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ENCSR904DTN: DNase-seq of mouse liver in constant darkness
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Results for Nkx1-1_Nkx1-2

Z-value: 0.90

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Transcription factors associated with Nkx1-1_Nkx1-2

Gene Symbol Gene ID Gene Info
Nkx1-1
ENSMUSG00000029112.5 NK1 homeobox 1
Nkx1-2
ENSMUSG00000048528.7 NK1 homeobox 2

Activity of the Nkx1-1_Nkx1-2 motif across conditions

Conditions sorted by the z-value of the Nkx1-1_Nkx1-2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE) Target Score Top associated gene Gene Info Distance of CRE to TSS CRE/Gene association probability
chr6_112530748_112531068 0.79 Gm27944
 predicted gene, 27944
 17461
 0.15
chr13_80895235_80895839 0.59 Arrdc3
 arrestin domain containing 3
 5019
 0.18
chr5_138080510_138080792 0.56 Zkscan1
 zinc finger with KRAB and SCAN domains 1
 4433
 0.1
chr7_139559759_139559933 0.52 Nkx6-2
 NK6 homeobox 2
 22944
 0.17
chr3_105798169_105798320 0.49 Rap1a
 RAS-related protein 1a
 3041
 0.15
chr19_43971247_43971535 0.45 Cpn1
 carboxypeptidase N, polypeptide 1
 2698
 0.21
chr4_150598739_150598957 0.43 Rere
 arginine glutamic acid dipeptide (RE) repeats
 16567
 0.18
chr16_31998270_31998421 0.42 Senp5
 SUMO/sentrin specific peptidase 5
 4818
 0.09
chr7_26087500_26087684 0.41 Gm29920
 predicted gene, 29920
 12724
 0.13
chr11_30774536_30774692 0.40 Psme4
 proteasome (prosome, macropain) activator subunit 4
 2293
 0.25
chr7_39959522_39959690 0.38 Gm44992
 predicted gene 44992
 18468
 0.21
chr5_114553263_114553436 0.37 Gm13790
 predicted gene 13790
 2060
 0.28
chr13_58058115_58058280 0.36 Mir874
 microRNA 874
 34997
 0.13
chr13_60267432_60267612 0.35 Gm24999
 predicted gene, 24999
 26150
 0.16
chr3_97337526_97337699 0.33 Bcl9
 B cell CLL/lymphoma 9
 39695
 0.14
chr4_148040579_148040753 0.32 Mthfr
 methylenetetrahydrofolate reductase
 144
 0.9
chr11_108936283_108936686 0.32 Axin2
 axin 2
 2390
 0.3
chr17_54678232_54678387 0.31 Gm26291
 predicted gene, 26291
 26373
 0.25
chr1_89898377_89898561 0.31 Gbx2
 gastrulation brain homeobox 2
 30716
 0.16
chr1_24612181_24612351 0.31 Gm28439
 predicted gene 28439
 144
 0.72
chr2_75202592_75202875 0.31 Gm13653
 predicted gene 13653
 10456
 0.15
chr4_153224874_153225025 0.30 Gm13174
 predicted gene 13174
 6773
 0.3
chr6_50981986_50982138 0.30 Gm44402
 predicted gene, 44402
 14794
 0.23
chr3_10149901_10150052 0.30 Pmp2
 peripheral myelin protein 2
 33953
 0.1
chr6_28896411_28896583 0.29 Snd1
 staphylococcal nuclease and tudor domain containing 1
 16454
 0.2
chr3_28706532_28706683 0.29 Slc2a2
 solute carrier family 2 (facilitated glucose transporter), member 2
 8590
 0.17
chr6_121878156_121878361 0.28 Mug1
 murinoglobulin 1
 7319
 0.2
chr12_59160932_59161116 0.27 Mia2
 MIA SH3 domain ER export factor 2
 1866
 0.28
chr10_123843693_123843994 0.26 Gm18510
 predicted gene, 18510
 48055
 0.2
chr8_71699244_71699423 0.26 B3gnt3
 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3
 2456
 0.13
chr11_106013602_106013764 0.26 Kcnh6
 potassium voltage-gated channel, subfamily H (eag-related), member 6
 90
 0.94
chr6_97871999_97872401 0.26 Gm15531
 predicted gene 15531
 18339
 0.23
chr11_96551158_96551309 0.26 Skap1
 src family associated phosphoprotein 1
 61372
 0.09
chr9_112123334_112123526 0.25 Mir128-2
 microRNA 128-2
 4719
 0.29
chr9_83099037_83099215 0.25 Gm38398
 predicted gene, 38398
 902
 0.5
chr14_20177622_20177781 0.25 Kcnk5
 potassium channel, subfamily K, member 5
 4108
 0.16
chr18_46722381_46722727 0.25 Cdo1
 cysteine dioxygenase 1, cytosolic
 5475
 0.14
chr1_66862471_66862695 0.25 Acadl
 acyl-Coenzyme A dehydrogenase, long-chain
 694
 0.5
chr4_32507009_32507324 0.24 Bach2
 BTB and CNC homology, basic leucine zipper transcription factor 2
 5661
 0.25
chr17_7284590_7284752 0.24 Rps6ka2
 ribosomal protein S6 kinase, polypeptide 2
 24035
 0.14
chr8_41052995_41053172 0.24 Gm16193
 predicted gene 16193
 27
 0.96
chr4_117190012_117190473 0.24 Gm25099
 predicted gene, 25099
 300
 0.73
chr6_112531173_112531324 0.23 Gm27944
 predicted gene, 27944
 17801
 0.15
chr1_21131249_21131442 0.23 Gm2693
 predicted gene 2693
 47643
 0.1
chr4_103934685_103934997 0.23 Gm12719
 predicted gene 12719
 4700
 0.27
chr2_29443856_29444159 0.23 Gm24976
 predicted gene, 24976
 15187
 0.16
chr2_119046481_119046794 0.23 Knl1
 kinetochore scaffold 1
 482
 0.71
chr11_111605518_111605669 0.23 Gm11676
 predicted gene 11676
 7713
 0.32
chr11_20543948_20544116 0.23 Sertad2
 SERTA domain containing 2
 698
 0.73
chr2_146487304_146487455 0.23 Ralgapa2
 Ral GTPase activating protein, alpha subunit 2 (catalytic)
 24520
 0.22
chr10_25595963_25596295 0.23 Gm36908
 predicted gene, 36908
 25434
 0.15
chr5_89416345_89416742 0.23 Gc
 vitamin D binding protein
 19085
 0.24
chr15_11380333_11380500 0.23 Tars
 threonyl-tRNA synthetase
 6929
 0.25
chr1_84186097_84186268 0.22 Gm18304
 predicted gene, 18304
 17994
 0.2
chr2_169724307_169724473 0.22 Tshz2
 teashirt zinc finger family member 2
 90714
 0.08
chr12_5668476_5668791 0.22 Gm48599
 predicted gene, 48599
 77101
 0.1
chr3_85551336_85551504 0.22 Gm42812
 predicted gene 42812
 1969
 0.31
chr14_21071028_21071191 0.22 Adk
 adenosine kinase
 5043
 0.23
chr3_85831893_85832058 0.21 Fam160a1
 family with sequence similarity 160, member A1
 14684
 0.15
chr11_23954708_23954885 0.21 Gm12062
 predicted gene 12062
 25942
 0.16
chr14_114090168_114090331 0.21 Gm18369
 predicted gene, 18369
 82194
 0.11
chr14_64865582_64865960 0.21 Gm37183
 predicted gene, 37183
 26512
 0.14
chr6_99210315_99210483 0.21 Foxp1
 forkhead box P1
 37937
 0.21
chr18_64346648_64346799 0.21 Onecut2
 one cut domain, family member 2
 6703
 0.18
chr3_144279874_144280028 0.21 Gm43446
 predicted gene 43446
 3860
 0.25
chr1_147365933_147366089 0.20 Gm9931
 predicted gene 9931
 84069
 0.1
chr5_145881335_145881631 0.20 Cyp3a11
 cytochrome P450, family 3, subfamily a, polypeptide 11
 1519
 0.36
chr2_34049474_34049625 0.20 C230014O12Rik
 RIKEN cDNA C230014O12 gene
 58180
 0.11
chr1_36469911_36470078 0.20 Cnnm4
 cyclin M4
 1626
 0.22
chr12_83087732_83087912 0.20 Gm29530
 predicted gene 29530
 11052
 0.17
chr5_51511759_51511910 0.20 Gm43605
 predicted gene 43605
 2459
 0.24
chr8_77961865_77962061 0.20 Gm29895
 predicted gene, 29895
 82047
 0.09
chr5_135782110_135782261 0.20 Mdh2
 malate dehydrogenase 2, NAD (mitochondrial)
 3463
 0.13
chr4_48152901_48153059 0.20 Stx17
 syntaxin 17
 28045
 0.17
chr7_14430420_14431121 0.20 Sult2a8
 sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8
 5677
 0.17
chr8_125390183_125390334 0.20 Sipa1l2
 signal-induced proliferation-associated 1 like 2
 102452
 0.07
chr16_31282098_31282249 0.20 Ppp1r2
 protein phosphatase 1, regulatory inhibitor subunit 2
 6896
 0.11
chr2_64915505_64915665 0.20 Grb14
 growth factor receptor bound protein 14
 566
 0.84
chr8_93959067_93959388 0.20 Gnao1
 guanine nucleotide binding protein, alpha O
 3617
 0.19
chr9_30613779_30614132 0.20 Gm47716
 predicted gene, 47716
 18632
 0.24
chr11_95724615_95724802 0.20 Zfp652
 zinc finger protein 652
 11697
 0.12
chr10_7265928_7266272 0.20 Cnksr3
 Cnksr family member 3
 53863
 0.15
chr11_98339208_98339359 0.20 Ppp1r1b
 protein phosphatase 1, regulatory inhibitor subunit 1B
 9121
 0.09
chr11_100330372_100330542 0.19 Gast
 gastrin
 3950
 0.09
chr1_72226394_72226550 0.19 Gm25360
 predicted gene, 25360
 232
 0.89
chr15_77208076_77208227 0.19 Rbfox2
 RNA binding protein, fox-1 homolog (C. elegans) 2
 4715
 0.18
chr12_102302828_102303218 0.19 Rin3
 Ras and Rab interactor 3
 19382
 0.2
chr13_98594899_98595134 0.19 Gm4815
 predicted gene 4815
 18485
 0.12
chr13_75722257_75722538 0.19 Gm48302
 predicted gene, 48302
 4882
 0.15
chr3_27431035_27431235 0.19 Ghsr
 growth hormone secretagogue receptor
 59784
 0.12
chr11_54355292_54355454 0.19 Gm12224
 predicted gene 12224
 1894
 0.24
chr15_89471642_89471822 0.19 Arsa
 arylsulfatase A
 2539
 0.13
chr7_84664728_84664917 0.19 Zfand6
 zinc finger, AN1-type domain 6
 14529
 0.17
chr7_122533976_122534175 0.18 Gm14389
 predicted gene 14389
 49655
 0.11
chr18_44633864_44634028 0.18 A930012L18Rik
 RIKEN cDNA A930012L18 gene
 27719
 0.19
chr11_3983568_3983719 0.18 Gal3st1
 galactose-3-O-sulfotransferase 1
 7
 0.95
chr1_178325132_178325283 0.18 Hnrnpu
 heterogeneous nuclear ribonucleoprotein U
 1036
 0.37
chr11_63791140_63791492 0.18 Gm12288
 predicted gene 12288
 26984
 0.21
chr5_117125186_117125352 0.18 Taok3
 TAO kinase 3
 1032
 0.43
chr9_90136592_90136799 0.18 Tmem41b-ps
 transmembrane protein 41B, pseudogene
 17758
 0.13
chr1_140018825_140019186 0.18 Gm26048
 predicted gene, 26048
 15180
 0.15
chr6_112531381_112531532 0.18 Gm27944
 predicted gene, 27944
 18009
 0.15
chr10_51553900_51554061 0.18 Gm48787
 predicted gene, 48787
 2533
 0.16
chr7_140776294_140776445 0.18 Gm29799
 predicted gene, 29799
 8146
 0.09
chr4_63738674_63738850 0.18 Tnfsf15
 tumor necrosis factor (ligand) superfamily, member 15
 6351
 0.22
chr15_83471603_83471756 0.17 Pacsin2
 protein kinase C and casein kinase substrate in neurons 2
 7073
 0.15
chr2_14099979_14100130 0.17 Stam
 signal transducing adaptor molecule (SH3 domain and ITAM motif) 1
 25627
 0.12
chr18_10461260_10461439 0.17 Greb1l
 growth regulation by estrogen in breast cancer-like
 3124
 0.25
chr2_178711802_178711999 0.17 Cdh26
 cadherin-like 26
 251270
 0.02
chr2_167358690_167358858 0.17 B4galt5
 UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 5
 9591
 0.19
chr5_76043835_76044206 0.17 Gm32780
 predicted gene, 32780
 922
 0.54
chr15_53316381_53316532 0.17 Ext1
 exostosin glycosyltransferase 1
 29203
 0.23
chr18_46553461_46553763 0.17 Ticam2
 toll-like receptor adaptor molecule 2
 20921
 0.12
chr8_48553802_48554548 0.17 Tenm3
 teneurin transmembrane protein 3
 1138
 0.64
chr12_33285610_33285770 0.17 Atxn7l1
 ataxin 7-like 1
 16825
 0.2
chr18_54868802_54868964 0.17 Gm50366
 predicted gene, 50366
 783
 0.63
chr6_121847052_121847216 0.17 Mug1
 murinoglobulin 1
 6030
 0.23
chr5_87124253_87124404 0.17 Gm42795
 predicted gene 42795
 9719
 0.12
chr19_57611799_57612005 0.17 Atrnl1
 attractin like 1
 868
 0.62
chr2_160865636_160865792 0.17 Zhx3
 zinc fingers and homeoboxes 3
 6083
 0.14
chr1_58203680_58204225 0.17 Aox4
 aldehyde oxidase 4
 6445
 0.19
chr17_5798546_5798723 0.17 3300005D01Rik
 RIKEN cDNA 3300005D01 gene
 23
 0.97
chr18_9811565_9811748 0.17 Gm50079
 predicted gene, 50079
 7128
 0.15
chr16_29988549_29988737 0.17 Gm1968
 predicted gene 1968
 9459
 0.16
chr4_105181181_105181508 0.17 Plpp3
 phospholipid phosphatase 3
 23997
 0.24
chr13_85126680_85126842 0.17 Gm4076
 predicted gene 4076
 753
 0.65
chr17_88614606_88614762 0.16 Gm9406
 predicted gene 9406
 6140
 0.17
chr16_55810073_55810224 0.16 Nfkbiz
 nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, zeta
 8367
 0.18
chr17_49205213_49205366 0.16 Gm9586
 predicted gene 9586
 39531
 0.16
chr13_80896624_80897028 0.16 Arrdc3
 arrestin domain containing 3
 6308
 0.17
chr9_115401508_115401659 0.16 Gm9487
 predicted gene 9487
 3566
 0.16
chr19_38356216_38356572 0.16 Gm50150
 predicted gene, 50150
 13780
 0.14
chr16_24394028_24394581 0.16 Lpp
 LIM domain containing preferred translocation partner in lipoma
 566
 0.73
chr11_53420114_53420567 0.16 Leap2
 liver-expressed antimicrobial peptide 2
 2830
 0.12
chr5_67215059_67215221 0.16 Tmem33
 transmembrane protein 33
 45425
 0.12
chr16_76349002_76349359 0.16 Nrip1
 nuclear receptor interacting protein 1
 23857
 0.18
chr1_60862632_60862783 0.16 Gm38137
 predicted gene, 38137
 17631
 0.12
chr4_53104702_53105001 0.16 Abca1
 ATP-binding cassette, sub-family A (ABC1), member 1
 55044
 0.11
chr1_190928195_190928363 0.16 Angel2
 angel homolog 2
 213
 0.92
chrX_16816054_16816274 0.16 Maob
 monoamine oxidase B
 1111
 0.65
chrX_75129625_75129782 0.16 Mpp1
 membrane protein, palmitoylated
 1141
 0.32
chr18_20654349_20654505 0.16 Gm16090
 predicted gene 16090
 10833
 0.17
chr12_17742392_17742683 0.16 Hpcal1
 hippocalcin-like 1
 14311
 0.22
chr9_105878487_105878719 0.16 Col6a5
 collagen, type VI, alpha 5
 3203
 0.27
chr13_112237981_112238162 0.15 Gm37427
 predicted gene, 37427
 18878
 0.17
chr7_127666140_127666314 0.15 Gm44760
 predicted gene 44760
 7993
 0.08
chr19_26600149_26600340 0.15 Smarca2
 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
 4806
 0.21
chr3_85821665_85821854 0.15 Fam160a1
 family with sequence similarity 160, member A1
 4468
 0.2
chr6_36281020_36281243 0.15 9330158H04Rik
 RIKEN cDNA 9330158H04 gene
 6775
 0.29
chr1_92180367_92180696 0.15 Hdac4
 histone deacetylase 4
 190
 0.96
chr10_82220492_82220673 0.15 Zfp938
 zinc finger protein 938
 20691
 0.13
chr3_121279413_121279568 0.15 Gm30517
 predicted gene, 30517
 1966
 0.25
chr18_37765813_37765974 0.15 Pcdhga12
 protocadherin gamma subfamily A, 12
 120
 0.85
chr14_28505648_28505933 0.15 Wnt5a
 wingless-type MMTV integration site family, member 5A
 110
 0.97
chr13_113535001_113535152 0.15 4921509O07Rik
 RIKEN cDNA 4921509O07 gene
 32232
 0.12
chr5_72404662_72404813 0.15 Gm19560
 predicted gene, 19560
 4707
 0.18
chr7_133052922_133053103 0.15 Ctbp2
 C-terminal binding protein 2
 22896
 0.16
chr10_75522174_75522329 0.15 Snrpd3
 small nuclear ribonucleoprotein D3
 4208
 0.13
chr1_43445213_43445518 0.15 Nck2
 non-catalytic region of tyrosine kinase adaptor protein 2
 386
 0.87
chr1_188853017_188853420 0.15 Gm25269
 predicted gene, 25269
 92742
 0.08
chr11_114375981_114376365 0.15 Gm11692
 predicted gene 11692
 19044
 0.21
chr4_134922832_134923008 0.15 Rsrp1
 arginine/serine rich protein 1
 672
 0.64
chr8_120230897_120231102 0.15 Gse1
 genetic suppressor element 1, coiled-coil protein
 2543
 0.23
chr8_22510204_22510364 0.15 Slc20a2
 solute carrier family 20, member 2
 4058
 0.18
chr17_29094634_29094798 0.15 1700023B13Rik
 RIKEN cDNA 1700023B13 gene
 255
 0.77
chr1_187764201_187764362 0.15 AC121143.1
 NADH dehydrogenase 2, mitochondrial (mt-Nd2) pseudogene
 51476
 0.16
chr12_84165735_84165922 0.15 Elmsan1
 ELM2 and Myb/SANT-like domain containing 1
 5690
 0.11
chr2_163541251_163541470 0.15 Hnf4aos
 hepatic nuclear factor 4 alpha, opposite strand
 332
 0.83
chr12_75862976_75863134 0.14 Syne2
 spectrin repeat containing, nuclear envelope 2
 10325
 0.24
chr11_95869540_95869834 0.14 Gm11534
 predicted gene 11534
 533
 0.62
chr5_93323705_93323875 0.14 Ccng2
 cyclin G2
 55082
 0.1
chr3_145621208_145621546 0.14 Znhit6
 zinc finger, HIT type 6
 25509
 0.15
chr1_4820222_4820413 0.14 Lypla1
 lysophospholipase 1
 12080
 0.11
chr5_63897626_63897962 0.14 0610040J01Rik
 RIKEN cDNA 0610040J01 gene
 20318
 0.15
chr5_65599782_65600155 0.14 Ube2k
 ubiquitin-conjugating enzyme E2K
 8372
 0.1
chr10_116221046_116221335 0.14 Ptprr
 protein tyrosine phosphatase, receptor type, R
 24794
 0.18
chr7_25916218_25916383 0.14 Cyp2b10
 cytochrome P450, family 2, subfamily b, polypeptide 10
 466
 0.72
chr16_20371861_20372035 0.14 Abcc5
 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
 4694
 0.18
chr18_46712849_46713058 0.14 Cdo1
 cysteine dioxygenase 1, cytosolic
 15076
 0.12
chr1_165760792_165760967 0.14 Creg1
 cellular repressor of E1A-stimulated genes 1
 2867
 0.13
chr6_121890040_121890777 0.14 Mug1
 murinoglobulin 1
 4831
 0.21
chr4_81841873_81842024 0.14 n-R5s187
 nuclear encoded rRNA 5S 187
 76565
 0.1
chr2_69911096_69911271 0.14 Ubr3
 ubiquitin protein ligase E3 component n-recognin 3
 13880
 0.13
chr11_43217118_43217287 0.14 Gm12144
 predicted gene 12144
 15062
 0.19
chr6_50986659_50986810 0.14 Gm44402
 predicted gene, 44402
 19466
 0.22
chr10_115298774_115299175 0.14 Rab21
 RAB21, member RAS oncogene family
 16617
 0.14
chr3_135842259_135842432 0.14 4933401H06Rik
 RIKEN cDNA 4933401H06 gene
 2076
 0.25
chr12_78215748_78215899 0.14 Gphn
 gephyrin
 10556
 0.14
chr7_123124873_123125354 0.14 Tnrc6a
 trinucleotide repeat containing 6a
 857
 0.66
chr3_86560323_86560494 0.14 Mab21l2
 mab-21-like 2
 11779
 0.21
chr13_37665370_37665760 0.14 AI463229
 expressed sequence AI463229
 977
 0.42
chr8_119912901_119913087 0.14 Usp10
 ubiquitin specific peptidase 10
 2137
 0.24
chr2_118318601_118318758 0.14 1700054M17Rik
 RIKEN cDNA 1700054M17 gene
 13765
 0.13
chr5_112908382_112908548 0.14 Myo18b
 myosin XVIIIb
 12103
 0.19
chr11_72737626_72737777 0.14 Ankfy1
 ankyrin repeat and FYVE domain containing 1
 22215
 0.16
chr11_107467010_107467274 0.13 Pitpnc1
 phosphatidylinositol transfer protein, cytoplasmic 1
 3557
 0.15
chr9_121928936_121929087 0.13 Gm47115
 predicted gene, 47115
 5069
 0.09
chr15_75803070_75803233 0.13 Zc3h3
 zinc finger CCCH type containing 3
 9708
 0.12
chr10_63060758_63060924 0.13 Pbld1
 phenazine biosynthesis-like protein domain containing 1
 112
 0.93
chr13_46466566_46466717 0.13 Cap2
 CAP, adenylate cyclase-associated protein, 2 (yeast)
 35207
 0.14

Histogram of CRE-TSS distances for CREs targeted by :

Histogram of

Rank distribution of CRE target scores:

Histogram of target CRE score.

Distribution of target CREs across different genomic regions:

Weighted Piechart of Weighted Piechart of Weighted Piechart of

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx1-1_Nkx1-2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0070827 chromatin maintenance(GO:0070827)
0.1 0.2 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.1 0.2 GO:0071879 positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.1 0.2 GO:0006681 galactosylceramide metabolic process(GO:0006681)
0.0 0.1 GO:0090365 regulation of mRNA modification(GO:0090365)
0.0 0.1 GO:2000836 androgen secretion(GO:0035935) regulation of androgen secretion(GO:2000834) positive regulation of androgen secretion(GO:2000836)
0.0 0.1 GO:1903898 negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0 0.1 GO:0019254 carnitine metabolic process, CoA-linked(GO:0019254)
0.0 0.1 GO:0061470 T follicular helper cell differentiation(GO:0061470)
0.0 0.1 GO:0010912 regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0 0.1 GO:2000054 negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification(GO:2000054)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722)
0.0 0.1 GO:1901078 negative regulation of relaxation of muscle(GO:1901078)
0.0 0.2 GO:0010815 bradykinin catabolic process(GO:0010815)
0.0 0.1 GO:0061052 negative regulation of cell growth involved in cardiac muscle cell development(GO:0061052)
0.0 0.1 GO:0014894 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
0.0 0.1 GO:0021699 cerebellar cortex maturation(GO:0021699)
0.0 0.1 GO:2000019 negative regulation of male gonad development(GO:2000019)
0.0 0.1 GO:0001992 regulation of systemic arterial blood pressure by vasopressin(GO:0001992)
0.0 0.2 GO:0045409 negative regulation of interleukin-6 biosynthetic process(GO:0045409)
0.0 0.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0002669 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
0.0 0.1 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
0.0 0.1 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.0 0.1 GO:2000566 positive regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000566)
0.0 0.1 GO:0021912 regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.0 0.1 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
0.0 0.2 GO:2001214 positive regulation of vasculogenesis(GO:2001214)
0.0 0.1 GO:0009115 xanthine catabolic process(GO:0009115)
0.0 0.1 GO:0014063 negative regulation of serotonin secretion(GO:0014063)
0.0 0.1 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.0 0.1 GO:0051661 maintenance of centrosome location(GO:0051661)
0.0 0.1 GO:0035553 oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0 0.1 GO:0072675 osteoclast fusion(GO:0072675)
0.0 0.1 GO:2000097 regulation of smooth muscle cell-matrix adhesion(GO:2000097)
0.0 0.1 GO:0001543 ovarian follicle rupture(GO:0001543)
0.0 0.1 GO:0097264 self proteolysis(GO:0097264)
0.0 0.1 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0 0.0 GO:0034436 glycoprotein transport(GO:0034436)
0.0 0.1 GO:0035887 aortic smooth muscle cell differentiation(GO:0035887)
0.0 0.1 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.0 0.1 GO:1901142 insulin metabolic process(GO:1901142)
0.0 0.1 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.1 GO:0006621 protein retention in ER lumen(GO:0006621)
0.0 0.1 GO:0009093 cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0 0.1 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.0 0.1 GO:0070837 dehydroascorbic acid transport(GO:0070837)
0.0 0.1 GO:0042738 exogenous drug catabolic process(GO:0042738)
0.0 0.0 GO:1902564 negative regulation of neutrophil activation(GO:1902564)
0.0 0.1 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.0 0.1 GO:0014022 neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007)
0.0 0.1 GO:0021586 pons maturation(GO:0021586)
0.0 0.1 GO:0046813 receptor-mediated virion attachment to host cell(GO:0046813)
0.0 0.1 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.0 0.1 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.0 0.1 GO:0086073 bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 0.0 GO:0038128 ERBB2 signaling pathway(GO:0038128)
0.0 0.0 GO:0048807 female genitalia morphogenesis(GO:0048807)
0.0 0.2 GO:0035278 miRNA mediated inhibition of translation(GO:0035278)
0.0 0.0 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.1 GO:0030091 protein repair(GO:0030091)
0.0 0.1 GO:0036135 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
0.0 0.0 GO:2000564 regulation of CD8-positive, alpha-beta T cell proliferation(GO:2000564)
0.0 0.0 GO:0006741 NADP biosynthetic process(GO:0006741)
0.0 0.0 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0 0.0 GO:0007529 establishment of synaptic specificity at neuromuscular junction(GO:0007529)
0.0 0.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.0 GO:0003331 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
0.0 0.0 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0 0.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
0.0 0.1 GO:0010216 maintenance of DNA methylation(GO:0010216)
0.0 0.1 GO:0042663 regulation of endodermal cell fate specification(GO:0042663)
0.0 0.0 GO:0042322 negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322)
0.0 0.0 GO:1990791 dorsal root ganglion development(GO:1990791)
0.0 0.0 GO:0097503 sialylation(GO:0097503)
0.0 0.1 GO:0007262 STAT protein import into nucleus(GO:0007262)
0.0 0.0 GO:0060800 regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0 0.1 GO:0051547 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0 0.0 GO:0019086 late viral transcription(GO:0019086)
0.0 0.1 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0 0.0 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.0 0.0 GO:0060137 maternal process involved in parturition(GO:0060137)
0.0 0.0 GO:0002018 renin-angiotensin regulation of aldosterone production(GO:0002018)
0.0 0.1 GO:0031508 pericentric heterochromatin assembly(GO:0031508)
0.0 0.0 GO:0070294 renal sodium ion absorption(GO:0070294)
0.0 0.2 GO:0060390 regulation of SMAD protein import into nucleus(GO:0060390)
0.0 0.0 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
0.0 0.1 GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0 0.0 GO:0060318 definitive erythrocyte differentiation(GO:0060318)
0.0 0.1 GO:0019244 lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0 0.0 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.0 0.0 GO:2000670 positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0 0.1 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617) mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.0 0.0 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0 0.0 GO:0065001 specification of axis polarity(GO:0065001)
0.0 0.0 GO:0071462 cellular response to water stimulus(GO:0071462)
0.0 0.0 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.0 0.0 GO:0043622 cortical microtubule organization(GO:0043622)
0.0 0.1 GO:0034374 low-density lipoprotein particle remodeling(GO:0034374)
0.0 0.1 GO:0060613 fat pad development(GO:0060613)
0.0 0.0 GO:1902809 regulation of skeletal muscle fiber differentiation(GO:1902809)
0.0 0.0 GO:0016554 cytidine to uridine editing(GO:0016554)
0.0 0.0 GO:0035054 embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0 0.0 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
0.0 0.0 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
0.0 0.0 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.1 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.1 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.0 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.1 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
0.0 0.0 GO:0035523 protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0 0.0 GO:1900095 regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0 0.0 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0 0.1 GO:0061684 chaperone-mediated autophagy(GO:0061684)
0.0 0.0 GO:0048496 maintenance of organ identity(GO:0048496)
0.0 0.1 GO:0014010 Schwann cell proliferation(GO:0014010)
0.0 0.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.0 GO:0042360 vitamin E metabolic process(GO:0042360)
0.0 0.1 GO:0046501 protoporphyrinogen IX metabolic process(GO:0046501)
0.0 0.0 GO:0019805 quinolinate biosynthetic process(GO:0019805)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0000836 ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0 0.1 GO:1990597 AIP1-IRE1 complex(GO:1990597)
0.0 0.1 GO:1990111 spermatoproteasome complex(GO:1990111)
0.0 0.1 GO:0005899 insulin receptor complex(GO:0005899)
0.0 0.2 GO:0042587 glycogen granule(GO:0042587)
0.0 0.1 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.0 0.1 GO:0000138 Golgi trans cisterna(GO:0000138)
0.0 0.1 GO:0031466 Cul5-RING ubiquitin ligase complex(GO:0031466)
0.0 0.0 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.0 0.0 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.0 0.0 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 0.0 GO:0031523 Myb complex(GO:0031523)
0.0 0.1 GO:0097433 dense body(GO:0097433)
0.0 0.0 GO:0043511 inhibin complex(GO:0043511)
0.0 0.2 GO:0005640 nuclear outer membrane(GO:0005640)
0.0 0.1 GO:0042788 polysomal ribosome(GO:0042788)
0.0 0.0 GO:0070110 ciliary neurotrophic factor receptor complex(GO:0070110)
0.0 0.0 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 0.0 GO:1990246 uniplex complex(GO:1990246)
0.0 0.0 GO:0097443 sorting endosome(GO:0097443)
0.0 0.0 GO:0097425 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0 0.2 GO:0071565 nBAF complex(GO:0071565)
0.0 0.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.0 0.0 GO:0042583 chromaffin granule(GO:0042583)
0.0 0.0 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0 0.0 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.0 0.1 GO:0043202 lysosomal lumen(GO:0043202)
0.0 0.0 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0015205 purine nucleobase transmembrane transporter activity(GO:0005345) pyrimidine nucleobase transmembrane transporter activity(GO:0005350) nucleobase transmembrane transporter activity(GO:0015205)
0.0 0.1 GO:0004144 diacylglycerol O-acyltransferase activity(GO:0004144)
0.0 0.1 GO:0004031 aldehyde oxidase activity(GO:0004031) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623)
0.0 0.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.0 0.1 GO:0001025 RNA polymerase III transcription factor binding(GO:0001025)
0.0 0.1 GO:0004645 phosphorylase activity(GO:0004645)
0.0 0.0 GO:0017098 sulfonylurea receptor binding(GO:0017098)
0.0 0.1 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0034819 3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0 0.1 GO:0035515 oxidative RNA demethylase activity(GO:0035515)
0.0 0.1 GO:0019776 Atg8 ligase activity(GO:0019776)
0.0 0.1 GO:0005000 vasopressin receptor activity(GO:0005000)
0.0 0.2 GO:0050649 testosterone 6-beta-hydroxylase activity(GO:0050649)
0.0 0.1 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0 0.1 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.1 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
0.0 0.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 0.2 GO:0070034 telomerase RNA binding(GO:0070034)
0.0 0.1 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.0 0.0 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
0.0 0.1 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.0 0.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.0 0.1 GO:0032557 pyrimidine ribonucleotide binding(GO:0032557)
0.0 0.0 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.0 0.0 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.1 GO:0042301 phosphate ion binding(GO:0042301)
0.0 0.1 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0 0.1 GO:1990254 keratin filament binding(GO:1990254)
0.0 0.1 GO:0004459 L-lactate dehydrogenase activity(GO:0004459)
0.0 0.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0 0.2 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.0 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
0.0 0.1 GO:1904288 BAT3 complex binding(GO:1904288)
0.0 0.0 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.0 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0071253 connexin binding(GO:0071253)
0.0 0.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.0 0.0 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.0 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.0 0.0 GO:0016823 hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0 0.0 GO:0001884 pyrimidine nucleoside binding(GO:0001884)
0.0 0.1 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.0 0.1 GO:0015385 sodium:proton antiporter activity(GO:0015385) potassium:proton antiporter activity(GO:0015386)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.0 GO:0017116 single-stranded DNA-dependent ATP-dependent DNA helicase activity(GO:0017116)
0.0 0.1 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.0 0.0 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0 0.0 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290)
0.0 0.0 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.0 0.0 GO:0043199 sulfate binding(GO:0043199)
0.0 0.1 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0 0.1 GO:0016443 bidentate ribonuclease III activity(GO:0016443)
0.0 0.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.1 GO:0015198 oligopeptide transporter activity(GO:0015198)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 0.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 0.3 PID REELIN PATHWAY Reelin signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 0.0 REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the early endosome membrane
0.0 0.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.1 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat
0.0 0.1 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.0 0.0 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication