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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Nfatc4

Z-value: 0.34

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Transcription factors associated with Nfatc4

Gene Symbol	Gene ID	Gene Info
Nfatc4 Ensembl NCBI MGI UniProt	ENSMUSG00000023411.5	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr14_55838433_55838623	Nfatc4	8259	0.090845	0.78	6.6e-02	Click!
chr14_55822593_55822771	Nfatc4	462	0.651782	-0.46	3.6e-01	Click!
chr14_55822818_55822969	Nfatc4	251	0.833439	0.24	6.5e-01	Click!
chr14_55829023_55829187	Nfatc4	364	0.740165	-0.11	8.3e-01	Click!

Activity of the Nfatc4 motif across conditions

Conditions sorted by the z-value of the Nfatc4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_93624235_93624413	0.10	Gm15622	predicted gene 15622	1058	0.48
chr3_83006212_83006467	0.09	Fgg	fibrinogen gamma chain	1385	0.32
chr6_118478658_118478809	0.09	Zfp9	zinc finger protein 9	587	0.69
chr4_97008802_97008953	0.07	Gm27521	predicted gene, 27521	91857	0.09
chr7_80559132_80559287	0.07	Blm	Bloom syndrome, RecQ like helicase	24090	0.13
chr5_145863264_145863516	0.07	Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	13301	0.16
chr3_18463182_18463725	0.07	Gm30667	predicted gene, 30667	2199	0.33
chr18_64334411_64334587	0.07	St8sia3os	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand	793	0.6
chr12_8506611_8506851	0.07	5033421B08Rik	RIKEN cDNA 5033421B08 gene	4470	0.17
chr5_128522783_128522934	0.07	Gm42499	predicted gene 42499	2637	0.23
chr1_121350895_121351046	0.06	2210011K15Rik	RIKEN cDNA 2210011K15 gene	8930	0.16
chr1_72173165_72173339	0.06	Mreg	melanoregulin	39055	0.11
chr2_67974374_67974909	0.06	Gm37964	predicted gene, 37964	76045	0.1
chr11_54587035_54587213	0.06	Rapgef6	Rap guanine nucleotide exchange factor (GEF) 6	9022	0.22
chr1_43827020_43827171	0.06	Uxs1	UDP-glucuronate decarboxylase 1	79	0.97
chr3_5235852_5236031	0.05	Zfhx4	zinc finger homeodomain 4	5731	0.22
chr10_14705733_14705924	0.05	Nmbr	neuromedin B receptor	201	0.57
chr9_65308324_65308479	0.05	Clpx	caseinolytic mitochondrial matrix peptidase chaperone subunit	1751	0.2
chr6_52577798_52578135	0.05	Gm44445	predicted gene, 44445	17414	0.13
chr1_162549290_162549454	0.05	Eef1aknmt	EEF1A lysine and N-terminal methyltransferase	821	0.61
chr6_27671661_27671812	0.05	Gm26310	predicted gene, 26310	3649	0.38
chr16_23102640_23102802	0.05	Eif4a2	eukaryotic translation initiation factor 4A2	4723	0.07
chr9_62335758_62335958	0.05	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	5435	0.21
chr18_34374027_34374186	0.05	Reep5	receptor accessory protein 5	36	0.97
chr6_123539742_123540032	0.05	Gm22722	predicted gene, 22722	145	0.94
chr4_53198055_53198206	0.05	4930412L05Rik	RIKEN cDNA 4930412L05 gene	19431	0.17
chr4_97838379_97838530	0.05	Nfia	nuclear factor I/A	41665	0.17
chr2_177839201_177839672	0.05	Gm14325	predicted gene 14325	882	0.56
chr6_123424383_123424683	0.05	Vmn2r-ps31	vomeronasal 2, receptor, pseudogene 31	91	0.59
chr4_148160291_148160511	0.05	Fbxo44	F-box protein 44	81	0.68
chr2_177498894_177499115	0.04	Gm14403	predicted gene 14403	689	0.65
chr5_25227061_25227222	0.04	E130116L18Rik	RIKEN cDNA E130116L18 gene	3988	0.18
chr9_70890743_70891063	0.04	Gm3436	predicted pseudogene 3436	38327	0.14
chr2_155091972_155092151	0.04	Gm45609	predicted gene 45609	3683	0.17
chr13_23298661_23298830	0.04	Gm11333	predicted gene 11333	696	0.46
chr11_83913932_83914083	0.04	Ddx52	DEAD (Asp-Glu-Ala-Asp) box polypeptide 52	28055	0.14
chr11_87991621_87991895	0.04	Dynll2	dynein light chain LC8-type 2	4225	0.16
chr6_38144181_38144332	0.04	D630045J12Rik	RIKEN cDNA D630045J12 gene	3118	0.22
chr12_71042601_71042779	0.04	Arid4a	AT rich interactive domain 4A (RBP1-like)	5651	0.18
chr5_37952218_37952372	0.04	Gm40289	predicted gene, 40289	31398	0.16
chr19_55266477_55266642	0.04	Acsl5	acyl-CoA synthetase long-chain family member 5	6311	0.18
chr12_26444164_26444328	0.04	Gm47799	predicted gene, 47799	7427	0.14
chr6_31253045_31253249	0.04	2210408F21Rik	RIKEN cDNA 2210408F21 gene	24701	0.14
chr9_76273523_76273711	0.04	Gm27234	predicted gene 27234	45960	0.14
chr19_4786093_4786325	0.04	Rbm4	RNA binding motif protein 4	7642	0.08
chr3_79849200_79849377	0.04	Tmem144	transmembrane protein 144	3480	0.21
chr1_195014918_195015345	0.04	9630010A21Rik	RIKEN cDNA 9630010A21 gene	1385	0.22
chr14_62883124_62883275	0.04	n-R5s47	nuclear encoded rRNA 5S 47	13485	0.13
chr18_35278082_35278245	0.04	Gm50146	predicted gene, 50146	14134	0.16
chr9_95568845_95568996	0.04	Paqr9	progestin and adipoQ receptor family member IX	9263	0.13
chr4_33245946_33246487	0.04	Pnrc1	proline-rich nuclear receptor coactivator 1	1359	0.39
chr7_136820396_136820744	0.04	Gm9347	predicted gene 9347	9661	0.26
chr2_166972459_166972619	0.04	Stau1	staufen double-stranded RNA binding protein 1	4232	0.15
chr15_57468422_57468573	0.04	Slc22a22	solute carrier family 22 (organic cation transporter), member 22	9128	0.21
chr1_172988114_172988265	0.04	Olfr16	olfactory receptor 16	31421	0.13
chr11_3144349_3144521	0.04	Sfi1	Sfi1 homolog, spindle assembly associated (yeast)	1921	0.21
chr17_81375771_81376164	0.04	Gm50044	predicted gene, 50044	5134	0.28
chr11_31785587_31785738	0.04	D630024D03Rik	RIKEN cDNA D630024D03 gene	38811	0.15
chr14_59442931_59443277	0.04	Cab39l	calcium binding protein 39-like	2123	0.24
chr8_59870347_59870498	0.04	4930470O06Rik	RIKEN cDNA 4930470O06 gene	44773	0.2
chr18_56756491_56756863	0.04	Gm15345	predicted gene 15345	13040	0.18
chr6_48677382_48677533	0.03	Gimap9	GTPase, IMAP family member 9	54	0.93
chr3_116934960_116935115	0.03	Gm42892	predicted gene 42892	9293	0.14
chr6_5256423_5256653	0.03	Pon3	paraoxonase 3	252	0.91
chr5_104374044_104374195	0.03	Mepe	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	48790	0.1
chr7_63887410_63887577	0.03	Gm27252	predicted gene 27252	9040	0.15
chr7_16591375_16591549	0.03	Gm29443	predicted gene 29443	22362	0.09
chr15_6237986_6238213	0.03	Dab2	disabled 2, mitogen-responsive phosphoprotein	61689	0.11
chr10_94199177_94199540	0.03	Ndufa12	NADH:ubiquinone oxidoreductase subunit A12	321	0.87
chr4_49407628_49408150	0.03	Acnat2	acyl-coenzyme A amino acid N-acyltransferase 2	262	0.88
chr4_135728255_135728588	0.03	Il22ra1	interleukin 22 receptor, alpha 1	249	0.89
chr1_67162712_67162908	0.03	Cps1	carbamoyl-phosphate synthetase 1	39784	0.16
chr13_81315073_81315331	0.03	Adgrv1	adhesion G protein-coupled receptor V1	27634	0.22
chr5_88693031_88693182	0.03	Grsf1	G-rich RNA sequence binding factor 1	16935	0.14
chr1_67190099_67190250	0.03	Gm15668	predicted gene 15668	59026	0.11
chr11_86347511_86347911	0.03	Med13	mediator complex subunit 13	9891	0.21
chr9_86355672_86355847	0.03	Gm16202	predicted gene 16202	39075	0.18
chr4_95586493_95586698	0.03	Fggy	FGGY carbohydrate kinase domain containing	320	0.9
chr7_114066134_114066326	0.03	Gm45615	predicted gene 45615	20668	0.22
chr2_128377797_128377975	0.03	Morrbid	myeloid RNA regulator of BCL2L11 induced cell death	25079	0.18
chr6_128523521_128524414	0.03	Pzp	PZP, alpha-2-macroglobulin like	2736	0.13
chr4_53011559_53011710	0.03	Nipsnap3b	nipsnap homolog 3B	246	0.9
chr13_105088917_105089088	0.03	Nt5el	5' nucleotidase, ecto-like	6880	0.25
chr10_44002186_44002407	0.03	Gm10812	predicted gene 10812	1858	0.29
chr18_63689863_63690014	0.03	Txnl1	thioredoxin-like 1	2384	0.27
chr14_109874316_109874480	0.03	Gm25901	predicted gene, 25901	8785	0.3
chr5_36557509_36557955	0.03	Tbc1d14	TBC1 domain family, member 14	6324	0.17
chr2_27626035_27626261	0.03	Rxra	retinoid X receptor alpha	50292	0.12
chr18_16797289_16797482	0.03	Cdh2	cadherin 2	11077	0.2
chr11_4822321_4822472	0.03	Nf2	neurofibromin 2	2000	0.29
chr10_128918530_128918929	0.03	Rdh5	retinol dehydrogenase 5	24	0.94
chr19_12598432_12598680	0.03	Gm4952	predicted gene 4952	1418	0.23
chr10_21158162_21158313	0.03	Myb	myeloblastosis oncogene	1592	0.3
chr19_55260197_55260377	0.03	Acsl5	acyl-CoA synthetase long-chain family member 5	6918	0.18
chr17_27805546_27805714	0.03	Ilrun	inflammation and lipid regulator with UBA-like and NBR1-like domains	14822	0.11
chr14_57998520_57998724	0.03	Micu2	mitochondrial calcium uptake 2	576	0.5
chr18_12761990_12762141	0.03	Osbpl1a	oxysterol binding protein-like 1A	5072	0.16
chr12_111819707_111819858	0.03	Zfyve21	zinc finger, FYVE domain containing 21	3526	0.14
chr10_54046292_54046454	0.03	Gm47917	predicted gene, 47917	17438	0.19
chr6_13280975_13281131	0.03	AC121573.1	predicted 725	17308	0.23
chr6_14897753_14897997	0.03	Foxp2	forkhead box P2	3474	0.38
chr4_147426052_147426209	0.03	Gm13161	predicted gene 13161	17341	0.12
chr7_59230441_59230601	0.03	Ube3a	ubiquitin protein ligase E3A	1085	0.24
chr16_20099366_20099741	0.03	Klhl24	kelch-like 24	1961	0.34
chr11_61956665_61956823	0.03	Specc1	sperm antigen with calponin homology and coiled-coil domains 1	19	0.97
chr1_153065207_153065385	0.03	Gm28960	predicted gene 28960	24211	0.16
chr19_40090171_40090346	0.03	Cyp2c50	cytochrome P450, family 2, subfamily c, polypeptide 50	523	0.79
chr3_95675100_95675253	0.03	Adamtsl4	ADAMTS-like 4	1975	0.19
chr4_105122583_105122738	0.03	Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit	12770	0.24
chr12_91752583_91752734	0.03	Ston2	stonin 2	6574	0.19
chr8_101351773_101352122	0.03	Gm22223	predicted gene, 22223	187761	0.03
chr6_90749634_90749799	0.03	Iqsec1	IQ motif and Sec7 domain 1	7834	0.18
chr15_97016628_97016815	0.03	Slc38a4	solute carrier family 38, member 4	3230	0.35
chr5_34761188_34761405	0.02	Htt	huntingtin	444	0.79
chr10_93454727_93454893	0.02	Lta4h	leukotriene A4 hydrolase	1359	0.37
chr13_95845056_95845225	0.02	Iqgap2	IQ motif containing GTPase activating protein 2	46617	0.13
chr3_90466862_90467019	0.02	Npr1	natriuretic peptide receptor 1	1074	0.28
chr17_32637044_32637195	0.02	Cyp4f37	cytochrome P450, family 4, subfamily f, polypeptide 37	2417	0.17
chr4_3937763_3937914	0.02	Plag1	pleiomorphic adenoma gene 1	544	0.59
chr17_24139636_24139851	0.02	Pdpk1	3-phosphoinositide dependent protein kinase 1	1064	0.31
chr4_15092272_15092451	0.02	Necab1	N-terminal EF-hand calcium binding protein 1	56600	0.12
chr4_65917251_65917420	0.02	Trim32	tripartite motif-containing 32	312086	0.01
chr6_138140741_138140961	0.02	Mgst1	microsomal glutathione S-transferase 1	252	0.95
chr17_5178904_5179070	0.02	Gm15599	predicted gene 15599	66877	0.12
chr10_128773852_128774003	0.02	Rpsa-ps2	ribosomal protein SA, pseudogene 2	3323	0.1
chr5_36740721_36740872	0.02	Gm43701	predicted gene 43701	7822	0.13
chr15_96284427_96284951	0.02	2610037D02Rik	RIKEN cDNA 2610037D02 gene	194	0.94
chr13_60175154_60175557	0.02	Gm48488	predicted gene, 48488	1327	0.33
chr8_26998828_26999051	0.02	Gm45370	predicted gene 45370	2689	0.14
chr17_47694436_47694638	0.02	Gm21981	predicted gene 21981	82	0.62
chr12_118337129_118337535	0.02	Sp4	trans-acting transcription factor 4	35892	0.2
chr9_43742856_43743217	0.02	Nectin1	nectin cell adhesion molecule 1	948	0.41
chr2_10098747_10098908	0.02	Kin	Kin17 DNA and RNA binding protein	8530	0.11
chr11_107376639_107376790	0.02	Gm11712	predicted gene 11712	10269	0.13
chr9_77744627_77744823	0.02	Gclc	glutamate-cysteine ligase, catalytic subunit	9810	0.13
chr3_146612054_146612933	0.02	Uox	urate oxidase	2508	0.19
chr4_43561781_43561932	0.02	Tln1	talin 1	301	0.56
chrX_166509851_166510002	0.02	Tceanc	transcription elongation factor A (SII) N-terminal and central domain containing	552	0.71
chr7_127769507_127769666	0.02	Orai3	ORAI calcium release-activated calcium modulator 3	229	0.82
chr3_151884312_151884485	0.02	Gm43617	predicted gene 43617	2905	0.23
chr13_38959459_38959624	0.02	Slc35b3	solute carrier family 35, member B3	939	0.42
chr8_107151582_107151800	0.02	Cyb5b	cytochrome b5 type B	1051	0.46
chr7_122970929_122971159	0.02	Rbbp6	retinoblastoma binding protein 6, ubiquitin ligase	126	0.92
chr8_26131886_26132040	0.02	Gm45251	predicted gene 45251	679	0.52
chr12_69127321_69127487	0.02	Gm31447	predicted gene, 31447	2432	0.12
chr1_58587381_58587553	0.02	Ndufb3	NADH:ubiquinone oxidoreductase subunit B3	1083	0.31
chr8_68008523_68008836	0.02	Gm22018	predicted gene, 22018	1661	0.43
chr18_12251815_12252003	0.02	Npc1	NPC intracellular cholesterol transporter 1	15509	0.14
chr10_96107868_96108070	0.02	Gm49817	predicted gene, 49817	11964	0.16
chr11_98836582_98836875	0.02	Rapgefl1	Rap guanine nucleotide exchange factor (GEF)-like 1	57	0.95
chr16_56528453_56528608	0.02	Abi3bp	ABI gene family, member 3 (NESH) binding protein	50630	0.16
chr2_80268198_80268374	0.02	Prdx6b	peroxiredoxin 6B	24186	0.2
chr11_85170747_85170928	0.02	1700125H20Rik	RIKEN cDNA 1700125H20 gene	259	0.89
chr7_105651071_105651233	0.02	Dnhd1	dynein heavy chain domain 1	325	0.75
chr11_72343979_72344154	0.02	Tekt1	tektin 1	17230	0.11
chr9_70889261_70889499	0.02	Gm3436	predicted pseudogene 3436	36804	0.14
chr3_115619931_115620082	0.02	S1pr1	sphingosine-1-phosphate receptor 1	95066	0.07
chr2_174532818_174532987	0.02	Gm14385	predicted gene 14385	47326	0.1
chr7_99827785_99828169	0.02	Neu3	neuraminidase 3	440	0.74
chr10_13007954_13008179	0.02	Sf3b5	splicing factor 3b, subunit 5	2723	0.26
chr2_35692024_35692382	0.02	Dab2ip	disabled 2 interacting protein	130	0.97
chr14_27337841_27338102	0.02	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	1905	0.38
chr8_127335297_127335467	0.02	Pard3	par-3 family cell polarity regulator	21033	0.28
chr3_142348416_142348578	0.02	Pdlim5	PDZ and LIM domain 5	43311	0.17
chr6_22363116_22363267	0.02	Fam3c	family with sequence similarity 3, member C	6948	0.28
chr11_48815924_48816180	0.02	Trim41	tripartite motif-containing 41	179	0.88
chr6_72787755_72787940	0.02	Tcf7l1	transcription factor 7 like 1 (T cell specific, HMG box)	751	0.63
chr1_182409523_182409985	0.02	Trp53bp2	transformation related protein 53 binding protein 2	582	0.49
chr9_103349628_103349779	0.02	Topbp1	topoisomerase (DNA) II binding protein 1	3475	0.19
chr4_131888523_131888751	0.02	Srsf4	serine and arginine-rich splicing factor 4	3429	0.13
chr4_134767914_134768168	0.02	Ldlrap1	low density lipoprotein receptor adaptor protein 1	17	0.98
chr1_31018387_31018720	0.02	4931428L18Rik	RIKEN cDNA 4931428L18 gene	18649	0.14
chr3_82857448_82857713	0.02	Rbm46	RNA binding motif protein 46	9067	0.17
chr9_22686906_22687072	0.02	Bbs9	Bardet-Biedl syndrome 9 (human)	8239	0.18
chr2_60046169_60046353	0.02	Gm13572	predicted gene 13572	9120	0.18
chr2_19919291_19919460	0.02	Etl4	enhancer trap locus 4	9595	0.17
chr2_80561396_80561547	0.02	Gm24461	predicted gene, 24461	2786	0.18
chr12_83618299_83618462	0.02	Gm6722	predicted gene 6722	2689	0.19
chr8_121583597_121583942	0.02	Gm17786	predicted gene, 17786	2004	0.19
chr13_23808562_23808721	0.02	Slc17a2	solute carrier family 17 (sodium phosphate), member 2	1593	0.16
chr19_44363419_44363596	0.02	Scd4	stearoyl-coenzyme A desaturase 4	30415	0.1
chr11_116099131_116099411	0.02	Trim47	tripartite motif-containing 47	7812	0.1
chr8_93328194_93328378	0.02	Ces1g	carboxylesterase 1G	9022	0.15
chr19_59939631_59939782	0.02	Rab11fip2	RAB11 family interacting protein 2 (class I)	3294	0.24
chr11_106802839_106802992	0.02	Cep95	centrosomal protein 95	9411	0.09
chr18_10913556_10913835	0.02	Gm7575	predicted gene 7575	15189	0.2
chr10_37261190_37261352	0.02	4930543K20Rik	RIKEN cDNA 4930543K20 gene	2477	0.38
chr6_143219492_143219655	0.02	1700126G02Rik	RIKEN cDNA 1700126G02 gene	1875	0.33
chr2_3672979_3673130	0.02	Gm13183	predicted gene 13183	7536	0.17
chr16_78969415_78969589	0.02	Gm15692	predicted gene 15692	5406	0.27
chr9_30427149_30427538	0.02	Snx19	sorting nexin 19	235	0.64
chr1_135787910_135788065	0.02	Tnni1	troponin I, skeletal, slow 1	4922	0.16
chr8_61574352_61574983	0.01	Palld	palladin, cytoskeletal associated protein	16472	0.25
chr19_3568557_3568708	0.01	Ppp6r3	protein phosphatase 6, regulatory subunit 3	7064	0.16
chr16_30945152_30945303	0.01	Gm46565	predicted gene, 46565	9598	0.17
chr2_121441237_121441474	0.01	Ell3	elongation factor RNA polymerase II-like 3	204	0.84
chr10_127745122_127745273	0.01	Zbtb39	zinc finger and BTB domain containing 39	5659	0.09
chr15_84674989_84675329	0.01	Prr5	proline rich 5 (renal)	5539	0.21
chr1_91095443_91095660	0.01	Lrrfip1	leucine rich repeat (in FLII) interacting protein 1	15663	0.18
chr2_103204688_103204993	0.01	Gm13869	predicted gene 13869	5517	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc4

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0046271	coumarin metabolic process(GO:0009804) phenylpropanoid catabolic process(GO:0046271)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0102007	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)

Results for Nfatc4

Z-value: 0.34

Motif logo

Transcription factors associated with Nfatc4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Nfatc4 motif across conditions

Conditions sorted by the z-value of the Nfatc4 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in molecular function category: