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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Mecom

Z-value: 1.81

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Transcription factors associated with Mecom

Gene Symbol	Gene ID	Gene Info
Mecom Ensembl NCBI MGI UniProt	ENSMUSG00000027684.10	MDS1 and EVI1 complex locus

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr3_30506438_30507337	Mecom	2600	0.198314	0.96	2.5e-03	Click!
chr3_30507376_30507724	Mecom	1937	0.249845	0.95	3.1e-03	Click!
chr3_30549571_30549744	Mecom	1649	0.260930	-0.78	7.0e-02	Click!
chr3_30101238_30101422	Mecom	39093	0.156518	-0.77	7.2e-02	Click!
chr3_30015349_30015519	Mecom	1929	0.306530	0.64	1.7e-01	Click!

Activity of the Mecom motif across conditions

Conditions sorted by the z-value of the Mecom motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_108075287_108075438	2.12	Scp2	sterol carrier protein 2, liver	3943	0.17
chr3_152357627_152357783	1.22	Usp33	ubiquitin specific peptidase 33	4193	0.14
chr8_3217015_3217198	1.05	Insr	insulin receptor	24389	0.17
chr5_87499331_87499512	1.03	Ugt2a1	UDP glucuronosyltransferase 2 family, polypeptide A1	8550	0.12
chr16_42947764_42948084	1.03	Ndufs5-ps	NADH:ubiquinone oxidoreductase core subunit S5, pseudogene	7707	0.21
chr11_106728824_106729001	0.99	Pecam1	platelet/endothelial cell adhesion molecule 1	13518	0.12
chr5_66095093_66095575	0.99	Rbm47	RNA binding motif protein 47	2857	0.18
chr2_121439577_121439771	0.97	Ell3	elongation factor RNA polymerase II-like 3	1477	0.18
chr9_77753656_77753905	0.92	Gclc	glutamate-cysteine ligase, catalytic subunit	755	0.58
chr11_120807385_120807536	0.89	Fasn	fatty acid synthase	1145	0.28
chr7_46031049_46031458	0.87	Abcc6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	951	0.41
chr8_46486311_46486711	0.86	Acsl1	acyl-CoA synthetase long-chain family member 1	4455	0.18
chr6_32962622_32962773	0.84	Chchd3	coiled-coil-helix-coiled-coil-helix domain containing 3	65626	0.11
chr5_134436362_134436513	0.84	Gm26340	predicted gene, 26340	12137	0.11
chr17_49429803_49429983	0.82	Gm20540	predicted gene 20540	653	0.65
chr14_76827348_76827510	0.79	Gm48968	predicted gene, 48968	5392	0.22
chr15_3435423_3435589	0.78	Ghr	growth hormone receptor	36138	0.21
chr3_58454505_58454707	0.77	Tsc22d2	TSC22 domain family, member 2	37122	0.13
chr3_89149636_89149787	0.77	Hcn3	hyperpolarization-activated, cyclic nucleotide-gated K+ 3	1503	0.17
chr4_137794057_137794257	0.76	Alpl	alkaline phosphatase, liver/bone/kidney	2073	0.34
chr2_91782501_91782660	0.75	Ambra1	autophagy/beclin 1 regulator 1	9348	0.18
chr4_106354740_106354963	0.74	Usp24	ubiquitin specific peptidase 24	38617	0.13
chr11_94583519_94583672	0.73	Acsf2	acyl-CoA synthetase family member 2	12817	0.11
chr7_144040112_144040314	0.73	Shank2	SH3 and multiple ankyrin repeat domains 2	8949	0.21
chr16_24892958_24893109	0.71	Gm22672	predicted gene, 22672	8860	0.25
chr6_6204143_6204472	0.71	Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	12811	0.23
chr8_122943666_122943817	0.71	Ankrd11	ankyrin repeat domain 11	27754	0.11
chr6_94653423_94653689	0.70	Lrig1	leucine-rich repeats and immunoglobulin-like domains 1	1969	0.38
chr19_55252347_55252717	0.69	Acsl5	acyl-CoA synthetase long-chain family member 5	572	0.74
chr2_117119777_117119942	0.68	Spred1	sprouty protein with EVH-1 domain 1, related sequence	1515	0.45
chr6_124688048_124688642	0.67	Lpcat3	lysophosphatidylcholine acyltransferase 3	13074	0.06
chr14_67053186_67053337	0.67	Ppp2r2a	protein phosphatase 2, regulatory subunit B, alpha	9732	0.17
chr18_39483316_39483539	0.66	Nr3c1	nuclear receptor subfamily 3, group C, member 1	3805	0.31
chr15_6891673_6891824	0.66	Osmr	oncostatin M receptor	16779	0.26
chr9_55214755_55215047	0.64	Fbxo22	F-box protein 22	1238	0.43
chr14_65385019_65385170	0.64	Zfp395	zinc finger protein 395	9701	0.18
chr10_61648098_61648328	0.64	Ppa1	pyrophosphatase (inorganic) 1	339	0.83
chr17_91875617_91875801	0.63	Gm41654	predicted gene, 41654	3570	0.25
chr3_75952417_75952705	0.62	Gm37685	predicted gene, 37685	437	0.81
chr19_25343677_25343828	0.62	Gm34432	predicted gene, 34432	3451	0.3
chr4_76368947_76369220	0.62	Gm11252	predicted gene 11252	24071	0.2
chr8_116404224_116404375	0.61	1700018P08Rik	RIKEN cDNA 1700018P08 gene	47238	0.17
chr4_15267631_15268095	0.61	Tmem64	transmembrane protein 64	2032	0.43
chr18_65223520_65223956	0.61	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	15854	0.15
chr1_119647745_119647910	0.60	Epb41l5	erythrocyte membrane protein band 4.1 like 5	790	0.6
chr16_46848879_46849042	0.60	Gm6912	predicted gene 6912	225238	0.02
chr5_87573106_87573296	0.60	Sult1d1	sulfotransferase family 1D, member 1	4174	0.13
chr4_41331357_41331705	0.59	Gm26084	predicted gene, 26084	14420	0.1
chr16_26698467_26698766	0.59	Il1rap	interleukin 1 receptor accessory protein	23818	0.24
chr9_80672315_80672507	0.58	Gm39380	predicted gene, 39380	37584	0.19
chr8_25603179_25603391	0.58	Nsd3	nuclear receptor binding SET domain protein 3	966	0.35
chr6_14897330_14897481	0.58	Foxp2	forkhead box P2	3944	0.37
chr11_75737051_75737202	0.57	Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	3978	0.19
chr14_14067010_14067161	0.57	Atxn7	ataxin 7	20384	0.17
chr14_11567053_11567226	0.56	Ptprg	protein tyrosine phosphatase, receptor type, G	13558	0.22
chr9_90270049_90270249	0.56	Tbc1d2b	TBC1 domain family, member 2B	620	0.71
chr8_91494941_91495092	0.56	Gm45289	predicted gene 45289	1997	0.25
chr18_58272927_58273088	0.56	Gm25660	predicted gene, 25660	41432	0.19
chr2_32073660_32073977	0.56	Fam78a	family with sequence similarity 78, member A	5534	0.12
chr12_73341772_73342027	0.55	Slc38a6	solute carrier family 38, member 6	2468	0.25
chr12_104355745_104355928	0.54	Serpina3l-ps	serine (or cysteine) peptidase inhibitor, clade A, member 3L, pseudogene	2167	0.21
chr5_122937277_122937753	0.54	Kdm2b	lysine (K)-specific demethylase 2B	10479	0.13
chr4_76350562_76351008	0.54	Ptprd	protein tyrosine phosphatase, receptor type, D	6542	0.27
chr10_71382555_71382706	0.54	Ipmk	inositol polyphosphate multikinase	881	0.56
chr3_32364907_32365337	0.53	Zmat3	zinc finger matrin type 3	338	0.87
chr6_85933884_85934041	0.53	Nat8b-ps	N-acetyltransferase 8B, pseudogene	583	0.52
chr3_138286066_138286462	0.52	Adh1	alcohol dehydrogenase 1 (class I)	8613	0.12
chr19_61226929_61227456	0.52	Csf2ra	colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage)	44	0.96
chr2_75773042_75773329	0.52	Gm13657	predicted gene 13657	4003	0.18
chr6_117009658_117009825	0.51	Gm43929	predicted gene, 43929	27722	0.19
chr2_115758350_115758524	0.51	Meis2	Meis homeobox 2	110430	0.06
chr8_93164567_93164980	0.51	Ces1d	carboxylesterase 1D	5202	0.15
chr5_77460215_77460391	0.50	1700017L05Rik	RIKEN cDNA 1700017L05 gene	5185	0.17
chr2_155470676_155470827	0.50	Ncoa6	nuclear receptor coactivator 6	3055	0.15
chr17_13018717_13018879	0.50	Sod2	superoxide dismutase 2, mitochondrial	8458	0.11
chr2_60122174_60122591	0.50	Gm13620	predicted gene 13620	2714	0.2
chr11_55497781_55497965	0.50	Mir7652	microRNA 7652	3353	0.14
chr19_4600545_4600696	0.50	Pcx	pyruvate carboxylase	6212	0.12
chr13_112308580_112308731	0.50	Ankrd55	ankyrin repeat domain 55	9799	0.17
chr6_90555718_90555877	0.49	Aldh1l1	aldehyde dehydrogenase 1 family, member L1	4949	0.16
chr12_45069728_45070323	0.49	Stxbp6	syntaxin binding protein 6 (amisyn)	4087	0.24
chr7_66388868_66389043	0.49	Lrrk1	leucine-rich repeat kinase 1	605	0.64
chr4_148644834_148645010	0.49	Gm572	predicted gene 572	1605	0.29
chr5_134312402_134312749	0.49	Gtf2i	general transcription factor II I	553	0.67
chr17_13774125_13774292	0.48	Tcte2	t-complex-associated testis expressed 2	12383	0.15
chr4_134926867_134927018	0.48	Rsrp1	arginine/serine rich protein 1	1496	0.34
chr2_70838613_70839186	0.48	Tlk1	tousled-like kinase 1	13171	0.18
chr3_121795871_121796026	0.48	4633401B06Rik	RIKEN cDNA 4633401B06 gene	7376	0.13
chr19_44380608_44380766	0.47	Scd1	stearoyl-Coenzyme A desaturase 1	26003	0.12
chr8_25775115_25775327	0.47	Bag4	BCL2-associated athanogene 4	2361	0.16
chr19_44403240_44403567	0.47	Scd1	stearoyl-Coenzyme A desaturase 1	3287	0.19
chr15_82166714_82166896	0.47	Gm49502	predicted gene, 49502	18711	0.08
chr9_100535718_100535869	0.46	Gm28586	predicted gene 28586	4722	0.16
chr9_40801417_40801568	0.46	Hspa8	heat shock protein 8	31	0.94
chr16_65617781_65617932	0.46	Gm49633	predicted gene, 49633	4437	0.27
chr4_97779759_97779983	0.46	E130114P18Rik	RIKEN cDNA E130114P18 gene	1793	0.32
chr4_132414912_132415080	0.46	Gm25707	predicted gene, 25707	6687	0.1
chr19_36835196_36835389	0.45	Tnks2	tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2	888	0.61
chr3_60046790_60046945	0.45	Aadac	arylacetamide deacetylase	14991	0.15
chr9_51313328_51313479	0.45	1810046K07Rik	RIKEN cDNA 1810046K07 gene	688	0.69
chr6_108456531_108456780	0.45	Itpr1	inositol 1,4,5-trisphosphate receptor 1	2048	0.31
chr3_149090724_149090881	0.44	Gm25127	predicted gene, 25127	61870	0.11
chr5_53470110_53470463	0.44	Rbpj	recombination signal binding protein for immunoglobulin kappa J region	4134	0.24
chr13_40851030_40851206	0.43	Gm35160	predicted gene, 35160	4379	0.12
chr16_13320219_13320378	0.43	Mrtfb	myocardin related transcription factor B	38123	0.17
chr12_40574749_40574900	0.43	Dock4	dedicator of cytokinesis 4	128488	0.05
chr11_110242652_110242881	0.42	Abca6	ATP-binding cassette, sub-family A (ABC1), member 6	9010	0.26
chr6_128843572_128843953	0.42	Gm44066	predicted gene, 44066	591	0.53
chr19_4786678_4786855	0.42	Rbm4	RNA binding motif protein 4	7085	0.08
chr3_58418942_58419336	0.42	Tsc22d2	TSC22 domain family, member 2	1655	0.37
chr6_116068553_116068726	0.42	Tmcc1	transmembrane and coiled coil domains 1	4517	0.2
chr11_28694849_28695038	0.41	2810471M01Rik	RIKEN cDNA 2810471M01 gene	13379	0.17
chr5_66046377_66046556	0.41	Rbm47	RNA binding motif protein 47	8086	0.13
chr5_125483749_125483900	0.40	Gm27551	predicted gene, 27551	4447	0.15
chr2_103594624_103594957	0.40	Abtb2	ankyrin repeat and BTB (POZ) domain containing 2	28480	0.17
chr12_84185436_84185743	0.40	Gm19327	predicted gene, 19327	2217	0.18
chr3_52298742_52298941	0.40	Gm38034	predicted gene, 38034	16600	0.14
chr12_71909107_71909265	0.40	Daam1	dishevelled associated activator of morphogenesis 1	19456	0.21
chr12_87443355_87443540	0.40	Alkbh1	alkB homolog 1, histone H2A dioxygenase	379	0.44
chr17_29717187_29717383	0.39	1810014P07Rik	RIKEN cDNA 1810014P07 gene	213	0.52
chr19_58398099_58398278	0.39	Gfra1	glial cell line derived neurotrophic factor family receptor alpha 1	56278	0.14
chr4_88715181_88715384	0.39	Gm26566	predicted gene, 26566	6523	0.05
chr18_61909540_61909715	0.39	Ablim3	actin binding LIM protein family, member 3	2196	0.31
chr4_55242738_55242936	0.39	Gm12508	predicted gene 12508	11903	0.17
chr4_97779546_97779733	0.39	E130114P18Rik	RIKEN cDNA E130114P18 gene	1561	0.34
chr8_93227828_93228167	0.39	Ces1e	carboxylesterase 1E	1621	0.29
chr17_86494572_86495073	0.39	Prkce	protein kinase C, epsilon	1495	0.46
chr3_97632897_97633210	0.39	Fmo5	flavin containing monooxygenase 5	4170	0.16
chr16_4932467_4932619	0.38	Mgrn1	mahogunin, ring finger 1	4865	0.11
chr4_123990670_123991070	0.38	Gm12902	predicted gene 12902	64636	0.08
chr4_76448425_76449174	0.38	Ptprd	protein tyrosine phosphatase, receptor type, D	1181	0.49
chr16_25879136_25879302	0.38	Gm4524	predicted gene 4524	77256	0.1
chr4_99037726_99038187	0.37	Angptl3	angiopoietin-like 3	4753	0.21
chr2_166027566_166027720	0.37	Ncoa3	nuclear receptor coactivator 3	20275	0.14
chr17_46110701_46110892	0.37	Mrps18a	mitochondrial ribosomal protein S18A	190	0.91
chr6_38827332_38827516	0.37	Hipk2	homeodomain interacting protein kinase 2	9078	0.23
chr19_37439255_37439863	0.37	Hhex	hematopoietically expressed homeobox	2820	0.17
chr19_10065348_10065653	0.36	Fads2	fatty acid desaturase 2	5687	0.14
chr16_26608378_26608529	0.36	Il1rap	interleukin 1 receptor accessory protein	15703	0.26
chr3_151838300_151838467	0.36	Ptgfr	prostaglandin F receptor	753	0.58
chr18_38176749_38176900	0.36	Pcdh1	protocadherin 1	26339	0.12
chr13_9035178_9035364	0.36	Gtpbp4	GTP binding protein 4	39188	0.08
chr16_43277669_43278048	0.36	Gm37946	predicted gene, 37946	30423	0.15
chr1_131501686_131501867	0.36	Srgap2	SLIT-ROBO Rho GTPase activating protein 2	2590	0.21
chr2_167325906_167326068	0.36	B4galt5	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5	12087	0.18
chr17_46505508_46505659	0.36	Cul9	cullin 9	4512	0.12
chr7_45574336_45574519	0.36	Bcat2	branched chain aminotransferase 2, mitochondrial	673	0.29
chr17_46454562_46454932	0.36	Gm5093	predicted gene 5093	14650	0.09
chr14_105253422_105253603	0.36	Gm22290	predicted gene, 22290	3502	0.18
chr2_30413885_30414091	0.35	Gm16323	predicted gene 16323	272	0.54
chr15_6448654_6448821	0.35	C9	complement component 9	3365	0.27
chr2_152240729_152240889	0.35	Csnk2a1	casein kinase 2, alpha 1 polypeptide	13896	0.14
chr13_23574893_23575044	0.35	Gm44359	predicted gene, 44359	115	0.72
chr18_11317026_11317247	0.35	Gata6	GATA binding protein 6	258089	0.02
chr3_51416126_51416308	0.35	Naa15	N(alpha)-acetyltransferase 15, NatA auxiliary subunit	79	0.94
chr12_24614688_24615076	0.35	Gm6969	predicted pseudogene 6969	24128	0.13
chr1_130830297_130830686	0.35	Pigr	polymeric immunoglobulin receptor	1481	0.28
chr9_70234061_70234212	0.34	Myo1e	myosin IE	26768	0.19
chr17_5017691_5017888	0.34	Arid1b	AT rich interactive domain 1B (SWI-like)	21360	0.22
chr6_97304469_97304675	0.34	Frmd4b	FERM domain containing 4B	7808	0.22
chr13_96746192_96746359	0.34	Ankrd31	ankyrin repeat domain 31	1997	0.31
chr10_110708063_110708339	0.34	E2f7	E2F transcription factor 7	37238	0.16
chr6_28482820_28482980	0.34	Snd1	staphylococcal nuclease and tudor domain containing 1	2471	0.22
chr12_30348373_30348544	0.33	Sntg2	syntrophin, gamma 2	9225	0.26
chr11_48838500_48838661	0.33	Trim7	tripartite motif-containing 7	66	0.94
chr4_148143306_148143457	0.33	Mad2l2	MAD2 mitotic arrest deficient-like 2	1409	0.24
chr10_108170850_108171005	0.33	Ppp1r12a	protein phosphatase 1, regulatory subunit 12A	8527	0.25
chr17_15372798_15372972	0.33	Dll1	delta like canonical Notch ligand 1	1054	0.47
chr15_93398531_93398907	0.33	Pphln1	periphilin 1	255	0.63
chr15_82635338_82635489	0.33	Gm27463	predicted gene, 27463	6588	0.08
chr7_73543304_73543467	0.33	Chd2	chromodomain helicase DNA binding protein 2	1555	0.24
chr14_73255473_73255646	0.33	Rb1	RB transcriptional corepressor 1	8762	0.17
chr10_33866082_33866287	0.32	Sult3a1	sulfotransferase family 3A, member 1	2249	0.21
chr11_98206684_98206835	0.32	Cdk12	cyclin-dependent kinase 12	3424	0.14
chr4_45799507_45799658	0.32	Aldh1b1	aldehyde dehydrogenase 1 family, member B1	461	0.76
chr5_54043709_54043896	0.32	Stim2	stromal interaction molecule 2	30935	0.2
chr10_29302371_29302533	0.32	Echdc1	enoyl Coenzyme A hydratase domain containing 1	10714	0.13
chr12_111375253_111375404	0.32	Cdc42bpb	CDC42 binding protein kinase beta	2291	0.23
chr6_50587768_50588064	0.32	4921507P07Rik	RIKEN cDNA 4921507P07 gene	8716	0.09
chr4_144900352_144900520	0.32	Dhrs3	dehydrogenase/reductase (SDR family) member 3	7217	0.22
chr16_94571169_94571354	0.32	Dyrk1a	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1a	354	0.88
chr7_26916759_26917069	0.32	Cyp2a21-ps	cytochrome P450, family 2, subfamily a, polypeptide 21, pseudogene	467	0.74
chr11_51739157_51739308	0.32	Gm25291	predicted gene, 25291	1310	0.37
chr3_52257597_52258053	0.31	Foxo1	forkhead box O1	10511	0.12
chr4_53095991_53096266	0.31	Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	55202	0.11
chr2_69205518_69205715	0.31	Spc25	SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae)	401	0.81
chr9_9180190_9180363	0.31	Gm16833	predicted gene, 16833	56012	0.14
chr10_61444973_61445124	0.31	Gm48086	predicted gene, 48086	5669	0.11
chr19_44458524_44458675	0.31	Gm35406	predicted gene, 35406	5582	0.16
chr13_101779442_101779645	0.31	Pik3r1	phosphoinositide-3-kinase regulatory subunit 1	11326	0.2
chr7_118698593_118698744	0.31	Gde1	glycerophosphodiester phosphodiesterase 1	6712	0.13
chr17_32946227_32946412	0.31	Cyp4f13	cytochrome P450, family 4, subfamily f, polypeptide 13	1016	0.36
chr2_15064726_15064962	0.31	Arl5b	ADP-ribosylation factor-like 5B	3295	0.18
chr11_120695384_120695739	0.31	Aspscr1	alveolar soft part sarcoma chromosome region, candidate 1 (human)	6251	0.07
chr13_115090984_115091155	0.30	Pelo	pelota mRNA surveillance and ribosome rescue factor	883	0.44
chr1_63115073_63115446	0.30	Ino80dos	INO80 complex subunit D, opposite strand	519	0.42
chr19_34524861_34525231	0.30	Lipa	lysosomal acid lipase A	2365	0.2
chr2_167422512_167422688	0.30	Slc9a8	solute carrier family 9 (sodium/hydrogen exchanger), member 8	858	0.6
chr17_84268442_84268633	0.30	Gm24492	predicted gene, 24492	19210	0.18
chr17_65577307_65577458	0.30	Gm49866	predicted gene, 49866	16606	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecom

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.1	0.4	GO:1903334	positive regulation of protein folding(GO:1903334)
0.1	0.4	GO:0060847	endothelial cell fate specification(GO:0060847)
0.1	0.4	GO:0009826	unidimensional cell growth(GO:0009826)
0.1	0.1	GO:0006549	isoleucine metabolic process(GO:0006549)
0.1	0.5	GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus(GO:0097011)
0.1	0.3	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.3	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.1	0.3	GO:0072338	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1	0.5	GO:0010746	regulation of plasma membrane long-chain fatty acid transport(GO:0010746)
0.1	0.2	GO:0032474	otolith morphogenesis(GO:0032474)
0.1	0.5	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.1	0.2	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1	0.5	GO:0051409	response to nitrosative stress(GO:0051409)
0.1	0.3	GO:0072602	interleukin-4 secretion(GO:0072602)
0.1	0.3	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.1	0.1	GO:0006068	ethanol catabolic process(GO:0006068)
0.1	0.3	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1	0.2	GO:0071799	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.1	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.1	0.3	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.1	0.2	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.1	0.3	GO:0010917	negative regulation of mitochondrial membrane potential(GO:0010917)
0.1	0.2	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.1	0.3	GO:0044789	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.1	0.3	GO:0017196	N-terminal peptidyl-methionine acetylation(GO:0017196)
0.1	0.2	GO:0000957	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.1	GO:0090365	regulation of mRNA modification(GO:0090365)
0.0	0.3	GO:0006307	DNA dealkylation involved in DNA repair(GO:0006307)
0.0	0.2	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.0	0.1	GO:0052490	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.0	0.2	GO:1903599	positive regulation of mitophagy(GO:1903599)
0.0	0.1	GO:0002949	tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.0	0.1	GO:1901492	positive regulation of lymphangiogenesis(GO:1901492)
0.0	0.5	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	0.2	GO:0046477	glycosylceramide catabolic process(GO:0046477)
0.0	0.2	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.1	GO:0043988	histone H3-S28 phosphorylation(GO:0043988)
0.0	0.1	GO:0052203	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0	0.1	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
0.0	0.1	GO:0061010	gall bladder development(GO:0061010)
0.0	0.2	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:0006210	pyrimidine nucleobase catabolic process(GO:0006208) thymine catabolic process(GO:0006210) thymine metabolic process(GO:0019859)
0.0	0.2	GO:0019087	transformation of host cell by virus(GO:0019087)
0.0	0.1	GO:0002337	B-1a B cell differentiation(GO:0002337)
0.0	0.1	GO:0002386	immune response in mucosal-associated lymphoid tissue(GO:0002386)
0.0	0.1	GO:2000370	positive regulation of clathrin-mediated endocytosis(GO:2000370)
0.0	0.1	GO:0044027	hypermethylation of CpG island(GO:0044027)
0.0	0.1	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.4	GO:0014733	regulation of skeletal muscle adaptation(GO:0014733)
0.0	0.1	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.2	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.0	0.1	GO:0051987	positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.0	0.1	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.0	0.1	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0	0.2	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:1903677	regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0	0.1	GO:1902488	cholangiocyte apoptotic process(GO:1902488) regulation of cholangiocyte apoptotic process(GO:1904192) negative regulation of cholangiocyte apoptotic process(GO:1904193)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:2000467	positive regulation of glycogen (starch) synthase activity(GO:2000467)
0.0	0.1	GO:0036438	maintenance of lens transparency(GO:0036438)
0.0	0.3	GO:0048742	regulation of skeletal muscle fiber development(GO:0048742)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.2	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.1	GO:0032513	negative regulation of protein phosphatase type 2B activity(GO:0032513)
0.0	0.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.1	GO:2000048	negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
0.0	0.4	GO:0051923	sulfation(GO:0051923)
0.0	0.1	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.0	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.3	GO:0036035	osteoclast development(GO:0036035)
0.0	0.1	GO:0055093	response to increased oxygen levels(GO:0036296) response to hyperoxia(GO:0055093)
0.0	0.1	GO:0006777	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.0	GO:0003162	atrioventricular node development(GO:0003162)
0.0	0.1	GO:0071763	nuclear membrane organization(GO:0071763)
0.0	0.1	GO:0070885	negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.0	0.1	GO:0072310	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.0	GO:2000809	positive regulation of synaptic vesicle clustering(GO:2000809)
0.0	0.1	GO:0045200	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.1	GO:0009642	response to light intensity(GO:0009642)
0.0	0.2	GO:0042637	catagen(GO:0042637)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:0006369	termination of RNA polymerase II transcription(GO:0006369)
0.0	0.0	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.1	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.1	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.1	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.3	GO:0015858	nucleoside transport(GO:0015858)
0.0	0.0	GO:0060137	maternal process involved in parturition(GO:0060137)
0.0	0.1	GO:0072592	oxygen metabolic process(GO:0072592)
0.0	0.1	GO:0006678	glucosylceramide metabolic process(GO:0006678)
0.0	0.0	GO:0038027	apolipoprotein A-I-mediated signaling pathway(GO:0038027)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.1	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
0.0	0.0	GO:0044004	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.0	GO:2000836	androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
0.0	0.1	GO:0009972	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.0	GO:0010694	positive regulation of alkaline phosphatase activity(GO:0010694)
0.0	0.1	GO:0042795	snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.0	0.1	GO:1903999	negative regulation of eating behavior(GO:1903999)
0.0	0.1	GO:0002439	chronic inflammatory response to antigenic stimulus(GO:0002439)
0.0	0.0	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0	0.1	GO:0010387	COP9 signalosome assembly(GO:0010387)
0.0	0.1	GO:0090241	negative regulation of histone H4 acetylation(GO:0090241)
0.0	0.3	GO:0090312	positive regulation of protein deacetylation(GO:0090312)
0.0	0.1	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.2	GO:0007183	SMAD protein complex assembly(GO:0007183)
0.0	0.1	GO:2000210	positive regulation of anoikis(GO:2000210)
0.0	0.2	GO:0060346	bone trabecula formation(GO:0060346)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.1	GO:0046881	positive regulation of follicle-stimulating hormone secretion(GO:0046881)
0.0	0.1	GO:0086013	membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0	0.1	GO:0032055	negative regulation of translation in response to stress(GO:0032055)
0.0	0.1	GO:1901525	regulation of macromitophagy(GO:1901524) negative regulation of macromitophagy(GO:1901525)
0.0	0.5	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	0.1	GO:0002155	thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0	0.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.3	GO:0032958	inositol phosphate biosynthetic process(GO:0032958)
0.0	0.1	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.0	0.0	GO:0002904	positive regulation of B cell apoptotic process(GO:0002904)
0.0	0.0	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.0	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.0	GO:0090259	regulation of retinal ganglion cell axon guidance(GO:0090259)
0.0	0.1	GO:0042448	progesterone metabolic process(GO:0042448)
0.0	0.0	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.1	GO:0035457	cellular response to interferon-alpha(GO:0035457)
0.0	0.2	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.1	GO:0043569	negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.0	0.0	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.0	0.1	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0001672	regulation of chromatin assembly or disassembly(GO:0001672)
0.0	0.1	GO:0008354	germ cell migration(GO:0008354)
0.0	0.1	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.1	GO:0010571	positive regulation of nuclear cell cycle DNA replication(GO:0010571)
0.0	0.0	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.2	GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.0	0.3	GO:0001958	endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.0	0.1	GO:0050904	diapedesis(GO:0050904)
0.0	0.0	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.1	GO:0002538	arachidonic acid metabolite production involved in inflammatory response(GO:0002538)
0.0	0.1	GO:0045714	regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045714)
0.0	0.1	GO:0003406	retinal pigment epithelium development(GO:0003406)
0.0	0.1	GO:0070995	NADPH oxidation(GO:0070995)
0.0	0.0	GO:1904861	excitatory synapse assembly(GO:1904861)
0.0	0.1	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.0	0.2	GO:0071625	vocalization behavior(GO:0071625)
0.0	0.2	GO:0006359	regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.0	0.1	GO:0060396	growth hormone receptor signaling pathway(GO:0060396) cellular response to growth hormone stimulus(GO:0071378)
0.0	0.0	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.0	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.1	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.0	0.0	GO:0090310	negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.1	GO:0035405	histone-threonine phosphorylation(GO:0035405)
0.0	0.1	GO:0048478	replication fork protection(GO:0048478)
0.0	0.1	GO:2000271	positive regulation of fibroblast apoptotic process(GO:2000271)
0.0	0.0	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.0	0.1	GO:1902744	negative regulation of lamellipodium organization(GO:1902744)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0045908	negative regulation of vasodilation(GO:0045908)
0.0	0.2	GO:0010758	regulation of macrophage chemotaxis(GO:0010758)
0.0	0.2	GO:0060074	synapse maturation(GO:0060074)
0.0	0.2	GO:0035855	megakaryocyte development(GO:0035855)
0.0	0.2	GO:0070536	protein K63-linked deubiquitination(GO:0070536)
0.0	0.0	GO:0090110	cargo loading into COPII-coated vesicle(GO:0090110)
0.0	0.1	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.0	GO:0060744	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.1	GO:0006297	nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0	0.1	GO:0042760	very long-chain fatty acid catabolic process(GO:0042760)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.2	GO:0008053	mitochondrial fusion(GO:0008053)
0.0	0.0	GO:0070375	ERK5 cascade(GO:0070375)
0.0	0.1	GO:0097094	craniofacial suture morphogenesis(GO:0097094)
0.0	0.0	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.0	GO:0031947	negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947)
0.0	0.0	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.0	0.1	GO:0006878	cellular copper ion homeostasis(GO:0006878)
0.0	0.0	GO:0003223	ventricular compact myocardium morphogenesis(GO:0003223)
0.0	0.1	GO:0002072	optic cup morphogenesis involved in camera-type eye development(GO:0002072)
0.0	0.0	GO:2000304	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0	0.0	GO:0080009	mRNA methylation(GO:0080009)
0.0	0.0	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.0	GO:0036135	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.0	GO:0097527	necroptotic signaling pathway(GO:0097527)
0.0	0.0	GO:0060066	oviduct development(GO:0060066)
0.0	0.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.1	GO:0070475	rRNA base methylation(GO:0070475)
0.0	0.1	GO:2000096	positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.0	0.0	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.0	GO:0055099	response to high density lipoprotein particle(GO:0055099)
0.0	0.0	GO:0006971	hypotonic response(GO:0006971)
0.0	0.0	GO:0016259	selenocysteine metabolic process(GO:0016259)
0.0	0.1	GO:0009162	deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0	0.0	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.0	GO:1990791	dorsal root ganglion development(GO:1990791)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:0007220	Notch receptor processing(GO:0007220)
0.0	0.2	GO:0048026	positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.0	0.1	GO:0033004	negative regulation of mast cell activation(GO:0033004)
0.0	0.1	GO:0045943	positive regulation of transcription from RNA polymerase I promoter(GO:0045943)
0.0	0.1	GO:0032287	peripheral nervous system myelin maintenance(GO:0032287)
0.0	0.0	GO:2000259	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.1	0.2	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	0.4	GO:0043202	lysosomal lumen(GO:0043202)
0.1	0.3	GO:0031262	Ndc80 complex(GO:0031262)
0.1	0.2	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.1	0.2	GO:0005899	insulin receptor complex(GO:0005899)
0.1	0.3	GO:0031415	NatA complex(GO:0031415)
0.0	0.2	GO:0031298	replication fork protection complex(GO:0031298)
0.0	0.3	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.2	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:0000408	EKC/KEOPS complex(GO:0000408)
0.0	0.1	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.0	0.2	GO:0005883	neurofilament(GO:0005883)
0.0	0.1	GO:0005968	Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0	0.1	GO:0001739	sex chromatin(GO:0001739)
0.0	0.1	GO:0036396	MIS complex(GO:0036396)
0.0	0.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.2	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)
0.0	0.1	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0061617	MICOS complex(GO:0061617)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0005956	protein kinase CK2 complex(GO:0005956)
0.0	0.2	GO:1990023	mitotic spindle midzone(GO:1990023)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0000835	ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0042629	mast cell granule(GO:0042629)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	0.3	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.1	GO:0090576	RNA polymerase III transcription factor complex(GO:0090576)
0.0	0.1	GO:0005664	origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0	0.1	GO:0070688	MLL5-L complex(GO:0070688)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0042825	TAP complex(GO:0042825)
0.0	0.0	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.0	GO:0033647	host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.0	0.1	GO:0001527	microfibril(GO:0001527)
0.0	0.1	GO:0097431	mitotic spindle pole(GO:0097431)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.2	GO:0000145	exocyst(GO:0000145)
0.0	0.3	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0	0.0	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.0	0.1	GO:0042622	photoreceptor outer segment membrane(GO:0042622)
0.0	0.0	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.2	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.1	GO:0005869	dynactin complex(GO:0005869)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.2	0.5	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.1	0.4	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.1	0.7	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.1	0.2	GO:0004771	sterol esterase activity(GO:0004771)
0.1	0.3	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.1	0.3	GO:0035276	ethanol binding(GO:0035276)
0.1	0.3	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.1	0.3	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	0.3	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.1	0.2	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1	0.4	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.1	0.2	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1	0.2	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.1	0.3	GO:1990239	steroid hormone binding(GO:1990239)
0.1	0.2	GO:0030984	kininogen binding(GO:0030984)
0.0	0.2	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.6	GO:0016595	glutamate binding(GO:0016595)
0.0	0.2	GO:0008853	exodeoxyribonuclease III activity(GO:0008853)
0.0	0.3	GO:0008440	inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
0.0	0.2	GO:0004062	aryl sulfotransferase activity(GO:0004062)
0.0	0.2	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.0	0.2	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0035175	histone kinase activity (H3-S10 specific)(GO:0035175)
0.0	0.1	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.2	GO:0003688	DNA replication origin binding(GO:0003688)
0.0	0.3	GO:0004596	peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0	0.2	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.1	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.0	0.2	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.1	GO:0043515	kinetochore binding(GO:0043515)
0.0	0.1	GO:0004663	Rab geranylgeranyltransferase activity(GO:0004663)
0.0	0.4	GO:0048156	tau protein binding(GO:0048156)
0.0	0.2	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.3	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.1	GO:0071074	eukaryotic initiation factor eIF2 binding(GO:0071074)
0.0	0.2	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.8	GO:0050253	retinyl-palmitate esterase activity(GO:0050253)
0.0	0.0	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0	0.0	GO:0005350	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0	0.1	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0031779	melanocortin receptor binding(GO:0031779) type 3 melanocortin receptor binding(GO:0031781) type 4 melanocortin receptor binding(GO:0031782)
0.0	0.2	GO:0004955	prostaglandin receptor activity(GO:0004955)
0.0	0.1	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.3	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.0	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.1	GO:0004735	pyrroline-5-carboxylate reductase activity(GO:0004735)
0.0	0.2	GO:0016840	carbon-nitrogen lyase activity(GO:0016840)
0.0	0.2	GO:0015385	sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0	0.1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.1	GO:1904288	BAT3 complex binding(GO:1904288)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.1	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.1	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0008190	eukaryotic initiation factor 4E binding(GO:0008190)
0.0	0.0	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.2	GO:0017160	Ral GTPase binding(GO:0017160)
0.0	0.1	GO:0004045	aminoacyl-tRNA hydrolase activity(GO:0004045)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0042500	aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0	0.1	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.0	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:0008467	[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.0	0.1	GO:0042577	lipid phosphatase activity(GO:0042577)
0.0	0.1	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.2	GO:0008409	5'-3' exonuclease activity(GO:0008409)
0.0	0.1	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.0	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.0	0.1	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.1	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.0	0.1	GO:0031544	peptidyl-proline 3-dioxygenase activity(GO:0031544)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0048185	activin binding(GO:0048185)
0.0	0.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.2	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0043762	3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0	0.0	GO:1990188	euchromatin binding(GO:1990188)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.0	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.0	GO:0035650	AP-1 adaptor complex binding(GO:0035650)
0.0	0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.1	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.0	0.3	GO:0051019	mitogen-activated protein kinase binding(GO:0051019)
0.0	0.0	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.3	GO:0001103	RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0	0.1	GO:0005499	vitamin D binding(GO:0005499)
0.0	0.0	GO:0051033	nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.0	0.1	GO:0043008	ATP-dependent protein binding(GO:0043008)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.0	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.0	GO:0051022	Rho GDP-dissociation inhibitor binding(GO:0051022)
0.0	0.0	GO:0016774	phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.0	0.1	GO:0008432	JUN kinase binding(GO:0008432)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0002054	nucleobase binding(GO:0002054)
0.0	0.1	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	0.0	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.0	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
0.0	0.0	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:0018636	phenanthrene 9,10-monooxygenase activity(GO:0018636)
0.0	0.0	GO:0070698	type I activin receptor binding(GO:0070698)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.6	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.1	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.3	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.7	PID TGFBR PATHWAY	TGF-beta receptor signaling
0.3	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.1	SA PROGRAMMED CELL DEATH	Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.5	PID PS1 PATHWAY	Presenilin action in Notch and Wnt signaling
0.2	SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES	Genes related to the insulin receptor pathway
0.4	PID IL1 PATHWAY	IL1-mediated signaling events
0.1	PID IGF1 PATHWAY	IGF1 pathway
0.2	SIG PIP3 SIGNALING IN B LYMPHOCYTES	Genes related to PIP3 signaling in B lymphocytes
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.2	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	0.8	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.0	0.1	REACTOME ACYL CHAIN REMODELLING OF PG	Genes involved in Acyl chain remodelling of PG
0.0	0.6	REACTOME CYTOSOLIC TRNA AMINOACYLATION	Genes involved in Cytosolic tRNA aminoacylation
0.0	0.2	REACTOME PROSTANOID LIGAND RECEPTORS	Genes involved in Prostanoid ligand receptors
0.0	0.7	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	0.0	REACTOME IL 2 SIGNALING	Genes involved in Interleukin-2 signaling
0.0	0.3	REACTOME SIGNALING BY NOTCH2	Genes involved in Signaling by NOTCH2
0.0	0.6	REACTOME IL RECEPTOR SHC SIGNALING	Genes involved in Interleukin receptor SHC signaling
0.0	0.3	REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION	Genes involved in GABA synthesis, release, reuptake and degradation
0.0	0.1	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.3	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.2	REACTOME NOTCH HLH TRANSCRIPTION PATHWAY	Genes involved in Notch-HLH transcription pathway
0.0	0.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.2	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.2	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.0	0.2	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.0	0.4	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0	0.4	REACTOME TGF BETA RECEPTOR SIGNALING ACTIVATES SMADS	Genes involved in TGF-beta receptor signaling activates SMADs
0.0	0.1	REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION	Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.0	0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.0	0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.0	0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.2	REACTOME SHC RELATED EVENTS	Genes involved in SHC-related events
0.0	0.4	REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION	Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0	0.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.1	REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK	Genes involved in Negative regulation of the PI3K/AKT network
0.0	0.2	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.0	0.1	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.4	REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D	Genes involved in Metabolism of steroid hormones and vitamins A and D
0.0	0.1	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.2	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.1	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.1	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.0	0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.2	REACTOME PHOSPHORYLATION OF THE APC C	Genes involved in Phosphorylation of the APC/C
0.0	0.3	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification

Results for Mecom

Z-value: 1.81

Motif logo

Transcription factors associated with Mecom

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Mecom motif across conditions

Conditions sorted by the z-value of the Mecom motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Mecom

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: