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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Mafa

Z-value: 0.93

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Transcription factors associated with Mafa

Gene Symbol	Gene ID	Gene Info
Mafa Ensembl NCBI MGI UniProt	ENSMUSG00000047591.4	Mafa

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Mafa	chr15_75748699_75748884	563	0.657377	-0.76	8.1e-02	Click!
Mafa	chr15_75748359_75748528	215	0.899459	-0.57	2.4e-01	Click!
Mafa	chr15_75748161_75748312	8	0.964253	-0.52	2.9e-01	Click!

Activity of the Mafa motif across conditions

Conditions sorted by the z-value of the Mafa motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr15_27466172_27467167	0.52	Ank	progressive ankylosis	8	0.97
chr11_4378478_4378660	0.51	Hormad2	HORMA domain containing 2	48693	0.1
chr17_46052256_46052407	0.48	Vegfa	vascular endothelial growth factor A	19962	0.13
chr13_45717276_45717427	0.42	Gm47460	predicted gene, 47460	32221	0.22
chr19_40155227_40155577	0.38	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	31884	0.13
chr3_52649145_52649332	0.37	Gm10293	predicted pseudogene 10293	36403	0.17
chr8_69090324_69090475	0.37	Slc18a1	solute carrier family 18 (vesicular monoamine), member 1	1164	0.38
chr2_44113422_44113573	0.36	Arhgap15os	Rho GTPase activating protein 15, opposite strand	48173	0.17
chr17_28761439_28761590	0.35	Mapk13	mitogen-activated protein kinase 13	7783	0.12
chr11_82527093_82527250	0.34	Gm24612	predicted gene, 24612	69008	0.09
chr11_83721035_83721187	0.34	Wfdc18	WAP four-disulfide core domain 18	11986	0.08
chr5_53278040_53278387	0.34	Smim20	small integral membrane protein 20	1095	0.48
chr2_153444307_153444698	0.33	Nol4l	nucleolar protein 4-like	23	0.98
chr19_4493105_4493260	0.33	2010003K11Rik	RIKEN cDNA 2010003K11 gene	5401	0.13
chr7_90099485_90099651	0.32	Gm5341	predicted pseudogene 5341	8400	0.13
chrX_36823954_36824173	0.32	Gm14549	predicted gene 14549	9292	0.12
chr5_122320451_122320627	0.32	Gm15842	predicted gene 15842	18117	0.09
chr17_8769269_8769442	0.31	Gm15426	predicted gene 15426	3428	0.29
chr17_25127135_25127453	0.31	Clcn7	chloride channel, voltage-sensitive 7	6097	0.1
chr19_16437834_16438025	0.30	Gna14	guanine nucleotide binding protein, alpha 14	1371	0.4
chr3_52531720_52531871	0.30	Gm30173	predicted gene, 30173	14831	0.23
chr13_63293654_63293805	0.28	Aopep	aminopeptidase O	5064	0.09
chr6_51325666_51325826	0.28	Gm32479	predicted gene, 32479	37891	0.14
chr6_90568297_90568448	0.27	Aldh1l1	aldehyde dehydrogenase 1 family, member L1	666	0.63
chr4_108362975_108363166	0.27	Shisal2a	shisa like 2A	20279	0.11
chr13_112331307_112331468	0.27	Ankrd55	ankyrin repeat domain 55	12933	0.17
chr15_61098917_61099257	0.27	Gm38563	predicted gene, 38563	58782	0.13
chr6_144709069_144709350	0.26	Sox5os4	SRY (sex determining region Y)-box 5, opposite strand 4	11702	0.16
chr2_165442563_165442717	0.26	Gm14437	predicted gene 14437	376	0.82
chr1_131278227_131278383	0.26	Ikbke	inhibitor of kappaB kinase epsilon	1301	0.32
chr5_129846397_129846548	0.24	Sumf2	sulfatase modifying factor 2	514	0.59
chr9_94705415_94705619	0.24	Gm16262	predicted gene 16262	3198	0.23
chr17_81389463_81389664	0.23	Gm50044	predicted gene, 50044	18730	0.23
chr3_51251932_51252083	0.23	Elf2	E74-like factor 2	8234	0.13
chr7_27452561_27452934	0.23	Blvrb	biliverdin reductase B (flavin reductase (NADPH))	303	0.79
chr1_88702033_88702468	0.22	Arl4c	ADP-ribosylation factor-like 4C	29	0.97
chr1_21247881_21248070	0.22	Gsta3	glutathione S-transferase, alpha 3	5546	0.12
chr2_52580732_52580891	0.22	Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	22244	0.17
chr3_51231004_51231169	0.22	Gm38357	predicted gene, 38357	831	0.53
chr14_86346221_86346400	0.22	Gm4350	predicted gene 4350	26025	0.13
chr3_27562067_27562227	0.22	Gm43344	predicted gene 43344	15506	0.22
chr8_126928052_126928350	0.21	Gm26397	predicted gene, 26397	16779	0.14
chr18_32271671_32271889	0.21	Ercc3	excision repair cross-complementing rodent repair deficiency, complementation group 3	14511	0.2
chr11_120817696_120817936	0.21	Fasn	fatty acid synthase	2361	0.15
chrY_90792035_90792186	0.21	Gm47283	predicted gene, 47283	1659	0.36
chr6_28755592_28755775	0.21	Snd1	staphylococcal nuclease and tudor domain containing 1	9007	0.22
chrX_170017443_170017594	0.21	Erdr1	erythroid differentiation regulator 1	6774	0.18
chr11_115898937_115899098	0.21	Smim5	small integral membrane protein 5	949	0.35
chr3_52985515_52985857	0.21	Cog6	component of oligomeric golgi complex 6	8999	0.16
chr9_106238560_106238771	0.20	Alas1	aminolevulinic acid synthase 1	65	0.95
chr11_64842929_64843090	0.20	Gm12292	predicted gene 12292	744	0.76
chr3_51230122_51230437	0.20	Gm38357	predicted gene, 38357	1638	0.29
chrX_12792421_12792582	0.19	Gm14634	predicted gene 14634	29957	0.15
chr16_30968839_30969241	0.19	Gm15742	predicted gene 15742	4478	0.21
chr2_44106392_44106564	0.19	Arhgap15os	Rho GTPase activating protein 15, opposite strand	41154	0.18
chr9_44087034_44087185	0.19	Usp2	ubiquitin specific peptidase 2	81	0.91
chr10_5424273_5424447	0.19	Syne1	spectrin repeat containing, nuclear envelope 1	55874	0.14
chr9_122027805_122027998	0.19	Gm47117	predicted gene, 47117	15761	0.1
chr1_151243904_151244075	0.19	Gm24402	predicted gene, 24402	16925	0.12
chr1_162891657_162891835	0.19	Fmo2	flavin containing monooxygenase 2	5231	0.19
chr1_133370822_133370973	0.19	Etnk2	ethanolamine kinase 2	3610	0.17
chr7_52391946_52392105	0.18	Gm20074	predicted gene, 20074	19428	0.28
chr10_4599676_4599928	0.18	Esr1	estrogen receptor 1 (alpha)	11791	0.21
chr9_61911741_61911892	0.18	Rplp1	ribosomal protein, large, P1	2726	0.27
chr5_115515109_115515270	0.18	Gm13840	predicted gene 13840	74	0.92
chr3_117078252_117078413	0.18	1700061I17Rik	RIKEN cDNA 1700061I17 gene	567	0.75
chr14_25312206_25312357	0.18	Gm26660	predicted gene, 26660	66354	0.1
chr6_83797123_83797297	0.18	Nagk	N-acetylglucosamine kinase	178	0.88
chr13_107469451_107469885	0.18	AI197445	expressed sequence AI197445	154	0.97
chr5_120481198_120481714	0.18	Gm15690	predicted gene 15690	553	0.54
chr17_14988060_14988226	0.17	9030025P20Rik	RIKEN cDNA 9030025P20 gene	8644	0.11
chr6_90746922_90747105	0.17	Iqsec1	IQ motif and Sec7 domain 1	10326	0.17
chr1_21166525_21166783	0.17	Gm2693	predicted gene 2693	12334	0.16
chr16_90283788_90283943	0.17	Scaf4	SR-related CTD-associated factor 4	443	0.8
chr11_16900676_16901084	0.17	Egfr	epidermal growth factor receptor	4305	0.23
chr8_25636930_25637092	0.17	Nsd3	nuclear receptor binding SET domain protein 3	3273	0.13
chr17_87302277_87302563	0.17	Ttc7	tetratricopeptide repeat domain 7	6912	0.15
chr12_31499269_31499433	0.17	Cbll1	Casitas B-lineage lymphoma-like 1	204	0.88
chr5_121564754_121565431	0.17	Aldh2	aldehyde dehydrogenase 2, mitochondrial	6095	0.1
chr11_120568518_120568669	0.16	P4hb	prolyl 4-hydroxylase, beta polypeptide	4248	0.07
chr13_44735230_44735426	0.16	Jarid2	jumonji, AT rich interactive domain 2	1288	0.56
chr17_5849675_5849852	0.16	Snx9	sorting nexin 9	8411	0.15
chr9_61348025_61348190	0.16	Gm10655	predicted gene 10655	23520	0.16
chr8_84842789_84843130	0.16	Calr	calreticulin	1957	0.13
chr17_47976252_47976712	0.16	Gm14871	predicted gene 14871	27090	0.11
chr13_8865143_8865294	0.16	Wdr37	WD repeat domain 37	3993	0.12
chr11_6026043_6026414	0.16	Camk2b	calcium/calmodulin-dependent protein kinase II, beta	25780	0.15
chr8_121973410_121973561	0.16	Gm17709	predicted gene, 17709	337	0.72
chr11_67142292_67142463	0.16	2310065F04Rik	RIKEN cDNA 2310065F04 gene	22297	0.12
chr8_109969231_109969458	0.16	Gm45795	predicted gene 45795	5008	0.14
chr15_58927649_58927810	0.16	Tatdn1	TatD DNase domain containing 1	5639	0.14
chr1_52631028_52631204	0.16	Nemp2	nuclear envelope integral membrane protein 2	319	0.86
chr17_48598725_48598879	0.16	Gm24071	predicted gene, 24071	19021	0.19
chr4_143021381_143021546	0.16	6330411D24Rik	RIKEN cDNA 6330411D24 gene	52303	0.14
chr6_15828886_15829037	0.16	Gm43990	predicted gene, 43990	7128	0.25
chr3_18251077_18251277	0.16	Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	7839	0.24
chr5_36390576_36390854	0.16	Sorcs2	sortilin-related VPS10 domain containing receptor 2	7392	0.21
chr4_36014169_36014515	0.16	Gm12369	predicted gene 12369	10163	0.27
chr11_5524215_5524690	0.16	Xbp1	X-box binding protein 1	2529	0.2
chr9_121555731_121555882	0.15	Gm47095	predicted gene, 47095	19655	0.13
chr10_87880307_87880601	0.15	Igf1os	insulin-like growth factor 1, opposite strand	17073	0.18
chr5_123907365_123907778	0.15	Denr	density-regulated protein	82	0.95
chr1_186250377_186250604	0.15	Gm37272	predicted gene, 37272	68233	0.1
chr17_28010581_28010732	0.15	Anks1	ankyrin repeat and SAM domain containing 1	3311	0.15
chr7_126932811_126932965	0.15	Kctd13	potassium channel tetramerisation domain containing 13	2967	0.08
chr5_77309423_77309744	0.15	Noa1	nitric oxide associated 1	476	0.48
chr15_59016273_59016565	0.15	Mtss1	MTSS I-BAR domain containing 1	24177	0.16
chr11_120820263_120820477	0.15	Fasn	fatty acid synthase	3410	0.12
chr3_41614429_41614618	0.15	Jade1	jade family PHD finger 1	12093	0.16
chr15_27585587_27585755	0.15	Mir7117	microRNA 7117	14177	0.15
chr18_12671580_12671783	0.15	Ttc39c	tetratricopeptide repeat domain 39C	18047	0.13
chr19_38015663_38015814	0.15	Myof	myoferlin	27613	0.14
chr11_97363051_97363241	0.15	Socs7	suppressor of cytokine signaling 7	595	0.66
chr15_100228265_100228661	0.15	Atf1	activating transcription factor 1	200	0.92
chr17_46139458_46139771	0.14	Rsph9	radial spoke head 9 homolog (Chlamydomonas)	2784	0.15
chr9_44478965_44479362	0.14	C030014I23Rik	RIKEN cDNA C030014I23 gene	385	0.49
chr10_81408031_81408226	0.14	Nfic	nuclear factor I/C	487	0.49
chr6_142788740_142788928	0.14	Sult6b2	sulfotransferase family 6B, member 2	15632	0.16
chr8_93108415_93108795	0.14	Ces1c	carboxylesterase 1C	15924	0.14
chr2_134534653_134534804	0.14	Hao1	hydroxyacid oxidase 1, liver	19579	0.27
chr7_122066462_122066699	0.14	Ears2	glutamyl-tRNA synthetase 2, mitochondrial	431	0.53
chr2_34777307_34777554	0.14	Hspa5	heat shock protein 5	2583	0.19
chr18_76305906_76306080	0.14	Gm50360	predicted gene, 50360	15831	0.21
chr3_97635501_97635936	0.14	Fmo5	flavin containing monooxygenase 5	6835	0.14
chr4_117126763_117126969	0.14	Tctex1d4	Tctex1 domain containing 4	53	0.9
chr14_65759139_65759314	0.14	Pbk	PDZ binding kinase	46611	0.13
chr2_58786750_58786901	0.14	Upp2	uridine phosphorylase 2	21500	0.19
chr5_4918481_4918656	0.14	Cdk14	cyclin-dependent kinase 14	29656	0.14
chr6_29815607_29815784	0.14	Ahcyl2	S-adenosylhomocysteine hydrolase-like 2	13836	0.18
chr5_123022889_123023101	0.14	Orai1	ORAI calcium release-activated calcium modulator 1	7657	0.09
chr6_134517015_134517190	0.14	Lrp6	low density lipoprotein receptor-related protein 6	24612	0.17
chr1_162892140_162892544	0.14	Fmo2	flavin containing monooxygenase 2	5827	0.19
chr3_94697991_94698327	0.14	Selenbp2	selenium binding protein 2	4500	0.13
chr2_20666086_20666239	0.14	Gm13362	predicted gene 13362	47072	0.16
chr3_21371390_21371542	0.14	Gm29137	predicted gene 29137	102376	0.08
chr13_109536856_109537007	0.14	Pde4d	phosphodiesterase 4D, cAMP specific	44474	0.21
chr11_28698214_28698534	0.14	2810471M01Rik	RIKEN cDNA 2810471M01 gene	16810	0.16
chr11_60256374_60256525	0.14	Tom1l2	target of myb1-like 2 (chicken)	10780	0.12
chr11_87456055_87456225	0.14	Rnu3b4	U3B small nuclear RNA 4	6146	0.09
chr15_76208375_76208737	0.14	Plec	plectin	97	0.92
chr3_94937900_94938079	0.14	Selenbp1	selenium binding protein 1	4830	0.1
chr13_37831757_37832025	0.14	Rreb1	ras responsive element binding protein 1	4498	0.22
chr13_84221796_84222007	0.13	A230107N01Rik	RIKEN cDNA A230107N01 gene	199	0.71
chr13_63520249_63520412	0.13	Ptch1	patched 1	8301	0.15
chr12_104087488_104087669	0.13	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	6929	0.1
chr3_89140809_89141081	0.13	Pklr	pyruvate kinase liver and red blood cell	4322	0.08
chr12_28629267_28629434	0.13	Rps7	ribosomal protein S7	2567	0.2
chr7_80030553_80030704	0.13	Zfp710	zinc finger protein 710	2814	0.17
chr7_34226952_34227127	0.13	Gpi1	glucose-6-phosphate isomerase 1	1958	0.17
chr4_63251381_63251799	0.13	Mir455	microRNA 455	5261	0.19
chr9_92350909_92351360	0.13	1700057G04Rik	RIKEN cDNA 1700057G04 gene	49	0.97
chr11_104441511_104441826	0.13	Kansl1	KAT8 regulatory NSL complex subunit 1	34	0.97
chr2_181044162_181044343	0.13	Chrna4	cholinergic receptor, nicotinic, alpha polypeptide 4	706	0.59
chr17_71215570_71215721	0.13	Lpin2	lipin 2	10969	0.16
chr1_58382672_58382837	0.13	Gm37607	predicted gene, 37607	3380	0.17
chr9_45095657_45095825	0.13	Jaml	junction adhesion molecule like	7053	0.09
chr10_21678793_21678948	0.13	Gm5420	predicted gene 5420	7541	0.23
chr6_72360494_72360859	0.13	Rnf181	ring finger protein 181	391	0.72
chr13_48972078_48972229	0.13	Fam120a	family with sequence similarity 120, member A	4136	0.28
chr19_10046514_10046840	0.13	Fads3	fatty acid desaturase 3	4945	0.14
chr2_160249478_160249680	0.12	Gm826	predicted gene 826	64037	0.13
chr8_84723357_84723534	0.12	G430095P16Rik	RIKEN cDNA G430095P16 gene	438	0.7
chr9_45205284_45205435	0.12	Tmprss4	transmembrane protease, serine 4	1267	0.29
chr13_55211103_55211935	0.12	Nsd1	nuclear receptor-binding SET-domain protein 1	22	0.97
chr13_44291297_44291488	0.12	Gm29676	predicted gene, 29676	10943	0.21
chr3_116162254_116162405	0.12	Gm26544	predicted gene, 26544	11850	0.13
chr4_3937763_3937914	0.12	Plag1	pleiomorphic adenoma gene 1	544	0.59
chr2_70798855_70799007	0.12	Tlk1	tousled-like kinase 1	26297	0.18
chr16_95605411_95605586	0.12	Erg	ETS transcription factor	18905	0.24
chr6_13677230_13677408	0.12	Bmt2	base methyltransferase of 25S rRNA 2	619	0.8
chr18_60217937_60218088	0.12	Gm5970	predicted gene 5970	2831	0.21
chr5_118649962_118650113	0.12	Gm43274	predicted gene 43274	5664	0.18
chr13_93710471_93710659	0.12	Dmgdh	dimethylglycine dehydrogenase precursor	974	0.45
chr10_39209250_39209435	0.12	Gm6477	predicted gene 6477	10804	0.16
chr17_15019435_15019586	0.12	Gm3435	predicted gene 3435	9175	0.12
chr15_85720937_85721131	0.12	Mirlet7b	microRNA let7b	13715	0.13
chr6_71458715_71458866	0.12	Gm44172	predicted gene, 44172	6798	0.11
chr19_30092253_30092507	0.12	Uhrf2	ubiquitin-like, containing PHD and RING finger domains 2	419	0.86
chr7_139703566_139703726	0.12	Rpl21-ps13	ribosomal protein L21-ps13	15753	0.15
chr8_126876394_126876573	0.12	Gm31718	predicted gene, 31718	45	0.98
chr11_60251360_60251526	0.12	Tom1l2	target of myb1-like 2 (chicken)	5774	0.13
chr11_102404567_102404909	0.12	Slc25a39	solute carrier family 25, member 39	245	0.47
chrX_60013443_60013609	0.12	F9	coagulation factor IX	14062	0.2
chr19_21599131_21599282	0.12	1110059E24Rik	RIKEN cDNA 1110059E24 gene	5113	0.24
chr17_33932704_33933052	0.12	Rgl2	ral guanine nucleotide dissociation stimulator-like 2	747	0.27
chr17_29431315_29431488	0.12	Gm36199	predicted gene, 36199	1434	0.29
chr13_55212302_55212785	0.12	Nsd1	nuclear receptor-binding SET-domain protein 1	157	0.94
chr3_94399233_94399394	0.12	Lingo4	leucine rich repeat and Ig domain containing 4	796	0.33
chr13_97138128_97138479	0.12	Gfm2	G elongation factor, mitochondrial 2	263	0.59
chr8_105084813_105085337	0.12	Ces3b	carboxylesterase 3B	1312	0.28
chr9_121799708_121799875	0.12	Hhatl	hedgehog acyltransferase-like	7284	0.09
chr1_134764237_134764440	0.11	Ppp1r12b	protein phosphatase 1, regulatory subunit 12B	3985	0.18
chr19_30229320_30229513	0.11	Mbl2	mannose-binding lectin (protein C) 2	3526	0.25
chr5_24502879_24503079	0.11	Agap3	ArfGAP with GTPase domain, ankyrin repeat and PH domain 3	22807	0.08
chr6_29523600_29523797	0.11	Irf5	interferon regulatory factor 5	2927	0.15
chr17_28436263_28436419	0.11	Fkbp5	FK506 binding protein 5	4669	0.12
chr1_82158565_82158766	0.11	Mir6344	microRNA 6344	26749	0.19
chr9_48604518_48604682	0.11	Nnmt	nicotinamide N-methyltransferase	477	0.86
chr12_80231463_80231884	0.11	Gm47767	predicted gene, 47767	22430	0.13
chr8_36265736_36265923	0.11	Lonrf1	LON peptidase N-terminal domain and ring finger 1	16313	0.2

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mafa

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.1	0.2	GO:0042167	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1	0.3	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.2	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.2	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0	0.1	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.2	GO:0000414	regulation of histone H3-K36 methylation(GO:0000414)
0.0	0.1	GO:0097195	pilomotor reflex(GO:0097195)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.0	0.2	GO:0032790	ribosome disassembly(GO:0032790)
0.0	0.1	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0	0.1	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.1	GO:0051581	negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.0	0.1	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.1	GO:1904016	response to Thyroglobulin triiodothyronine(GO:1904016) cellular response to Thyroglobulin triiodothyronine(GO:1904017)
0.0	0.1	GO:0000101	sulfur amino acid transport(GO:0000101)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.1	GO:0036166	phenotypic switching(GO:0036166)
0.0	0.1	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.0	0.1	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.1	GO:0061084	negative regulation of protein refolding(GO:0061084)
0.0	0.1	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.1	GO:1904430	negative regulation of t-circle formation(GO:1904430)
0.0	0.1	GO:0036112	medium-chain fatty-acyl-CoA metabolic process(GO:0036112)
0.0	0.0	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.1	GO:0070094	positive regulation of glucagon secretion(GO:0070094)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.1	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.0	GO:0048290	isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296)
0.0	0.1	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:1903798	regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798)
0.0	0.1	GO:0030259	lipid glycosylation(GO:0030259)
0.0	0.1	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.2	GO:0061032	visceral serous pericardium development(GO:0061032)
0.0	0.1	GO:0048619	embryonic hindgut morphogenesis(GO:0048619)
0.0	0.1	GO:0051031	tRNA transport(GO:0051031)
0.0	0.1	GO:0060059	embryonic retina morphogenesis in camera-type eye(GO:0060059)
0.0	0.1	GO:2001260	regulation of semaphorin-plexin signaling pathway(GO:2001260)
0.0	0.0	GO:0006296	nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.0	0.0	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.0	GO:0033122	negative regulation of purine nucleotide catabolic process(GO:0033122)
0.0	0.1	GO:0006407	rRNA export from nucleus(GO:0006407)
0.0	0.0	GO:0006172	ADP biosynthetic process(GO:0006172)
0.0	0.0	GO:0001560	regulation of cell growth by extracellular stimulus(GO:0001560)
0.0	0.1	GO:0070417	cellular response to cold(GO:0070417)
0.0	0.1	GO:0060158	phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.0	0.0	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0017121	phospholipid scrambling(GO:0017121)
0.0	0.1	GO:0051574	positive regulation of histone H3-K9 methylation(GO:0051574)
0.0	0.1	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.0	0.0	GO:1904380	endoplasmic reticulum mannose trimming(GO:1904380)
0.0	0.0	GO:0002572	pro-T cell differentiation(GO:0002572)
0.0	0.0	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.3	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.1	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.0	0.0	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.0	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.0	0.0	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.1	GO:0070127	tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0	0.0	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.0	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.1	GO:0006561	proline biosynthetic process(GO:0006561)
0.0	0.0	GO:0045218	zonula adherens maintenance(GO:0045218)
0.0	0.0	GO:0035522	monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.0	0.0	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.0	GO:0021943	formation of radial glial scaffolds(GO:0021943)
0.0	0.0	GO:0060988	lipid tube assembly(GO:0060988)
0.0	0.0	GO:0030167	proteoglycan catabolic process(GO:0030167)
0.0	0.0	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.0	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
0.0	0.0	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.0	GO:2001184	positive regulation of interleukin-12 secretion(GO:2001184)
0.0	0.0	GO:0000087	mitotic M phase(GO:0000087)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:0035356	cellular triglyceride homeostasis(GO:0035356)
0.0	0.0	GO:0061043	regulation of vascular wound healing(GO:0061043)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.2	GO:0045475	locomotor rhythm(GO:0045475)
0.0	0.0	GO:0046951	ketone body biosynthetic process(GO:0046951)
0.0	0.0	GO:0046469	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0097427	microtubule bundle(GO:0097427)
0.2	GO:0031094	platelet dense tubular network(GO:0031094)
0.1	GO:0097433	dense body(GO:0097433)
0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.1	GO:0070876	SOSS complex(GO:0070876)
0.1	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.1	GO:0030056	hemidesmosome(GO:0030056)
0.0	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.1	GO:0070847	core mediator complex(GO:0070847)
0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.1	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0005315	inorganic phosphate transmembrane transporter activity(GO:0005315)
0.1	0.3	GO:0019145	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0015222	serotonin transmembrane transporter activity(GO:0015222)
0.0	0.2	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.1	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.3	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0032564	dATP binding(GO:0032564)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.1	GO:0008240	tripeptidyl-peptidase activity(GO:0008240)
0.0	0.1	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.1	GO:0034056	estrogen response element binding(GO:0034056)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0046976	histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.1	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.0	0.0	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0098505	G-rich strand telomeric DNA binding(GO:0098505)
0.0	0.1	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.2	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0	0.1	GO:0019960	C-X3-C chemokine binding(GO:0019960)
0.0	0.0	GO:0016802	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.0	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.1	GO:0000099	sulfur amino acid transmembrane transporter activity(GO:0000099)
0.0	0.1	GO:1990932	5.8S rRNA binding(GO:1990932)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.0	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.0	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.1	GO:0043996	histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
0.0	0.1	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.0	0.1	GO:0004534	5'-3' exoribonuclease activity(GO:0004534)
0.0	0.1	GO:0050321	tau-protein kinase activity(GO:0050321)
0.0	0.0	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.2	GO:0017128	phospholipid scramblase activity(GO:0017128)
0.0	0.1	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.0	GO:0005275	amine transmembrane transporter activity(GO:0005275)
0.0	0.0	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.3	GO:0043014	alpha-tubulin binding(GO:0043014)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels
0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.2	REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS	Genes involved in Na+/Cl- dependent neurotransmitter transporters