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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Lhx3

Z-value: 1.65

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Transcription factors associated with Lhx3

Gene Symbol	Gene ID	Gene Info
Lhx3 Ensembl NCBI MGI UniProt	ENSMUSG00000026934.9	LIM homeobox protein 3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_26214445_26214599	Lhx3	6233	0.119378	0.82	4.5e-02	Click!
chr2_26208213_26208385	Lhx3	10	0.953015	-0.38	4.6e-01	Click!
chr2_26214666_26214824	Lhx3	6456	0.118619	-0.09	8.6e-01	Click!
chr2_26208483_26208654	Lhx3	279	0.829873	0.04	9.4e-01	Click!

Activity of the Lhx3 motif across conditions

Conditions sorted by the z-value of the Lhx3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_108612751_108612908	1.97	Syt1	synaptotagmin I	24135	0.23
chr6_35874026_35874908	1.63	Gm43442	predicted gene 43442	52244	0.17
chr7_139559759_139559933	1.57	Nkx6-2	NK6 homeobox 2	22944	0.17
chr8_4335762_4335913	1.35	Ccl25	chemokine (C-C motif) ligand 25	3578	0.14
chr2_14099979_14100130	1.30	Stam	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	25627	0.12
chr10_115337191_115337351	1.21	Tmem19	transmembrane protein 19	11793	0.14
chr11_111605518_111605669	1.16	Gm11676	predicted gene 11676	7713	0.32
chr11_74821059_74821337	1.14	Mnt	max binding protein	9722	0.13
chr12_8643213_8643385	1.14	Pum2	pumilio RNA-binding family member 2	30835	0.16
chr11_70713419_70713657	1.06	Mir6925	microRNA 6925	7548	0.08
chr2_155539663_155540189	1.02	Mipep-ps	mitochondrial intermediate peptidase, pseudogene	2721	0.13
chr18_64325483_64325793	0.98	St8sia3os	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand	8068	0.16
chr15_79690269_79690868	0.98	Gtpbp1	GTP binding protein 1	277	0.78
chr3_94338287_94338715	0.89	Gm43743	predicted gene 43743	3169	0.1
chr15_31279226_31279377	0.89	Gm49296	predicted gene, 49296	2788	0.19
chr5_117293923_117294074	0.89	Gm3786	predicted gene 3786	408	0.73
chr19_44027305_44027461	0.84	Cyp2c23	cytochrome P450, family 2, subfamily c, polypeptide 23	1816	0.28
chr16_27391982_27392165	0.84	Ccdc50	coiled-coil domain containing 50	2105	0.33
chr2_119566293_119566470	0.83	Chp1	calcineurin-like EF hand protein 1	224	0.89
chr1_60862632_60862783	0.83	Gm38137	predicted gene, 38137	17631	0.12
chr4_142088876_142089143	0.80	Tmem51os1	Tmem51 opposite strand 1	4153	0.16
chr15_54947760_54948020	0.79	Gm26684	predicted gene, 26684	4180	0.19
chr15_25942169_25942359	0.77	Retreg1	reticulophagy regulator 1	415	0.85
chr8_128687947_128688299	0.76	Itgb1	integrin beta 1 (fibronectin receptor beta)	2253	0.29
chr18_61398040_61398397	0.75	Mir378a	microRNA 378a	318	0.54
chr4_116720481_116720689	0.75	Tesk2	testis-specific kinase 2	363	0.78
chr19_43767883_43768034	0.75	Cutc	cutC copper transporter	3085	0.18
chr16_24394028_24394581	0.75	Lpp	LIM domain containing preferred translocation partner in lipoma	566	0.73
chr7_72345699_72346292	0.75	Mctp2	multiple C2 domains, transmembrane 2	39387	0.21
chr2_166522580_166522731	0.75	Gm14267	predicted gene 14267	282	0.93
chr3_23937769_23938040	0.73	Naaladl2	N-acetylated alpha-linked acidic dipeptidase-like 2	1573	0.58
chr18_55095856_55096021	0.73	AC163347.1	novel transcript	422	0.83
chr3_80058876_80059038	0.72	A330069K06Rik	RIKEN cDNA A330069K06 gene	4065	0.25
chr9_79213455_79213848	0.72	Gm47499	predicted gene, 47499	11644	0.17
chr4_132129267_132129447	0.71	Oprd1	opioid receptor, delta 1	15129	0.1
chr2_69228328_69228964	0.71	G6pc2	glucose-6-phosphatase, catalytic, 2	8618	0.15
chr6_71236030_71236205	0.69	Smyd1	SET and MYND domain containing 1	19243	0.1
chr4_48315210_48315516	0.69	Gm12435	predicted gene 12435	29867	0.16
chr2_15096629_15097014	0.69	Arl5b	ADP-ribosylation factor-like 5B	21822	0.14
chr1_119253363_119253514	0.69	Gm3508	predicted gene 3508	10685	0.22
chr11_109475236_109475399	0.69	Slc16a6	solute carrier family 16 (monocarboxylic acid transporters), member 6	1719	0.22
chr5_8928809_8928960	0.68	Abcb4	ATP-binding cassette, sub-family B (MDR/TAP), member 4	158	0.94
chr3_93589735_93589907	0.68	S100a10	S100 calcium binding protein A10 (calpactin)	29094	0.09
chr11_78120991_78121457	0.67	Fam222b	family with sequence similarity 222, member B	5618	0.09
chr3_28736802_28736989	0.66	1700112D23Rik	RIKEN cDNA 1700112D23 gene	5345	0.16
chr17_73134412_73134584	0.65	Lclat1	lysocardiolipin acyltransferase 1	8071	0.23
chr10_53348308_53348525	0.65	Cep85l	centrosomal protein 85-like	1407	0.3
chr17_87445917_87446172	0.65	Calm2	calmodulin 2	804	0.49
chr4_97099326_97100044	0.64	Gm27521	predicted gene, 27521	182665	0.03
chr2_6611640_6611812	0.64	Celf2	CUGBP, Elav-like family member 2	4454	0.32
chr13_25083444_25083634	0.64	Dcdc2a	doublecortin domain containing 2a	12808	0.18
chr17_29381584_29381926	0.63	Fgd2	FYVE, RhoGEF and PH domain containing 2	5254	0.14
chr12_33302809_33302960	0.63	Atxn7l1	ataxin 7-like 1	369	0.89
chr9_66414274_66414486	0.63	Gm28379	predicted gene 28379	6261	0.21
chr9_103363870_103364326	0.63	Cdv3	carnitine deficiency-associated gene expressed in ventricle 3	799	0.56
chr5_87091073_87091224	0.63	Ugt2b36	UDP glucuronosyltransferase 2 family, polypeptide B36	9	0.96
chr12_35294499_35294705	0.62	Gm44396	predicted gene, 44396	14289	0.25
chr9_20730600_20730850	0.62	Olfm2	olfactomedin 2	2496	0.23
chr6_128504140_128504367	0.61	Pzp	PZP, alpha-2-macroglobulin like	9030	0.09
chr12_109991265_109991416	0.61	Gm34667	predicted gene, 34667	32533	0.1
chr10_53753298_53753451	0.61	Fam184a	family with sequence similarity 184, member A	2251	0.35
chr10_108074024_108074345	0.61	Gm47999	predicted gene, 47999	68248	0.12
chr6_71173018_71173198	0.60	Gm44427	predicted gene, 44427	8309	0.13
chr4_150685463_150685649	0.60	Gm16079	predicted gene 16079	6764	0.21
chr7_14430188_14430339	0.59	Sult2a8	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8	6184	0.17
chr5_113041682_113041833	0.58	Gm22740	predicted gene, 22740	2387	0.2
chr2_157536788_157536939	0.58	Gm14287	predicted gene 14287	7878	0.12
chr4_155200341_155200507	0.57	Ski	ski sarcoma viral oncogene homolog (avian)	12128	0.17
chr4_19696850_19697018	0.57	Wwp1	WW domain containing E3 ubiquitin protein ligase 1	12059	0.21
chr3_10298177_10298449	0.57	Fabp12	fatty acid binding protein 12	2861	0.14
chr10_71332846_71333050	0.57	Cisd1	CDGSH iron sulfur domain 1	12006	0.12
chrX_38451090_38451246	0.57	Lamp2	lysosomal-associated membrane protein 2	5246	0.2
chr8_71405347_71405498	0.56	Ankle1	ankyrin repeat and LEM domain containing 1	588	0.54
chr5_30187138_30187289	0.56	Hadhb	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	6981	0.12
chr10_69165945_69166107	0.56	Rhobtb1	Rho-related BTB domain containing 1	14592	0.16
chr1_163243306_163243486	0.56	Gm20471	predicted gene 20471	36960	0.15
chr18_21372400_21372792	0.55	Gm22886	predicted gene, 22886	8335	0.2
chr6_50180364_50180523	0.55	Mpp6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	143	0.97
chr19_36735506_36735662	0.55	Ppp1r3c	protein phosphatase 1, regulatory subunit 3C	1069	0.56
chr5_104513210_104513369	0.54	Thoc2l	THO complex subunit 2-like	4937	0.19
chr17_36032663_36032990	0.54	H2-T23	histocompatibility 2, T region locus 23	29	0.92
chr12_77290130_77290290	0.54	Fut8	fucosyltransferase 8	51145	0.13
chr17_5012388_5012845	0.53	Arid1b	AT rich interactive domain 1B (SWI-like)	16187	0.23
chr7_16604272_16604437	0.53	Gm29443	predicted gene 29443	9470	0.09
chr16_23319629_23319807	0.53	St6gal1	beta galactoside alpha 2,6 sialyltransferase 1	29248	0.15
chr15_100654416_100654567	0.53	Bin2	bridging integrator 2	2831	0.13
chr19_23024753_23025259	0.53	Gm50136	predicted gene, 50136	36448	0.17
chr17_29502998_29503149	0.53	Pim1	proviral integration site 1	9666	0.1
chr15_85668222_85668373	0.53	Lncppara	long noncoding RNA near Ppara	14681	0.14
chr18_20868985_20869147	0.53	Trappc8	trafficking protein particle complex 8	6143	0.22
chr12_118887325_118887612	0.51	Abcb5	ATP-binding cassette, sub-family B (MDR/TAP), member 5	3291	0.3
chr18_69669013_69669180	0.51	Tcf4	transcription factor 4	10603	0.29
chr6_141629422_141629807	0.51	Slco1b2	solute carrier organic anion transporter family, member 1b2	96	0.98
chr5_115490406_115490588	0.51	Gm24407	predicted gene, 24407	243	0.76
chr15_43615203_43615437	0.51	Emc2	ER membrane protein complex subunit 2	120410	0.06
chr5_38480616_38480794	0.51	Slc2a9	solute carrier family 2 (facilitated glucose transporter), member 9	399	0.85
chr7_75472656_75473119	0.51	Gm44834	predicted gene 44834	9112	0.16
chr14_93654246_93654648	0.50	Gm48967	predicted gene, 48967	35601	0.23
chr14_46545888_46546175	0.50	E130120K24Rik	RIKEN cDNA E130120K24 gene	10272	0.13
chr10_68268511_68268720	0.50	Arid5b	AT rich interactive domain 5B (MRF1-like)	10106	0.23
chr1_129250759_129250920	0.50	Thsd7b	thrombospondin, type I, domain containing 7B	22463	0.22
chr6_17554780_17555139	0.49	Met	met proto-oncogene	7986	0.24
chr3_116936111_116936286	0.49	Gm42892	predicted gene 42892	8132	0.15
chr11_35015732_35015915	0.49	Slit3	slit guidance ligand 3	105401	0.07
chr2_3412724_3412892	0.49	Meig1	meiosis expressed gene 1	5773	0.13
chr15_100304113_100304275	0.48	Mettl7a1	methyltransferase like 7A1	12	0.96
chr19_30195816_30196018	0.48	Gldc	glycine decarboxylase	20488	0.17
chr1_183382689_183382840	0.48	Taf1a	TATA-box binding protein associated factor, RNA polymerase I, A	6217	0.13
chr5_24696900_24697051	0.48	Gm26648	predicted gene, 26648	7715	0.13
chr6_72259555_72259838	0.47	Atoh8	atonal bHLH transcription factor 8	24119	0.13
chr10_111756586_111756764	0.47	Gm46193	predicted gene, 46193	11103	0.15
chr10_111936910_111937296	0.47	Krr1	KRR1, small subunit (SSU) processome component, homolog (yeast)	35561	0.12
chr17_29504253_29504439	0.46	Pim1	proviral integration site 1	10939	0.1
chr19_55166765_55167101	0.46	Tectb	tectorin beta	13800	0.17
chr16_10972025_10972219	0.46	Litaf	LPS-induced TN factor	3457	0.14
chr16_86808963_86809164	0.46	Gm32461	predicted gene, 32461	2550	0.28
chr2_48442189_48442365	0.46	Gm13481	predicted gene 13481	14968	0.23
chr3_133765600_133766533	0.45	Gm6135	prediticted gene 6135	25438	0.2
chr8_72216672_72216850	0.45	Fam32a	family with sequence similarity 32, member A	2969	0.12
chr6_121874198_121874349	0.45	Mug1	murinoglobulin 1	11304	0.19
chr14_116448226_116448591	0.44	Gm38045	predicted gene, 38045	301807	0.01
chr4_97757677_97758345	0.44	Gm12676	predicted gene 12676	622	0.75
chr6_17255791_17255960	0.44	Cav2	caveolin 2	25310	0.17
chr5_145464782_145464950	0.44	Cyp3a16	cytochrome P450, family 3, subfamily a, polypeptide 16	4857	0.19
chr15_79553946_79554106	0.44	Ddx17	DEAD (Asp-Glu-Ala-Asp) box polypeptide 17	7285	0.11
chr2_40852081_40852246	0.44	Gm13462	predicted gene 13462	106228	0.07
chr18_39827979_39828276	0.43	Pabpc2	poly(A) binding protein, cytoplasmic 2	54630	0.14
chr17_73839522_73839982	0.43	Gm4948	predicted gene 4948	31598	0.14
chr8_86154549_86154716	0.43	Gm23904	predicted gene, 23904	79222	0.1
chr2_165921904_165922055	0.43	Gm11461	predicted gene 11461	3862	0.16
chr1_23163206_23163464	0.43	Ppp1r14bl	protein phosphatase 1, regulatory inhibitor subunit 14B like	61082	0.1
chr1_174921018_174921617	0.43	Grem2	gremlin 2, DAN family BMP antagonist	502	0.88
chr6_108254587_108254738	0.43	Itpr1	inositol 1,4,5-trisphosphate receptor 1	1704	0.47
chr1_136229022_136229181	0.43	Inava	innate immunity activator	918	0.4
chr9_115403471_115403629	0.43	Gm9487	predicted gene 9487	1599	0.28
chr13_64237836_64238013	0.43	Cdc14b	CDC14 cell division cycle 14B	10718	0.1
chr17_10237978_10238400	0.42	Qk	quaking	24615	0.24
chr5_138106488_138106739	0.42	Gm43493	predicted gene 43493	294	0.77
chr6_13287887_13288060	0.42	AC121573.1	predicted 725	24228	0.22
chr2_45114016_45114230	0.41	Zeb2	zinc finger E-box binding homeobox 2	615	0.66
chr8_34506104_34506386	0.41	Gm8268	predicted gene 8268	962	0.54
chr6_120023528_120024062	0.41	Mir706	microRNA 706	10516	0.16
chr5_86725030_86725390	0.41	Gm16579	predicted gene 16579	3689	0.15
chr12_99418906_99419292	0.41	Foxn3	forkhead box N3	6494	0.18
chr14_27876257_27876427	0.41	Erc2	ELKS/RAB6-interacting/CAST family member 2	72	0.57
chr5_30926172_30926329	0.41	Khk	ketohexokinase	4364	0.09
chrX_60347501_60348092	0.41	Mir505	microRNA 505	46696	0.14
chr4_82643627_82643778	0.40	Gm11268	predicted gene 11268	1302	0.49
chr14_55682185_55682383	0.40	Gm49067	predicted gene, 49067	366	0.43
chr1_133251724_133252043	0.40	Gm19461	predicted gene, 19461	2409	0.23
chr12_31539489_31539733	0.40	Slc26a4	solute carrier family 26, member 4	3038	0.19
chr5_134992454_134992629	0.40	Cldn3	claudin 3	6327	0.08
chr13_22020926_22021324	0.40	Gm11290	predicted gene 11290	3619	0.06
chr7_73538202_73538544	0.40	Gm44686	predicted gene 44686	360	0.65
chr1_58112957_58113355	0.40	Aox3	aldehyde oxidase 3	18	0.98
chr11_100819438_100819589	0.40	Stat5b	signal transducer and activator of transcription 5B	3015	0.18
chr8_36820142_36820568	0.39	Dlc1	deleted in liver cancer 1	87301	0.09
chr12_57514709_57514889	0.39	Gm2568	predicted gene 2568	5825	0.17
chr2_44105283_44105434	0.39	Arhgap15os	Rho GTPase activating protein 15, opposite strand	40034	0.19
chr11_84865098_84865523	0.39	Ggnbp2	gametogenetin binding protein 2	4651	0.13
chr1_187214930_187215194	0.39	Spata17	spermatogenesis associated 17	359	0.55
chr17_86896356_86896548	0.39	Tmem247	transmembrane protein 247	20896	0.13
chr9_50501355_50501515	0.39	Plet1os	placenta expressed transcript 1, opposite strand	3370	0.16
chr10_96854885_96855043	0.39	Gm24587	predicted gene, 24587	706	0.71
chr10_108454541_108454850	0.39	Gm36283	predicted gene, 36283	8093	0.2
chr19_34518935_34519125	0.39	Lipa	lysosomal acid lipase A	8050	0.13
chr15_98609856_98610015	0.39	Adcy6	adenylate cyclase 6	97	0.93
chr8_91381593_91381994	0.39	Fto	fat mass and obesity associated	8762	0.16
chr1_30946725_30947101	0.39	Ptp4a1	protein tyrosine phosphatase 4a1	487	0.77
chr13_4034887_4035107	0.39	Gm18857	predicted gene, 18857	248	0.89
chr15_78804542_78804702	0.38	Card10	caspase recruitment domain family, member 10	1580	0.24
chr8_82249699_82250126	0.38	Gm38590	predicted gene, 38590	42377	0.17
chr10_111133507_111133671	0.38	Gm22101	predicted gene, 22101	4380	0.16
chr12_21142640_21142894	0.38	Asap2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	30813	0.16
chr11_101675430_101675600	0.38	Arl4d	ADP-ribosylation factor-like 4D	9974	0.1
chr8_127169398_127169549	0.38	Pard3	par-3 family cell polarity regulator	1931	0.45
chr3_50931112_50931300	0.37	Gm37843	predicted gene, 37843	9681	0.2
chr4_148085280_148085458	0.37	Agtrap	angiotensin II, type I receptor-associated protein	593	0.56
chr4_40698726_40698877	0.37	Aptx	aprataxin	3915	0.15
chr11_119558053_119558232	0.37	Gm11762	predicted gene 11762	9512	0.15
chr6_58989254_58989420	0.37	Gm45061	predicted gene 45061	16140	0.13
chr9_62118138_62118584	0.37	Mir5133	microRNA 5133	4233	0.22
chr19_53889976_53890197	0.37	Pdcd4	programmed cell death 4	2145	0.25
chr15_34510659_34511041	0.37	Pop1	processing of precursor 1, ribonuclease P/MRP family, (S. cerevisiae)	943	0.43
chr4_35101216_35101367	0.37	Ifnk	interferon kappa	50765	0.12
chr11_101395003_101395405	0.36	Gm25475	predicted gene, 25475	2564	0.09
chr1_187175642_187176011	0.36	Spata17	spermatogenesis associated 17	32729	0.12
chr4_21739391_21739542	0.36	Ccnc	cyclin C	11699	0.16
chr3_82275838_82275989	0.36	Map9	microtubule-associated protein 9	82131	0.1
chr18_11714442_11714593	0.36	Rbbp8	retinoblastoma binding protein 8, endonuclease	7704	0.21
chr16_32643661_32643943	0.36	Tnk2	tyrosine kinase, non-receptor, 2	72	0.96
chr3_98055157_98055314	0.36	Gm42819	predicted gene 42819	24548	0.16
chr19_4213519_4213699	0.36	Clcf1	cardiotrophin-like cytokine factor 1	629	0.3
chr19_21107216_21107509	0.36	4930554I06Rik	RIKEN cDNA 4930554I06 gene	2652	0.34
chr2_181487353_181487516	0.36	Abhd16b	abhydrolase domain containing 16B	5772	0.11
chr1_88165845_88166009	0.35	Ugt1a5	UDP glucuronosyltransferase 1 family, polypeptide A5	85	0.91
chr1_41555238_41555655	0.35	Gm28634	predicted gene 28634	25903	0.27
chr10_68355501_68355861	0.35	4930545H06Rik	RIKEN cDNA 4930545H06 gene	34539	0.17
chr14_69628830_69628981	0.35	Gm27177	predicted gene 27177	11369	0.11
chr6_16701529_16701791	0.35	Gm36669	predicted gene, 36669	75864	0.11

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.2	0.7	GO:0032417	positive regulation of sodium:proton antiporter activity(GO:0032417)
0.2	0.5	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1	0.4	GO:0010912	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.1	0.4	GO:0060300	regulation of cytokine activity(GO:0060300)
0.1	0.3	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.1	0.4	GO:0009115	xanthine catabolic process(GO:0009115)
0.1	0.3	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.1	0.2	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.1	0.2	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.1	0.5	GO:0005513	detection of calcium ion(GO:0005513)
0.1	0.2	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.1	0.3	GO:1900378	positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.1	0.2	GO:0015772	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.1	0.4	GO:0070327	thyroid hormone transport(GO:0070327)
0.1	0.2	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.1	0.2	GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.1	0.3	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.1	0.2	GO:0010482	epidermal cell division(GO:0010481) regulation of epidermal cell division(GO:0010482)
0.1	0.2	GO:0097503	sialylation(GO:0097503)
0.1	0.1	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.1	0.4	GO:0035811	negative regulation of urine volume(GO:0035811)
0.1	0.3	GO:0002591	antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway(GO:0002488) antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent(GO:0002489) positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591)
0.1	0.6	GO:0006857	oligopeptide transport(GO:0006857)
0.1	0.4	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:1901492	positive regulation of lymphangiogenesis(GO:1901492)
0.0	0.3	GO:0045040	protein import into mitochondrial outer membrane(GO:0045040)
0.0	0.2	GO:0046292	formaldehyde metabolic process(GO:0046292)
0.0	0.2	GO:0032364	oxygen homeostasis(GO:0032364)
0.0	0.2	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.2	GO:0035564	regulation of kidney size(GO:0035564)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.2	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0060051	negative regulation of protein glycosylation(GO:0060051)
0.0	0.1	GO:0075509	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.2	GO:0010825	positive regulation of centrosome duplication(GO:0010825)
0.0	0.1	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.2	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0	0.9	GO:0061014	positive regulation of mRNA catabolic process(GO:0061014)
0.0	0.1	GO:0010909	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.3	GO:0046415	urate metabolic process(GO:0046415)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.1	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.0	0.1	GO:1901859	negative regulation of mitochondrial DNA metabolic process(GO:1901859)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.1	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.3	GO:2000392	regulation of lamellipodium morphogenesis(GO:2000392)
0.0	0.1	GO:0044375	regulation of peroxisome size(GO:0044375)
0.0	0.1	GO:0032907	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.3	GO:0046085	adenosine metabolic process(GO:0046085)
0.0	0.1	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.1	GO:0051599	response to hydrostatic pressure(GO:0051599)
0.0	0.1	GO:0051902	negative regulation of mitochondrial depolarization(GO:0051902)
0.0	0.1	GO:0033578	protein glycosylation in Golgi(GO:0033578)
0.0	0.2	GO:0016078	tRNA catabolic process(GO:0016078)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.0	GO:0001306	age-dependent response to oxidative stress(GO:0001306) age-dependent general metabolic decline(GO:0007571)
0.0	0.2	GO:1903551	regulation of extracellular exosome assembly(GO:1903551)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0046552	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0	0.2	GO:0016266	O-glycan processing(GO:0016266)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.0	0.1	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.1	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0	0.1	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.1	GO:0030997	regulation of centriole-centriole cohesion(GO:0030997)
0.0	0.2	GO:0038166	angiotensin-activated signaling pathway(GO:0038166)
0.0	0.1	GO:0090259	regulation of retinal ganglion cell axon guidance(GO:0090259)
0.0	0.1	GO:0071635	negative regulation of transforming growth factor beta production(GO:0071635)
0.0	0.1	GO:0048295	positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0	0.1	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.2	GO:0008090	retrograde axonal transport(GO:0008090)
0.0	0.1	GO:0070350	white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.0	0.1	GO:0016344	meiotic chromosome movement towards spindle pole(GO:0016344)
0.0	0.1	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.1	GO:0042118	endothelial cell activation(GO:0042118)
0.0	0.6	GO:0002089	lens morphogenesis in camera-type eye(GO:0002089)
0.0	0.1	GO:0036216	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0	0.2	GO:0034063	stress granule assembly(GO:0034063)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.1	GO:0060971	embryonic heart tube left/right pattern formation(GO:0060971)
0.0	0.1	GO:0061684	chaperone-mediated autophagy(GO:0061684)
0.0	0.0	GO:0043134	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.0	0.2	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0072378	blood coagulation, fibrin clot formation(GO:0072378)
0.0	0.0	GO:0014016	neuroblast differentiation(GO:0014016)
0.0	0.1	GO:0046881	positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0060083	smooth muscle contraction involved in micturition(GO:0060083)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.1	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.0	GO:0045608	negative regulation of auditory receptor cell differentiation(GO:0045608)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.0	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.0	0.1	GO:0070537	histone H2A K63-linked deubiquitination(GO:0070537)
0.0	0.0	GO:0010847	regulation of chromatin assembly(GO:0010847)
0.0	0.1	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.0	GO:0072300	positive regulation of metanephric glomerulus development(GO:0072300)
0.0	0.2	GO:0046838	phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0	0.0	GO:0046391	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0	0.1	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.2	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:1901674	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.1	GO:0051660	establishment of centrosome localization(GO:0051660)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.1	GO:2000643	positive regulation of early endosome to late endosome transport(GO:2000643)
0.0	0.0	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.0	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.2	GO:0060294	cilium movement involved in cell motility(GO:0060294)
0.0	0.2	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.2	GO:0035563	positive regulation of chromatin binding(GO:0035563)
0.0	0.0	GO:0060700	regulation of ribonuclease activity(GO:0060700)
0.0	0.1	GO:0021555	midbrain-hindbrain boundary morphogenesis(GO:0021555)
0.0	0.1	GO:0060160	negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0035633	maintenance of blood-brain barrier(GO:0035633)
0.0	0.2	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.1	GO:0006991	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0	0.0	GO:0035262	gonad morphogenesis(GO:0035262)
0.0	0.2	GO:0031269	pseudopodium assembly(GO:0031269)
0.0	0.0	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.0	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.0	0.1	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0	0.0	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.2	GO:0036297	interstrand cross-link repair(GO:0036297)
0.0	0.2	GO:0090136	epithelial cell-cell adhesion(GO:0090136)
0.0	0.0	GO:0003166	bundle of His development(GO:0003166)
0.0	0.0	GO:0033762	response to glucagon(GO:0033762)
0.0	0.1	GO:0002317	plasma cell differentiation(GO:0002317)
0.0	0.1	GO:0061304	retinal blood vessel morphogenesis(GO:0061304)
0.0	0.1	GO:0048633	positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0	0.1	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.0	0.0	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
0.0	0.0	GO:1990314	cellular response to insulin-like growth factor stimulus(GO:1990314)
0.0	0.1	GO:0046146	tetrahydrobiopterin metabolic process(GO:0046146)
0.0	0.0	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
0.0	0.0	GO:0021938	smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
0.0	0.1	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0006501	C-terminal protein lipidation(GO:0006501)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.0	GO:0090071	negative regulation of ribosome biogenesis(GO:0090071)
0.0	0.2	GO:0035879	lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873) plasma membrane lactate transport(GO:0035879)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.7	GO:0048041	cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.0	0.1	GO:2000391	regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.1	GO:0018406	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.1	GO:0090188	negative regulation of pancreatic juice secretion(GO:0090188)
0.0	0.0	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.0	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.0	GO:0032906	transforming growth factor beta2 production(GO:0032906) regulation of transforming growth factor beta2 production(GO:0032909)
0.0	0.1	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.0	0.2	GO:0007250	activation of NF-kappaB-inducing kinase activity(GO:0007250)
0.0	0.1	GO:0006744	ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.0	GO:2000667	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.3	GO:0019585	uronic acid metabolic process(GO:0006063) glucuronate metabolic process(GO:0019585)
0.0	0.1	GO:0051764	actin crosslink formation(GO:0051764)
0.0	0.0	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.0	GO:0070458	detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0	0.1	GO:0048934	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.0	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0	0.1	GO:2001241	positive regulation of extrinsic apoptotic signaling pathway in absence of ligand(GO:2001241)
0.0	0.0	GO:2001025	positive regulation of response to drug(GO:2001025)
0.0	0.0	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.1	GO:0042760	very long-chain fatty acid catabolic process(GO:0042760)
0.0	0.0	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.0	0.1	GO:0090520	sphingolipid mediated signaling pathway(GO:0090520)
0.0	0.0	GO:0032513	negative regulation of protein phosphatase type 2B activity(GO:0032513)
0.0	0.1	GO:0038003	opioid receptor signaling pathway(GO:0038003)
0.0	0.0	GO:1901727	positive regulation of histone deacetylase activity(GO:1901727)
0.0	0.0	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.0	GO:0002315	marginal zone B cell differentiation(GO:0002315)
0.0	0.0	GO:0061643	chemorepulsion of axon(GO:0061643)
0.0	0.1	GO:1904668	positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0	0.0	GO:0010871	negative regulation of receptor biosynthetic process(GO:0010871)
0.0	0.0	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0	0.0	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.0	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.1	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.2	GO:0071425	hematopoietic stem cell proliferation(GO:0071425)
0.0	0.0	GO:0002125	maternal aggressive behavior(GO:0002125)
0.0	0.0	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.0	GO:0044034	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.1	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.1	GO:2000210	positive regulation of anoikis(GO:2000210)
0.0	0.0	GO:0007529	establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.0	0.0	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.0	0.0	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.0	GO:0007182	common-partner SMAD protein phosphorylation(GO:0007182)
0.0	0.0	GO:0097106	postsynaptic density organization(GO:0097106) postsynaptic density assembly(GO:0097107)
0.0	0.0	GO:0043987	histone H3-S10 phosphorylation(GO:0043987)
0.0	0.0	GO:0007042	lysosomal lumen acidification(GO:0007042)
0.0	0.0	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.1	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	0.2	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.1	0.3	GO:0071203	WASH complex(GO:0071203)
0.1	0.2	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.1	0.4	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.1	0.2	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.1	0.2	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.7	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.4	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.5	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.3	GO:0044300	cerebellar mossy fiber(GO:0044300)
0.0	0.3	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0097058	CRLF-CLCF1 complex(GO:0097058)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.5	GO:0031045	dense core granule(GO:0031045)
0.0	0.2	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.3	GO:0005742	mitochondrial outer membrane translocase complex(GO:0005742)
0.0	0.1	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.1	GO:0005767	secondary lysosome(GO:0005767)
0.0	0.1	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.2	GO:0045179	apical cortex(GO:0045179)
0.0	0.1	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0070531	BRCA1-A complex(GO:0070531)
0.0	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.2	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.1	GO:0020018	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0	0.0	GO:0043511	inhibin complex(GO:0043511)
0.0	0.2	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.2	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.1	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.2	GO:0032580	Golgi cisterna membrane(GO:0032580)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.1	GO:0070187	telosome(GO:0070187)
0.0	0.0	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.0	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
0.0	0.1	GO:0044194	cytolytic granule(GO:0044194)
0.0	0.3	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0071437	invadopodium(GO:0071437)
0.0	0.2	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.1	GO:1904115	axon cytoplasm(GO:1904115)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.0	GO:0034457	Mpp10 complex(GO:0034457)
0.0	0.2	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:0060091	kinocilium(GO:0060091)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0008290	F-actin capping protein complex(GO:0008290)
0.0	0.1	GO:0034363	intermediate-density lipoprotein particle(GO:0034363)
0.0	0.4	GO:0098636	protein complex involved in cell adhesion(GO:0098636)
0.0	0.1	GO:0098651	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0020003	symbiont-containing vacuole(GO:0020003)
0.0	0.1	GO:0000788	nuclear nucleosome(GO:0000788)
0.0	0.1	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.0	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.1	GO:0000235	astral microtubule(GO:0000235)
0.0	0.1	GO:0016580	Sin3 complex(GO:0016580)
0.0	0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.1	0.4	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1	0.3	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.1	0.6	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.1	0.4	GO:0030151	molybdenum ion binding(GO:0030151)
0.1	0.4	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1	0.6	GO:0004385	guanylate kinase activity(GO:0004385)
0.1	0.2	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.1	0.2	GO:0015154	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.1	0.2	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.1	0.2	GO:0031735	CCR10 chemokine receptor binding(GO:0031735)
0.1	0.2	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.1	0.4	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.6	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.2	GO:0004945	angiotensin type II receptor activity(GO:0004945)
0.0	0.2	GO:0019960	C-X3-C chemokine binding(GO:0019960)
0.0	0.2	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.1	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.0	0.2	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.3	GO:0036122	BMP binding(GO:0036122)
0.0	0.8	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.2	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	0.1	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.2	GO:0034889	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0	0.3	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0046848	hydroxyapatite binding(GO:0046848)
0.0	0.1	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.0	0.1	GO:0017002	activin-activated receptor activity(GO:0017002)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.1	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.3	GO:0015266	protein channel activity(GO:0015266)
0.0	0.1	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0033695	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0015111	iodide transmembrane transporter activity(GO:0015111)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.5	GO:0017075	syntaxin-1 binding(GO:0017075)
0.0	0.2	GO:0001091	RNA polymerase II basal transcription factor binding(GO:0001091)
0.0	0.1	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.1	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.1	GO:0003987	acetate-CoA ligase activity(GO:0003987)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:0043398	HLH domain binding(GO:0043398)
0.0	0.1	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.9	GO:0004712	protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.2	GO:0035925	mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.0	0.1	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.0	GO:0004698	calcium-dependent protein kinase C activity(GO:0004698)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.2	GO:1990381	ubiquitin-specific protease binding(GO:1990381)
0.0	0.1	GO:0052833	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.0	0.1	GO:0035033	histone deacetylase regulator activity(GO:0035033)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.5	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.2	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.1	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.2	GO:0098599	palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.0	0.1	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	0.1	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.1	GO:0005534	galactose binding(GO:0005534)
0.0	0.1	GO:0031748	D1 dopamine receptor binding(GO:0031748)
0.0	0.0	GO:0070905	serine binding(GO:0070905)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0015238	drug transmembrane transporter activity(GO:0015238)
0.0	0.2	GO:0051765	inositol tetrakisphosphate kinase activity(GO:0051765)
0.0	0.1	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.1	GO:0019869	chloride channel inhibitor activity(GO:0019869)
0.0	0.0	GO:0036435	K48-linked polyubiquitin binding(GO:0036435)
0.0	0.1	GO:0003840	gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.0	0.1	GO:0003841	1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.0	0.1	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	0.1	GO:0016661	oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.0	0.0	GO:0030519	snoRNP binding(GO:0030519)
0.0	0.2	GO:0031005	filamin binding(GO:0031005)
0.0	0.2	GO:0015129	lactate transmembrane transporter activity(GO:0015129)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.0	GO:0035514	DNA demethylase activity(GO:0035514)
0.0	0.2	GO:0043274	phospholipase binding(GO:0043274)
0.0	0.1	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.1	GO:1990932	5.8S rRNA binding(GO:1990932)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0001162	RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.2	GO:0070064	proline-rich region binding(GO:0070064)
0.0	0.1	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0002060	purine nucleobase binding(GO:0002060)
0.0	0.0	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.0	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.0	GO:0032051	clathrin light chain binding(GO:0032051)
0.0	0.1	GO:0048531	beta-1,3-galactosyltransferase activity(GO:0048531)
0.0	0.0	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0035252	UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0	0.6	GO:0048306	calcium-dependent protein binding(GO:0048306)
0.0	0.0	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.1	GO:0097371	MDM2/MDM4 family protein binding(GO:0097371)
0.0	0.0	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.5	GO:0050694	galactose 3-O-sulfotransferase activity(GO:0050694)
0.0	0.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.0	GO:0005415	nucleoside:sodium symporter activity(GO:0005415)
0.0	0.1	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.0	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.1	GO:0043024	ribosomal small subunit binding(GO:0043024)
0.0	0.3	GO:0050699	WW domain binding(GO:0050699)
0.0	0.1	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.0	GO:0061665	SUMO ligase activity(GO:0061665)
0.0	0.0	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0005536	glucose binding(GO:0005536)
0.0	0.0	GO:0001031	RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0	0.0	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.2	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	0.1	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.0	GO:0034511	U3 snoRNA binding(GO:0034511)
0.0	0.1	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0005345	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.5	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.5	PID CDC42 REG PATHWAY	Regulation of CDC42 activity
0.1	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.5	SIG CD40PATHWAYMAP	Genes related to CD40 signaling
0.2	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.0	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1	SA B CELL RECEPTOR COMPLEXES	Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.1	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.2	ST GAQ PATHWAY	G alpha q Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.5	REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS	Genes involved in Facilitative Na+-independent glucose transporters
0.4	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.4	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.3	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.4	REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS	Genes involved in Ionotropic activity of Kainate Receptors
0.3	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.2	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.4	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1	REACTOME PACKAGING OF TELOMERE ENDS	Genes involved in Packaging Of Telomere Ends
0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.4	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	REACTOME RNA POL III TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase III Transcription Termination
0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.1	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.2	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.3	REACTOME SEMA4D IN SEMAPHORIN SIGNALING	Genes involved in Sema4D in semaphorin signaling
0.1	REACTOME TRAF6 MEDIATED INDUCTION OF TAK1 COMPLEX	Genes involved in TRAF6 mediated induction of TAK1 complex
0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.1	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.1	REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP	Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0	REACTOME CDT1 ASSOCIATION WITH THE CDC6 ORC ORIGIN COMPLEX	Genes involved in CDT1 association with the CDC6:ORC:origin complex
0.1	REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	Genes involved in Apoptosis induced DNA fragmentation
0.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS	Genes involved in Activation of the AP-1 family of transcription factors
0.3	REACTOME SYNTHESIS OF PA	Genes involved in Synthesis of PA

Results for Lhx3

Z-value: 1.65

Motif logo

Transcription factors associated with Lhx3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Lhx3 motif across conditions

Conditions sorted by the z-value of the Lhx3 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: