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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Nkx2-5

Z-value: 1.40

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Transcription factors associated with Nkx2-5

Gene Symbol	Gene ID	Gene Info
Nkx2-5 Ensembl NCBI MGI UniProt	ENSMUSG00000015579.4	NK2 homeobox 5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr17_26849650_26849814	Nkx2-5	4723	0.119179	0.91	1.1e-02	Click!
chr17_26845667_26845818	Nkx2-5	733	0.513295	0.87	2.3e-02	Click!
chr17_26825465_26825633	Nkx2-5	16016	0.109326	0.73	9.9e-02	Click!
chr17_26842778_26842936	Nkx2-5	1292	0.303870	-0.55	2.6e-01	Click!
chr17_26850173_26850324	Nkx2-5	5239	0.115242	0.54	2.7e-01	Click!

Activity of the Nkx2-5 motif across conditions

Conditions sorted by the z-value of the Nkx2-5 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr5_125524109_125525122	0.53	Tmem132b	transmembrane protein 132B	7159	0.16
chr8_93186224_93186375	0.49	Gm45909	predicted gene 45909	5059	0.15
chr3_97645418_97646002	0.48	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	12483	0.13
chr15_80672628_80672969	0.46	Fam83f	family with sequence similarity 83, member F	951	0.46
chr2_155574319_155574490	0.42	Gss	glutathione synthetase	21	0.93
chr12_103937089_103937240	0.42	Gm17198	predicted gene 17198	10873	0.1
chr10_81414361_81414714	0.42	Mir1191b	microRNA 1191b	1760	0.13
chr13_101016552_101016703	0.39	Gm6114	predicted gene 6114	2641	0.28
chr14_120256809_120256970	0.38	Mbnl2	muscleblind like splicing factor 2	18780	0.23
chr14_14019581_14019753	0.38	Atxn7	ataxin 7	6523	0.21
chr2_32524318_32524490	0.38	Gm13412	predicted gene 13412	627	0.55
chr8_64849910_64850714	0.37	Klhl2	kelch-like 2, Mayven	295	0.88
chr11_5909584_5909735	0.37	Gck	glucokinase	5465	0.12
chr17_33932704_33933052	0.37	Rgl2	ral guanine nucleotide dissociation stimulator-like 2	747	0.27
chr12_30348373_30348544	0.36	Sntg2	syntrophin, gamma 2	9225	0.26
chr7_30942773_30943144	0.36	Hamp	hepcidin antimicrobial peptide	1074	0.25
chr19_44394826_44394979	0.36	Scd1	stearoyl-Coenzyme A desaturase 1	11788	0.14
chr3_138287619_138288216	0.36	Adh1	alcohol dehydrogenase 1 (class I)	10266	0.12
chr10_4432270_4432710	0.36	Armt1	acidic residue methyltransferase 1	23	0.58
chr4_95585932_95586260	0.35	Fggy	FGGY carbohydrate kinase domain containing	819	0.65
chr3_77945568_77945719	0.34	Gm18719	predicted gene, 18719	15741	0.24
chr5_127635424_127635832	0.34	Slc15a4	solute carrier family 15, member 4	2731	0.23
chr8_61402660_61402821	0.34	Gm7432	predicted gene 7432	21353	0.17
chr12_104346326_104346873	0.34	Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	8113	0.12
chr11_32602058_32602209	0.34	Stk10	serine/threonine kinase 10	13538	0.2
chr16_24395043_24395194	0.34	Lpp	LIM domain containing preferred translocation partner in lipoma	1380	0.39
chr9_48737793_48738215	0.33	Zbtb16	zinc finger and BTB domain containing 16	97941	0.07
chr11_120815283_120815743	0.33	Fasn	fatty acid synthase	58	0.94
chr3_51228745_51228916	0.32	Gm38357	predicted gene, 38357	3087	0.18
chr5_140116324_140116548	0.32	Mad1l1	MAD1 mitotic arrest deficient 1-like 1	970	0.5
chr12_75531904_75532183	0.32	Ppp2r5e	protein phosphatase 2, regulatory subunit B', epsilon	17631	0.18
chr19_10904836_10905155	0.32	Prpf19	pre-mRNA processing factor 19	4713	0.11
chr15_44676679_44676830	0.31	Ebag9	estrogen receptor-binding fragment-associated gene 9	57163	0.12
chr18_33386685_33386850	0.31	Gm5503	predicted gene 5503	1812	0.45
chr2_31495950_31496143	0.31	Ass1	argininosuccinate synthetase 1	1726	0.35
chr7_4814451_4814602	0.30	Ube2s	ubiquitin-conjugating enzyme E2S	1936	0.15
chr6_53995355_53995609	0.30	4921529L05Rik	RIKEN cDNA 4921529L05 gene	14230	0.18
chr17_28050588_28050750	0.30	Anks1	ankyrin repeat and SAM domain containing 1	3664	0.15
chr16_34959125_34959276	0.30	E130310I04Rik	RIKEN cDNA E130310I04 gene	206	0.93
chr5_36120892_36121056	0.30	Psapl1	prosaposin-like 1	83047	0.09
chr9_44222845_44223011	0.29	Cbl	Casitas B-lineage lymphoma	10616	0.08
chr1_191847103_191847254	0.29	Nek2	NIMA (never in mitosis gene a)-related expressed kinase 2	20030	0.13
chr10_113290132_113290294	0.29	Gm47532	predicted gene, 47532	133971	0.05
chr3_146501639_146502276	0.29	Gng5	guanine nucleotide binding protein (G protein), gamma 5	1848	0.22
chr7_24928137_24928288	0.29	Arhgef1	Rho guanine nucleotide exchange factor (GEF) 1	4849	0.1
chr12_71933735_71933954	0.29	Daam1	dishevelled associated activator of morphogenesis 1	44114	0.15
chr7_81707314_81707700	0.29	Homer2	homer scaffolding protein 2	20	0.97
chr1_193231551_193231702	0.29	Hsd11b1	hydroxysteroid 11-beta dehydrogenase 1	7397	0.11
chr2_85249002_85249153	0.29	Gm13715	predicted gene 13715	15402	0.12
chr3_97650901_97651052	0.29	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	7217	0.14
chr2_120609489_120609836	0.28	Haus2	HAUS augmin-like complex, subunit 2	67	0.6
chr16_45975826_45976145	0.28	Phldb2	pleckstrin homology like domain, family B, member 2	22387	0.14
chr1_172168265_172168469	0.28	Dcaf8	DDB1 and CUL4 associated factor 8	5587	0.11
chr5_125171150_125171678	0.28	Ncor2	nuclear receptor co-repressor 2	7639	0.23
chr6_6280678_6280863	0.28	Gm20619	predicted gene 20619	18651	0.18
chr11_78160013_78160257	0.28	Traf4	TNF receptor associated factor 4	5381	0.07
chr2_162940006_162940177	0.28	L3mbtl1	L3MBTL1 histone methyl-lysine binding protein	3381	0.16
chr11_50312756_50312907	0.27	Canx	calnexin	11841	0.12
chr19_37323790_37323978	0.27	Ide	insulin degrading enzyme	6729	0.16
chr12_57399630_57399818	0.27	Gm16246	predicted gene 16246	50396	0.13
chr11_5905000_5905191	0.27	Gck	glucokinase	3008	0.15
chr10_22153060_22153299	0.27	Gm4895	predicted gene 4895	1237	0.28
chr15_95835869_95836082	0.27	Gm17546	predicted gene, 17546	5903	0.16
chr4_76334623_76334919	0.27	Ptprd	protein tyrosine phosphatase, receptor type, D	9472	0.28
chr16_49787017_49787230	0.27	Gm15518	predicted gene 15518	11747	0.22
chr11_88841898_88842065	0.27	Akap1	A kinase (PRKA) anchor protein 1	441	0.8
chr8_79710908_79711237	0.27	Abce1	ATP-binding cassette, sub-family E (OABP), member 1	578	0.48
chr2_143992101_143992400	0.26	Rrbp1	ribosome binding protein 1	9085	0.19
chr18_34888734_34888885	0.26	Egr1	early growth response 1	27602	0.11
chr1_181212615_181213074	0.26	Wdr26	WD repeat domain 26	843	0.53
chr4_45475445_45475639	0.26	Shb	src homology 2 domain-containing transforming protein B	7260	0.17
chr12_104081605_104081762	0.26	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	1034	0.36
chr7_112372608_112372767	0.26	Mical2	microtubule associated monooxygenase, calponin and LIM domain containing 2	1658	0.48
chr13_34635371_34635522	0.26	Pxdc1	PX domain containing 1	13122	0.13
chr1_21248546_21248733	0.26	Gsta3	glutathione S-transferase, alpha 3	4882	0.13
chr18_75675824_75676322	0.25	Ctif	CBP80/20-dependent translation initiation factor	21481	0.23
chr17_45566542_45566693	0.25	Slc35b2	solute carrier family 35, member B2	1878	0.17
chr3_52646413_52646568	0.25	Gm10293	predicted pseudogene 10293	33655	0.18
chr5_28943694_28943878	0.25	Rnf32	ring finger protein 32	252206	0.02
chr2_34779244_34779475	0.25	Hspa5	heat shock protein 5	4512	0.15
chr13_54439539_54439690	0.25	Thoc3	THO complex 3	29174	0.12
chr15_59002495_59002896	0.25	4930544F09Rik	RIKEN cDNA 4930544F09 gene	18559	0.16
chr16_45996562_45996713	0.25	Plcxd2	phosphatidylinositol-specific phospholipase C, X domain containing 2	13581	0.16
chr1_21266470_21266781	0.25	Gm28836	predicted gene 28836	4968	0.12
chr19_6052682_6052868	0.25	Mir6988	microRNA 6988	1441	0.13
chr11_106889132_106889465	0.25	Smurf2	SMAD specific E3 ubiquitin protein ligase 2	30977	0.11
chr18_64334411_64334587	0.25	St8sia3os	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3, opposite strand	793	0.6
chr8_117107626_117107786	0.25	Bco1	beta-carotene oxygenase 1	11708	0.16
chr3_21963115_21963409	0.25	Gm43674	predicted gene 43674	35206	0.17
chr1_21246529_21246960	0.25	Gsta3	glutathione S-transferase, alpha 3	6115	0.12
chr6_90746922_90747105	0.25	Iqsec1	IQ motif and Sec7 domain 1	10326	0.17
chr8_88203572_88203796	0.24	Tent4b	terminal nucleotidyltransferase 4B	4470	0.18
chr11_67428302_67428473	0.24	Gas7	growth arrest specific 7	26704	0.2
chr9_101114305_101114456	0.24	Gm37962	predicted gene, 37962	575	0.6
chr2_174472267_174472486	0.24	Prelid3b	PRELI domain containing 3B	515	0.68
chr3_129593850_129594054	0.24	Elovl6	ELOVL family member 6, elongation of long chain fatty acids (yeast)	41572	0.12
chr8_88209570_88209916	0.24	Tent4b	terminal nucleotidyltransferase 4B	10529	0.16
chr11_50292954_50293105	0.24	Maml1	mastermind like transcriptional coactivator 1	718	0.55
chr9_72702491_72702671	0.24	Nedd4	neural precursor cell expressed, developmentally down-regulated 4	9142	0.1
chr10_22152293_22152666	0.24	Gm4895	predicted gene 4895	1937	0.18
chrX_140591571_140591781	0.24	AL683809.1	TSC22 domain family, member 3 (Tsc22d3), pseuodgene	8077	0.17
chr10_20186534_20186685	0.24	Map7	microtubule-associated protein 7	14602	0.15
chr16_33937944_33938095	0.24	Itgb5	integrin beta 5	8505	0.17
chr4_122960418_122960596	0.24	Mfsd2a	major facilitator superfamily domain containing 2A	517	0.56
chr15_95749618_95750040	0.24	Gm6961	predicted gene 6961	1762	0.25
chr1_187505276_187505427	0.24	Gm37896	predicted gene, 37896	57474	0.13
chr1_51771229_51771422	0.24	Myo1b	myosin IB	446	0.84
chr6_147954211_147954549	0.24	Far2	fatty acyl CoA reductase 2	92879	0.07
chr6_99301780_99301979	0.23	Foxp1	forkhead box P1	35347	0.2
chr3_14831219_14831555	0.23	Car1	carbonic anhydrase 1	23019	0.15
chr9_8079032_8079205	0.23	Cep126	centrosomal protein 126	8181	0.18
chr14_65615417_65615662	0.23	Nuggc	nuclear GTPase, germinal center associated	10272	0.2
chr9_55210561_55210712	0.23	Fbxo22	F-box protein 22	1446	0.38
chr9_57262499_57262900	0.23	1700017B05Rik	RIKEN cDNA 1700017B05 gene	87	0.96
chr1_67213641_67214357	0.23	Gm15668	predicted gene 15668	35201	0.17
chr1_51780537_51780819	0.23	Myo1b	myosin IB	1526	0.42
chr8_110621328_110621479	0.23	Vac14	Vac14 homolog (S. cerevisiae)	2791	0.29
chr13_96569767_96570095	0.22	Gm46436	predicted gene, 46436	6699	0.13
chr5_115032657_115032942	0.22	C730045M19Rik	RIKEN cDNA C730045M19 gene	6971	0.11
chr10_80958823_80958991	0.22	Gm3828	predicted gene 3828	4197	0.12
chr11_72683212_72683363	0.22	Ankfy1	ankyrin repeat and FYVE domain containing 1	6719	0.18
chr1_51761473_51761660	0.22	Myo1b	myosin IB	2904	0.27
chr18_46751644_46751795	0.22	Ap3s1	adaptor-related protein complex 3, sigma 1 subunit	5896	0.12
chr7_121033932_121034119	0.22	Mettl9	methyltransferase like 9	420	0.6
chr5_88733550_88733701	0.22	Gm15682	predicted gene 15682	6104	0.16
chr2_125617617_125617780	0.22	Cep152	centrosomal protein 152	7415	0.23
chr7_98419217_98419418	0.22	Gm44507	predicted gene 44507	3693	0.16
chr17_86781235_86781386	0.22	Gm50008	predicted gene, 50008	8040	0.19
chr19_4582196_4582347	0.22	Pcx	pyruvate carboxylase	12075	0.12
chr9_96966105_96966535	0.22	Spsb4	splA/ryanodine receptor domain and SOCS box containing 4	5655	0.18
chr15_3475054_3475205	0.22	Ghr	growth hormone receptor	3485	0.35
chr6_83455439_83455881	0.22	Tet3	tet methylcytosine dioxygenase 3	732	0.54
chr17_88550882_88551070	0.22	Ppp1r21	protein phosphatase 1, regulatory subunit 21	11141	0.17
chr5_28048047_28048198	0.22	Gm26608	predicted gene, 26608	7337	0.16
chr3_96630277_96630623	0.22	Rbm8a	RNA binding motif protein 8a	253	0.67
chr4_101227195_101227372	0.22	Gm12785	predicted gene 12785	16696	0.14
chr11_51777861_51778012	0.22	Sar1b	secretion associated Ras related GTPase 1B	14242	0.15
chr14_63266242_63266413	0.21	Gata4	GATA binding protein 4	4797	0.2
chr18_33386505_33386656	0.21	Gm5503	predicted gene 5503	1625	0.48
chr18_56756491_56756863	0.21	Gm15345	predicted gene 15345	13040	0.18
chr5_66063805_66063956	0.21	Gm43775	predicted gene 43775	9015	0.12
chr11_7815566_7815774	0.21	Gm27393	predicted gene, 27393	70835	0.13
chrX_98148456_98149039	0.21	Ar	androgen receptor	22	0.99
chr3_97645176_97645416	0.21	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	12897	0.12
chr12_98716508_98716741	0.21	Ptpn21	protein tyrosine phosphatase, non-receptor type 21	17189	0.12
chr17_83175556_83175768	0.21	Pkdcc	protein kinase domain containing, cytoplasmic	39630	0.15
chr13_101216709_101217201	0.21	5930438M14Rik	RIKEN cDNA 5930438M14 gene	15172	0.22
chr11_58803831_58803982	0.21	Fam183b	family with sequence similarity 183, member B	1946	0.15
chr6_128843572_128843953	0.21	Gm44066	predicted gene, 44066	591	0.53
chr9_48767602_48767753	0.21	Zbtb16	zinc finger and BTB domain containing 16	68268	0.11
chr8_24431137_24431348	0.21	Tcim	transcriptional and immune response regulator	7742	0.15
chr15_3265518_3265894	0.21	Selenop	selenoprotein P	2841	0.29
chr7_79273325_79273476	0.21	Abhd2	abhydrolase domain containing 2	146	0.74
chr4_57056918_57057155	0.21	Epb41l4b	erythrocyte membrane protein band 4.1 like 4b	13523	0.21
chr19_12635033_12635481	0.21	Glyat	glycine-N-acyltransferase	1724	0.21
chr7_81002031_81002182	0.21	Gm44967	predicted gene 44967	7423	0.11
chr1_194623995_194624148	0.21	Plxna2	plexin A2	4246	0.22
chr1_60545486_60545637	0.21	Gm11576	predicted gene 11576	8541	0.14
chr3_36483169_36483342	0.21	1810062G17Rik	RIKEN cDNA 1810062G17 gene	7318	0.12
chr8_125012381_125013106	0.21	Tsnax	translin-associated factor X	254	0.9
chr14_69273994_69274169	0.21	Gm20236	predicted gene, 20236	8059	0.09
chr5_140113628_140113854	0.21	Mad1l1	MAD1 mitotic arrest deficient 1-like 1	1725	0.31
chr18_45560710_45560886	0.21	Kcnn2	potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2	644	0.46
chr7_130709369_130709776	0.21	Tacc2	transforming, acidic coiled-coil containing protein 2	4105	0.22
chr5_140129593_140129908	0.21	Mad1l1	MAD1 mitotic arrest deficient 1-like 1	14284	0.15
chr1_13588395_13588599	0.21	Tram1	translocating chain-associating membrane protein 1	1378	0.46
chr5_125348811_125348962	0.20	Scarb1	scavenger receptor class B, member 1	7792	0.13
chr15_59074795_59075357	0.20	Mtss1	MTSS I-BAR domain containing 1	6913	0.24
chr1_58089710_58089862	0.20	Aox3	aldehyde oxidase 3	23344	0.16
chr14_69492248_69492419	0.20	Gm37094	predicted gene, 37094	8057	0.1
chr15_103102516_103102843	0.20	Gm10830	predicted gene 10830	442	0.48
chr6_31223178_31223357	0.20	Lncpint	long non-protein coding RNA, Trp53 induced transcript	2779	0.21
chr7_30964100_30964320	0.20	Gm4673	predicted gene 4673	6801	0.07
chr1_91410552_91410703	0.20	Hes6	hairy and enhancer of split 6	2581	0.16
chr16_34070223_34070399	0.20	Kalrn	kalirin, RhoGEF kinase	25676	0.2
chr3_105688069_105688239	0.20	Ddx20	DEAD (Asp-Glu-Ala-Asp) box polypeptide 20	580	0.66
chr11_98863094_98863383	0.20	Wipf2	WAS/WASL interacting protein family, member 2	400	0.74
chr15_80684645_80684861	0.20	A430088P11Rik	RIKEN cDNA A430088P11 gene	12849	0.12
chr11_80974473_80974624	0.20	Gm11416	predicted gene 11416	72246	0.1
chr1_87798879_87799044	0.20	Sag	S-antigen, retina and pineal gland (arrestin)	4719	0.14
chr9_67299245_67299416	0.20	Tln2	talin 2	2887	0.33
chr9_123589393_123589544	0.20	Sacm1l	SAC1 suppressor of actin mutations 1-like (yeast)	2980	0.19
chr4_134837509_134837670	0.20	Maco1	macoilin 1	15560	0.17
chr13_68232445_68232596	0.20	AA414992	expressed sequence AA414992	51226	0.15
chr12_75468533_75468684	0.20	Gm47690	predicted gene, 47690	40137	0.15
chr12_83544747_83544898	0.20	Zfyve1	zinc finger, FYVE domain containing 1	6883	0.16
chr4_104999245_104999429	0.20	Gm12721	predicted gene 12721	29208	0.21
chr8_70799557_70799708	0.20	Mir7240	microRNA 7240	1497	0.17
chr18_11145088_11145239	0.20	Gata6	GATA binding protein 6	86116	0.09
chr1_21245041_21245248	0.20	Gsta3	glutathione S-transferase, alpha 3	4515	0.13
chr11_38681637_38681852	0.20	Gm23520	predicted gene, 23520	116533	0.07
chr2_31513523_31513683	0.20	Ass1	argininosuccinate synthetase 1	4887	0.19
chr8_29766619_29766793	0.19	Gm45492	predicted gene 45492	315254	0.01
chr11_84029791_84029973	0.19	Synrg	synergin, gamma	3227	0.24
chr7_99075490_99075673	0.19	Gm33882	predicted gene, 33882	14651	0.15
chr15_99032417_99032770	0.19	Tuba1c	tubulin, alpha 1C	2272	0.15
chr19_44111938_44112122	0.19	Cwf19l1	CWF19-like 1, cell cycle control (S. pombe)	968	0.39
chr16_4182796_4182947	0.19	Gm37186	predicted gene, 37186	9235	0.17
chr12_59194644_59194808	0.19	Fbxo33	F-box protein 33	9710	0.14
chr15_89128163_89128341	0.19	Hdac10	histone deacetylase 10	196	0.87

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-5

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0045726	positive regulation of integrin biosynthetic process(GO:0045726)
0.1	0.2	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.1	0.3	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.3	GO:0071455	cellular response to increased oxygen levels(GO:0036295) cellular response to hyperoxia(GO:0071455)
0.1	0.1	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1	0.2	GO:0006068	ethanol catabolic process(GO:0006068)
0.1	0.2	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.1	GO:1902474	positive regulation of protein localization to synapse(GO:1902474)
0.1	0.2	GO:0034755	iron ion transmembrane transport(GO:0034755)
0.1	0.2	GO:0003162	atrioventricular node development(GO:0003162)
0.1	0.2	GO:0010046	response to mycotoxin(GO:0010046)
0.1	0.2	GO:0002036	regulation of L-glutamate transport(GO:0002036)
0.1	0.2	GO:0006295	nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1	0.1	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.1	0.2	GO:0046449	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.1	0.2	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.1	0.2	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.1	0.2	GO:1904526	regulation of microtubule binding(GO:1904526) positive regulation of microtubule binding(GO:1904528)
0.1	0.2	GO:0034146	toll-like receptor 5 signaling pathway(GO:0034146)
0.1	0.2	GO:1902730	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.1	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.1	0.2	GO:1904380	endoplasmic reticulum mannose trimming(GO:1904380)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.2	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.2	GO:1900194	negative regulation of oocyte maturation(GO:1900194)
0.0	0.2	GO:0039536	negative regulation of RIG-I signaling pathway(GO:0039536)
0.0	0.1	GO:0009732	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.3	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.1	GO:0000710	meiotic mismatch repair(GO:0000710)
0.0	0.1	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0	0.1	GO:0030167	proteoglycan catabolic process(GO:0030167)
0.0	0.2	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.2	GO:0003195	tricuspid valve morphogenesis(GO:0003186) tricuspid valve formation(GO:0003195)
0.0	0.1	GO:1901252	regulation of intracellular transport of viral material(GO:1901252)
0.0	0.1	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.2	GO:0006681	galactosylceramide metabolic process(GO:0006681)
0.0	0.1	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0015747	urate transport(GO:0015747)
0.0	0.1	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
0.0	0.1	GO:1904339	negative regulation of dopaminergic neuron differentiation(GO:1904339)
0.0	0.2	GO:0051534	negative regulation of NFAT protein import into nucleus(GO:0051534)
0.0	0.2	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.1	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.1	GO:0071947	protein deubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0071947)
0.0	0.2	GO:0061724	lipophagy(GO:0061724)
0.0	0.1	GO:0019853	L-ascorbic acid biosynthetic process(GO:0019853)
0.0	0.1	GO:0048696	regulation of collateral sprouting in absence of injury(GO:0048696)
0.0	0.1	GO:0018894	dibenzo-p-dioxin metabolic process(GO:0018894)
0.0	0.1	GO:0009173	UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.0	0.2	GO:1904424	regulation of GTP binding(GO:1904424)
0.0	0.1	GO:2000382	positive regulation of mesoderm development(GO:2000382)
0.0	0.1	GO:0036023	limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0	0.0	GO:0035519	protein K29-linked ubiquitination(GO:0035519)
0.0	0.1	GO:1902990	mitotic telomere maintenance via semi-conservative replication(GO:1902990)
0.0	0.1	GO:2001245	regulation of phosphatidylcholine biosynthetic process(GO:2001245)
0.0	0.4	GO:0006750	glutathione biosynthetic process(GO:0006750)
0.0	0.1	GO:0035865	response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.0	0.9	GO:0071353	cellular response to interleukin-4(GO:0071353)
0.0	0.4	GO:0007216	G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.0	0.1	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.1	GO:0070346	positive regulation of fat cell proliferation(GO:0070346)
0.0	0.1	GO:0048807	female genitalia morphogenesis(GO:0048807)
0.0	0.1	GO:0097680	double-strand break repair via classical nonhomologous end joining(GO:0097680)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:1904849	positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
0.0	0.2	GO:0071763	nuclear membrane organization(GO:0071763)
0.0	0.1	GO:0000432	regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
0.0	0.1	GO:0044314	protein K27-linked ubiquitination(GO:0044314)
0.0	0.1	GO:0071043	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:0018199	peptidyl-glutamine modification(GO:0018199)
0.0	0.1	GO:0031086	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.1	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.0	GO:0060283	negative regulation of oocyte development(GO:0060283)
0.0	0.1	GO:0003062	regulation of heart rate by chemical signal(GO:0003062)
0.0	0.1	GO:0009438	methylglyoxal metabolic process(GO:0009438)
0.0	0.0	GO:0032489	regulation of Cdc42 protein signal transduction(GO:0032489)
0.0	0.1	GO:0030638	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.1	GO:0039689	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.1	GO:0006420	arginyl-tRNA aminoacylation(GO:0006420)
0.0	0.0	GO:1990314	cellular response to insulin-like growth factor stimulus(GO:1990314)
0.0	0.1	GO:1903998	regulation of eating behavior(GO:1903998)
0.0	0.1	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0035509	negative regulation of myosin-light-chain-phosphatase activity(GO:0035509)
0.0	0.1	GO:0097461	ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.0	0.2	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.1	GO:0002121	inter-male aggressive behavior(GO:0002121)
0.0	0.1	GO:0042726	flavin-containing compound metabolic process(GO:0042726)
0.0	0.1	GO:0044789	modulation by host of viral release from host cell(GO:0044789) positive regulation by host of viral release from host cell(GO:0044791)
0.0	0.1	GO:2000675	negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.0	0.1	GO:1902302	regulation of potassium ion export(GO:1902302)
0.0	0.1	GO:0018243	protein O-linked glycosylation via threonine(GO:0018243)
0.0	0.1	GO:0030070	insulin processing(GO:0030070)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.2	GO:0019441	tryptophan catabolic process(GO:0006569) tryptophan catabolic process to kynurenine(GO:0019441) indole-containing compound catabolic process(GO:0042436) indolalkylamine catabolic process(GO:0046218)
0.0	0.1	GO:0015867	ATP transport(GO:0015867)
0.0	0.2	GO:1900363	regulation of mRNA polyadenylation(GO:1900363)
0.0	0.1	GO:0061625	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.1	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.0	0.1	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.1	GO:1900095	regulation of dosage compensation by inactivation of X chromosome(GO:1900095)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.0	0.2	GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.1	GO:0018095	protein polyglutamylation(GO:0018095)
0.0	0.1	GO:0072386	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0033629	negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.0	0.1	GO:0071830	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.1	GO:0032066	nucleolus to nucleoplasm transport(GO:0032066)
0.0	0.1	GO:0051013	microtubule severing(GO:0051013)
0.0	0.2	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.0	GO:0035973	aggrephagy(GO:0035973)
0.0	0.1	GO:0009074	aromatic amino acid family catabolic process(GO:0009074)
0.0	0.1	GO:1902268	negative regulation of polyamine transmembrane transport(GO:1902268)
0.0	0.0	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.0	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.0	0.1	GO:0048022	negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
0.0	0.0	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.3	GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
0.0	0.1	GO:1903599	positive regulation of mitophagy(GO:1903599)
0.0	0.1	GO:0008635	activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.0	0.1	GO:0035553	oxidative RNA demethylation(GO:0035513) oxidative single-stranded RNA demethylation(GO:0035553)
0.0	0.1	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.0	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.1	GO:0050747	positive regulation of lipoprotein metabolic process(GO:0050747)
0.0	0.0	GO:0009223	pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.0	0.0	GO:0044828	negative regulation by host of viral genome replication(GO:0044828)
0.0	0.1	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.0	0.1	GO:0070131	positive regulation of mitochondrial translation(GO:0070131)
0.0	0.1	GO:0016561	protein import into peroxisome matrix, translocation(GO:0016561)
0.0	0.1	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
0.0	0.1	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.1	GO:0021603	cranial nerve formation(GO:0021603)
0.0	0.0	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.1	GO:0060971	embryonic heart tube left/right pattern formation(GO:0060971)
0.0	0.1	GO:0060689	cell differentiation involved in salivary gland development(GO:0060689)
0.0	0.1	GO:0032497	detection of lipopolysaccharide(GO:0032497)
0.0	0.1	GO:0033668	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.0	0.1	GO:0007258	JUN phosphorylation(GO:0007258)
0.0	0.1	GO:0035627	ceramide transport(GO:0035627)
0.0	0.1	GO:0046602	regulation of mitotic centrosome separation(GO:0046602)
0.0	0.1	GO:0006265	DNA topological change(GO:0006265)
0.0	0.0	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.1	GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0	0.1	GO:0048633	positive regulation of skeletal muscle tissue growth(GO:0048633)
0.0	0.1	GO:0090427	activation of meiosis(GO:0090427)
0.0	0.1	GO:0034551	respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.1	GO:0071799	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	0.0	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.1	GO:0044860	protein localization to plasma membrane raft(GO:0044860)
0.0	0.1	GO:0042447	hormone catabolic process(GO:0042447)
0.0	0.1	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.0	0.1	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0060468	prevention of polyspermy(GO:0060468)
0.0	0.1	GO:0006419	alanyl-tRNA aminoacylation(GO:0006419)
0.0	0.1	GO:0060373	regulation of ventricular cardiac muscle cell membrane depolarization(GO:0060373)
0.0	0.1	GO:0035360	positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.0	GO:0008655	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.0	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.1	GO:0086013	membrane repolarization during cardiac muscle cell action potential(GO:0086013)
0.0	0.4	GO:0070979	protein K11-linked ubiquitination(GO:0070979)
0.0	0.1	GO:0009130	pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
0.0	0.0	GO:0036507	protein deglycosylation involved in glycoprotein catabolic process(GO:0035977) protein demannosylation(GO:0036507) protein alpha-1,2-demannosylation(GO:0036508) mannose trimming involved in glycoprotein ERAD pathway(GO:1904382)
0.0	0.1	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.2	GO:0006415	translational termination(GO:0006415)
0.0	0.1	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.1	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.1	GO:0007253	cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.0	0.1	GO:0008063	Toll signaling pathway(GO:0008063)
0.0	0.0	GO:0033184	positive regulation of histone ubiquitination(GO:0033184)
0.0	0.0	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.1	GO:0003406	retinal pigment epithelium development(GO:0003406)
0.0	0.0	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.1	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.0	0.0	GO:1901165	positive regulation of trophoblast cell migration(GO:1901165)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.0	GO:0071787	endoplasmic reticulum tubular network assembly(GO:0071787)
0.0	0.1	GO:1901339	regulation of store-operated calcium channel activity(GO:1901339)
0.0	0.1	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.0	GO:0051176	positive regulation of sulfur metabolic process(GO:0051176)
0.0	0.1	GO:0046208	spermine catabolic process(GO:0046208)
0.0	0.1	GO:1901552	positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.0	0.0	GO:0035093	spermatogenesis, exchange of chromosomal proteins(GO:0035093)
0.0	0.1	GO:0071985	multivesicular body sorting pathway(GO:0071985)
0.0	0.0	GO:0055005	ventricular cardiac myofibril assembly(GO:0055005)
0.0	0.1	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	0.1	GO:2000197	regulation of mRNA export from nucleus(GO:0010793) regulation of ribonucleoprotein complex localization(GO:2000197)
0.0	0.1	GO:2000301	negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.0	0.1	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.0	0.1	GO:2000676	regulation of type B pancreatic cell apoptotic process(GO:2000674) positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.0	0.0	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.0	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.1	GO:0033564	anterior/posterior axon guidance(GO:0033564)
0.0	0.0	GO:0045472	response to ether(GO:0045472)
0.0	0.0	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.0	GO:0046836	glycolipid transport(GO:0046836)
0.0	0.0	GO:0048069	eye pigmentation(GO:0048069)
0.0	0.1	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.0	GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.2	GO:0070050	neuron cellular homeostasis(GO:0070050)
0.0	0.1	GO:0090209	negative regulation of triglyceride metabolic process(GO:0090209)
0.0	0.1	GO:0015780	nucleotide-sugar transport(GO:0015780) pyrimidine nucleotide-sugar transport(GO:0015781)
0.0	0.0	GO:1903334	positive regulation of protein folding(GO:1903334)
0.0	0.0	GO:1902775	mitochondrial ribosome assembly(GO:0061668) mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.0	GO:0006562	proline catabolic process(GO:0006562)
0.0	0.0	GO:0060447	bud outgrowth involved in lung branching(GO:0060447)
0.0	0.1	GO:0098532	histone H3-K27 trimethylation(GO:0098532)
0.0	0.1	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.0	0.0	GO:0010963	regulation of L-arginine import(GO:0010963)
0.0	0.0	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.1	GO:0006564	L-serine biosynthetic process(GO:0006564)
0.0	0.0	GO:1903044	protein transport into membrane raft(GO:0032596) protein localization to membrane raft(GO:1903044)
0.0	0.1	GO:2000015	regulation of determination of dorsal identity(GO:2000015)
0.0	0.0	GO:2000347	positive regulation of hepatocyte proliferation(GO:2000347)
0.0	0.1	GO:0010867	positive regulation of triglyceride biosynthetic process(GO:0010867)
0.0	0.1	GO:0019509	L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.0	0.0	GO:0010958	regulation of amino acid import(GO:0010958)
0.0	0.1	GO:1905206	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.1	GO:0072488	ammonium transmembrane transport(GO:0072488)
0.0	0.0	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.2	GO:0043248	proteasome assembly(GO:0043248)
0.0	0.0	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.1	GO:0044766	multi-organism transport(GO:0044766) multi-organism localization(GO:1902579)
0.0	0.0	GO:0061535	glutamate secretion, neurotransmission(GO:0061535)
0.0	0.0	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.0	GO:0019254	carnitine metabolic process, CoA-linked(GO:0019254)
0.0	0.1	GO:0060352	cell adhesion molecule production(GO:0060352)
0.0	0.1	GO:0080182	histone H3-K4 trimethylation(GO:0080182)
0.0	0.1	GO:0046512	diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512)
0.0	0.0	GO:0035434	copper ion transmembrane transport(GO:0035434)
0.0	0.4	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.0	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.0	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:0045626	negative regulation of T-helper 1 cell differentiation(GO:0045626)
0.0	0.1	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.0	0.1	GO:0018211	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.0	GO:1902262	apoptotic process involved in patterning of blood vessels(GO:1902262)
0.0	0.0	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.0	GO:2000143	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.2	GO:0006613	cotranslational protein targeting to membrane(GO:0006613)
0.0	0.0	GO:0085020	protein K6-linked ubiquitination(GO:0085020)
0.0	0.1	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.2	GO:0060009	Sertoli cell development(GO:0060009)
0.0	0.1	GO:0021778	oligodendrocyte cell fate specification(GO:0021778) oligodendrocyte cell fate commitment(GO:0021779) glial cell fate specification(GO:0021780)
0.0	0.0	GO:0009162	deoxyribonucleoside monophosphate metabolic process(GO:0009162)
0.0	0.0	GO:0035964	COPI-coated vesicle budding(GO:0035964)
0.0	0.1	GO:0098728	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0	0.0	GO:0006772	thiamine metabolic process(GO:0006772) thiamine-containing compound metabolic process(GO:0042723)
0.0	0.0	GO:0034196	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.1	GO:0001765	membrane raft assembly(GO:0001765)
0.0	0.0	GO:0010936	negative regulation of macrophage cytokine production(GO:0010936)
0.0	0.1	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0	0.1	GO:0006620	posttranslational protein targeting to membrane(GO:0006620)
0.0	0.1	GO:0072310	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.1	GO:1903298	regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0	0.1	GO:0044845	cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506) cell wall biogenesis(GO:0042546) cell wall macromolecule biosynthetic process(GO:0044038) chain elongation of O-linked mannose residue(GO:0044845) cellular component macromolecule biosynthetic process(GO:0070589)
0.0	0.0	GO:0002457	T cell antigen processing and presentation(GO:0002457)
0.0	0.0	GO:0071681	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.0	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.0	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.0	GO:0045743	positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.0	0.0	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0	0.1	GO:0060742	epithelial cell differentiation involved in prostate gland development(GO:0060742)
0.0	0.0	GO:1902626	assembly of large subunit precursor of preribosome(GO:1902626)
0.0	0.0	GO:0010446	response to alkaline pH(GO:0010446)
0.0	0.0	GO:0048625	myoblast fate commitment(GO:0048625)
0.0	0.0	GO:0036072	intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.0	0.1	GO:0015670	carbon dioxide transport(GO:0015670)
0.0	0.0	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.0	0.0	GO:0006862	nucleotide transport(GO:0006862)
0.0	0.0	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187)
0.0	0.1	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0072513	positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0	0.1	GO:0006047	UDP-N-acetylglucosamine metabolic process(GO:0006047)
0.0	0.0	GO:0061083	regulation of protein refolding(GO:0061083) negative regulation of protein refolding(GO:0061084)
0.0	0.0	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.0	GO:1904059	regulation of locomotor rhythm(GO:1904059)
0.0	0.0	GO:0072697	protein localization to cell cortex(GO:0072697)
0.0	0.0	GO:0046874	quinolinate metabolic process(GO:0046874)
0.0	0.0	GO:0000160	phosphorelay signal transduction system(GO:0000160)
0.0	0.1	GO:0051547	regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.0	0.0	GO:0045719	negative regulation of glycogen biosynthetic process(GO:0045719)
0.0	0.0	GO:0038028	insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
0.0	0.1	GO:0070493	thrombin receptor signaling pathway(GO:0070493)
0.0	0.1	GO:0045176	apical protein localization(GO:0045176)
0.0	0.0	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.0	GO:0035799	ureter maturation(GO:0035799)
0.0	0.0	GO:0060684	epithelial-mesenchymal cell signaling(GO:0060684)
0.0	0.0	GO:0072095	regulation of branch elongation involved in ureteric bud branching(GO:0072095)
0.0	0.0	GO:0003140	determination of left/right asymmetry in lateral mesoderm(GO:0003140) nodal signaling pathway involved in determination of left/right asymmetry(GO:0038107) regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry(GO:1900094) nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900164)
0.0	0.0	GO:0060501	positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794)
0.0	0.0	GO:0060011	Sertoli cell proliferation(GO:0060011)
0.0	0.0	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.0	GO:2000074	regulation of type B pancreatic cell development(GO:2000074)
0.0	0.0	GO:0035789	cell migration involved in metanephros development(GO:0035788) metanephric mesenchymal cell migration(GO:0035789) positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) regulation of metanephric mesenchymal cell migration(GO:2000589) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0	0.0	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.0	GO:0098535	de novo centriole assembly(GO:0098535)
0.0	0.0	GO:0015766	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.0	GO:1903361	protein localization to basolateral plasma membrane(GO:1903361)
0.0	0.1	GO:0002934	desmosome organization(GO:0002934)
0.0	0.0	GO:0006000	fructose metabolic process(GO:0006000)
0.0	0.1	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:0080154	regulation of fertilization(GO:0080154)
0.0	0.0	GO:0046831	regulation of RNA export from nucleus(GO:0046831)
0.0	0.0	GO:0021553	olfactory nerve development(GO:0021553)
0.0	0.1	GO:1902170	cellular response to reactive nitrogen species(GO:1902170)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	GO:0042587	glycogen granule(GO:0042587)
0.1	0.2	GO:0030981	cortical microtubule cytoskeleton(GO:0030981)
0.1	0.1	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.1	0.2	GO:0005955	calcineurin complex(GO:0005955)
0.0	0.3	GO:0035032	phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0	0.1	GO:0071008	U2-type post-mRNA release spliceosomal complex(GO:0071008)
0.0	0.1	GO:0032444	activin responsive factor complex(GO:0032444)
0.0	0.2	GO:0045180	basal cortex(GO:0045180)
0.0	0.2	GO:0097433	dense body(GO:0097433)
0.0	0.2	GO:0097524	sperm plasma membrane(GO:0097524)
0.0	0.0	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.1	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.2	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.2	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.0	0.3	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0033647	host intracellular organelle(GO:0033647) host intracellular membrane-bounded organelle(GO:0033648)
0.0	0.2	GO:0045275	mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.0	0.2	GO:0032300	mismatch repair complex(GO:0032300)
0.0	0.3	GO:0032426	stereocilium tip(GO:0032426)
0.0	0.1	GO:0044354	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.1	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0	0.1	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.0	0.2	GO:0090571	RNA polymerase II transcription repressor complex(GO:0090571)
0.0	0.6	GO:0005790	smooth endoplasmic reticulum(GO:0005790)
0.0	0.1	GO:0035749	myelin sheath adaxonal region(GO:0035749)
0.0	0.1	GO:0005610	laminin-5 complex(GO:0005610)
0.0	0.1	GO:0070847	core mediator complex(GO:0070847)
0.0	0.1	GO:0000110	nucleotide-excision repair factor 1 complex(GO:0000110)
0.0	0.1	GO:0001940	male pronucleus(GO:0001940)
0.0	0.1	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.2	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.4	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0033180	proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.1	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.1	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.1	GO:0000322	storage vacuole(GO:0000322)
0.0	0.1	GO:0000172	ribonuclease MRP complex(GO:0000172)
0.0	0.1	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.2	GO:0030877	beta-catenin destruction complex(GO:0030877)
0.0	0.3	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.1	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.0	0.1	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.1	GO:0043293	apoptosome(GO:0043293)
0.0	0.2	GO:0005675	holo TFIIH complex(GO:0005675)
0.0	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.1	GO:0000938	GARP complex(GO:0000938)
0.0	0.1	GO:0031467	Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0	0.1	GO:0070652	HAUS complex(GO:0070652)
0.0	0.0	GO:0032299	ribonuclease H2 complex(GO:0032299)
0.0	0.0	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.1	GO:0035339	SPOTS complex(GO:0035339)
0.0	0.3	GO:0000242	pericentriolar material(GO:0000242)
0.0	0.0	GO:0001939	female pronucleus(GO:0001939)
0.0	0.0	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.0	GO:0044614	nuclear pore cytoplasmic filaments(GO:0044614)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0070852	cell body fiber(GO:0070852)
0.0	0.0	GO:0097452	GAIT complex(GO:0097452)
0.0	0.1	GO:0097651	phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0	0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	0.7	GO:0005811	lipid particle(GO:0005811)
0.0	0.1	GO:0005942	phosphatidylinositol 3-kinase complex(GO:0005942)
0.0	0.2	GO:0000159	protein phosphatase type 2A complex(GO:0000159)
0.0	0.1	GO:0031080	nuclear pore outer ring(GO:0031080)
0.0	0.1	GO:0031502	dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.0	0.1	GO:0035253	ciliary rootlet(GO:0035253)
0.0	0.1	GO:0044666	MLL3/4 complex(GO:0044666)
0.0	0.1	GO:0034464	BBSome(GO:0034464)
0.0	0.0	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.2	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.0	0.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.4	GO:0008023	transcription elongation factor complex(GO:0008023)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0008278	cohesin complex(GO:0008278)
0.0	0.2	GO:0005680	anaphase-promoting complex(GO:0005680)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.0	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:0005638	lamin filament(GO:0005638)
0.0	0.0	GO:0045298	tubulin complex(GO:0045298)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.1	0.3	GO:0032139	dinucleotide insertion or deletion binding(GO:0032139)
0.1	0.8	GO:0004312	fatty acid synthase activity(GO:0004312)
0.1	0.2	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1	0.2	GO:0004711	ribosomal protein S6 kinase activity(GO:0004711)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.1	GO:1990825	sequence-specific mRNA binding(GO:1990825)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.2	GO:0000405	bubble DNA binding(GO:0000405)
0.0	0.1	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.0	0.2	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0015143	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.0	0.1	GO:0000386	second spliceosomal transesterification activity(GO:0000386)
0.0	0.1	GO:0035663	Toll-like receptor 2 binding(GO:0035663)
0.0	0.1	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0004771	sterol esterase activity(GO:0004771)
0.0	0.4	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.1	GO:0032564	dATP binding(GO:0032564)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0003829	beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.0	0.2	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0070052	collagen V binding(GO:0070052)
0.0	0.2	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.1	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.1	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.1	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.0	GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679)
0.0	0.2	GO:0031685	adenosine receptor binding(GO:0031685)
0.0	0.1	GO:0047192	1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192)
0.0	0.1	GO:0004949	cannabinoid receptor activity(GO:0004949)
0.0	0.2	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.2	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.1	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0070573	metallodipeptidase activity(GO:0070573)
0.0	0.1	GO:0016647	oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0	0.1	GO:0004814	arginine-tRNA ligase activity(GO:0004814)
0.0	0.1	GO:1901612	cardiolipin binding(GO:1901612)
0.0	0.3	GO:0051010	microtubule plus-end binding(GO:0051010)
0.0	0.1	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.4	GO:0016594	glycine binding(GO:0016594)
0.0	0.3	GO:0051787	misfolded protein binding(GO:0051787)
0.0	0.1	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
0.0	0.1	GO:0003846	2-acylglycerol O-acyltransferase activity(GO:0003846)
0.0	0.2	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.4	GO:0008607	phosphorylase kinase regulator activity(GO:0008607)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.2	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.1	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.1	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.2	GO:0030346	protein phosphatase 2B binding(GO:0030346)
0.0	0.1	GO:0031802	type 5 metabotropic glutamate receptor binding(GO:0031802)
0.0	0.1	GO:0019002	GMP binding(GO:0019002)
0.0	0.2	GO:0030306	ADP-ribosylation factor binding(GO:0030306)
0.0	0.1	GO:0008073	ornithine decarboxylase inhibitor activity(GO:0008073)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.1	GO:0047045	testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.1	GO:0001226	RNA polymerase II transcription corepressor binding(GO:0001226)
0.0	0.1	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0035515	oxidative RNA demethylase activity(GO:0035515)
0.0	0.0	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.2	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.1	GO:0004994	somatostatin receptor activity(GO:0004994)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.1	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	0.2	GO:0016861	intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.2	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0005042	netrin receptor activity(GO:0005042)
0.0	0.1	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.0	0.1	GO:0019153	protein-disulfide reductase (glutathione) activity(GO:0019153)
0.0	0.2	GO:0001223	transcription coactivator binding(GO:0001223)
0.0	0.1	GO:0004813	alanine-tRNA ligase activity(GO:0004813)
0.0	0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.1	GO:0086008	voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.2	GO:0032041	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.0	0.1	GO:0044020	histone methyltransferase activity (H4-R3 specific)(GO:0044020)
0.0	0.2	GO:0016832	aldehyde-lyase activity(GO:0016832)
0.0	0.1	GO:0000171	ribonuclease MRP activity(GO:0000171)
0.0	0.3	GO:0004089	carbonate dehydratase activity(GO:0004089)
0.0	0.1	GO:0097001	ceramide binding(GO:0097001)
0.0	0.1	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0003917	DNA topoisomerase type I activity(GO:0003917)
0.0	0.1	GO:0004985	opioid receptor activity(GO:0004985)
0.0	0.1	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.0	GO:0071532	ankyrin repeat binding(GO:0071532)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.1	GO:0070191	methionine-R-sulfoxide reductase activity(GO:0070191)
0.0	0.1	GO:0016909	JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.0	0.1	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0015057	thrombin receptor activity(GO:0015057)
0.0	0.2	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.1	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.0	0.2	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.0	GO:0018594	fluorene oxygenase activity(GO:0018585) mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.0	0.1	GO:0046624	sphingolipid transporter activity(GO:0046624)
0.0	0.1	GO:0004534	5'-3' exoribonuclease activity(GO:0004534)
0.0	0.1	GO:0061665	SUMO ligase activity(GO:0061665)
0.0	0.1	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.0	GO:0004938	alpha2-adrenergic receptor activity(GO:0004938)
0.0	0.1	GO:0004430	1-phosphatidylinositol 4-kinase activity(GO:0004430)
0.0	0.1	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.1	GO:0005280	hydrogen:amino acid symporter activity(GO:0005280)
0.0	0.1	GO:0017169	CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0	0.1	GO:0000268	peroxisome targeting sequence binding(GO:0000268)
0.0	0.2	GO:0004787	thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.0	0.0	GO:0015216	adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346) purine nucleotide transmembrane transporter activity(GO:0015216)
0.0	0.3	GO:0005112	Notch binding(GO:0005112)
0.0	0.0	GO:0031871	proteinase activated receptor binding(GO:0031871)
0.0	0.1	GO:0015215	nucleotide transmembrane transporter activity(GO:0015215)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.0	GO:0051379	epinephrine binding(GO:0051379)
0.0	0.0	GO:0032558	adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.1	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656)
0.0	0.1	GO:0003997	acyl-CoA oxidase activity(GO:0003997)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.0	GO:0070139	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.2	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.0	0.0	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0031386	protein tag(GO:0031386)
0.0	0.1	GO:0034236	protein kinase A catalytic subunit binding(GO:0034236)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.0	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.1	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0050051	leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.4	GO:0051723	protein methylesterase activity(GO:0051723)
0.0	0.3	GO:0050681	androgen receptor binding(GO:0050681)
0.0	0.2	GO:0008601	protein phosphatase type 2A regulator activity(GO:0008601)
0.0	0.1	GO:0035613	RNA stem-loop binding(GO:0035613)
0.0	0.0	GO:0016842	amidine-lyase activity(GO:0016842)
0.0	0.0	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.0	0.2	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.0	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0	0.1	GO:0017040	ceramidase activity(GO:0017040)
0.0	0.0	GO:0004477	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0	0.1	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.0	GO:0017150	tRNA dihydrouridine synthase activity(GO:0017150)
0.0	0.0	GO:0016880	acid-ammonia (or amide) ligase activity(GO:0016880)
0.0	0.2	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.0	GO:0098821	BMP receptor activity(GO:0098821)
0.0	0.1	GO:0052813	phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813)
0.0	0.1	GO:0000014	single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0	0.1	GO:0071933	Arp2/3 complex binding(GO:0071933)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.0	GO:0000155	phosphorelay sensor kinase activity(GO:0000155)
0.0	0.1	GO:0004758	serine C-palmitoyltransferase activity(GO:0004758)
0.0	0.1	GO:0016595	glutamate binding(GO:0016595)
0.0	0.0	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.0	GO:0004719	protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719)
0.0	0.2	GO:0008252	nucleotidase activity(GO:0008252)
0.0	0.1	GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0	0.0	GO:0071253	connexin binding(GO:0071253)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.0	GO:0008506	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.0	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.3	GO:0004117	calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117) cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118) cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) photoreceptor cyclic-nucleotide phosphodiesterase activity(GO:0004120) 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity(GO:0044688) inositol phosphosphingolipid phospholipase activity(GO:0052712) inositol phosphorylceramide phospholipase activity(GO:0052713) mannosyl-inositol phosphorylceramide phospholipase activity(GO:0052714) mannosyl-diinositol phosphorylceramide phospholipase activity(GO:0052715)
0.0	0.0	GO:0016532	superoxide dismutase copper chaperone activity(GO:0016532)
0.0	0.1	GO:0052723	inositol hexakisphosphate kinase activity(GO:0000828) inositol hexakisphosphate 5-kinase activity(GO:0000832) inositol hexakisphosphate 1-kinase activity(GO:0052723) inositol hexakisphosphate 3-kinase activity(GO:0052724)
0.0	0.0	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0	0.0	GO:0035662	Toll-like receptor 4 binding(GO:0035662)
0.0	0.0	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.3	GO:0005246	calcium channel regulator activity(GO:0005246)
0.0	0.0	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.1	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.0	GO:0016149	translation release factor activity, codon specific(GO:0016149)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID FAK PATHWAY	Signaling events mediated by focal adhesion kinase
0.4	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
1.3	PID P73PATHWAY	p73 transcription factor network
0.2	SA PTEN PATHWAY	PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.2	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.2	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.0	PID S1P S1P4 PATHWAY	S1P4 pathway
0.3	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.3	PID BARD1 PATHWAY	BARD1 signaling events
0.3	PID AURORA A PATHWAY	Aurora A signaling
0.0	PID ALK1 PATHWAY	ALK1 signaling events
0.4	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.3	PID AR NONGENOMIC PATHWAY	Nongenotropic Androgen signaling
0.2	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.1	PID S1P S1P2 PATHWAY	S1P2 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.7	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism
0.0	0.3	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.3	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.1	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	0.3	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.4	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.0	0.2	REACTOME IRAK1 RECRUITS IKK COMPLEX	Genes involved in IRAK1 recruits IKK complex
0.0	0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.3	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.0	0.2	REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE	Genes involved in Synthesis of PIPs at the early endosome membrane
0.0	0.1	REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS	Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0	0.2	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.3	REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY	Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.0	0.4	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.2	REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND	Genes involved in Removal of the Flap Intermediate from the C-strand
0.0	0.3	REACTOME FORMATION OF INCISION COMPLEX IN GG NER	Genes involved in Formation of incision complex in GG-NER
0.0	0.2	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
0.0	0.2	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.0	0.3	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.2	REACTOME TRANSCRIPTIONAL ACTIVITY OF SMAD2 SMAD3 SMAD4 HETEROTRIMER	Genes involved in Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
0.0	0.1	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.2	REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A	Genes involved in APC-Cdc20 mediated degradation of Nek2A
0.0	0.1	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	0.0	REACTOME NOD1 2 SIGNALING PATHWAY	Genes involved in NOD1/2 Signaling Pathway
0.0	0.2	REACTOME REGULATION OF SIGNALING BY CBL	Genes involved in Regulation of signaling by CBL
0.0	0.0	REACTOME MITOTIC M M G1 PHASES	Genes involved in Mitotic M-M/G1 phases
0.0	0.0	REACTOME ARMS MEDIATED ACTIVATION	Genes involved in ARMS-mediated activation
0.0	0.3	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0	0.5	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.0	0.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.0	0.2	REACTOME SYNTHESIS OF PC	Genes involved in Synthesis of PC
0.0	0.1	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.0	0.1	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis

Results for Nkx2-5

Z-value: 1.40

Motif logo

Transcription factors associated with Nkx2-5

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Nkx2-5 motif across conditions

Conditions sorted by the z-value of the Nkx2-5 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: