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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Nfe2l1_Mafg

Z-value: 0.98

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Transcription factors associated with Nfe2l1_Mafg

Gene Symbol	Gene ID	Gene Info
Nfe2l1 Ensembl NCBI MGI UniProt	ENSMUSG00000038615.11	nuclear factor, erythroid derived 2,-like 1
Mafg Ensembl NCBI MGI UniProt	ENSMUSG00000051510.7	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)
Mafg Ensembl NCBI MGI UniProt	ENSMUSG00000053906.4	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein G (avian)

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr11_120632589_120632750	Mafg	887	0.260451	-0.97	1.1e-03	Click!
chr11_120629221_120629376	Mafg	850	0.270332	-0.97	1.2e-03	Click!
chr11_120629382_120629533	Mafg	691	0.345206	-0.95	4.3e-03	Click!
chr11_120633556_120633720	Mafg	38	0.910356	-0.95	4.4e-03	Click!
chr11_120630495_120630798	Mafg	10	0.914170	-0.87	2.4e-02	Click!
chr11_96824156_96824315	Nfe2l1	108	0.933526	-0.98	3.7e-04	Click!
chr11_96822735_96822898	Nfe2l1	91	0.939857	-0.94	5.7e-03	Click!
chr11_96826613_96826784	Nfe2l1	1021	0.354776	-0.92	1.0e-02	Click!
chr11_96826021_96826172	Nfe2l1	1544	0.232334	0.89	1.7e-02	Click!
chr11_96829364_96829648	Nfe2l1	4	0.954420	-0.87	2.3e-02	Click!

Activity of the Nfe2l1_Mafg motif across conditions

Conditions sorted by the z-value of the Nfe2l1_Mafg motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_75873468_75873620	0.49	Gm47744	predicted gene, 47744	1887	0.18
chr3_158062237_158062399	0.43	Lrrc40	leucine rich repeat containing 40	40	0.97
chr19_40153747_40153898	0.36	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	33464	0.13
chr12_104000672_104000833	0.33	Gm28577	predicted gene 28577	4173	0.12
chr11_7816093_7816451	0.31	Gm27393	predicted gene, 27393	70233	0.13
chr6_149189382_149189536	0.31	Amn1	antagonist of mitotic exit network 1	747	0.6
chr3_138282244_138282429	0.30	Adh1	alcohol dehydrogenase 1 (class I)	4685	0.14
chr12_104082595_104082890	0.29	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	2093	0.18
chr13_82200174_82200343	0.29	Gm48155	predicted gene, 48155	110501	0.07
chr13_4270161_4270342	0.28	Akr1c12	aldo-keto reductase family 1, member C12	9182	0.15
chr4_141955631_141955810	0.28	Fhad1	forkhead-associated (FHA) phosphopeptide binding domain 1	1526	0.3
chr6_22340862_22341016	0.28	Fam3c	family with sequence similarity 3, member C	2974	0.34
chr19_40158328_40158479	0.27	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	28883	0.13
chr1_162892140_162892544	0.27	Fmo2	flavin containing monooxygenase 2	5827	0.19
chr2_58773911_58774203	0.25	Upp2	uridine phosphorylase 2	8732	0.21
chr18_81319673_81319824	0.25	Gm30192	predicted gene, 30192	55040	0.14
chr2_134491985_134492278	0.25	Hao1	hydroxyacid oxidase 1, liver	62176	0.15
chr5_49060180_49060366	0.24	Gm43047	predicted gene 43047	9730	0.1
chr7_63923519_63923771	0.24	Klf13	Kruppel-like factor 13	1225	0.37
chr4_104868512_104868743	0.24	C8a	complement component 8, alpha polypeptide	7756	0.2
chr12_104084479_104084838	0.24	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	4009	0.12
chr4_76964290_76964441	0.24	Gm23159	predicted gene, 23159	5867	0.27
chr13_45623869_45624201	0.24	Gmpr	guanosine monophosphate reductase	77882	0.1
chr8_9501766_9501947	0.23	4930435N07Rik	RIKEN cDNA 4930435N07 gene	42764	0.13
chr6_24049175_24049330	0.23	Slc13a1	solute carrier family 13 (sodium/sulfate symporters), member 1	59319	0.12
chr8_93164567_93164980	0.23	Ces1d	carboxylesterase 1D	5202	0.15
chr11_90321650_90321810	0.23	Hlf	hepatic leukemia factor	60205	0.12
chr5_43310353_43310569	0.23	Gm43020	predicted gene 43020	44798	0.11
chr6_135782336_135782495	0.22	Gm22892	predicted gene, 22892	41418	0.15
chr8_40651238_40651389	0.22	Mtmr7	myotubularin related protein 7	16516	0.14
chr3_18138170_18138321	0.22	Gm23686	predicted gene, 23686	39380	0.16
chr2_147988721_147988917	0.22	9030622O22Rik	RIKEN cDNA 9030622O22 gene	12634	0.21
chr13_24377886_24378061	0.22	Cmah	cytidine monophospho-N-acetylneuraminic acid hydroxylase	1890	0.23
chr1_193926856_193927030	0.22	Gm21362	predicted gene, 21362	59934	0.16
chr6_24610042_24610446	0.22	Lmod2	leiomodin 2 (cardiac)	12482	0.14
chr19_40156899_40157166	0.22	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	30254	0.13
chr3_18111157_18111308	0.22	Gm23726	predicted gene, 23726	41906	0.14
chr19_56171122_56171273	0.21	Gm31912	predicted gene, 31912	64887	0.11
chr18_42796496_42796654	0.21	Ppp2r2b	protein phosphatase 2, regulatory subunit B, beta	102240	0.07
chr7_35748679_35748830	0.21	Dpy19l3	dpy-19-like 3 (C. elegans)	5601	0.2
chr8_36265736_36265923	0.21	Lonrf1	LON peptidase N-terminal domain and ring finger 1	16313	0.2
chr6_51657319_51657493	0.21	Gm22914	predicted gene, 22914	35774	0.17
chr7_132967481_132967632	0.21	Zranb1	zinc finger, RAN-binding domain containing 1	13303	0.14
chr17_10401671_10401822	0.21	A230009B12Rik	RIKEN cDNA A230009B12 gene	54470	0.13
chr11_16808519_16808674	0.21	Egfros	epidermal growth factor receptor, opposite strand	22106	0.19
chr6_137784539_137784690	0.21	Dera	deoxyribose-phosphate aldolase (putative)	3791	0.29
chr8_105095287_105095438	0.21	Ces3b	carboxylesterase 3B	6743	0.11
chr12_69758939_69759328	0.21	Mir681	microRNA 681	4811	0.14
chr10_87865511_87865999	0.20	Igf1os	insulin-like growth factor 1, opposite strand	2374	0.3
chr13_102050615_102050815	0.20	Gm38133	predicted gene, 38133	65320	0.13
chr15_59005379_59005677	0.20	4930544F09Rik	RIKEN cDNA 4930544F09 gene	21392	0.16
chr14_11132064_11132231	0.20	Fhit	fragile histidine triad gene	6556	0.25
chr3_95879412_95879563	0.20	Ciart	circadian associated repressor of transcription	1759	0.16
chr1_91464737_91464909	0.20	Gm28381	predicted gene 28381	5275	0.12
chr1_21264707_21265188	0.20	Gm28836	predicted gene 28836	6646	0.11
chr5_63837978_63838129	0.20	0610040J01Rik	RIKEN cDNA 0610040J01 gene	25533	0.17
chr18_11317026_11317247	0.19	Gata6	GATA binding protein 6	258089	0.02
chr12_57317079_57317230	0.19	Mipol1	mirror-image polydactyly 1	11071	0.22
chr4_54954362_54954516	0.19	Zfp462	zinc finger protein 462	6463	0.29
chr15_83202825_83203000	0.19	7530414M10Rik	RIKEN cDNA 7530414M10 gene	26467	0.1
chr12_57515437_57515691	0.19	Gm2568	predicted gene 2568	5060	0.18
chr7_25884401_25884651	0.19	Gm6434	predicted gene 6434	2137	0.18
chr5_100408563_100408720	0.19	Sec31a	Sec31 homolog A (S. cerevisiae)	971	0.48
chr17_64684263_64684445	0.19	Man2a1	mannosidase 2, alpha 1	29066	0.2
chr16_79086922_79087073	0.19	Tmprss15	transmembrane protease, serine 15	4095	0.35
chr16_93333790_93334136	0.19	1810053B23Rik	RIKEN cDNA 1810053B23 gene	19226	0.18
chr6_147954211_147954549	0.19	Far2	fatty acyl CoA reductase 2	92879	0.07
chr8_93191975_93192208	0.19	Gm45909	predicted gene 45909	733	0.57
chr6_90478594_90478745	0.18	Gm44421	predicted gene, 44421	203	0.89
chr9_122056710_122056883	0.18	Gm39465	predicted gene, 39465	5333	0.13
chr8_93192874_93193058	0.18	Gm45909	predicted gene 45909	1608	0.28
chr7_63899068_63899509	0.18	Gm27252	predicted gene 27252	1314	0.37
chr2_160797768_160797919	0.18	Plcg1	phospholipase C, gamma 1	37725	0.11
chr6_51578534_51578718	0.18	Snx10	sorting nexin 10	34060	0.16
chr6_38769722_38769895	0.18	Hipk2	homeodomain interacting protein kinase 2	26548	0.2
chr5_125529429_125529580	0.18	Tmem132b	transmembrane protein 132B	2270	0.26
chr8_77410509_77410680	0.18	Gm45407	predicted gene 45407	38078	0.15
chr3_51226339_51227024	0.18	Noct	nocturnin	2211	0.23
chr6_67441579_67441755	0.18	Gm44083	predicted gene, 44083	23616	0.11
chr7_99969637_99969788	0.18	Rnf169	ring finger protein 169	3978	0.16
chr7_98358819_98359055	0.18	Tsku	tsukushi, small leucine rich proteoglycan	1142	0.47
chr14_18304273_18304424	0.18	Ube2e1	ubiquitin-conjugating enzyme E2E 1	22943	0.14
chr19_40183641_40183792	0.18	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	3570	0.19
chr2_131452202_131452379	0.18	Gm14304	predicted gene 14304	2350	0.25
chr7_70499142_70499303	0.18	Gm7656	predicted gene 7656	8374	0.15
chr9_66697369_66697520	0.18	Car12	carbonic anhydrase 12	16242	0.19
chr5_33024447_33024632	0.18	Ywhah	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide	2748	0.21
chr2_5839502_5839908	0.18	Cdc123	cell division cycle 123	5146	0.16
chr13_96960473_96960682	0.18	Gm48597	predicted gene, 48597	9663	0.17
chr14_10751127_10751283	0.18	Fhitos	fragile histidine triad gene, opposite strand	12652	0.25
chr14_86444521_86444715	0.17	Gm32913	predicted gene, 32913	35519	0.14
chr14_118008711_118008863	0.17	Dct	dopachrome tautomerase	18748	0.19
chr2_31493649_31493953	0.17	Ass1	argininosuccinate synthetase 1	3971	0.22
chr3_142862185_142862381	0.17	Pkn2	protein kinase N2	6548	0.15
chr9_64357609_64357961	0.17	Dis3l	DIS3 like exosome 3'-5' exoribonuclease	16497	0.16
chr6_128432450_128432601	0.17	Fkbp4	FK506 binding protein 4	5128	0.08
chr15_3470533_3470724	0.17	Ghr	growth hormone receptor	1016	0.68
chr4_6919330_6919515	0.17	Tox	thymocyte selection-associated high mobility group box	71061	0.12
chr16_76330855_76331006	0.17	Nrip1	nuclear receptor interacting protein 1	7272	0.24
chr19_31881164_31881315	0.17	A1cf	APOBEC1 complementation factor	12458	0.22
chr2_31510334_31510882	0.17	Ass1	argininosuccinate synthetase 1	7882	0.18
chr15_3506426_3506577	0.17	Ghr	growth hormone receptor	34857	0.21
chr13_44285946_44286097	0.17	Gm29676	predicted gene, 29676	5572	0.22
chr3_133740354_133740509	0.17	Gm6135	prediticted gene 6135	51073	0.13
chr1_192812225_192812480	0.17	Gm38360	predicted gene, 38360	8775	0.14
chr18_36665669_36665887	0.17	Eif4ebp3	eukaryotic translation initiation factor 4E binding protein 3	1718	0.17
chr11_28695418_28695578	0.16	2810471M01Rik	RIKEN cDNA 2810471M01 gene	13934	0.17
chr3_97637473_97637939	0.16	Fmo5	flavin containing monooxygenase 5	8823	0.13
chr13_44250819_44251012	0.16	Gm29676	predicted gene, 29676	1755	0.34
chr19_14736673_14736829	0.16	Gm26026	predicted gene, 26026	18271	0.26
chr1_107939897_107940125	0.16	D830032E09Rik	RIKEN cDNA D830032E09 gene	3302	0.23
chr8_114151087_114151399	0.16	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	17601	0.25
chr3_52011173_52011324	0.16	Gm37465	predicted gene, 37465	7223	0.13
chr3_116915063_116915225	0.16	Frrs1	ferric-chelate reductase 1	18434	0.13
chr16_42172601_42172764	0.16	Gm49737	predicted gene, 49737	12235	0.2
chr11_16851040_16851282	0.16	Egfros	epidermal growth factor receptor, opposite strand	20459	0.18
chr5_33459431_33459801	0.16	Gm43851	predicted gene 43851	22152	0.16
chr1_88132349_88132542	0.16	Ugt1a6a	UDP glucuronosyltransferase 1 family, polypeptide A6A	2364	0.1
chr8_114142907_114143190	0.16	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	9406	0.28
chr15_55043831_55044027	0.16	Taf2	TATA-box binding protein associated factor 2	2237	0.26
chr2_109488302_109488457	0.16	Gm13925	predicted gene 13925	11376	0.23
chr5_151042731_151042918	0.16	Gm8675	predicted gene 8675	33523	0.17
chr3_51198208_51198374	0.16	Noct	nocturnin	26156	0.14
chr9_72702491_72702671	0.16	Nedd4	neural precursor cell expressed, developmentally down-regulated 4	9142	0.1
chr3_97225695_97225846	0.16	Bcl9	B cell CLL/lymphoma 9	1561	0.36
chr11_6158649_6158802	0.16	Rps15a-ps6	ribosomal protein S15A, pseudogene 6	14311	0.13
chr10_89471287_89471467	0.16	Gas2l3	growth arrest-specific 2 like 3	27410	0.18
chr4_99028977_99029128	0.16	Angptl3	angiopoietin-like 3	1902	0.32
chr11_16818044_16818409	0.16	Egfros	epidermal growth factor receptor, opposite strand	12476	0.22
chr3_98738287_98738502	0.16	Hsd3b2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	13851	0.13
chr12_83685921_83686270	0.16	Psen1	presenilin 1	2057	0.23
chr15_85766228_85766381	0.16	Ppara	peroxisome proliferator activated receptor alpha	5910	0.16
chr10_14012990_14013158	0.16	Hivep2	human immunodeficiency virus type I enhancer binding protein 2	46050	0.14
chr1_161240339_161240617	0.16	Prdx6	peroxiredoxin 6	10076	0.16
chr9_106240931_106241179	0.15	Alas1	aminolevulinic acid synthase 1	1022	0.36
chr6_21827909_21828060	0.15	Tspan12	tetraspanin 12	23844	0.17
chr14_89610572_89610930	0.15	Gm25415	predicted gene, 25415	96054	0.09
chr19_17311642_17311793	0.15	Gcnt1	glucosaminyl (N-acetyl) transferase 1, core 2	23719	0.17
chr11_5499044_5499213	0.15	Gm11963	predicted gene 11963	288	0.86
chr1_67230512_67230663	0.15	Gm15668	predicted gene 15668	18613	0.21
chr17_45924651_45924805	0.15	Gm49805	predicted gene, 49805	37131	0.12
chr7_119961192_119961374	0.15	Dnah3	dynein, axonemal, heavy chain 3	6559	0.16
chr10_87532342_87532676	0.15	Pah	phenylalanine hydroxylase	10482	0.2
chr8_29133062_29133289	0.15	Svet1	subventricular expressed transcript 1	20399	0.19
chr3_29835547_29835722	0.15	Mannr	Mecom adjacent non-protein coding RNA	55380	0.12
chr18_75498893_75499229	0.15	Gm10532	predicted gene 10532	15584	0.25
chr9_106271509_106271729	0.15	Poc1a	POC1 centriolar protein A	9442	0.11
chr14_118948462_118948868	0.15	Dnajc3	DnaJ heat shock protein family (Hsp40) member C3	10689	0.16
chr10_127407277_127407450	0.15	Gm23819	predicted gene, 23819	2971	0.15
chr7_72323573_72323742	0.15	Mctp2	multiple C2 domains, transmembrane 2	17049	0.28
chrX_166678508_166678678	0.15	Gm1720	predicted gene 1720	16568	0.21
chr6_24602762_24602931	0.15	Lmod2	leiomodin 2 (cardiac)	5084	0.17
chr13_14180280_14180431	0.15	Arid4b	AT rich interactive domain 4B (RBP1-like)	2372	0.25
chr10_93075982_93076133	0.15	Cfap54	cilia and flagella associated protein 54	5539	0.22
chr10_117437437_117437791	0.15	Gm9002	predicted gene 9002	7996	0.14
chr11_75737051_75737202	0.15	Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	3978	0.19
chr1_21259661_21259812	0.15	Gsta3	glutathione S-transferase, alpha 3	6215	0.11
chr9_48599126_48599309	0.14	Nnmt	nicotinamide N-methyltransferase	1768	0.43
chr10_87536307_87536462	0.14	Pah	phenylalanine hydroxylase	10289	0.2
chr10_67100073_67100416	0.14	Reep3	receptor accessory protein 3	3299	0.24
chr1_192126218_192126369	0.14	Rcor3	REST corepressor 3	2008	0.23
chr11_16865620_16865819	0.14	Egfr	epidermal growth factor receptor	12431	0.2
chr14_21422563_21422878	0.14	Gm25864	predicted gene, 25864	27754	0.17
chr10_99349668_99349865	0.14	B530045E10Rik	RIKEN cDNA B530045E10 gene	50600	0.1
chr11_110249489_110249640	0.14	Abca6	ATP-binding cassette, sub-family A (ABC1), member 6	2212	0.39
chr3_93578904_93579055	0.14	S100a10	S100 calcium binding protein A10 (calpactin)	18252	0.11
chr11_11845438_11845699	0.14	Ddc	dopa decarboxylase	9288	0.18
chr5_43309511_43309822	0.14	6030400A10Rik	RIKEN cDNA 6030400A10 gene	44509	0.11
chr9_53359307_53359484	0.14	Exph5	exophilin 5	18206	0.15
chr13_101508264_101508415	0.14	Gm47533	predicted gene, 47533	36867	0.13
chr7_140720541_140720872	0.14	Olfr542-ps1	olfactory receptor 542, pseudogene 1	576	0.58
chr1_87572169_87572320	0.14	Ngef	neuronal guanine nucleotide exchange factor	1626	0.26
chr9_74964080_74964349	0.14	Fam214a	family with sequence similarity 214, member A	11142	0.2
chr19_10063756_10063907	0.14	Fads2	fatty acid desaturase 2	7356	0.13
chr12_102327592_102327745	0.14	Rin3	Ras and Rab interactor 3	27077	0.18
chr8_40270006_40270157	0.14	Fgf20	fibroblast growth factor 20	16872	0.2
chr11_16839622_16839885	0.14	Egfros	epidermal growth factor receptor, opposite strand	9051	0.21
chr1_51774175_51774474	0.14	Myo1b	myosin IB	2112	0.33
chr15_81253437_81253614	0.14	8430426J06Rik	RIKEN cDNA 8430426J06 gene	1663	0.31
chr2_8116897_8117048	0.14	Gm13254	predicted gene 13254	30893	0.26
chr8_76147308_76147459	0.14	Gm45742	predicted gene 45742	30356	0.21
chr19_12654035_12654281	0.14	Gm24521	predicted gene, 24521	11097	0.09
chr13_37601794_37602225	0.14	Gm47753	predicted gene, 47753	19738	0.1
chr16_26723002_26723153	0.14	Il1rap	interleukin 1 receptor accessory protein	643	0.79
chr13_101746510_101746927	0.14	Gm36638	predicted gene, 36638	5170	0.24
chr18_59170100_59170266	0.14	Chsy3	chondroitin sulfate synthase 3	5218	0.33
chr15_59061763_59061914	0.14	Mtss1	MTSS I-BAR domain containing 1	6374	0.24
chr9_107303087_107303371	0.14	Gm17041	predicted gene 17041	1391	0.24
chr4_108780980_108781662	0.14	Zfyve9	zinc finger, FYVE domain containing 9	523	0.73
chr1_74047166_74047356	0.14	Tns1	tensin 1	10104	0.21
chr4_63232014_63232237	0.14	Col27a1	collagen, type XXVII, alpha 1	2161	0.28
chr11_80974473_80974624	0.14	Gm11416	predicted gene 11416	72246	0.1
chr3_138455131_138455312	0.14	Adh5	alcohol dehydrogenase 5 (class III), chi polypeptide	816	0.51
chr4_150239968_150240153	0.14	Eno1	enolase 1, alpha non-neuron	2360	0.22
chr18_67648032_67648194	0.14	Psmg2	proteasome (prosome, macropain) assembly chaperone 2	6505	0.16
chr6_24262961_24263227	0.14	Slc13a1	solute carrier family 13 (sodium/sulfate symporters), member 1	95002	0.08
chr4_102557092_102557428	0.14	Pde4b	phosphodiesterase 4B, cAMP specific	12835	0.29
chr7_132924974_132925182	0.14	1500002F19Rik	RIKEN cDNA 1500002F19 gene	6025	0.15
chr12_79481989_79482309	0.14	Rad51b	RAD51 paralog B	154796	0.04
chr2_6870734_6870924	0.13	Celf2	CUGBP, Elav-like family member 2	1143	0.52

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfe2l1_Mafg

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.2	GO:0006068	ethanol catabolic process(GO:0006068)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0072592	oxygen metabolic process(GO:0072592)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.1	GO:0045726	positive regulation of integrin biosynthetic process(GO:0045726)
0.0	0.1	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.2	GO:0030035	microspike assembly(GO:0030035)
0.0	0.1	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.0	0.1	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.2	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.2	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.2	GO:0006559	L-phenylalanine catabolic process(GO:0006559) erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process(GO:1902222)
0.0	0.1	GO:0051081	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.1	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:2000302	positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.2	GO:0021540	corpus callosum morphogenesis(GO:0021540)
0.0	0.1	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.0	0.0	GO:0034770	histone H4-K20 methylation(GO:0034770)
0.0	0.1	GO:0009202	deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0030647	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
0.0	0.3	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.1	GO:0050883	musculoskeletal movement, spinal reflex action(GO:0050883)
0.0	0.1	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.1	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.0	0.1	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.1	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.1	GO:0002278	eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
0.0	0.1	GO:0006680	glucosylceramide catabolic process(GO:0006680)
0.0	0.1	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.1	GO:0097167	circadian regulation of translation(GO:0097167)
0.0	0.1	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.1	GO:0006526	arginine biosynthetic process(GO:0006526)
0.0	0.1	GO:0018317	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.1	GO:1903660	regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0	0.1	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.1	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.1	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.0	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.0	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.1	GO:0016584	nucleosome positioning(GO:0016584)
0.0	0.1	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	0.0	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.0	0.0	GO:2000807	regulation of synaptic vesicle clustering(GO:2000807)
0.0	0.0	GO:0010909	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.1	GO:0019482	beta-alanine metabolic process(GO:0019482)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.0	GO:0003162	atrioventricular node development(GO:0003162)
0.0	0.1	GO:0015781	nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.0	GO:0090158	endoplasmic reticulum membrane organization(GO:0090158)
0.0	0.0	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.0	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.0	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.0	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.0	GO:1903237	negative regulation of leukocyte tethering or rolling(GO:1903237)
0.0	0.1	GO:0052405	negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.0	GO:0070836	caveola assembly(GO:0070836)
0.0	0.0	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.1	GO:0006183	GTP biosynthetic process(GO:0006183)
0.0	0.1	GO:0046130	purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0043651	linoleic acid metabolic process(GO:0043651)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.0	GO:0042525	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0	0.0	GO:0070634	transepithelial ammonium transport(GO:0070634)
0.0	0.0	GO:0051660	establishment of centrosome localization(GO:0051660)
0.0	0.0	GO:0061002	negative regulation of dendritic spine morphogenesis(GO:0061002)
0.0	0.0	GO:1900740	regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.0	0.0	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.0	0.0	GO:0048254	snoRNA localization(GO:0048254)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.0	GO:0060161	positive regulation of dopamine receptor signaling pathway(GO:0060161)
0.0	0.1	GO:0006528	asparagine metabolic process(GO:0006528)
0.0	0.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.0	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0	0.1	GO:0006517	protein deglycosylation(GO:0006517)
0.0	0.1	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.1	GO:0071397	cellular response to cholesterol(GO:0071397)
0.0	0.0	GO:1902659	regulation of glucose mediated signaling pathway(GO:1902659) positive regulation of glucose mediated signaling pathway(GO:1902661)
0.0	0.0	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.1	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.0	0.0	GO:0006069	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.1	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.0	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.0	GO:0060468	prevention of polyspermy(GO:0060468)
0.0	0.0	GO:0071476	cellular hypotonic response(GO:0071476)
0.0	0.1	GO:0032060	bleb assembly(GO:0032060)
0.0	0.1	GO:0006002	fructose 6-phosphate metabolic process(GO:0006002)
0.0	0.1	GO:2000510	positive regulation of dendritic cell chemotaxis(GO:2000510)
0.0	0.1	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.0	GO:0030050	vesicle transport along actin filament(GO:0030050)
0.0	0.0	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.1	GO:0010519	negative regulation of phospholipase activity(GO:0010519)
0.0	0.1	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.1	GO:0006614	SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0	0.0	GO:0007621	negative regulation of female receptivity(GO:0007621)
0.0	0.0	GO:0060523	prostate epithelial cord elongation(GO:0060523)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0000322	storage vacuole(GO:0000322)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.1	GO:0042824	MHC class I peptide loading complex(GO:0042824)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.1	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.0	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.1	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.1	GO:0032389	MutLalpha complex(GO:0032389)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.1	GO:0005786	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)
0.0	0.0	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.1	GO:0044613	nuclear pore central transport channel(GO:0044613)
0.0	0.0	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.1	GO:0031428	box C/D snoRNP complex(GO:0031428)
0.0	0.0	GO:0030478	actin cap(GO:0030478)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.3	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.1	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.3	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.2	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0005047	signal recognition particle binding(GO:0005047)
0.0	0.1	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.2	GO:0016151	nickel cation binding(GO:0016151)
0.0	0.2	GO:0051920	peroxiredoxin activity(GO:0051920)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0050510	N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.0	0.1	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.1	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.0	0.1	GO:0047023	androsterone dehydrogenase activity(GO:0047023)
0.0	0.0	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.0	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.1	GO:0070699	type II activin receptor binding(GO:0070699)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0	0.2	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.0	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.0	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.1	GO:0005025	transforming growth factor beta receptor activity, type I(GO:0005025)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0000403	Y-form DNA binding(GO:0000403)
0.0	0.1	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:1990239	steroid hormone binding(GO:1990239)
0.0	0.0	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0004839	ubiquitin activating enzyme activity(GO:0004839)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.0	GO:0000295	adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	0.3	GO:0005070	SH3/SH2 adaptor activity(GO:0005070)
0.0	0.0	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.1	GO:0015377	cation:chloride symporter activity(GO:0015377)
0.0	0.1	GO:0004673	protein histidine kinase activity(GO:0004673)
0.0	0.0	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0016863	intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.0	0.0	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0	0.0	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.0	GO:0004487	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0	0.0	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.0	0.1	GO:0004075	biotin carboxylase activity(GO:0004075)
0.0	0.0	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.0	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.1	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.4	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.3	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.1	REACTOME ER PHAGOSOME PATHWAY	Genes involved in ER-Phagosome pathway
0.3	REACTOME GRB2 EVENTS IN ERBB2 SIGNALING	Genes involved in GRB2 events in ERBB2 signaling
0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.1	REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1	REACTOME PROLONGED ERK ACTIVATION EVENTS	Genes involved in Prolonged ERK activation events
0.1	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway

Results for Nfe2l1_Mafg

Z-value: 0.98

Motif logo

Transcription factors associated with Nfe2l1_Mafg

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Nfe2l1_Mafg motif across conditions

Conditions sorted by the z-value of the Nfe2l1_Mafg motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfe2l1_Mafg

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: