Project

ENCSR904DTN: DNase-seq of mouse liver in constant darkness

Navigation

Downloads

Results for Nkx2-6

Z-value: 1.04

Motif logo

Transcription factors associated with Nkx2-6

Gene Symbol	Gene ID	Gene Info
Nkx2-6 Ensembl NCBI MGI UniProt	ENSMUSG00000044186.9	NK2 homeobox 6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr14_69171500_69171815	Nkx2-6	145	0.567867	-0.35	4.9e-01	Click!

Activity of the Nkx2-6 motif across conditions

Conditions sorted by the z-value of the Nkx2-6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_52319247_52319421	1.36	Neb	nebulin	15800	0.17
chr13_41019879_41020036	1.07	Tmem14c	transmembrane protein 14C	3665	0.15
chr7_126636776_126636927	0.84	Nupr1	nuclear protein transcription regulator 1	5990	0.08
chr3_144617682_144617841	0.71	Rpl9-ps8	ribosomal protein L9, pseudogene 8	8203	0.15
chr1_187214930_187215194	0.71	Spata17	spermatogenesis associated 17	359	0.55
chr17_42900854_42901005	0.65	Cd2ap	CD2-associated protein	24264	0.24
chr9_56260139_56260312	0.64	Peak1os	pseudopodium-enriched atypical kinase 1, opposite strand	2335	0.21
chr11_16588986_16589143	0.59	Gm12663	predicted gene 12663	47002	0.12
chr11_32659387_32659538	0.56	Fbxw11	F-box and WD-40 domain protein 11	16558	0.21
chr5_32328252_32328418	0.56	Gm15615	predicted gene 15615	16216	0.14
chr2_148236402_148236558	0.53	Gm24221	predicted gene, 24221	85330	0.08
chr3_68508770_68508933	0.52	Schip1	schwannomin interacting protein 1	14643	0.22
chr19_45958655_45958833	0.52	Armh3	armadillo-like helical domain containing 3	22315	0.13
chr2_35496007_35496180	0.49	Gm13445	predicted gene 13445	4574	0.15
chr16_72452183_72452361	0.47	Gm49670	predicted gene, 49670	79831	0.11
chr2_91216142_91216316	0.44	Acp2	acid phosphatase 2, lysosomal	13301	0.09
chr15_3380372_3380645	0.43	Ccdc152	coiled-coil domain containing 152	76982	0.1
chr15_75111208_75111372	0.43	Ly6c2	lymphocyte antigen 6 complex, locus C2	407	0.75
chr9_25525770_25525922	0.42	Gm25861	predicted gene, 25861	13359	0.19
chr8_114151087_114151399	0.41	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	17601	0.25
chr14_26156193_26156349	0.41	Gm2274	predicted gene 2274	235	0.89
chr12_59040509_59040699	0.40	Gm22973	predicted gene, 22973	269	0.85
chr11_90224957_90225225	0.40	Mmd	monocyte to macrophage differentiation-associated	24365	0.15
chr7_68280697_68280888	0.39	Gm16157	predicted gene 16157	4198	0.16
chr14_25876809_25876970	0.39	Anxa11os	annexin A11, opposite strand	6623	0.13
chr14_26016579_26016740	0.39	Gm2260	predicted gene 2260	228	0.89
chr6_121146935_121147121	0.38	Mical3	microtubule associated monooxygenase, calponin and LIM domain containing 3	16029	0.13
chr5_129974617_129974800	0.37	Vkorc1l1	vitamin K epoxide reductase complex, subunit 1-like 1	2286	0.18
chr11_16874843_16874994	0.37	Egfr	epidermal growth factor receptor	3232	0.26
chr15_59391938_59392317	0.36	Nsmce2	NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase	17840	0.18
chr12_71863911_71864079	0.35	Gm7985	predicted gene 7985	16704	0.2
chr11_69554847_69555031	0.35	Efnb3	ephrin B3	5266	0.08
chr7_123369817_123370115	0.34	Arhgap17	Rho GTPase activating protein 17	51	0.68
chr13_113901345_113901524	0.34	Arl15	ADP-ribosylation factor-like 15	106812	0.06
chr8_84698956_84699121	0.33	Trmt1	tRNA methyltransferase 1	33	0.95
chr5_122602369_122602541	0.33	Ift81	intraflagellar transport 81	1038	0.42
chr6_29658788_29659068	0.33	Tspan33	tetraspanin 33	35294	0.13
chr9_74793041_74793363	0.32	Gm22315	predicted gene, 22315	11132	0.18
chr8_77961865_77962061	0.31	Gm29895	predicted gene, 29895	82047	0.09
chr15_93744270_93744427	0.31	Gm30339	predicted gene, 30339	9935	0.21
chr2_20909493_20909665	0.31	Arhgap21	Rho GTPase activating protein 21	5115	0.23
chr11_22880864_22881030	0.31	Gm24917	predicted gene, 24917	12046	0.12
chr15_62712455_62712777	0.31	Gm24810	predicted gene, 24810	59612	0.14
chr16_22398929_22399080	0.30	Etv5	ets variant 5	2825	0.28
chr17_28982482_28982633	0.30	Stk38	serine/threonine kinase 38	371	0.72
chr6_53995717_53996030	0.30	4921529L05Rik	RIKEN cDNA 4921529L05 gene	13839	0.18
chr3_156794209_156794402	0.29	Gm15578	predicted gene 15578	21732	0.19
chr8_53780941_53781092	0.29	Gm19921	predicted gene, 19921	130723	0.05
chr7_14430188_14430339	0.29	Sult2a8	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8	6184	0.17
chr13_45960108_45960603	0.29	Atxn1	ataxin 1	4602	0.21
chr13_17717656_17717837	0.28	Gm48621	predicted gene, 48621	7882	0.12
chr13_28738845_28739011	0.28	Mir6368	microRNA 6368	28055	0.21
chr3_18131799_18132081	0.27	Gm23686	predicted gene, 23686	45685	0.14
chr6_92468512_92468696	0.27	Prickle2	prickle planar cell polarity protein 2	12788	0.26
chr2_69137808_69137978	0.27	Nostrin	nitric oxide synthase trafficker	2093	0.33
chr8_48730833_48730999	0.27	Tenm3	teneurin transmembrane protein 3	56226	0.15
chr5_139871644_139871802	0.27	Gm42423	predicted gene 42423	24086	0.12
chr1_85592768_85593352	0.26	Sp110	Sp110 nuclear body protein	3869	0.12
chr8_56313612_56313880	0.26	Gm45540	predicted gene 45540	2442	0.34
chr10_84063624_84063775	0.25	Gm37908	predicted gene, 37908	1941	0.33
chr5_33725824_33725998	0.25	Fgfr3	fibroblast growth factor receptor 3	2139	0.17
chr6_31115031_31115198	0.25	5330406M23Rik	RIKEN cDNA 5330406M23 gene	4194	0.14
chr10_25432440_25432591	0.25	Epb41l2	erythrocyte membrane protein band 4.1 like 2	84	0.97
chr15_31357037_31357188	0.24	Ankrd33b	ankyrin repeat domain 33B	10420	0.16
chr3_8924868_8925019	0.24	Mrps28	mitochondrial ribosomal protein S28	1025	0.53
chr1_23484714_23484885	0.23	Gm7784	predicted gene 7784	5260	0.27
chr19_21919071_21919233	0.23	Ldhb-ps	lactate dehydrogenase B, pseudogene	18228	0.18
chr12_105034220_105034389	0.23	Glrx5	glutaredoxin 5	912	0.35
chr5_144248287_144248466	0.23	2900089D17Rik	RIKEN cDNA 2900089D17 gene	1870	0.23
chr6_28554965_28555164	0.23	Snd1	staphylococcal nuclease and tudor domain containing 1	6753	0.17
chr13_68578198_68578368	0.23	Mtrr	5-methyltetrahydrofolate-homocysteine methyltransferase reductase	3611	0.19
chr19_9027860_9028087	0.23	Ahnak	AHNAK nucleoprotein (desmoyokin)	28313	0.09
chr1_168502271_168502436	0.23	Mir6348	microRNA 6348	11710	0.27
chr3_69778568_69778734	0.22	Nmd3	NMD3 ribosome export adaptor	32219	0.16
chr13_110882966_110883130	0.22	Gm38397	predicted gene, 38397	20451	0.14
chr8_33981301_33981581	0.22	Gm39157	predicted gene, 39157	4473	0.18
chr10_111676325_111676608	0.22	Gm47864	predicted gene, 47864	26654	0.15
chr10_68137101_68137496	0.22	Arid5b	AT rich interactive domain 5B (MRF1-like)	672	0.78
chr1_60824712_60825126	0.21	Gm11581	predicted gene 11581	15803	0.12
chr3_98056406_98056789	0.21	Gm42819	predicted gene 42819	25910	0.16
chr5_110802281_110802488	0.20	Ulk1	unc-51 like kinase 1	6550	0.11
chr16_87690191_87690394	0.20	Bach1	BTB and CNC homology 1, basic leucine zipper transcription factor 1	8653	0.22
chr16_52322703_52322854	0.20	Alcam	activated leukocyte cell adhesion molecule	25854	0.26
chr9_40773794_40774087	0.20	Clmp	CXADR-like membrane protein	154	0.91
chr3_79587078_79587240	0.20	Ppid	peptidylprolyl isomerase D (cyclophilin D)	4183	0.13
chr16_11638892_11639072	0.20	Gm4279	predicted gene 4279	52875	0.15
chr4_49536222_49536402	0.20	Aldob	aldolase B, fructose-bisphosphate	2554	0.2
chr16_30664084_30664254	0.20	Fam43a	family with sequence similarity 43, member A	64446	0.1
chr1_133493056_133493228	0.20	Gm8596	predicted gene 8596	36337	0.14
chr7_119668193_119668569	0.20	Acsm4	acyl-CoA synthetase medium-chain family member 4	21645	0.1
chr17_72933196_72933347	0.20	Lbh	limb-bud and heart	12083	0.23
chr8_36692402_36692571	0.19	Dlc1	deleted in liver cancer 1	40568	0.2
chr6_87552153_87552313	0.19	Gm44198	predicted gene, 44198	18826	0.13
chr17_53565206_53565384	0.19	Kat2b	K(lysine) acetyltransferase 2B	1566	0.33
chr10_99384294_99384806	0.19	B530045E10Rik	RIKEN cDNA B530045E10 gene	18240	0.17
chr4_40156775_40156949	0.19	Aco1	aconitase 1	6857	0.2
chr17_69396159_69396341	0.19	Gm49894	predicted gene, 49894	12042	0.14
chr9_21692583_21692969	0.19	Gm26511	predicted gene, 26511	30674	0.1
chr10_128231734_128232048	0.19	Timeless	timeless circadian clock 1	174	0.87
chr7_19668878_19669149	0.18	Clptm1	cleft lip and palate associated transmembrane protein 1	3980	0.09
chr2_79977386_79977747	0.18	Pde1a	phosphodiesterase 1A, calmodulin-dependent	49775	0.17
chr13_52037190_52037541	0.18	Gm37872	predicted gene, 37872	15438	0.21
chr5_137054912_137055067	0.18	Ap1s1	adaptor protein complex AP-1, sigma 1	8854	0.1
chr3_67677368_67677587	0.18	Gm37601	predicted gene, 37601	7275	0.2
chr16_91765796_91766068	0.18	Itsn1	intersectin 1 (SH3 domain protein 1A)	9833	0.16
chr15_69043517_69043680	0.18	Gm49422	predicted gene, 49422	84067	0.09
chr7_73430637_73430788	0.18	Gm44645	predicted gene 44645	8462	0.12
chr10_80050367_80050530	0.18	Gpx4	glutathione peroxidase 4	3040	0.12
chr19_55276564_55276746	0.18	Acsl5	acyl-CoA synthetase long-chain family member 5	3785	0.21
chr11_75750659_75750835	0.17	Ywhae	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide	857	0.56
chr6_37473792_37473962	0.17	Creb3l2	cAMP responsive element binding protein 3-like 2	31731	0.19
chr5_148740765_148741271	0.17	2210417A02Rik	RIKEN cDNA 2210417A02 gene	822	0.56
chr1_62730735_62730912	0.17	Gm29083	predicted gene 29083	12750	0.18
chr3_109255070_109255263	0.17	Gm13865	predicted gene 13865	62299	0.11
chr4_62696097_62696258	0.17	Rgs3	regulator of G-protein signaling 3	3289	0.21
chr4_136501510_136501674	0.17	Luzp1	leucine zipper protein 1	19803	0.14
chr14_54653654_54653818	0.17	Acin1	apoptotic chromatin condensation inducer 1	35	0.93
chr11_51753632_51753825	0.17	Sec24a	Sec24 related gene family, member A (S. cerevisiae)	2483	0.22
chr1_138992310_138992466	0.17	Gm16305	predicted gene 16305	319	0.81
chr14_117130450_117130601	0.17	Gpc6	glypican 6	204589	0.03
chr5_119675143_119675355	0.17	Tbx3	T-box 3	196	0.92
chr5_51552225_51552395	0.17	Ppargc1a	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	1561	0.41
chr14_62878202_62878375	0.17	n-R5s47	nuclear encoded rRNA 5S 47	8574	0.14
chr6_21827909_21828060	0.17	Tspan12	tetraspanin 12	23844	0.17
chr4_128840401_128840595	0.16	Gm12968	predicted gene 12968	5699	0.17
chr15_57913180_57913355	0.16	Tbc1d31	TBC1 domain family, member 31	262	0.92
chr1_170640374_170640534	0.16	Olfml2b	olfactomedin-like 2B	4078	0.21
chr3_97076104_97076274	0.16	4930573H18Rik	RIKEN cDNA 4930573H18 gene	16596	0.15
chr10_20005611_20005762	0.16	Map3k5	mitogen-activated protein kinase kinase kinase 5	54631	0.13
chr15_9596764_9597341	0.16	Il7r	interleukin 7 receptor	66876	0.12
chr15_75048041_75048215	0.16	Ly6c1	lymphocyte antigen 6 complex, locus C1	541	0.61
chr18_16753631_16753792	0.16	Gm15485	predicted gene 15485	24978	0.2
chr1_77213552_77213762	0.15	Gm38265	predicted gene, 38265	66665	0.12
chr14_63150536_63150699	0.15	Fdft1	farnesyl diphosphate farnesyl transferase 1	14308	0.13
chr3_7648648_7649046	0.15	Il7	interleukin 7	35087	0.17
chr15_58977395_58977546	0.15	Mtss1	MTSS I-BAR domain containing 1	4931	0.17
chr7_80741087_80741271	0.15	Iqgap1	IQ motif containing GTPase activating protein 1	2701	0.24
chr4_139631247_139631408	0.15	Aldh4a1	aldehyde dehydrogenase 4 family, member A1	8218	0.14
chr2_53063355_53063523	0.15	Prpf40a	pre-mRNA processing factor 40A	81870	0.1
chr7_65338015_65338188	0.15	Tjp1	tight junction protein 1	4696	0.24
chr4_97752078_97752249	0.15	Gm12676	predicted gene 12676	5226	0.23
chr9_97490330_97490709	0.15	Gm25607	predicted gene, 25607	50892	0.16
chr7_16583531_16584108	0.15	Gm29443	predicted gene 29443	30005	0.08
chr8_61132865_61133032	0.15	Gm16179	predicted gene 16179	20446	0.16
chr3_89113148_89113310	0.15	Gm29704	predicted gene, 29704	3495	0.09
chr6_58832580_58832969	0.15	Herc3	hect domain and RLD 3	913	0.62
chr1_107942021_107942201	0.15	D830032E09Rik	RIKEN cDNA D830032E09 gene	5402	0.2
chr12_73715979_73716146	0.15	Prkch	protein kinase C, eta	67141	0.1
chr6_99656184_99656335	0.14	Gm44104	predicted gene, 44104	5959	0.16
chr6_124509130_124509281	0.14	C1ra	complement component 1, r subcomponent A	3200	0.12
chr5_115530819_115531136	0.14	Pxn	paxillin	10672	0.09
chr8_46540344_46540495	0.14	Acsl1	acyl-CoA synthetase long-chain family member 1	9355	0.15
chr18_36661287_36661681	0.14	Eif4ebp3	eukaryotic translation initiation factor 4E binding protein 3	2576	0.13
chr10_83637415_83637787	0.14	Appl2	adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2	158	0.96
chr9_119309190_119309381	0.14	Gm22729	predicted gene, 22729	2528	0.19
chr17_86911957_86912124	0.14	Tmem247	transmembrane protein 247	5308	0.16
chr5_113133182_113133354	0.14	2900026A02Rik	RIKEN cDNA 2900026A02 gene	4718	0.12
chr17_43105938_43106161	0.14	E130008D07Rik	RIKEN cDNA E130008D07 gene	52147	0.16
chr9_120048495_120048762	0.13	Cx3cr1	chemokine (C-X3-C motif) receptor 1	19655	0.08
chr19_8966037_8966203	0.13	Eef1g	eukaryotic translation elongation factor 1 gamma	921	0.31
chr6_72416544_72416700	0.13	Ggcx	gamma-glutamyl carboxylase	1233	0.31
chr5_133173380_133173603	0.13	Gm42625	predicted gene 42625	269851	0.02
chr19_10268064_10268219	0.13	Dagla	diacylglycerol lipase, alpha	11270	0.13
chr16_44063056_44063226	0.13	Gramd1c	GRAM domain containing 1C	184	0.95
chr5_117979355_117979506	0.13	Fbxo21	F-box protein 21	106	0.95
chr13_50051310_50051474	0.13	Gm48052	predicted gene, 48052	387	0.79
chr5_99388868_99389019	0.13	Gm35394	predicted gene, 35394	114848	0.05
chr11_98874019_98874180	0.13	Gm23640	predicted gene, 23640	3600	0.13
chr15_96708796_96708976	0.13	Gm38144	predicted gene, 38144	8713	0.18
chr5_77100130_77100295	0.13	Hopx	HOP homeobox	4935	0.14
chr13_16715662_16715832	0.13	Gm7537	predicted gene 7537	76257	0.11
chr12_72047672_72047836	0.13	Gm7986	predicted gene 7986	1505	0.36
chr7_126109278_126109457	0.13	Xpo6	exportin 6	684	0.65
chr1_133921507_133921777	0.13	Prelp	proline arginine-rich end leucine-rich repeat	228	0.9
chr16_35309712_35309912	0.13	Gm49706	predicted gene, 49706	13254	0.15
chr3_89770512_89770671	0.12	4632404H12Rik	RIKEN cDNA 4632404H12 gene	2200	0.18
chr11_35007192_35007387	0.12	Gm25799	predicted gene, 25799	108272	0.06
chr6_100185590_100185876	0.12	2010109P13Rik	RIKEN cDNA 2010109P13 gene	41919	0.13
chr14_27338148_27338304	0.12	Arhgef3	Rho guanine nucleotide exchange factor (GEF) 3	2160	0.35
chr19_44064101_44064296	0.12	Erlin1	ER lipid raft associated 1	3485	0.17
chr10_8830122_8830414	0.12	Gm25410	predicted gene, 25410	6121	0.2
chr5_140644827_140644989	0.12	Ttyh3	tweety family member 3	4089	0.17
chr17_65784660_65784842	0.12	Ppp4r1	protein phosphatase 4, regulatory subunit 1	1152	0.47
chr11_84199091_84199285	0.12	Acaca	acetyl-Coenzyme A carboxylase alpha	3750	0.22
chr1_48351528_48351702	0.12	Gm5974	predicted gene 5974	36764	0.22
chrX_11130477_11130658	0.12	Gm14481	predicted gene 14481	90040	0.07
chr7_80445419_80445914	0.12	Blm	Bloom syndrome, RecQ like helicase	11706	0.12
chr19_6390399_6390550	0.12	Pygm	muscle glycogen phosphorylase	2237	0.14
chr5_144904863_144905014	0.12	Smurf1	SMAD specific E3 ubiquitin protein ligase 1	6944	0.16
chr16_25011043_25011318	0.11	A230028O05Rik	RIKEN cDNA A230028O05 gene	48459	0.18
chr1_164703629_164703781	0.11	Gm37853	predicted gene, 37853	5472	0.17
chr5_34408526_34408716	0.11	Fam193a	family with sequence homology 193, member A	17716	0.13
chr1_161253186_161253391	0.11	Prdx6	peroxiredoxin 6	2069	0.29
chr6_119352807_119352958	0.11	Cacna2d4	calcium channel, voltage-dependent, alpha 2/delta subunit 4	20320	0.17
chr8_56292788_56292973	0.11	Hpgd	hydroxyprostaglandin dehydrogenase 15 (NAD)	1705	0.43
chr1_39372307_39372514	0.11	Tbc1d8	TBC1 domain family, member 8	23	0.97
chr13_81328551_81328735	0.11	Adgrv1	adhesion G protein-coupled receptor V1	14193	0.26
chr17_29579809_29579984	0.11	Tbc1d22b	TBC1 domain family, member 22B	7473	0.09
chr4_100914770_100914929	0.11	Cachd1	cache domain containing 1	79762	0.09
chr6_92219535_92219693	0.11	Rbsn	rabenosyn, RAB effector	4689	0.17

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-6

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0032911	negative regulation of transforming growth factor beta1 production(GO:0032911)
0.1	0.2	GO:0010159	specification of organ position(GO:0010159)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.2	GO:0030263	apoptotic chromosome condensation(GO:0030263)
0.0	0.1	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0	0.1	GO:0070779	D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
0.0	0.1	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	0.1	GO:0034093	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.1	GO:0097252	oligodendrocyte apoptotic process(GO:0097252)
0.0	0.3	GO:0030488	tRNA methylation(GO:0030488)
0.0	0.1	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0	0.1	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0098728	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.0	GO:0036394	amylase secretion(GO:0036394)
0.0	0.1	GO:0090168	Golgi reassembly(GO:0090168)
0.0	0.1	GO:0014835	myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.0	0.0	GO:0006001	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.0	GO:0030397	membrane disassembly(GO:0030397) nuclear envelope disassembly(GO:0051081)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:0090043	regulation of tubulin deacetylation(GO:0090043)
0.0	0.1	GO:0018076	N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0	0.0	GO:1903774	positive regulation of viral budding via host ESCRT complex(GO:1903774)
0.0	0.1	GO:0048550	negative regulation of pinocytosis(GO:0048550)
0.0	0.0	GO:0061144	alveolar secondary septum development(GO:0061144)
0.0	0.2	GO:0008210	estrogen metabolic process(GO:0008210)
0.0	0.0	GO:0033353	S-adenosylmethionine cycle(GO:0033353)
0.0	0.0	GO:1990791	dorsal root ganglion development(GO:1990791)
0.0	0.0	GO:1903525	regulation of membrane tubulation(GO:1903525)
0.0	0.3	GO:0030866	cortical actin cytoskeleton organization(GO:0030866)
0.0	0.0	GO:0000393	spliceosomal conformational changes to generate catalytic conformation(GO:0000393)
0.0	0.0	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.0	GO:0036438	maintenance of lens transparency(GO:0036438)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.2	GO:0061574	ASAP complex(GO:0061574)
0.2	GO:0070688	MLL5-L complex(GO:0070688)
0.1	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.0	GO:0031084	BLOC-2 complex(GO:0031084)
0.1	GO:0097542	ciliary tip(GO:0097542)
0.0	GO:0097425	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
0.1	GO:0030915	Smc5-Smc6 complex(GO:0030915)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0042731	PH domain binding(GO:0042731)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0047276	N-acetyllactosaminide 3-alpha-galactosyltransferase activity(GO:0047276)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.1	GO:0004957	prostaglandin E receptor activity(GO:0004957)
0.0	0.0	GO:0004920	interleukin-10 receptor activity(GO:0004920)
0.0	0.2	GO:0005172	vascular endothelial growth factor receptor binding(GO:0005172)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.0	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.0	GO:0004082	bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
0.0	0.1	GO:0004468	lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.0	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0032552	deoxyribonucleotide binding(GO:0032552)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.0	GO:0008184	glycogen phosphorylase activity(GO:0008184)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.0	0.2	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.1	REACTOME KERATAN SULFATE DEGRADATION	Genes involved in Keratan sulfate degradation
0.0	0.0	REACTOME CTLA4 INHIBITORY SIGNALING	Genes involved in CTLA4 inhibitory signaling

Results for Nkx2-6

Z-value: 1.04

Motif logo

Transcription factors associated with Nkx2-6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Nkx2-6 motif across conditions

Conditions sorted by the z-value of the Nkx2-6 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx2-6

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: