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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Lhx5_Lmx1b_Lhx1

Z-value: 1.35

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Transcription factors associated with Lhx5_Lmx1b_Lhx1

Gene Symbol	Gene ID	Gene Info
Lhx5 Ensembl NCBI MGI UniProt	ENSMUSG00000029595.7	LIM homeobox protein 5
Lmx1b Ensembl NCBI MGI UniProt	ENSMUSG00000038765.7	LIM homeobox transcription factor 1 beta
Lhx1 Ensembl NCBI MGI UniProt	ENSMUSG00000018698.9	LIM homeobox protein 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr11_84522955_84523135	Lhx1	334	0.868084	0.70	1.2e-01	Click!
chr11_84523271_84523458	Lhx1	653	0.669544	0.63	1.8e-01	Click!
chr11_84523501_84523678	Lhx1	878	0.542340	0.49	3.3e-01	Click!
chr11_84522677_84522841	Lhx1	48	0.972621	0.45	3.7e-01	Click!
chr11_84523882_84524217	Lhx1	1338	0.356147	0.25	6.3e-01	Click!

Activity of the Lhx5_Lmx1b_Lhx1 motif across conditions

Conditions sorted by the z-value of the Lhx5_Lmx1b_Lhx1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr3_60495047_60495368	0.91	Mbnl1	muscleblind like splicing factor 1	5728	0.26
chr16_84807428_84807749	0.82	Jam2	junction adhesion molecule 2	1819	0.26
chr2_34049474_34049625	0.81	C230014O12Rik	RIKEN cDNA C230014O12 gene	58180	0.11
chr19_31886956_31887132	0.77	A1cf	APOBEC1 complementation factor	18263	0.2
chr10_125785978_125786129	0.73	Lrig3	leucine-rich repeats and immunoglobulin-like domains 3	180115	0.03
chr14_30530847_30531018	0.67	Dcp1a	decapping mRNA 1A	7225	0.15
chr1_73954752_73954963	0.67	Tns1	tensin 1	8186	0.24
chr2_127608341_127608498	0.63	Mrps5	mitochondrial ribosomal protein S5	8386	0.13
chr9_15301981_15302132	0.61	4931406C07Rik	RIKEN cDNA 4931406C07 gene	500	0.46
chr10_28178649_28178847	0.60	Gm22370	predicted gene, 22370	35373	0.21
chr11_90184166_90184514	0.59	n-R5s72	nuclear encoded rRNA 5S 72	787	0.57
chr3_157024330_157024498	0.58	Gm43527	predicted gene 43527	23997	0.2
chr9_106264996_106265377	0.58	Poc1a	POC1 centriolar protein A	15875	0.1
chr10_37324159_37324310	0.58	Gm26535	predicted gene, 26535	13252	0.25
chr3_69115488_69115663	0.57	Gm37558	predicted gene, 37558	7149	0.14
chr11_21121403_21121623	0.56	Peli1	pellino 1	13956	0.18
chr12_55420887_55421038	0.55	Psma6	proteasome subunit alpha 6	13579	0.16
chr19_48883437_48883771	0.55	Gm50436	predicted gene, 50436	72468	0.11
chr13_5229559_5229735	0.54	Gm47451	predicted gene, 47451	13469	0.25
chr4_63738674_63738850	0.52	Tnfsf15	tumor necrosis factor (ligand) superfamily, member 15	6351	0.22
chr6_100267052_100267222	0.51	Gm44044	predicted gene, 44044	6561	0.17
chr5_92607049_92607221	0.51	Stbd1	starch binding domain 1	4067	0.19
chr13_117745874_117746186	0.50	4933413L06Rik	RIKEN cDNA 4933413L06 gene	26019	0.26
chr12_73341772_73342027	0.49	Slc38a6	solute carrier family 38, member 6	2468	0.25
chr11_98339208_98339359	0.49	Ppp1r1b	protein phosphatase 1, regulatory inhibitor subunit 1B	9121	0.09
chr19_7500165_7500363	0.48	Atl3	atlastin GTPase 3	5729	0.15
chr3_10211563_10211714	0.46	Fabp4	fatty acid binding protein 4, adipocyte	3062	0.13
chr11_111605518_111605669	0.45	Gm11676	predicted gene 11676	7713	0.32
chr14_64444658_64444809	0.45	Msra	methionine sulfoxide reductase A	3816	0.31
chr7_45480279_45480444	0.45	Dhdh	dihydrodiol dehydrogenase (dimeric)	430	0.52
chr19_32544319_32544470	0.43	Gm36419	predicted gene, 36419	1046	0.53
chr19_27328502_27328670	0.43	Kcnv2	potassium channel, subfamily V, member 2	5998	0.19
chr9_54139319_54139478	0.43	Cyp19a1	cytochrome P450, family 19, subfamily a, polypeptide 1	42676	0.14
chr2_76970830_76970996	0.43	Ttn	titin	9269	0.25
chr2_75605802_75605972	0.42	Gm13655	predicted gene 13655	27495	0.15
chr17_32257244_32257401	0.42	Brd4	bromodomain containing 4	15043	0.12
chr5_99976807_99976958	0.42	Hnrnpd	heterogeneous nuclear ribonucleoprotein D	331	0.73
chr12_4844936_4845087	0.41	Wdcp	WD repeat and coiled coil containing	1617	0.23
chr9_20504907_20505058	0.41	Zfp426	zinc finger protein 426	12236	0.11
chr1_39133288_39133558	0.41	Gm37091	predicted gene, 37091	50085	0.11
chr14_100201613_100201764	0.41	4930517O19Rik	RIKEN cDNA 4930517O19 gene	11454	0.2
chr17_13821264_13821648	0.40	Afdn	afadin, adherens junction formation factor	29506	0.14
chr1_9968620_9968771	0.40	Tcf24	transcription factor 24	763	0.41
chr2_155378239_155378390	0.40	Trp53inp2	transformation related protein 53 inducible nuclear protein 2	2745	0.19
chr14_62736570_62736721	0.40	Ints6	integrator complex subunit 6	24467	0.14
chr18_10461512_10461756	0.40	Greb1l	growth regulation by estrogen in breast cancer-like	3409	0.24
chr13_104035617_104035778	0.39	Nln	neurolysin (metallopeptidase M3 family)	870	0.63
chr7_115674458_115674622	0.38	Sox6	SRY (sex determining region Y)-box 6	12175	0.3
chr6_146730929_146731080	0.38	Stk38l	serine/threonine kinase 38 like	5692	0.17
chr4_123419684_123419835	0.37	Macf1	microtubule-actin crosslinking factor 1	7531	0.17
chr18_5013827_5013978	0.37	Svil	supervillin	18966	0.27
chr19_60570173_60570324	0.37	Gm25238	predicted gene, 25238	10281	0.18
chr2_73276147_73276506	0.37	Sp9	trans-acting transcription factor 9	4360	0.18
chr1_90915370_90915560	0.36	Mlph	melanophilin	380	0.84
chr4_35101216_35101367	0.36	Ifnk	interferon kappa	50765	0.12
chr17_42859720_42859889	0.36	Cd2ap	CD2-associated protein	16585	0.26
chr12_51348476_51348659	0.35	G2e3	G2/M-phase specific E3 ubiquitin ligase	195	0.95
chr1_172700535_172700739	0.35	Crp	C-reactive protein, pentraxin-related	2581	0.25
chr16_43014052_43014241	0.35	Ndufs5-ps	NADH:ubiquinone oxidoreductase core subunit S5, pseudogene	58515	0.13
chr13_34555664_34555830	0.35	Gm36758	predicted gene, 36758	6239	0.19
chr6_28587807_28587958	0.35	Gm37978	predicted gene, 37978	19810	0.16
chr13_104044189_104044340	0.35	Nln	neurolysin (metallopeptidase M3 family)	6622	0.22
chr1_112947623_112947888	0.35	Gm28190	predicted gene 28190	19176	0.27
chr16_27403508_27403659	0.35	Ccdc50	coiled-coil domain containing 50	13615	0.21
chr19_60812093_60812292	0.35	Fam45a	family with sequence similarity 45, member A	152	0.92
chr11_77770194_77770550	0.34	Myo18a	myosin XVIIIA	1779	0.27
chr15_77251530_77251759	0.34	Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	6058	0.17
chr14_21095037_21095192	0.34	Adk	adenosine kinase	18962	0.21
chr3_79379701_79379957	0.34	Gm17359	predicted gene, 17359	34450	0.17
chr8_33905969_33906196	0.33	Rbpms	RNA binding protein gene with multiple splicing	14318	0.16
chr16_37606843_37607024	0.33	Gm46559	predicted gene, 46559	10743	0.15
chr10_59521015_59521234	0.33	Mcu	mitochondrial calcium uniporter	62964	0.1
chr3_131485378_131485553	0.33	Sgms2	sphingomyelin synthase 2	5014	0.28
chr11_121550191_121550342	0.33	Tbcd	tubulin-specific chaperone d	155	0.96
chr2_62386509_62386700	0.32	Dpp4	dipeptidylpeptidase 4	8356	0.19
chr7_24600475_24600626	0.32	Phldb3	pleckstrin homology like domain, family B, member 3	10213	0.08
chr6_141634890_141635041	0.32	Slco1b2	solute carrier organic anion transporter family, member 1b2	507	0.86
chr10_87868820_87868971	0.32	Igf1os	insulin-like growth factor 1, opposite strand	5514	0.22
chr19_55111923_55112097	0.32	Gpam	glycerol-3-phosphate acyltransferase, mitochondrial	8919	0.2
chr5_138080510_138080792	0.32	Zkscan1	zinc finger with KRAB and SCAN domains 1	4433	0.1
chr4_63773592_63773743	0.32	Tnfsf15	tumor necrosis factor (ligand) superfamily, member 15	28554	0.18
chr2_72309170_72309345	0.32	Map3k20	mitogen-activated protein kinase kinase kinase 20	11356	0.19
chr1_119646750_119646988	0.32	Epb41l5	erythrocyte membrane protein band 4.1 like 5	1748	0.32
chr16_37530514_37530882	0.31	Gtf2e1	general transcription factor II E, polypeptide 1 (alpha subunit)	9078	0.16
chr1_21315523_21315674	0.31	Gm21909	predicted gene, 21909	722	0.5
chr11_106583145_106583311	0.31	Tex2	testis expressed gene 2	2628	0.28
chr12_12940858_12941058	0.31	Mycn	v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived	342	0.83
chr3_133042582_133042733	0.31	Gm42874	predicted gene 42874	9738	0.14
chr17_84990758_84990958	0.31	Ppm1b	protein phosphatase 1B, magnesium dependent, beta isoform	2815	0.25
chr18_12202319_12202472	0.31	Npc1	NPC intracellular cholesterol transporter 1	6988	0.14
chr13_28718314_28718531	0.31	Mir6368	microRNA 6368	7549	0.28
chr6_101095542_101095693	0.30	Gm43948	predicted gene, 43948	36446	0.13
chr12_79404609_79405013	0.30	Rad51b	RAD51 paralog B	77458	0.1
chr10_12645976_12646209	0.30	Utrn	utrophin	31261	0.22
chr5_129669529_129669717	0.30	Zfp11	zinc finger protein 11	476	0.73
chr6_8862762_8862913	0.30	Ica1	islet cell autoantigen 1	84349	0.1
chr11_111067244_111067395	0.30	Kcnj2	potassium inwardly-rectifying channel, subfamily J, member 2	1155	0.62
chr12_3811591_3811763	0.30	Dnmt3a	DNA methyltransferase 3A	4517	0.2
chr5_123975512_123975863	0.30	Hip1r	huntingtin interacting protein 1 related	2059	0.19
chr6_108836766_108836917	0.30	Edem1	ER degradation enhancer, mannosidase alpha-like 1	431	0.86
chr4_57160943_57161117	0.29	Gm12530	predicted gene 12530	11041	0.2
chr15_25942169_25942359	0.29	Retreg1	reticulophagy regulator 1	415	0.85
chr4_87899011_87899212	0.29	Mllt3	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	24569	0.24
chr7_118151770_118151921	0.29	Gm25683	predicted gene, 25683	1635	0.32
chr9_46479855_46480133	0.29	Gm47144	predicted gene, 47144	25079	0.15
chr11_80247133_80247304	0.29	Rhot1	ras homolog family member T1	2456	0.28
chr19_37507552_37507703	0.29	Exoc6	exocyst complex component 6	13252	0.16
chr12_103388315_103388482	0.29	Otub2	OTU domain, ubiquitin aldehyde binding 2	284	0.82
chr2_115449849_115450246	0.29	3110099E03Rik	RIKEN cDNA 3110099E03 gene	62154	0.12
chr12_78266965_78267134	0.29	Gm48225	predicted gene, 48225	5756	0.17
chr14_114517521_114517864	0.29	Gm19829	predicted gene, 19829	206889	0.02
chr1_84132307_84132510	0.29	Gm37058	predicted gene, 37058	2102	0.37
chr17_50370553_50370865	0.29	Gm49906	predicted gene, 49906	31457	0.19
chr5_135776480_135776870	0.29	Styxl1	serine/threonine/tyrosine interacting-like 1	1563	0.22
chr2_124852123_124852274	0.29	Gm13994	predicted gene 13994	143543	0.04
chr9_121353230_121353406	0.28	Gm47092	predicted gene, 47092	6762	0.17
chr14_21599276_21599451	0.28	Kat6b	K(lysine) acetyltransferase 6B	23179	0.21
chr10_117123042_117123236	0.28	Frs2	fibroblast growth factor receptor substrate 2	7707	0.15
chr18_38524013_38524201	0.28	Gm50349	predicted gene, 50349	42804	0.11
chr10_89502299_89502578	0.28	Nr1h4	nuclear receptor subfamily 1, group H, member 4	4211	0.26
chr2_67956563_67957019	0.28	Gm37964	predicted gene, 37964	58195	0.14
chr4_40698726_40698877	0.28	Aptx	aprataxin	3915	0.15
chr16_90266479_90266654	0.28	Scaf4	SR-related CTD-associated factor 4	7766	0.17
chr11_75734405_75734749	0.28	Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	1429	0.37
chr7_123124873_123125354	0.28	Tnrc6a	trinucleotide repeat containing 6a	857	0.66
chr5_22506386_22506555	0.27	Orc5	origin recognition complex, subunit 5	16196	0.12
chr3_63413482_63413662	0.27	Gm34240	predicted gene, 34240	25679	0.19
chr14_8035648_8035848	0.27	Abhd6	abhydrolase domain containing 6	32782	0.13
chr18_64619314_64619465	0.27	Gm6978	predicted gene 6978	6290	0.17
chr11_120186847_120187216	0.27	2810410L24Rik	RIKEN cDNA 2810410L24 gene	1720	0.22
chr17_88614606_88614762	0.27	Gm9406	predicted gene 9406	6140	0.17
chr14_21165960_21166111	0.27	Adk	adenosine kinase	89883	0.08
chr13_115653702_115653853	0.26	Gm47892	predicted gene, 47892	65722	0.13
chr14_27402254_27402522	0.26	Gm23633	predicted gene, 23633	21538	0.16
chr8_34506104_34506386	0.26	Gm8268	predicted gene 8268	962	0.54
chr15_88205866_88206049	0.26	B230214G05Rik	RIKEN cDNA B230214G05 gene	108917	0.07
chr16_94606252_94606403	0.26	Gm15971	predicted gene 15971	14050	0.19
chr1_88764125_88764295	0.26	Platr5	pluripotency associated transcript 5	9256	0.2
chrX_85856039_85856199	0.26	5430427O19Rik	RIKEN cDNA 5430427O19 gene	14235	0.16
chr8_89407033_89407242	0.26	Gm26331	predicted gene, 26331	182404	0.03
chr8_93223476_93223647	0.26	Ces1e	carboxylesterase 1E	4129	0.16
chr15_39870011_39870207	0.26	Dpys	dihydropyrimidinase	12639	0.21
chr19_36629275_36629447	0.26	Hectd2os	Hectd2, opposite strand	3337	0.28
chr15_16844404_16844562	0.26	Gm49127	predicted gene, 49127	6481	0.3
chr11_88618341_88618520	0.26	Msi2	musashi RNA-binding protein 2	28283	0.2
chr5_87124253_87124404	0.26	Gm42795	predicted gene 42795	9719	0.12
chr10_100031523_100031679	0.25	Kitl	kit ligand	15685	0.19
chr9_118689127_118689278	0.25	Itga9	integrin alpha 9	3367	0.3
chr17_10187170_10187336	0.25	Qk	quaking	26321	0.25
chr18_11614667_11614838	0.25	Gm50067	predicted gene, 50067	10163	0.2
chr15_55823868_55824092	0.25	Sntb1	syntrophin, basic 1	82330	0.08
chr13_16760766_16760929	0.25	Gm7537	predicted gene 7537	121357	0.06
chr18_68292618_68292974	0.25	Fam210a	family with sequence similarity 210, member A	7406	0.16
chr14_67900348_67900512	0.25	Dock5	dedicator of cytokinesis 5	33002	0.17
chr1_131465972_131466299	0.25	Gm29487	predicted gene 29487	18440	0.14
chr19_34852544_34852695	0.25	Pank1	pantothenate kinase 1	25230	0.13
chr17_24818767_24819039	0.25	Meiob	meiosis specific with OB domains	14544	0.08
chr6_51456047_51456211	0.25	Hnrnpa2b1	heterogeneous nuclear ribonucleoprotein A2/B1	7055	0.17
chr7_71419354_71419520	0.25	Gm29328	predicted gene 29328	49104	0.14
chr7_49764294_49764503	0.25	Htatip2	HIV-1 Tat interactive protein 2	5245	0.23
chr9_112123334_112123526	0.25	Mir128-2	microRNA 128-2	4719	0.29
chr11_88277047_88277211	0.25	Ccdc182	coiled-coil domain containing 182	16929	0.15
chr14_27897472_27897637	0.25	Erc2	ELKS/RAB6-interacting/CAST family member 2	21140	0.22
chr8_93397874_93398136	0.25	Gm45764	predicted gene 45764	900	0.48
chr13_93889949_93890100	0.25	Gm25534	predicted gene, 25534	33287	0.15
chr14_52196558_52196748	0.25	Supt16	SPT16, facilitates chromatin remodeling subunit	763	0.35
chr7_68285442_68285612	0.24	Gm16157	predicted gene 16157	8933	0.14
chr12_34238298_34238489	0.24	Gm18025	predicted gene, 18025	52742	0.18
chr6_122148793_122148971	0.24	Gm10319	predicted pseudogene 10319	12150	0.17
chr13_101016552_101016703	0.24	Gm6114	predicted gene 6114	2641	0.28
chr4_134130965_134131164	0.24	Cep85	centrosomal protein 85	1578	0.21
chr5_66054307_66054470	0.24	Rbm47	RNA binding motif protein 47	164	0.93
chr15_102191817_102192017	0.24	Csad	cysteine sulfinic acid decarboxylase	142	0.92
chr10_22004298_22004461	0.24	Sgk1	serum/glucocorticoid regulated kinase 1	7788	0.15
chr16_95141689_95141853	0.24	Gm49642	predicted gene, 49642	29739	0.18
chr12_8641402_8641553	0.24	Pum2	pumilio RNA-binding family member 2	32657	0.16
chr3_14787462_14787685	0.24	Car1	carbonic anhydrase 1	9114	0.18
chr1_131504400_131504768	0.24	Srgap2	SLIT-ROBO Rho GTPase activating protein 2	218	0.91
chr8_109803384_109803547	0.23	Ap1g1	adaptor protein complex AP-1, gamma 1 subunit	24559	0.12
chr18_60385124_60385313	0.23	Iigp1	interferon inducible GTPase 1	2535	0.22
chr19_56336755_56336948	0.23	Habp2	hyaluronic acid binding protein 2	23903	0.15
chr12_40561876_40562268	0.23	Dock4	dedicator of cytokinesis 4	115736	0.06
chr10_92231237_92231404	0.23	Gm8512	predicted gene 8512	7846	0.21
chr13_60267432_60267612	0.23	Gm24999	predicted gene, 24999	26150	0.16
chr9_68809615_68809769	0.23	Rora	RAR-related orphan receptor alpha	154389	0.04
chr3_85265616_85265908	0.23	1700036G14Rik	RIKEN cDNA 1700036G14 gene	51757	0.14
chr5_86114424_86114626	0.23	Stap1	signal transducing adaptor family member 1	28067	0.13
chr4_126764112_126764263	0.23	AU040320	expressed sequence AU040320	10361	0.13
chr3_108496483_108496708	0.23	Gm23336	predicted gene, 23336	1523	0.23
chr7_71467703_71467871	0.23	Gm29328	predicted gene 29328	97454	0.07
chr4_124809297_124809476	0.23	Mtf1	metal response element binding transcription factor 1	6708	0.1
chr6_72120521_72121047	0.23	4933431G14Rik	RIKEN cDNA 4933431G14 gene	2156	0.2
chr17_64607771_64607970	0.23	Man2a1	mannosidase 2, alpha 1	7134	0.26
chr14_45487800_45488006	0.23	Fermt2	fermitin family member 2	3934	0.14
chr1_160996279_160996443	0.23	Gm37072	predicted gene, 37072	5484	0.07
chr7_75467233_75467387	0.23	Akap13	A kinase (PRKA) anchor protein 13	11442	0.16
chr13_31779124_31779297	0.23	Gm11379	predicted gene 11379	18329	0.16
chr18_3465417_3465568	0.23	Gm50088	predicted gene, 50088	1010	0.43
chr11_60782796_60782947	0.23	Smcr8	Smith-Magenis syndrome chromosome region, candidate 8 homolog (human)	5346	0.09
chr11_53418931_53419109	0.22	Leap2	liver-expressed antimicrobial peptide 2	4150	0.1

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx5_Lmx1b_Lhx1

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	0.3	GO:0045472	response to ether(GO:0045472)
0.1	0.3	GO:1904380	endoplasmic reticulum mannose trimming(GO:1904380)
0.1	0.3	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.1	0.3	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.1	0.2	GO:0042732	D-xylose metabolic process(GO:0042732)
0.1	0.2	GO:0046439	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.1	0.2	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.2	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.1	0.2	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1	0.2	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.1	0.2	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.2	GO:0003383	apical constriction(GO:0003383)
0.0	0.2	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0030241	skeletal muscle myosin thick filament assembly(GO:0030241) striated muscle myosin thick filament assembly(GO:0071688)
0.0	0.2	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.2	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0061724	lipophagy(GO:0061724)
0.0	0.2	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.2	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.2	GO:1902035	positive regulation of hematopoietic stem cell proliferation(GO:1902035)
0.0	0.1	GO:0014834	skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834)
0.0	0.1	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.1	GO:0010909	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.1	GO:0006208	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.1	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.1	GO:1904339	negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0	0.1	GO:0006808	regulation of nitrogen utilization(GO:0006808)
0.0	0.3	GO:0045607	regulation of auditory receptor cell differentiation(GO:0045607) regulation of mechanoreceptor differentiation(GO:0045631) regulation of inner ear receptor cell differentiation(GO:2000980)
0.0	0.1	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.1	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.2	GO:0086013	membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0014045	establishment of endothelial blood-brain barrier(GO:0014045)
0.0	0.1	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.2	GO:0035871	protein K11-linked deubiquitination(GO:0035871)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.0	0.1	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.1	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	0.1	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.0	0.1	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.0	0.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.1	GO:0051661	maintenance of centrosome location(GO:0051661)
0.0	0.2	GO:0051409	response to nitrosative stress(GO:0051409)
0.0	0.1	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0003331	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0	0.1	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.1	GO:0006499	N-terminal protein myristoylation(GO:0006499)
0.0	0.0	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.0	0.1	GO:0034499	late endosome to Golgi transport(GO:0034499)
0.0	0.2	GO:2001223	negative regulation of neuron migration(GO:2001223)
0.0	0.1	GO:1990168	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.1	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0051790	short-chain fatty acid biosynthetic process(GO:0051790)
0.0	0.1	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.1	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.1	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.1	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.0	GO:0035962	response to interleukin-13(GO:0035962) cellular response to interleukin-13(GO:0035963)
0.0	0.2	GO:0055091	phospholipid homeostasis(GO:0055091)
0.0	0.1	GO:1900246	positive regulation of RIG-I signaling pathway(GO:1900246)
0.0	0.1	GO:0072095	regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.0	0.1	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.1	GO:0090296	regulation of mitochondrial DNA replication(GO:0090296)
0.0	0.0	GO:0044860	protein localization to plasma membrane raft(GO:0044860)
0.0	0.1	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:0071727	response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.0	0.0	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0	0.0	GO:0070103	regulation of interleukin-6-mediated signaling pathway(GO:0070103)
0.0	0.1	GO:2000860	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.0	0.1	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.1	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.0	GO:0060842	arterial endothelial cell differentiation(GO:0060842)
0.0	0.1	GO:0018243	protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.1	GO:0019919	peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.0	0.0	GO:0009804	coumarin metabolic process(GO:0009804)
0.0	0.1	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.2	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0021684	cerebellar granular layer formation(GO:0021684) cerebellar granule cell differentiation(GO:0021707)
0.0	0.1	GO:0061010	gall bladder development(GO:0061010)
0.0	0.0	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.1	GO:0045896	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:2000562	negative regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000562)
0.0	0.0	GO:0048022	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0	0.1	GO:0034139	regulation of toll-like receptor 3 signaling pathway(GO:0034139)
0.0	0.1	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.0	GO:0000720	pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.0	0.1	GO:0043622	cortical microtubule organization(GO:0043622)
0.0	0.1	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.1	GO:0006931	substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.0	GO:0070350	white fat cell proliferation(GO:0070343) regulation of white fat cell proliferation(GO:0070350)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.1	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.1	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.1	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.0	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.1	GO:0045653	negative regulation of megakaryocyte differentiation(GO:0045653)
0.0	0.0	GO:0003223	ventricular compact myocardium morphogenesis(GO:0003223)
0.0	0.1	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:0051775	response to redox state(GO:0051775)
0.0	0.1	GO:0060267	positive regulation of respiratory burst(GO:0060267)
0.0	0.0	GO:0032788	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.0	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.1	GO:0097066	response to thyroid hormone(GO:0097066)
0.0	0.1	GO:1901409	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.3	GO:0032400	melanosome localization(GO:0032400)
0.0	0.1	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.1	GO:0090161	Golgi ribbon formation(GO:0090161)
0.0	0.1	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.1	GO:0000012	single strand break repair(GO:0000012)
0.0	0.0	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.0	GO:0097195	pilomotor reflex(GO:0097195)
0.0	0.0	GO:2000828	regulation of parathyroid hormone secretion(GO:2000828)
0.0	0.2	GO:0010971	positive regulation of G2/M transition of mitotic cell cycle(GO:0010971)
0.0	0.0	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.0	0.0	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.0	0.1	GO:0001302	replicative cell aging(GO:0001302)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0032439	endosome localization(GO:0032439)
0.0	0.0	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.0	0.1	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.0	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.0	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.1	GO:1904354	negative regulation of telomere capping(GO:1904354)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.1	GO:0015816	glycine transport(GO:0015816)
0.0	0.1	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.1	GO:0060696	regulation of phospholipid catabolic process(GO:0060696)
0.0	0.1	GO:0006572	tyrosine catabolic process(GO:0006572)
0.0	0.0	GO:2000302	positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.0	0.0	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0090520	sphingolipid mediated signaling pathway(GO:0090520)
0.0	0.1	GO:0010756	positive regulation of plasminogen activation(GO:0010756)
0.0	0.1	GO:0033578	protein glycosylation in Golgi(GO:0033578)
0.0	0.0	GO:0061209	cell proliferation involved in mesonephros development(GO:0061209)
0.0	0.0	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.0	GO:1901491	negative regulation of lymphangiogenesis(GO:1901491)
0.0	0.1	GO:0032324	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.0	GO:0060596	mammary placode formation(GO:0060596)
0.0	0.0	GO:0030951	establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
0.0	0.1	GO:0032534	regulation of microvillus assembly(GO:0032534)
0.0	0.1	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.0	0.0	GO:0048021	regulation of melanin biosynthetic process(GO:0048021) regulation of secondary metabolite biosynthetic process(GO:1900376)
0.0	0.0	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.0	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.0	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.1	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.0	GO:0046449	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.0	0.0	GO:0070427	nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
0.0	0.1	GO:0001842	neural fold formation(GO:0001842)
0.0	0.0	GO:0036265	RNA (guanine-N7)-methylation(GO:0036265)
0.0	0.1	GO:0033631	cell-cell adhesion mediated by integrin(GO:0033631)
0.0	0.0	GO:0030242	pexophagy(GO:0030242)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.0	GO:0046874	quinolinate metabolic process(GO:0046874)
0.0	0.0	GO:0002322	B cell proliferation involved in immune response(GO:0002322)
0.0	0.3	GO:0046834	lipid phosphorylation(GO:0046834)
0.0	0.0	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.2	GO:0001967	suckling behavior(GO:0001967)
0.0	0.0	GO:0071798	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	0.1	GO:0010992	ubiquitin homeostasis(GO:0010992)
0.0	0.2	GO:0010569	regulation of double-strand break repair via homologous recombination(GO:0010569)
0.0	0.1	GO:0051382	kinetochore assembly(GO:0051382)
0.0	0.0	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.1	GO:0042737	drug catabolic process(GO:0042737)
0.0	0.0	GO:0071830	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.0	GO:0035622	intrahepatic bile duct development(GO:0035622)
0.0	0.0	GO:0051081	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.1	GO:0045116	protein neddylation(GO:0045116)
0.0	0.1	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0	0.0	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0045293	mRNA editing complex(GO:0045293)
0.3	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.1	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.1	GO:0032437	cuticular plate(GO:0032437)
0.2	GO:0044327	dendritic spine head(GO:0044327)
0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.2	GO:0019773	proteasome core complex, alpha-subunit complex(GO:0019773)
0.1	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.1	GO:0005784	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.3	GO:0035371	microtubule plus-end(GO:0035371)
0.1	GO:0000938	GARP complex(GO:0000938)
0.1	GO:1990909	Wnt signalosome(GO:1990909)
0.1	GO:0043219	lateral loop(GO:0043219)
0.1	GO:0097255	R2TP complex(GO:0097255)
0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.1	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	GO:0097441	basilar dendrite(GO:0097441)
0.0	GO:0005896	interleukin-6 receptor complex(GO:0005896)
0.0	GO:0035838	growing cell tip(GO:0035838)
0.1	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.0	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.1	GO:0005579	membrane attack complex(GO:0005579)
0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	GO:0044611	nuclear pore inner ring(GO:0044611)
0.1	GO:0005859	muscle myosin complex(GO:0005859)
0.0	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.2	GO:0043034	costamere(GO:0043034)
0.0	GO:0030891	VCB complex(GO:0030891)
0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.1	GO:0097431	mitotic spindle pole(GO:0097431)
0.1	GO:1990023	mitotic spindle midzone(GO:1990023)
0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0001069	regulatory region RNA binding(GO:0001069)
0.1	0.3	GO:0019784	NEDD8-specific protease activity(GO:0019784)
0.1	0.2	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.3	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.2	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.2	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:0070905	serine binding(GO:0070905)
0.0	0.2	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.1	GO:2001069	glycogen binding(GO:2001069)
0.0	0.0	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.1	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	0.2	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.2	GO:0004301	epoxide hydrolase activity(GO:0004301)
0.0	0.1	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.0	0.1	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0	0.1	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0070728	leucine binding(GO:0070728)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.3	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.2	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.2	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:0019770	IgG receptor activity(GO:0019770)
0.0	0.2	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.1	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.1	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
0.0	0.1	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0002054	nucleobase binding(GO:0002054)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.1	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.1	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.2	GO:0070180	large ribosomal subunit rRNA binding(GO:0070180)
0.0	0.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.1	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	0.1	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.0	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	0.0	GO:0005483	soluble NSF attachment protein activity(GO:0005483)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0031852	mu-type opioid receptor binding(GO:0031852)
0.0	0.0	GO:0052658	inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658)
0.0	0.0	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.0	GO:0016508	long-chain-enoyl-CoA hydratase activity(GO:0016508)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.0	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
0.0	0.1	GO:0070878	primary miRNA binding(GO:0070878)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.0	0.3	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.0	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.0	GO:0019961	interferon binding(GO:0019961)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.1	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.0	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.0	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.0	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.2	GO:0070016	armadillo repeat domain binding(GO:0070016)
0.0	0.0	GO:1901612	cardiolipin binding(GO:1901612)
0.0	0.0	GO:0102345	3-hydroxyacyl-CoA dehydratase activity(GO:0018812) 3-hydroxy-behenoyl-CoA dehydratase activity(GO:0102344) 3-hydroxy-lignoceroyl-CoA dehydratase activity(GO:0102345)
0.0	0.1	GO:0097602	cullin family protein binding(GO:0097602)
0.0	0.2	GO:0005123	death receptor binding(GO:0005123)
0.0	0.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.0	0.0	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.0	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0048156	tau protein binding(GO:0048156)
0.0	0.0	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.0	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.4	GO:0048487	beta-tubulin binding(GO:0048487)
0.0	0.0	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0	0.1	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0008494	translation activator activity(GO:0008494)
0.0	0.0	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	0.0	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0	0.1	GO:0035242	protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.4	GO:0048365	Rac GTPase binding(GO:0048365)
0.0	0.0	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.0	0.0	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.2	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	PID DNA PK PATHWAY	DNA-PK pathway in nonhomologous end joining
0.1	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.1	PID ARF6 PATHWAY	Arf6 signaling events
0.2	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.3	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.2	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.2	REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX	Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.1	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.1	REACTOME BETA DEFENSINS	Genes involved in Beta defensins
0.1	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1	Genes involved in Regulation of AMPK activity via LKB1
0.5	REACTOME DESTABILIZATION OF MRNA BY AUF1 HNRNP D0	Genes involved in Destabilization of mRNA by AUF1 (hnRNP D0)

Results for Lhx5_Lmx1b_Lhx1

Z-value: 1.35

Motif logo

Transcription factors associated with Lhx5_Lmx1b_Lhx1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Lhx5_Lmx1b_Lhx1 motif across conditions

Conditions sorted by the z-value of the Lhx5_Lmx1b_Lhx1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Lhx5_Lmx1b_Lhx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: