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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Irf5_Irf6

Z-value: 0.93

Motif logo

Transcription factors associated with Irf5_Irf6

Gene Symbol	Gene ID	Gene Info
Irf5 Ensembl NCBI MGI UniProt	ENSMUSG00000029771.6	Irf5
Irf6 Ensembl NCBI MGI UniProt	ENSMUSG00000026638.9	Irf6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Irf5	chr6_29523942_29524117	2596	0.161909	-0.95	3.8e-03	Click!
Irf5	chr6_29538799_29539193	2150	0.196327	-0.89	1.8e-02	Click!
Irf5	chr6_29522778_29522945	3764	0.131636	-0.76	7.8e-02	Click!
Irf5	chr6_29522974_29523209	3534	0.135510	-0.74	9.1e-02	Click!
Irf5	chr6_29526985_29527412	490	0.680948	0.70	1.2e-01	Click!
Irf6	chr1_193170032_193170189	1607	0.218081	-0.90	1.5e-02	Click!
Irf6	chr1_193153538_193153923	576	0.632924	0.89	1.7e-02	Click!
Irf6	chr1_193169761_193169948	1351	0.254104	0.65	1.6e-01	Click!
Irf6	chr1_193153972_193154171	917	0.438303	0.60	2.1e-01	Click!
Irf6	chr1_193159245_193159427	2667	0.165053	-0.54	2.7e-01	Click!

Activity of the Irf5_Irf6 motif across conditions

Conditions sorted by the z-value of the Irf5_Irf6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_6206187_6206411	0.75	Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	10819	0.23
chr6_88641424_88641714	0.69	Kbtbd12	kelch repeat and BTB (POZ) domain containing 12	3619	0.23
chr19_46645853_46646011	0.62	Gm36602	predicted gene, 36602	20194	0.11
chr9_65675680_65676009	0.56	Oaz2	ornithine decarboxylase antizyme 2	704	0.64
chr13_31808871_31809301	0.55	Foxc1	forkhead box C1	2453	0.26
chr6_134538835_134539031	0.54	Lrp6	low density lipoprotein receptor-related protein 6	2781	0.28
chr13_101811863_101812015	0.53	Gm19108	predicted gene, 19108	30367	0.15
chr9_56929068_56929260	0.48	Snx33	sorting nexin 33	793	0.44
chr13_13994363_13994818	0.45	B3galnt2	UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2	170	0.92
chr2_147961290_147961525	0.44	9030622O22Rik	RIKEN cDNA 9030622O22 gene	14778	0.22
chr11_101070404_101070591	0.44	Naglu	alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)	485	0.62
chr9_14381410_14381579	0.44	Endod1	endonuclease domain containing 1	13	0.96
chr1_138617784_138617983	0.42	Nek7	NIMA (never in mitosis gene a)-related expressed kinase 7	1791	0.35
chr9_9230047_9230379	0.42	Gm16833	predicted gene, 16833	6075	0.24
chr11_88614641_88614847	0.40	Msi2	musashi RNA-binding protein 2	24597	0.21
chr1_130761129_130761587	0.39	Gm28856	predicted gene 28856	5026	0.11
chr2_128377797_128377975	0.39	Morrbid	myeloid RNA regulator of BCL2L11 induced cell death	25079	0.18
chr6_108506487_108506825	0.39	Itpr1	inositol 1,4,5-trisphosphate receptor 1	1657	0.32
chr1_10039266_10039475	0.37	Cspp1	centrosome and spindle pole associated protein 1	397	0.7
chr11_119109577_119109728	0.37	Gm11754	predicted gene 11754	1773	0.27
chr1_84051880_84052058	0.37	Pid1	phosphotyrosine interaction domain containing 1	1284	0.56
chr14_46277334_46277485	0.35	Gm15217	predicted gene 15217	102005	0.06
chr9_111138334_111138716	0.32	Lrrfip2	leucine rich repeat (in FLII) interacting protein 2	18850	0.15
chr16_24061978_24062260	0.32	Gm46545	predicted gene, 46545	20571	0.15
chr4_59546423_59546594	0.32	Ptbp3	polypyrimidine tract binding protein 3	2229	0.23
chr8_23207373_23207572	0.31	Gpat4	glycerol-3-phosphate acyltransferase 4	873	0.36
chr13_119966643_119967735	0.31	Gm20784	predicted gene, 20784	4945	0.11
chr16_6901477_6901805	0.31	Rbfox1	RNA binding protein, fox-1 homolog (C. elegans) 1	92419	0.1
chr13_51101532_51101693	0.30	Spin1	spindlin 1	732	0.73
chr5_125189474_125189632	0.30	Ncor2	nuclear receptor co-repressor 2	10334	0.21
chr13_60508473_60508632	0.30	A530001N23Rik	RIKEN cDNA A530001N23 gene	19744	0.15
chr19_47311513_47311735	0.29	Sh3pxd2a	SH3 and PX domains 2A	3127	0.23
chr19_29367023_29367182	0.29	Plgrkt	plasminogen receptor, C-terminal lysine transmembrane protein	206	0.65
chr4_123645434_123645623	0.28	Gm12926	predicted gene 12926	15233	0.13
chr1_105356184_105356368	0.28	Gm17634	predicted gene, 17634	269	0.62
chr4_59452546_59452697	0.28	Susd1	sushi domain containing 1	13988	0.19
chr19_5529673_5529945	0.28	Gm31166	predicted gene, 31166	1821	0.14
chr2_38225178_38225332	0.27	Gm44455	predicted gene, 44455	133	0.96
chr14_64154802_64154953	0.26	9630015K15Rik	RIKEN cDNA 9630015K15 gene	38563	0.11
chr10_111490434_111490604	0.26	Nap1l1	nucleosome assembly protein 1-like 1	326	0.84
chr5_130204701_130204852	0.26	Rabgef1	RAB guanine nucleotide exchange factor (GEF) 1	2277	0.16
chr5_129715571_129715984	0.25	Mrps17	mitochondrial ribosomal protein S17	80	0.95
chr10_7589267_7589435	0.25	Lrp11	low density lipoprotein receptor-related protein 11	449	0.78
chr9_27106238_27106393	0.25	Gm48796	predicted gene, 48796	7764	0.17
chr19_46140028_46140457	0.25	Pitx3	paired-like homeodomain transcription factor 3	741	0.53
chr4_15066667_15066833	0.25	Gm11844	predicted gene 11844	44168	0.16
chr18_44661527_44661720	0.25	A930012L18Rik	RIKEN cDNA A930012L18 gene	42	0.93
chr4_102583077_102583228	0.24	Pde4b	phosphodiesterase 4B, cAMP specific	4406	0.34
chr5_99978647_99978803	0.24	Hnrnpd	heterogeneous nuclear ribonucleoprotein D	101	0.78
chr16_17838275_17838426	0.24	Car15	carbonic anhydrase 15	14	0.95
chr5_99269909_99270098	0.24	Gm35394	predicted gene, 35394	4092	0.27
chr15_74967628_74968021	0.24	Ly6e	lymphocyte antigen 6 complex, locus E	11269	0.08
chr13_119966017_119966201	0.23	Gm20784	predicted gene, 20784	3865	0.12
chr5_87573106_87573296	0.23	Sult1d1	sulfotransferase family 1D, member 1	4174	0.13
chr8_61927981_61928360	0.23	Ddx60	DEAD (Asp-Glu-Ala-Asp) box polypeptide 60	81	0.58
chr6_13870954_13871322	0.22	2610001J05Rik	RIKEN cDNA 2610001J05 gene	327	0.54
chr10_20150520_20150679	0.22	Map7	microtubule-associated protein 7	1601	0.37
chr9_55541381_55541949	0.22	Isl2	insulin related protein 2 (islet 2)	458	0.61
chr7_13005790_13006506	0.22	Zbtb45	zinc finger and BTB domain containing 45	3652	0.09
chr3_121531769_121531936	0.22	A530020G20Rik	RIKEN cDNA A530020G20 gene	173	0.82
chr7_30955354_30955627	0.22	Usf2	upstream transcription factor 2	40	0.79
chr3_131552705_131552871	0.22	Papss1	3'-phosphoadenosine 5'-phosphosulfate synthase 1	11980	0.23
chr19_16029303_16029488	0.22	Rpl37-ps1	ribosomal protein 37, pseudogene 1	3944	0.23
chr10_20170266_20170434	0.22	Map7	microtubule-associated protein 7	430	0.82
chr14_11699956_11700511	0.22	Gm48602	predicted gene, 48602	67710	0.12
chr8_111299402_111299697	0.21	Rfwd3	ring finger and WD repeat domain 3	642	0.64
chr14_62557485_62557724	0.21	Fam124a	family with sequence similarity 124, member A	1829	0.24
chr10_127355157_127355314	0.21	Inhbe	inhibin beta-E	824	0.38
chr11_58100366_58100593	0.21	Gm12247	predicted gene 12247	2706	0.16
chr4_115057217_115057403	0.21	Tal1	T cell acute lymphocytic leukemia 1	128	0.95
chr17_6782237_6782457	0.21	Ezr	ezrin	437	0.8
chr1_131620226_131620377	0.21	Gm8532	predicted gene 8532	12668	0.14
chr7_139401907_139402067	0.21	Inpp5a	inositol polyphosphate-5-phosphatase A	1498	0.49
chr13_8651016_8651177	0.20	Gm48262	predicted gene, 48262	98076	0.06
chr4_33033624_33033916	0.20	Ube2j1	ubiquitin-conjugating enzyme E2J 1	2242	0.18
chr12_100158931_100159295	0.20	Nrde2	nrde-2 necessary for RNA interference, domain containing	535	0.7
chr13_60479839_60480430	0.20	Gm48500	predicted gene, 48500	1164	0.45
chr16_96363004_96363159	0.20	Igsf5	immunoglobulin superfamily, member 5	1287	0.33
chr15_98869205_98869356	0.20	Kmt2d	lysine (K)-specific methyltransferase 2D	1903	0.14
chr11_43767190_43767354	0.20	Ttc1	tetratricopeptide repeat domain 1	19264	0.19
chr2_27725053_27725318	0.20	Rxra	retinoid X receptor alpha	34	0.99
chr15_74955213_74955440	0.20	Ly6e	lymphocyte antigen 6 complex, locus E	66	0.93
chr3_145912337_145912507	0.20	Bcl10	B cell leukemia/lymphoma 10	10382	0.17
chr6_116240202_116240376	0.20	Washc2	WASH complex subunit 2`	14317	0.11
chr10_75187490_75187671	0.19	Bcr	BCR activator of RhoGEF and GTPase	11204	0.2
chr16_91043514_91043963	0.19	Paxbp1	PAX3 and PAX7 binding protein 1	426	0.63
chr5_145871647_145871798	0.19	Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	4969	0.18
chr3_27183172_27183371	0.19	Nceh1	neutral cholesterol ester hydrolase 1	267	0.91
chr8_35826443_35826604	0.19	Cldn23	claudin 23	36	0.97
chr18_75370151_75370534	0.19	Smad7	SMAD family member 7	366	0.87
chr11_69080646_69080973	0.19	Gm25371	predicted gene, 25371	5794	0.07
chr14_63247987_63248412	0.19	Gata4	GATA binding protein 4	2928	0.24
chr17_71485826_71486209	0.19	Gm18738	predicted gene, 18738	2625	0.16
chr5_72410672_72410832	0.18	Gm19560	predicted gene, 19560	1308	0.39
chr13_59556477_59556954	0.18	Agtpbp1	ATP/GTP binding protein 1	204	0.85
chr15_60823871_60824050	0.18	9930014A18Rik	RIKEN cDNA 9930014A18 gene	381	0.77
chr2_91084552_91084841	0.18	Spi1	spleen focus forming virus (SFFV) proviral integration oncogene	2288	0.17
chr2_93470457_93470622	0.18	Gm10804	predicted gene 10804	2100	0.3
chr4_98322017_98322210	0.18	0610025J13Rik	RIKEN cDNA 0610025J13 gene	665	0.68
chr10_12996840_12997182	0.18	Sf3b5	splicing factor 3b, subunit 5	8332	0.19
chr16_8736038_8736588	0.18	Usp7	ubiquitin specific peptidase 7	2029	0.28
chr15_65787239_65787398	0.18	Efr3a	EFR3 homolog A	270	0.94
chr19_25383146_25383377	0.18	Kank1	KN motif and ankyrin repeat domains 1	12042	0.21
chr6_126848563_126848769	0.17	Ndufa9	NADH:ubiquinone oxidoreductase subunit A9	459	0.74
chr18_26015437_26015603	0.17	Gm33228	predicted gene, 33228	3217	0.39
chr16_52081908_52082365	0.17	Gm23513	predicted gene, 23513	23011	0.21
chr2_31501565_31501761	0.17	Ass1	argininosuccinate synthetase 1	937	0.56
chr9_21031078_21031624	0.17	Icam5	intercellular adhesion molecule 5, telencephalin	722	0.27
chr10_9901181_9901520	0.17	Gm46210	predicted gene, 46210	37	0.79
chr6_3620652_3620816	0.17	Vps50	VPS50 EARP/GARPII complex subunit	26716	0.17
chr13_38122267_38122440	0.17	Dsp	desmoplakin	28941	0.13
chr3_85273227_85273668	0.16	1700036G14Rik	RIKEN cDNA 1700036G14 gene	44072	0.16
chr7_16738552_16738717	0.16	Ap2s1	adaptor-related protein complex 2, sigma 1 subunit	96	0.94
chr18_46280937_46281101	0.16	Pggt1b	protein geranylgeranyltransferase type I, beta subunit	26	0.97
chr4_101448515_101448685	0.16	Ak4	adenylate kinase 4	1377	0.4
chr3_60965282_60965682	0.16	P2ry1	purinergic receptor P2Y, G-protein coupled 1	37313	0.16
chr5_32469434_32469600	0.16	Gm43313	predicted gene 43313	2322	0.19
chr3_108114477_108114651	0.16	Gnat2	guanine nucleotide binding protein, alpha transducing 2	17321	0.08
chr8_85555887_85556054	0.15	Dnaja2	DnaJ heat shock protein family (Hsp40) member A2	626	0.69
chr8_12720450_12720739	0.15	Gm15348	predicted gene 15348	1467	0.36
chr3_28026863_28027216	0.15	Pld1	phospholipase D1	4223	0.33
chr11_5520050_5520258	0.15	Xbp1	X-box binding protein 1	505	0.71
chr12_55490259_55490936	0.15	Nfkbia	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	1213	0.45
chr6_134543337_134543527	0.15	Lrp6	low density lipoprotein receptor-related protein 6	1718	0.37
chr11_49064151_49064330	0.15	Tgtp2	T cell specific GTPase 2	34	0.95
chr1_151501177_151501494	0.15	Rnf2	ring finger protein 2	380	0.75
chr8_48733650_48734100	0.15	Tenm3	teneurin transmembrane protein 3	59185	0.14
chr10_75415055_75415209	0.15	Upb1	ureidopropionase, beta	5089	0.19
chr1_37890066_37890236	0.14	Mitd1	MIT, microtubule interacting and transport, domain containing 1	125	0.73
chr4_135269728_135270123	0.14	Clic4	chloride intracellular channel 4 (mitochondrial)	2889	0.19
chr8_93333775_93334133	0.14	Ces1g	carboxylesterase 1G	3354	0.19
chr1_134962882_134963043	0.14	Ube2t	ubiquitin-conjugating enzyme E2T	344	0.87
chr6_122819451_122819712	0.14	Foxj2	forkhead box J2	333	0.71
chr18_64338075_64338233	0.14	Onecut2	one cut domain, family member 2	1866	0.3
chr9_65193311_65193501	0.14	Parp16	poly (ADP-ribose) polymerase family, member 16	1947	0.21
chr7_39841847_39842021	0.14	4930558N11Rik	RIKEN cDNA 4930558N11 gene	44192	0.11
chr9_42262292_42262705	0.14	Sc5d	sterol-C5-desaturase	1702	0.34
chr8_110629373_110629540	0.14	Vac14	Vac14 homolog (S. cerevisiae)	10844	0.21
chr3_122274519_122274867	0.14	Dnttip2	deoxynucleotidyltransferase, terminal, interacting protein 2	275	0.82
chr2_72286436_72286609	0.14	Map3k20	mitogen-activated protein kinase kinase kinase 20	728	0.67
chr7_110894004_110894327	0.14	Gm16336	predicted gene 16336	10820	0.16
chr9_8043039_8043256	0.14	Cfap300	cilia and flagella associated protein 300	324	0.88
chr16_22259188_22259423	0.14	Tra2b	transformer 2 beta	317	0.83
chr3_65527969_65528149	0.14	4931440P22Rik	RIKEN cDNA 4931440P22 gene	125	0.75
chr4_150371202_150371353	0.14	Rere	arginine glutamic acid dipeptide (RE) repeats	35117	0.15
chr16_93816432_93816740	0.14	Dop1b	DOP1 leucine zipper like protein B	7152	0.14
chr7_92681661_92681812	0.14	Pcf11	PCF11 cleavage and polyadenylation factor subunit	11802	0.12
chr13_120096376_120096558	0.14	Gm21378	predicted gene, 21378	3865	0.15
chr5_100636918_100637077	0.14	Coq2	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	27422	0.12
chr7_97736977_97737173	0.14	Aqp11	aquaporin 11	863	0.54
chr1_51774175_51774474	0.13	Myo1b	myosin IB	2112	0.33
chr11_72690308_72690642	0.13	Ankfy1	ankyrin repeat and FYVE domain containing 1	469	0.8
chr4_56222157_56222524	0.13	2310081O03Rik	RIKEN cDNA 2310081O03 gene	2181	0.42
chr3_108022402_108022739	0.13	Gm12498	predicted gene 12498	2679	0.1
chr15_58415328_58415520	0.13	Fam91a1	family with sequence similarity 91, member A1	44	0.97
chr16_26505107_26505285	0.13	Tmem207	transmembrane protein 207	21566	0.21
chr5_136506363_136506567	0.13	Gm38082	predicted gene, 38082	30012	0.18
chr6_108091683_108091857	0.13	Setmar	SET domain without mariner transposase fusion	26708	0.18
chr10_84885783_84886161	0.13	Ric8b	RIC8 guanine nucleotide exchange factor B	31644	0.17
chr14_66279141_66279338	0.13	Ptk2b	PTK2 protein tyrosine kinase 2 beta	1743	0.32
chr2_68947159_68947379	0.13	Cers6	ceramide synthase 6	9	0.97
chr6_50037597_50037914	0.13	Gm3455	predicted gene 3455	13431	0.26
chr13_99092586_99092968	0.13	2310020H05Rik	RIKEN cDNA 2310020H05 gene	4856	0.18
chr11_102432106_102432323	0.13	Grn	granulin	571	0.58
chr11_79747289_79747692	0.13	Mir365-2	microRNA 365-2	21090	0.12
chr6_91703317_91703496	0.13	Slc6a6	solute carrier family 6 (neurotransmitter transporter, taurine), member 6	1749	0.25
chr12_72490399_72490568	0.13	Lrrc9	leucine rich repeat containing 9	5184	0.21
chr17_81064683_81064872	0.13	Thumpd2	THUMP domain containing 2	290	0.94
chr6_139852445_139852613	0.13	Pik3c2g	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma	8881	0.22
chr11_58020856_58021032	0.13	Larp1	La ribonucleoprotein domain family, member 1	11880	0.15
chr8_111737464_111737633	0.13	Bcar1	breast cancer anti-estrogen resistance 1	5412	0.2
chr16_23609739_23610190	0.12	Rtp4	receptor transporter protein 4	39	0.98
chr9_20868532_20868915	0.12	Shfl	shiftless antiviral inhibitor of ribosomal frameshifting	43	0.94
chr8_121083645_121083858	0.12	Foxf1	forkhead box F1	635	0.34
chr1_92179149_92179712	0.12	Hdac4	histone deacetylase 4	867	0.7
chr12_69790259_69790597	0.12	4930512B01Rik	RIKEN cDNA 4930512B01 gene	73	0.76
chr12_82265513_82265664	0.12	Sipa1l1	signal-induced proliferation-associated 1 like 1	9003	0.27
chr13_67683658_67684247	0.12	Zfp738	zinc finger protein 738	401	0.71
chr13_75225448_75225621	0.12	Gm19095	predicted gene, 19095	26320	0.24
chr5_89341929_89342080	0.12	Gc	vitamin D binding protein	93624	0.09
chr6_97310793_97311248	0.12	Frmd4b	FERM domain containing 4B	1360	0.49
chr2_146429524_146429960	0.12	Ralgapa2	Ral GTPase activating protein, alpha subunit 2 (catalytic)	16866	0.26
chr5_115565672_115565823	0.12	Gcn1	GCN1 activator of EIF2AK4	444	0.69
chr5_44244398_44244549	0.12	Tapt1	transmembrane anterior posterior transformation 1	17847	0.11
chr2_94010991_94011165	0.12	Alkbh3	alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase	271	0.89
chrX_49624123_49624288	0.12	Gm14719	predicted gene 14719	36755	0.15
chr14_21357195_21357346	0.12	Adk	adenosine kinase	11800	0.25
chr4_53826592_53826930	0.12	Tmem38b	transmembrane protein 38B	704	0.65
chr11_22871923_22872271	0.11	Gm24917	predicted gene, 24917	3196	0.16
chr7_114778861_114779234	0.11	Insc	INSC spindle orientation adaptor protein	7726	0.19
chrX_38218134_38218423	0.11	Mir3110	microRNA 3110	7837	0.15
chr18_39486774_39486949	0.11	Nr3c1	nuclear receptor subfamily 3, group C, member 1	371	0.91
chr1_67192772_67192960	0.11	Gm15668	predicted gene 15668	56334	0.12
chr13_40971914_40972082	0.11	Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	18583	0.1
chr6_121302024_121302175	0.11	Slc6a13	solute carrier family 6 (neurotransmitter transporter, GABA), member 13	1317	0.36
chr11_109705848_109706019	0.11	Fam20a	family with sequence similarity 20, member A	16323	0.17
chr19_14596433_14596591	0.11	Tle4	transducin-like enhancer of split 4	973	0.68
chr18_58659158_58659487	0.11	Isoc1	isochorismatase domain containing 1	144	0.97
chr13_29985974_29986454	0.11	E2f3	E2F transcription factor 3	151	0.96
chr13_94398571_94398749	0.11	Ap3b1	adaptor-related protein complex 3, beta 1 subunit	39700	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf5_Irf6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.1	0.4	GO:0019276	UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1	0.2	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1	0.2	GO:0070346	positive regulation of fat cell proliferation(GO:0070346)
0.1	0.2	GO:0061341	non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1	0.2	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.1	0.2	GO:0097167	circadian regulation of translation(GO:0097167)
0.1	0.2	GO:1902896	terminal web assembly(GO:1902896)
0.1	0.2	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.0	0.2	GO:0009414	response to water deprivation(GO:0009414)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.1	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.1	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.0	0.2	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.2	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.0	0.1	GO:0071332	cellular response to fructose stimulus(GO:0071332)
0.0	0.1	GO:0032439	endosome localization(GO:0032439)
0.0	0.1	GO:0071492	cellular response to UV-A(GO:0071492)
0.0	0.1	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.0	0.1	GO:0003278	apoptotic process involved in heart morphogenesis(GO:0003278)
0.0	0.2	GO:0044351	macropinocytosis(GO:0044351)
0.0	0.1	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.1	GO:0035553	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0	0.3	GO:0048242	epinephrine secretion(GO:0048242)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0000430	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0	0.1	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.2	GO:0051771	negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0	0.1	GO:0042045	epithelial fluid transport(GO:0042045)
0.0	0.1	GO:0048369	lateral mesoderm morphogenesis(GO:0048369) lateral mesoderm formation(GO:0048370) lateral mesodermal cell differentiation(GO:0048371)
0.0	0.1	GO:0030050	vesicle transport along actin filament(GO:0030050)
0.0	0.3	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.2	GO:0010944	negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0	0.1	GO:0070668	mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.0	0.1	GO:0010961	cellular magnesium ion homeostasis(GO:0010961)
0.0	0.1	GO:1903011	negative regulation of bone development(GO:1903011)
0.0	0.1	GO:0048388	endosomal lumen acidification(GO:0048388)
0.0	0.3	GO:0046548	retinal rod cell development(GO:0046548)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.1	GO:0052055	modulation by symbiont of host molecular function(GO:0052055)
0.0	0.1	GO:2000074	regulation of type B pancreatic cell development(GO:2000074)
0.0	0.1	GO:0032289	central nervous system myelin formation(GO:0032289)
0.0	0.1	GO:0002756	MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.2	GO:0014842	regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.0	0.1	GO:0014870	response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0	0.1	GO:0070344	fat cell proliferation(GO:0070341) regulation of fat cell proliferation(GO:0070344) negative regulation of fat cell proliferation(GO:0070345)
0.0	0.1	GO:0072674	multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0	0.1	GO:2001181	positive regulation of interleukin-10 secretion(GO:2001181)
0.0	0.1	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.1	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.0	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.0	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.0	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.1	GO:0034239	regulation of macrophage fusion(GO:0034239)
0.0	0.0	GO:0090191	negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.0	0.0	GO:1903894	regulation of IRE1-mediated unfolded protein response(GO:1903894)
0.0	0.1	GO:1901727	positive regulation of histone deacetylase activity(GO:1901727)
0.0	0.1	GO:0071225	cellular response to muramyl dipeptide(GO:0071225)
0.0	0.0	GO:0035523	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.1	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.1	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.1	GO:0006744	ubiquinone biosynthetic process(GO:0006744)
0.0	0.0	GO:0014022	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.0	GO:0032484	Ral protein signal transduction(GO:0032484)
0.0	0.0	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.0	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.1	GO:0021796	cerebral cortex regionalization(GO:0021796)
0.0	0.1	GO:1904262	negative regulation of TORC1 signaling(GO:1904262)
0.0	0.1	GO:0018344	protein geranylgeranylation(GO:0018344)
0.0	0.1	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
0.0	0.0	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.0	GO:0038171	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.0	GO:0051562	negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0	0.0	GO:0060762	regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0	0.0	GO:0071873	response to norepinephrine(GO:0071873)
0.0	0.1	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.3	GO:0032467	positive regulation of cytokinesis(GO:0032467)
0.0	0.1	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.1	GO:0051044	positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0	0.1	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0	0.2	GO:0009303	rRNA transcription(GO:0009303)
0.0	0.0	GO:0035754	B cell chemotaxis(GO:0035754)
0.0	0.0	GO:0002669	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0044393	microspike(GO:0044393)
0.1	0.2	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.1	GO:0044354	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.2	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	0.2	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0030478	actin cap(GO:0030478)
0.0	0.1	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.0	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.0	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.1	GO:0000445	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.0	GO:1990761	growth cone lamellipodium(GO:1990761)
0.0	0.2	GO:0000930	gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.1	0.2	GO:0070644	vitamin D response element binding(GO:0070644)
0.1	0.3	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.1	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.0	0.2	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.0	0.1	GO:0046404	ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0	0.2	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.1	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0005128	erythropoietin receptor binding(GO:0005128)
0.0	0.1	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.2	GO:0019534	toxin transporter activity(GO:0019534)
0.0	0.1	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0	0.3	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.1	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	0.1	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.0	GO:0031893	vasopressin receptor binding(GO:0031893)
0.0	0.1	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	0.0	GO:0030284	estrogen receptor activity(GO:0030284)
0.0	0.3	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.2	GO:0042301	phosphate ion binding(GO:0042301)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.0	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.2	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.0	GO:0034928	mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.0	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.0	GO:0098821	BMP receptor activity(GO:0098821)
0.0	0.1	GO:0050700	CARD domain binding(GO:0050700)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.0	ST DIFFERENTIATION PATHWAY IN PC12 CELLS	Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.2	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.2	PID IL5 PATHWAY	IL5-mediated signaling events
0.3	ST GAQ PATHWAY	G alpha q Pathway
0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.2	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.3	REACTOME RECYCLING PATHWAY OF L1	Genes involved in Recycling pathway of L1
0.0	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.2	REACTOME SIGNALING BY FGFR1 FUSION MUTANTS	Genes involved in Signaling by FGFR1 fusion mutants