 9530026F06 gene	4014	0.24
chr11_113101446_113101611	0.69	2610035D17Rik	RIKEN cDNA 2610035D17 gene	71549	0.12
chr2_131089744_131089895	0.69	Siglec1	sialic acid binding Ig-like lectin 1, sialoadhesin	3054	0.15
chr1_186478678_186478837	0.68	A730004F24Rik	RIKEN cDNA A730004F24 gene	79715	0.1
chr3_148998735_148998917	0.67	Gm43572	predicted gene 43572	6670	0.18
chr2_62645973_62646316	0.67	Ifih1	interferon induced with helicase C domain 1	9	0.98
chr2_167698008_167698170	0.67	A530013C23Rik	RIKEN cDNA A530013C23 gene	6908	0.12
chr9_99491119_99491307	0.67	Nme9	NME/NM23 family member 9	20792	0.16
chr1_150496695_150496846	0.66	Prg4	proteoglycan 4 (megakaryocyte stimulating factor, articular superficial zone protein)	30605	0.15
chr8_84974794_84975075	0.66	AC163703.1		1608	0.14
chr2_162976070_162976402	0.66	Gm11453	predicted gene 11453	7025	0.13
chr16_30959779_30959977	0.66	Gm15742	predicted gene 15742	13640	0.17
chr10_20674107_20674323	0.66	Gm17230	predicted gene 17230	48580	0.14
chr9_120721526_120721702	0.65	Gm47063	predicted gene, 47063	15377	0.13
chr8_107561268_107561433	0.65	Wwp2	WW domain containing E3 ubiquitin protein ligase 2	10013	0.17
chr1_161951168_161951368	0.65	4930558K02Rik	RIKEN cDNA 4930558K02 gene	17880	0.12
chr9_109054788_109055359	0.64	Shisa5	shisa family member 5	61	0.94
chr17_36020984_36021135	0.64	H2-T24	histocompatibility 2, T region locus 24	499	0.51
chr4_145640689_145640849	0.64	Gm13231	predicted gene 13231	588	0.58
chr17_36023597_36023890	0.63	H2-T24	histocompatibility 2, T region locus 24	3183	0.08
chr7_19563093_19563255	0.63	Ppp1r37	protein phosphatase 1, regulatory subunit 37	98	0.93
chr7_119527230_119527542	0.63	Acsm5	acyl-CoA synthetase medium-chain family member 5	1045	0.36
chr2_22623304_22623471	0.62	Gad2	glutamic acid decarboxylase 2	83	0.96
chr18_84906289_84906638	0.62	Fbxo15	F-box protein 15	28319	0.13
chr3_135423942_135424111	0.62	Cisd2	CDGSH iron sulfur domain 2	101	0.94
chr15_74989416_74989586	0.62	Gm37042	predicted gene, 37042	751	0.35
chr5_9059465_9059641	0.61	Gm40264	predicted gene, 40264	24429	0.13
chr15_76951965_76952120	0.61	1110038F14Rik	RIKEN cDNA 1110038F14 gene	3293	0.13
chr14_66872697_66872883	0.61	Gm5464	predicted gene 5464	3940	0.18
chr6_22010400_22010560	0.61	Cped1	cadherin-like and PC-esterase domain containing 1	6586	0.27
chr13_34738568_34738735	0.61	Fam50b	family with sequence similarity 50, member B	961	0.45
chr1_156009145_156009296	0.59	Tor1aip1	torsin A interacting protein 1	9399	0.14
chr9_107975178_107975582	0.59	Uba7	ubiquitin-like modifier activating enzyme 7	125	0.87
chr18_75378610_75378854	0.59	Smad7	SMAD family member 7	3818	0.25
chr16_95432244_95432403	0.58	Erg	ETS transcription factor	26922	0.22
chr2_156857523_156857697	0.58	4930518I15Rik	RIKEN cDNA 4930518I15 gene	336	0.71
chr8_8334587_8334760	0.57	A630009H07Rik	RIKEN cDNA A630009H07 gene	404	0.8
chr13_109604491_109604696	0.57	Pde4d	phosphodiesterase 4D, cAMP specific	23188	0.29
chr1_152677737_152678058	0.57	Gm15479	predicted gene 15479	9604	0.19
chr3_127123389_127123738	0.57	Ank2	ankyrin 2, brain	1299	0.38
chr10_81247872_81248124	0.56	Zfr2	zinc finger RNA binding protein 2	418	0.6
chr19_34553644_34553830	0.56	Ifit2	interferon-induced protein with tetratricopeptide repeats 2	3027	0.16
chr2_105396213_105396364	0.56	Rcn1	reticulocalbin 1	940	0.67
chr19_29940298_29940515	0.55	Il33	interleukin 33	5384	0.21
chr6_121196988_121197205	0.55	Gm44014	predicted gene, 44014	1087	0.4
chr8_111543847_111544013	0.55	Znrf1	zinc and ring finger 1	2671	0.26
chr11_48871336_48871517	0.55	Irgm1	immunity-related GTPase family M member 1	6	0.95
chr10_95297928_95298105	0.55	Gm48880	predicted gene, 48880	16837	0.14
chr2_122145860_122146082	0.55	B2m	beta-2 microglobulin	1715	0.25
chr16_10417919_10418097	0.55	Nubp1	nucleotide binding protein 1	3228	0.2
chr4_124646730_124646881	0.54	Pou3f1	POU domain, class 3, transcription factor 1	10002	0.12
chr2_91216142_91216316	0.54	Acp2	acid phosphatase 2, lysosomal	13301	0.09
chr17_36121547_36121705	0.54	Gm19684	predicted gene, 19684	52	0.61
chr19_47222639_47222810	0.54	Gm50339	predicted gene, 50339	815	0.48
chr18_68011811_68011962	0.54	Ldlrad4	low density lipoprotein receptor class A domain containing 4	78629	0.09
chr2_60855128_60855295	0.53	Rbms1	RNA binding motif, single stranded interacting protein 1	26227	0.23
chr17_71101556_71101726	0.53	Myom1	myomesin 1	15245	0.15
chr19_11540212_11540374	0.53	Ms4a4d	membrane-spanning 4-domains, subfamily A, member 4D	3492	0.12
chr15_76251814_76251971	0.53	Mir6953	microRNA 6953	3701	0.08
chr6_116107833_116108253	0.52	Tmcc1	transmembrane and coiled coil domains 1	184	0.72
chr18_32693876_32694200	0.52	Gm25826	predicted gene, 25826	71982	0.1
chr8_3211565_3211796	0.52	Insr	insulin receptor	18963	0.18
chr2_84761940_84762112	0.52	Serping1	serine (or cysteine) peptidase inhibitor, clade G, member 1	13102	0.08
chr17_27790101_27790294	0.52	Rps2-ps9	ribosomal protein S2, pseudogene 9	5773	0.14
chr9_78149872_78150023	0.51	Cilk1	ciliogenesis associated kinase 1	5376	0.13
chr12_99407029_99407580	0.51	Foxn3	forkhead box N3	5301	0.18
chr11_119393297_119393480	0.50	Rnf213	ring finger protein 213	288	0.86
chr1_183298173_183298484	0.50	Aida	axin interactor, dorsalization associated	758	0.46
chr7_123025255_123025406	0.49	Gm45846	predicted gene 45846	6044	0.14
chr5_102440458_102440632	0.49	Gm42932	predicted gene 42932	24342	0.19
chr6_95018081_95018258	0.49	4930511E03Rik	RIKEN cDNA 4930511E03 gene	74335	0.09
chr11_88528923_88529091	0.49	Msi2	musashi RNA-binding protein 2	61140	0.12
chr12_17701834_17702059	0.49	Hpcal1	hippocalcin-like 1	11090	0.22
chr11_95858752_95858950	0.48	4833417C18Rik	RIKEN cDNA 4833417C18 gene	14	0.82
chr4_136213750_136213912	0.48	Asap3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3	7466	0.15
chr5_105110364_105110535	0.48	Gbp9	guanylate-binding protein 9	172	0.95
chr13_23669732_23669907	0.47	Gm22452	predicted gene, 22452	6798	0.06
chr3_84637962_84638124	0.47	Tmem154	transmembrane protein 154	28149	0.16
chr15_94948227_94948378	0.47	Gm23129	predicted gene, 23129	38836	0.22
chr10_128270229_128270557	0.47	Stat2	signal transducer and activator of transcription 2	166	0.86
chr8_25777362_25777542	0.47	Bag4	BCL2-associated athanogene 4	130	0.92
chr19_8806965_8807121	0.46	Zbtb3	zinc finger and BTB domain containing 3	4488	0.05
chr6_87531647_87531807	0.46	Arhgap25	Rho GTPase activating protein 25	1508	0.29
chr5_105139632_105139812	0.46	Gbp4	guanylate binding protein 4	136	0.4
chr10_95623611_95623772	0.45	Gm33336	predicted gene, 33336	8548	0.13
chr7_17090307_17090480	0.45	Psg16	pregnancy specific glycoprotein 16	2459	0.18
chr9_70761117_70761279	0.45	Adam10	a disintegrin and metallopeptidase domain 10	14855	0.2
chr3_69264430_69264585	0.45	Arl14	ADP-ribosylation factor-like 14	42088	0.12
chr18_60211943_60212106	0.45	Gm4951	predicted gene 4951	56	0.97
chr13_23710505_23710674	0.45	Hfe	homeostatic iron regulator	125	0.85
chr10_91183536_91183698	0.45	Tmpo	thymopoietin	2302	0.26
chr8_33471202_33471366	0.45	Hmgb1-rs17	high mobility group box 1, related sequence 17	12912	0.21
chr4_9658072_9658230	0.44	Asph	aspartate-beta-hydroxylase	10935	0.2
chr17_86601302_86601488	0.44	Gm18832	predicted gene, 18832	84101	0.08
chr1_63192366_63192525	0.44	Gm27512	predicted gene, 27512	5586	0.09
chr4_99185506_99185668	0.44	Atg4c	autophagy related 4C, cysteine peptidase	8347	0.18
chr19_43495970_43496152	0.43	Cnnm1	cyclin M1	2545	0.19
chr15_82643084_82643235	0.43	AC118710.1	cytochrome P450, family 2, subfamily d, polypeptide 13, pseudogene	1113	0.22
chr8_72409462_72409669	0.43	Eps15l1	epidermal growth factor receptor pathway substrate 15-like 1	11873	0.1
chr11_19016500_19016765	0.43	Meis1	Meis homeobox 1	343	0.83
chr18_70622479_70622643	0.43	Mbd2	methyl-CpG binding domain protein 2	4788	0.23
chr7_24884378_24884550	0.43	Rps19	ribosomal protein S19	93	0.93
chr15_28001392_28001573	0.43	Trio	triple functional domain (PTPRF interacting)	6119	0.24
chr3_59228865_59229051	0.43	P2ry12	purinergic receptor P2Y, G-protein coupled 12	1377	0.34
chr13_107568726_107569034	0.43	Gm32004	predicted gene, 32004	3549	0.29
chr3_118507933_118508602	0.42	Gm37773	predicted gene, 37773	17884	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	2.0	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.3	0.8	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
0.2	0.7	GO:0006538	glutamate catabolic process(GO:0006538)
0.2	0.6	GO:0097460	ferrous iron import into cell(GO:0097460)
0.1	0.7	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.1	0.4	GO:0090365	regulation of mRNA modification(GO:0090365)
0.1	0.4	GO:0039530	MDA-5 signaling pathway(GO:0039530)
0.1	0.4	GO:0060266	negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.1	0.4	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
0.1	0.3	GO:0010847	regulation of chromatin assembly(GO:0010847)
0.1	0.3	GO:1904139	microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.1	0.3	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.1	0.3	GO:0001692	histamine metabolic process(GO:0001692)
0.1	2.3	GO:0035458	cellular response to interferon-beta(GO:0035458)
0.1	1.4	GO:0044406	adhesion of symbiont to host(GO:0044406)
0.1	0.4	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.1	0.4	GO:0090086	negative regulation of protein deubiquitination(GO:0090086)
0.1	0.7	GO:0035520	monoubiquitinated protein deubiquitination(GO:0035520)
0.1	0.2	GO:0002741	positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.1	0.2	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.1	0.2	GO:0090283	regulation of protein glycosylation in Golgi(GO:0090283)
0.1	0.3	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.1	0.2	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1	0.2	GO:0015888	thiamine transport(GO:0015888)
0.1	0.4	GO:2000051	negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
0.1	1.3	GO:0034340	response to type I interferon(GO:0034340)
0.1	0.2	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.1	0.2	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.1	0.1	GO:0002488	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489)
0.1	0.5	GO:0002485	antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway(GO:0002484) antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent(GO:0002485)
0.1	0.2	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.1	0.2	GO:0045006	DNA deamination(GO:0045006)
0.1	0.2	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.1	0.2	GO:0055059	asymmetric neuroblast division(GO:0055059)
0.1	0.2	GO:0002309	T cell proliferation involved in immune response(GO:0002309)
0.1	0.4	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.2	GO:1902093	positive regulation of sperm motility(GO:1902093)
0.0	0.3	GO:0090188	negative regulation of pancreatic juice secretion(GO:0090188)
0.0	0.2	GO:2000015	regulation of determination of dorsal identity(GO:2000015)
0.0	0.1	GO:2000275	regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.0	0.2	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.2	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.7	GO:0034587	piRNA metabolic process(GO:0034587)
0.0	0.1	GO:0002432	granuloma formation(GO:0002432)
0.0	0.3	GO:0032464	positive regulation of protein homooligomerization(GO:0032464)
0.0	1.0	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.3	GO:1904417	regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.0	0.1	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.4	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.1	GO:0042939	glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.0	0.2	GO:2000672	negative regulation of motor neuron apoptotic process(GO:2000672)
0.0	0.2	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.1	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
0.0	0.1	GO:0051025	negative regulation of immunoglobulin secretion(GO:0051025)
0.0	0.9	GO:0034260	negative regulation of GTPase activity(GO:0034260)
0.0	0.1	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.1	GO:0052055	modulation by symbiont of host molecular function(GO:0052055)
0.0	0.1	GO:0061366	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.2	GO:0035404	histone-serine phosphorylation(GO:0035404)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.2	GO:0071763	nuclear membrane organization(GO:0071763)
0.0	0.1	GO:0010528	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0	0.1	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.2	GO:0044539	long-chain fatty acid import(GO:0044539)
0.0	0.2	GO:0000820	regulation of glutamine family amino acid metabolic process(GO:0000820)
0.0	0.1	GO:0060830	ciliary receptor clustering involved in smoothened signaling pathway(GO:0060830)
0.0	0.1	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.1	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:0060282	positive regulation of oocyte development(GO:0060282)
0.0	0.3	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	0.1	GO:0021764	amygdala development(GO:0021764)
0.0	0.2	GO:0085020	protein K6-linked ubiquitination(GO:0085020)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:1904252	negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0	0.2	GO:0048102	autophagic cell death(GO:0048102)
0.0	0.1	GO:0072697	protein localization to cell cortex(GO:0072697)
0.0	0.0	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
0.0	0.1	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.1	GO:1901856	negative regulation of cellular respiration(GO:1901856)
0.0	0.3	GO:0009226	nucleotide-sugar biosynthetic process(GO:0009226)
0.0	0.1	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.1	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.0	GO:0002536	respiratory burst involved in inflammatory response(GO:0002536)
0.0	0.1	GO:0032907	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.0	0.1	GO:0097211	response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0	0.1	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.2	GO:1903405	protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.0	0.1	GO:0050747	positive regulation of lipoprotein metabolic process(GO:0050747)
0.0	0.1	GO:0034145	positive regulation of toll-like receptor 4 signaling pathway(GO:0034145)
0.0	0.1	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.2	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.0	0.1	GO:0033058	directional locomotion(GO:0033058)
0.0	0.2	GO:0032607	interferon-alpha production(GO:0032607)
0.0	0.2	GO:1902033	regulation of hematopoietic stem cell proliferation(GO:1902033)
0.0	0.0	GO:0043137	DNA replication, removal of RNA primer(GO:0043137)
0.0	0.1	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.0	0.0	GO:0030885	regulation of myeloid dendritic cell activation(GO:0030885)
0.0	0.6	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.0	0.1	GO:0006203	dGTP catabolic process(GO:0006203)
0.0	0.1	GO:0051697	protein delipidation(GO:0051697)
0.0	0.6	GO:0042771	intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0	0.1	GO:0061635	regulation of protein complex stability(GO:0061635)
0.0	0.3	GO:0035335	peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0	0.1	GO:0030167	proteoglycan catabolic process(GO:0030167)
0.0	0.1	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.2	GO:2001224	positive regulation of neuron migration(GO:2001224)
0.0	0.1	GO:0045629	negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.0	0.3	GO:0040015	negative regulation of multicellular organism growth(GO:0040015)
0.0	0.0	GO:1900044	regulation of protein K63-linked ubiquitination(GO:1900044)
0.0	0.1	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.0	GO:0097527	necroptotic signaling pathway(GO:0097527)
0.0	0.1	GO:0001927	exocyst assembly(GO:0001927)
0.0	0.1	GO:0019478	D-amino acid catabolic process(GO:0019478)
0.0	0.1	GO:0031584	activation of phospholipase D activity(GO:0031584)
0.0	0.0	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0	0.0	GO:0045357	interferon-beta biosynthetic process(GO:0045350) regulation of interferon-beta biosynthetic process(GO:0045357)
0.0	0.2	GO:0090161	Golgi ribbon formation(GO:0090161)
0.0	0.0	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0051891	positive regulation of cardioblast differentiation(GO:0051891)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.1	GO:0010452	histone H3-K36 methylation(GO:0010452)
0.0	0.0	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.0	GO:0030578	PML body organization(GO:0030578)
0.0	0.0	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0	0.4	GO:0010259	multicellular organism aging(GO:0010259)
0.0	0.0	GO:0001794	type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) positive regulation of type IIa hypersensitivity(GO:0001798) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892) positive regulation of type II hypersensitivity(GO:0002894)
0.0	0.1	GO:0051770	positive regulation of nitric-oxide synthase biosynthetic process(GO:0051770)
0.0	0.3	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.0	GO:1903242	regulation of cardiac muscle adaptation(GO:0010612) regulation of cardiac muscle hypertrophy in response to stress(GO:1903242)
0.0	0.0	GO:0038171	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.4	GO:0000002	mitochondrial genome maintenance(GO:0000002)
0.0	0.1	GO:2000258	negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.0	0.0	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.1	GO:0070234	positive regulation of T cell apoptotic process(GO:0070234)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.0	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0080154	regulation of fertilization(GO:0080154)
0.0	0.0	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
0.0	0.1	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.0	0.1	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
0.0	0.0	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.1	GO:0006977	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.0	0.0	GO:0030070	insulin processing(GO:0030070)
0.0	0.1	GO:0010991	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0	0.0	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.1	GO:2000042	negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.0	0.0	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.1	GO:0045654	positive regulation of megakaryocyte differentiation(GO:0045654)
0.0	0.0	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.0	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.1	GO:0042985	negative regulation of amyloid precursor protein biosynthetic process(GO:0042985)
0.0	0.0	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.1	GO:0060789	hair follicle placode formation(GO:0060789)
0.0	0.1	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0	0.0	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.3	GO:0015701	bicarbonate transport(GO:0015701)
0.0	0.0	GO:0034093	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.2	GO:0006474	N-terminal protein amino acid acetylation(GO:0006474)
0.0	0.6	GO:0032543	mitochondrial translation(GO:0032543)
0.0	0.0	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.0	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.0	GO:0002322	B cell proliferation involved in immune response(GO:0002322)
0.0	0.0	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.0	0.1	GO:0014049	positive regulation of glutamate secretion(GO:0014049)
0.0	0.1	GO:0000042	protein targeting to Golgi(GO:0000042)
0.0	0.0	GO:2001171	positive regulation of ATP biosynthetic process(GO:2001171)
0.0	0.2	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0	0.2	GO:0099514	anterograde synaptic vesicle transport(GO:0048490) synaptic vesicle cytoskeletal transport(GO:0099514) synaptic vesicle transport along microtubule(GO:0099517)
0.0	0.0	GO:0061153	trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0	0.2	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.0	GO:0099558	maintenance of synapse structure(GO:0099558)
0.0	0.0	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.1	GO:1903147	negative regulation of mitophagy(GO:1903147)
0.0	0.3	GO:0010762	regulation of fibroblast migration(GO:0010762)
0.0	0.0	GO:1901299	negative regulation of hydrogen peroxide-mediated programmed cell death(GO:1901299)
0.0	0.4	GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0	0.1	GO:0006744	ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0000395	mRNA 5'-splice site recognition(GO:0000395)
0.0	0.1	GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.1	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.0	0.0	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.0	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.0	GO:2001046	positive regulation of integrin-mediated signaling pathway(GO:2001046)
0.0	0.0	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.5	GO:0019882	antigen processing and presentation(GO:0019882)
0.0	0.0	GO:0019230	proprioception(GO:0019230)
0.0	0.0	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.8	GO:1990462	omegasome(GO:1990462)
0.3	2.4	GO:0020003	symbiont-containing vacuole(GO:0020003)
0.1	0.7	GO:0071547	piP-body(GO:0071547)
0.1	0.6	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.1	0.9	GO:0031235	intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1	0.3	GO:1990111	spermatoproteasome complex(GO:1990111)
0.1	1.0	GO:0030014	CCR4-NOT complex(GO:0030014)
0.1	0.2	GO:0042585	germinal vesicle(GO:0042585)
0.1	0.2	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	0.3	GO:0005767	secondary lysosome(GO:0005767)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0042825	TAP complex(GO:0042825)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.2	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.2	GO:0005638	lamin filament(GO:0005638)
0.0	0.6	GO:0060077	inhibitory synapse(GO:0060077)
0.0	0.3	GO:0031932	TORC2 complex(GO:0031932)
0.0	0.4	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.3	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.6	GO:0000314	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.3	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0071458	integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:0034457	Mpp10 complex(GO:0034457)
0.0	0.1	GO:0032133	chromosome passenger complex(GO:0032133)
0.0	0.1	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.2	GO:0005832	chaperonin-containing T-complex(GO:0005832)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.3	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.6	GO:0009925	basal plasma membrane(GO:0009925)
0.0	0.1	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.2	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.7	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
0.0	0.1	GO:0030478	actin cap(GO:0030478)
0.0	0.2	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.0	0.1	GO:0043083	synaptic cleft(GO:0043083)
0.0	0.5	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
0.0	0.0	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.0	GO:0071797	LUBAC complex(GO:0071797)
0.0	0.0	GO:0042719	mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.0	0.1	GO:0005964	phosphorylase kinase complex(GO:0005964)
0.0	0.3	GO:0022624	proteasome accessory complex(GO:0022624)
0.0	0.2	GO:0032839	dendrite cytoplasm(GO:0032839)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.1	GO:0032593	insulin-responsive compartment(GO:0032593)
0.0	0.0	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0061700	GATOR2 complex(GO:0061700)
0.0	0.1	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.0	GO:0000322	storage vacuole(GO:0000322)
0.0	0.0	GO:0032127	dense core granule membrane(GO:0032127)
0.0	0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.0	0.4	GO:0030173	integral component of Golgi membrane(GO:0030173)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.6	GO:0004351	glutamate decarboxylase activity(GO:0004351)
0.2	0.7	GO:0034584	piRNA binding(GO:0034584)
0.2	0.5	GO:0042296	ISG15 transferase activity(GO:0042296)
0.2	0.6	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.1	0.4	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1	1.8	GO:0008329	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.1	1.0	GO:0031386	protein tag(GO:0031386)
0.1	0.5	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.1	0.3	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.1	0.2	GO:0015440	peptide-transporting ATPase activity(GO:0015440) MHC class Ib protein binding(GO:0023029)
0.1	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.1	0.3	GO:0017040	ceramidase activity(GO:0017040)
0.1	0.4	GO:1990459	transferrin receptor binding(GO:1990459)
0.1	0.2	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)
0.1	0.4	GO:0034046	poly(G) binding(GO:0034046)
0.1	0.3	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.2	GO:0071987	WD40-repeat domain binding(GO:0071987)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.2	GO:0044682	N-cyclopropylmelamine deaminase activity(GO:0034547) N-cyclopropylammeline deaminase activity(GO:0034548) N-cyclopropylammelide alkylamino hydrolase activity(GO:0034549) 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity(GO:0043723) tRNA-specific adenosine-37 deaminase activity(GO:0043829) archaeal-specific GTP cyclohydrolase activity(GO:0044682) tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.0	0.7	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0034040	lipid-transporting ATPase activity(GO:0034040)
0.0	0.2	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	1.1	GO:0042605	peptide antigen binding(GO:0042605)
0.0	0.1	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.1	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.1	GO:0016018	cyclosporin A binding(GO:0016018)
0.0	0.1	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.4	GO:0070567	cytidylyltransferase activity(GO:0070567)
0.0	0.3	GO:0001671	ATPase activator activity(GO:0001671)
0.0	0.2	GO:0061133	endopeptidase activator activity(GO:0061133)
0.0	0.4	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0033677	DNA/RNA helicase activity(GO:0033677)
0.0	0.2	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.2	GO:0008093	cytoskeletal adaptor activity(GO:0008093)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0080130	L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.0	0.1	GO:0004305	ethanolamine kinase activity(GO:0004305)
0.0	0.5	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.7	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	4.8	GO:0003924	GTPase activity(GO:0003924)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0070840	dynein complex binding(GO:0070840)
0.0	0.3	GO:0036312	phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.0	0.1	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.0	0.1	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0	0.2	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	0.2	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0	0.6	GO:0004864	protein phosphatase inhibitor activity(GO:0004864)
0.0	0.1	GO:0001135	transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0008545	JUN kinase kinase activity(GO:0008545)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)
0.0	1.2	GO:0003725	double-stranded RNA binding(GO:0003725)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.1	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.5	GO:0050699	WW domain binding(GO:0050699)
0.0	0.2	GO:0015174	basic amino acid transmembrane transporter activity(GO:0015174)
0.0	0.1	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.4	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.4	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.4	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0	0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.2	GO:0017081	chloride channel regulator activity(GO:0017081)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.0	GO:0051733	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.1	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.7	GO:0019843	rRNA binding(GO:0019843)
0.0	0.1	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554)
0.0	0.3	GO:0015301	anion:anion antiporter activity(GO:0015301)
0.0	0.0	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.1	GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.0	0.1	GO:0004689	phosphorylase kinase activity(GO:0004689)
0.0	0.0	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.0	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0030332	cyclin binding(GO:0030332)
0.0	0.1	GO:0036122	BMP binding(GO:0036122)
0.0	0.0	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.0	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.1	GO:0017108	5'-flap endonuclease activity(GO:0017108)
0.0	0.0	GO:0017116	single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.0	0.5	GO:0005080	protein kinase C binding(GO:0005080)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.3	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
1.1	PID RAS PATHWAY	Regulation of Ras family activation
0.3	PID BARD1 PATHWAY	BARD1 signaling events
0.1	PID TRAIL PATHWAY	TRAIL signaling pathway
0.2	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.9	PID FANCONI PATHWAY	Fanconi anemia pathway
0.6	ST GA13 PATHWAY	G alpha 13 Pathway
0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.5	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.6	PID TELOMERASE PATHWAY	Regulation of Telomerase
0.1	PID IL5 PATHWAY	IL5-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY	Genes involved in Regulation of the Fanconi anemia pathway
0.1	2.9	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1	0.2	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.1	1.0	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	1.7	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
0.1	2.2	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.1	0.5	REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS	Genes involved in RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
0.0	0.1	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.2	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.3	REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS	Genes involved in Bile salt and organic anion SLC transporters
0.0	0.3	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0	0.4	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
0.0	0.4	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.2	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.2	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.0	0.2	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.0	REACTOME SIGNALING BY ERBB2	Genes involved in Signaling by ERBB2
0.0	0.3	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.2	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.0	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.0	REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0	0.3	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.1	REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION	Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0	0.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.0	0.1	REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE	Genes involved in p53-Dependent G1 DNA Damage Response
0.0	0.1	REACTOME HORMONE LIGAND BINDING RECEPTORS	Genes involved in Hormone ligand-binding receptors
0.0	0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.4	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex

Results for Irf3

Z-value: 2.60

Motif logo

Transcription factors associated with Irf3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Irf3 motif across conditions

Conditions sorted by the z-value of the Irf3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: