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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Msx3

Z-value: 1.66

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Transcription factors associated with Msx3

Gene Symbol	Gene ID	Gene Info
Msx3 Ensembl NCBI MGI UniProt	ENSMUSG00000025469.9	Msx3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Msx3	chr7_140049374_140049526	361	0.740301	-0.55	2.5e-01	Click!
Msx3	chr7_140058149_140058300	9135	0.087534	-0.22	6.8e-01	Click!
Msx3	chr7_140063217_140063374	14206	0.081201	-0.12	8.2e-01	Click!
Msx3	chr7_140061314_140061474	12305	0.083391	0.07	8.9e-01	Click!

Activity of the Msx3 motif across conditions

Conditions sorted by the z-value of the Msx3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr9_20730600_20730850	1.56	Olfm2	olfactomedin 2	2496	0.23
chr11_83271635_83271942	1.52	Gm23444	predicted gene, 23444	290	0.8
chr8_24445565_24445716	1.44	Gm44620	predicted gene 44620	1457	0.34
chr11_109733399_109733703	1.22	Fam20a	family with sequence similarity 20, member A	11272	0.17
chr18_7847563_7847725	1.17	Gm50027	predicted gene, 50027	2709	0.23
chr6_35874026_35874908	1.10	Gm43442	predicted gene 43442	52244	0.17
chr17_83938813_83938978	1.09	Gm23905	predicted gene, 23905	8693	0.12
chr6_126033747_126033913	1.06	Ntf3	neurotrophin 3	131130	0.05
chr18_8939044_8939213	1.00	Gm37148	predicted gene, 37148	10893	0.24
chr10_108350464_108350766	0.95	Gm23105	predicted gene, 23105	13050	0.19
chr19_44027305_44027461	0.95	Cyp2c23	cytochrome P450, family 2, subfamily c, polypeptide 23	1816	0.28
chr13_106525577_106525787	0.94	Gm48216	predicted gene, 48216	6135	0.23
chr10_52294294_52294477	0.92	Gm6627	predicted gene 6627	49272	0.09
chr12_118887325_118887612	0.90	Abcb5	ATP-binding cassette, sub-family B (MDR/TAP), member 5	3291	0.3
chr9_33001470_33001748	0.89	Gm27166	predicted gene 27166	30182	0.17
chr13_101967419_101967852	0.87	Gm17832	predicted gene, 17832	47215	0.17
chr5_43157097_43157384	0.84	Gm42552	predicted gene 42552	8913	0.21
chr14_69628830_69628981	0.83	Gm27177	predicted gene 27177	11369	0.11
chr4_132129267_132129447	0.80	Oprd1	opioid receptor, delta 1	15129	0.1
chr17_5012388_5012845	0.79	Arid1b	AT rich interactive domain 1B (SWI-like)	16187	0.23
chr15_38661347_38661720	0.79	Atp6v1c1	ATPase, H+ transporting, lysosomal V1 subunit C1	400	0.79
chr2_22589828_22590052	0.78	Gm13340	predicted gene 13340	293	0.68
chr5_110596813_110596964	0.77	Galnt9	polypeptide N-acetylgalactosaminyltransferase 9	6633	0.15
chr11_111605518_111605669	0.76	Gm11676	predicted gene 11676	7713	0.32
chr9_66414274_66414486	0.76	Gm28379	predicted gene 28379	6261	0.21
chr18_64325483_64325793	0.75	St8sia3os	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand	8068	0.16
chr7_45264516_45264678	0.74	Slc6a16	solute carrier family 6, member 16	3553	0.09
chr12_69759378_69759543	0.74	Mir681	microRNA 681	4484	0.15
chr1_4859119_4859327	0.73	Tcea1	transcription elongation factor A (SII) 1	1185	0.36
chr2_178711802_178711999	0.72	Cdh26	cadherin-like 26	251270	0.02
chr11_108782497_108782676	0.71	Cep112	centrosomal protein 112	30381	0.16
chr1_34439675_34439854	0.71	Imp4	IMP4, U3 small nucleolar ribonucleoprotein	87	0.49
chr8_76913299_76913495	0.71	Nr3c2	nuclear receptor subfamily 3, group C, member 2	5125	0.24
chr15_31279226_31279377	0.70	Gm49296	predicted gene, 49296	2788	0.19
chrX_140387482_140387633	0.70	Frmpd3	FERM and PDZ domain containing 3	5586	0.23
chr3_116409014_116409188	0.70	Cdc14a	CDC14 cell division cycle 14A	3613	0.2
chr15_99865164_99865320	0.70	Lima1	LIM domain and actin binding 1	9429	0.08
chr13_92533605_92533774	0.69	Zfyve16	zinc finger, FYVE domain containing 16	2821	0.27
chr6_17255791_17255960	0.69	Cav2	caveolin 2	25310	0.17
chr7_66740464_66740653	0.69	Gm10623	predicted gene 10623	2754	0.19
chr4_142088876_142089143	0.68	Tmem51os1	Tmem51 opposite strand 1	4153	0.16
chr3_28736802_28736989	0.67	1700112D23Rik	RIKEN cDNA 1700112D23 gene	5345	0.16
chr15_77773367_77773546	0.66	Myh9	myosin, heavy polypeptide 9, non-muscle	3677	0.15
chr15_82290409_82290560	0.66	Septin3	septin 3	6054	0.09
chr13_58058115_58058280	0.65	Mir874	microRNA 874	34997	0.13
chr5_105830536_105830687	0.65	Lrrc8d	leucine rich repeat containing 8D	6100	0.14
chr8_81366726_81366902	0.64	Inpp4b	inositol polyphosphate-4-phosphatase, type II	24252	0.21
chr3_58894660_58894811	0.64	Clrn1	clarin 1	9395	0.2
chr19_27411429_27411595	0.64	Pum3	pumilio RNA-binding family member 3	752	0.7
chr12_35294499_35294705	0.63	Gm44396	predicted gene, 44396	14289	0.25
chr12_85818362_85818513	0.63	Erg28	ergosterol biosynthesis 28	3813	0.2
chr9_90303778_90304052	0.63	Gm30849	predicted gene, 30849	115	0.96
chr3_65357881_65358061	0.63	Kcnab1	potassium voltage-gated channel, shaker-related subfamily, beta member 1	4204	0.18
chr2_69061493_69062160	0.62	Gm38377	predicted gene, 38377	43730	0.11
chr11_87449212_87449363	0.62	Rnu3b3	U3B small nuclear RNA 3	660	0.48
chr2_75202592_75202875	0.62	Gm13653	predicted gene 13653	10456	0.15
chr2_169634592_169634925	0.61	Tshz2	teashirt zinc finger family member 2	1082	0.55
chr5_90465676_90466047	0.61	Alb	albumin	3161	0.2
chr14_61361356_61361514	0.61	Ebpl	emopamil binding protein-like	996	0.42
chr4_97099326_97100044	0.60	Gm27521	predicted gene, 27521	182665	0.03
chr1_174921018_174921617	0.60	Grem2	gremlin 2, DAN family BMP antagonist	502	0.88
chr9_123530850_123531001	0.60	Sacm1l	SAC1 suppressor of actin mutations 1-like (yeast)	1043	0.5
chr1_52597389_52597548	0.60	Gm5527	predicted gene 5527	12950	0.13
chr12_73584095_73584268	0.60	Prkch	protein kinase C, eta	615	0.73
chrX_100447058_100447240	0.59	Awat2	acyl-CoA wax alcohol acyltransferase 2	4432	0.18
chr11_86361937_86362118	0.59	Med13	mediator complex subunit 13	4425	0.24
chr18_37949922_37950073	0.58	Hdac3	histone deacetylase 3	4433	0.1
chr11_100330372_100330542	0.56	Gast	gastrin	3950	0.09
chr4_35148195_35148566	0.56	Ifnk	interferon kappa	3676	0.22
chr1_65186286_65186491	0.56	Idh1	isocitrate dehydrogenase 1 (NADP+), soluble	50	0.79
chr1_60862632_60862783	0.56	Gm38137	predicted gene, 38137	17631	0.12
chr14_121469692_121469843	0.55	Gm33299	predicted gene, 33299	14005	0.17
chr10_127355627_127355790	0.55	Inhbe	inhibin beta-E	1297	0.23
chr17_55749906_55750061	0.55	Adgre4	adhesion G protein-coupled receptor E4	1	0.97
chr2_132595408_132595654	0.54	AU019990	expressed sequence AU019990	2664	0.22
chr12_26976640_26976824	0.54	Gm9866	predicted gene 9866	138263	0.05
chr4_141718181_141718503	0.54	Ddi2	DNA-damage inducible protein 2	5077	0.14
chr18_35681549_35681863	0.54	Dnajc18	DnaJ heat shock protein family (Hsp40) member C18	5037	0.1
chr19_26754124_26754675	0.53	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	799	0.69
chr9_61370295_61371248	0.53	Gm10655	predicted gene 10655	856	0.53
chr5_114985285_114985436	0.52	1810017P11Rik	RIKEN cDNA 1810017P11 gene	9904	0.09
chr12_106477969_106478140	0.52	Gm3191	predicted gene 3191	18904	0.17
chr3_133765600_133766533	0.52	Gm6135	prediticted gene 6135	25438	0.2
chr11_94370063_94370224	0.51	Abcc3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	2220	0.26
chr14_19839858_19840045	0.51	D14Ertd670e	DNA segment, Chr 14, ERATO Doi 670, expressed	1026	0.48
chr19_23024753_23025259	0.51	Gm50136	predicted gene, 50136	36448	0.17
chr3_85550361_85550689	0.51	Gm42812	predicted gene 42812	2864	0.24
chr8_128687947_128688299	0.51	Itgb1	integrin beta 1 (fibronectin receptor beta)	2253	0.29
chr7_145056434_145056606	0.50	Gm45181	predicted gene 45181	106476	0.05
chr2_120170818_120170979	0.50	Ehd4	EH-domain containing 4	16292	0.15
chr18_46336206_46336490	0.50	4930415P13Rik	RIKEN cDNA 4930415P13 gene	4081	0.17
chr13_115595390_115595557	0.50	Gm6035	predicted gene 6035	65701	0.14
chr11_70713419_70713657	0.49	Mir6925	microRNA 6925	7548	0.08
chr1_185836743_185836921	0.49	Gm9722	predicted gene 9722	42053	0.18
chr17_63343186_63343351	0.49	Gm17228	predicted gene 17228	4142	0.22
chr8_93154464_93154622	0.48	Gm45910	predicted gene 45910	427	0.78
chr14_45453135_45453314	0.48	Gm34250	predicted gene, 34250	6151	0.13
chr1_73931861_73932066	0.48	Tns1	tensin 1	1152	0.54
chr13_58999542_58999699	0.48	Gm34245	predicted gene, 34245	78676	0.08
chr17_8343197_8343376	0.48	Prr18	proline rich 18	2547	0.17
chr15_64334950_64335143	0.48	Gm10926	predicted gene 10926	6029	0.2
chr18_20187452_20187603	0.48	Dsg1c	desmoglein 1 gamma	59813	0.12
chr18_56607212_56607383	0.48	Gm50283	predicted gene, 50283	6362	0.14
chr1_24042012_24042182	0.48	Fam135a	family with sequence similarity 135, member A	13011	0.18
chr2_132134128_132134319	0.48	Gm14051	predicted gene 14051	10310	0.16
chr13_14192509_14192814	0.47	Arid4b	AT rich interactive domain 4B (RBP1-like)	1484	0.37
chr10_115337191_115337351	0.47	Tmem19	transmembrane protein 19	11793	0.14
chr14_60635934_60636102	0.47	Spata13	spermatogenesis associated 13	1263	0.52
chr3_149170339_149170514	0.47	Gm42647	predicted gene 42647	39845	0.16
chr15_61562347_61562502	0.47	Gm49498	predicted gene, 49498	18241	0.28
chr14_30351980_30352170	0.47	Cacna1d	calcium channel, voltage-dependent, L type, alpha 1D subunit	889	0.57
chr2_131180305_131180466	0.47	Cenpb	centromere protein B	318	0.78
chr6_4009646_4009797	0.47	Gng11	guanine nucleotide binding protein (G protein), gamma 11	5817	0.17
chr4_149453846_149453997	0.47	Rbp7	retinol binding protein 7, cellular	497	0.65
chr9_55233053_55233204	0.46	Nrg4	neuregulin 4	9333	0.17
chr7_46767478_46767782	0.46	Hps5	HPS5, biogenesis of lysosomal organelles complex 2 subunit 2	833	0.4
chr3_41465297_41465458	0.46	Gm40040	predicted gene, 40040	16508	0.13
chr9_8003099_8003325	0.46	Yap1	yes-associated protein 1	545	0.68
chr9_119341051_119341435	0.46	Acaa1a	acetyl-Coenzyme A acyltransferase 1A	51	0.65
chr7_84112155_84112947	0.45	Cemip	cell migration inducing protein, hyaluronan binding	26049	0.14
chr18_10251145_10251313	0.44	Gm5686	predicted gene 5686	10978	0.14
chr10_53753298_53753451	0.44	Fam184a	family with sequence similarity 184, member A	2251	0.35
chr16_70563529_70563695	0.44	Gbe1	glucan (1,4-alpha-), branching enzyme 1	2618	0.36
chr11_34998043_34998214	0.44	Gm25799	predicted gene, 25799	99111	0.07
chr2_82446048_82446229	0.44	A130030D18Rik	RIKEN cDNA A130030D18 gene	53936	0.14
chr13_16269739_16270144	0.43	Gm48491	predicted gene, 48491	7897	0.23
chr6_31148929_31149080	0.43	Gm37728	predicted gene, 37728	1585	0.28
chr2_48816834_48817005	0.43	Acvr2a	activin receptor IIA	2810	0.3
chr19_43511120_43511314	0.43	Got1	glutamic-oxaloacetic transaminase 1, soluble	4648	0.14
chr16_27391982_27392165	0.43	Ccdc50	coiled-coil domain containing 50	2105	0.33
chr16_26248335_26248499	0.42	Cldn1	claudin 1	112377	0.07
chr17_36032663_36032990	0.42	H2-T23	histocompatibility 2, T region locus 23	29	0.92
chr2_132143179_132143352	0.42	Gm14051	predicted gene 14051	1268	0.37
chr10_68248229_68248529	0.42	Arid5b	AT rich interactive domain 5B (MRF1-like)	30342	0.19
chr3_118507933_118508602	0.42	Gm37773	predicted gene, 37773	17884	0.14
chr10_9902050_9902213	0.42	Gm46210	predicted gene, 46210	818	0.46
chr13_78124273_78124441	0.42	Gm18990	predicted gene, 18990	3287	0.19
chr10_41627379_41627538	0.41	Ccdc162	coiled-coil domain containing 162	14621	0.15
chr15_34493251_34493646	0.41	Rida	reactive intermediate imine deaminase A homolog	1723	0.21
chr9_122814663_122814835	0.41	Tcaim	T cell activation inhibitor, mitochondrial	9146	0.12
chr3_138231897_138232387	0.41	Adh7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	4091	0.14
chr16_25351479_25351642	0.41	Tprg	transformation related protein 63 regulated	64739	0.14
chr3_116967199_116967673	0.41	4930455H04Rik	RIKEN cDNA 4930455H04 gene	831	0.45
chr10_70924491_70924642	0.41	Bicc1	BicC family RNA binding protein 1	23923	0.12
chr5_34380236_34380602	0.41	Fam193a	family with sequence homology 193, member A	10486	0.14
chr2_77563772_77563946	0.41	Zfp385b	zinc finger protein 385B	1879	0.47
chr2_122081842_122082023	0.40	Spg11	SPG11, spatacsin vesicle trafficking associated	36364	0.11
chr12_3811591_3811763	0.40	Dnmt3a	DNA methyltransferase 3A	4517	0.2
chr19_43767883_43768034	0.40	Cutc	cutC copper transporter	3085	0.18
chr7_123124873_123125354	0.40	Tnrc6a	trinucleotide repeat containing 6a	857	0.66
chr17_26024045_26024196	0.40	Rab11fip3	RAB11 family interacting protein 3 (class II)	2260	0.16
chr1_72145974_72146125	0.39	Gm4319	predicted gene 4319	24048	0.15
chr11_16883025_16883203	0.39	Egfr	epidermal growth factor receptor	4964	0.23
chr9_64457749_64457913	0.39	Megf11	multiple EGF-like-domains 11	43505	0.16
chr19_12005901_12006348	0.39	Olfr1421-ps1	olfactory receptor 1421, pseudogene 1	14051	0.08
chr3_94338287_94338715	0.39	Gm43743	predicted gene 43743	3169	0.1
chr6_71823720_71824038	0.38	Mrpl35	mitochondrial ribosomal protein L35	69	0.95
chr3_61217316_61217479	0.38	Gm37719	predicted gene, 37719	74049	0.1
chr19_36735506_36735662	0.38	Ppp1r3c	protein phosphatase 1, regulatory subunit 3C	1069	0.56
chr2_63580816_63581021	0.38	Gm23503	predicted gene, 23503	148724	0.05
chr4_105215829_105216004	0.38	Plpp3	phospholipid phosphatase 3	58569	0.15
chr7_111726929_111727297	0.38	Galnt18	polypeptide N-acetylgalactosaminyltransferase 18	52864	0.15
chr12_35294940_35295100	0.38	Gm44396	predicted gene, 44396	13871	0.25
chr17_84385788_84385950	0.38	Gm24722	predicted gene, 24722	5560	0.22
chr1_136229022_136229181	0.37	Inava	innate immunity activator	918	0.4
chr1_133251724_133252043	0.37	Gm19461	predicted gene, 19461	2409	0.23
chr11_83703751_83703986	0.37	Wfdc17	WAP four-disulfide core domain 17	123	0.9
chr1_43066043_43066369	0.37	Tgfbrap1	transforming growth factor, beta receptor associated protein 1	5273	0.14
chr4_65532386_65532616	0.37	Trim32	tripartite motif-containing 32	72485	0.14
chr6_41044443_41044618	0.37	2210010C04Rik	RIKEN cDNA 2210010C04 gene	9021	0.07
chr11_102040134_102040466	0.37	Cd300lg	CD300 molecule like family member G	1209	0.28
chr17_8974900_8975051	0.37	1700010I14Rik	RIKEN cDNA 1700010I14 gene	13358	0.23
chr12_57514709_57514889	0.37	Gm2568	predicted gene 2568	5825	0.17
chr2_142767278_142767429	0.37	Gm22310	predicted gene, 22310	19543	0.24
chr3_145621208_145621546	0.37	Znhit6	zinc finger, HIT type 6	25509	0.15
chr11_7153168_7153348	0.37	Adcy1	adenylate cyclase 1	6624	0.21
chr4_11865116_11865283	0.36	Gm25002	predicted gene, 25002	83688	0.07
chr7_49397440_49397604	0.36	Nav2	neuron navigator 2	32801	0.18
chr9_79213455_79213848	0.36	Gm47499	predicted gene, 47499	11644	0.17
chrX_74270256_74270420	0.36	Rpl10	ribosomal protein L10	474	0.52
chr4_116689870_116690150	0.36	Prdx1	peroxiredoxin 1	2698	0.15
chr9_77662986_77663137	0.36	Klhl31	kelch-like 31	26561	0.14
chr11_29719333_29719653	0.36	Rtn4	reticulon 4	930	0.53
chr10_108074024_108074345	0.36	Gm47999	predicted gene, 47999	68248	0.12
chr15_97031052_97031203	0.36	Slc38a4	solute carrier family 38, member 4	84	0.98
chr15_10273020_10273171	0.36	Prlr	prolactin receptor	23535	0.21
chr11_60537500_60537667	0.36	Alkbh5	alkB homolog 5, RNA demethylase	395	0.72
chr12_14302401_14302552	0.36	Gm16497	predicted gene 16497	40920	0.19
chr15_77208076_77208227	0.36	Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	4715	0.18
chr3_138426007_138426180	0.36	Adh4	alcohol dehydrogenase 4 (class II), pi polypeptide	10598	0.13
chr5_9056138_9056296	0.36	Gm40264	predicted gene, 40264	21093	0.14
chr6_50176334_50176508	0.36	Mpp6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	3879	0.27
chr15_61398964_61399115	0.36	Gm24696	predicted gene, 24696	41035	0.19
chr6_121963215_121963471	0.36	Mug2	murinoglobulin 2	43418	0.12
chr8_115984246_115984444	0.35	Gm45733	predicted gene 45733	12274	0.31
chr14_64331778_64331949	0.35	Msra	methionine sulfoxide reductase A	85085	0.09
chr1_24612181_24612351	0.35	Gm28439	predicted gene 28439	144	0.72
chr6_94814990_94815159	0.35	Gm7833	predicted gene 7833	5456	0.15
chr8_123032866_123033108	0.35	Ankrd11	ankyrin repeat domain 11	9033	0.11
chr4_8361870_8362071	0.35	Gm37386	predicted gene, 37386	92277	0.08

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Msx3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0060300	regulation of cytokine activity(GO:0060300)
0.1	0.4	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.1	0.4	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.4	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.1	0.3	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.1	0.5	GO:0046487	glyoxylate metabolic process(GO:0046487)
0.1	0.1	GO:0010166	wax biosynthetic process(GO:0010025) wax metabolic process(GO:0010166)
0.1	0.3	GO:0035513	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.1	0.2	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.1	0.5	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.1	0.2	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.1	0.2	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.1	0.2	GO:0043134	hindgut contraction(GO:0043133) regulation of hindgut contraction(GO:0043134)
0.1	0.3	GO:1902459	positive regulation of stem cell population maintenance(GO:1902459)
0.1	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.1	0.1	GO:1904502	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.1	0.2	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.1	0.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.1	0.3	GO:0042663	regulation of endodermal cell fate specification(GO:0042663)
0.1	0.2	GO:0072566	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.0	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.0	0.2	GO:0003383	apical constriction(GO:0003383)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.3	GO:0035811	negative regulation of urine volume(GO:0035811)
0.0	0.2	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.3	GO:0035336	long-chain fatty-acyl-CoA metabolic process(GO:0035336)
0.0	0.2	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.1	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.6	GO:0035278	miRNA mediated inhibition of translation(GO:0035278)
0.0	0.3	GO:0002591	positive regulation of antigen processing and presentation of peptide antigen via MHC class I(GO:0002591)
0.0	0.1	GO:0010911	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.1	GO:2000173	negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.4	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.1	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.2	GO:0042713	sperm ejaculation(GO:0042713)
0.0	0.1	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:0001907	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.1	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.0	0.2	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:0007403	glial cell fate determination(GO:0007403)
0.0	0.2	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:1901492	positive regulation of lymphangiogenesis(GO:1901492)
0.0	0.1	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.1	GO:0051295	establishment of meiotic spindle localization(GO:0051295)
0.0	0.1	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.1	GO:0034627	'de novo' NAD biosynthetic process(GO:0034627)
0.0	0.2	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0043974	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.1	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.0	0.1	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.1	GO:1900019	regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.0	0.1	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.4	GO:0072673	lamellipodium morphogenesis(GO:0072673)
0.0	0.2	GO:0000022	mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.0	0.0	GO:0035511	oxidative DNA demethylation(GO:0035511)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.0	GO:0046101	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.3	GO:0046838	phosphorylated carbohydrate dephosphorylation(GO:0046838)
0.0	0.0	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.1	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0	0.3	GO:0046856	phosphatidylinositol dephosphorylation(GO:0046856)
0.0	0.2	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.1	GO:0042706	eye photoreceptor cell fate commitment(GO:0042706) photoreceptor cell fate commitment(GO:0046552)
0.0	0.1	GO:0007023	post-chaperonin tubulin folding pathway(GO:0007023)
0.0	0.0	GO:0050923	regulation of negative chemotaxis(GO:0050923)
0.0	0.1	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.1	GO:1902513	regulation of organelle transport along microtubule(GO:1902513)
0.0	0.1	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0	0.1	GO:0007181	transforming growth factor beta receptor complex assembly(GO:0007181)
0.0	0.1	GO:0090230	regulation of centromere complex assembly(GO:0090230)
0.0	0.1	GO:0001514	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.1	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.1	GO:0061144	alveolar secondary septum development(GO:0061144)
0.0	0.0	GO:0046504	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.1	GO:0048254	snoRNA localization(GO:0048254)
0.0	0.4	GO:0044783	G1 DNA damage checkpoint(GO:0044783)
0.0	0.1	GO:0034116	positive regulation of heterotypic cell-cell adhesion(GO:0034116)
0.0	0.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.1	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.2	GO:0046040	IMP metabolic process(GO:0046040)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.1	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.0	0.1	GO:0060398	regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0	0.1	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.2	GO:0071157	negative regulation of cell cycle arrest(GO:0071157)
0.0	0.3	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.1	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.0	0.2	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:0006532	aspartate biosynthetic process(GO:0006532)
0.0	0.0	GO:2001187	positive regulation of CD8-positive, alpha-beta T cell activation(GO:2001187)
0.0	0.1	GO:0060020	Bergmann glial cell differentiation(GO:0060020)
0.0	0.1	GO:0071318	cellular response to ATP(GO:0071318)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.2	GO:0051386	regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:2001274	negative regulation of glucose import in response to insulin stimulus(GO:2001274)
0.0	0.0	GO:0090071	negative regulation of ribosome biogenesis(GO:0090071)
0.0	0.0	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.1	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.2	GO:0071257	cellular response to electrical stimulus(GO:0071257)
0.0	0.1	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0018214	peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214)
0.0	0.0	GO:0002430	complement receptor mediated signaling pathway(GO:0002430)
0.0	0.3	GO:0045780	positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0	0.0	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0	0.0	GO:1902075	cellular response to salt(GO:1902075)
0.0	0.2	GO:0015693	magnesium ion transport(GO:0015693)
0.0	0.1	GO:0038003	opioid receptor signaling pathway(GO:0038003)
0.0	0.0	GO:0061643	chemorepulsion of axon(GO:0061643)
0.0	0.0	GO:0090259	regulation of retinal ganglion cell axon guidance(GO:0090259)
0.0	0.0	GO:1901856	negative regulation of cellular respiration(GO:1901856)
0.0	0.0	GO:0040033	negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.0	0.0	GO:0042504	tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519)
0.0	0.0	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.1	GO:0048935	peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.0	0.0	GO:0036215	response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109)
0.0	0.1	GO:0060023	soft palate development(GO:0060023)
0.0	0.2	GO:0010663	positive regulation of striated muscle cell apoptotic process(GO:0010663) positive regulation of cardiac muscle cell apoptotic process(GO:0010666)
0.0	0.0	GO:0009826	unidimensional cell growth(GO:0009826)
0.0	0.1	GO:0016188	synaptic vesicle maturation(GO:0016188)
0.0	0.1	GO:0015808	L-alanine transport(GO:0015808)
0.0	0.1	GO:0044789	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0	0.0	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.1	GO:0042997	negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
0.0	0.2	GO:0006883	cellular sodium ion homeostasis(GO:0006883)
0.0	0.0	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.0	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.0	0.0	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0031507	heterochromatin assembly(GO:0031507)
0.0	0.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.0	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.0	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.1	GO:0048012	hepatocyte growth factor receptor signaling pathway(GO:0048012)
0.0	0.0	GO:0030046	parallel actin filament bundle assembly(GO:0030046)
0.0	0.1	GO:0002023	reduction of food intake in response to dietary excess(GO:0002023)
0.0	0.1	GO:0099515	actin filament-based transport(GO:0099515)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0071404	cellular response to low-density lipoprotein particle stimulus(GO:0071404)
0.0	0.1	GO:0043031	negative regulation of macrophage activation(GO:0043031)
0.0	0.1	GO:0007288	sperm axoneme assembly(GO:0007288)
0.0	0.0	GO:0002314	germinal center B cell differentiation(GO:0002314)
0.0	0.0	GO:0072318	clathrin coat disassembly(GO:0072318)
0.0	0.0	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:1990168	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.0	GO:0048633	positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0	0.1	GO:0071380	cellular response to prostaglandin E stimulus(GO:0071380)
0.0	0.0	GO:0032077	positive regulation of deoxyribonuclease activity(GO:0032077)
0.0	0.1	GO:0009446	putrescine biosynthetic process(GO:0009446)
0.0	0.0	GO:0030886	negative regulation of myeloid dendritic cell activation(GO:0030886)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.0	GO:0031296	B cell costimulation(GO:0031296)
0.0	0.1	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.1	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.0	GO:0006041	glucosamine metabolic process(GO:0006041)
0.0	0.0	GO:0001997	positive regulation of the force of heart contraction by epinephrine-norepinephrine(GO:0001997) positive regulation of the force of heart contraction by chemical signal(GO:0003099)
0.0	0.0	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.1	GO:1903817	negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.0	0.1	GO:0061000	negative regulation of dendritic spine development(GO:0061000)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.1	GO:0032494	response to peptidoglycan(GO:0032494)
0.0	0.1	GO:0006622	protein targeting to lysosome(GO:0006622)
0.0	0.4	GO:0009250	glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0	0.4	GO:0010761	fibroblast migration(GO:0010761)
0.0	0.1	GO:0014028	notochord formation(GO:0014028)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0	0.0	GO:2000383	regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
0.0	0.0	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	0.3	GO:0042832	defense response to protozoan(GO:0042832)
0.0	0.0	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.1	GO:0006654	phosphatidic acid biosynthetic process(GO:0006654)
0.0	0.0	GO:0097477	lateral motor column neuron migration(GO:0097477)
0.0	0.1	GO:0009435	NAD biosynthetic process(GO:0009435)
0.0	0.0	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.0	0.3	GO:0015988	energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.0	0.1	GO:0007016	cytoskeletal anchoring at plasma membrane(GO:0007016)
0.0	0.0	GO:0000966	RNA 5'-end processing(GO:0000966)
0.0	0.0	GO:0010796	regulation of multivesicular body size(GO:0010796)
0.0	0.1	GO:0046007	negative regulation of activated T cell proliferation(GO:0046007)
0.0	0.1	GO:0006662	glycerol ether metabolic process(GO:0006662)
0.0	0.0	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.1	GO:0007076	mitotic chromosome condensation(GO:0007076)
0.0	0.0	GO:1904706	negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.0	0.0	GO:2001166	regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
0.0	0.0	GO:1903116	positive regulation of actin filament-based movement(GO:1903116)
0.0	0.0	GO:0015747	urate transport(GO:0015747)
0.0	0.1	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0034457	Mpp10 complex(GO:0034457)
0.1	0.6	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.1	0.2	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.1	0.2	GO:0033269	internode region of axon(GO:0033269)
0.1	0.2	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.1	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:0031084	BLOC-2 complex(GO:0031084)
0.0	0.1	GO:0097413	Lewy body(GO:0097413)
0.0	0.6	GO:0016514	SWI/SNF complex(GO:0016514)
0.0	0.1	GO:1990635	proximal dendrite(GO:1990635)
0.0	0.1	GO:0097629	extrinsic component of omegasome membrane(GO:0097629)
0.0	0.3	GO:0020005	symbiont-containing vacuole membrane(GO:0020005)
0.0	0.2	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.1	GO:0097513	myosin II filament(GO:0097513)
0.0	0.4	GO:0042612	MHC class I protein complex(GO:0042612)
0.0	0.9	GO:0032281	AMPA glutamate receptor complex(GO:0032281)
0.0	0.2	GO:0042587	glycogen granule(GO:0042587)
0.0	0.2	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.2	GO:0031209	SCAR complex(GO:0031209)
0.0	0.1	GO:0010009	cytoplasmic side of endosome membrane(GO:0010009)
0.0	0.1	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.1	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0	0.2	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0045179	apical cortex(GO:0045179)
0.0	0.0	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.1	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.1	GO:0030478	actin cap(GO:0030478)
0.0	0.1	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.3	GO:0030057	desmosome(GO:0030057)
0.0	0.1	GO:0017059	serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.3	GO:0030137	COPI-coated vesicle(GO:0030137)
0.0	0.1	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.1	GO:0017101	aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0	0.1	GO:0030689	Noc complex(GO:0030689)
0.0	0.1	GO:0034991	nuclear meiotic cohesin complex(GO:0034991)
0.0	0.4	GO:0031941	filamentous actin(GO:0031941)
0.0	0.0	GO:0032010	phagolysosome(GO:0032010)
0.0	0.1	GO:0070419	nonhomologous end joining complex(GO:0070419)
0.0	0.2	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.0	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	0.0	GO:0071203	WASH complex(GO:0071203)
0.0	0.0	GO:0002178	palmitoyltransferase complex(GO:0002178)
0.0	0.2	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.0	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.6	GO:0000932	cytoplasmic mRNA processing body(GO:0000932)
0.0	0.0	GO:0097443	sorting endosome(GO:0097443)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0060091	kinocilium(GO:0060091)
0.0	0.1	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.1	0.3	GO:0030519	snoRNP binding(GO:0030519)
0.1	0.4	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.1	0.3	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.1	0.4	GO:0003696	satellite DNA binding(GO:0003696)
0.1	0.3	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.1	0.4	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.1	0.2	GO:0097016	L27 domain binding(GO:0097016)
0.1	0.5	GO:0036122	BMP binding(GO:0036122)
0.1	0.2	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.1	0.3	GO:0015562	efflux transmembrane transporter activity(GO:0015562)
0.1	0.1	GO:0035673	oligopeptide transmembrane transporter activity(GO:0035673)
0.1	0.2	GO:0004346	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1	0.2	GO:0098821	BMP receptor activity(GO:0098821)
0.1	0.7	GO:0008553	hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.1	0.2	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.0	0.1	GO:0034596	phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596)
0.0	0.2	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.2	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.3	GO:0004438	phosphatidylinositol-3-phosphatase activity(GO:0004438)
0.0	0.2	GO:0019960	C-X3-C chemokine binding(GO:0019960)
0.0	0.2	GO:0015093	ferrous iron transmembrane transporter activity(GO:0015093)
0.0	0.3	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.4	GO:0030881	beta-2-microglobulin binding(GO:0030881)
0.0	0.1	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.3	GO:0019841	retinol binding(GO:0019841)
0.0	0.1	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.1	GO:0042392	sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.0	0.2	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.0	GO:0035514	DNA demethylase activity(GO:0035514)
0.0	0.1	GO:0050897	cobalt ion binding(GO:0050897)
0.0	0.9	GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0	0.2	GO:0000150	recombinase activity(GO:0000150)
0.0	0.1	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	0.0	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.3	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0	0.6	GO:0051990	(R)-2-hydroxyglutarate dehydrogenase activity(GO:0051990)
0.0	0.1	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.1	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:0016308	1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
0.0	0.2	GO:0043522	leucine zipper domain binding(GO:0043522)
0.0	0.0	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.3	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0	0.2	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.1	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.1	GO:0055131	C3HC4-type RING finger domain binding(GO:0055131)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:1901474	L-histidine transmembrane transporter activity(GO:0005290) azole transporter activity(GO:0045118) azole transmembrane transporter activity(GO:1901474)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.1	GO:0031748	D1 dopamine receptor binding(GO:0031748)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.0	GO:0016778	diphosphotransferase activity(GO:0016778)
0.0	0.2	GO:0004622	lysophospholipase activity(GO:0004622)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.3	GO:0019825	oxygen binding(GO:0019825)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.1	GO:0005024	transforming growth factor beta-activated receptor activity(GO:0005024)
0.0	0.0	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.1	GO:0034046	poly(G) binding(GO:0034046)
0.0	0.0	GO:0042134	rRNA primary transcript binding(GO:0042134)
0.0	0.1	GO:0016892	endoribonuclease activity, producing 3'-phosphomonoesters(GO:0016892)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0002046	opsin binding(GO:0002046)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.6	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0	0.1	GO:0022858	L-alanine transmembrane transporter activity(GO:0015180) alanine transmembrane transporter activity(GO:0022858)
0.0	0.2	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)
0.0	0.1	GO:0008097	5S rRNA binding(GO:0008097)
0.0	0.1	GO:0051959	dynein light intermediate chain binding(GO:0051959)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.4	GO:0001105	RNA polymerase II transcription coactivator activity(GO:0001105)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.0	GO:0052827	inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity(GO:0030351) inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity(GO:0030352) inositol pentakisphosphate phosphatase activity(GO:0052827)
0.0	0.2	GO:0015095	magnesium ion transmembrane transporter activity(GO:0015095)
0.0	0.1	GO:0005166	neurotrophin p75 receptor binding(GO:0005166)
0.0	0.1	GO:0019534	toxin transporter activity(GO:0019534)
0.0	0.1	GO:0003828	alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity(GO:0003828)
0.0	0.0	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.1	GO:0001094	TFIID-class transcription factor binding(GO:0001094)
0.0	0.0	GO:0046923	ER retention sequence binding(GO:0046923)
0.0	0.1	GO:0008889	glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.0	0.1	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.0	GO:0034739	histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.0	0.2	GO:0003746	translation elongation factor activity(GO:0003746)
0.0	0.1	GO:0043140	ATP-dependent 3'-5' DNA helicase activity(GO:0043140)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.4	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.5	PID PRL SIGNALING EVENTS PATHWAY	Signaling events mediated by PRL
0.8	PID TXA2PATHWAY	Thromboxane A2 receptor signaling
0.2	PID ALK1 PATHWAY	ALK1 signaling events
0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.1	ST PAC1 RECEPTOR PATHWAY	PAC1 Receptor Pathway
0.1	PID VEGF VEGFR PATHWAY	VEGF and VEGFR signaling network
0.2	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.1	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.3	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.4	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.1	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.8	REACTOME SIGNALING BY BMP	Genes involved in Signaling by BMP
0.1	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.6	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.6	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.2	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.3	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.4	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.3	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.4	REACTOME EFFECTS OF PIP2 HYDROLYSIS	Genes involved in Effects of PIP2 hydrolysis
0.2	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
0.2	REACTOME GLYCOPROTEIN HORMONES	Genes involved in Glycoprotein hormones
0.3	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.3	REACTOME ENOS ACTIVATION AND REGULATION	Genes involved in eNOS activation and regulation
0.1	REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	Genes involved in p75NTR recruits signalling complexes
0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.5	REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE	Genes involved in Amino acid transport across the plasma membrane
0.4	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.1	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	REACTOME SIGNALLING BY NGF	Genes involved in Signalling by NGF
0.1	REACTOME VEGF LIGAND RECEPTOR INTERACTIONS	Genes involved in VEGF ligand-receptor interactions
0.3	REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS	Genes involved in Thrombin signalling through proteinase activated receptors (PARs)
0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.2	REACTOME ELONGATION ARREST AND RECOVERY	Genes involved in Elongation arrest and recovery
0.2	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling