Project
ENCSR904DTN: DNase-seq of mouse liver in constant darkness
Navigation
Downloads
Logo

Results for Irf5_Irf6

Z-value: 0.93

Motif logo

logo of logo of

Transcription factors associated with Irf5_Irf6

Gene Symbol Gene ID Gene Info
Irf5
ENSMUSG00000029771.6 interferon regulatory factor 5
Irf6
ENSMUSG00000026638.9 interferon regulatory factor 6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE Gene Distance Association probability Pearson corr. coef. P-value Plot
chr6_29523942_29524117Irf525960.161909-0.953.8e-03Click!
chr6_29538799_29539193Irf521500.196327-0.891.8e-02Click!
chr6_29522778_29522945Irf537640.131636-0.767.8e-02Click!
chr6_29522974_29523209Irf535340.135510-0.749.1e-02Click!
chr6_29526985_29527412Irf54900.6809480.701.2e-01Click!
chr1_193170032_193170189Irf616070.218081-0.901.5e-02Click!
chr1_193153538_193153923Irf65760.6329240.891.7e-02Click!
chr1_193169761_193169948Irf613510.2541040.651.6e-01Click!
chr1_193153972_193154171Irf69170.4383030.602.1e-01Click!
chr1_193159245_193159427Irf626670.165053-0.542.7e-01Click!

Activity of the Irf5_Irf6 motif across conditions

Conditions sorted by the z-value of the Irf5_Irf6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_6206187_6206411 0.75 Slc25a13
 solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13
 10819
 0.23
chr6_88641424_88641714 0.69 Kbtbd12
 kelch repeat and BTB (POZ) domain containing 12
 3619
 0.23
chr19_46645853_46646011 0.62 Gm36602
 predicted gene, 36602
 20194
 0.11
chr9_65675680_65676009 0.56 Oaz2
 ornithine decarboxylase antizyme 2
 704
 0.64
chr13_31808871_31809301 0.55 Foxc1
 forkhead box C1
 2453
 0.26
chr6_134538835_134539031 0.54 Lrp6
 low density lipoprotein receptor-related protein 6
 2781
 0.28
chr13_101811863_101812015 0.53 Gm19108
 predicted gene, 19108
 30367
 0.15
chr9_56929068_56929260 0.48 Snx33
 sorting nexin 33
 793
 0.44
chr13_13994363_13994818 0.45 B3galnt2
 UDP-GalNAc:betaGlcNAc beta 1,3-galactosaminyltransferase, polypeptide 2
 170
 0.92
chr2_147961290_147961525 0.44 9030622O22Rik
 RIKEN cDNA 9030622O22 gene
 14778
 0.22
chr11_101070404_101070591 0.44 Naglu
 alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
 485
 0.62
chr9_14381410_14381579 0.44 Endod1
 endonuclease domain containing 1
 13
 0.96
chr1_138617784_138617983 0.42 Nek7
 NIMA (never in mitosis gene a)-related expressed kinase 7
 1791
 0.35
chr9_9230047_9230379 0.42 Gm16833
 predicted gene, 16833
 6075
 0.24
chr11_88614641_88614847 0.40 Msi2
 musashi RNA-binding protein 2
 24597
 0.21
chr1_130761129_130761587 0.39 Gm28856
 predicted gene 28856
 5026
 0.11
chr2_128377797_128377975 0.39 Morrbid
 myeloid RNA regulator of BCL2L11 induced cell death
 25079
 0.18
chr6_108506487_108506825 0.39 Itpr1
 inositol 1,4,5-trisphosphate receptor 1
 1657
 0.32
chr1_10039266_10039475 0.37 Cspp1
 centrosome and spindle pole associated protein 1
 397
 0.7
chr11_119109577_119109728 0.37 Gm11754
 predicted gene 11754
 1773
 0.27
chr1_84051880_84052058 0.37 Pid1
 phosphotyrosine interaction domain containing 1
 1284
 0.56
chr14_46277334_46277485 0.35 Gm15217
 predicted gene 15217
 102005
 0.06
chr9_111138334_111138716 0.32 Lrrfip2
 leucine rich repeat (in FLII) interacting protein 2
 18850
 0.15
chr16_24061978_24062260 0.32 Gm46545
 predicted gene, 46545
 20571
 0.15
chr4_59546423_59546594 0.32 Ptbp3
 polypyrimidine tract binding protein 3
 2229
 0.23
chr8_23207373_23207572 0.31 Gpat4
 glycerol-3-phosphate acyltransferase 4
 873
 0.36
chr13_119966643_119967735 0.31 Gm20784
 predicted gene, 20784
 4945
 0.11
chr16_6901477_6901805 0.31 Rbfox1
 RNA binding protein, fox-1 homolog (C. elegans) 1
 92419
 0.1
chr13_51101532_51101693 0.30 Spin1
 spindlin 1
 732
 0.73
chr5_125189474_125189632 0.30 Ncor2
 nuclear receptor co-repressor 2
 10334
 0.21
chr13_60508473_60508632 0.30 A530001N23Rik
 RIKEN cDNA A530001N23 gene
 19744
 0.15
chr19_47311513_47311735 0.29 Sh3pxd2a
 SH3 and PX domains 2A
 3127
 0.23
chr19_29367023_29367182 0.29 Plgrkt
 plasminogen receptor, C-terminal lysine transmembrane protein
 206
 0.65
chr4_123645434_123645623 0.28 Gm12926
 predicted gene 12926
 15233
 0.13
chr1_105356184_105356368 0.28 Gm17634
 predicted gene, 17634
 269
 0.62
chr4_59452546_59452697 0.28 Susd1
 sushi domain containing 1
 13988
 0.19
chr19_5529673_5529945 0.28 Gm31166
 predicted gene, 31166
 1821
 0.14
chr2_38225178_38225332 0.27 Gm44455
 predicted gene, 44455
 133
 0.96
chr14_64154802_64154953 0.26 9630015K15Rik
 RIKEN cDNA 9630015K15 gene
 38563
 0.11
chr10_111490434_111490604 0.26 Nap1l1
 nucleosome assembly protein 1-like 1
 326
 0.84
chr5_130204701_130204852 0.26 Rabgef1
 RAB guanine nucleotide exchange factor (GEF) 1
 2277
 0.16
chr5_129715571_129715984 0.25 Mrps17
 mitochondrial ribosomal protein S17
 80
 0.95
chr10_7589267_7589435 0.25 Lrp11
 low density lipoprotein receptor-related protein 11
 449
 0.78
chr9_27106238_27106393 0.25 Gm48796
 predicted gene, 48796
 7764
 0.17
chr19_46140028_46140457 0.25 Pitx3
 paired-like homeodomain transcription factor 3
 741
 0.53
chr4_15066667_15066833 0.25 Gm11844
 predicted gene 11844
 44168
 0.16
chr18_44661527_44661720 0.25 A930012L18Rik
 RIKEN cDNA A930012L18 gene
 42
 0.93
chr4_102583077_102583228 0.24 Pde4b
 phosphodiesterase 4B, cAMP specific
 4406
 0.34
chr5_99978647_99978803 0.24 Hnrnpd
 heterogeneous nuclear ribonucleoprotein D
 101
 0.78
chr16_17838275_17838426 0.24 Car15
 carbonic anhydrase 15
 14
 0.95
chr5_99269909_99270098 0.24 Gm35394
 predicted gene, 35394
 4092
 0.27
chr15_74967628_74968021 0.24 Ly6e
 lymphocyte antigen 6 complex, locus E
 11269
 0.08
chr13_119966017_119966201 0.23 Gm20784
 predicted gene, 20784
 3865
 0.12
chr5_87573106_87573296 0.23 Sult1d1
 sulfotransferase family 1D, member 1
 4174
 0.13
chr8_61927981_61928360 0.23 Ddx60
 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60
 81
 0.58
chr6_13870954_13871322 0.22 2610001J05Rik
 RIKEN cDNA 2610001J05 gene
 327
 0.54
chr10_20150520_20150679 0.22 Map7
 microtubule-associated protein 7
 1601
 0.37
chr9_55541381_55541949 0.22 Isl2
 insulin related protein 2 (islet 2)
 458
 0.61
chr7_13005790_13006506 0.22 Zbtb45
 zinc finger and BTB domain containing 45
 3652
 0.09
chr3_121531769_121531936 0.22 A530020G20Rik
 RIKEN cDNA A530020G20 gene
 173
 0.82
chr7_30955354_30955627 0.22 Usf2
 upstream transcription factor 2
 40
 0.79
chr3_131552705_131552871 0.22 Papss1
 3'-phosphoadenosine 5'-phosphosulfate synthase 1
 11980
 0.23
chr19_16029303_16029488 0.22 Rpl37-ps1
 ribosomal protein 37, pseudogene 1
 3944
 0.23
chr10_20170266_20170434 0.22 Map7
 microtubule-associated protein 7
 430
 0.82
chr14_11699956_11700511 0.22 Gm48602
 predicted gene, 48602
 67710
 0.12
chr8_111299402_111299697 0.21 Rfwd3
 ring finger and WD repeat domain 3
 642
 0.64
chr14_62557485_62557724 0.21 Fam124a
 family with sequence similarity 124, member A
 1829
 0.24
chr10_127355157_127355314 0.21 Inhbe
 inhibin beta-E
 824
 0.38
chr11_58100366_58100593 0.21 Gm12247
 predicted gene 12247
 2706
 0.16
chr4_115057217_115057403 0.21 Tal1
 T cell acute lymphocytic leukemia 1
 128
 0.95
chr17_6782237_6782457 0.21 Ezr
 ezrin
 437
 0.8
chr1_131620226_131620377 0.21 Gm8532
 predicted gene 8532
 12668
 0.14
chr7_139401907_139402067 0.21 Inpp5a
 inositol polyphosphate-5-phosphatase A
 1498
 0.49
chr13_8651016_8651177 0.20 Gm48262
 predicted gene, 48262
 98076
 0.06
chr4_33033624_33033916 0.20 Ube2j1
 ubiquitin-conjugating enzyme E2J 1
 2242
 0.18
chr12_100158931_100159295 0.20 Nrde2
 nrde-2 necessary for RNA interference, domain containing
 535
 0.7
chr13_60479839_60480430 0.20 Gm48500
 predicted gene, 48500
 1164
 0.45
chr16_96363004_96363159 0.20 Igsf5
 immunoglobulin superfamily, member 5
 1287
 0.33
chr15_98869205_98869356 0.20 Kmt2d
 lysine (K)-specific methyltransferase 2D
 1903
 0.14
chr11_43767190_43767354 0.20 Ttc1
 tetratricopeptide repeat domain 1
 19264
 0.19
chr2_27725053_27725318 0.20 Rxra
 retinoid X receptor alpha
 34
 0.99
chr15_74955213_74955440 0.20 Ly6e
 lymphocyte antigen 6 complex, locus E
 66
 0.93
chr3_145912337_145912507 0.20 Bcl10
 B cell leukemia/lymphoma 10
 10382
 0.17
chr6_116240202_116240376 0.20 Washc2
 WASH complex subunit 2`
 14317
 0.11
chr10_75187490_75187671 0.19 Bcr
 BCR activator of RhoGEF and GTPase
 11204
 0.2
chr16_91043514_91043963 0.19 Paxbp1
 PAX3 and PAX7 binding protein 1
 426
 0.63
chr5_145871647_145871798 0.19 Cyp3a11
 cytochrome P450, family 3, subfamily a, polypeptide 11
 4969
 0.18
chr3_27183172_27183371 0.19 Nceh1
 neutral cholesterol ester hydrolase 1
 267
 0.91
chr8_35826443_35826604 0.19 Cldn23
 claudin 23
 36
 0.97
chr18_75370151_75370534 0.19 Smad7
 SMAD family member 7
 366
 0.87
chr11_69080646_69080973 0.19 Gm25371
 predicted gene, 25371
 5794
 0.07
chr14_63247987_63248412 0.19 Gata4
 GATA binding protein 4
 2928
 0.24
chr17_71485826_71486209 0.19 Gm18738
 predicted gene, 18738
 2625
 0.16
chr5_72410672_72410832 0.18 Gm19560
 predicted gene, 19560
 1308
 0.39
chr13_59556477_59556954 0.18 Agtpbp1
 ATP/GTP binding protein 1
 204
 0.85
chr15_60823871_60824050 0.18 9930014A18Rik
 RIKEN cDNA 9930014A18 gene
 381
 0.77
chr2_91084552_91084841 0.18 Spi1
 spleen focus forming virus (SFFV) proviral integration oncogene
 2288
 0.17
chr2_93470457_93470622 0.18 Gm10804
 predicted gene 10804
 2100
 0.3
chr4_98322017_98322210 0.18 0610025J13Rik
 RIKEN cDNA 0610025J13 gene
 665
 0.68
chr10_12996840_12997182 0.18 Sf3b5
 splicing factor 3b, subunit 5
 8332
 0.19
chr16_8736038_8736588 0.18 Usp7
 ubiquitin specific peptidase 7
 2029
 0.28
chr15_65787239_65787398 0.18 Efr3a
 EFR3 homolog A
 270
 0.94
chr19_25383146_25383377 0.18 Kank1
 KN motif and ankyrin repeat domains 1
 12042
 0.21
chr6_126848563_126848769 0.17 Ndufa9
 NADH:ubiquinone oxidoreductase subunit A9
 459
 0.74
chr18_26015437_26015603 0.17 Gm33228
 predicted gene, 33228
 3217
 0.39
chr16_52081908_52082365 0.17 Gm23513
 predicted gene, 23513
 23011
 0.21
chr2_31501565_31501761 0.17 Ass1
 argininosuccinate synthetase 1
 937
 0.56
chr9_21031078_21031624 0.17 Icam5
 intercellular adhesion molecule 5, telencephalin
 722
 0.27
chr10_9901181_9901520 0.17 Gm46210
 predicted gene, 46210
 37
 0.79
chr6_3620652_3620816 0.17 Vps50
 VPS50 EARP/GARPII complex subunit
 26716
 0.17
chr13_38122267_38122440 0.17 Dsp
 desmoplakin
 28941
 0.13
chr3_85273227_85273668 0.16 1700036G14Rik
 RIKEN cDNA 1700036G14 gene
 44072
 0.16
chr7_16738552_16738717 0.16 Ap2s1
 adaptor-related protein complex 2, sigma 1 subunit
 96
 0.94
chr18_46280937_46281101 0.16 Pggt1b
 protein geranylgeranyltransferase type I, beta subunit
 26
 0.97
chr4_101448515_101448685 0.16 Ak4
 adenylate kinase 4
 1377
 0.4
chr3_60965282_60965682 0.16 P2ry1
 purinergic receptor P2Y, G-protein coupled 1
 37313
 0.16
chr5_32469434_32469600 0.16 Gm43313
 predicted gene 43313
 2322
 0.19
chr3_108114477_108114651 0.16 Gnat2
 guanine nucleotide binding protein, alpha transducing 2
 17321
 0.08
chr8_85555887_85556054 0.15 Dnaja2
 DnaJ heat shock protein family (Hsp40) member A2
 626
 0.69
chr8_12720450_12720739 0.15 Gm15348
 predicted gene 15348
 1467
 0.36
chr3_28026863_28027216 0.15 Pld1
 phospholipase D1
 4223
 0.33
chr11_5520050_5520258 0.15 Xbp1
 X-box binding protein 1
 505
 0.71
chr12_55490259_55490936 0.15 Nfkbia
 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
 1213
 0.45
chr6_134543337_134543527 0.15 Lrp6
 low density lipoprotein receptor-related protein 6
 1718
 0.37
chr11_49064151_49064330 0.15 Tgtp2
 T cell specific GTPase 2
 34
 0.95
chr1_151501177_151501494 0.15 Rnf2
 ring finger protein 2
 380
 0.75
chr8_48733650_48734100 0.15 Tenm3
 teneurin transmembrane protein 3
 59185
 0.14
chr10_75415055_75415209 0.15 Upb1
 ureidopropionase, beta
 5089
 0.19
chr1_37890066_37890236 0.14 Mitd1
 MIT, microtubule interacting and transport, domain containing 1
 125
 0.73
chr4_135269728_135270123 0.14 Clic4
 chloride intracellular channel 4 (mitochondrial)
 2889
 0.19
chr8_93333775_93334133 0.14 Ces1g
 carboxylesterase 1G
 3354
 0.19
chr1_134962882_134963043 0.14 Ube2t
 ubiquitin-conjugating enzyme E2T
 344
 0.87
chr6_122819451_122819712 0.14 Foxj2
 forkhead box J2
 333
 0.71
chr18_64338075_64338233 0.14 Onecut2
 one cut domain, family member 2
 1866
 0.3
chr9_65193311_65193501 0.14 Parp16
 poly (ADP-ribose) polymerase family, member 16
 1947
 0.21
chr7_39841847_39842021 0.14 4930558N11Rik
 RIKEN cDNA 4930558N11 gene
 44192
 0.11
chr9_42262292_42262705 0.14 Sc5d
 sterol-C5-desaturase
 1702
 0.34
chr8_110629373_110629540 0.14 Vac14
 Vac14 homolog (S. cerevisiae)
 10844
 0.21
chr3_122274519_122274867 0.14 Dnttip2
 deoxynucleotidyltransferase, terminal, interacting protein 2
 275
 0.82
chr2_72286436_72286609 0.14 Map3k20
 mitogen-activated protein kinase kinase kinase 20
 728
 0.67
chr7_110894004_110894327 0.14 Gm16336
 predicted gene 16336
 10820
 0.16
chr9_8043039_8043256 0.14 Cfap300
 cilia and flagella associated protein 300
 324
 0.88
chr16_22259188_22259423 0.14 Tra2b
 transformer 2 beta
 317
 0.83
chr3_65527969_65528149 0.14 4931440P22Rik
 RIKEN cDNA 4931440P22 gene
 125
 0.75
chr4_150371202_150371353 0.14 Rere
 arginine glutamic acid dipeptide (RE) repeats
 35117
 0.15
chr16_93816432_93816740 0.14 Dop1b
 DOP1 leucine zipper like protein B
 7152
 0.14
chr7_92681661_92681812 0.14 Pcf11
 PCF11 cleavage and polyadenylation factor subunit
 11802
 0.12
chr13_120096376_120096558 0.14 Gm21378
 predicted gene, 21378
 3865
 0.15
chr5_100636918_100637077 0.14 Coq2
 coenzyme Q2 4-hydroxybenzoate polyprenyltransferase
 27422
 0.12
chr7_97736977_97737173 0.14 Aqp11
 aquaporin 11
 863
 0.54
chr1_51774175_51774474 0.13 Myo1b
 myosin IB
 2112
 0.33
chr11_72690308_72690642 0.13 Ankfy1
 ankyrin repeat and FYVE domain containing 1
 469
 0.8
chr4_56222157_56222524 0.13 2310081O03Rik
 RIKEN cDNA 2310081O03 gene
 2181
 0.42
chr3_108022402_108022739 0.13 Gm12498
 predicted gene 12498
 2679
 0.1
chr15_58415328_58415520 0.13 Fam91a1
 family with sequence similarity 91, member A1
 44
 0.97
chr16_26505107_26505285 0.13 Tmem207
 transmembrane protein 207
 21566
 0.21
chr5_136506363_136506567 0.13 Gm38082
 predicted gene, 38082
 30012
 0.18
chr6_108091683_108091857 0.13 Setmar
 SET domain without mariner transposase fusion
 26708
 0.18
chr10_84885783_84886161 0.13 Ric8b
 RIC8 guanine nucleotide exchange factor B
 31644
 0.17
chr14_66279141_66279338 0.13 Ptk2b
 PTK2 protein tyrosine kinase 2 beta
 1743
 0.32
chr2_68947159_68947379 0.13 Cers6
 ceramide synthase 6
 9
 0.97
chr6_50037597_50037914 0.13 Gm3455
 predicted gene 3455
 13431
 0.26
chr13_99092586_99092968 0.13 2310020H05Rik
 RIKEN cDNA 2310020H05 gene
 4856
 0.18
chr11_102432106_102432323 0.13 Grn
 granulin
 571
 0.58
chr11_79747289_79747692 0.13 Mir365-2
 microRNA 365-2
 21090
 0.12
chr6_91703317_91703496 0.13 Slc6a6
 solute carrier family 6 (neurotransmitter transporter, taurine), member 6
 1749
 0.25
chr12_72490399_72490568 0.13 Lrrc9
 leucine rich repeat containing 9
 5184
 0.21
chr17_81064683_81064872 0.13 Thumpd2
 THUMP domain containing 2
 290
 0.94
chr6_139852445_139852613 0.13 Pik3c2g
 phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma
 8881
 0.22
chr11_58020856_58021032 0.13 Larp1
 La ribonucleoprotein domain family, member 1
 11880
 0.15
chr8_111737464_111737633 0.13 Bcar1
 breast cancer anti-estrogen resistance 1
 5412
 0.2
chr16_23609739_23610190 0.12 Rtp4
 receptor transporter protein 4
 39
 0.98
chr9_20868532_20868915 0.12 Shfl
 shiftless antiviral inhibitor of ribosomal frameshifting
 43
 0.94
chr8_121083645_121083858 0.12 Foxf1
 forkhead box F1
 635
 0.34
chr1_92179149_92179712 0.12 Hdac4
 histone deacetylase 4
 867
 0.7
chr12_69790259_69790597 0.12 4930512B01Rik
 RIKEN cDNA 4930512B01 gene
 73
 0.76
chr12_82265513_82265664 0.12 Sipa1l1
 signal-induced proliferation-associated 1 like 1
 9003
 0.27
chr13_67683658_67684247 0.12 Zfp738
 zinc finger protein 738
 401
 0.71
chr13_75225448_75225621 0.12 Gm19095
 predicted gene, 19095
 26320
 0.24
chr5_89341929_89342080 0.12 Gc
 vitamin D binding protein
 93624
 0.09
chr6_97310793_97311248 0.12 Frmd4b
 FERM domain containing 4B
 1360
 0.49
chr2_146429524_146429960 0.12 Ralgapa2
 Ral GTPase activating protein, alpha subunit 2 (catalytic)
 16866
 0.26
chr5_115565672_115565823 0.12 Gcn1
 GCN1 activator of EIF2AK4
 444
 0.69
chr5_44244398_44244549 0.12 Tapt1
 transmembrane anterior posterior transformation 1
 17847
 0.11
chr2_94010991_94011165 0.12 Alkbh3
 alkB homolog 3, alpha-ketoglutarate-dependent dioxygenase
 271
 0.89
chrX_49624123_49624288 0.12 Gm14719
 predicted gene 14719
 36755
 0.15
chr14_21357195_21357346 0.12 Adk
 adenosine kinase
 11800
 0.25
chr4_53826592_53826930 0.12 Tmem38b
 transmembrane protein 38B
 704
 0.65
chr11_22871923_22872271 0.11 Gm24917
 predicted gene, 24917
 3196
 0.16
chr7_114778861_114779234 0.11 Insc
 INSC spindle orientation adaptor protein
 7726
 0.19
chrX_38218134_38218423 0.11 Mir3110
 microRNA 3110
 7837
 0.15
chr18_39486774_39486949 0.11 Nr3c1
 nuclear receptor subfamily 3, group C, member 1
 371
 0.91
chr1_67192772_67192960 0.11 Gm15668
 predicted gene 15668
 56334
 0.12
chr13_40971914_40972082 0.11 Gcnt2
 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
 18583
 0.1
chr6_121302024_121302175 0.11 Slc6a13
 solute carrier family 6 (neurotransmitter transporter, GABA), member 13
 1317
 0.36
chr11_109705848_109706019 0.11 Fam20a
 family with sequence similarity 20, member A
 16323
 0.17
chr19_14596433_14596591 0.11 Tle4
 transducin-like enhancer of split 4
 973
 0.68
chr18_58659158_58659487 0.11 Isoc1
 isochorismatase domain containing 1
 144
 0.97
chr13_29985974_29986454 0.11 E2f3
 E2F transcription factor 3
 151
 0.96
chr13_94398571_94398749 0.11 Ap3b1
 adaptor-related protein complex 3, beta 1 subunit
 39700
 0.13

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Irf5_Irf6

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.
View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
0.1 0.4 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.1 0.2 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1 0.2 GO:0070346 positive regulation of fat cell proliferation(GO:0070346)
0.1 0.2 GO:0061341 non-canonical Wnt signaling pathway involved in heart development(GO:0061341) planar cell polarity pathway involved in heart morphogenesis(GO:0061346)
0.1 0.2 GO:0060375 regulation of mast cell differentiation(GO:0060375)
0.1 0.2 GO:0097167 circadian regulation of translation(GO:0097167)
0.1 0.2 GO:1902896 terminal web assembly(GO:1902896)
0.1 0.2 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.0 0.2 GO:0009414 response to water deprivation(GO:0009414)
0.0 0.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0 0.1 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.1 GO:0021524 visceral motor neuron differentiation(GO:0021524)
0.0 0.2 GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0 0.2 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
0.0 0.1 GO:0071332 cellular response to fructose stimulus(GO:0071332)
0.0 0.1 GO:0032439 endosome localization(GO:0032439)
0.0 0.1 GO:0071492 cellular response to UV-A(GO:0071492)
0.0 0.1 GO:0002071 glandular epithelial cell maturation(GO:0002071)
0.0 0.1 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
0.0 0.2 GO:0044351 macropinocytosis(GO:0044351)
0.0 0.1 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.3 GO:0048242 epinephrine secretion(GO:0048242)
0.0 0.1 GO:1901078 negative regulation of relaxation of muscle(GO:1901078)
0.0 0.1 GO:0000430 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.1 GO:0035519 protein K29-linked ubiquitination(GO:0035519)
0.0 0.1 GO:0010046 response to mycotoxin(GO:0010046)
0.0 0.2 GO:0051771 negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771)
0.0 0.1 GO:0042045 epithelial fluid transport(GO:0042045)
0.0 0.1 GO:0048369 lateral mesoderm morphogenesis(GO:0048369) lateral mesoderm formation(GO:0048370) lateral mesodermal cell differentiation(GO:0048371)
0.0 0.1 GO:0030050 vesicle transport along actin filament(GO:0030050)
0.0 0.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.2 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.0 0.1 GO:0070668 mast cell proliferation(GO:0070662) regulation of mast cell proliferation(GO:0070666) positive regulation of mast cell proliferation(GO:0070668)
0.0 0.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.1 GO:1903011 negative regulation of bone development(GO:1903011)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.3 GO:0046548 retinal rod cell development(GO:0046548)
0.0 0.1 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0 0.1 GO:1902564 negative regulation of neutrophil activation(GO:1902564)
0.0 0.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0052055 modulation by symbiont of host molecular function(GO:0052055)
0.0 0.1 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
0.0 0.1 GO:0032289 central nervous system myelin formation(GO:0032289)
0.0 0.1 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 0.1 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 0.2 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.0 0.1 GO:0014870 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0070344 fat cell proliferation(GO:0070341) regulation of fat cell proliferation(GO:0070344) negative regulation of fat cell proliferation(GO:0070345)
0.0 0.1 GO:0072674 multinuclear osteoclast differentiation(GO:0072674) osteoclast fusion(GO:0072675)
0.0 0.1 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
0.0 0.1 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.1 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0 0.0 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0 0.1 GO:0042769 DNA damage response, detection of DNA damage(GO:0042769)
0.0 0.0 GO:0050427 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0 0.0 GO:0002125 maternal aggressive behavior(GO:0002125)
0.0 0.1 GO:0034239 regulation of macrophage fusion(GO:0034239)
0.0 0.0 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
0.0 0.0 GO:1903894 regulation of IRE1-mediated unfolded protein response(GO:1903894)
0.0 0.1 GO:1901727 positive regulation of histone deacetylase activity(GO:1901727)
0.0 0.1 GO:0071225 cellular response to muramyl dipeptide(GO:0071225)
0.0 0.0 GO:0035523 protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0 0.1 GO:1903799 negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0 0.1 GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0 0.0 GO:0006562 proline catabolic process(GO:0006562)
0.0 0.1 GO:0006744 ubiquinone biosynthetic process(GO:0006744)
0.0 0.0 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.0 GO:0032484 Ral protein signal transduction(GO:0032484)
0.0 0.0 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.0 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0 0.1 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.0 0.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.0 GO:0038171 cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0 0.0 GO:0051562 negative regulation of mitochondrial calcium ion concentration(GO:0051562)
0.0 0.0 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
0.0 0.0 GO:0071873 response to norepinephrine(GO:0071873)
0.0 0.1 GO:0033211 adiponectin-activated signaling pathway(GO:0033211)
0.0 0.3 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.1 GO:1900103 positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0 0.1 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 0.1 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0 0.2 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.0 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 0.0 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0044393 microspike(GO:0044393)
0.1 0.2 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0 0.1 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.1 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.0 0.1 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 0.2 GO:0016342 catenin complex(GO:0016342)
0.0 0.1 GO:0030478 actin cap(GO:0030478)
0.0 0.1 GO:0035355 Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0 0.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0 0.1 GO:0001739 sex chromatin(GO:0001739)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.0 GO:0097149 centralspindlin complex(GO:0097149)
0.0 0.1 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0 0.0 GO:1990761 growth cone lamellipodium(GO:1990761)
0.0 0.2 GO:0000930 gamma-tubulin complex(GO:0000930)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.1 0.2 GO:0070644 vitamin D response element binding(GO:0070644)
0.1 0.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.0 0.1 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0 0.2 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.0 0.1 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.0 0.1 GO:0004366 glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.2 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.0 0.1 GO:0046404 ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 0.1 GO:0031849 olfactory receptor binding(GO:0031849)
0.0 0.1 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0005128 erythropoietin receptor binding(GO:0005128)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.1 GO:0043125 ErbB-3 class receptor binding(GO:0043125)
0.0 0.1 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0 0.2 GO:0019534 toxin transporter activity(GO:0019534)
0.0 0.1 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0 0.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.0 0.1 GO:1990239 steroid hormone binding(GO:1990239)
0.0 0.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.0 0.1 GO:0045504 dynein heavy chain binding(GO:0045504)
0.0 0.1 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0 0.1 GO:1990825 sequence-specific mRNA binding(GO:1990825)
0.0 0.1 GO:0047961 glycine N-acyltransferase activity(GO:0047961)
0.0 0.1 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.0 0.0 GO:0031893 vasopressin receptor binding(GO:0031893)
0.0 0.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 0.0 GO:0030284 estrogen receptor activity(GO:0030284)
0.0 0.3 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 0.2 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.0 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.0 GO:0031826 type 2A serotonin receptor binding(GO:0031826)
0.0 0.2 GO:0044548 S100 protein binding(GO:0044548)
0.0 0.0 GO:0043423 3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0 0.1 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0 0.0 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0 0.0 GO:0034928 mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.0 0.1 GO:0071723 lipopeptide binding(GO:0071723)
0.0 0.1 GO:0008301 DNA binding, bending(GO:0008301)
0.0 0.0 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 0.1 GO:0004630 phospholipase D activity(GO:0004630)
0.0 0.0 GO:0098821 BMP receptor activity(GO:0098821)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.2 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 0.2 PID IL5 PATHWAY IL5-mediated signaling events
0.0 0.3 ST GAQ PATHWAY G alpha q Pathway
0.0 0.3 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0 Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)
0.0 0.2 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.0 0.0 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 0.1 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0 0.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.0 0.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.0 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.0 0.2 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants