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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Nkx1-1_Nkx1-2

Z-value: 0.90

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Transcription factors associated with Nkx1-1_Nkx1-2

Gene Symbol	Gene ID	Gene Info
Nkx1-1 Ensembl NCBI MGI UniProt	ENSMUSG00000029112.5	Nkx1-1
Nkx1-2 Ensembl NCBI MGI UniProt	ENSMUSG00000048528.7	Nkx1-2

Activity of the Nkx1-1_Nkx1-2 motif across conditions

Conditions sorted by the z-value of the Nkx1-1_Nkx1-2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr6_112530748_112531068	0.79	Gm27944	predicted gene, 27944	17461	0.15
chr13_80895235_80895839	0.59	Arrdc3	arrestin domain containing 3	5019	0.18
chr5_138080510_138080792	0.56	Zkscan1	zinc finger with KRAB and SCAN domains 1	4433	0.1
chr7_139559759_139559933	0.52	Nkx6-2	NK6 homeobox 2	22944	0.17
chr3_105798169_105798320	0.49	Rap1a	RAS-related protein 1a	3041	0.15
chr19_43971247_43971535	0.45	Cpn1	carboxypeptidase N, polypeptide 1	2698	0.21
chr4_150598739_150598957	0.43	Rere	arginine glutamic acid dipeptide (RE) repeats	16567	0.18
chr16_31998270_31998421	0.42	Senp5	SUMO/sentrin specific peptidase 5	4818	0.09
chr7_26087500_26087684	0.41	Gm29920	predicted gene, 29920	12724	0.13
chr11_30774536_30774692	0.40	Psme4	proteasome (prosome, macropain) activator subunit 4	2293	0.25
chr7_39959522_39959690	0.38	Gm44992	predicted gene 44992	18468	0.21
chr5_114553263_114553436	0.37	Gm13790	predicted gene 13790	2060	0.28
chr13_58058115_58058280	0.36	Mir874	microRNA 874	34997	0.13
chr13_60267432_60267612	0.35	Gm24999	predicted gene, 24999	26150	0.16
chr3_97337526_97337699	0.33	Bcl9	B cell CLL/lymphoma 9	39695	0.14
chr4_148040579_148040753	0.32	Mthfr	methylenetetrahydrofolate reductase	144	0.9
chr11_108936283_108936686	0.32	Axin2	axin 2	2390	0.3
chr17_54678232_54678387	0.31	Gm26291	predicted gene, 26291	26373	0.25
chr1_89898377_89898561	0.31	Gbx2	gastrulation brain homeobox 2	30716	0.16
chr1_24612181_24612351	0.31	Gm28439	predicted gene 28439	144	0.72
chr2_75202592_75202875	0.31	Gm13653	predicted gene 13653	10456	0.15
chr4_153224874_153225025	0.30	Gm13174	predicted gene 13174	6773	0.3
chr6_50981986_50982138	0.30	Gm44402	predicted gene, 44402	14794	0.23
chr3_10149901_10150052	0.30	Pmp2	peripheral myelin protein 2	33953	0.1
chr6_28896411_28896583	0.29	Snd1	staphylococcal nuclease and tudor domain containing 1	16454	0.2
chr3_28706532_28706683	0.29	Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	8590	0.17
chr6_121878156_121878361	0.28	Mug1	murinoglobulin 1	7319	0.2
chr12_59160932_59161116	0.27	Mia2	MIA SH3 domain ER export factor 2	1866	0.28
chr10_123843693_123843994	0.26	Gm18510	predicted gene, 18510	48055	0.2
chr8_71699244_71699423	0.26	B3gnt3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	2456	0.13
chr11_106013602_106013764	0.26	Kcnh6	potassium voltage-gated channel, subfamily H (eag-related), member 6	90	0.94
chr6_97871999_97872401	0.26	Gm15531	predicted gene 15531	18339	0.23
chr11_96551158_96551309	0.26	Skap1	src family associated phosphoprotein 1	61372	0.09
chr9_112123334_112123526	0.25	Mir128-2	microRNA 128-2	4719	0.29
chr9_83099037_83099215	0.25	Gm38398	predicted gene, 38398	902	0.5
chr14_20177622_20177781	0.25	Kcnk5	potassium channel, subfamily K, member 5	4108	0.16
chr18_46722381_46722727	0.25	Cdo1	cysteine dioxygenase 1, cytosolic	5475	0.14
chr1_66862471_66862695	0.25	Acadl	acyl-Coenzyme A dehydrogenase, long-chain	694	0.5
chr4_32507009_32507324	0.24	Bach2	BTB and CNC homology, basic leucine zipper transcription factor 2	5661	0.25
chr17_7284590_7284752	0.24	Rps6ka2	ribosomal protein S6 kinase, polypeptide 2	24035	0.14
chr8_41052995_41053172	0.24	Gm16193	predicted gene 16193	27	0.96
chr4_117190012_117190473	0.24	Gm25099	predicted gene, 25099	300	0.73
chr6_112531173_112531324	0.23	Gm27944	predicted gene, 27944	17801	0.15
chr1_21131249_21131442	0.23	Gm2693	predicted gene 2693	47643	0.1
chr4_103934685_103934997	0.23	Gm12719	predicted gene 12719	4700	0.27
chr2_29443856_29444159	0.23	Gm24976	predicted gene, 24976	15187	0.16
chr2_119046481_119046794	0.23	Knl1	kinetochore scaffold 1	482	0.71
chr11_111605518_111605669	0.23	Gm11676	predicted gene 11676	7713	0.32
chr11_20543948_20544116	0.23	Sertad2	SERTA domain containing 2	698	0.73
chr2_146487304_146487455	0.23	Ralgapa2	Ral GTPase activating protein, alpha subunit 2 (catalytic)	24520	0.22
chr10_25595963_25596295	0.23	Gm36908	predicted gene, 36908	25434	0.15
chr5_89416345_89416742	0.23	Gc	vitamin D binding protein	19085	0.24
chr15_11380333_11380500	0.23	Tars	threonyl-tRNA synthetase	6929	0.25
chr1_84186097_84186268	0.22	Gm18304	predicted gene, 18304	17994	0.2
chr2_169724307_169724473	0.22	Tshz2	teashirt zinc finger family member 2	90714	0.08
chr12_5668476_5668791	0.22	Gm48599	predicted gene, 48599	77101	0.1
chr3_85551336_85551504	0.22	Gm42812	predicted gene 42812	1969	0.31
chr14_21071028_21071191	0.22	Adk	adenosine kinase	5043	0.23
chr3_85831893_85832058	0.21	Fam160a1	family with sequence similarity 160, member A1	14684	0.15
chr11_23954708_23954885	0.21	Gm12062	predicted gene 12062	25942	0.16
chr14_114090168_114090331	0.21	Gm18369	predicted gene, 18369	82194	0.11
chr14_64865582_64865960	0.21	Gm37183	predicted gene, 37183	26512	0.14
chr6_99210315_99210483	0.21	Foxp1	forkhead box P1	37937	0.21
chr18_64346648_64346799	0.21	Onecut2	one cut domain, family member 2	6703	0.18
chr3_144279874_144280028	0.21	Gm43446	predicted gene 43446	3860	0.25
chr1_147365933_147366089	0.20	Gm9931	predicted gene 9931	84069	0.1
chr5_145881335_145881631	0.20	Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	1519	0.36
chr2_34049474_34049625	0.20	C230014O12Rik	RIKEN cDNA C230014O12 gene	58180	0.11
chr1_36469911_36470078	0.20	Cnnm4	cyclin M4	1626	0.22
chr12_83087732_83087912	0.20	Gm29530	predicted gene 29530	11052	0.17
chr5_51511759_51511910	0.20	Gm43605	predicted gene 43605	2459	0.24
chr8_77961865_77962061	0.20	Gm29895	predicted gene, 29895	82047	0.09
chr5_135782110_135782261	0.20	Mdh2	malate dehydrogenase 2, NAD (mitochondrial)	3463	0.13
chr4_48152901_48153059	0.20	Stx17	syntaxin 17	28045	0.17
chr7_14430420_14431121	0.20	Sult2a8	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8	5677	0.17
chr8_125390183_125390334	0.20	Sipa1l2	signal-induced proliferation-associated 1 like 2	102452	0.07
chr16_31282098_31282249	0.20	Ppp1r2	protein phosphatase 1, regulatory inhibitor subunit 2	6896	0.11
chr2_64915505_64915665	0.20	Grb14	growth factor receptor bound protein 14	566	0.84
chr8_93959067_93959388	0.20	Gnao1	guanine nucleotide binding protein, alpha O	3617	0.19
chr9_30613779_30614132	0.20	Gm47716	predicted gene, 47716	18632	0.24
chr11_95724615_95724802	0.20	Zfp652	zinc finger protein 652	11697	0.12
chr10_7265928_7266272	0.20	Cnksr3	Cnksr family member 3	53863	0.15
chr11_98339208_98339359	0.20	Ppp1r1b	protein phosphatase 1, regulatory inhibitor subunit 1B	9121	0.09
chr11_100330372_100330542	0.19	Gast	gastrin	3950	0.09
chr1_72226394_72226550	0.19	Gm25360	predicted gene, 25360	232	0.89
chr15_77208076_77208227	0.19	Rbfox2	RNA binding protein, fox-1 homolog (C. elegans) 2	4715	0.18
chr12_102302828_102303218	0.19	Rin3	Ras and Rab interactor 3	19382	0.2
chr13_98594899_98595134	0.19	Gm4815	predicted gene 4815	18485	0.12
chr13_75722257_75722538	0.19	Gm48302	predicted gene, 48302	4882	0.15
chr3_27431035_27431235	0.19	Ghsr	growth hormone secretagogue receptor	59784	0.12
chr11_54355292_54355454	0.19	Gm12224	predicted gene 12224	1894	0.24
chr15_89471642_89471822	0.19	Arsa	arylsulfatase A	2539	0.13
chr7_84664728_84664917	0.19	Zfand6	zinc finger, AN1-type domain 6	14529	0.17
chr7_122533976_122534175	0.18	Gm14389	predicted gene 14389	49655	0.11
chr18_44633864_44634028	0.18	A930012L18Rik	RIKEN cDNA A930012L18 gene	27719	0.19
chr11_3983568_3983719	0.18	Gal3st1	galactose-3-O-sulfotransferase 1	7	0.95
chr1_178325132_178325283	0.18	Hnrnpu	heterogeneous nuclear ribonucleoprotein U	1036	0.37
chr11_63791140_63791492	0.18	Gm12288	predicted gene 12288	26984	0.21
chr5_117125186_117125352	0.18	Taok3	TAO kinase 3	1032	0.43
chr9_90136592_90136799	0.18	Tmem41b-ps	transmembrane protein 41B, pseudogene	17758	0.13
chr1_140018825_140019186	0.18	Gm26048	predicted gene, 26048	15180	0.15
chr6_112531381_112531532	0.18	Gm27944	predicted gene, 27944	18009	0.15
chr10_51553900_51554061	0.18	Gm48787	predicted gene, 48787	2533	0.16
chr7_140776294_140776445	0.18	Gm29799	predicted gene, 29799	8146	0.09
chr4_63738674_63738850	0.18	Tnfsf15	tumor necrosis factor (ligand) superfamily, member 15	6351	0.22
chr15_83471603_83471756	0.17	Pacsin2	protein kinase C and casein kinase substrate in neurons 2	7073	0.15
chr2_14099979_14100130	0.17	Stam	signal transducing adaptor molecule (SH3 domain and ITAM motif) 1	25627	0.12
chr18_10461260_10461439	0.17	Greb1l	growth regulation by estrogen in breast cancer-like	3124	0.25
chr2_178711802_178711999	0.17	Cdh26	cadherin-like 26	251270	0.02
chr2_167358690_167358858	0.17	B4galt5	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5	9591	0.19
chr5_76043835_76044206	0.17	Gm32780	predicted gene, 32780	922	0.54
chr15_53316381_53316532	0.17	Ext1	exostosin glycosyltransferase 1	29203	0.23
chr18_46553461_46553763	0.17	Ticam2	toll-like receptor adaptor molecule 2	20921	0.12
chr8_48553802_48554548	0.17	Tenm3	teneurin transmembrane protein 3	1138	0.64
chr12_33285610_33285770	0.17	Atxn7l1	ataxin 7-like 1	16825	0.2
chr18_54868802_54868964	0.17	Gm50366	predicted gene, 50366	783	0.63
chr6_121847052_121847216	0.17	Mug1	murinoglobulin 1	6030	0.23
chr5_87124253_87124404	0.17	Gm42795	predicted gene 42795	9719	0.12
chr19_57611799_57612005	0.17	Atrnl1	attractin like 1	868	0.62
chr2_160865636_160865792	0.17	Zhx3	zinc fingers and homeoboxes 3	6083	0.14
chr1_58203680_58204225	0.17	Aox4	aldehyde oxidase 4	6445	0.19
chr17_5798546_5798723	0.17	3300005D01Rik	RIKEN cDNA 3300005D01 gene	23	0.97
chr18_9811565_9811748	0.17	Gm50079	predicted gene, 50079	7128	0.15
chr16_29988549_29988737	0.17	Gm1968	predicted gene 1968	9459	0.16
chr4_105181181_105181508	0.17	Plpp3	phospholipid phosphatase 3	23997	0.24
chr13_85126680_85126842	0.17	Gm4076	predicted gene 4076	753	0.65
chr17_88614606_88614762	0.16	Gm9406	predicted gene 9406	6140	0.17
chr16_55810073_55810224	0.16	Nfkbiz	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta	8367	0.18
chr17_49205213_49205366	0.16	Gm9586	predicted gene 9586	39531	0.16
chr13_80896624_80897028	0.16	Arrdc3	arrestin domain containing 3	6308	0.17
chr9_115401508_115401659	0.16	Gm9487	predicted gene 9487	3566	0.16
chr19_38356216_38356572	0.16	Gm50150	predicted gene, 50150	13780	0.14
chr16_24394028_24394581	0.16	Lpp	LIM domain containing preferred translocation partner in lipoma	566	0.73
chr11_53420114_53420567	0.16	Leap2	liver-expressed antimicrobial peptide 2	2830	0.12
chr5_67215059_67215221	0.16	Tmem33	transmembrane protein 33	45425	0.12
chr16_76349002_76349359	0.16	Nrip1	nuclear receptor interacting protein 1	23857	0.18
chr1_60862632_60862783	0.16	Gm38137	predicted gene, 38137	17631	0.12
chr4_53104702_53105001	0.16	Abca1	ATP-binding cassette, sub-family A (ABC1), member 1	55044	0.11
chr1_190928195_190928363	0.16	Angel2	angel homolog 2	213	0.92
chrX_16816054_16816274	0.16	Maob	monoamine oxidase B	1111	0.65
chrX_75129625_75129782	0.16	Mpp1	membrane protein, palmitoylated	1141	0.32
chr18_20654349_20654505	0.16	Gm16090	predicted gene 16090	10833	0.17
chr12_17742392_17742683	0.16	Hpcal1	hippocalcin-like 1	14311	0.22
chr9_105878487_105878719	0.16	Col6a5	collagen, type VI, alpha 5	3203	0.27
chr13_112237981_112238162	0.15	Gm37427	predicted gene, 37427	18878	0.17
chr7_127666140_127666314	0.15	Gm44760	predicted gene 44760	7993	0.08
chr19_26600149_26600340	0.15	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	4806	0.21
chr3_85821665_85821854	0.15	Fam160a1	family with sequence similarity 160, member A1	4468	0.2
chr6_36281020_36281243	0.15	9330158H04Rik	RIKEN cDNA 9330158H04 gene	6775	0.29
chr1_92180367_92180696	0.15	Hdac4	histone deacetylase 4	190	0.96
chr10_82220492_82220673	0.15	Zfp938	zinc finger protein 938	20691	0.13
chr3_121279413_121279568	0.15	Gm30517	predicted gene, 30517	1966	0.25
chr18_37765813_37765974	0.15	Pcdhga12	protocadherin gamma subfamily A, 12	120	0.85
chr14_28505648_28505933	0.15	Wnt5a	wingless-type MMTV integration site family, member 5A	110	0.97
chr13_113535001_113535152	0.15	4921509O07Rik	RIKEN cDNA 4921509O07 gene	32232	0.12
chr5_72404662_72404813	0.15	Gm19560	predicted gene, 19560	4707	0.18
chr7_133052922_133053103	0.15	Ctbp2	C-terminal binding protein 2	22896	0.16
chr10_75522174_75522329	0.15	Snrpd3	small nuclear ribonucleoprotein D3	4208	0.13
chr1_43445213_43445518	0.15	Nck2	non-catalytic region of tyrosine kinase adaptor protein 2	386	0.87
chr1_188853017_188853420	0.15	Gm25269	predicted gene, 25269	92742	0.08
chr11_114375981_114376365	0.15	Gm11692	predicted gene 11692	19044	0.21
chr4_134922832_134923008	0.15	Rsrp1	arginine/serine rich protein 1	672	0.64
chr8_120230897_120231102	0.15	Gse1	genetic suppressor element 1, coiled-coil protein	2543	0.23
chr8_22510204_22510364	0.15	Slc20a2	solute carrier family 20, member 2	4058	0.18
chr17_29094634_29094798	0.15	1700023B13Rik	RIKEN cDNA 1700023B13 gene	255	0.77
chr1_187764201_187764362	0.15	AC121143.1	NADH dehydrogenase 2, mitochondrial (mt-Nd2) pseudogene	51476	0.16
chr12_84165735_84165922	0.15	Elmsan1	ELM2 and Myb/SANT-like domain containing 1	5690	0.11
chr2_163541251_163541470	0.15	Hnf4aos	hepatic nuclear factor 4 alpha, opposite strand	332	0.83
chr12_75862976_75863134	0.14	Syne2	spectrin repeat containing, nuclear envelope 2	10325	0.24
chr11_95869540_95869834	0.14	Gm11534	predicted gene 11534	533	0.62
chr5_93323705_93323875	0.14	Ccng2	cyclin G2	55082	0.1
chr3_145621208_145621546	0.14	Znhit6	zinc finger, HIT type 6	25509	0.15
chr1_4820222_4820413	0.14	Lypla1	lysophospholipase 1	12080	0.11
chr5_63897626_63897962	0.14	0610040J01Rik	RIKEN cDNA 0610040J01 gene	20318	0.15
chr5_65599782_65600155	0.14	Ube2k	ubiquitin-conjugating enzyme E2K	8372	0.1
chr10_116221046_116221335	0.14	Ptprr	protein tyrosine phosphatase, receptor type, R	24794	0.18
chr7_25916218_25916383	0.14	Cyp2b10	cytochrome P450, family 2, subfamily b, polypeptide 10	466	0.72
chr16_20371861_20372035	0.14	Abcc5	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	4694	0.18
chr18_46712849_46713058	0.14	Cdo1	cysteine dioxygenase 1, cytosolic	15076	0.12
chr1_165760792_165760967	0.14	Creg1	cellular repressor of E1A-stimulated genes 1	2867	0.13
chr6_121890040_121890777	0.14	Mug1	murinoglobulin 1	4831	0.21
chr4_81841873_81842024	0.14	n-R5s187	nuclear encoded rRNA 5S 187	76565	0.1
chr2_69911096_69911271	0.14	Ubr3	ubiquitin protein ligase E3 component n-recognin 3	13880	0.13
chr11_43217118_43217287	0.14	Gm12144	predicted gene 12144	15062	0.19
chr6_50986659_50986810	0.14	Gm44402	predicted gene, 44402	19466	0.22
chr10_115298774_115299175	0.14	Rab21	RAB21, member RAS oncogene family	16617	0.14
chr3_135842259_135842432	0.14	4933401H06Rik	RIKEN cDNA 4933401H06 gene	2076	0.25
chr12_78215748_78215899	0.14	Gphn	gephyrin	10556	0.14
chr7_123124873_123125354	0.14	Tnrc6a	trinucleotide repeat containing 6a	857	0.66
chr3_86560323_86560494	0.14	Mab21l2	mab-21-like 2	11779	0.21
chr13_37665370_37665760	0.14	AI463229	expressed sequence AI463229	977	0.42
chr8_119912901_119913087	0.14	Usp10	ubiquitin specific peptidase 10	2137	0.24
chr2_118318601_118318758	0.14	1700054M17Rik	RIKEN cDNA 1700054M17 gene	13765	0.13
chr5_112908382_112908548	0.14	Myo18b	myosin XVIIIb	12103	0.19
chr11_72737626_72737777	0.14	Ankfy1	ankyrin repeat and FYVE domain containing 1	22215	0.16
chr11_107467010_107467274	0.13	Pitpnc1	phosphatidylinositol transfer protein, cytoplasmic 1	3557	0.15
chr9_121928936_121929087	0.13	Gm47115	predicted gene, 47115	5069	0.09
chr15_75803070_75803233	0.13	Zc3h3	zinc finger CCCH type containing 3	9708	0.12
chr10_63060758_63060924	0.13	Pbld1	phenazine biosynthesis-like protein domain containing 1	112	0.93
chr13_46466566_46466717	0.13	Cap2	CAP, adenylate cyclase-associated protein, 2 (yeast)	35207	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx1-1_Nkx1-2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0070827	chromatin maintenance(GO:0070827)
0.1	0.2	GO:0048022	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.1	0.2	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.1	0.2	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0090365	regulation of mRNA modification(GO:0090365)
0.0	0.1	GO:2000836	androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
0.0	0.1	GO:1903898	negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0	0.1	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0010912	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.1	GO:2000054	negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0	0.1	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.2	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.2	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0061052	negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0	0.1	GO:0014894	response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.1	GO:2000019	negative regulation of male gonad development(GO:2000019)
0.0	0.1	GO:0001992	regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0	0.2	GO:0045409	negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.1	GO:0002669	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0	0.1	GO:0006651	diacylglycerol biosynthetic process(GO:0006651)
0.0	0.1	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.1	GO:2000566	positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0	0.1	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.0	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.2	GO:2001214	positive regulation of vasculogenesis(GO:2001214)
0.0	0.1	GO:0009115	xanthine catabolic process(GO:0009115)
0.0	0.1	GO:0014063	negative regulation of serotonin secretion(GO:0014063)
0.0	0.1	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.1	GO:0051661	maintenance of centrosome location(GO:0051661)
0.0	0.1	GO:0035553	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:2000097	regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.0	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.1	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.0	0.1	GO:0010520	regulation of reciprocal meiotic recombination(GO:0010520)
0.0	0.1	GO:1901142	insulin metabolic process(GO:1901142)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.1	GO:0006621	protein retention in ER lumen(GO:0006621)
0.0	0.1	GO:0009093	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0042738	exogenous drug catabolic process(GO:0042738)
0.0	0.0	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0006370	7-methylguanosine mRNA capping(GO:0006370)
0.0	0.1	GO:0014022	neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0	0.1	GO:0021586	pons maturation(GO:0021586)
0.0	0.1	GO:0046813	receptor-mediated virion attachment to host cell(GO:0046813)
0.0	0.1	GO:0021773	striatal medium spiny neuron differentiation(GO:0021773)
0.0	0.1	GO:2000507	positive regulation of energy homeostasis(GO:2000507)
0.0	0.1	GO:0086073	bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0	0.0	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.0	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.2	GO:0035278	miRNA mediated inhibition of translation(GO:0035278)
0.0	0.0	GO:0060448	dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0036135	Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0	0.0	GO:2000564	regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.0	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.0	GO:0007529	establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.0	0.2	GO:0070935	3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0	0.0	GO:0003331	regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0	0.0	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0	0.1	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.1	GO:0010216	maintenance of DNA methylation(GO:0010216)
0.0	0.1	GO:0042663	regulation of endodermal cell fate specification(GO:0042663)
0.0	0.0	GO:0042322	negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
0.0	0.0	GO:1990791	dorsal root ganglion development(GO:1990791)
0.0	0.0	GO:0097503	sialylation(GO:0097503)
0.0	0.1	GO:0007262	STAT protein import into nucleus(GO:0007262)
0.0	0.0	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.1	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.0	GO:0019086	late viral transcription(GO:0019086)
0.0	0.1	GO:0010529	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0	0.0	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.0	GO:0060137	maternal process involved in parturition(GO:0060137)
0.0	0.0	GO:0002018	renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0	0.1	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.0	0.0	GO:0070294	renal sodium ion absorption(GO:0070294)
0.0	0.2	GO:0060390	regulation of SMAD protein import into nucleus(GO:0060390)
0.0	0.0	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.1	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.0	GO:0060318	definitive erythrocyte differentiation(GO:0060318)
0.0	0.1	GO:0019244	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0	0.0	GO:0048294	negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0	0.0	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0	0.1	GO:0033617	mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0	0.0	GO:0031587	positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0	0.0	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.0	GO:0071462	cellular response to water stimulus(GO:0071462)
0.0	0.0	GO:0051964	negative regulation of synapse assembly(GO:0051964)
0.0	0.0	GO:0043622	cortical microtubule organization(GO:0043622)
0.0	0.1	GO:0034374	low-density lipoprotein particle remodeling(GO:0034374)
0.0	0.1	GO:0060613	fat pad development(GO:0060613)
0.0	0.0	GO:1902809	regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0	0.0	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.0	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0	0.0	GO:0097368	establishment of Sertoli cell barrier(GO:0097368)
0.0	0.0	GO:0072367	regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0	0.0	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0006591	ornithine metabolic process(GO:0006591)
0.0	0.1	GO:0098719	sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0	0.0	GO:0006269	DNA replication, synthesis of RNA primer(GO:0006269)
0.0	0.0	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.0	GO:0035523	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.0	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0	0.0	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0	0.1	GO:0061684	chaperone-mediated autophagy(GO:0061684)
0.0	0.0	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0014010	Schwann cell proliferation(GO:0014010)
0.0	0.1	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0	0.0	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.1	GO:0046501	protoporphyrinogen IX metabolic process(GO:0046501)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0000836	ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.1	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.1	GO:1990111	spermatoproteasome complex(GO:1990111)
0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.2	GO:0042587	glycogen granule(GO:0042587)
0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.1	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0	GO:0016533	cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0	GO:0097504	Gemini of coiled bodies(GO:0097504)
0.0	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	GO:0031523	Myb complex(GO:0031523)
0.1	GO:0097433	dense body(GO:0097433)
0.0	GO:0043511	inhibin complex(GO:0043511)
0.2	GO:0005640	nuclear outer membrane(GO:0005640)
0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	GO:0070110	ciliary neurotrophic factor receptor complex(GO:0070110)
0.0	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	GO:1990246	uniplex complex(GO:1990246)
0.0	GO:0097443	sorting endosome(GO:0097443)
0.0	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.2	GO:0071565	nBAF complex(GO:0071565)
0.0	GO:0005658	alpha DNA polymerase:primase complex(GO:0005658)
0.0	GO:0042583	chromaffin granule(GO:0042583)
0.0	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	GO:0043202	lysosomal lumen(GO:0043202)
0.0	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular function category:

Total log-likelihood	Term	Description
0.1	GO:0015205	purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.1	GO:0004144	diacylglycerol O-acyltransferase activity(GO:0004144)
0.1	GO:0004031	aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.1	GO:0000340	RNA 7-methylguanosine cap binding(GO:0000340)
0.1	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.1	GO:0004645	phosphorylase activity(GO:0004645)
0.0	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.1	GO:0042731	PH domain binding(GO:0042731)
0.1	GO:0034819	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.1	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.1	GO:0019776	Atg8 ligase activity(GO:0019776)
0.1	GO:0005000	vasopressin receptor activity(GO:0005000)
0.2	GO:0050649	testosterone 6-beta-hydroxylase activity(GO:0050649)
0.1	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.1	GO:0004466	long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.1	GO:0008131	primary amine oxidase activity(GO:0008131)
0.2	GO:0070034	telomerase RNA binding(GO:0070034)
0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.1	GO:0033300	dehydroascorbic acid transporter activity(GO:0033300)
0.3	GO:0016646	oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.1	GO:0032557	pyrimidine ribonucleotide binding(GO:0032557)
0.0	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.0	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.1	GO:0042301	phosphate ion binding(GO:0042301)
0.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.1	GO:1990254	keratin filament binding(GO:1990254)
0.1	GO:0004459	L-lactate dehydrogenase activity(GO:0004459)
0.0	GO:0003886	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.2	GO:0005242	inward rectifier potassium channel activity(GO:0005242)
0.0	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.1	GO:1904288	BAT3 complex binding(GO:1904288)
0.0	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.1	GO:0071253	connexin binding(GO:0071253)
0.1	GO:0016841	ammonia-lyase activity(GO:0016841)
0.0	GO:0008142	oxysterol binding(GO:0008142)
0.0	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	GO:0001884	pyrimidine nucleoside binding(GO:0001884)
0.1	GO:0034481	chondroitin sulfotransferase activity(GO:0034481)
0.1	GO:0015385	sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	GO:0017116	single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.1	GO:0043023	ribosomal large subunit binding(GO:0043023)
0.0	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0	GO:0043199	sulfate binding(GO:0043199)
0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1	GO:0016443	bidentate ribonuclease III activity(GO:0016443)
0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1	GO:0015198	oligopeptide transporter activity(GO:0015198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID LYSOPHOSPHOLIPID PATHWAY	LPA receptor mediated events
0.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.3	PID REELIN PATHWAY	Reelin signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.1	REACTOME ACTIVATION OF RAC	Genes involved in Activation of Rac
0.1	REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT	Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.1	REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION	Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication