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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Irf4

Z-value: 2.55

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Transcription factors associated with Irf4

Gene Symbol	Gene ID	Gene Info
Irf4 Ensembl NCBI MGI UniProt	ENSMUSG00000021356.3	interferon regulatory factor 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr13_30767832_30768011	Irf4	18614	0.174077	0.72	1.1e-01	Click!
chr13_30749140_30749314	Irf4	1	0.978975	-0.20	7.0e-01	Click!

Activity of the Irf4 motif across conditions

Conditions sorted by the z-value of the Irf4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_5601306_5601460	1.42	Gm13216	predicted gene 13216	2188	0.41
chr5_130301045_130301196	1.00	Tyw1	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	42190	0.1
chr12_112667742_112667901	0.79	Akt1	thymoma viral proto-oncogene 1	293	0.81
chr15_36879731_36879883	0.78	Gm10384	predicted gene 10384	9	0.97
chr5_30551378_30551537	0.77	Cib4	calcium and integrin binding family member 4	5621	0.14
chr8_88668645_88668844	0.75	Nod2	nucleotide-binding oligomerization domain containing 2	17403	0.15
chr9_122634913_122635137	0.73	Gm47134	predicted gene, 47134	12805	0.13
chr7_140774136_140774490	0.73	Cyp2e1	cytochrome P450, family 2, subfamily e, polypeptide 1	9832	0.08
chr12_35681929_35682122	0.69	9130015A21Rik	RIKEN cDNA 9130015A21 gene	4279	0.24
chr12_57027621_57027780	0.65	Slc25a21	solute carrier family 25 (mitochondrial oxodicarboxylate carrier), member 21	47307	0.18
chr16_81366011_81366177	0.65	Gm49555	predicted gene, 49555	75932	0.11
chr11_121796139_121796290	0.63	Gm12589	predicted gene 12589	6893	0.15
chr7_35748679_35748830	0.62	Dpy19l3	dpy-19-like 3 (C. elegans)	5601	0.2
chr17_12245181_12245338	0.61	Map3k4	mitogen-activated protein kinase kinase kinase 4	15043	0.14
chr13_23299091_23299367	0.59	Gm11333	predicted gene 11333	1180	0.26
chr8_106648617_106648783	0.58	Tango6	transport and golgi organization 6	34368	0.14
chr14_16546783_16546934	0.56	Rarb	retinoic acid receptor, beta	28187	0.19
chr11_121082992_121083151	0.56	Sectm1a	secreted and transmembrane 1A	1851	0.17
chr6_71193278_71193676	0.56	Fabp1	fatty acid binding protein 1, liver	6350	0.13
chr3_51475782_51475984	0.56	Naa15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	6737	0.1
chr11_98770698_98771034	0.55	Nr1d1	nuclear receptor subfamily 1, group D, member 1	440	0.69
chr15_97059709_97059903	0.55	Slc38a4	solute carrier family 38, member 4	3850	0.33
chr19_17313008_17313208	0.54	Gcnt1	glucosaminyl (N-acetyl) transferase 1, core 2	22328	0.18
chr14_117750473_117750636	0.53	Mir6239	microRNA 6239	203293	0.03
chr10_38136267_38136418	0.53	Gm31378	predicted gene, 31378	14281	0.19
chr1_156009145_156009296	0.52	Tor1aip1	torsin A interacting protein 1	9399	0.14
chr5_7277206_7277357	0.52	Gm43841	predicted gene 43841	957	0.52
chr2_35496007_35496180	0.52	Gm13445	predicted gene 13445	4574	0.15
chr2_68873804_68874167	0.51	Cers6	ceramide synthase 6	12399	0.14
chr4_135649660_135649811	0.51	1700029M20Rik	RIKEN cDNA 1700029M20 gene	22482	0.13
chr2_22994929_22995080	0.51	Gm13357	predicted gene 13357	24663	0.14
chr3_101496436_101496587	0.50	Gm42538	predicted gene 42538	69575	0.08
chr4_84540692_84540849	0.49	Bnc2	basonuclin 2	5520	0.32
chr3_135146834_135146985	0.49	Gm24048	predicted gene, 24048	499	0.77
chr13_31177508_31177666	0.48	Gm11372	predicted gene 11372	21499	0.2
chr1_72806058_72806277	0.48	Igfbp2	insulin-like growth factor binding protein 2	18336	0.2
chr3_18146779_18146930	0.48	Gm23686	predicted gene, 23686	30771	0.18
chr7_28322083_28322289	0.48	Supt5	suppressor of Ty 5, DSIF elongation factor subunit	3394	0.1
chr4_107285558_107285727	0.47	Gm12850	predicted gene 12850	15208	0.11
chr11_118265609_118265912	0.47	Usp36	ubiquitin specific peptidase 36	288	0.89
chr2_91750560_91750711	0.47	Ambra1	autophagy/beclin 1 regulator 1	15810	0.14
chr17_3794450_3794609	0.47	Nox3	NADPH oxidase 3	98268	0.08
chr12_81905904_81906074	0.46	Pcnx	pecanex homolog	12654	0.23
chr13_64101697_64101975	0.46	Slc35d2	solute carrier family 35, member D2	5327	0.16
chr6_145469244_145469410	0.46	Gm25373	predicted gene, 25373	5138	0.18
chr19_32992433_32992599	0.45	Gm36860	predicted gene, 36860	12453	0.25
chr7_132701485_132701636	0.44	Gm15582	predicted gene 15582	41676	0.13
chr6_86699596_86699790	0.44	Gm44214	predicted gene, 44214	11265	0.1
chr13_35817777_35817928	0.44	Gm48706	predicted gene, 48706	19102	0.16
chr3_96442671_96442858	0.44	Gm26232	predicted gene, 26232	7682	0.06
chr2_144441501_144441698	0.44	Zfp133-ps	zinc finger protein 133, pseudogene	17681	0.14
chr11_120817967_120818292	0.43	Fasn	fatty acid synthase	2674	0.13
chr6_9889970_9890125	0.43	Gm5110	predicted gene 5110	282807	0.01
chr4_101741736_101741946	0.43	Lepr	leptin receptor	24434	0.19
chr2_27555538_27555710	0.43	Gm13421	predicted gene 13421	15195	0.15
chr17_12722774_12722984	0.43	Airn	antisense Igf2r RNA	18432	0.13
chr5_22345406_22345583	0.43	Reln	reelin	792	0.56
chr5_105112436_105112587	0.42	Gbp9	guanylate-binding protein 9	2234	0.28
chr1_67006598_67006749	0.42	Lancl1	LanC (bacterial lantibiotic synthetase component C)-like 1	14392	0.17
chr3_133739026_133739177	0.42	Gm6135	prediticted gene 6135	52403	0.13
chr5_105067317_105067500	0.42	Gbp8	guanylate-binding protein 8	13852	0.16
chr1_76641343_76641507	0.42	Mir6343	microRNA 6343	131865	0.05
chr14_35842381_35842532	0.42	Gm49039	predicted gene, 49039	21847	0.21
chr11_16916263_16916490	0.42	Egfr	epidermal growth factor receptor	11191	0.18
chr16_87690191_87690394	0.42	Bach1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	8653	0.22
chr16_21646037_21646193	0.42	Vps8	VPS8 CORVET complex subunit	18484	0.2
chr9_74893793_74894014	0.41	Onecut1	one cut domain, family member 1	27419	0.13
chr11_101115731_101115904	0.41	Retreg3	reticulophagy regulator family member 3	3948	0.09
chr11_116848138_116848352	0.41	Mettl23	methyltransferase like 23	656	0.54
chr9_74885383_74885534	0.41	Onecut1	one cut domain, family member 1	18974	0.14
chr4_129126149_129126469	0.40	Hpca	hippocalcin	4273	0.13
chr2_181616903_181617061	0.40	Prpf6	pre-mRNA splicing factor 6	15609	0.08
chr1_92906015_92906166	0.40	Dusp28	dual specificity phosphatase 28	891	0.37
chr2_58562897_58563104	0.40	Acvr1	activin A receptor, type 1	3826	0.25
chr6_29812266_29812421	0.40	Ahcyl2	S-adenosylhomocysteine hydrolase-like 2	10484	0.19
chr7_88307523_88307674	0.40	Gm44751	predicted gene 44751	3880	0.23
chr11_98772948_98773272	0.39	Nr1d1	nuclear receptor subfamily 1, group D, member 1	2223	0.16
chr4_133680298_133680626	0.39	Pigv	phosphatidylinositol glycan anchor biosynthesis, class V	7815	0.13
chr18_33434286_33434492	0.38	Nrep	neuronal regeneration related protein	29046	0.17
chr5_125483749_125483900	0.38	Gm27551	predicted gene, 27551	4447	0.15
chr9_121799898_121800060	0.38	Hhatl	hedgehog acyltransferase-like	7472	0.08
chr9_102516246_102516552	0.38	Ky	kyphoscoliosis peptidase	4937	0.14
chr6_5165732_5165895	0.38	Pon1	paraoxonase 1	27950	0.16
chr7_49358786_49358938	0.38	Nav2	neuron navigator 2	5859	0.24
chr18_56722647_56722845	0.37	Lmnb1	lamin B1	5695	0.21
chr2_8124301_8124468	0.37	Gm13254	predicted gene 13254	23481	0.29
chr11_16796724_16796875	0.37	Egfros	epidermal growth factor receptor, opposite strand	33903	0.15
chr7_67772293_67772458	0.37	Gm23844	predicted gene, 23844	6155	0.12
chr2_150831134_150831285	0.37	Pygb	brain glycogen phosphorylase	2821	0.2
chr12_29971823_29971989	0.37	Pxdn	peroxidasin	24532	0.22
chr2_31733558_31733887	0.37	Abl1	c-abl oncogene 1, non-receptor tyrosine kinase	26221	0.12
chr18_12635348_12635516	0.37	Ttc39c	tetratricopeptide repeat domain 39C	7912	0.15
chr1_57850017_57850193	0.37	Spats2l	spermatogenesis associated, serine-rich 2-like	4534	0.28
chr8_77410509_77410680	0.37	Gm45407	predicted gene 45407	38078	0.15
chr9_74887027_74887191	0.37	Onecut1	one cut domain, family member 1	20625	0.14
chr2_167805079_167805230	0.36	9230111E07Rik	RIKEN cDNA 9230111E07 gene	23101	0.13
chr9_21609955_21610121	0.36	Gm7904	predicted gene 7904	1711	0.2
chr5_43973666_43973822	0.36	Fgfbp1	fibroblast growth factor binding protein 1	7309	0.11
chr1_13487930_13488274	0.36	Gm7593	predicted gene 7593	80447	0.07
chr18_5091846_5091997	0.35	Svil	supervillin	2460	0.4
chr10_95429680_95429831	0.35	5730420D15Rik	RIKEN cDNA 5730420D15 gene	12380	0.12
chr2_153427016_153427191	0.35	Gm14472	predicted gene 14472	13254	0.15
chr11_51632453_51632652	0.35	Rmnd5b	required for meiotic nuclear division 5 homolog B	3095	0.15
chr1_174931281_174931454	0.34	Grem2	gremlin 2, DAN family BMP antagonist	9548	0.3
chr3_135306683_135306880	0.34	Slc9b2	solute carrier family 9, subfamily B (NHA2, cation proton antiporter 2), member 2	919	0.52
chr8_36920289_36920440	0.34	Dlc1	deleted in liver cancer 1	31993	0.18
chr6_144707085_144707314	0.34	Sox5os4	SRY (sex determining region Y)-box 5, opposite strand 4	13712	0.16
chr17_87379036_87379189	0.34	Ttc7	tetratricopeptide repeat domain 7	259	0.89
chr8_26697737_26697895	0.34	Gm32098	predicted gene, 32098	29510	0.14
chr1_132365008_132365179	0.34	Tmcc2	transmembrane and coiled-coil domains 2	145	0.93
chr13_92636201_92636364	0.34	Serinc5	serine incorporator 5	25108	0.19
chr8_114117394_114117594	0.34	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	16063	0.27
chr8_72665230_72665413	0.34	Nwd1	NACHT and WD repeat domain containing 1	8235	0.15
chr7_68047295_68047457	0.34	Igf1r	insulin-like growth factor I receptor	94549	0.07
chr7_80647525_80647688	0.34	Gm15880	predicted gene 15880	11589	0.16
chr5_90469109_90469447	0.34	Alb	albumin	6578	0.16
chr5_33337165_33337512	0.34	Maea	macrophage erythroblast attacher	1153	0.44
chr3_18125794_18126108	0.34	Gm23686	predicted gene, 23686	51674	0.12
chr8_67948591_67948742	0.34	Psd3	pleckstrin and Sec7 domain containing 3	3213	0.28
chr13_23307496_23307808	0.34	4930557F10Rik	RIKEN cDNA 4930557F10 gene	5748	0.09
chr10_7775521_7775695	0.34	B430219N15Rik	RIKEN cDNA B430219N15 gene	4577	0.12
chr13_16575272_16575646	0.34	Gm48497	predicted gene, 48497	41638	0.17
chr5_21131284_21131470	0.34	Gm42660	predicted gene 42660	301	0.86
chr3_152091714_152091865	0.34	Gipc2	GIPC PDZ domain containing family, member 2	11065	0.14
chr4_129067684_129067835	0.33	Rnf19b	ring finger protein 19B	8945	0.13
chr5_134544632_134544783	0.33	Gm42884	predicted gene 42884	7350	0.1
chr8_123661654_123661826	0.33	Rhou	ras homolog family member U	7811	0.05
chr4_101155628_101155779	0.33	Jak1	Janus kinase 1	584	0.72
chr1_58307346_58307497	0.33	Gm15759	predicted gene 15759	8235	0.17
chr11_75636681_75636832	0.33	Inpp5k	inositol polyphosphate 5-phosphatase K	2381	0.18
chr14_52120278_52120439	0.33	Rpgrip1	retinitis pigmentosa GTPase regulator interacting protein 1	751	0.49
chr13_107899701_107899915	0.33	Zswim6	zinc finger SWIM-type containing 6	9744	0.25
chr9_74304589_74304740	0.33	Wdr72	WD repeat domain 72	30530	0.19
chr10_118947836_118948008	0.33	Gm38403	predicted gene, 38403	20779	0.15
chr5_107146315_107146474	0.33	Gm43422	predicted gene 43422	10706	0.15
chr14_11691855_11692070	0.33	Gm48602	predicted gene, 48602	75981	0.1
chr13_40888163_40888333	0.33	Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	1055	0.36
chr18_5161426_5161612	0.32	Gm26682	predicted gene, 26682	4212	0.3
chr13_3526432_3526596	0.32	Gdi2	guanosine diphosphate (GDP) dissociation inhibitor 2	11549	0.15
chr12_117087223_117087392	0.32	Gm10421	predicted gene 10421	63908	0.14
chr2_59240099_59240256	0.32	Pkp4	plakophilin 4	10428	0.25
chr6_85919471_85919834	0.32	Gm18290	predicted gene, 18290	1766	0.16
chr6_115331060_115331211	0.32	Pparg	peroxisome proliferator activated receptor gamma	29816	0.17
chr15_88821550_88821729	0.32	Creld2	cysteine-rich with EGF-like domains 2	1993	0.22
chr7_80387821_80388050	0.32	Fes	feline sarcoma oncogene	1	0.96
chr16_18776692_18776858	0.32	Cldn5	claudin 5	72	0.96
chr5_63839759_63839942	0.32	0610040J01Rik	RIKEN cDNA 0610040J01 gene	27330	0.17
chr13_42528321_42528472	0.32	Gm47125	predicted gene, 47125	41067	0.17
chr2_166153080_166153383	0.32	Sulf2	sulfatase 2	1192	0.46
chr5_88508653_88508804	0.32	Jchain	immunoglobulin joining chain	17912	0.12
chr3_18157815_18158052	0.32	Gm23686	predicted gene, 23686	19692	0.22
chr6_66996591_66996844	0.32	Gm36816	predicted gene, 36816	11696	0.12
chr15_89126785_89126936	0.31	Hdac10	histone deacetylase 10	630	0.5
chr10_122569907_122570079	0.31	A130077B15Rik	RIKEN cDNA A130077B15 gene	102	0.97
chr13_56692137_56692672	0.31	Smad5	SMAD family member 5	10606	0.22
chr10_43996394_43996545	0.31	Gm10812	predicted gene 10812	7685	0.18
chr1_164446668_164446865	0.31	Atp1b1	ATPase, Na+/K+ transporting, beta 1 polypeptide	3047	0.2
chr9_21136037_21136188	0.31	Tyk2	tyrosine kinase 2	4869	0.1
chrX_167180336_167180487	0.31	Gm15228	predicted gene 15228	16314	0.18
chr9_43261927_43262320	0.31	D630033O11Rik	RIKEN cDNA D630033O11 gene	2010	0.28
chr1_157015300_157015451	0.31	Gm10531	predicted gene 10531	28172	0.15
chr11_83983433_83983594	0.31	Synrg	synergin, gamma	1217	0.48
chr10_18469789_18469963	0.31	Nhsl1	NHS-like 1	12	0.98
chr7_132811940_132812135	0.31	Fam53b	family with sequence similarity 53, member B	1058	0.48
chr4_88515717_88515868	0.31	Ifnb1	interferon beta 1, fibroblast	6982	0.13
chr16_45375950_45376110	0.31	Cd200	CD200 antigen	24282	0.16
chr18_41861273_41861424	0.31	Gm50410	predicted gene, 50410	13486	0.22
chr6_134452780_134452955	0.31	Lrp6	low density lipoprotein receptor-related protein 6	12141	0.17
chr1_164543147_164543444	0.31	D630023O14Rik	RIKEN cDNA D630023O14 gene	32160	0.13
chr17_80017716_80017955	0.31	Gm22215	predicted gene, 22215	15679	0.14
chr7_38189586_38189737	0.30	1600014C10Rik	RIKEN cDNA 1600014C10 gene	3390	0.17
chr5_125404132_125404424	0.30	Dhx37	DEAH (Asp-Glu-Ala-His) box polypeptide 37	11619	0.11
chr9_119407884_119408057	0.30	Gm47320	predicted gene, 47320	1046	0.39
chr10_24271362_24271524	0.30	Moxd1	monooxygenase, DBH-like 1	47898	0.13
chr3_79190459_79190611	0.30	Gm24150	predicted gene, 24150	5839	0.2
chr9_66832506_66832657	0.30	Aph1c	aph1 homolog C, gamma secretase subunit	2067	0.2
chr13_43346952_43347103	0.30	Sirt5	sirtuin 5	18469	0.16
chr16_33347206_33347363	0.30	1700007L15Rik	RIKEN cDNA 1700007L15 gene	33391	0.16
chr9_118674269_118674608	0.30	Itga9	integrin alpha 9	11397	0.23
chr4_59009253_59009437	0.30	Gm20503	predicted gene 20503	6135	0.14
chr16_55754536_55754701	0.30	Gm19771	predicted gene, 19771	14700	0.19
chr10_108416495_108416681	0.30	Gm36283	predicted gene, 36283	663	0.71
chr13_101216058_101216241	0.30	5930438M14Rik	RIKEN cDNA 5930438M14 gene	15978	0.22
chr9_84910698_84910870	0.29	Gm48821	predicted gene, 48821	13849	0.17
chr9_116175249_116175770	0.29	Tgfbr2	transforming growth factor, beta receptor II	149	0.95
chr19_36927869_36928317	0.29	Btaf1	B-TFIID TATA-box binding protein associated factor 1	2014	0.33
chr2_50813860_50814047	0.29	Gm13498	predicted gene 13498	95731	0.08
chr2_71327268_71327425	0.29	Slc25a12	solute carrier family 25 (mitochondrial carrier, Aralar), member 12	1494	0.38
chr16_90213476_90213653	0.29	Sod1	superoxide dismutase 1, soluble	7190	0.16
chr4_139252070_139252425	0.29	Capzb	capping protein (actin filament) muscle Z-line, beta	18864	0.13
chr18_65230189_65230498	0.29	Gm29966	predicted gene, 29966	13944	0.15
chr10_8783504_8783679	0.29	Sash1	SAM and SH3 domain containing 1	21117	0.18
chr5_113884823_113884991	0.29	Coro1c	coronin, actin binding protein 1C	1962	0.21
chr2_75706502_75706663	0.29	E030042O20Rik	RIKEN cDNA E030042O20 gene	1812	0.22
chr11_107393842_107393993	0.29	Gm11712	predicted gene 11712	6934	0.14
chr7_66135774_66135934	0.29	Gm18988	predicted gene, 18988	8155	0.13
chr7_4765364_4765545	0.29	Fam71e2	family with sequence similarity 71, member E2	5848	0.07
chr2_11332161_11332322	0.29	Gm37851	predicted gene, 37851	584	0.61
chr16_76237397_76237728	0.29	Nrip1	nuclear receptor interacting protein 1	86096	0.08
chr1_39650381_39650532	0.29	D930019O06Rik	RIKEN cDNA D930019O06	280	0.82

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.2	0.9	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.1	0.4	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.1	0.3	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.1	0.4	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.1	0.3	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1	0.3	GO:0060300	regulation of cytokine activity(GO:0060300)
0.1	0.3	GO:1901552	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.1	0.5	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.1	0.3	GO:0036015	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.1	0.3	GO:1900451	positive regulation of glutamate receptor signaling pathway(GO:1900451) positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity(GO:2000969)
0.1	0.3	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.1	0.2	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.1	0.2	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1	0.2	GO:0045726	positive regulation of integrin biosynthetic process(GO:0045726)
0.1	0.2	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.1	0.2	GO:2001206	positive regulation of osteoclast development(GO:2001206)
0.1	0.1	GO:1903416	response to glycoside(GO:1903416)
0.1	0.2	GO:1902083	negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.1	0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.1	GO:1990314	cellular response to insulin-like growth factor stimulus(GO:1990314)
0.1	0.2	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.0	0.2	GO:0009957	epidermal cell fate specification(GO:0009957)
0.0	0.1	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0	0.1	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.1	GO:0046469	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.1	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.0	0.2	GO:0008626	granzyme-mediated apoptotic signaling pathway(GO:0008626)
0.0	0.2	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.0	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.3	GO:0021960	anterior commissure morphogenesis(GO:0021960)
0.0	0.1	GO:0010912	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.3	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.2	GO:0009137	purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.0	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.2	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.2	GO:1902101	positive regulation of mitotic metaphase/anaphase transition(GO:0045842) positive regulation of metaphase/anaphase transition of cell cycle(GO:1902101)
0.0	0.1	GO:0046061	dATP catabolic process(GO:0046061)
0.0	0.1	GO:0046865	retinol transport(GO:0034633) isoprenoid transport(GO:0046864) terpenoid transport(GO:0046865)
0.0	0.1	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.1	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.2	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.2	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.1	GO:0018992	germ-line sex determination(GO:0018992)
0.0	0.2	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0032261	purine nucleotide salvage(GO:0032261) IMP salvage(GO:0032264)
0.0	0.1	GO:2000481	positive regulation of cAMP-dependent protein kinase activity(GO:2000481)
0.0	0.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.1	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.3	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.1	GO:0034756	regulation of iron ion transport(GO:0034756)
0.0	0.3	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.1	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0	0.2	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.0	GO:0033122	negative regulation of purine nucleotide catabolic process(GO:0033122)
0.0	0.1	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.1	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.0	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:0010255	carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255)
0.0	0.1	GO:0045347	negative regulation of MHC class II biosynthetic process(GO:0045347)
0.0	0.2	GO:1904354	negative regulation of telomere capping(GO:1904354)
0.0	0.1	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.0	0.1	GO:0035973	aggrephagy(GO:0035973)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.1	GO:0044026	DNA hypermethylation(GO:0044026)
0.0	0.0	GO:0014732	skeletal muscle atrophy(GO:0014732)
0.0	0.1	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.2	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0	0.1	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.1	GO:0060287	epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
0.0	0.1	GO:0032910	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.0	0.1	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.0	GO:0035284	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.1	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0060066	oviduct development(GO:0060066)
0.0	0.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.2	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.1	GO:0000320	re-entry into mitotic cell cycle(GO:0000320)
0.0	0.1	GO:0039534	negative regulation of MDA-5 signaling pathway(GO:0039534)
0.0	0.3	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0	0.1	GO:0035166	post-embryonic hemopoiesis(GO:0035166)
0.0	0.0	GO:1902488	cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.0	0.1	GO:0032687	negative regulation of interferon-alpha production(GO:0032687)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.2	GO:0061179	negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0	0.1	GO:0032898	neurotrophin production(GO:0032898)
0.0	0.1	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:0051031	tRNA transport(GO:0051031)
0.0	0.1	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.1	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.1	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.1	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.0	0.1	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:0014745	negative regulation of muscle adaptation(GO:0014745)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0045054	constitutive secretory pathway(GO:0045054)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.3	GO:0050966	detection of mechanical stimulus involved in sensory perception of pain(GO:0050966)
0.0	0.1	GO:0021637	trigeminal nerve morphogenesis(GO:0021636) trigeminal nerve structural organization(GO:0021637)
0.0	0.2	GO:0051901	positive regulation of mitochondrial depolarization(GO:0051901)
0.0	0.1	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.0	0.1	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.0	GO:0060125	negative regulation of growth hormone secretion(GO:0060125)
0.0	0.0	GO:0098735	positive regulation of the force of heart contraction(GO:0098735)
0.0	0.0	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.0	GO:2000646	positive regulation of receptor catabolic process(GO:2000646)
0.0	0.1	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.1	GO:0050689	negative regulation of defense response to virus by host(GO:0050689)
0.0	0.3	GO:0060736	prostate gland growth(GO:0060736)
0.0	0.0	GO:0070836	caveola assembly(GO:0070836)
0.0	0.1	GO:1904139	microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0	0.3	GO:0044406	adhesion of symbiont to host(GO:0044406)
0.0	0.0	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.0	0.0	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:0003097	renal water transport(GO:0003097)
0.0	0.0	GO:0030423	targeting of mRNA for destruction involved in RNA interference(GO:0030423)
0.0	0.0	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.0	0.1	GO:0051122	hepoxilin metabolic process(GO:0051121) hepoxilin biosynthetic process(GO:0051122)
0.0	0.1	GO:0023041	neuronal signal transduction(GO:0023041)
0.0	0.4	GO:0003416	endochondral bone growth(GO:0003416)
0.0	0.1	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:0060178	regulation of exocyst localization(GO:0060178)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0032876	negative regulation of DNA endoreduplication(GO:0032876)
0.0	0.1	GO:0036462	TRAIL-activated apoptotic signaling pathway(GO:0036462)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0071476	cellular hypotonic response(GO:0071476)
0.0	0.2	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.0	0.1	GO:0018101	protein citrullination(GO:0018101)
0.0	0.1	GO:1903275	positive regulation of sodium ion export(GO:1903275) positive regulation of sodium ion export from cell(GO:1903278)
0.0	0.1	GO:0051697	protein delipidation(GO:0051697)
0.0	0.1	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.0	0.4	GO:0071357	cellular response to type I interferon(GO:0071357)
0.0	0.2	GO:0070269	pyroptosis(GO:0070269)
0.0	0.0	GO:0042939	glutathione transport(GO:0034635) tripeptide transport(GO:0042939)
0.0	0.1	GO:0019240	citrulline biosynthetic process(GO:0019240)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.1	GO:0090091	positive regulation of extracellular matrix disassembly(GO:0090091)
0.0	0.3	GO:0006907	pinocytosis(GO:0006907)
0.0	0.0	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.0	GO:0010994	regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.0	0.1	GO:1904415	regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.0	0.1	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.0	0.1	GO:2000359	regulation of binding of sperm to zona pellucida(GO:2000359)
0.0	0.1	GO:0035822	meiotic gene conversion(GO:0006311) gene conversion(GO:0035822)
0.0	0.1	GO:0090336	positive regulation of brown fat cell differentiation(GO:0090336)
0.0	0.1	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.0	0.1	GO:0034627	'de novo' NAD biosynthetic process(GO:0034627)
0.0	0.1	GO:0010878	cholesterol storage(GO:0010878)
0.0	0.1	GO:0002892	type IIa hypersensitivity(GO:0001794) regulation of type IIa hypersensitivity(GO:0001796) positive regulation of type IIa hypersensitivity(GO:0001798) type II hypersensitivity(GO:0002445) regulation of type II hypersensitivity(GO:0002892) positive regulation of type II hypersensitivity(GO:0002894)
0.0	0.0	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608)
0.0	0.1	GO:0016561	protein import into peroxisome matrix, translocation(GO:0016561)
0.0	0.0	GO:0045113	regulation of integrin biosynthetic process(GO:0045113)
0.0	0.1	GO:0061370	testosterone biosynthetic process(GO:0061370)
0.0	0.3	GO:2000251	positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.0	0.1	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.2	GO:0031115	negative regulation of microtubule polymerization(GO:0031115)
0.0	0.2	GO:0032793	positive regulation of CREB transcription factor activity(GO:0032793)
0.0	0.1	GO:0080154	regulation of fertilization(GO:0080154)
0.0	0.1	GO:0010566	regulation of ketone biosynthetic process(GO:0010566)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:1902004	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0	0.1	GO:0043456	regulation of pentose-phosphate shunt(GO:0043456)
0.0	0.0	GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585)
0.0	0.1	GO:1904220	regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) regulation of serine C-palmitoyltransferase activity(GO:1904220) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
0.0	0.3	GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II(GO:0019886)
0.0	0.1	GO:0070601	centromeric sister chromatid cohesion(GO:0070601)
0.0	0.0	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.1	GO:0070340	detection of bacterial lipopeptide(GO:0070340)
0.0	0.0	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.0	GO:0009051	pentose-phosphate shunt, oxidative branch(GO:0009051)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:1902287	semaphorin-plexin signaling pathway involved in axon guidance(GO:1902287)
0.0	0.1	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.1	GO:0071397	cellular response to cholesterol(GO:0071397)
0.0	0.1	GO:0070070	proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0	0.0	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0	0.1	GO:0031657	regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle(GO:0031657)
0.0	0.0	GO:0006382	adenosine to inosine editing(GO:0006382)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.0	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.1	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.0	GO:1903012	positive regulation of bone development(GO:1903012)
0.0	0.1	GO:0042256	mature ribosome assembly(GO:0042256)
0.0	0.1	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.0	GO:1902988	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.1	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.0	0.1	GO:0043504	mitochondrial DNA repair(GO:0043504)
0.0	0.1	GO:0070175	positive regulation of enamel mineralization(GO:0070175)
0.0	0.0	GO:0014707	branchiomeric skeletal muscle development(GO:0014707)
0.0	0.1	GO:0006658	phosphatidylserine metabolic process(GO:0006658)
0.0	0.1	GO:0000056	ribosomal small subunit export from nucleus(GO:0000056)
0.0	0.1	GO:0019244	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0	0.2	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.3	GO:0001574	ganglioside biosynthetic process(GO:0001574)
0.0	0.1	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.0	0.1	GO:0060352	cell adhesion molecule production(GO:0060352)
0.0	0.0	GO:0010744	positive regulation of macrophage derived foam cell differentiation(GO:0010744)
0.0	0.2	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.0	GO:0035262	gonad morphogenesis(GO:0035262)
0.0	0.0	GO:0097384	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0097343	ripoptosome assembly(GO:0097343) ripoptosome assembly involved in necroptotic process(GO:1901026)
0.0	0.1	GO:0018401	peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.0	0.1	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0	0.1	GO:0060971	embryonic heart tube left/right pattern formation(GO:0060971)
0.0	0.1	GO:0035562	negative regulation of chromatin binding(GO:0035562)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:2000049	positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.0	0.0	GO:0070777	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.0	GO:0002254	kinin cascade(GO:0002254)
0.0	0.1	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0	0.0	GO:0032696	negative regulation of interleukin-13 production(GO:0032696)
0.0	0.0	GO:0033686	positive regulation of luteinizing hormone secretion(GO:0033686)
0.0	0.0	GO:0060618	nipple development(GO:0060618)
0.0	0.2	GO:0019363	pyridine nucleotide biosynthetic process(GO:0019363)
0.0	0.2	GO:0015937	coenzyme A biosynthetic process(GO:0015937)
0.0	0.0	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0	0.1	GO:0006742	NADP catabolic process(GO:0006742)
0.0	0.0	GO:0002838	negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
0.0	0.1	GO:0060406	positive regulation of penile erection(GO:0060406)
0.0	0.0	GO:2000587	regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000586) negative regulation of platelet-derived growth factor receptor-beta signaling pathway(GO:2000587)
0.0	0.0	GO:0048143	astrocyte activation(GO:0048143)
0.0	0.0	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0042737	drug catabolic process(GO:0042737)
0.0	0.1	GO:0001922	B-1 B cell homeostasis(GO:0001922)
0.0	0.1	GO:0007406	negative regulation of neuroblast proliferation(GO:0007406)
0.0	0.0	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.0	0.1	GO:0033625	positive regulation of integrin activation(GO:0033625)
0.0	0.1	GO:0060539	diaphragm development(GO:0060539)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.1	GO:0034340	response to type I interferon(GO:0034340)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.1	GO:0046909	intermembrane transport(GO:0046909)
0.0	0.0	GO:1900122	positive regulation of receptor binding(GO:1900122)
0.0	0.1	GO:0070345	negative regulation of fat cell proliferation(GO:0070345)
0.0	0.0	GO:0001844	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:0001844)
0.0	0.0	GO:1904058	positive regulation of sensory perception of pain(GO:1904058)
0.0	0.0	GO:0035962	response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.0	0.1	GO:0035590	purinergic nucleotide receptor signaling pathway(GO:0035590)
0.0	0.1	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0	0.2	GO:0043011	myeloid dendritic cell differentiation(GO:0043011)
0.0	0.0	GO:0002331	pre-B cell allelic exclusion(GO:0002331)
0.0	0.0	GO:0032808	lacrimal gland development(GO:0032808)
0.0	0.0	GO:0072319	vesicle uncoating(GO:0072319)
0.0	0.0	GO:0051106	regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
0.0	0.1	GO:0061684	chaperone-mediated autophagy(GO:0061684)
0.0	0.1	GO:1901030	positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901030)
0.0	0.0	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0	0.1	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.1	GO:0071763	nuclear membrane organization(GO:0071763)
0.0	0.4	GO:0008045	motor neuron axon guidance(GO:0008045)
0.0	0.0	GO:0051088	PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
0.0	0.0	GO:0098700	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.1	GO:1902969	mitotic DNA replication(GO:1902969)
0.0	0.1	GO:0042759	long-chain fatty acid biosynthetic process(GO:0042759)
0.0	0.4	GO:1903146	regulation of mitophagy(GO:1903146)
0.0	0.1	GO:1901725	regulation of histone deacetylase activity(GO:1901725)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.1	GO:0018103	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.0	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.0	0.0	GO:2000173	negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0	0.0	GO:0010166	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.0	GO:1904263	positive regulation of TORC1 signaling(GO:1904263)
0.0	0.0	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.0	GO:0046103	inosine biosynthetic process(GO:0046103)
0.0	0.1	GO:0051549	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.1	GO:1990414	replication-born double-strand break repair via sister chromatid exchange(GO:1990414)
0.0	0.0	GO:0016259	selenocysteine metabolic process(GO:0016259)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0052490	negative regulation by symbiont of host apoptotic process(GO:0033668) modulation of programmed cell death in other organism(GO:0044531) modulation of apoptotic process in other organism(GO:0044532) modulation by symbiont of host programmed cell death(GO:0052040) negative regulation by symbiont of host programmed cell death(GO:0052041) modulation by symbiont of host apoptotic process(GO:0052150) modulation of programmed cell death in other organism involved in symbiotic interaction(GO:0052248) modulation by organism of apoptotic process in other organism involved in symbiotic interaction(GO:0052433) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.0	0.1	GO:0031443	fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.0	0.0	GO:0001834	trophectodermal cell proliferation(GO:0001834)
0.0	0.1	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0002076	osteoblast development(GO:0002076)
0.0	0.0	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0042448	progesterone metabolic process(GO:0042448)
0.0	0.1	GO:0030432	peristalsis(GO:0030432)
0.0	0.0	GO:0010612	regulation of cardiac muscle adaptation(GO:0010612) regulation of cardiac muscle hypertrophy in response to stress(GO:1903242)
0.0	0.1	GO:0038030	non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030)
0.0	0.0	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.0	GO:0003164	His-Purkinje system development(GO:0003164)
0.0	0.0	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.0	GO:0000491	small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492)
0.0	0.0	GO:1900084	regulation of peptidyl-tyrosine autophosphorylation(GO:1900084) positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.0	0.0	GO:1902177	positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902177)
0.0	0.0	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.0	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0	0.0	GO:0072757	cellular response to camptothecin(GO:0072757)
0.0	0.1	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.1	GO:0009264	deoxyribonucleotide catabolic process(GO:0009264)
0.0	0.1	GO:0033033	negative regulation of myeloid cell apoptotic process(GO:0033033)
0.0	0.1	GO:2000270	negative regulation of fibroblast apoptotic process(GO:2000270)
0.0	0.0	GO:0021986	epithalamus development(GO:0021538) habenula development(GO:0021986)
0.0	0.0	GO:1902474	positive regulation of protein localization to synapse(GO:1902474)
0.0	0.1	GO:0033578	protein glycosylation in Golgi(GO:0033578)
0.0	0.1	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:0030242	pexophagy(GO:0030242)
0.0	0.0	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.0	0.0	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.0	GO:0060623	regulation of chromosome condensation(GO:0060623)
0.0	0.0	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.0	GO:0090245	axis elongation involved in somitogenesis(GO:0090245)
0.0	0.0	GO:0032201	telomere maintenance via semi-conservative replication(GO:0032201)
0.0	0.0	GO:1901838	positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.0	0.0	GO:0000087	mitotic M phase(GO:0000087)
0.0	0.0	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
0.0	0.0	GO:0032286	central nervous system myelin maintenance(GO:0032286)
0.0	0.1	GO:0090043	regulation of tubulin deacetylation(GO:0090043)
0.0	0.0	GO:0033632	regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0	0.0	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.0	GO:0010387	COP9 signalosome assembly(GO:0010387)
0.0	0.1	GO:0045925	positive regulation of female receptivity(GO:0045925)
0.0	0.1	GO:0007008	outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.0	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0031053	primary miRNA processing(GO:0031053)
0.0	0.1	GO:0033299	secretion of lysosomal enzymes(GO:0033299)
0.0	0.0	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0046827	positive regulation of protein export from nucleus(GO:0046827)
0.0	0.1	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.0	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.0	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.0	0.0	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.0	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.0	GO:0070842	aggresome assembly(GO:0070842)
0.0	0.0	GO:0043654	recognition of apoptotic cell(GO:0043654)
0.0	0.1	GO:2000973	regulation of pro-B cell differentiation(GO:2000973)
0.0	0.1	GO:0034393	positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.0	0.0	GO:0007386	compartment pattern specification(GO:0007386)
0.0	0.0	GO:0002874	regulation of chronic inflammatory response to antigenic stimulus(GO:0002874)
0.0	0.0	GO:0048254	snoRNA localization(GO:0048254)
0.0	0.1	GO:0030174	regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.0	0.1	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.1	GO:0060346	bone trabecula formation(GO:0060346)
0.0	0.0	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.0	GO:0070375	ERK5 cascade(GO:0070375)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.2	GO:0044458	motile cilium assembly(GO:0044458)
0.0	0.0	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.0	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.1	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
0.0	0.1	GO:0045953	negative regulation of natural killer cell mediated cytotoxicity(GO:0045953)
0.0	0.1	GO:0001866	NK T cell proliferation(GO:0001866)
0.0	0.1	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.1	GO:0097049	motor neuron apoptotic process(GO:0097049)
0.0	0.1	GO:0032926	negative regulation of activin receptor signaling pathway(GO:0032926)
0.0	0.0	GO:0031666	positive regulation of lipopolysaccharide-mediated signaling pathway(GO:0031666)
0.0	0.2	GO:2001222	regulation of neuron migration(GO:2001222)
0.0	0.0	GO:0040009	regulation of growth rate(GO:0040009)
0.0	0.0	GO:0051599	response to hydrostatic pressure(GO:0051599)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.4	GO:0072558	NLRP1 inflammasome complex(GO:0072558)
0.1	0.4	GO:0045098	type III intermediate filament(GO:0045098)
0.1	0.2	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.4	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	0.1	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.2	GO:1990357	terminal web(GO:1990357)
0.0	0.2	GO:0071203	WASH complex(GO:0071203)
0.0	0.1	GO:0035061	interchromatin granule(GO:0035061)
0.0	0.2	GO:0044194	cytolytic granule(GO:0044194)
0.0	0.2	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.2	GO:0031313	extrinsic component of endosome membrane(GO:0031313)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.2	GO:0005826	actomyosin contractile ring(GO:0005826)
0.0	0.5	GO:0043034	costamere(GO:0043034)
0.0	0.3	GO:0042405	nuclear inclusion body(GO:0042405)
0.0	0.1	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.0	0.2	GO:0035032	phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0	0.2	GO:0042613	MHC class II protein complex(GO:0042613)
0.0	0.3	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:1990462	omegasome(GO:1990462)
0.0	0.4	GO:0033270	paranode region of axon(GO:0033270)
0.0	0.2	GO:0090533	cation-transporting ATPase complex(GO:0090533)
0.0	0.1	GO:1990246	uniplex complex(GO:1990246)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.2	GO:0000813	ESCRT I complex(GO:0000813)
0.0	0.3	GO:0071565	nBAF complex(GO:0071565)
0.0	0.3	GO:0005641	nuclear envelope lumen(GO:0005641)
0.0	0.1	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0034362	low-density lipoprotein particle(GO:0034362)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.1	GO:0045180	basal cortex(GO:0045180)
0.0	0.1	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0	0.1	GO:0033263	CORVET complex(GO:0033263)
0.0	0.3	GO:0070971	endoplasmic reticulum exit site(GO:0070971)
0.0	0.1	GO:0030670	phagocytic vesicle membrane(GO:0030670)
0.0	0.1	GO:0000125	PCAF complex(GO:0000125)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.0	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)
0.0	0.0	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.0	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.0	GO:0031264	death-inducing signaling complex(GO:0031264)
0.0	0.0	GO:0038037	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.2	GO:0016471	vacuolar proton-transporting V-type ATPase complex(GO:0016471)
0.0	0.0	GO:1990761	growth cone lamellipodium(GO:1990761)
0.0	0.1	GO:0070820	tertiary granule(GO:0070820)
0.0	0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.1	GO:0031415	NatA complex(GO:0031415)
0.0	0.0	GO:0036195	muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.0	0.0	GO:0072559	NLRP3 inflammasome complex(GO:0072559)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.2	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.0	GO:0071817	MMXD complex(GO:0071817)
0.0	0.1	GO:0072557	IPAF inflammasome complex(GO:0072557)
0.0	0.4	GO:0031985	Golgi cisterna(GO:0031985)
0.0	0.1	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.0	GO:0000444	MIS12/MIND type complex(GO:0000444)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.0	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.0	GO:0005726	perichromatin fibrils(GO:0005726)
0.0	0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.0	GO:0043511	inhibin complex(GO:0043511)
0.0	0.1	GO:0000801	central element(GO:0000801)
0.0	0.1	GO:0071986	Ragulator complex(GO:0071986)
0.0	0.0	GO:0020018	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0	0.0	GO:0000322	storage vacuole(GO:0000322)
0.0	0.0	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.1	GO:0031209	SCAR complex(GO:0031209)
0.0	0.1	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	0.3	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.1	GO:0016600	flotillin complex(GO:0016600)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.7	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.5	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.1	0.7	GO:0030235	nitric-oxide synthase regulator activity(GO:0030235)
0.1	0.3	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.1	0.4	GO:0005131	growth hormone receptor binding(GO:0005131)
0.1	0.2	GO:0097108	hedgehog family protein binding(GO:0097108)
0.1	0.2	GO:0070052	collagen V binding(GO:0070052)
0.1	0.2	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.1	0.2	GO:0047623	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1	0.2	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.4	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.0	0.1	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.0	0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.1	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.5	GO:0034987	immunoglobulin receptor binding(GO:0034987)
0.0	0.2	GO:0043262	adenosine-diphosphatase activity(GO:0043262)
0.0	0.1	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.2	GO:0042609	CD4 receptor binding(GO:0042609)
0.0	0.3	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.1	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.0	0.2	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.2	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.2	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.1	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.2	GO:0050656	3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0	0.2	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.1	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.0	0.2	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.0	GO:0001224	RNA polymerase II transcription cofactor binding(GO:0001224)
0.0	0.1	GO:0032554	purine deoxyribonucleotide binding(GO:0032554)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.3	GO:0018636	phenanthrene 9,10-monooxygenase activity(GO:0018636)
0.0	0.2	GO:0036122	BMP binding(GO:0036122)
0.0	0.2	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0051575	5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.0	GO:0016015	morphogen activity(GO:0016015)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0030021	extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.0	0.1	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.0	0.2	GO:0001608	G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0	0.1	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
0.0	0.1	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.3	GO:0001222	transcription corepressor binding(GO:0001222)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0001602	pancreatic polypeptide receptor activity(GO:0001602)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.2	GO:0005338	nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.0	0.2	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.1	GO:0004668	protein-arginine deiminase activity(GO:0004668)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.3	GO:0015299	solute:proton antiporter activity(GO:0015299)
0.0	0.1	GO:0034902	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.1	GO:0022858	L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0	0.1	GO:0004800	thyroxine 5'-deiodinase activity(GO:0004800)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.2	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.2	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.2	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.1	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.3	GO:0023026	MHC class II protein complex binding(GO:0023026)
0.0	0.1	GO:0005329	dopamine transmembrane transporter activity(GO:0005329)
0.0	0.1	GO:0030984	kininogen binding(GO:0030984)
0.0	0.1	GO:0036435	K48-linked polyubiquitin binding(GO:0036435)
0.0	0.2	GO:0031386	protein tag(GO:0031386)
0.0	0.3	GO:0005521	lamin binding(GO:0005521)
0.0	0.1	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0	0.2	GO:0046977	TAP binding(GO:0046977)
0.0	0.1	GO:0035256	G-protein coupled glutamate receptor binding(GO:0035256)
0.0	0.2	GO:0070182	DNA polymerase binding(GO:0070182)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.1	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.1	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.2	GO:0019215	intermediate filament binding(GO:0019215)
0.0	0.3	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.3	GO:0017134	fibroblast growth factor binding(GO:0017134)
0.0	0.0	GO:0035368	selenocysteine insertion sequence binding(GO:0035368)
0.0	0.1	GO:0008410	CoA-transferase activity(GO:0008410)
0.0	0.1	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.3	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.0	0.0	GO:0004461	lactose synthase activity(GO:0004461)
0.0	0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.2	GO:0030169	low-density lipoprotein particle binding(GO:0030169)
0.0	0.0	GO:0047276	N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.0	0.3	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.0	GO:0015119	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.0	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.0	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.2	GO:0008574	ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.0	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	0.1	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.1	GO:0031433	telethonin binding(GO:0031433)
0.0	0.0	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	0.1	GO:0031545	peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.0	0.3	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.2	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.1	GO:0004017	adenylate kinase activity(GO:0004017)
0.0	0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	0.0	GO:0016882	cyclo-ligase activity(GO:0016882)
0.0	0.1	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.0	0.3	GO:0031435	mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.0	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.0	GO:0045505	dynein intermediate chain binding(GO:0045505)
0.0	0.1	GO:0047184	1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184)
0.0	0.1	GO:0070815	peptidyl-lysine 5-dioxygenase activity(GO:0070815)
0.0	0.1	GO:0032027	myosin light chain binding(GO:0032027)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.1	GO:0005283	sodium:amino acid symporter activity(GO:0005283)
0.0	0.2	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.2	GO:0050750	low-density lipoprotein particle receptor binding(GO:0050750)
0.0	0.0	GO:0015111	iodide transmembrane transporter activity(GO:0015111)
0.0	0.1	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.2	GO:0046703	natural killer cell lectin-like receptor binding(GO:0046703)
0.0	0.1	GO:0019841	retinol binding(GO:0019841)
0.0	0.2	GO:0019789	SUMO transferase activity(GO:0019789)
0.0	0.0	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.3	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
0.0	0.2	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.2	GO:0005537	mannose binding(GO:0005537)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.0	GO:0008506	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0005391	sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0	0.0	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.0	GO:0005534	galactose binding(GO:0005534)
0.0	0.0	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.1	GO:0001614	purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.0	0.1	GO:0042288	MHC class I protein binding(GO:0042288)
0.0	0.2	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	0.0	GO:0004967	glucagon receptor activity(GO:0004967)
0.0	0.1	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	0.0	GO:0031698	beta-2 adrenergic receptor binding(GO:0031698)
0.0	0.1	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.0	0.1	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.0	GO:0019961	interferon binding(GO:0019961)
0.0	0.0	GO:0005143	interleukin-12 receptor binding(GO:0005143)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.0	GO:0004351	glutamate decarboxylase activity(GO:0004351)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.1	0.3	ST IL 13 PATHWAY	Interleukin 13 (IL-13) Pathway
0.0	0.0	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	0.1	PID AVB3 OPN PATHWAY	Osteopontin-mediated events
0.0	0.5	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.0	0.2	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.0	0.5	PID ALK1 PATHWAY	ALK1 signaling events
0.0	0.3	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	0.0	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.0	0.1	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	0.2	PID ANTHRAX PATHWAY	Cellular roles of Anthrax toxin
0.0	0.1	PID IL2 1PATHWAY	IL2-mediated signaling events
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.0	PID IL23 PATHWAY	IL23-mediated signaling events
0.0	0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.0	0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.2	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.0	0.0	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.0	0.4	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.2	PID TCPTP PATHWAY	Signaling events mediated by TCPTP
0.0	0.1	PID FGF PATHWAY	FGF signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.7	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.0	0.2	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.6	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.1	REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION	Genes involved in APOBEC3G mediated resistance to HIV-1 infection
0.0	0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.4	REACTOME REGULATION OF IFNG SIGNALING	Genes involved in Regulation of IFNG signaling
0.0	0.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.2	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.0	REACTOME SIGNALING BY NOTCH2	Genes involved in Signaling by NOTCH2
0.0	0.3	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.3	REACTOME P2Y RECEPTORS	Genes involved in P2Y receptors
0.0	0.2	REACTOME CREATION OF C4 AND C2 ACTIVATORS	Genes involved in Creation of C4 and C2 activators
0.0	0.2	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.2	REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Extrinsic Pathway for Apoptosis
0.0	0.1	REACTOME ENDOSOMAL VACUOLAR PATHWAY	Genes involved in Endosomal/Vacuolar pathway
0.0	0.2	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.2	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.3	REACTOME REGULATION OF IFNA SIGNALING	Genes involved in Regulation of IFNA signaling
0.0	0.0	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.3	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.0	0.2	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.2	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.0	0.4	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.4	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.0	0.3	REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS	Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.0	0.1	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
0.0	0.3	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.0	REACTOME ACYL CHAIN REMODELLING OF PS	Genes involved in Acyl chain remodelling of PS
0.0	0.4	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.0	0.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.0	0.1	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.3	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA
0.0	0.2	REACTOME AMINE DERIVED HORMONES	Genes involved in Amine-derived hormones
0.0	0.2	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.0	0.2	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.0	0.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.2	REACTOME EGFR DOWNREGULATION	Genes involved in EGFR downregulation
0.0	0.2	REACTOME CA DEPENDENT EVENTS	Genes involved in Ca-dependent events
0.0	0.1	REACTOME ANDROGEN BIOSYNTHESIS	Genes involved in Androgen biosynthesis
0.0	0.0	REACTOME PLC BETA MEDIATED EVENTS	Genes involved in PLC beta mediated events
0.0	0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.0	0.0	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors

Results for Irf4

Z-value: 2.55

Motif logo

Transcription factors associated with Irf4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Irf4 motif across conditions

Conditions sorted by the z-value of the Irf4 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: