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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Lhx4

Z-value: 0.70

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Transcription factors associated with Lhx4

Gene Symbol	Gene ID	Gene Info
Lhx4 Ensembl NCBI MGI UniProt	ENSMUSG00000026468.8	LIM homeobox protein 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr1_155721550_155721719	Lhx4	20393	0.145526	0.45	3.7e-01	Click!
chr1_155720147_155720298	Lhx4	21805	0.143623	-0.01	9.9e-01	Click!

Activity of the Lhx4 motif across conditions

Conditions sorted by the z-value of the Lhx4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_39133288_39133558	0.43	Gm37091	predicted gene, 37091	50085	0.11
chr5_99976807_99976958	0.36	Hnrnpd	heterogeneous nuclear ribonucleoprotein D	331	0.73
chr5_22506386_22506555	0.36	Orc5	origin recognition complex, subunit 5	16196	0.12
chr2_34049474_34049625	0.35	C230014O12Rik	RIKEN cDNA C230014O12 gene	58180	0.11
chr4_88889115_88889274	0.32	Ifne	interferon epsilon	8993	0.08
chr9_106264996_106265377	0.32	Poc1a	POC1 centriolar protein A	15875	0.1
chr10_125785978_125786129	0.31	Lrig3	leucine-rich repeats and immunoglobulin-like domains 3	180115	0.03
chr2_31519719_31520357	0.31	Ass1	argininosuccinate synthetase 1	1548	0.36
chr10_69208679_69208830	0.30	Rhobtb1	Rho-related BTB domain containing 1	202	0.94
chr4_76367194_76367568	0.29	Ptprd	protein tyrosine phosphatase, receptor type, D	23138	0.21
chr7_118151770_118151921	0.29	Gm25683	predicted gene, 25683	1635	0.32
chr15_61562347_61562502	0.28	Gm49498	predicted gene, 49498	18241	0.28
chr19_20628055_20628251	0.28	Aldh1a1	aldehyde dehydrogenase family 1, subfamily A1	26192	0.19
chr1_84128867_84129018	0.28	Gm37058	predicted gene, 37058	5568	0.25
chr5_20590046_20590233	0.28	Gm3544	predicted gene 3544	1543	0.45
chr14_30530847_30531018	0.27	Dcp1a	decapping mRNA 1A	7225	0.15
chr6_108836766_108836917	0.27	Edem1	ER degradation enhancer, mannosidase alpha-like 1	431	0.86
chr11_35732740_35732891	0.26	Pank3	pantothenate kinase 3	36669	0.14
chr6_100267052_100267222	0.26	Gm44044	predicted gene, 44044	6561	0.17
chr19_7500165_7500363	0.25	Atl3	atlastin GTPase 3	5729	0.15
chr2_154875946_154876097	0.25	Eif2s2	eukaryotic translation initiation factor 2, subunit 2 (beta)	16761	0.19
chr6_72120521_72121047	0.25	4933431G14Rik	RIKEN cDNA 4933431G14 gene	2156	0.2
chr17_66754427_66754593	0.24	Gm47471	predicted gene, 47471	15756	0.14
chr1_67222842_67222998	0.24	Gm15668	predicted gene 15668	26280	0.19
chr10_37324159_37324310	0.23	Gm26535	predicted gene, 26535	13252	0.25
chr10_89573725_89573906	0.23	Gm48087	predicted gene, 48087	18096	0.17
chr9_55280024_55280330	0.23	Nrg4	neuregulin 4	3395	0.23
chr11_21121403_21121623	0.23	Peli1	pellino 1	13956	0.18
chr17_32257244_32257401	0.23	Brd4	bromodomain containing 4	15043	0.12
chrX_49489499_49489695	0.23	Arhgap36	Rho GTPase activating protein 36	3922	0.27
chr6_29571610_29572022	0.23	Tnpo3	transportin 3	297	0.87
chr13_107645708_107645859	0.22	Gm32090	predicted gene, 32090	32934	0.17
chr2_72309170_72309345	0.22	Map3k20	mitogen-activated protein kinase kinase kinase 20	11356	0.19
chr10_87040962_87041138	0.22	1700113H08Rik	RIKEN cDNA 1700113H08 gene	16995	0.16
chr15_6218493_6218848	0.22	Gm23139	predicted gene, 23139	67322	0.11
chr4_63773592_63773743	0.22	Tnfsf15	tumor necrosis factor (ligand) superfamily, member 15	28554	0.18
chr11_31875210_31875374	0.22	Cpeb4	cytoplasmic polyadenylation element binding protein 4	2017	0.35
chr8_105069434_105069585	0.22	Ces3b	carboxylesterase 3B	14244	0.09
chr3_60097287_60097456	0.22	Sucnr1	succinate receptor 1	15469	0.18
chr2_70666883_70667034	0.22	Gorasp2	golgi reassembly stacking protein 2	4758	0.18
chr1_100298746_100298897	0.22	Gm29667	predicted gene 29667	16030	0.18
chr12_51274477_51274668	0.22	Rps11-ps4	ribosomal protein S11, pseudogene 4	22915	0.22
chr5_90364825_90365036	0.22	Ankrd17	ankyrin repeat domain 17	1255	0.37
chr4_123990393_123990580	0.22	Gm12902	predicted gene 12902	64252	0.08
chr6_72897626_72897819	0.22	Kcmf1	potassium channel modulatory factor 1	1361	0.34
chr19_60570173_60570324	0.21	Gm25238	predicted gene, 25238	10281	0.18
chr6_49217272_49217620	0.21	Igf2bp3	insulin-like growth factor 2 mRNA binding protein 3	2489	0.23
chr9_118689127_118689278	0.21	Itga9	integrin alpha 9	3367	0.3
chr10_22004298_22004461	0.21	Sgk1	serum/glucocorticoid regulated kinase 1	7788	0.15
chr2_127608341_127608498	0.21	Mrps5	mitochondrial ribosomal protein S5	8386	0.13
chr1_67213641_67214357	0.21	Gm15668	predicted gene 15668	35201	0.17
chr8_93189262_93189430	0.21	Gm45909	predicted gene 45909	2012	0.24
chr19_27328502_27328670	0.21	Kcnv2	potassium channel, subfamily V, member 2	5998	0.19
chr12_73341772_73342027	0.20	Slc38a6	solute carrier family 38, member 6	2468	0.25
chr6_141634890_141635041	0.20	Slco1b2	solute carrier organic anion transporter family, member 1b2	507	0.86
chr11_90184166_90184514	0.20	n-R5s72	nuclear encoded rRNA 5S 72	787	0.57
chr1_77168235_77168428	0.20	Gm38265	predicted gene, 38265	21339	0.22
chr11_28696253_28696446	0.19	2810471M01Rik	RIKEN cDNA 2810471M01 gene	14785	0.17
chr6_101095542_101095693	0.19	Gm43948	predicted gene, 43948	36446	0.13
chr9_9091904_9092129	0.19	Gm16485	predicted gene 16485	120225	0.06
chr1_73954752_73954963	0.19	Tns1	tensin 1	8186	0.24
chr11_98339208_98339359	0.19	Ppp1r1b	protein phosphatase 1, regulatory inhibitor subunit 1B	9121	0.09
chr3_131269432_131269662	0.19	Hadh	hydroxyacyl-Coenzyme A dehydrogenase	2477	0.24
chr1_127787130_127787281	0.19	Ccnt2	cyclin T2	9366	0.16
chr4_131876493_131876847	0.19	A930004J17Rik	RIKEN cDNA A930004J17 gene	1958	0.19
chr10_42211682_42211846	0.18	Foxo3	forkhead box O3	46602	0.16
chr2_38823684_38823849	0.18	Nr6a1os	nuclear receptor subfamily 6, group A, member 1, opposite strand	425	0.74
chr4_32300145_32300312	0.18	Bach2it1	BTB and CNC homology 2, intronic transcript 1	48467	0.14
chr3_118588032_118588183	0.18	Dpyd	dihydropyrimidine dehydrogenase	25921	0.17
chr4_134814659_134814853	0.18	Maco1	macoilin 1	3543	0.24
chr19_31886956_31887132	0.18	A1cf	APOBEC1 complementation factor	18263	0.2
chr9_54139319_54139478	0.18	Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	42676	0.14
chr1_183438610_183438761	0.18	Gm37214	predicted gene, 37214	18030	0.13
chr3_158035265_158035416	0.18	Gm43362	predicted gene 43362	1069	0.28
chr12_79436402_79436553	0.18	Rad51b	RAD51 paralog B	109124	0.06
chr17_10187170_10187336	0.18	Qk	quaking	26321	0.25
chr7_112825614_112825993	0.18	Tead1	TEA domain family member 1	13831	0.24
chr4_123419684_123419835	0.18	Macf1	microtubule-actin crosslinking factor 1	7531	0.17
chr3_70400102_70400273	0.18	Gm6631	predicted gene 6631	13132	0.29
chr4_76435923_76436234	0.18	Ptprd	protein tyrosine phosphatase, receptor type, D	13902	0.21
chr2_155378239_155378390	0.18	Trp53inp2	transformation related protein 53 inducible nuclear protein 2	2745	0.19
chr19_55891664_55891815	0.18	Tcf7l2	transcription factor 7 like 2, T cell specific, HMG box	1613	0.48
chr3_108701624_108701775	0.18	Gpsm2	G-protein signalling modulator 2 (AGS3-like, C. elegans)	814	0.52
chr16_37606843_37607024	0.17	Gm46559	predicted gene, 46559	10743	0.15
chr10_87936931_87937082	0.17	Tyms-ps	thymidylate synthase, pseudogene	29841	0.15
chr5_87130645_87130796	0.17	Ugt2b5	UDP glucuronosyltransferase 2 family, polypeptide B5	9598	0.12
chr9_115270461_115270612	0.17	Stmn1-rs1	stathmin 1, related sequence 1	11445	0.17
chr13_31779124_31779297	0.17	Gm11379	predicted gene 11379	18329	0.16
chr3_131485378_131485553	0.17	Sgms2	sphingomyelin synthase 2	5014	0.28
chr19_39287276_39287531	0.17	Cyp2c29	cytochrome P450, family 2, subfamily c, polypeptide 29	329	0.91
chr17_80022007_80022158	0.17	Gm22215	predicted gene, 22215	11432	0.14
chr16_43375815_43375981	0.17	Zbtb20	zinc finger and BTB domain containing 20	11694	0.17
chr15_12577123_12577293	0.17	Gm2606	predicted pseudogene 2606	2319	0.26
chr8_89407033_89407242	0.17	Gm26331	predicted gene, 26331	182404	0.03
chr6_13654409_13654594	0.17	Bmt2	base methyltransferase of 25S rRNA 2	23437	0.21
chr4_63738674_63738850	0.17	Tnfsf15	tumor necrosis factor (ligand) superfamily, member 15	6351	0.22
chr17_51511001_51511172	0.17	Gm31143	predicted gene, 31143	23772	0.19
chr6_71999696_71999905	0.17	Gm26628	predicted gene, 26628	36025	0.1
chr19_39460982_39461329	0.17	Cyp2c38	cytochrome P450, family 2, subfamily c, polypeptide 38	1920	0.42
chr15_3721208_3721477	0.17	Gm4823	predicted gene 4823	25533	0.23
chr17_79018863_79019084	0.17	Prkd3	protein kinase D3	1804	0.3
chr13_102625798_102626135	0.17	Gm47014	predicted gene, 47014	21433	0.2
chr2_48981052_48981464	0.16	Orc4	origin recognition complex, subunit 4	30981	0.18
chr10_56437367_56437519	0.16	4930452L12Rik	RIKEN cDNA 4930452L12 gene	160	0.95
chr3_108496483_108496708	0.16	Gm23336	predicted gene, 23336	1523	0.23
chr14_64444658_64444809	0.16	Msra	methionine sulfoxide reductase A	3816	0.31
chr11_77770194_77770550	0.16	Myo18a	myosin XVIIIA	1779	0.27
chr1_124069161_124069328	0.16	Dpp10	dipeptidylpeptidase 10	23685	0.27
chr19_48883437_48883771	0.16	Gm50436	predicted gene, 50436	72468	0.11
chr4_57160943_57161117	0.16	Gm12530	predicted gene 12530	11041	0.2
chr12_55420887_55421038	0.16	Psma6	proteasome subunit alpha 6	13579	0.16
chr3_52271842_52271993	0.16	Gm20402	predicted gene 20402	2482	0.19
chr5_86919547_86919811	0.16	Gm25211	predicted gene, 25211	3357	0.13
chr1_15616194_15616345	0.16	Gm37138	predicted gene, 37138	60020	0.12
chr9_15301981_15302132	0.16	4931406C07Rik	RIKEN cDNA 4931406C07 gene	500	0.46
chr17_28283665_28283835	0.16	Ppard	peroxisome proliferator activator receptor delta	9496	0.11
chr16_24892958_24893109	0.16	Gm22672	predicted gene, 22672	8860	0.25
chr19_8373854_8374041	0.16	Slc22a30	solute carrier family 22, member 30	31113	0.16
chr2_124852123_124852274	0.16	Gm13994	predicted gene 13994	143543	0.04
chr6_41044689_41044854	0.16	2210010C04Rik	RIKEN cDNA 2210010C04 gene	9262	0.07
chr2_136449372_136449559	0.16	Gm14054	predicted gene 14054	46043	0.13
chr6_15283034_15283262	0.16	Foxp2	forkhead box P2	28865	0.25
chr17_89653592_89653743	0.16	Gm50061	predicted gene, 50061	98859	0.09
chr18_10707142_10707343	0.16	4930563E18Rik	RIKEN cDNA 4930563E18 gene	382	0.52
chr1_13715965_13716146	0.16	Xkr9	X-linked Kx blood group related 9	47284	0.12
chr4_15029409_15029632	0.16	Gm11844	predicted gene 11844	6938	0.27
chr3_138223407_138223558	0.16	Adh7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	2011	0.23
chr10_87541080_87541552	0.16	Pah	phenylalanine hydroxylase	5357	0.23
chr5_90322868_90323041	0.16	Ankrd17	ankyrin repeat domain 17	16789	0.19
chr5_123975512_123975863	0.16	Hip1r	huntingtin interacting protein 1 related	2059	0.19
chr10_12645976_12646209	0.16	Utrn	utrophin	31261	0.22
chr13_62872928_62873142	0.16	Fbp1	fructose bisphosphatase 1	277	0.87
chr8_35559883_35560059	0.16	Mfhas1	malignant fibrous histiocytoma amplified sequence 1	27827	0.15
chr8_90907363_90907534	0.16	Gm6658	predicted gene 6658	967	0.37
chr7_71467703_71467871	0.16	Gm29328	predicted gene 29328	97454	0.07
chr11_88277047_88277211	0.16	Ccdc182	coiled-coil domain containing 182	16929	0.15
chr10_128978991_128979196	0.15	9030616G12Rik	RIKEN cDNA 9030616G12 gene	7896	0.09
chr1_80334794_80334975	0.15	Cul3	cullin 3	5395	0.16
chr14_7835138_7835309	0.15	Flnb	filamin, beta	17266	0.15
chr3_133750379_133750596	0.15	Gm6135	prediticted gene 6135	41017	0.15
chr5_45491887_45492071	0.15	Lap3	leucine aminopeptidase 3	1395	0.31
chr5_25247792_25247943	0.15	Galnt11	polypeptide N-acetylgalactosaminyltransferase 11	504	0.76
chr16_70352273_70352442	0.15	Gbe1	glucan (1,4-alpha-), branching enzyme 1	38223	0.19
chr7_115674458_115674622	0.15	Sox6	SRY (sex determining region Y)-box 6	12175	0.3
chr13_58209928_58210079	0.15	Ubqln1	ubiquilin 1	5616	0.11
chr5_40908767_40908928	0.15	4930519E07Rik	RIKEN cDNA 4930519E07 gene	372389	0.01
chr9_7216362_7216525	0.15	Dcun1d5	DCN1, defective in cullin neddylation 1, domain containing 5 (S. cerevisiae)	12958	0.17
chr17_84990758_84990958	0.15	Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	2815	0.25
chr13_115653330_115653690	0.15	Gm47892	predicted gene, 47892	65989	0.13
chr5_150650487_150650670	0.14	N4bp2l2	NEDD4 binding protein 2-like 2	2317	0.19
chr10_117123042_117123236	0.14	Frs2	fibroblast growth factor receptor substrate 2	7707	0.15
chr1_91258114_91258381	0.14	Ube2f	ubiquitin-conjugating enzyme E2F (putative)	6340	0.15
chr14_21599276_21599451	0.14	Kat6b	K(lysine) acetyltransferase 6B	23179	0.21
chr12_12940858_12941058	0.14	Mycn	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	342	0.83
chr3_69115488_69115663	0.14	Gm37558	predicted gene, 37558	7149	0.14
chr8_110644559_110644860	0.14	Vac14	Vac14 homolog (S. cerevisiae)	871	0.63
chr15_59231191_59231350	0.14	Gm7691	predicted gene 7691	7219	0.19
chr5_53656682_53656871	0.14	Rbpj	recombination signal binding protein for immunoglobulin kappa J region	11038	0.24
chr11_80247133_80247304	0.14	Rhot1	ras homolog family member T1	2456	0.28
chr17_28428613_28428954	0.14	Fkbp5	FK506 binding protein 5	154	0.91
chr10_28178649_28178847	0.14	Gm22370	predicted gene, 22370	35373	0.21
chr18_65154932_65155123	0.14	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	707	0.74
chr4_40698726_40698877	0.14	Aptx	aprataxin	3915	0.15
chr4_72144165_72144326	0.14	Tle1	transducin-like enhancer of split 1	2932	0.31
chr11_6025571_6025816	0.14	Camk2b	calcium/calmodulin-dependent protein kinase II, beta	25245	0.15
chr16_72808058_72808236	0.14	Robo1	roundabout guidance receptor 1	144943	0.05
chr16_24449611_24449762	0.14	Lpp	LIM domain containing preferred translocation partner in lipoma	1595	0.42
chr12_83926450_83926603	0.14	Numb	NUMB endocytic adaptor protein	4592	0.13
chr1_172700535_172700739	0.14	Crp	C-reactive protein, pentraxin-related	2581	0.25
chr5_73970292_73970468	0.14	C78283	expressed sequence C78283	23999	0.14
chr12_86641903_86642073	0.14	Gm8504	predicted gene 8504	8585	0.17
chr3_65950089_65950240	0.14	Ccnl1	cyclin L1	814	0.48
chr7_64186221_64186468	0.14	Trpm1	transient receptor potential cation channel, subfamily M, member 1	743	0.57
chr1_119646750_119646988	0.14	Epb41l5	erythrocyte membrane protein band 4.1 like 5	1748	0.32
chr6_8862762_8862913	0.14	Ica1	islet cell autoantigen 1	84349	0.1
chr11_100975850_100976001	0.14	Cavin1	caveolae associated 1	5038	0.14
chr14_62736570_62736721	0.14	Ints6	integrator complex subunit 6	24467	0.14
chr2_144369139_144369688	0.14	Kat14	lysine acetyltransferase 14	414	0.43
chr4_124809297_124809476	0.14	Mtf1	metal response element binding transcription factor 1	6708	0.1
chr2_69724299_69724450	0.13	Ppig	peptidyl-prolyl isomerase G (cyclophilin G)	1048	0.4
chr2_73276147_73276506	0.13	Sp9	trans-acting transcription factor 9	4360	0.18
chr5_122060223_122060392	0.13	Cux2	cut-like homeobox 2	10205	0.14
chr8_90945191_90945444	0.13	Chd9	chromodomain helicase DNA binding protein 9	9641	0.17
chr1_9985468_9985649	0.13	Ppp1r42	protein phosphatase 1, regulatory subunit 42	134	0.92
chr18_51150358_51150691	0.13	Prr16	proline rich 16	32786	0.23
chr1_23258293_23258464	0.13	Gm6420	predicted gene 6420	1971	0.22
chr5_86114424_86114626	0.13	Stap1	signal transducing adaptor family member 1	28067	0.13
chr14_62843293_62843448	0.13	Mir8098	microRNA 8098	5649	0.13
chr5_135776480_135776870	0.13	Styxl1	serine/threonine/tyrosine interacting-like 1	1563	0.22
chr1_60098880_60099160	0.13	Wdr12	WD repeat domain 12	375	0.68
chr3_24507903_24508125	0.13	Gm24704	predicted gene, 24704	54060	0.18
chr14_76901248_76901599	0.13	Gm48969	predicted gene, 48969	39852	0.15
chr17_64607771_64607970	0.13	Man2a1	mannosidase 2, alpha 1	7134	0.26
chr5_114589239_114589390	0.13	Fam222a	family with sequence similarity 222, member A	21297	0.14
chr19_34517768_34517926	0.13	Lipa	lysosomal acid lipase A	6867	0.14
chr4_57140481_57140705	0.13	Epb41l4b	erythrocyte membrane protein band 4.1 like 4b	2401	0.32
chr1_112947623_112947888	0.13	Gm28190	predicted gene 28190	19176	0.27
chr16_16990792_16991110	0.13	Mapk1	mitogen-activated protein kinase 1	7384	0.11
chr19_40153747_40153898	0.13	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	33464	0.13
chr1_105738205_105738360	0.13	Relch	RAB11 binding and LisH domain, coiled-coil and HEAT repeat containing	1930	0.29

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097167	circadian regulation of translation(GO:0097167)
0.1	0.2	GO:1904154	positive regulation of retrograde protein transport, ER to cytosol(GO:1904154)
0.1	0.2	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.1	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.1	GO:0002386	immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.0	0.1	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.0	0.1	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.0	0.1	GO:0018243	protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.1	GO:0010908	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.1	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.0	0.0	GO:0061724	lipophagy(GO:0061724)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0019086	late viral transcription(GO:0019086)
0.0	0.1	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.1	GO:0046449	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.1	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:0051661	maintenance of centrosome location(GO:0051661)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:0002051	osteoblast fate commitment(GO:0002051)
0.0	0.1	GO:0042737	drug catabolic process(GO:0042737)
0.0	0.1	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.1	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.0	GO:0061317	canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment(GO:0061317)
0.0	0.1	GO:1903333	negative regulation of protein folding(GO:1903333)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.1	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.1	GO:0060283	negative regulation of oocyte development(GO:0060283)
0.0	0.0	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.0	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:0051890	regulation of cardioblast differentiation(GO:0051890)
0.0	0.1	GO:0030638	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.1	GO:0006559	L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.1	GO:0030321	transepithelial chloride transport(GO:0030321)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.0	GO:2000809	positive regulation of synaptic vesicle clustering(GO:2000809)
0.0	0.0	GO:0071725	response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.0	0.0	GO:2001027	negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.0	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.0	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.1	GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.1	GO:0043653	mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0	0.1	GO:0000960	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.1	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.0	GO:0030050	vesicle transport along actin filament(GO:0030050)
0.0	0.1	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.0	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0043415	positive regulation of skeletal muscle tissue regeneration(GO:0043415)
0.0	0.0	GO:0051081	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:2000980	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.0	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.0	0.1	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.0	GO:0035694	mitochondrial protein catabolic process(GO:0035694)
0.0	0.1	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0	0.0	GO:0046149	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0060399	positive regulation of growth hormone receptor signaling pathway(GO:0060399)
0.0	0.1	GO:0051657	maintenance of organelle location(GO:0051657)
0.0	0.0	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.0	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.0	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.0	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.0	GO:0036015	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.1	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.0	GO:0060839	endothelial cell fate commitment(GO:0060839)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.0	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.0	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.0	GO:0090365	regulation of mRNA modification(GO:0090365)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.1	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0060020	Bergmann glial cell differentiation(GO:0060020)
0.0	0.1	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.0	0.0	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.0	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.1	GO:1902774	late endosome to lysosome transport(GO:1902774)
0.0	0.0	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.0	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.0	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.1	GO:0035838	growing cell tip(GO:0035838)
0.1	GO:0002177	manchette(GO:0002177)
0.1	GO:0070545	PeBoW complex(GO:0070545)
0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.1	GO:0097441	basilar dendrite(GO:0097441)
0.2	GO:0070852	cell body fiber(GO:0070852)
0.0	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.1	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.1	GO:0034715	pICln-Sm protein complex(GO:0034715)
0.1	GO:0045293	mRNA editing complex(GO:0045293)
0.0	GO:0071817	MMXD complex(GO:0071817)
0.1	GO:0030122	AP-2 adaptor complex(GO:0030122)
0.0	GO:0097454	Schwann cell microvillus(GO:0097454)
0.1	GO:0000808	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.2	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.3	GO:0003680	AT DNA binding(GO:0003680)
0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1	GO:0071553	uridine nucleotide receptor activity(GO:0015065) G-protein coupled pyrimidinergic nucleotide receptor activity(GO:0071553)
0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	GO:0038181	bile acid receptor activity(GO:0038181)
0.1	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.1	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	GO:0035276	ethanol binding(GO:0035276)
0.1	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.1	GO:0008494	translation activator activity(GO:0008494)
0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.1	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.1	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.1	GO:0015288	porin activity(GO:0015288)
0.1	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.1	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.3	GO:0008139	nuclear localization sequence binding(GO:0008139)
0.1	GO:0015643	toxic substance binding(GO:0015643)
0.1	GO:0097322	7SK snRNA binding(GO:0097322)
0.0	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1	GO:0004716	receptor signaling protein tyrosine kinase activity(GO:0004716)
0.0	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	GO:0005157	macrophage colony-stimulating factor receptor binding(GO:0005157)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.2	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism

Results for Lhx4

Z-value: 0.70

Motif logo

Transcription factors associated with Lhx4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Lhx4 motif across conditions

Conditions sorted by the z-value of the Lhx4 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: