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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Nfe2l2

Z-value: 0.76

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Transcription factors associated with Nfe2l2

Gene Symbol	Gene ID	Gene Info
Nfe2l2 Ensembl NCBI MGI UniProt	ENSMUSG00000015839.6	Nfe2l2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Nfe2l2	chr2_75698638_75698789	5776	0.129144	-0.92	9.5e-03	Click!
Nfe2l2	chr2_75696217_75696368	8197	0.121140	-0.89	1.8e-02	Click!
Nfe2l2	chr2_75699304_75699580	5047	0.133232	-0.89	1.8e-02	Click!
Nfe2l2	chr2_75698077_75698279	6311	0.126848	-0.87	2.3e-02	Click!
Nfe2l2	chr2_75697788_75697939	6626	0.125689	-0.85	3.1e-02	Click!

Activity of the Nfe2l2 motif across conditions

Conditions sorted by the z-value of the Nfe2l2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr11_7201124_7201275	1.50	Igfbp1	insulin-like growth factor binding protein 1	3417	0.21
chr5_139871644_139871802	0.58	Gm42423	predicted gene 42423	24086	0.12
chr16_28991322_28991483	0.54	Gm8253	predicted gene 8253	40047	0.19
chr16_30590365_30590575	0.54	Lsg1	large 60S subunit nuclear export GTPase 1	2878	0.26
chr6_31066838_31067230	0.52	Gm27019	predicted gene, 27019	3539	0.14
chr1_92683263_92683419	0.49	Gm29483	predicted gene 29483	33861	0.09
chr5_134941937_134942100	0.46	Mettl27	methyltransferase like 27	1556	0.18
chr19_42118558_42118858	0.46	Pi4k2a	phosphatidylinositol 4-kinase type 2 alpha	4030	0.13
chr16_38711344_38711500	0.45	Arhgap31	Rho GTPase activating protein 31	1476	0.34
chr15_102014961_102015124	0.44	Krt8	keratin 8	10560	0.11
chr14_62465117_62465312	0.43	Gucy1b2	guanylate cyclase 1, soluble, beta 2	8925	0.16
chr9_69356418_69356569	0.43	Gm15511	predicted gene 15511	7754	0.19
chr10_84701256_84701556	0.43	Rfx4	regulatory factor X, 4 (influences HLA class II expression)	54656	0.1
chr8_126844756_126844953	0.43	A630001O12Rik	RIKEN cDNA A630001O12 gene	5621	0.22
chr10_127915625_127915914	0.42	Gm15905	predicted gene 15905	5300	0.1
chr9_118101918_118102083	0.41	Azi2	5-azacytidine induced gene 2	42944	0.13
chrY_90769047_90769393	0.41	Gm21860	predicted gene, 21860	13753	0.16
chr4_33243933_33244238	0.38	Pnrc1	proline-rich nuclear receptor coactivator 1	3490	0.21
chr10_107943872_107944134	0.38	Gm29685	predicted gene, 29685	2642	0.35
chr3_104531244_104531395	0.38	Lrig2	leucine-rich repeats and immunoglobulin-like domains 2	19401	0.12
chr9_43622435_43622586	0.37	Gm29909	predicted gene, 29909	14326	0.17
chr14_69728721_69728885	0.37	Chmp7	charged multivesicular body protein 7	2072	0.22
chr2_132212432_132212583	0.37	Tmem230	transmembrane protein 230	35147	0.11
chr19_37528710_37528861	0.37	Exoc6	exocyst complex component 6	7906	0.2
chr13_64388507_64388698	0.36	Ctsl	cathepsin L	17712	0.1
chr17_31874093_31874279	0.36	Sik1	salt inducible kinase 1	18382	0.13
chr16_21828430_21828584	0.36	Map3k13	mitogen-activated protein kinase kinase kinase 13	2565	0.18
chr10_20673746_20674078	0.36	Gm17230	predicted gene 17230	48277	0.14
chr10_93188458_93188632	0.36	Cdk17	cyclin-dependent kinase 17	6935	0.21
chr5_130264636_130264798	0.36	Tyw1	tRNA-yW synthesizing protein 1 homolog (S. cerevisiae)	5787	0.13
chr19_23033456_23033617	0.36	Gm50136	predicted gene, 50136	27918	0.18
chr6_121886736_121886887	0.35	Mug1	murinoglobulin 1	1234	0.47
chr16_76237397_76237728	0.35	Nrip1	nuclear receptor interacting protein 1	86096	0.08
chr1_192061757_192061908	0.35	Traf5	TNF receptor-associated factor 5	2670	0.19
chr14_47354165_47354327	0.34	Lgals3	lectin, galactose binding, soluble 3	13505	0.1
chr16_21828238_21828402	0.34	Map3k13	mitogen-activated protein kinase kinase kinase 13	2378	0.19
chr14_31496236_31496433	0.33	Eaf1	ELL associated factor 1	1138	0.32
chr16_77569572_77569736	0.33	Gm37606	predicted gene, 37606	8004	0.11
chr4_139334725_139334887	0.33	AL807811.1	aldo-keto reductase family 7 member A2 (AKR7A2) pseudogene	2374	0.12
chr1_153502177_153502328	0.33	Dhx9	DEAH (Asp-Glu-Ala-His) box polypeptide 9	14592	0.16
chr4_46563917_46564068	0.32	Coro2a	coronin, actin binding protein 2A	2448	0.24
chr2_35066631_35066785	0.32	Hc	hemolytic complement	5270	0.18
chr14_78937878_78938029	0.32	Gm49016	predicted gene, 49016	9274	0.2
chr12_84202016_84202416	0.32	Gm31513	predicted gene, 31513	6247	0.11
chr12_54671337_54671527	0.32	Gm24971	predicted gene, 24971	4646	0.08
chr3_67490227_67490388	0.32	Gm42568	predicted gene 42568	13329	0.13
chr12_29100151_29100321	0.31	4833405L11Rik	RIKEN cDNA 4833405L11 gene	6501	0.24
chr12_110381296_110381622	0.31	Gm47195	predicted gene, 47195	56074	0.08
chr10_84854177_84854328	0.31	Rfx4	regulatory factor X, 4 (influences HLA class II expression)	16104	0.21
chr11_115437682_115437852	0.31	Trim80	tripartite motif-containing 80	2778	0.11
chr11_61263826_61264208	0.31	Aldh3a2	aldehyde dehydrogenase family 3, subfamily A2	1682	0.33
chr3_85991904_85992061	0.30	Prss48	protease, serine 48	10509	0.12
chr16_31430067_31430241	0.30	Gm15743	predicted gene 15743	378	0.68
chr13_34898393_34898709	0.30	Prpf4b	pre-mRNA processing factor 4B	3098	0.15
chr9_94993496_94993650	0.30	Gm47168	predicted gene, 47168	889	0.73
chr11_22269235_22269425	0.30	Ehbp1	EH domain binding protein 1	16508	0.26
chr11_116079675_116079864	0.30	Wbp2	WW domain binding protein 2	1716	0.19
chr2_12197838_12198004	0.30	Itga8	integrin alpha 8	4609	0.27
chr6_8345541_8345704	0.30	Gm16055	predicted gene 16055	18514	0.17
chr9_119405710_119405861	0.29	Gm47320	predicted gene, 47320	3231	0.15
chr8_71405094_71405257	0.29	Ankle1	ankyrin repeat and LEM domain containing 1	835	0.39
chr8_68908746_68908916	0.29	Lpl	lipoprotein lipase	18087	0.18
chr15_100625793_100625948	0.29	Dazap2	DAZ associated protein 2	9538	0.08
chr8_69896581_69896741	0.29	Yjefn3	YjeF N-terminal domain containing 3	2686	0.15
chr7_35127036_35127350	0.28	Gm45091	predicted gene 45091	7588	0.1
chr13_93627456_93627944	0.28	Gm15622	predicted gene 15622	2318	0.25
chr5_145989518_145989698	0.28	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	2035	0.23
chr2_101781393_101781544	0.28	Prr5l	proline rich 5 like	16182	0.23
chr10_108612751_108612908	0.28	Syt1	synaptotagmin I	24135	0.23
chr12_21141056_21141213	0.27	Asap2	ArfGAP with SH3 domain, ankyrin repeat and PH domain 2	29180	0.17
chr2_144182222_144182616	0.27	Gm5535	predicted gene 5535	3333	0.2
chr9_107689065_107689227	0.27	Sema3f	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3F	771	0.43
chr11_117965286_117965456	0.27	Socs3	suppressor of cytokine signaling 3	3815	0.17
chr2_104130173_104130336	0.27	A930018P22Rik	RIKEN cDNA A930018P22 gene	7485	0.14
chr8_45255175_45255326	0.27	F11	coagulation factor XI	6781	0.18
chr10_18399536_18399687	0.27	Nhsl1	NHS-like 1	8027	0.24
chr12_80598944_80599110	0.27	Galnt16	polypeptide N-acetylgalactosaminyltransferase 16	924	0.35
chr14_8356958_8357137	0.27	2610318M16Rik	RIKEN cDNA 2610318M16 gene	10393	0.18
chr4_70499390_70499541	0.27	Megf9	multiple EGF-like-domains 9	35463	0.22
chr15_3353815_3354005	0.27	Ccdc152	coiled-coil domain containing 152	50384	0.15
chr1_63479013_63479186	0.27	Adam23	a disintegrin and metallopeptidase domain 23	8480	0.22
chr18_20989752_20989946	0.27	Rnf138	ring finger protein 138	11492	0.2
chr11_58931646_58931797	0.27	Rnf187	ring finger protein 187	7195	0.07
chr15_6748493_6748644	0.26	Rictor	RPTOR independent companion of MTOR, complex 2	40185	0.16
chr15_77412067_77412222	0.26	Apol9a	apolipoprotein L 9a	1009	0.35
chr16_95814866_95815042	0.26	2810404F17Rik	RIKEN cDNA 2810404F17 gene	6637	0.19
chr18_20782566_20782759	0.26	B4galt6	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6	36258	0.15
chr18_46381013_46381189	0.26	Gm24617	predicted gene, 24617	13736	0.14
chr11_53764208_53764367	0.26	Mir7671	microRNA 7671	633	0.56
chr1_75660295_75660569	0.26	Gm5257	predicted gene 5257	24042	0.16
chr10_77970592_77970747	0.26	Trpm2	transient receptor potential cation channel, subfamily M, member 2	106	0.94
chr2_59884229_59884405	0.26	Wdsub1	WD repeat, SAM and U-box domain containing 1	1726	0.39
chr8_89279548_89279868	0.26	Gm5356	predicted pseudogene 5356	92148	0.09
chr13_56324320_56324471	0.26	Gm17878	predicted gene, 17878	4061	0.17
chr11_7203353_7203538	0.26	Igfbp1	insulin-like growth factor binding protein 1	5663	0.18
chr18_23805749_23805916	0.26	Mapre2	microtubule-associated protein, RP/EB family, member 2	1729	0.33
chr16_37856387_37856547	0.26	Gm36028	predicted gene, 36028	39	0.96
chr19_3850170_3850502	0.26	Chka	choline kinase alpha	1437	0.22
chr6_145679594_145679775	0.26	Tuba3b	tubulin, alpha 3B	63927	0.09
chr15_36904059_36904218	0.25	Gm10384	predicted gene 10384	24322	0.13
chr8_102024599_102024751	0.25	Gm22223	predicted gene, 22223	484967	0.01
chr4_45503959_45504122	0.25	Gm22518	predicted gene, 22518	3488	0.2
chr1_131546654_131546962	0.25	Fam72a	family with sequence similarity 72, member A	18905	0.14
chr7_24850950_24851109	0.25	Gm18207	predicted gene, 18207	9917	0.09
chr5_145852474_145852695	0.25	Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	24107	0.13
chr5_145989114_145989402	0.25	Cyp3a25	cytochrome P450, family 3, subfamily a, polypeptide 25	2385	0.2
chr7_25387916_25388067	0.25	Lipe	lipase, hormone sensitive	1233	0.27
chr13_39452515_39452666	0.25	Gm47348	predicted gene, 47348	12025	0.18
chr15_6882089_6882243	0.25	Osmr	oncostatin M receptor	7197	0.29
chr13_10274143_10274314	0.24	Gm26861	predicted gene, 26861	83367	0.08
chr11_64588556_64588707	0.24	Gm24275	predicted gene, 24275	2009	0.47
chr14_73105205_73105370	0.24	Rcbtb2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	17750	0.19
chr18_12882054_12882208	0.24	Osbpl1a	oxysterol binding protein-like 1A	2154	0.28
chr10_24097646_24097797	0.24	Taar8c	trace amine-associated receptor 8C	4191	0.1
chr4_115607059_115607329	0.24	Cyp4a32	cytochrome P450, family 4, subfamily a, polypeptide 32	6219	0.14
chr1_180219669_180219845	0.24	Gm37336	predicted gene, 37336	7356	0.14
chr14_51106134_51106584	0.24	Eddm3b	epididymal protein 3B	8067	0.08
chr5_148674254_148674405	0.24	Gm36186	predicted gene, 36186	37137	0.13
chr14_37134902_37135213	0.24	Ghitm	growth hormone inducible transmembrane protein	82	0.97
chr1_155108763_155108914	0.24	Ier5	immediate early response 5	9202	0.15
chr8_75089591_75089759	0.24	Hmox1	heme oxygenase 1	3946	0.16
chr5_17854594_17854745	0.24	Cd36	CD36 molecule	4877	0.33
chr14_20135347_20135503	0.23	Saysd1	SAYSVFN motif domain containing 1	3109	0.21
chr16_32685796_32686168	0.23	Tnk2	tyrosine kinase, non-receptor, 2	5168	0.16
chr14_24232675_24232832	0.23	Gm17105	predicted gene 17105	10638	0.13
chr19_6273750_6273958	0.23	Gm14963	predicted gene 14963	2751	0.1
chr13_59875722_59876043	0.23	Gm48384	predicted gene, 48384	2240	0.23
chr15_99814958_99815109	0.23	Gm17057	predicted gene 17057	3987	0.1
chr4_41637175_41637517	0.23	Gm12406	predicted gene 12406	2032	0.17
chr5_36563902_36564053	0.23	Tbc1d14	TBC1 domain family, member 14	79	0.97
chr11_7196610_7196788	0.23	Igfbp1	insulin-like growth factor binding protein 1	1083	0.48
chr19_6932250_6932483	0.23	Kcnk4	potassium channel, subfamily K, member 4	461	0.58
chr8_11005778_11005929	0.23	9530052E02Rik	RIKEN cDNA 9530052E02 gene	1997	0.22
chr16_16543014_16543174	0.23	Gm16139	predicted gene 16139	771	0.66
chr2_92667342_92667493	0.23	Chst1	carbohydrate sulfotransferase 1	67710	0.08
chr2_154591324_154591483	0.22	Pxmp4	peroxisomal membrane protein 4	12285	0.1
chr5_90433544_90433714	0.22	Alb	albumin	27268	0.13
chr8_116344914_116345106	0.22	1700018P08Rik	RIKEN cDNA 1700018P08 gene	12051	0.29
chr3_41031529_41031708	0.22	Larp1b	La ribonucleoprotein domain family, member 1B	1897	0.27
chr2_44142320_44142937	0.22	Arhgap15os	Rho GTPase activating protein 15, opposite strand	77304	0.11
chr9_23030248_23030409	0.22	Bmper	BMP-binding endothelial regulator	192748	0.03
chr16_94530638_94530789	0.22	Vps26c	VPS26 endosomal protein sorting factor C	3883	0.21
chr1_170709591_170709775	0.22	Gm23523	predicted gene, 23523	42140	0.12
chr14_73388637_73388820	0.22	Itm2b	integral membrane protein 2B	3439	0.26
chr1_97672950_97673101	0.22	D1Ertd622e	DNA segment, Chr 1, ERATO Doi 622, expressed	10951	0.19
chr15_59799636_59799788	0.22	Gm19510	predicted gene, 19510	4753	0.3
chr12_111454567_111454858	0.22	Tnfaip2	tumor necrosis factor, alpha-induced protein 2	4193	0.14
chr17_3489197_3489361	0.22	Tiam2	T cell lymphoma invasion and metastasis 2	1184	0.47
chr19_4441877_4442205	0.22	A930001C03Rik	RIKEN cDNA A930001C03 gene	1697	0.23
chr9_62435632_62436065	0.22	Coro2b	coronin, actin binding protein, 2B	6598	0.24
chr16_95682151_95682417	0.22	Ets2	E26 avian leukemia oncogene 2, 3' domain	19791	0.2
chr11_12197671_12197822	0.22	Gm12001	predicted gene 12001	69748	0.11
chr15_77727954_77728108	0.22	Apol9b	apolipoprotein L 9b	1008	0.34
chr9_50590889_50591040	0.22	Sdhd	succinate dehydrogenase complex, subunit D, integral membrane protein	12848	0.09
chr8_12882911_12883062	0.22	Gm15353	predicted gene 15353	730	0.53
chr2_126591444_126591598	0.22	Hdc	histidine decarboxylase	6740	0.18
chr9_31610718_31610869	0.22	Gm18820	predicted gene, 18820	32977	0.14
chr5_131814532_131814871	0.21	4930563F08Rik	RIKEN cDNA 4930563F08 gene	65568	0.08
chr17_69181315_69181466	0.21	Epb41l3	erythrocyte membrane protein band 4.1 like 3	24532	0.23
chr4_80922189_80922362	0.21	Lurap1l	leucine rich adaptor protein 1-like	11629	0.25
chr9_95549721_95549889	0.21	Gm32281	predicted gene, 32281	4692	0.15
chr4_130075213_130075370	0.21	Col16a1	collagen, type XVI, alpha 1	1752	0.29
chr16_32853567_32853731	0.21	Rubcn	RUN domain and cysteine-rich domain containing, Beclin 1-interacting protein	14689	0.12
chr8_126686853_126687025	0.21	Gm45805	predicted gene 45805	71395	0.1
chr8_126778914_126779065	0.21	Gm45805	predicted gene 45805	20655	0.21
chr12_83055899_83056080	0.21	Rgs6	regulator of G-protein signaling 6	8999	0.21
chr13_64237836_64238013	0.21	Cdc14b	CDC14 cell division cycle 14B	10718	0.1
chr16_21792922_21793081	0.21	1300002E11Rik	RIKEN cDNA 1300002E11 gene	1317	0.26
chr12_31913746_31913916	0.21	Cog5	component of oligomeric golgi complex 5	5842	0.2
chr6_117604955_117605122	0.21	Gm45083	predicted gene 45083	7532	0.22
chr16_11456411_11456595	0.21	Snx29	sorting nexin 29	9195	0.23
chr10_81181035_81181199	0.21	Eef2	eukaryotic translation elongation factor 2	66	0.9
chr11_62568400_62568605	0.20	Gm12280	predicted gene 12280	2119	0.14
chr16_22108220_22108385	0.20	Igf2bp2	insulin-like growth factor 2 mRNA binding protein 2	12934	0.18
chr11_86951820_86952000	0.20	Ypel2	yippee like 2	20114	0.17
chr8_123162810_123162969	0.20	Gm4316	predicted gene 4316	2366	0.12
chr11_101361469_101361620	0.20	AL590969.1	glucose-6-phosphatase, catalytic (G6pc) pseudogene	5169	0.06
chr5_100663119_100663274	0.20	Coq2	coenzyme Q2 4-hydroxybenzoate polyprenyltransferase	1223	0.4
chr7_138867340_138867520	0.20	Ppp2r2d	protein phosphatase 2, regulatory subunit B, delta	980	0.43
chr18_38849992_38850159	0.20	Fgf1	fibroblast growth factor 1	8673	0.22
chr15_43701477_43701832	0.20	Gm2140	predicted gene 2140	106807	0.07
chr11_44172606_44172757	0.20	Gm12154	predicted gene 12154	94528	0.08
chr9_58231879_58232044	0.20	Pml	promyelocytic leukemia	1424	0.27
chr15_100227160_100227326	0.20	Atf1	activating transcription factor 1	576	0.67
chr18_11035510_11035780	0.20	Gata6os	GATA binding protein 6, opposite strand	11992	0.21
chr12_60292738_60292905	0.20	Gm32936	predicted gene, 32936	25067	0.2
chr3_98044919_98045386	0.20	Gm42819	predicted gene 42819	14465	0.18
chr8_10910475_10910817	0.20	Gm2814	predicted gene 2814	10088	0.1
chr2_163661430_163661594	0.20	Pkig	protein kinase inhibitor, gamma	13	0.97
chr11_101953099_101953306	0.20	4930417O22Rik	RIKEN cDNA 4930417O22 gene	781	0.45
chr19_4213519_4213699	0.20	Clcf1	cardiotrophin-like cytokine factor 1	629	0.3
chr4_115610472_115610686	0.20	Cyp4a32	cytochrome P450, family 4, subfamily a, polypeptide 32	9604	0.13
chr5_92867642_92867801	0.20	Shroom3	shroom family member 3	11250	0.22
chr8_94172420_94173095	0.20	Mt2	metallothionein 2	93	0.88
chr1_191421012_191421174	0.20	Gm2272	predicted gene 2272	13427	0.14
chr9_59487560_59487714	0.20	Arih1	ariadne RBR E3 ubiquitin protein ligase 1	1019	0.47
chr11_103689147_103689298	0.20	Gosr2	golgi SNAP receptor complex member 2	8472	0.13
chr6_97962459_97962619	0.20	Mitf	melanogenesis associated transcription factor	21621	0.24
chr15_76552804_76552973	0.20	Slc52a2	solute carrier protein 52, member 2	13924	0.06
chr15_85626555_85626706	0.20	Gm49539	predicted gene, 49539	19453	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nfe2l2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.1	0.1	GO:0021886	hypothalamus gonadotrophin-releasing hormone neuron differentiation(GO:0021886) hypothalamus gonadotrophin-releasing hormone neuron development(GO:0021888)
0.1	0.3	GO:1903626	positive regulation of apoptotic DNA fragmentation(GO:1902512) positive regulation of DNA catabolic process(GO:1903626)
0.1	0.2	GO:0060137	maternal process involved in parturition(GO:0060137)
0.1	0.2	GO:2000857	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
0.1	0.1	GO:0016095	polyprenol catabolic process(GO:0016095)
0.1	0.2	GO:0001543	ovarian follicle rupture(GO:0001543)
0.1	0.3	GO:0009115	xanthine catabolic process(GO:0009115)
0.1	0.3	GO:0052805	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0071502	cellular response to temperature stimulus(GO:0071502)
0.0	0.1	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.0	0.2	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.1	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0	0.1	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.2	GO:0097491	trunk segmentation(GO:0035290) trunk neural crest cell migration(GO:0036484) ventral trunk neural crest cell migration(GO:0036486) sympathetic neuron projection extension(GO:0097490) sympathetic neuron projection guidance(GO:0097491)
0.0	0.2	GO:2000767	positive regulation of cytoplasmic translation(GO:2000767)
0.0	0.2	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.2	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.1	GO:0045196	establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
0.0	0.1	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0019747	regulation of isoprenoid metabolic process(GO:0019747)
0.0	0.1	GO:0045897	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.1	GO:0018916	nitrobenzene metabolic process(GO:0018916)
0.0	0.1	GO:2000721	positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
0.0	0.1	GO:0009093	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0002432	granuloma formation(GO:0002432)
0.0	0.1	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.1	GO:0015744	succinate transport(GO:0015744)
0.0	0.1	GO:0018992	germ-line sex determination(GO:0018992)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.1	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.0	0.2	GO:0071442	positive regulation of histone H3-K14 acetylation(GO:0071442)
0.0	0.2	GO:2000480	negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.0	0.1	GO:0070340	detection of bacterial lipopeptide(GO:0070340)
0.0	0.1	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:2001170	negative regulation of ATP biosynthetic process(GO:2001170)
0.0	0.2	GO:0070544	histone H3-K36 demethylation(GO:0070544)
0.0	0.1	GO:1902744	negative regulation of lamellipodium organization(GO:1902744)
0.0	0.1	GO:0046341	CDP-diacylglycerol metabolic process(GO:0046341)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.6	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.1	GO:1902730	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.2	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
0.0	0.1	GO:0006362	transcription elongation from RNA polymerase I promoter(GO:0006362)
0.0	0.1	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
0.0	0.1	GO:1901679	nucleotide transmembrane transport(GO:1901679)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.2	GO:0000185	activation of MAPKKK activity(GO:0000185)
0.0	0.1	GO:1990169	detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.0	0.0	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0	0.1	GO:0045404	positive regulation of interleukin-4 biosynthetic process(GO:0045404)
0.0	0.1	GO:0031443	fast-twitch skeletal muscle fiber contraction(GO:0031443)
0.0	0.1	GO:0048295	positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.0	0.0	GO:0016259	selenocysteine metabolic process(GO:0016259)
0.0	0.2	GO:0090557	establishment of endothelial intestinal barrier(GO:0090557)
0.0	0.1	GO:0090210	regulation of establishment of blood-brain barrier(GO:0090210)
0.0	0.1	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0	0.1	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:0009212	dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.1	GO:2000468	regulation of peroxidase activity(GO:2000468)
0.0	0.2	GO:0032933	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0032792	negative regulation of CREB transcription factor activity(GO:0032792)
0.0	0.1	GO:0070417	cellular response to cold(GO:0070417)
0.0	0.1	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.0	GO:2000598	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.0	0.0	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.1	GO:0010886	positive regulation of cholesterol storage(GO:0010886)
0.0	0.1	GO:0034093	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.1	GO:0060057	apoptotic process involved in mammary gland involution(GO:0060057) positive regulation of apoptotic process involved in mammary gland involution(GO:0060058) positive regulation of apoptotic process involved in morphogenesis(GO:1902339) regulation of mammary gland involution(GO:1903519) positive regulation of mammary gland involution(GO:1903521) positive regulation of apoptotic process involved in development(GO:1904747)
0.0	0.1	GO:0035630	bone mineralization involved in bone maturation(GO:0035630)
0.0	0.1	GO:1904417	regulation of xenophagy(GO:1904415) positive regulation of xenophagy(GO:1904417)
0.0	0.0	GO:0002085	inhibition of neuroepithelial cell differentiation(GO:0002085) negative regulation of auditory receptor cell differentiation(GO:0045608)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.0	GO:0071225	cellular response to muramyl dipeptide(GO:0071225)
0.0	0.1	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.0	0.1	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.0	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:0006361	transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0	0.1	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.2	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.1	GO:0051189	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.3	GO:0035278	miRNA mediated inhibition of translation(GO:0035278)
0.0	0.0	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0	0.1	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0	0.1	GO:0014045	establishment of endothelial blood-brain barrier(GO:0014045)
0.0	0.1	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.1	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.0	0.0	GO:0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296)
0.0	0.0	GO:2000491	positive regulation of hepatic stellate cell activation(GO:2000491)
0.0	0.1	GO:0006287	base-excision repair, gap-filling(GO:0006287)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.1	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.1	GO:1902510	regulation of apoptotic DNA fragmentation(GO:1902510)
0.0	0.1	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.1	GO:2000850	negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.0	0.1	GO:0010424	DNA methylation on cytosine within a CG sequence(GO:0010424) DNA methylation on cytosine(GO:0032776)
0.0	0.1	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.1	GO:0042732	D-xylose metabolic process(GO:0042732)
0.0	0.1	GO:0006742	NADP catabolic process(GO:0006742)
0.0	0.1	GO:0098902	regulation of membrane depolarization during action potential(GO:0098902)
0.0	0.1	GO:0050812	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.0	0.1	GO:0035733	hepatic stellate cell activation(GO:0035733) regulation of hepatic stellate cell activation(GO:2000489)
0.0	0.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.0	GO:1902548	negative regulation of cellular response to vascular endothelial growth factor stimulus(GO:1902548)
0.0	0.0	GO:0021593	rhombomere morphogenesis(GO:0021593)
0.0	0.1	GO:0048170	positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.0	0.0	GO:0043382	positive regulation of memory T cell differentiation(GO:0043382)
0.0	0.1	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.0	GO:0002835	negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
0.0	0.1	GO:0010940	positive regulation of necrotic cell death(GO:0010940)
0.0	0.0	GO:0072061	inner medullary collecting duct development(GO:0072061)
0.0	0.0	GO:0009436	glyoxylate catabolic process(GO:0009436)
0.0	0.1	GO:0072262	metanephric glomerular mesangium development(GO:0072223) metanephric glomerular mesangial cell proliferation involved in metanephros development(GO:0072262)
0.0	0.0	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.1	GO:0009957	epidermal cell fate specification(GO:0009957)
0.0	0.1	GO:0001842	neural fold formation(GO:0001842)
0.0	0.1	GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell(GO:0002291)
0.0	0.0	GO:1903849	regulation of aorta morphogenesis(GO:1903847) positive regulation of aorta morphogenesis(GO:1903849)
0.0	0.0	GO:0043553	negative regulation of phosphatidylinositol 3-kinase activity(GO:0043553)
0.0	0.2	GO:0009083	branched-chain amino acid catabolic process(GO:0009083)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:2000059	negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0	0.0	GO:1905065	positive regulation of vascular smooth muscle cell differentiation(GO:1905065)
0.0	0.0	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.1	GO:0070389	chaperone cofactor-dependent protein refolding(GO:0070389)
0.0	0.0	GO:1904502	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0	0.0	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.0	GO:0002086	diaphragm contraction(GO:0002086)
0.0	0.1	GO:0051365	cellular response to potassium ion starvation(GO:0051365)
0.0	0.1	GO:0090286	cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.0	0.0	GO:0097503	sialylation(GO:0097503)
0.0	0.0	GO:1903238	positive regulation of leukocyte tethering or rolling(GO:1903238)
0.0	0.0	GO:0006216	cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087)
0.0	0.0	GO:0007403	glial cell fate determination(GO:0007403)
0.0	0.0	GO:0003347	epicardial cell to mesenchymal cell transition(GO:0003347)
0.0	0.1	GO:0045039	protein import into mitochondrial inner membrane(GO:0045039)
0.0	0.0	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.1	GO:0002934	desmosome organization(GO:0002934)
0.0	0.0	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.0	GO:0006624	vacuolar protein processing(GO:0006624)
0.0	0.0	GO:2000645	negative regulation of receptor catabolic process(GO:2000645)
0.0	0.1	GO:0003241	growth involved in heart morphogenesis(GO:0003241)
0.0	0.1	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.0	0.1	GO:0007221	positive regulation of transcription of Notch receptor target(GO:0007221)
0.0	0.0	GO:0030242	pexophagy(GO:0030242)
0.0	0.0	GO:0002901	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0	0.1	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.1	GO:0046102	inosine metabolic process(GO:0046102)
0.0	0.0	GO:0045472	response to ether(GO:0045472)
0.0	0.1	GO:0046475	glycerophospholipid catabolic process(GO:0046475)
0.0	0.0	GO:0007227	signal transduction downstream of smoothened(GO:0007227) positive regulation of hh target transcription factor activity(GO:0007228)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.0	GO:0045794	negative regulation of cell volume(GO:0045794)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.0	GO:2000504	positive regulation of blood vessel remodeling(GO:2000504)
0.0	0.0	GO:0051572	negative regulation of histone H3-K4 methylation(GO:0051572)
0.0	0.2	GO:0007190	activation of adenylate cyclase activity(GO:0007190)
0.0	0.0	GO:0071651	positive regulation of chemokine (C-C motif) ligand 5 production(GO:0071651)
0.0	0.0	GO:0006933	negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.0	0.2	GO:0051601	exocyst localization(GO:0051601)
0.0	0.0	GO:0061687	detoxification of inorganic compound(GO:0061687)
0.0	0.1	GO:0060298	positive regulation of sarcomere organization(GO:0060298)
0.0	0.0	GO:0086042	cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042)
0.0	0.0	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.1	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)
0.0	0.0	GO:0030950	establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0	0.2	GO:0043518	negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518)
0.0	0.0	GO:0036015	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.1	GO:0042983	amyloid precursor protein biosynthetic process(GO:0042983) regulation of amyloid precursor protein biosynthetic process(GO:0042984)
0.0	0.1	GO:0071267	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.0	GO:0006285	base-excision repair, AP site formation(GO:0006285)
0.0	0.0	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.0	GO:0034238	macrophage fusion(GO:0034238) regulation of macrophage fusion(GO:0034239)
0.0	0.0	GO:2000321	positive regulation of T-helper 17 cell differentiation(GO:2000321)
0.0	0.0	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.0	0.0	GO:1904707	positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.0	0.1	GO:0070561	vitamin D receptor signaling pathway(GO:0070561)
0.0	0.1	GO:0060670	branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.0	0.0	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205)
0.0	0.0	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.0	GO:0061158	3'-UTR-mediated mRNA destabilization(GO:0061158)
0.0	0.0	GO:0019064	fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
0.0	0.0	GO:0061038	uterus morphogenesis(GO:0061038)
0.0	0.1	GO:2000676	positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0	0.0	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:2001223	negative regulation of neuron migration(GO:2001223)
0.0	0.1	GO:0006384	transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0	0.1	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
0.0	0.0	GO:0050713	negative regulation of interleukin-1 beta secretion(GO:0050713)
0.0	0.0	GO:0034392	negative regulation of smooth muscle cell apoptotic process(GO:0034392)
0.0	0.1	GO:0060484	lung-associated mesenchyme development(GO:0060484)
0.0	0.1	GO:0005513	detection of calcium ion(GO:0005513)
0.0	0.0	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.0	0.0	GO:0048023	positive regulation of melanin biosynthetic process(GO:0048023) positive regulation of secondary metabolite biosynthetic process(GO:1900378)
0.0	0.0	GO:1902896	terminal web assembly(GO:1902896)
0.0	0.0	GO:0032348	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	0.0	GO:0006391	transcription initiation from mitochondrial promoter(GO:0006391)
0.0	0.0	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.0	GO:0009794	regulation of mitotic cell cycle, embryonic(GO:0009794) mitotic cell cycle, embryonic(GO:0045448)
0.0	0.1	GO:0038063	collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0	0.0	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.0	GO:0032817	regulation of natural killer cell proliferation(GO:0032817) positive regulation of natural killer cell proliferation(GO:0032819)
0.0	0.0	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.1	GO:0097067	cellular response to thyroid hormone stimulus(GO:0097067)
0.0	0.0	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.1	GO:0003105	negative regulation of glomerular filtration(GO:0003105)
0.0	0.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.0	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.0	0.1	GO:0031507	heterochromatin assembly(GO:0031507)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.0	GO:0071725	response to triacyl bacterial lipopeptide(GO:0071725) cellular response to triacyl bacterial lipopeptide(GO:0071727)
0.0	0.0	GO:0051599	response to hydrostatic pressure(GO:0051599)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.1	0.2	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.0	0.1	GO:0035838	growing cell tip(GO:0035838)
0.0	0.1	GO:0035355	Toll-like receptor 2-Toll-like receptor 6 protein complex(GO:0035355)
0.0	0.1	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.2	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.0	0.1	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.1	GO:1990462	omegasome(GO:1990462)
0.0	0.1	GO:0005606	laminin-1 complex(GO:0005606)
0.0	0.2	GO:0005577	fibrinogen complex(GO:0005577)
0.0	0.2	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.2	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.0	GO:0035061	interchromatin granule(GO:0035061)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.3	GO:0000145	exocyst(GO:0000145)
0.0	0.1	GO:0097255	R2TP complex(GO:0097255)
0.0	0.1	GO:0030915	Smc5-Smc6 complex(GO:0030915)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.1	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.2	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.1	GO:0005767	secondary lysosome(GO:0005767)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.0	GO:0031523	Myb complex(GO:0031523)
0.0	0.2	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0044327	dendritic spine head(GO:0044327)
0.0	0.0	GO:0034673	inhibin-betaglycan-ActRII complex(GO:0034673)
0.0	0.1	GO:0032591	dendritic spine membrane(GO:0032591)
0.0	0.1	GO:0032584	growth cone membrane(GO:0032584)
0.0	0.1	GO:0005587	collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) basement membrane collagen trimer(GO:0098651)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.0	GO:0097451	glial limiting end-foot(GO:0097451)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.0	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.0	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.1	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	0.0	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.1	GO:0034045	pre-autophagosomal structure membrane(GO:0034045)
0.0	0.0	GO:0009279	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.0	GO:0031262	Ndc80 complex(GO:0031262)
0.0	0.0	GO:0035363	histone locus body(GO:0035363)
0.0	0.0	GO:0005745	m-AAA complex(GO:0005745)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	0.3	GO:0030151	molybdenum ion binding(GO:0030151)
0.1	0.2	GO:0050220	prostaglandin-E synthase activity(GO:0050220)
0.1	0.3	GO:0008390	testosterone 16-alpha-hydroxylase activity(GO:0008390)
0.1	0.2	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.1	0.3	GO:0047631	ADP-ribose diphosphatase activity(GO:0047631)
0.1	0.2	GO:0097603	temperature-gated ion channel activity(GO:0097603)
0.1	0.2	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.1	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	0.0	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.2	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.0	GO:0016509	long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
0.0	0.2	GO:0017162	aryl hydrocarbon receptor binding(GO:0017162)
0.0	0.2	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0035651	AP-3 adaptor complex binding(GO:0035651)
0.0	0.1	GO:0035615	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.1	GO:0017153	sodium:dicarboxylate symporter activity(GO:0017153)
0.0	0.1	GO:0004104	cholinesterase activity(GO:0004104)
0.0	0.2	GO:0004862	cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.0	0.1	GO:0015526	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:0047751	3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) cholestenone 5-alpha-reductase activity(GO:0047751)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.2	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.3	GO:0038187	signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.0	0.1	GO:0050051	leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.0	0.1	GO:0008158	hedgehog receptor activity(GO:0008158)
0.0	0.1	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.1	GO:0015232	heme transporter activity(GO:0015232)
0.0	0.1	GO:0016721	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.1	GO:0071535	RING-like zinc finger domain binding(GO:0071535)
0.0	0.1	GO:0009041	uridylate kinase activity(GO:0009041)
0.0	0.4	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.1	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.0	0.2	GO:0008097	5S rRNA binding(GO:0008097)
0.0	0.1	GO:0004605	phosphatidate cytidylyltransferase activity(GO:0004605)
0.0	0.3	GO:0008191	metalloendopeptidase inhibitor activity(GO:0008191)
0.0	0.1	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.1	GO:0050309	glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0	0.1	GO:0004030	aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.0	0.1	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.0	0.1	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.0	GO:0016726	xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.0	0.1	GO:0032422	purine-rich negative regulatory element binding(GO:0032422)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.2	GO:0017166	vinculin binding(GO:0017166)
0.0	0.1	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.0	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0030984	kininogen binding(GO:0030984)
0.0	0.1	GO:0004174	electron-transferring-flavoprotein dehydrogenase activity(GO:0004174) oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor(GO:0016649)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.1	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0047499	calcium-independent phospholipase A2 activity(GO:0047499)
0.0	0.1	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0	0.1	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.2	GO:0001013	RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0	0.0	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	0.0	GO:0004731	purine-nucleoside phosphorylase activity(GO:0004731)
0.0	0.1	GO:0098518	polynucleotide phosphatase activity(GO:0098518)
0.0	0.1	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.2	GO:1900750	glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0	0.0	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.1	GO:1904264	ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0	0.0	GO:0071209	U7 snRNA binding(GO:0071209)
0.0	0.0	GO:0032767	copper-dependent protein binding(GO:0032767)
0.0	0.1	GO:0003945	N-acetyllactosamine synthase activity(GO:0003945)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.0	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.1	GO:0004457	lactate dehydrogenase activity(GO:0004457)
0.0	0.1	GO:0070181	small ribosomal subunit rRNA binding(GO:0070181)
0.0	0.0	GO:0015216	adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	0.0	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0035197	siRNA binding(GO:0035197)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.0	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.1	GO:0018585	fluorene oxygenase activity(GO:0018585)
0.0	0.1	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.0	0.0	GO:0060230	lipoprotein lipase activator activity(GO:0060230)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0019763	immunoglobulin receptor activity(GO:0019763)
0.0	0.0	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.0	0.2	GO:0016918	retinal binding(GO:0016918)
0.0	0.1	GO:0030942	endoplasmic reticulum signal peptide binding(GO:0030942)
0.0	0.1	GO:0004652	polynucleotide adenylyltransferase activity(GO:0004652)
0.0	0.0	GO:0004661	protein geranylgeranyltransferase activity(GO:0004661)
0.0	0.1	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0016803	ether hydrolase activity(GO:0016803)
0.0	0.0	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.0	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0016505	peptidase activator activity involved in apoptotic process(GO:0016505)
0.0	0.0	GO:0004126	cytidine deaminase activity(GO:0004126)
0.0	0.0	GO:0015252	hydrogen ion channel activity(GO:0015252)
0.0	0.0	GO:0004046	aminoacylase activity(GO:0004046)
0.0	0.0	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0	0.1	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	0.0	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.0	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0	0.2	GO:0030215	semaphorin receptor binding(GO:0030215)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.0	GO:0034618	arginine binding(GO:0034618)
0.0	0.1	GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	ST STAT3 PATHWAY	STAT3 Pathway
0.0	PID HIV NEF PATHWAY	HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.1	PID FOXO PATHWAY	FoxO family signaling
0.5	ST PHOSPHOINOSITIDE 3 KINASE PATHWAY	PI3K Pathway
0.0	PID S1P S1P1 PATHWAY	S1P1 pathway
0.0	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.1	ST INTERLEUKIN 4 PATHWAY	Interleukin 4 (IL-4) Pathway
0.3	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
0.0	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.1	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
0.0	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling
0.3	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.1	PID IL5 PATHWAY	IL5-mediated signaling events
0.0	PID TRAIL PATHWAY	TRAIL signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.0	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	0.1	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.0	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	0.2	REACTOME GAP JUNCTION DEGRADATION	Genes involved in Gap junction degradation
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.3	REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION	Genes involved in Pre-NOTCH Transcription and Translation
0.0	0.2	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.2	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.1	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.1	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.1	REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS	Genes involved in Membrane binding and targetting of GAG proteins
0.0	0.1	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.2	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
0.0	0.2	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.2	REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA	Genes involved in Circadian Repression of Expression by REV-ERBA
0.0	0.1	REACTOME RESOLUTION OF AP SITES VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the single-nucleotide replacement pathway