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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Mbd2

Z-value: 0.89

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Transcription factors associated with Mbd2

Gene Symbol Gene ID Gene Info
Mbd2
ENSMUSG00000024513.10 Mbd2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

GenePromoterDistanceAssociation probabilityPearson corr. coef.P-valuePlot
Mbd2chr18_70567012_7056716311020.5098810.901.5e-02Click!
Mbd2chr18_70573928_7057415357060.2083470.843.7e-02Click!
Mbd2chr18_70620204_7062039325250.2950510.805.4e-02Click!
Mbd2chr18_70567312_705674867900.6413160.805.6e-02Click!
Mbd2chr18_70574437_7057459561820.2054130.786.9e-02Click!

Activity of the Mbd2 motif across conditions

Conditions sorted by the z-value of the Mbd2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr11_98588166_98588531 0.37 Ormdl3
 ORM1-like 3 (S. cerevisiae)
 980
 0.38
chr2_130450428_130450784 0.32 Ptpra
 protein tyrosine phosphatase, receptor type, A
 62
 0.95
chr16_17131597_17132007 0.32 Sdf2l1
 stromal cell-derived factor 2-like 1
 581
 0.49
chr8_122550942_122551215 0.31 Piezo1
 piezo-type mechanosensitive ion channel component 1
 251
 0.84
chr16_17928117_17928461 0.29 Slc25a1
 solute carrier family 25 (mitochondrial carrier, citrate transporter), member 1
 70
 0.94
chr16_45843772_45843939 0.28 Phldb2
 pleckstrin homology like domain, family B, member 2
 379
 0.88
chr9_44083899_44084207 0.28 Usp2
 ubiquitin specific peptidase 2
 886
 0.32
chr10_61715458_61715732 0.27 Aifm2
 apoptosis-inducing factor, mitochondrion-associated 2
 263
 0.88
chr17_28518297_28518448 0.27 Fkbp5
 FK506 binding protein 5
 845
 0.32
chr8_95633615_95633766 0.26 Gins3
 GINS complex subunit 3 (Psf3 homolog)
 136
 0.93
chr18_3507262_3507648 0.26 Bambi
 BMP and activin membrane-bound inhibitor
 468
 0.77
chr17_28485541_28485711 0.24 Fkbp5
 FK506 binding protein 5
 467
 0.65
chr11_107548058_107548221 0.24 Helz
 helicase with zinc finger domain
 171
 0.57
chr12_102704764_102704984 0.24 Itpk1
 inositol 1,3,4-triphosphate 5/6 kinase
 40
 0.95
chr6_113604837_113605061 0.23 Brk1
 BRICK1, SCAR/WAVE actin-nucleating complex subunit
 177
 0.85
chr9_95559372_95559553 0.22 Paqr9
 progestin and adipoQ receptor family member IX
 195
 0.91
chr8_70905885_70906054 0.22 Map1s
 microtubule-associated protein 1S
 13
 0.94
chr7_139188415_139188566 0.21 Stk32c
 serine/threonine kinase 32C
 27
 0.97
chr7_39487472_39487798 0.21 Gm28455
 predicted gene 28455
 1803
 0.25
chr15_102090068_102090474 0.21 Eif4b
 eukaryotic translation initiation factor 4B
 4247
 0.14
chr16_32867691_32868221 0.21 Rubcn
 RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein
 382
 0.81
chr14_18238484_18238667 0.21 Nr1d2
 nuclear receptor subfamily 1, group D, member 2
 436
 0.77
chr1_89940488_89940663 0.21 Gbx2
 gastrulation brain homeobox 2
 9396
 0.19
chr16_20301821_20302010 0.20 Parl
 presenilin associated, rhomboid-like
 102
 0.96
chr1_88702033_88702468 0.20 Arl4c
 ADP-ribosylation factor-like 4C
 29
 0.97
chr11_78343717_78343868 0.20 Unc119
 unc-119 lipid binding chaperone
 247
 0.83
chrX_52988531_52988855 0.20 Hprt
 hypoxanthine guanine phosphoribosyl transferase
 556
 0.67
chr13_54504145_54504307 0.20 Simc1
 SUMO-interacting motifs containing 1
 417
 0.77
chr2_153444307_153444698 0.19 Nol4l
 nucleolar protein 4-like
 23
 0.98
chr8_81014588_81014762 0.19 Usp38
 ubiquitin specific peptidase 38
 238
 0.71
chr5_122284523_122284674 0.19 Pptc7
 PTC7 protein phosphatase homolog
 233
 0.88
chr17_87107670_87107838 0.19 Socs5
 suppressor of cytokine signaling 5
 63
 0.97
chr4_119539797_119539948 0.19 Foxj3
 forkhead box J3
 93
 0.77
chr1_128103472_128103650 0.19 R3hdm1
 R3H domain containing 1
 230
 0.7
chr15_59633802_59633963 0.19 Trib1
 tribbles pseudokinase 1
 14468
 0.19
chr8_35725273_35725452 0.19 Gm35021
 predicted gene, 35021
 82
 0.96
chr16_33381353_33381732 0.19 Zfp148
 zinc finger protein 148
 76
 0.94
chr10_115385093_115385251 0.19 Zfc3h1
 zinc finger, C3H1-type containing
 213
 0.82
chr13_56134831_56134982 0.19 Macroh2a1
 macroH2A.1 histone
 81
 0.97
chr4_117886820_117887048 0.18 Atp6v0b
 ATPase, H+ transporting, lysosomal V0 subunit B
 298
 0.78
chr8_83699110_83699282 0.18 Pkn1
 protein kinase N1
 17
 0.96
chr2_70509001_70509542 0.18 Erich2os
 glutamate rich 2, opposite strand
 72
 0.66
chr1_152386380_152386577 0.18 Tsen15
 tRNA splicing endonuclease subunit 15
 114
 0.97
chr13_54574971_54575187 0.18 Arl10
 ADP-ribosylation factor-like 10
 32
 0.95
chr2_155473861_155474012 0.18 Ncoa6
 nuclear receptor coactivator 6
 42
 0.96
chr1_135375014_135375173 0.18 Shisa4
 shisa family member 4
 16
 0.96
chr1_156673428_156673871 0.18 Tor3a
 torsin family 3, member A
 665
 0.65
chr2_26588564_26589214 0.17 Egfl7
 EGF-like domain 7
 346
 0.71
chr1_180569064_180569225 0.17 Parp1
 poly (ADP-ribose) polymerase family, member 1
 82
 0.97
chr1_93754083_93754286 0.17 Thap4
 THAP domain containing 4
 466
 0.56
chr14_65098086_65098260 0.17 Extl3
 exostosin-like glycosyltransferase 3
 67
 0.98
chr2_26503007_26503238 0.17 Notch1
 notch 1
 700
 0.54
chr2_32846890_32847041 0.17 Stxbp1
 syntaxin binding protein 1
 237
 0.78
chr5_90589028_90589209 0.17 Gm42109
 predicted gene, 42109
 41
 0.97
chr10_57486792_57486966 0.17 Hsf2
 heat shock factor 2
 454
 0.51
chr11_119056746_119056911 0.17 Cbx8
 chromobox 8
 15859
 0.14
chr9_119143653_119143908 0.17 Acaa1b
 acetyl-Coenzyme A acyltransferase 1B
 6283
 0.12
chr12_86421804_86421960 0.17 Esrrb
 estrogen related receptor, beta
 1
 0.98
chr8_35588423_35588931 0.17 Mfhas1
 malignant fibrous histiocytoma amplified sequence 1
 279
 0.5
chr1_190149690_190149867 0.17 Gm28172
 predicted gene 28172
 18892
 0.18
chr7_27452561_27452934 0.16 Blvrb
 biliverdin reductase B (flavin reductase (NADPH))
 303
 0.79
chr11_60913758_60913958 0.16 Natd1
 N-acetyltransferase domain containing 1
 46
 0.96
chr7_34653059_34653454 0.16 Kctd15
 potassium channel tetramerisation domain containing 15
 56
 0.51
chr4_134767914_134768168 0.16 Ldlrap1
 low density lipoprotein receptor adaptor protein 1
 17
 0.98
chr4_132345674_132345841 0.16 Rcc1
 regulator of chromosome condensation 1
 10
 0.93
chr4_147442937_147443122 0.16 Gm13161
 predicted gene 13161
 442
 0.71
chr16_26643088_26643295 0.16 Il1rap
 interleukin 1 receptor accessory protein
 19035
 0.26
chr2_26389257_26389428 0.16 Pmpca
 peptidase (mitochondrial processing) alpha
 3
 0.49
chr5_90931414_90931780 0.16 Mthfd2l
 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like
 317
 0.85
chr7_16273015_16273208 0.16 Inafm1
 InaF motif containing 1
 506
 0.63
chr7_49778522_49778862 0.16 Prmt3
 protein arginine N-methyltransferase 3
 148
 0.96
chr3_87617470_87617634 0.15 Arhgef11
 Rho guanine nucleotide exchange factor (GEF) 11
 7
 0.66
chr5_88600656_88600807 0.15 Rufy3
 RUN and FYVE domain containing 3
 16937
 0.16
chr19_47580113_47580699 0.15 Slk
 STE20-like kinase
 387
 0.82
chr16_45158641_45158816 0.15 Slc35a5
 solute carrier family 35, member A5
 22
 0.52
chr11_58168082_58168288 0.15 Gemin5
 gem nuclear organelle associated protein 5
 354
 0.77
chrX_20426243_20426394 0.15 Jade3
 jade family PHD finger 3
 530
 0.73
chr1_98095204_98095355 0.15 Pam
 peptidylglycine alpha-amidating monooxygenase
 342
 0.88
chr11_88161368_88161548 0.15 Cuedc1
 CUE domain containing 1
 803
 0.62
chr9_56160728_56160881 0.15 Tspan3
 tetraspanin 3
 15
 0.98
chr8_109982243_109982440 0.15 Gm45795
 predicted gene 45795
 7989
 0.12
chr14_55721616_55722015 0.15 Rabggta
 Rab geranylgeranyl transferase, a subunit
 361
 0.66
chr18_67800248_67800418 0.15 Cep192
 centrosomal protein 192
 199
 0.68
chr3_142765428_142765623 0.15 Gtf2b
 general transcription factor IIB
 302
 0.84
chr11_75173089_75173918 0.14 Mir212
 microRNA 212
 115
 0.56
chr9_18292420_18292623 0.14 Chordc1
 cysteine and histidine-rich domain (CHORD)-containing, zinc-binding protein 1
 133
 0.95
chr17_26932920_26933100 0.14 Phf1
 PHD finger protein 1
 42
 0.92
chr15_93398257_93398420 0.14 Zcrb1
 zinc finger CCHC-type and RNA binding motif 1
 4
 0.5
chr4_148038831_148039191 0.14 Mthfr
 methylenetetrahydrofolate reductase
 66
 0.66
chr4_117289529_117289862 0.14 Rnf220
 ring finger protein 220
 135
 0.93
chr8_88362172_88362513 0.14 Brd7
 bromodomain containing 7
 148
 0.96
chrX_12761746_12762400 0.14 Med14
 mediator complex subunit 14
 0
 0.73
chr6_116193076_116193281 0.14 Tmcc1
 transmembrane and coiled coil domains 1
 308
 0.82
chr1_138856758_138856925 0.14 2310009B15Rik
 RIKEN cDNA 2310009B15 gene
 6
 0.97
chr9_64253292_64253498 0.14 Map2k1
 mitogen-activated protein kinase kinase 1
 236
 0.86
chr6_128843572_128843953 0.14 Gm44066
 predicted gene, 44066
 591
 0.53
chr10_110745240_110745533 0.14 E2f7
 E2F transcription factor 7
 53
 0.98
chr11_84828922_84829202 0.14 Dhrs11
 dehydrogenase/reductase (SDR family) member 11
 68
 0.56
chr1_136625470_136625621 0.13 Zfp281
 zinc finger protein 281
 644
 0.47
chr2_30062412_30062574 0.13 Set
 SET nuclear oncogene
 108
 0.94
chrX_10718554_10718705 0.13 Gm14493
 predicted gene 14493
 81
 0.95
chr8_109705810_109706060 0.13 Zfp821
 zinc finger protein 821
 153
 0.94
chr1_187609518_187609683 0.13 Esrrg
 estrogen-related receptor gamma
 96
 0.98
chr2_93334519_93334694 0.13 Tspan18
 tetraspanin 18
 101
 0.97
chr15_96288000_96288151 0.13 Arid2
 AT rich interactive domain 2 (ARID, RFX-like)
 502
 0.79
chr6_88198537_88198710 0.13 Gata2
 GATA binding protein 2
 289
 0.86
chr6_83135074_83135242 0.13 Rtkn
 rhotekin
 305
 0.69
chr6_90716112_90716407 0.13 Iqsec1
 IQ motif and Sec7 domain 1
 270
 0.9
chr7_49778222_49778382 0.13 Prmt3
 protein arginine N-methyltransferase 3
 44
 0.98
chr7_127345321_127345481 0.13 Zfp768
 zinc finger protein 768
 22
 0.94
chr14_46832312_46832505 0.13 Cgrrf1
 cell growth regulator with ring finger domain 1
 164
 0.71
chr12_112950230_112950445 0.13 Gm26583
 predicted gene, 26583
 175
 0.89
chr8_83998442_83998628 0.13 Samd1
 sterile alpha motif domain containing 1
 111
 0.9
chr14_34317951_34318429 0.12 Glud1
 glutamate dehydrogenase 1
 7463
 0.1
chr19_38055072_38055331 0.12 Cep55
 centrosomal protein 55
 112
 0.89
chr18_60750592_60750964 0.12 Ndst1
 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
 2128
 0.23
chr7_63919537_63919733 0.12 E030018B13Rik
 RIKEN cDNA E030018B13 gene
 2778
 0.19
chr18_25168691_25169056 0.12 AW554918
 expressed sequence AW554918
 126
 0.51
chr4_129461813_129461998 0.12 Bsdc1
 BSD domain containing 1
 69
 0.94
chrX_60547467_60547618 0.12 Gm715
 predicted gene 715
 477
 0.75
chr15_39944302_39944559 0.12 Lrp12
 low density lipoprotein-related protein 12
 436
 0.82
chr7_46919659_46919883 0.12 Tsg101
 tumor susceptibility gene 101
 98
 0.93
chr17_65772581_65772765 0.12 Rab31
 RAB31, member RAS oncogene family
 33
 0.98
chr7_30957117_30957268 0.12 Gm4673
 predicted gene 4673
 217
 0.61
chr3_89907720_89908002 0.12 Gm42809
 predicted gene 42809
 5055
 0.12
chr10_79706208_79706359 0.12 Bsg
 basigin
 1713
 0.15
chr17_12389802_12390011 0.12 Plg
 plasminogen
 11247
 0.16
chr10_121739546_121739745 0.12 BC048403
 cDNA sequence BC048403
 292
 0.91
chr6_51325666_51325826 0.12 Gm32479
 predicted gene, 32479
 37891
 0.14
chr4_134287574_134287752 0.12 Pdik1l
 PDLIM1 interacting kinase 1 like
 232
 0.86
chr14_45657978_45658304 0.12 Ddhd1
 DDHD domain containing 1
 1
 0.56
chr5_135888324_135888475 0.12 Hspb1
 heat shock protein 1
 381
 0.75
chr4_89311006_89311177 0.12 Cdkn2b
 cyclin dependent kinase inhibitor 2B
 52
 0.97
chr7_89337730_89338159 0.12 Gm44995
 predicted gene 44995
 426
 0.63
chr15_76069223_76069568 0.12 Scrib
 scribbled planar cell polarity
 359
 0.68
chrX_9272438_9272819 0.11 Xk
 X-linked Kx blood group
 128
 0.94
chr1_133024897_133025230 0.11 Mdm4
 transformed mouse 3T3 cell double minute 4
 267
 0.78
chr11_103360146_103360491 0.11 Arhgap27
 Rho GTPase activating protein 27
 582
 0.61
chr7_89403924_89404083 0.11 Tmem135
 transmembrane protein 135
 219
 0.64
chr4_123411698_123411892 0.11 Macf1
 microtubule-actin crosslinking factor 1
 433
 0.82
chr8_84832176_84832355 0.11 Dand5
 DAN domain family member 5, BMP antagonist
 144
 0.83
chr9_47582784_47583204 0.11 Cadm1
 cell adhesion molecule 1
 52621
 0.13
chr11_101070221_101070380 0.11 Naglu
 alpha-N-acetylglucosaminidase (Sanfilippo disease IIIB)
 288
 0.79
chr7_44645890_44646064 0.11 Gm18256
 predicted gene, 18256
 549
 0.58
chr5_102069359_102069519 0.11 Wdfy3
 WD repeat and FYVE domain containing 3
 482
 0.61
chr9_69989339_69989508 0.11 Bnip2
 BCL2/adenovirus E1B interacting protein 2
 43
 0.9
chr4_63216102_63216460 0.11 Col27a1
 collagen, type XXVII, alpha 1
 846
 0.59
chr5_93206054_93206360 0.11 Ccni
 cyclin I
 221
 0.59
chr19_7196055_7196232 0.11 Otub1
 OTU domain, ubiquitin aldehyde binding 1
 4321
 0.15
chr5_74068640_74068846 0.11 Usp46
 ubiquitin specific peptidase 46
 312
 0.82
chr10_9901181_9901520 0.11 Gm46210
 predicted gene, 46210
 37
 0.79
chr8_120668006_120668174 0.11 Emc8
 ER membrane protein complex subunit 8
 3
 0.38
chr6_83109169_83109423 0.11 Mrpl53
 mitochondrial ribosomal protein L53
 176
 0.53
chr6_125131489_125131640 0.11 Nop2
 NOP2 nucleolar protein
 345
 0.7
chr7_97081394_97081770 0.11 Gab2
 growth factor receptor bound protein 2-associated protein 2
 4
 0.98
chr5_104218998_104219158 0.11 Dmp1
 dentin matrix protein 1
 16465
 0.15
chr18_74064019_74064179 0.11 Mapk4
 mitogen-activated protein kinase 4
 293
 0.83
chr17_88441455_88441615 0.11 Foxn2
 forkhead box N2
 760
 0.66
chr8_85555040_85555462 0.11 Dnaja2
 DnaJ heat shock protein family (Hsp40) member A2
 93
 0.97
chr4_135656378_135656550 0.11 1700029M20Rik
 RIKEN cDNA 1700029M20 gene
 29211
 0.11
chr3_152396303_152396479 0.11 Zzz3
 zinc finger, ZZ domain containing 3
 259
 0.84
chr6_140626846_140626997 0.11 Aebp2
 AE binding protein 2
 39
 0.98
chr5_136961771_136961940 0.11 Fis1
 fission, mitochondrial 1
 222
 0.86
chr5_25499515_25499834 0.10 Kmt2c
 lysine (K)-specific methyltransferase 2C
 891
 0.47
chr15_76710766_76710918 0.10 Lrrc14
 leucine rich repeat containing 14
 111
 0.7
chr12_31949810_31949961 0.10 Hbp1
 high mobility group box transcription factor 1
 277
 0.92
chr4_99120849_99121001 0.10 Dock7
 dedicator of cytokinesis 7
 10
 0.97
chr5_143527474_143527638 0.10 Rac1
 Rac family small GTPase 1
 437
 0.73
chr17_71552178_71552344 0.10 Spdya
 speedy/RINGO cell cycle regulator family, member A
 189
 0.9
chr4_155492144_155492592 0.10 Gnb1
 guanine nucleotide binding protein (G protein), beta 1
 541
 0.64
chr6_101377934_101378107 0.10 Pdzrn3
 PDZ domain containing RING finger 3
 123
 0.96
chr19_37695856_37696027 0.10 Cyp26a1
 cytochrome P450, family 26, subfamily a, polypeptide 1
 1857
 0.32
chr8_34965417_34965568 0.10 Tnks
 tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase
 198
 0.72
chr11_94321873_94322587 0.10 Luc7l3
 LUC7-like 3 (S. cerevisiae)
 242
 0.9
chr3_69126767_69126936 0.10 Kpna4
 karyopherin (importin) alpha 4
 221
 0.9
chr17_24470568_24470947 0.10 Pgp
 phosphoglycolate phosphatase
 322
 0.51
chr12_108269801_108270015 0.10 Ccdc85c
 coiled-coil domain containing 85C
 5225
 0.2
chr8_108745611_108745766 0.10 Gm38042
 predicted gene, 38042
 8095
 0.24
chr12_16894847_16894998 0.10 Rock2
 Rho-associated coiled-coil containing protein kinase 2
 27
 0.97
chr1_82815899_82816254 0.10 Gm28942
 predicted gene 28942
 3759
 0.11
chr13_31559937_31560122 0.10 A530084C06Rik
 RIKEN cDNA A530084C06 gene
 696
 0.58
chr11_105181263_105181626 0.10 1700052K11Rik
 RIKEN cDNA 1700052K11 gene
 11
 0.56
chr2_167349082_167349264 0.10 B4galt5
 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
 10
 0.98
chr1_132008229_132008400 0.10 Elk4
 ELK4, member of ETS oncogene family
 17
 0.97
chr8_24554600_24554765 0.10 Ido2
 indoleamine 2,3-dioxygenase 2
 85
 0.97
chr4_58912380_58912600 0.10 Ecpas
 Ecm29 proteasome adaptor and scaffold
 214
 0.93
chr15_41789183_41789334 0.10 Oxr1
 oxidation resistance 1
 123
 0.77
chr1_166309098_166309279 0.10 5330438I03Rik
 RIKEN cDNA 5330438I03 gene
 397
 0.85
chr16_44724144_44724299 0.10 Nepro
 nucleolus and neural progenitor protein
 80
 0.97
chr2_105016740_105016924 0.10 Eif3m
 eukaryotic translation initiation factor 3, subunit M
 211
 0.59
chr8_84200664_84200922 0.10 Gm37352
 predicted gene, 37352
 76
 0.9
chr10_71344349_71344511 0.09 Cisd1
 CDGSH iron sulfur domain 1
 524
 0.7
chr17_44736318_44736469 0.09 Runx2
 runt related transcription factor 2
 217
 0.78
chr15_84923081_84923412 0.09 Nup50
 nucleoporin 50
 165
 0.92
chr15_98871705_98871879 0.09 Kmt2d
 lysine (K)-specific methyltransferase 2D
 588
 0.34
chr4_133633066_133633255 0.09 Zdhhc18
 zinc finger, DHHC domain containing 18
 309
 0.83
chr8_47674837_47675003 0.09 Ing2
 inhibitor of growth family, member 2
 238
 0.69
chr19_7240751_7240928 0.09 Naa40
 N(alpha)-acetyltransferase 40, NatD catalytic subunit
 195
 0.89
chr5_130029440_130029773 0.09 Crcp
 calcitonin gene-related peptide-receptor component protein
 263
 0.57
chr15_12117744_12117919 0.09 Zfr
 zinc finger RNA binding protein
 0
 0.97

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

StringDB image

First level regulatory network of Mbd2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070212 protein poly-ADP-ribosylation(GO:0070212)
0.1 0.3 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.1 0.3 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.1 0.2 GO:0043553 negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.1 0.2 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1 0.1 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
0.1 0.2 GO:1900186 negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.1 0.2 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.1 0.2 GO:1900060 negative regulation of ceramide biosynthetic process(GO:1900060)
0.0 0.1 GO:0046098 guanine metabolic process(GO:0046098)
0.0 0.1 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
0.0 0.1 GO:0071930 negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0 0.1 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.0 0.1 GO:0042167 heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0 0.2 GO:0035405 histone-threonine phosphorylation(GO:0035405)
0.0 0.1 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0 0.2 GO:0000032 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589)
0.0 0.2 GO:0010825 positive regulation of centrosome duplication(GO:0010825)
0.0 0.2 GO:0071638 negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
0.0 0.1 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0 0.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.1 GO:0007412 axon target recognition(GO:0007412)
0.0 0.1 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0 0.1 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.0 0.1 GO:0070827 chromatin maintenance(GO:0070827)
0.0 0.1 GO:0045726 positive regulation of integrin biosynthetic process(GO:0045726)
0.0 0.1 GO:0010961 cellular magnesium ion homeostasis(GO:0010961)
0.0 0.1 GO:0006227 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.0 0.2 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.1 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.0 0.1 GO:0035973 aggrephagy(GO:0035973)
0.0 0.1 GO:0009249 protein lipoylation(GO:0009249)
0.0 0.1 GO:0051599 response to hydrostatic pressure(GO:0051599)
0.0 0.0 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.0 0.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.0 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.1 GO:0021747 cochlear nucleus development(GO:0021747)
0.0 0.0 GO:0048320 axial mesoderm formation(GO:0048320)
0.0 0.1 GO:0031086 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0 0.2 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.1 GO:0006547 histidine metabolic process(GO:0006547)
0.0 0.1 GO:0046208 spermine catabolic process(GO:0046208)
0.0 0.2 GO:0032957 inositol trisphosphate metabolic process(GO:0032957)
0.0 0.1 GO:0032439 endosome localization(GO:0032439)
0.0 0.1 GO:0032367 intracellular cholesterol transport(GO:0032367)
0.0 0.1 GO:0070858 negative regulation of bile acid biosynthetic process(GO:0070858) negative regulation of bile acid metabolic process(GO:1904252)
0.0 0.1 GO:0002051 osteoblast fate commitment(GO:0002051)
0.0 0.1 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.0 0.2 GO:0035413 positive regulation of catenin import into nucleus(GO:0035413)
0.0 0.2 GO:0043653 mitochondrial fragmentation involved in apoptotic process(GO:0043653)
0.0 0.1 GO:0045218 zonula adherens maintenance(GO:0045218)
0.0 0.1 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.0 0.0 GO:1901187 regulation of ephrin receptor signaling pathway(GO:1901187)
0.0 0.1 GO:1904469 positive regulation of tumor necrosis factor secretion(GO:1904469)
0.0 0.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.0 GO:2001055 positive regulation of mesenchymal cell apoptotic process(GO:2001055)
0.0 0.1 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.0 0.2 GO:0014041 regulation of neuron maturation(GO:0014041)
0.0 0.0 GO:0060672 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.0 0.0 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.0 0.1 GO:0033129 positive regulation of histone phosphorylation(GO:0033129)
0.0 0.0 GO:1903237 negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0 0.1 GO:0090188 negative regulation of pancreatic juice secretion(GO:0090188)
0.0 0.1 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
0.0 0.3 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.0 0.2 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.0 GO:0009189 deoxyribonucleoside diphosphate biosynthetic process(GO:0009189)
0.0 0.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
0.0 0.0 GO:0046881 positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0 0.1 GO:1904869 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
0.0 0.1 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0 0.0 GO:1900107 regulation of nodal signaling pathway(GO:1900107)
0.0 0.0 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0 0.0 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0 0.0 GO:0035793 positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0 0.2 GO:0090201 negative regulation of release of cytochrome c from mitochondria(GO:0090201)
0.0 0.1 GO:0043983 histone H4-K12 acetylation(GO:0043983)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 0.1 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
0.0 0.0 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
0.0 0.1 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 0.0 GO:0016103 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
0.0 0.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 0.1 GO:0010587 miRNA catabolic process(GO:0010587)
0.0 0.0 GO:2000828 regulation of parathyroid hormone secretion(GO:2000828)
0.0 0.0 GO:0002025 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025)
0.0 0.2 GO:0045475 locomotor rhythm(GO:0045475)
0.0 0.0 GO:1901492 positive regulation of lymphangiogenesis(GO:1901492)
0.0 0.1 GO:0046599 regulation of centriole replication(GO:0046599)
0.0 0.0 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015)
0.0 0.0 GO:0016259 selenocysteine metabolic process(GO:0016259)
0.0 0.1 GO:0051382 kinetochore assembly(GO:0051382)
0.0 0.0 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
0.0 0.1 GO:0038033 positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway(GO:0038033)
0.0 0.2 GO:0043306 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.0 GO:0033566 gamma-tubulin complex localization(GO:0033566)
0.0 0.0 GO:0001555 oocyte growth(GO:0001555)
0.0 0.1 GO:0007035 vacuolar acidification(GO:0007035)
0.0 0.0 GO:0072602 interleukin-4 secretion(GO:0072602)
0.0 0.0 GO:0043974 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0 0.0 GO:1900127 positive regulation of hyaluronan biosynthetic process(GO:1900127)
0.0 0.1 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
0.0 0.0 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0 0.2 GO:0035339 SPOTS complex(GO:0035339)
0.0 0.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.1 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0 0.1 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220)
0.0 0.1 GO:0097512 cardiac myofibril(GO:0097512)
0.0 0.2 GO:0045180 basal cortex(GO:0045180)
0.0 0.1 GO:0034750 Scrib-APC-beta-catenin complex(GO:0034750)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0070847 core mediator complex(GO:0070847)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.1 GO:0032444 activin responsive factor complex(GO:0032444)
0.0 0.1 GO:0036449 microtubule minus-end(GO:0036449)
0.0 0.2 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 0.1 GO:0031209 SCAR complex(GO:0031209)
0.0 0.1 GO:0005915 zonula adherens(GO:0005915)
0.0 0.1 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.0 0.1 GO:0098536 deuterosome(GO:0098536)
0.0 0.0 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.2 GO:0000242 pericentriolar material(GO:0000242)
0.0 0.1 GO:0032797 SMN complex(GO:0032797)
0.0 0.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.0 0.2 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 0.0 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.1 GO:0031616 spindle pole centrosome(GO:0031616)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.1 0.2 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
0.0 0.1 GO:0004487 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0 0.1 GO:0016649 electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0 0.2 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0 0.2 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.0 0.1 GO:0016842 amidine-lyase activity(GO:0016842)
0.0 0.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.2 GO:0035184 histone threonine kinase activity(GO:0035184)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.2 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.0 0.1 GO:0018558 2,3-dihydroxy DDT 1,2-dioxygenase activity(GO:0018542) phenanthrene dioxygenase activity(GO:0018555) 2,2',3-trihydroxybiphenyl dioxygenase activity(GO:0018556) 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity(GO:0018557) 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity(GO:0018558) 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity(GO:0018559) protocatechuate 3,4-dioxygenase type II activity(GO:0018560) 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity(GO:0018561) 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity(GO:0018562) 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity(GO:0018563) carbazole 1,9a-dioxygenase activity(GO:0018564) dihydroxydibenzothiophene dioxygenase activity(GO:0018565) 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity(GO:0018566) styrene dioxygenase activity(GO:0018567) 3,4-dihydroxyphenanthrene dioxygenase activity(GO:0018568) hydroquinone 1,2-dioxygenase activity(GO:0018569) p-cumate 2,3-dioxygenase activity(GO:0018570) 2,3-dihydroxy-p-cumate dioxygenase activity(GO:0018571) 3,5-dichlorocatechol 1,2-dioxygenase activity(GO:0018572) 2-aminophenol 1,6-dioxygenase activity(GO:0018573) 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity(GO:0018574) chlorocatechol 1,2-dioxygenase activity(GO:0018575) catechol dioxygenase activity(GO:0019114) dihydroxyfluorene dioxygenase activity(GO:0019117) 5-aminosalicylate dioxygenase activity(GO:0034543) 3-hydroxy-2-naphthoate 2,3-dioxygenase activity(GO:0034803) benzo(a)pyrene 11,12-dioxygenase activity(GO:0034806) benzo(a)pyrene 4,5-dioxygenase activity(GO:0034808) 4,5-dihydroxybenzo(a)pyrene dioxygenase activity(GO:0034810) benzo(a)pyrene 9,10-dioxygenase activity(GO:0034811) 9,10-dihydroxybenzo(a)pyrene dioxygenase activity(GO:0034812) benzo(a)pyrene 7,8-dioxygenase activity(GO:0034813) 7,8-dihydroxy benzo(a)pyrene dioxygenase activity(GO:0034814) 1,2-dihydroxy-5,6,7,8-tetrahydronaphthalene extradiol dioxygenase activity(GO:0034827) 2-mercaptobenzothiazole dioxygenase activity(GO:0034834) pyridine-3,4-diol dioxygenase activity(GO:0034895) pyrene dioxygenase activity(GO:0034920) 4,5-dihydroxypyrene dioxygenase activity(GO:0034922) phenanthrene-4-carboxylate dioxygenase activity(GO:0034934) tetrachlorobenzene dioxygenase activity(GO:0034935) 4,6-dichloro-3-methylcatechol 1,2-dioxygenase activity(GO:0034936) 2,3-dihydroxydiphenyl ether dioxygenase activity(GO:0034955) diphenyl ether 1,2-dioxygenase activity(GO:0034956) arachidonate 8(S)-lipoxygenase activity(GO:0036403) 4-hydroxycatechol 1,2-dioxygenase activity(GO:0047074)
0.0 0.1 GO:0016015 morphogen activity(GO:0016015)
0.0 0.2 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.1 GO:0009041 uridylate kinase activity(GO:0009041)
0.0 0.1 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.1 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.0 0.1 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.0 0.1 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.0 0.1 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0102007 lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0 0.1 GO:0050692 DBD domain binding(GO:0050692)
0.0 0.2 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0032184 SUMO polymer binding(GO:0032184)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.1 GO:0048763 calcium-induced calcium release activity(GO:0048763)
0.0 0.1 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 0.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.1 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.0 0.0 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
0.0 0.1 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0 0.0 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.0 0.0 GO:0035175 histone kinase activity (H3-S10 specific)(GO:0035175)
0.0 0.2 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.0 0.1 GO:0004449 isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0 0.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.0 0.0 GO:0015087 cobalt ion transmembrane transporter activity(GO:0015087)
0.0 0.1 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.1 GO:0031685 adenosine receptor binding(GO:0031685)
0.0 0.1 GO:0035368 selenocysteine insertion sequence binding(GO:0035368)
0.0 0.2 GO:0051765 inositol tetrakisphosphate kinase activity(GO:0051765)
0.0 0.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.0 GO:0004939 beta-adrenergic receptor activity(GO:0004939)
0.0 0.1 GO:0051011 microtubule minus-end binding(GO:0051011)
0.0 0.2 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0019870 potassium channel inhibitor activity(GO:0019870)
0.0 0.0 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.0 0.1 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.0 0.0 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 0.1 GO:0097642 calcitonin family receptor activity(GO:0097642)
0.0 0.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.0 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 0.2 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 0.1 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
0.0 0.0 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.0 0.3 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.1 REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Norepinephrine Neurotransmitter Release Cycle
0.0 0.3 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.0 0.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.0 0.2 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 0.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity