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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Nkx6-3_Dbx2_Barx2

Z-value: 1.10

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Transcription factors associated with Nkx6-3_Dbx2_Barx2

Gene Symbol	Gene ID	Gene Info
Nkx6-3 Ensembl NCBI MGI UniProt	ENSMUSG00000063672.6	Nkx6-3
Dbx2 Ensembl NCBI MGI UniProt	ENSMUSG00000045608.6	Dbx2
Barx2 Ensembl NCBI MGI UniProt	ENSMUSG00000032033.10	Barx2

Activity of the Nkx6-3_Dbx2_Barx2 motif across conditions

Conditions sorted by the z-value of the Nkx6-3_Dbx2_Barx2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr2_134708873_134709037	1.91	Gm14037	predicted gene 14037	22152	0.2
chr11_16883025_16883203	1.80	Egfr	epidermal growth factor receptor	4964	0.23
chr2_107628721_107628872	1.43	Gm9864	predicted gene 9864	28257	0.26
chr6_144895356_144895507	1.39	Gm22792	predicted gene, 22792	91799	0.07
chr1_100298746_100298897	1.31	Gm29667	predicted gene 29667	16030	0.18
chr19_26823641_26823967	1.17	4931403E22Rik	RIKEN cDNA 4931403E22 gene	103	0.97
chr8_25609907_25610083	1.16	Gm23184	predicted gene, 23184	563	0.58
chr11_16798476_16798627	1.16	Egfros	epidermal growth factor receptor, opposite strand	32151	0.16
chr3_148832133_148832284	1.03	Adgrl2	adhesion G protein-coupled receptor L2	1720	0.51
chr2_73628966_73629117	1.02	Chn1	chimerin 1	3301	0.21
chr13_63665698_63665976	1.01	Gm47387	predicted gene, 47387	4040	0.18
chr7_140722780_140722931	1.01	Olfr542-ps1	olfactory receptor 542, pseudogene 1	1573	0.22
chr16_87627804_87628113	0.93	Gm22808	predicted gene, 22808	6838	0.21
chr14_86300654_86300845	0.92	Gm32815	predicted gene, 32815	1015	0.44
chr12_104083020_104083260	0.90	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	2491	0.16
chr4_44777019_44777170	0.90	Zcchc7	zinc finger, CCHC domain containing 7	16650	0.16
chr12_51274477_51274668	0.88	Rps11-ps4	ribosomal protein S11, pseudogene 4	22915	0.22
chr10_24362567_24362800	0.86	Gm15271	predicted gene 15271	84807	0.08
chr19_44401904_44402310	0.83	Scd1	stearoyl-Coenzyme A desaturase 1	4583	0.17
chr9_116136676_116136901	0.81	Tgfbr2	transforming growth factor, beta receptor II	38477	0.15
chr2_24040580_24040761	0.80	Hnmt	histamine N-methyltransferase	8196	0.23
chr4_123990670_123991070	0.79	Gm12902	predicted gene 12902	64636	0.08
chr13_118829008_118829159	0.79	Gm47335	predicted gene, 47335	29331	0.22
chr4_65080374_65080537	0.79	Pappa	pregnancy-associated plasma protein A	43719	0.19
chr11_16885540_16885691	0.78	Egfr	epidermal growth factor receptor	7465	0.21
chr3_111344475_111344661	0.77	Gm9314	predicted gene 9314	21711	0.29
chr9_122826708_122826859	0.77	Gm35549	predicted gene, 35549	17103	0.1
chr7_107574446_107574681	0.77	Olfml1	olfactomedin-like 1	6797	0.16
chr10_69217231_69217448	0.76	Rhobtb1	Rho-related BTB domain containing 1	2037	0.3
chr3_60525375_60525543	0.76	Mbnl1	muscleblind like splicing factor 1	2669	0.31
chr19_40153747_40153898	0.73	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	33464	0.13
chr11_16758574_16758725	0.71	Egfr	epidermal growth factor receptor	6419	0.21
chr17_71222209_71222384	0.70	Lpin2	lipin 2	9137	0.17
chr9_74328635_74328791	0.68	Gm24141	predicted gene, 24141	33897	0.17
chr13_28877494_28877645	0.68	2610307P16Rik	RIKEN cDNA 2610307P16 gene	5887	0.2
chr2_42022610_42022815	0.68	Gm13461	predicted gene 13461	33883	0.23
chr3_18250842_18251072	0.66	Cyp7b1	cytochrome P450, family 7, subfamily b, polypeptide 1	7619	0.24
chr9_74872523_74872674	0.66	Onecut1	one cut domain, family member 1	6114	0.16
chr12_57537784_57538085	0.66	Foxa1	forkhead box A1	8187	0.15
chr9_74885383_74885534	0.66	Onecut1	one cut domain, family member 1	18974	0.14
chr8_94394237_94394701	0.65	Herpud1	homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1	938	0.39
chr1_84993315_84993466	0.63	Gm29284	predicted gene 29284	358	0.79
chr5_52945521_52945741	0.62	Gm23532	predicted gene, 23532	13831	0.15
chr3_97649987_97650151	0.61	Prkab2	protein kinase, AMP-activated, beta 2 non-catalytic subunit	8124	0.13
chr8_73953761_73954148	0.61	Gm7948	predicted gene 7948	82261	0.11
chr2_134500653_134500804	0.59	Hao1	hydroxyacid oxidase 1, liver	53579	0.17
chr18_54739961_54740121	0.58	Gm5821	predicted gene 5821	26091	0.21
chr2_36201411_36201590	0.58	Gm13429	predicted gene 13429	814	0.51
chr3_61217484_61217722	0.57	Gm37719	predicted gene, 37719	73843	0.1
chr2_35184678_35184843	0.57	Rab14	RAB14, member RAS oncogene family	612	0.69
chr11_16839622_16839885	0.57	Egfros	epidermal growth factor receptor, opposite strand	9051	0.21
chr13_24360335_24360523	0.57	Gm11342	predicted gene 11342	15521	0.12
chr4_123990393_123990580	0.56	Gm12902	predicted gene 12902	64252	0.08
chr14_69628830_69628981	0.56	Gm27177	predicted gene 27177	11369	0.11
chr1_151718954_151719119	0.54	2810414N06Rik	RIKEN cDNA 2810414N06 gene	35982	0.14
chr16_42947764_42948084	0.54	Ndufs5-ps	NADH:ubiquinone oxidoreductase core subunit S5, pseudogene	7707	0.21
chr13_91208892_91209073	0.53	Gm17450	predicted gene, 17450	11470	0.19
chr4_109104769_109104920	0.53	Osbpl9	oxysterol binding protein-like 9	3187	0.27
chr10_87932167_87932318	0.52	Tyms-ps	thymidylate synthase, pseudogene	34605	0.14
chr16_11406443_11406626	0.51	Snx29	sorting nexin 29	123	0.97
chr17_64607771_64607970	0.51	Man2a1	mannosidase 2, alpha 1	7134	0.26
chr11_84198789_84199054	0.50	Acaca	acetyl-Coenzyme A carboxylase alpha	3483	0.22
chr3_118443694_118443845	0.50	Gm9916	predicted gene 9916	8999	0.15
chr7_110192854_110193204	0.50	Swap70	SWA-70 protein	28682	0.13
chr17_80022007_80022158	0.50	Gm22215	predicted gene, 22215	11432	0.14
chr16_65665507_65665824	0.50	Gm49633	predicted gene, 49633	52246	0.14
chr10_8642632_8642823	0.50	Gm24374	predicted gene, 24374	207	0.96
chr4_45800810_45800979	0.50	Aldh1b1	aldehyde dehydrogenase 1 family, member B1	1773	0.28
chr14_18369164_18369315	0.49	Ube2e1	ubiquitin-conjugating enzyme E2E 1	37380	0.15
chr18_39816253_39816404	0.49	Pabpc2	poly(A) binding protein, cytoplasmic 2	42831	0.17
chr4_121078016_121078199	0.49	Zmpste24	zinc metallopeptidase, STE24	369	0.74
chr11_35015732_35015915	0.49	Slit3	slit guidance ligand 3	105401	0.07
chr16_43169836_43170008	0.48	Gm15712	predicted gene 15712	14651	0.21
chr2_28618402_28618756	0.48	Gfi1b	growth factor independent 1B	3174	0.15
chr13_80892366_80892552	0.47	Arrdc3	arrestin domain containing 3	1941	0.29
chr3_149234408_149234559	0.47	Gm10287	predicted gene 10287	8738	0.21
chr3_133759501_133760150	0.46	Gm6135	prediticted gene 6135	31679	0.18
chr12_110576051_110576208	0.46	B930059L03Rik	RIKEN cDNA B930059L03 gene	14383	0.14
chr3_18167606_18167757	0.45	Gm23686	predicted gene, 23686	9944	0.24
chr11_97383112_97383279	0.45	Socs7	suppressor of cytokine signaling 7	5758	0.15
chr1_56979180_56979331	0.44	Satb2	special AT-rich sequence binding protein 2	605	0.68
chr13_44437957_44438156	0.44	1700029N11Rik	RIKEN cDNA 1700029N11 gene	1656	0.27
chr12_95589166_95589349	0.43	Gm22246	predicted gene, 22246	30561	0.21
chr9_98418368_98418712	0.43	Rbp1	retinol binding protein 1, cellular	4421	0.24
chr3_95872352_95872534	0.42	C920021L13Rik	RIKEN cDNA C920021L13 gene	912	0.26
chrX_85734642_85734808	0.42	Gk	glycerol kinase	2885	0.21
chr7_67578755_67579151	0.42	Lrrc28	leucine rich repeat containing 28	797	0.57
chr11_16882054_16882234	0.42	Egfr	epidermal growth factor receptor	3994	0.24
chr18_39438249_39438499	0.42	Nr3c1	nuclear receptor subfamily 3, group C, member 1	48858	0.13
chr6_108253104_108253265	0.41	Itpr1	inositol 1,4,5-trisphosphate receptor 1	226	0.96
chr12_69759378_69759543	0.41	Mir681	microRNA 681	4484	0.15
chr6_16797841_16798030	0.41	Gm36669	predicted gene, 36669	20411	0.22
chr10_86350127_86350278	0.41	Timp3	tissue inhibitor of metalloproteinase 3	47348	0.13
chr2_13522226_13522421	0.41	Trdmt1	tRNA aspartic acid methyltransferase 1	22327	0.19
chr12_80336463_80336614	0.41	Dcaf5	DDB1 and CUL4 associated factor 5	40154	0.1
chr13_16574847_16575001	0.41	Gm48497	predicted gene, 48497	41103	0.17
chr2_122251200_122251358	0.41	Sord	sorbitol dehydrogenase	16530	0.1
chr3_146504144_146504452	0.41	Rpf1	ribosome production factor 1 homolog	3926	0.15
chr11_111269853_111270023	0.41	Gm11675	predicted gene 11675	6162	0.34
chr10_107041161_107041312	0.40	Gm18040	predicted gene, 18040	18113	0.19
chr2_58773911_58774203	0.40	Upp2	uridine phosphorylase 2	8732	0.21
chr10_87872347_87872727	0.40	Igf1os	insulin-like growth factor 1, opposite strand	9156	0.2
chr15_62529162_62529323	0.40	Gm41333	predicted gene, 41333	38733	0.21
chr7_47035073_47035236	0.39	Gm45474	predicted gene 45474	15142	0.08
chr6_140301064_140301256	0.39	Gm3961	predicted gene 3961	4704	0.2
chr11_51727078_51727230	0.39	Gm25291	predicted gene, 25291	10768	0.14
chr11_32651005_32651314	0.39	Fbxw11	F-box and WD-40 domain protein 11	8255	0.23
chr15_55186898_55187049	0.38	Deptor	DEP domain containing MTOR-interacting protein	53520	0.11
chr1_164858611_164858762	0.38	Gm20743	predicted gene, 20743	4447	0.19
chr13_34990551_34990817	0.38	Eci2	enoyl-Coenzyme A delta isomerase 2	1119	0.36
chr9_20730600_20730850	0.38	Olfm2	olfactomedin 2	2496	0.23
chr18_55793738_55793905	0.38	Gm8614	predicted gene 8614	45128	0.14
chr19_45902358_45902683	0.37	Gm6813	predicted gene 6813	24394	0.14
chr19_44394517_44394772	0.37	Scd1	stearoyl-Coenzyme A desaturase 1	12046	0.14
chr10_86689548_86689699	0.37	Gm15344	predicted gene 15344	3472	0.09
chr16_31432572_31432723	0.37	Gm15743	predicted gene 15743	2871	0.17
chr2_132595408_132595654	0.37	AU019990	expressed sequence AU019990	2664	0.22
chr1_88055296_88055515	0.37	Ugt1a10	UDP glycosyltransferase 1 family, polypeptide A10	6	0.94
chr16_46623333_46623484	0.37	Gm17900	predicted gene, 17900	85573	0.1
chr5_87019691_87019873	0.37	Gm18635	predicted gene, 18635	5622	0.12
chr3_89147086_89147561	0.37	Hcn3	hyperpolarization-activated, cyclic nucleotide-gated K+ 3	3891	0.08
chr15_53297534_53297744	0.37	Ext1	exostosin glycosyltransferase 1	48020	0.18
chr13_80895235_80895839	0.37	Arrdc3	arrestin domain containing 3	5019	0.18
chr19_44027305_44027461	0.36	Cyp2c23	cytochrome P450, family 2, subfamily c, polypeptide 23	1816	0.28
chr5_135367975_135368144	0.36	Nsun5	NOL1/NOP2/Sun domain family, member 5	1894	0.22
chr5_33465562_33465766	0.36	Gm43851	predicted gene 43851	28200	0.15
chr2_160848002_160848255	0.36	Gm11447	predicted gene 11447	2515	0.22
chr2_4546547_4546716	0.36	Frmd4a	FERM domain containing 4A	13123	0.2
chr9_103363870_103364326	0.36	Cdv3	carnitine deficiency-associated gene expressed in ventricle 3	799	0.56
chr11_119048222_119048411	0.36	Cbx8	chromobox 8	7347	0.16
chr9_122357372_122357607	0.35	Abhd5	abhydrolase domain containing 5	5700	0.15
chr6_71999990_72000187	0.35	Gm26628	predicted gene, 26628	36313	0.1
chr2_14596063_14596214	0.35	Cacnb2	calcium channel, voltage-dependent, beta 2 subunit	6950	0.13
chr16_93369696_93369958	0.35	Mir802	microRNA 802	107	0.95
chr11_28702228_28702389	0.35	2810471M01Rik	RIKEN cDNA 2810471M01 gene	20744	0.15
chr3_93589735_93589907	0.35	S100a10	S100 calcium binding protein A10 (calpactin)	29094	0.09
chr9_104246994_104247311	0.35	Dnajc13	DnaJ heat shock protein family (Hsp40) member C13	325	0.87
chr10_115337191_115337351	0.34	Tmem19	transmembrane protein 19	11793	0.14
chr7_66740464_66740653	0.34	Gm10623	predicted gene 10623	2754	0.19
chr19_55110942_55111169	0.34	Gpam	glycerol-3-phosphate acyltransferase, mitochondrial	7964	0.2
chr9_14061834_14061992	0.34	1700019J19Rik	RIKEN cDNA 1700019J19 gene	27707	0.17
chr7_118715006_118715199	0.33	Ccp110	centriolar coiled coil protein 110	272	0.86
chr14_60413760_60413920	0.33	Gm6066	predicted gene 6066	28139	0.17
chr7_135720125_135720308	0.33	Mki67	antigen identified by monoclonal antibody Ki 67	3855	0.2
chr3_144446211_144446394	0.33	Gm5857	predicted gene 5857	18630	0.18
chr9_67824580_67824733	0.33	C2cd4a	C2 calcium-dependent domain containing 4A	7674	0.18
chr18_39446995_39447226	0.33	Nr3c1	nuclear receptor subfamily 3, group C, member 1	40122	0.16
chr19_3557401_3557552	0.33	Ppp6r3	protein phosphatase 6, regulatory subunit 3	18220	0.14
chr6_118990185_118990336	0.33	Cacna1c	calcium channel, voltage-dependent, L type, alpha 1C subunit	89747	0.09
chr3_18164974_18165125	0.33	Gm23686	predicted gene, 23686	12576	0.23
chr4_116689870_116690150	0.33	Prdx1	peroxiredoxin 1	2698	0.15
chr8_24445565_24445716	0.33	Gm44620	predicted gene 44620	1457	0.34
chr5_90465453_90465660	0.32	Alb	albumin	2856	0.22
chr10_69253303_69253474	0.32	Rhobtb1	Rho-related BTB domain containing 1	12249	0.19
chr3_136674419_136674771	0.32	Ppp3ca	protein phosphatase 3, catalytic subunit, alpha isoform	3825	0.27
chr10_89573725_89573906	0.32	Gm48087	predicted gene, 48087	18096	0.17
chr11_16817054_16817205	0.32	Egfros	epidermal growth factor receptor, opposite strand	13573	0.21
chr14_30530847_30531018	0.32	Dcp1a	decapping mRNA 1A	7225	0.15
chrX_60392083_60392234	0.32	Mir505	microRNA 505	2334	0.31
chr3_109307549_109307748	0.32	Vav3	vav 3 oncogene	33005	0.21
chr15_53238274_53238425	0.32	Ext1	exostosin glycosyltransferase 1	42094	0.21
chr12_117728620_117728794	0.32	Gm18955	predicted gene, 18955	4735	0.24
chrX_95163511_95163805	0.32	Arhgef9	CDC42 guanine nucleotide exchange factor (GEF) 9	2167	0.36
chr7_87371791_87371944	0.32	Tyr	tyrosinase	121525	0.05
chr13_112316831_112317157	0.32	Ankrd55	ankyrin repeat domain 55	1460	0.39
chr9_74791015_74791321	0.31	Gm22315	predicted gene, 22315	9098	0.19
chr3_61217316_61217479	0.31	Gm37719	predicted gene, 37719	74049	0.1
chr1_23913075_23913318	0.31	Smap1	small ArfGAP 1	3460	0.31
chr4_135819951_135820102	0.31	Myom3	myomesin family, member 3	19382	0.11
chr2_73491256_73491419	0.31	Wipf1	WAS/WASL interacting protein family, member 1	4868	0.19
chr17_43858229_43858402	0.31	Rcan2	regulator of calcineurin 2	54312	0.15
chr9_74319240_74319391	0.31	Gm24141	predicted gene, 24141	43295	0.15
chr16_43408501_43408652	0.31	Gm15713	predicted gene 15713	11620	0.2
chr18_65154932_65155123	0.31	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	707	0.74
chr11_51753632_51753825	0.31	Sec24a	Sec24 related gene family, member A (S. cerevisiae)	2483	0.22
chr1_67182326_67182537	0.31	Cps1	carbamoyl-phosphate synthetase 1	59405	0.11
chr17_53869978_53870142	0.31	Mrps36-ps1	mitichondrial ribosomal protein S36, pseudogene 1	3040	0.16
chr16_43037670_43037825	0.31	Ndufs5-ps	NADH:ubiquinone oxidoreductase core subunit S5, pseudogene	82116	0.09
chr19_14516462_14516647	0.31	Tle4	transducin-like enhancer of split 4	78985	0.11
chr4_40698726_40698877	0.30	Aptx	aprataxin	3915	0.15
chr2_82446048_82446229	0.30	A130030D18Rik	RIKEN cDNA A130030D18 gene	53936	0.14
chr10_53398045_53398224	0.30	Gm36229	predicted gene, 36229	11748	0.13
chr13_8847939_8848370	0.30	Wdr37	WD repeat domain 37	517	0.67
chr1_163817675_163817827	0.30	Kifap3	kinesin-associated protein 3	38168	0.16
chr15_3495710_3495861	0.30	Ghr	growth hormone receptor	24141	0.25
chr18_12682851_12683167	0.30	Ttc39c	tetratricopeptide repeat domain 39C	6719	0.16
chr2_18048778_18049088	0.30	Skida1	SKI/DACH domain containing 1	98	0.94
chr18_39827979_39828276	0.30	Pabpc2	poly(A) binding protein, cytoplasmic 2	54630	0.14
chr6_65569857_65570008	0.30	Tnip3	TNFAIP3 interacting protein 3	20466	0.22
chr2_5939653_5939804	0.30	Dhtkd1	dehydrogenase E1 and transketolase domain containing 1	3015	0.22
chr2_113795317_113795493	0.30	Scg5	secretogranin V	33357	0.14
chr10_99172107_99172427	0.30	Poc1b	POC1 centriolar protein B	983	0.45
chr1_107939441_107939624	0.30	D830032E09Rik	RIKEN cDNA D830032E09 gene	2823	0.25
chr5_87455158_87455319	0.30	Ugt2a2	UDP glucuronosyltransferase 2 family, polypeptide A2	27020	0.09
chr13_5804589_5804740	0.30	Gm26043	predicted gene, 26043	17194	0.19
chr17_54414428_54414603	0.30	Trp53-ps	transformation related protein 53, pseudogene	5165	0.22
chr16_21779191_21779393	0.30	Gm24898	predicted gene, 24898	5179	0.14
chr6_134743647_134743846	0.29	Dusp16	dual specificity phosphatase 16	80	0.96
chr10_38136267_38136418	0.29	Gm31378	predicted gene, 31378	14281	0.19
chr1_134567570_134567757	0.29	Kdm5b	lysine (K)-specific demethylase 5B	7456	0.14

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nkx6-3_Dbx2_Barx2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.1	0.4	GO:0030327	prenylated protein catabolic process(GO:0030327)
0.1	0.4	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.1	0.6	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.1	0.3	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.3	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.1	0.3	GO:0006068	ethanol catabolic process(GO:0006068)
0.1	0.3	GO:0015014	heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1	0.3	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.1	0.2	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.1	0.3	GO:1903964	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1	0.2	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.1	0.3	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.1	0.2	GO:0060300	regulation of cytokine activity(GO:0060300)
0.1	0.2	GO:0035696	monocyte extravasation(GO:0035696) regulation of monocyte extravasation(GO:2000437)
0.1	0.3	GO:1903071	positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1	0.2	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.1	0.2	GO:0060221	retinal rod cell differentiation(GO:0060221)
0.1	0.3	GO:1900086	positive regulation of peptidyl-tyrosine autophosphorylation(GO:1900086)
0.1	0.3	GO:0006207	'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856)
0.1	0.2	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:0019371	cyclooxygenase pathway(GO:0019371)
0.0	0.2	GO:0060155	platelet dense granule organization(GO:0060155)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.2	GO:0001907	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.3	GO:0021902	commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.0	0.2	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.1	GO:0060847	endothelial cell fate specification(GO:0060847)
0.0	0.4	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.5	GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.0	0.2	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.3	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.1	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.2	GO:0070562	regulation of vitamin D receptor signaling pathway(GO:0070562)
0.0	0.1	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.0	GO:0006067	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:0070384	Harderian gland development(GO:0070384)
0.0	0.2	GO:0010612	regulation of cardiac muscle adaptation(GO:0010612) regulation of cardiac muscle hypertrophy in response to stress(GO:1903242)
0.0	0.4	GO:0006517	protein deglycosylation(GO:0006517)
0.0	0.4	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0097167	circadian regulation of translation(GO:0097167)
0.0	0.1	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.0	0.1	GO:1990705	cholangiocyte proliferation(GO:1990705)
0.0	0.4	GO:0000188	inactivation of MAPK activity(GO:0000188)
0.0	0.3	GO:0045176	apical protein localization(GO:0045176)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0	0.1	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.0	0.1	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.1	GO:0018197	peptidyl-aspartic acid modification(GO:0018197)
0.0	0.1	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.0	GO:1902996	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.1	GO:0050883	musculoskeletal movement, spinal reflex action(GO:0050883)
0.0	0.2	GO:0006971	hypotonic response(GO:0006971)
0.0	0.1	GO:0014016	neuroblast differentiation(GO:0014016)
0.0	0.2	GO:0008090	retrograde axonal transport(GO:0008090)
0.0	0.1	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.0	0.1	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.2	GO:0042977	activation of JAK2 kinase activity(GO:0042977)
0.0	0.1	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.1	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.1	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
0.0	0.1	GO:0035811	negative regulation of urine volume(GO:0035811)
0.0	0.0	GO:2000304	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0	0.0	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.2	GO:0021670	lateral ventricle development(GO:0021670)
0.0	0.0	GO:0061343	cell adhesion involved in heart morphogenesis(GO:0061343)
0.0	0.2	GO:0045713	low-density lipoprotein particle receptor biosynthetic process(GO:0045713)
0.0	0.3	GO:0030854	positive regulation of granulocyte differentiation(GO:0030854)
0.0	0.1	GO:0021960	anterior commissure morphogenesis(GO:0021960)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.1	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.0	GO:0046005	positive regulation of circadian sleep/wake cycle, REM sleep(GO:0046005)
0.0	0.1	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
0.0	0.2	GO:0031848	protection from non-homologous end joining at telomere(GO:0031848)
0.0	0.2	GO:0016127	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0	0.2	GO:0055091	phospholipid homeostasis(GO:0055091)
0.0	0.1	GO:0006407	rRNA export from nucleus(GO:0006407)
0.0	0.1	GO:0015889	cobalamin transport(GO:0015889)
0.0	0.1	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.3	GO:0030449	regulation of complement activation(GO:0030449)
0.0	0.1	GO:0042769	DNA damage response, detection of DNA damage(GO:0042769)
0.0	0.1	GO:0006776	vitamin A metabolic process(GO:0006776)
0.0	0.0	GO:1904504	regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
0.0	0.0	GO:0032488	Cdc42 protein signal transduction(GO:0032488)
0.0	0.1	GO:0032383	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0	0.1	GO:1905049	negative regulation of metalloendopeptidase activity(GO:1904684) negative regulation of metallopeptidase activity(GO:1905049)
0.0	0.1	GO:0035284	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.1	GO:0031585	regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031585)
0.0	0.1	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.1	GO:0009957	epidermal cell fate specification(GO:0009957)
0.0	0.0	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.5	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	0.1	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0019532	oxalate transport(GO:0019532)
0.0	0.1	GO:0010739	positive regulation of protein kinase A signaling(GO:0010739)
0.0	0.1	GO:0032020	ISG15-protein conjugation(GO:0032020)
0.0	0.0	GO:0072566	chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
0.0	0.1	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.0	GO:0006041	glucosamine metabolic process(GO:0006041)
0.0	0.1	GO:0032058	positive regulation of translational initiation in response to stress(GO:0032058)
0.0	0.0	GO:0018879	biphenyl metabolic process(GO:0018879)
0.0	0.1	GO:0000957	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.1	GO:0045908	negative regulation of vasodilation(GO:0045908)
0.0	0.2	GO:0006983	ER overload response(GO:0006983)
0.0	0.0	GO:0034093	positive regulation of maintenance of sister chromatid cohesion(GO:0034093) positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.0	0.0	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.0	0.0	GO:1901843	positive regulation of high voltage-gated calcium channel activity(GO:1901843)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.0	GO:0070100	negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0	0.0	GO:0034421	post-translational protein acetylation(GO:0034421)
0.0	0.2	GO:0006968	cellular defense response(GO:0006968)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0010801	negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.0	0.0	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.0	0.1	GO:2000503	positive regulation of natural killer cell chemotaxis(GO:2000503)
0.0	0.0	GO:0071233	response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0	0.0	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.0	GO:0021912	regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification(GO:0021912)
0.0	0.1	GO:0048254	snoRNA localization(GO:0048254)
0.0	0.0	GO:0072531	pyrimidine-containing compound transmembrane transport(GO:0072531)
0.0	0.0	GO:1900227	positive regulation of NLRP3 inflammasome complex assembly(GO:1900227)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.2	GO:0009312	oligosaccharide biosynthetic process(GO:0009312)
0.0	0.0	GO:1903587	regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903587)
0.0	0.0	GO:0019086	late viral transcription(GO:0019086)
0.0	0.1	GO:2001260	regulation of semaphorin-plexin signaling pathway(GO:2001260)
0.0	0.0	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0	0.0	GO:0042427	serotonin biosynthetic process(GO:0042427) primary amino compound biosynthetic process(GO:1901162)
0.0	0.0	GO:0015959	diadenosine polyphosphate metabolic process(GO:0015959)
0.0	0.0	GO:0019065	receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509)
0.0	0.0	GO:0003162	atrioventricular node development(GO:0003162)
0.0	0.0	GO:0043096	purine nucleobase salvage(GO:0043096)
0.0	0.0	GO:0070782	phosphatidylserine exposure on apoptotic cell surface(GO:0070782)
0.0	0.0	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.1	GO:0061418	regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.0	0.1	GO:0031468	nuclear envelope reassembly(GO:0031468)
0.0	0.1	GO:0072513	positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.0	0.3	GO:0006376	mRNA splice site selection(GO:0006376)
0.0	0.0	GO:0070874	negative regulation of glycogen metabolic process(GO:0070874)
0.0	0.0	GO:0046100	hypoxanthine metabolic process(GO:0046100) hypoxanthine biosynthetic process(GO:0046101)
0.0	0.1	GO:0007343	egg activation(GO:0007343)
0.0	0.0	GO:0043622	cortical microtubule organization(GO:0043622)
0.0	0.0	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.0	0.0	GO:0071042	U1 snRNA 3'-end processing(GO:0034473) U5 snRNA 3'-end processing(GO:0034476) nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.0	0.0	GO:0038171	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.1	GO:0008298	intracellular mRNA localization(GO:0008298)
0.0	0.0	GO:0010046	response to mycotoxin(GO:0010046)
0.0	0.0	GO:0035973	aggrephagy(GO:0035973)
0.0	0.1	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.0	GO:0070537	histone H2A K63-linked deubiquitination(GO:0070537)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.0	GO:2000286	receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
0.0	0.0	GO:0021698	cerebellar cortex structural organization(GO:0021698)
0.0	0.4	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.0	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.0	0.1	GO:0071380	cellular response to prostaglandin E stimulus(GO:0071380)
0.0	0.1	GO:0045792	negative regulation of cell size(GO:0045792)
0.0	0.3	GO:0000470	maturation of LSU-rRNA(GO:0000470)
0.0	0.0	GO:0003219	cardiac right ventricle formation(GO:0003219)
0.0	0.0	GO:0002282	microglial cell activation involved in immune response(GO:0002282)
0.0	0.0	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.0	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.0	0.1	GO:0015871	choline transport(GO:0015871)
0.0	0.0	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.0	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0097105	presynaptic membrane assembly(GO:0097105)
0.0	0.0	GO:0006382	adenosine to inosine editing(GO:0006382)
0.0	0.0	GO:0072221	distal convoluted tubule development(GO:0072025) DCT cell differentiation(GO:0072069) metanephric distal convoluted tubule development(GO:0072221) metanephric distal tubule development(GO:0072235) metanephric DCT cell differentiation(GO:0072240)
0.0	0.1	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.0	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.1	GO:0070166	enamel mineralization(GO:0070166)
0.0	0.0	GO:0051031	tRNA transport(GO:0051031)
0.0	0.0	GO:0042695	thelarche(GO:0042695) mammary gland branching involved in thelarche(GO:0060744)
0.0	0.1	GO:0045721	negative regulation of gluconeogenesis(GO:0045721)
0.0	0.0	GO:0045590	negative regulation of regulatory T cell differentiation(GO:0045590)
0.0	0.0	GO:0003221	right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.0	0.0	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.0	GO:0009106	lipoate metabolic process(GO:0009106)
0.0	0.0	GO:0072307	metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0	0.1	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.0	0.0	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.1	GO:0048630	skeletal muscle tissue growth(GO:0048630)
0.0	0.1	GO:0051315	attachment of mitotic spindle microtubules to kinetochore(GO:0051315)
0.0	0.0	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.1	GO:0097341	inhibition of cysteine-type endopeptidase activity(GO:0097340) zymogen inhibition(GO:0097341) inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
0.0	0.1	GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0	0.2	GO:0070498	interleukin-1-mediated signaling pathway(GO:0070498)
0.0	0.0	GO:0042737	drug catabolic process(GO:0042737)
0.0	0.0	GO:2000623	regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.5	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.2	0.5	GO:0031088	platelet dense granule membrane(GO:0031088)
0.1	0.3	GO:0097413	Lewy body(GO:0097413)
0.1	0.5	GO:0045098	type III intermediate filament(GO:0045098)
0.1	0.3	GO:0071203	WASH complex(GO:0071203)
0.1	0.2	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.1	0.3	GO:0042406	extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1	0.2	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.2	GO:0035867	alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
0.0	0.1	GO:0005955	calcineurin complex(GO:0005955)
0.0	0.2	GO:0005915	zonula adherens(GO:0005915)
0.0	0.3	GO:0097208	alveolar lamellar body(GO:0097208)
0.0	0.1	GO:0033269	internode region of axon(GO:0033269)
0.0	0.1	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.1	GO:0005726	perichromatin fibrils(GO:0005726)
0.0	0.1	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.1	GO:0032010	phagolysosome(GO:0032010)
0.0	0.3	GO:0000124	SAGA complex(GO:0000124)
0.0	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.1	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.2	GO:1990075	periciliary membrane compartment(GO:1990075)
0.0	0.1	GO:1990131	EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0	0.3	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.3	GO:0030134	ER to Golgi transport vesicle(GO:0030134)
0.0	0.1	GO:0042382	paraspeckles(GO:0042382)
0.0	0.1	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.1	GO:0000811	GINS complex(GO:0000811)
0.0	0.2	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.1	GO:0042788	polysomal ribosome(GO:0042788)
0.0	0.2	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0	0.2	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0045293	mRNA editing complex(GO:0045293)
0.0	0.0	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.2	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.0	GO:0000125	PCAF complex(GO:0000125)
0.0	0.4	GO:0005801	cis-Golgi network(GO:0005801)
0.0	0.1	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.1	GO:0035102	PRC1 complex(GO:0035102)
0.0	0.1	GO:0061617	MICOS complex(GO:0061617)
0.0	0.1	GO:0070761	pre-snoRNP complex(GO:0070761)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.1	GO:0005916	fascia adherens(GO:0005916)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0034663	endoplasmic reticulum chaperone complex(GO:0034663)
0.0	0.1	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0012510	trans-Golgi network transport vesicle membrane(GO:0012510)
0.0	0.0	GO:0033596	TSC1-TSC2 complex(GO:0033596)
0.0	0.0	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
0.0	0.0	GO:0043202	lysosomal lumen(GO:0043202)
0.0	0.1	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.0	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.0	GO:0097418	neurofibrillary tangle(GO:0097418)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.5	1.6	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.1	0.4	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.1	0.5	GO:0034056	estrogen response element binding(GO:0034056)
0.1	0.3	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.3	GO:0050508	glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.1	0.2	GO:0001069	regulatory region RNA binding(GO:0001069)
0.1	0.2	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.1	0.3	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	0.1	GO:0043125	ErbB-3 class receptor binding(GO:0043125)
0.1	0.2	GO:1990239	steroid hormone binding(GO:1990239)
0.1	0.2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.1	0.2	GO:0038181	bile acid receptor activity(GO:0038181)
0.0	0.3	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.3	GO:0008508	bile acid:sodium symporter activity(GO:0008508)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.4	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0016716	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
0.0	0.1	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.1	GO:0004022	alcohol dehydrogenase (NAD) activity(GO:0004022)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.2	GO:0008294	calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0008449	N-acetylglucosamine-6-sulfatase activity(GO:0008449)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.1	GO:0009374	biotin binding(GO:0009374)
0.0	0.0	GO:0004769	steroid delta-isomerase activity(GO:0004769)
0.0	0.1	GO:0005119	smoothened binding(GO:0005119)
0.0	0.1	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.1	GO:0005007	fibroblast growth factor-activated receptor activity(GO:0005007)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0038064	collagen receptor activity(GO:0038064)
0.0	0.1	GO:0086007	voltage-gated calcium channel activity involved in cardiac muscle cell action potential(GO:0086007)
0.0	0.2	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.2	GO:0001846	opsonin binding(GO:0001846)
0.0	0.2	GO:0036122	BMP binding(GO:0036122)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.2	GO:0016004	phospholipase activator activity(GO:0016004)
0.0	0.7	GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.1	GO:0001665	alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.1	GO:0033192	calmodulin-dependent protein phosphatase activity(GO:0033192)
0.0	0.2	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.1	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.0	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.1	GO:0035184	histone threonine kinase activity(GO:0035184)
0.0	0.1	GO:0070538	oleic acid binding(GO:0070538)
0.0	0.1	GO:0097109	neuroligin family protein binding(GO:0097109)
0.0	0.1	GO:0001075	transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0	0.2	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.1	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.1	GO:0015220	choline transmembrane transporter activity(GO:0015220)
0.0	0.2	GO:0008568	microtubule-severing ATPase activity(GO:0008568)
0.0	0.1	GO:2001070	starch binding(GO:2001070)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0003680	AT DNA binding(GO:0003680)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	0.0	GO:0004427	inorganic diphosphatase activity(GO:0004427)
0.0	0.1	GO:0005173	stem cell factor receptor binding(GO:0005173)
0.0	0.0	GO:0042030	ATPase inhibitor activity(GO:0042030)
0.0	0.1	GO:0004594	pantothenate kinase activity(GO:0004594)
0.0	0.3	GO:0031489	myosin V binding(GO:0031489)
0.0	0.0	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.0	GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514)
0.0	0.1	GO:1990405	protein antigen binding(GO:1990405)
0.0	0.1	GO:0001602	pancreatic polypeptide receptor activity(GO:0001602)
0.0	0.1	GO:0016668	oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.0	0.0	GO:0031826	type 2A serotonin receptor binding(GO:0031826)
0.0	0.0	GO:0047391	alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.0	GO:0019770	IgG receptor activity(GO:0019770)
0.0	0.1	GO:0003831	beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
0.0	0.0	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.1	GO:0019841	retinol binding(GO:0019841)
0.0	0.2	GO:0070402	NADPH binding(GO:0070402)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0031690	adrenergic receptor binding(GO:0031690)
0.0	0.1	GO:0019531	oxalate transmembrane transporter activity(GO:0019531)
0.0	0.0	GO:0008526	phosphatidylinositol transporter activity(GO:0008526)
0.0	0.0	GO:0004723	calcium-dependent protein serine/threonine phosphatase activity(GO:0004723)
0.0	0.0	GO:0000293	ferric-chelate reductase activity(GO:0000293)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.2	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	0.0	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.6	GO:0005080	protein kinase C binding(GO:0005080)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.1	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.0	GO:0016880	acid-ammonia (or amide) ligase activity(GO:0016880)
0.0	0.0	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.1	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.0	GO:0008240	tripeptidyl-peptidase activity(GO:0008240)
0.0	0.1	GO:1990446	U1 snRNP binding(GO:1990446)
0.0	0.0	GO:0008310	single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.0	0.3	GO:0001205	transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0	0.0	GO:0017034	Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.0	0.0	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.0	0.1	GO:0002151	G-quadruplex RNA binding(GO:0002151)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.9	PID ER NONGENOMIC PATHWAY	Plasma membrane estrogen receptor signaling
0.0	0.1	PID ERBB2 ERBB3 PATHWAY	ErbB2/ErbB3 signaling events
0.0	0.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	0.2	PID ECADHERIN KERATINOCYTE PATHWAY	E-cadherin signaling in keratinocytes
0.0	0.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	0.1	ST G ALPHA I PATHWAY	G alpha i Pathway
0.0	0.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.0	0.5	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins
0.0	0.3	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.2	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.0	0.1	PID PTP1B PATHWAY	Signaling events mediated by PTP1B
0.0	0.1	SA G2 AND M PHASES	Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.0	0.2	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.5	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.6	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.3	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	0.4	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.0	0.1	REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA	Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.2	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.0	0.2	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0	0.5	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.0	0.3	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.2	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.6	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
0.0	0.0	REACTOME DAG AND IP3 SIGNALING	Genes involved in DAG and IP3 signaling
0.0	0.2	REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY	Genes involved in Adenylate cyclase activating pathway
0.0	0.5	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.4	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	0.2	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.1	REACTOME BIOLOGICAL OXIDATIONS	Genes involved in Biological oxidations
0.0	0.1	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.3	REACTOME ADHERENS JUNCTIONS INTERACTIONS	Genes involved in Adherens junctions interactions
0.0	0.1	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
0.0	0.3	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	0.1	REACTOME CALNEXIN CALRETICULIN CYCLE	Genes involved in Calnexin/calreticulin cycle
0.0	0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling