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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Nfatc4

Z-value: 0.34

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Transcription factors associated with Nfatc4

Gene Symbol	Gene ID	Gene Info
Nfatc4 Ensembl NCBI MGI UniProt	ENSMUSG00000023411.5	Nfatc4

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Nfatc4	chr14_55838433_55838623	8259	0.090845	0.78	6.6e-02	Click!
Nfatc4	chr14_55822593_55822771	462	0.651782	-0.46	3.6e-01	Click!
Nfatc4	chr14_55822818_55822969	251	0.833439	0.24	6.5e-01	Click!
Nfatc4	chr14_55829023_55829187	364	0.740165	-0.11	8.3e-01	Click!

Activity of the Nfatc4 motif across conditions

Conditions sorted by the z-value of the Nfatc4 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_93624235_93624413	0.10	Gm15622	predicted gene 15622	1058	0.48
chr3_83006212_83006467	0.09	Fgg	fibrinogen gamma chain	1385	0.32
chr6_118478658_118478809	0.09	Zfp9	zinc finger protein 9	587	0.69
chr4_97008802_97008953	0.07	Gm27521	predicted gene, 27521	91857	0.09
chr7_80559132_80559287	0.07	Blm	Bloom syndrome, RecQ like helicase	24090	0.13
chr5_145863264_145863516	0.07	Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	13301	0.16
chr3_18463182_18463725	0.07	Gm30667	predicted gene, 30667	2199	0.33
chr18_64334411_64334587	0.07	St8sia3os	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand	793	0.6
chr12_8506611_8506851	0.07	5033421B08Rik	RIKEN cDNA 5033421B08 gene	4470	0.17
chr5_128522783_128522934	0.07	Gm42499	predicted gene 42499	2637	0.23
chr1_121350895_121351046	0.06	2210011K15Rik	RIKEN cDNA 2210011K15 gene	8930	0.16
chr1_72173165_72173339	0.06	Mreg	melanoregulin	39055	0.11
chr2_67974374_67974909	0.06	Gm37964	predicted gene, 37964	76045	0.1
chr11_54587035_54587213	0.06	Rapgef6	Rap guanine nucleotide exchange factor (GEF) 6	9022	0.22
chr1_43827020_43827171	0.06	Uxs1	UDP-glucuronate decarboxylase 1	79	0.97
chr3_5235852_5236031	0.05	Zfhx4	zinc finger homeodomain 4	5731	0.22
chr10_14705733_14705924	0.05	Nmbr	neuromedin B receptor	201	0.57
chr9_65308324_65308479	0.05	Clpx	caseinolytic mitochondrial matrix peptidase chaperone subunit	1751	0.2
chr6_52577798_52578135	0.05	Gm44445	predicted gene, 44445	17414	0.13
chr1_162549290_162549454	0.05	Eef1aknmt	EEF1A lysine and N-terminal methyltransferase	821	0.61
chr6_27671661_27671812	0.05	Gm26310	predicted gene, 26310	3649	0.38
chr16_23102640_23102802	0.05	Eif4a2	eukaryotic translation initiation factor 4A2	4723	0.07
chr9_62335758_62335958	0.05	Anp32a	acidic (leucine-rich) nuclear phosphoprotein 32 family, member A	5435	0.21
chr18_34374027_34374186	0.05	Reep5	receptor accessory protein 5	36	0.97
chr6_123539742_123540032	0.05	Gm22722	predicted gene, 22722	145	0.94
chr4_53198055_53198206	0.05	4930412L05Rik	RIKEN cDNA 4930412L05 gene	19431	0.17
chr4_97838379_97838530	0.05	Nfia	nuclear factor I/A	41665	0.17
chr2_177839201_177839672	0.05	Gm14325	predicted gene 14325	882	0.56
chr6_123424383_123424683	0.05	Vmn2r-ps31	vomeronasal 2, receptor, pseudogene 31	91	0.59
chr4_148160291_148160511	0.05	Fbxo44	F-box protein 44	81	0.68
chr2_177498894_177499115	0.04	Gm14403	predicted gene 14403	689	0.65
chr5_25227061_25227222	0.04	E130116L18Rik	RIKEN cDNA E130116L18 gene	3988	0.18
chr9_70890743_70891063	0.04	Gm3436	predicted pseudogene 3436	38327	0.14
chr2_155091972_155092151	0.04	Gm45609	predicted gene 45609	3683	0.17
chr13_23298661_23298830	0.04	Gm11333	predicted gene 11333	696	0.46
chr11_83913932_83914083	0.04	Ddx52	DEAD (Asp-Glu-Ala-Asp) box polypeptide 52	28055	0.14
chr11_87991621_87991895	0.04	Dynll2	dynein light chain LC8-type 2	4225	0.16
chr6_38144181_38144332	0.04	D630045J12Rik	RIKEN cDNA D630045J12 gene	3118	0.22
chr12_71042601_71042779	0.04	Arid4a	AT rich interactive domain 4A (RBP1-like)	5651	0.18
chr5_37952218_37952372	0.04	Gm40289	predicted gene, 40289	31398	0.16
chr19_55266477_55266642	0.04	Acsl5	acyl-CoA synthetase long-chain family member 5	6311	0.18
chr12_26444164_26444328	0.04	Gm47799	predicted gene, 47799	7427	0.14
chr6_31253045_31253249	0.04	2210408F21Rik	RIKEN cDNA 2210408F21 gene	24701	0.14
chr9_76273523_76273711	0.04	Gm27234	predicted gene 27234	45960	0.14
chr19_4786093_4786325	0.04	Rbm4	RNA binding motif protein 4	7642	0.08
chr3_79849200_79849377	0.04	Tmem144	transmembrane protein 144	3480	0.21
chr1_195014918_195015345	0.04	9630010A21Rik	RIKEN cDNA 9630010A21 gene	1385	0.22
chr14_62883124_62883275	0.04	n-R5s47	nuclear encoded rRNA 5S 47	13485	0.13
chr18_35278082_35278245	0.04	Gm50146	predicted gene, 50146	14134	0.16
chr9_95568845_95568996	0.04	Paqr9	progestin and adipoQ receptor family member IX	9263	0.13
chr4_33245946_33246487	0.04	Pnrc1	proline-rich nuclear receptor coactivator 1	1359	0.39
chr7_136820396_136820744	0.04	Gm9347	predicted gene 9347	9661	0.26
chr2_166972459_166972619	0.04	Stau1	staufen double-stranded RNA binding protein 1	4232	0.15
chr15_57468422_57468573	0.04	Slc22a22	solute carrier family 22 (organic cation transporter), member 22	9128	0.21
chr1_172988114_172988265	0.04	Olfr16	olfactory receptor 16	31421	0.13
chr11_3144349_3144521	0.04	Sfi1	Sfi1 homolog, spindle assembly associated (yeast)	1921	0.21
chr17_81375771_81376164	0.04	Gm50044	predicted gene, 50044	5134	0.28
chr11_31785587_31785738	0.04	D630024D03Rik	RIKEN cDNA D630024D03 gene	38811	0.15
chr14_59442931_59443277	0.04	Cab39l	calcium binding protein 39-like	2123	0.24
chr8_59870347_59870498	0.04	4930470O06Rik	RIKEN cDNA 4930470O06 gene	44773	0.2
chr18_56756491_56756863	0.04	Gm15345	predicted gene 15345	13040	0.18
chr6_48677382_48677533	0.03	Gimap9	GTPase, IMAP family member 9	54	0.93
chr3_116934960_116935115	0.03	Gm42892	predicted gene 42892	9293	0.14
chr6_5256423_5256653	0.03	Pon3	paraoxonase 3	252	0.91
chr5_104374044_104374195	0.03	Mepe	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	48790	0.1
chr7_63887410_63887577	0.03	Gm27252	predicted gene 27252	9040	0.15
chr7_16591375_16591549	0.03	Gm29443	predicted gene 29443	22362	0.09
chr15_6237986_6238213	0.03	Dab2	disabled 2, mitogen-responsive phosphoprotein	61689	0.11
chr10_94199177_94199540	0.03	Ndufa12	NADH:ubiquinone oxidoreductase subunit A12	321	0.87
chr4_49407628_49408150	0.03	Acnat2	acyl-coenzyme A amino acid N-acyltransferase 2	262	0.88
chr4_135728255_135728588	0.03	Il22ra1	interleukin 22 receptor, alpha 1	249	0.89
chr1_67162712_67162908	0.03	Cps1	carbamoyl-phosphate synthetase 1	39784	0.16
chr13_81315073_81315331	0.03	Adgrv1	adhesion G protein-coupled receptor V1	27634	0.22
chr5_88693031_88693182	0.03	Grsf1	G-rich RNA sequence binding factor 1	16935	0.14
chr1_67190099_67190250	0.03	Gm15668	predicted gene 15668	59026	0.11
chr11_86347511_86347911	0.03	Med13	mediator complex subunit 13	9891	0.21
chr9_86355672_86355847	0.03	Gm16202	predicted gene 16202	39075	0.18
chr4_95586493_95586698	0.03	Fggy	FGGY carbohydrate kinase domain containing	320	0.9
chr7_114066134_114066326	0.03	Gm45615	predicted gene 45615	20668	0.22
chr2_128377797_128377975	0.03	Morrbid	myeloid RNA regulator of BCL2L11 induced cell death	25079	0.18
chr6_128523521_128524414	0.03	Pzp	PZP, alpha-2-macroglobulin like	2736	0.13
chr4_53011559_53011710	0.03	Nipsnap3b	nipsnap homolog 3B	246	0.9
chr13_105088917_105089088	0.03	Nt5el	5' nucleotidase, ecto-like	6880	0.25
chr10_44002186_44002407	0.03	Gm10812	predicted gene 10812	1858	0.29
chr18_63689863_63690014	0.03	Txnl1	thioredoxin-like 1	2384	0.27
chr14_109874316_109874480	0.03	Gm25901	predicted gene, 25901	8785	0.3
chr5_36557509_36557955	0.03	Tbc1d14	TBC1 domain family, member 14	6324	0.17
chr2_27626035_27626261	0.03	Rxra	retinoid X receptor alpha	50292	0.12
chr18_16797289_16797482	0.03	Cdh2	cadherin 2	11077	0.2
chr11_4822321_4822472	0.03	Nf2	neurofibromin 2	2000	0.29
chr10_128918530_128918929	0.03	Rdh5	retinol dehydrogenase 5	24	0.94
chr19_12598432_12598680	0.03	Gm4952	predicted gene 4952	1418	0.23
chr10_21158162_21158313	0.03	Myb	myeloblastosis oncogene	1592	0.3
chr19_55260197_55260377	0.03	Acsl5	acyl-CoA synthetase long-chain family member 5	6918	0.18
chr17_27805546_27805714	0.03	Ilrun	inflammation and lipid regulator with UBA-like and NBR1-like domains	14822	0.11
chr14_57998520_57998724	0.03	Micu2	mitochondrial calcium uptake 2	576	0.5
chr18_12761990_12762141	0.03	Osbpl1a	oxysterol binding protein-like 1A	5072	0.16
chr12_111819707_111819858	0.03	Zfyve21	zinc finger, FYVE domain containing 21	3526	0.14
chr10_54046292_54046454	0.03	Gm47917	predicted gene, 47917	17438	0.19
chr6_13280975_13281131	0.03	AC121573.1	predicted 725	17308	0.23
chr6_14897753_14897997	0.03	Foxp2	forkhead box P2	3474	0.38
chr4_147426052_147426209	0.03	Gm13161	predicted gene 13161	17341	0.12
chr7_59230441_59230601	0.03	Ube3a	ubiquitin protein ligase E3A	1085	0.24
chr16_20099366_20099741	0.03	Klhl24	kelch-like 24	1961	0.34
chr11_61956665_61956823	0.03	Specc1	sperm antigen with calponin homology and coiled-coil domains 1	19	0.97
chr1_153065207_153065385	0.03	Gm28960	predicted gene 28960	24211	0.16
chr19_40090171_40090346	0.03	Cyp2c50	cytochrome P450, family 2, subfamily c, polypeptide 50	523	0.79
chr3_95675100_95675253	0.03	Adamtsl4	ADAMTS-like 4	1975	0.19
chr4_105122583_105122738	0.03	Prkaa2	protein kinase, AMP-activated, alpha 2 catalytic subunit	12770	0.24
chr12_91752583_91752734	0.03	Ston2	stonin 2	6574	0.19
chr8_101351773_101352122	0.03	Gm22223	predicted gene, 22223	187761	0.03
chr6_90749634_90749799	0.03	Iqsec1	IQ motif and Sec7 domain 1	7834	0.18
chr15_97016628_97016815	0.03	Slc38a4	solute carrier family 38, member 4	3230	0.35
chr5_34761188_34761405	0.02	Htt	huntingtin	444	0.79
chr10_93454727_93454893	0.02	Lta4h	leukotriene A4 hydrolase	1359	0.37
chr13_95845056_95845225	0.02	Iqgap2	IQ motif containing GTPase activating protein 2	46617	0.13
chr3_90466862_90467019	0.02	Npr1	natriuretic peptide receptor 1	1074	0.28
chr17_32637044_32637195	0.02	Cyp4f37	cytochrome P450, family 4, subfamily f, polypeptide 37	2417	0.17
chr4_3937763_3937914	0.02	Plag1	pleiomorphic adenoma gene 1	544	0.59
chr17_24139636_24139851	0.02	Pdpk1	3-phosphoinositide dependent protein kinase 1	1064	0.31
chr4_15092272_15092451	0.02	Necab1	N-terminal EF-hand calcium binding protein 1	56600	0.12
chr4_65917251_65917420	0.02	Trim32	tripartite motif-containing 32	312086	0.01
chr6_138140741_138140961	0.02	Mgst1	microsomal glutathione S-transferase 1	252	0.95
chr17_5178904_5179070	0.02	Gm15599	predicted gene 15599	66877	0.12
chr10_128773852_128774003	0.02	Rpsa-ps2	ribosomal protein SA, pseudogene 2	3323	0.1
chr5_36740721_36740872	0.02	Gm43701	predicted gene 43701	7822	0.13
chr15_96284427_96284951	0.02	2610037D02Rik	RIKEN cDNA 2610037D02 gene	194	0.94
chr13_60175154_60175557	0.02	Gm48488	predicted gene, 48488	1327	0.33
chr8_26998828_26999051	0.02	Gm45370	predicted gene 45370	2689	0.14
chr17_47694436_47694638	0.02	Gm21981	predicted gene 21981	82	0.62
chr12_118337129_118337535	0.02	Sp4	trans-acting transcription factor 4	35892	0.2
chr9_43742856_43743217	0.02	Nectin1	nectin cell adhesion molecule 1	948	0.41
chr2_10098747_10098908	0.02	Kin	Kin17 DNA and RNA binding protein	8530	0.11
chr11_107376639_107376790	0.02	Gm11712	predicted gene 11712	10269	0.13
chr9_77744627_77744823	0.02	Gclc	glutamate-cysteine ligase, catalytic subunit	9810	0.13
chr3_146612054_146612933	0.02	Uox	urate oxidase	2508	0.19
chr4_43561781_43561932	0.02	Tln1	talin 1	301	0.56
chrX_166509851_166510002	0.02	Tceanc	transcription elongation factor A (SII) N-terminal and central domain containing	552	0.71
chr7_127769507_127769666	0.02	Orai3	ORAI calcium release-activated calcium modulator 3	229	0.82
chr3_151884312_151884485	0.02	Gm43617	predicted gene 43617	2905	0.23
chr13_38959459_38959624	0.02	Slc35b3	solute carrier family 35, member B3	939	0.42
chr8_107151582_107151800	0.02	Cyb5b	cytochrome b5 type B	1051	0.46
chr7_122970929_122971159	0.02	Rbbp6	retinoblastoma binding protein 6, ubiquitin ligase	126	0.92
chr8_26131886_26132040	0.02	Gm45251	predicted gene 45251	679	0.52
chr12_69127321_69127487	0.02	Gm31447	predicted gene, 31447	2432	0.12
chr1_58587381_58587553	0.02	Ndufb3	NADH:ubiquinone oxidoreductase subunit B3	1083	0.31
chr8_68008523_68008836	0.02	Gm22018	predicted gene, 22018	1661	0.43
chr18_12251815_12252003	0.02	Npc1	NPC intracellular cholesterol transporter 1	15509	0.14
chr10_96107868_96108070	0.02	Gm49817	predicted gene, 49817	11964	0.16
chr11_98836582_98836875	0.02	Rapgefl1	Rap guanine nucleotide exchange factor (GEF)-like 1	57	0.95
chr16_56528453_56528608	0.02	Abi3bp	ABI gene family, member 3 (NESH) binding protein	50630	0.16
chr2_80268198_80268374	0.02	Prdx6b	peroxiredoxin 6B	24186	0.2
chr11_85170747_85170928	0.02	1700125H20Rik	RIKEN cDNA 1700125H20 gene	259	0.89
chr7_105651071_105651233	0.02	Dnhd1	dynein heavy chain domain 1	325	0.75
chr11_72343979_72344154	0.02	Tekt1	tektin 1	17230	0.11
chr9_70889261_70889499	0.02	Gm3436	predicted pseudogene 3436	36804	0.14
chr3_115619931_115620082	0.02	S1pr1	sphingosine-1-phosphate receptor 1	95066	0.07
chr2_174532818_174532987	0.02	Gm14385	predicted gene 14385	47326	0.1
chr7_99827785_99828169	0.02	Neu3	neuraminidase 3	440	0.74
chr10_13007954_13008179	0.02	Sf3b5	splicing factor 3b, subunit 5	2723	0.26
chr2_35692024_35692382	0.02	Dab2ip	disabled 2 interacting protein	130	0.97
chr14_27337841_27338102	0.02	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	1905	0.38
chr8_127335297_127335467	0.02	Pard3	par-3 family cell polarity regulator	21033	0.28
chr3_142348416_142348578	0.02	Pdlim5	PDZ and LIM domain 5	43311	0.17
chr6_22363116_22363267	0.02	Fam3c	family with sequence similarity 3, member C	6948	0.28
chr11_48815924_48816180	0.02	Trim41	tripartite motif-containing 41	179	0.88
chr6_72787755_72787940	0.02	Tcf7l1	transcription factor 7 like 1 (T cell specific, HMG box)	751	0.63
chr1_182409523_182409985	0.02	Trp53bp2	transformation related protein 53 binding protein 2	582	0.49
chr9_103349628_103349779	0.02	Topbp1	topoisomerase (DNA) II binding protein 1	3475	0.19
chr4_131888523_131888751	0.02	Srsf4	serine and arginine-rich splicing factor 4	3429	0.13
chr4_134767914_134768168	0.02	Ldlrap1	low density lipoprotein receptor adaptor protein 1	17	0.98
chr1_31018387_31018720	0.02	4931428L18Rik	RIKEN cDNA 4931428L18 gene	18649	0.14
chr3_82857448_82857713	0.02	Rbm46	RNA binding motif protein 46	9067	0.17
chr9_22686906_22687072	0.02	Bbs9	Bardet-Biedl syndrome 9 (human)	8239	0.18
chr2_60046169_60046353	0.02	Gm13572	predicted gene 13572	9120	0.18
chr2_19919291_19919460	0.02	Etl4	enhancer trap locus 4	9595	0.17
chr2_80561396_80561547	0.02	Gm24461	predicted gene, 24461	2786	0.18
chr12_83618299_83618462	0.02	Gm6722	predicted gene 6722	2689	0.19
chr8_121583597_121583942	0.02	Gm17786	predicted gene, 17786	2004	0.19
chr13_23808562_23808721	0.02	Slc17a2	solute carrier family 17 (sodium phosphate), member 2	1593	0.16
chr19_44363419_44363596	0.02	Scd4	stearoyl-coenzyme A desaturase 4	30415	0.1
chr11_116099131_116099411	0.02	Trim47	tripartite motif-containing 47	7812	0.1
chr8_93328194_93328378	0.02	Ces1g	carboxylesterase 1G	9022	0.15
chr19_59939631_59939782	0.02	Rab11fip2	RAB11 family interacting protein 2 (class I)	3294	0.24
chr11_106802839_106802992	0.02	Cep95	centrosomal protein 95	9411	0.09
chr18_10913556_10913835	0.02	Gm7575	predicted gene 7575	15189	0.2
chr10_37261190_37261352	0.02	4930543K20Rik	RIKEN cDNA 4930543K20 gene	2477	0.38
chr6_143219492_143219655	0.02	1700126G02Rik	RIKEN cDNA 1700126G02 gene	1875	0.33
chr2_3672979_3673130	0.02	Gm13183	predicted gene 13183	7536	0.17
chr16_78969415_78969589	0.02	Gm15692	predicted gene 15692	5406	0.27
chr9_30427149_30427538	0.02	Snx19	sorting nexin 19	235	0.64
chr1_135787910_135788065	0.02	Tnni1	troponin I, skeletal, slow 1	4922	0.16
chr8_61574352_61574983	0.01	Palld	palladin, cytoskeletal associated protein	16472	0.25
chr19_3568557_3568708	0.01	Ppp6r3	protein phosphatase 6, regulatory subunit 3	7064	0.16
chr16_30945152_30945303	0.01	Gm46565	predicted gene, 46565	9598	0.17
chr2_121441237_121441474	0.01	Ell3	elongation factor RNA polymerase II-like 3	204	0.84
chr10_127745122_127745273	0.01	Zbtb39	zinc finger and BTB domain containing 39	5659	0.09
chr15_84674989_84675329	0.01	Prr5	proline rich 5 (renal)	5539	0.21
chr1_91095443_91095660	0.01	Lrrfip1	leucine rich repeat (in FLII) interacting protein 1	15663	0.18
chr2_103204688_103204993	0.01	Gm13869	predicted gene 13869	5517	0.19

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfatc4

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0046271	coumarin metabolic process(GO:0009804) phenylpropanoid catabolic process(GO:0046271)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.0	GO:0102007	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.0	GO:0004946	bombesin receptor activity(GO:0004946)