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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Nr4a3

Z-value: 2.30

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Transcription factors associated with Nr4a3

Gene Symbol	Gene ID	Gene Info
Nr4a3 Ensembl NCBI MGI UniProt	ENSMUSG00000028341.3	Nr4a3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Nr4a3	chr4_48042684_48042844	2389	0.338726	0.94	6.0e-03	Click!
Nr4a3	chr4_48046634_48046887	1529	0.456651	0.88	2.1e-02	Click!
Nr4a3	chr4_48044008_48044162	1068	0.583345	0.85	3.2e-02	Click!
Nr4a3	chr4_48045019_48045175	56	0.980703	0.80	5.6e-02	Click!
Nr4a3	chr4_48045892_48046043	736	0.721413	0.73	1.0e-01	Click!

Activity of the Nr4a3 motif across conditions

Conditions sorted by the z-value of the Nr4a3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr8_125976536_125976742	2.25	Kcnk1	potassium channel, subfamily K, member 1	18531	0.19
chr15_25435984_25436493	2.10	Gm48956	predicted gene, 48956	9402	0.16
chr10_99600138_99600289	1.28	Gm20110	predicted gene, 20110	8958	0.19
chr8_45691473_45691656	1.14	Sorbs2	sorbin and SH3 domain containing 2	3227	0.28
chr8_123978504_123978907	1.09	Abcb10	ATP-binding cassette, sub-family B (MDR/TAP), member 10	4417	0.12
chr6_119487729_119487894	1.05	Fbxl14	F-box and leucine-rich repeat protein 14	8143	0.21
chr8_24506282_24506451	1.02	9130214F15Rik	RIKEN cDNA 9130214F15 gene	64	0.97
chr5_93296317_93296483	1.02	Ccng2	cyclin G2	27692	0.16
chr17_81389463_81389664	1.01	Gm50044	predicted gene, 50044	18730	0.23
chr4_129191808_129191992	1.00	Yars	tyrosyl-tRNA synthetase	1998	0.2
chr1_187313973_187314152	0.99	Gm38155	predicted gene, 38155	63407	0.1
chr19_3650560_3650722	0.98	Lrp5	low density lipoprotein receptor-related protein 5	34849	0.1
chr1_79466047_79466371	0.96	Scg2	secretogranin II	26089	0.18
chr13_54583316_54583476	0.95	Arl10	ADP-ribosylation factor-like 10	4584	0.11
chr9_122018172_122018323	0.94	Gm47117	predicted gene, 47117	6107	0.11
chr3_100536474_100536643	0.94	Gm42868	predicted gene 42868	39129	0.11
chr3_52646413_52646568	0.88	Gm10293	predicted pseudogene 10293	33655	0.18
chr16_34746212_34746363	0.82	Mylk	myosin, light polypeptide kinase	1077	0.6
chr12_26387378_26387859	0.82	Rnf144a	ring finger protein 144A	18829	0.15
chr5_145864595_145865130	0.81	Cyp3a11	cytochrome P450, family 3, subfamily a, polypeptide 11	11829	0.16
chr4_134722177_134722332	0.81	Man1c1	mannosidase, alpha, class 1C, member 1	17964	0.18
chr14_51289185_51289366	0.81	Gm49245	predicted gene, 49245	11673	0.1
chr8_117637336_117637505	0.81	Sdr42e1	short chain dehydrogenase/reductase family 42E, member 1	34127	0.12
chr6_6183421_6183599	0.80	Slc25a13	solute carrier family 25 (mitochondrial carrier, adenine nucleotide translocator), member 13	7809	0.26
chr9_65191450_65191617	0.80	Parp16	poly (ADP-ribose) polymerase family, member 16	3820	0.14
chr2_167877367_167877523	0.80	Gm14319	predicted gene 14319	18860	0.16
chr1_179632334_179632515	0.78	Sccpdh	saccharopine dehydrogenase (putative)	35786	0.14
chr8_127515714_127515885	0.76	Gm6921	predicted pseudogene 6921	45636	0.17
chr2_163598624_163598794	0.76	Ttpal	tocopherol (alpha) transfer protein-like	3605	0.18
chrX_85053601_85053753	0.75	Dmd	dystrophin, muscular dystrophy	5264	0.33
chr10_75033725_75033908	0.74	Gm40692	predicted gene, 40692	529	0.63
chr3_85273227_85273668	0.73	1700036G14Rik	RIKEN cDNA 1700036G14 gene	44072	0.16
chr5_56910070_56910250	0.73	Gm23896	predicted gene, 23896	174070	0.03
chr18_20936854_20937178	0.73	Rnf125	ring finger protein 125	7609	0.22
chr10_42194110_42194261	0.72	Foxo3	forkhead box O3	64181	0.12
chr16_79059250_79059443	0.72	Tmprss15	transmembrane protease, serine 15	31746	0.22
chr12_29257874_29258025	0.72	Gm6989	predicted gene 6989	59619	0.14
chr6_62934342_62934493	0.72	Gm5001	predicted gene 5001	5271	0.31
chr7_24504957_24505109	0.71	Zfp428	zinc finger protein 428	1973	0.15
chr4_145279031_145279214	0.71	Tnfrsf1b	tumor necrosis factor receptor superfamily, member 1b	32252	0.14
chr2_163616887_163617081	0.70	Ttpal	tocopherol (alpha) transfer protein-like	5464	0.15
chr10_60733446_60733765	0.69	Slc29a3	solute carrier family 29 (nucleoside transporters), member 3	9289	0.21
chr14_19710131_19710282	0.69	Gm49341	predicted gene, 49341	12997	0.13
chr4_135746130_135746372	0.69	Gm12988	predicted gene 12988	10444	0.12
chr1_36525855_36526032	0.69	Gm38033	predicted gene, 38033	2294	0.14
chr10_84907603_84907783	0.69	Ric8b	RIC8 guanine nucleotide exchange factor B	9923	0.24
chr14_66521966_66522122	0.68	Gm23899	predicted gene, 23899	69651	0.11
chr10_79616142_79616293	0.68	C2cd4c	C2 calcium-dependent domain containing 4C	2192	0.15
chr1_51996762_51997232	0.68	Stat4	signal transducer and activator of transcription 4	9849	0.17
chr5_90894238_90894431	0.67	Gm22816	predicted gene, 22816	954	0.41
chr14_25295396_25295547	0.67	Gm26660	predicted gene, 26660	83164	0.08
chr19_30171407_30171581	0.67	Gldc	glycine decarboxylase	3935	0.23
chr18_15330500_15330684	0.65	E430002N23Rik	RIKEN cDNA E430002N23 gene	17893	0.18
chr2_166637694_166637887	0.65	Prex1	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1	1178	0.52
chr17_45322333_45322491	0.64	Cdc5l	cell division cycle 5-like (S. pombe)	93272	0.06
chr8_25819139_25819316	0.64	Ash2l	ASH2 like histone lysine methyltransferase complex subunit	4348	0.13
chr5_76297411_76297591	0.64	Gm43658	predicted gene 43658	4274	0.14
chr2_33369566_33369732	0.64	Ralgps1	Ral GEF with PH domain and SH3 binding motif 1	1780	0.3
chr19_5880801_5880961	0.64	Slc25a45	solute carrier family 25, member 45	2225	0.13
chr3_18463182_18463725	0.63	Gm30667	predicted gene, 30667	2199	0.33
chr1_133933859_133934320	0.62	Prelp	proline arginine-rich end leucine-rich repeat	12675	0.13
chr15_102177030_102177199	0.62	Csad	cysteine sulfinic acid decarboxylase	1905	0.2
chr10_28166717_28166892	0.61	Gm22370	predicted gene, 22370	47317	0.17
chr8_103417794_103417953	0.61	1600027J07Rik	RIKEN cDNA 1600027J07 gene	70339	0.12
chr13_114974629_114975014	0.61	Gm47776	predicted gene, 47776	39753	0.15
chr13_56477354_56477672	0.60	Il9	interleukin 9	4733	0.19
chr6_136469608_136469798	0.60	Gm6728	predicted gene 6728	17483	0.12
chr11_5917118_5917412	0.60	Gm11967	predicted gene 11967	1950	0.2
chr1_134293960_134294142	0.60	Myog	myogenin	4062	0.15
chr1_155158041_155158192	0.60	Stx6	syntaxin 6	599	0.68
chr15_96031527_96031698	0.59	D030018L15Rik	RIKEN cDNA D030018L15 gene	23213	0.19
chr16_91833643_91834213	0.59	Itsn1	intersectin 1 (SH3 domain protein 1A)	5771	0.19
chr12_41208691_41208865	0.59	Gm47376	predicted gene, 47376	139312	0.04
chr19_4700355_4700506	0.59	Gm960	predicted gene 960	1762	0.22
chr16_95673938_95674224	0.58	Ets2	E26 avian leukemia oncogene 2, 3' domain	27994	0.19
chr7_109599227_109599378	0.58	Denn2b	DENN domain containing 2B	3363	0.22
chr10_81417531_81417694	0.57	Mir1191b	microRNA 1191b	1315	0.18
chr1_130763367_130763536	0.57	Gm28856	predicted gene 28856	2933	0.14
chr8_84069298_84069478	0.57	C330011M18Rik	RIKEN cDNA C330011M18 gene	2101	0.12
chr5_92134368_92134534	0.56	Uso1	USO1 vesicle docking factor	3487	0.15
chr19_5567308_5567477	0.56	Ap5b1	adaptor-related protein complex 5, beta 1 subunit	633	0.46
chr18_31966444_31966632	0.56	Lims2	LIM and senescent cell antigen like domains 2	10205	0.13
chr2_118883051_118883401	0.55	Ivd	isovaleryl coenzyme A dehydrogenase	6793	0.14
chr9_77847197_77847348	0.55	Gm19572	predicted gene, 19572	4436	0.16
chr11_26592820_26593046	0.54	Gm6899	predicted gene 6899	293	0.76
chr2_167799424_167799897	0.54	9230111E07Rik	RIKEN cDNA 9230111E07 gene	17607	0.14
chr1_73901414_73901565	0.54	Tns1	tensin 1	26728	0.15
chr1_156074597_156074881	0.54	Tor1aip2	torsin A interacting protein 2	11526	0.17
chr13_14191910_14192117	0.54	Arid4b	AT rich interactive domain 4B (RBP1-like)	836	0.59
chr5_115475861_115476388	0.54	Sirt4	sirtuin 4	3814	0.1
chr8_25750561_25750717	0.54	Ddhd2	DDHD domain containing 2	789	0.44
chr12_59191626_59191786	0.53	Mia2	MIA SH3 domain ER export factor 2	12193	0.14
chr5_140171802_140172150	0.53	Mad1l1	MAD1 mitotic arrest deficient 1-like 1	2683	0.24
chr11_97836691_97836945	0.53	Lasp1	LIM and SH3 protein 1	3394	0.12
chr13_43252482_43252652	0.53	Gfod1	glucose-fructose oxidoreductase domain containing 1	50838	0.13
chr4_124737570_124737747	0.52	Gm24721	predicted gene, 24721	1819	0.16
chr10_43487752_43488061	0.52	Bend3	BEN domain containing 3	2672	0.19
chr11_117780625_117780787	0.52	Tmc6	transmembrane channel-like gene family 6	48	0.93
chr4_150732960_150733140	0.52	Gm16079	predicted gene 16079	54258	0.11
chr19_6251158_6251334	0.52	Atg2a	autophagy related 2A	242	0.81
chr1_62709908_62710059	0.52	Nrp2	neuropilin 2	6281	0.18
chr13_54439539_54439690	0.52	Thoc3	THO complex 3	29174	0.12
chr18_35256811_35256978	0.51	Ctnna1	catenin (cadherin associated protein), alpha 1	4573	0.19
chr9_111440393_111440743	0.51	Dclk3	doublecortin-like kinase 3	1487	0.42
chr16_3843876_3844135	0.51	Zfp174	zinc finger protein 174	3263	0.13
chr11_83850528_83850683	0.51	Hnf1b	HNF1 homeobox B	250	0.85
chr2_160805166_160805505	0.51	Gm11447	predicted gene 11447	40278	0.11
chr11_78972853_78973033	0.51	Lgals9	lectin, galactose binding, soluble 9	2613	0.27
chr1_153307781_153308161	0.50	Gm8818	predicted pseudogene 8818	2539	0.25
chr2_25708935_25709097	0.49	A230005M16Rik	RIKEN cDNA A230005M16 gene	700	0.42
chr4_144957863_144958036	0.49	Gm38074	predicted gene, 38074	899	0.6
chr19_33098081_33098289	0.49	Gm29946	predicted gene, 29946	24462	0.18
chr19_40218990_40219184	0.49	Pdlim1	PDZ and LIM domain 1 (elfin)	4269	0.17
chr2_43513507_43513674	0.48	Gm13464	predicted gene 13464	5808	0.3
chr6_39796421_39796591	0.48	Mrps33	mitochondrial ribosomal protein S33	9536	0.17
chr2_166678201_166678352	0.48	Gm23152	predicted gene, 23152	23134	0.17
chr10_84477716_84477877	0.48	4930463O16Rik	RIKEN cDNA 4930463O16 gene	10497	0.12
chr19_38709785_38709951	0.47	Gm8717	predicted gene 8717	5544	0.21
chr11_88574733_88574900	0.47	Msi2	musashi RNA-binding protein 2	15331	0.24
chrX_160424988_160425139	0.47	Adgrg2	adhesion G protein-coupled receptor G2	2229	0.34
chr17_26702508_26702992	0.47	Crebrf	CREB3 regulatory factor	12900	0.14
chr3_52469938_52470147	0.47	Gm38098	predicted gene, 38098	44634	0.14
chr3_69543290_69543467	0.47	Ppm1l	protein phosphatase 1 (formerly 2C)-like	946	0.58
chr18_4956609_4956805	0.47	Svil	supervillin	34981	0.22
chr14_100224229_100224566	0.46	Gm16260	predicted gene 16260	4911	0.22
chr4_154247269_154247441	0.46	Megf6	multiple EGF-like-domains 6	1941	0.28
chr1_121321522_121321673	0.46	Insig2	insulin induced gene 2	1594	0.33
chr1_157084475_157084641	0.46	Tex35	testis expressed 35	23830	0.14
chr6_71989276_71989427	0.46	Gm26628	predicted gene, 26628	25576	0.11
chr13_46161900_46162051	0.46	Gm10113	predicted gene 10113	29071	0.21
chr3_10282975_10283159	0.45	Fabp12	fatty acid binding protein 12	18107	0.09
chr3_104568490_104568648	0.45	Gm26091	predicted gene, 26091	32670	0.1
chr1_118448989_118449484	0.45	Gm26080	predicted gene, 26080	4249	0.15
chr2_34486208_34486368	0.45	Mapkap1	mitogen-activated protein kinase associated protein 1	41941	0.13
chr1_91899152_91899309	0.45	Gm37600	predicted gene, 37600	17030	0.18
chr1_91095685_91095922	0.45	Lrrfip1	leucine rich repeat (in FLII) interacting protein 1	15411	0.18
chr1_20618287_20618471	0.45	Pkhd1	polycystic kidney and hepatic disease 1	315	0.9
chr2_173162438_173162602	0.44	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	9438	0.17
chr7_102132512_102132682	0.44	Chrna10	cholinergic receptor, nicotinic, alpha polypeptide 10	15769	0.1
chr12_80126455_80126626	0.44	2310015A10Rik	RIKEN cDNA 2310015A10 gene	5401	0.14
chr4_15327477_15327645	0.44	Gm24317	predicted gene, 24317	55587	0.13
chr19_10041963_10042141	0.44	Fads3	fatty acid desaturase 3	320	0.83
chr6_119681588_119681760	0.43	Erc1	ELKS/RAB6-interacting/CAST family member 1	59569	0.13
chr6_72604103_72604254	0.43	Retsat	retinol saturase (all trans retinol 13,14 reductase)	195	0.84
chr11_46084943_46085145	0.43	Mir8100	microRNA 8100	17226	0.12
chr16_10981270_10981624	0.43	Litaf	LPS-induced TN factor	5868	0.12
chr7_134192391_134192592	0.43	Adam12	a disintegrin and metallopeptidase domain 12 (meltrin alpha)	19547	0.21
chr17_68285429_68285617	0.43	L3mbtl4	L3MBTL4 histone methyl-lysine binding protein	11726	0.26
chr17_65931229_65931442	0.43	Twsg1	twisted gastrulation BMP signaling modulator 1	4926	0.15
chr3_100189024_100189191	0.43	Gdap2	ganglioside-induced differentiation-associated-protein 2	5473	0.23
chr9_108858778_108859092	0.43	Slc26a6	solute carrier family 26, member 6	3273	0.12
chr1_59157472_59157626	0.43	Mpp4	membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)	1112	0.34
chr1_182125404_182125574	0.43	Srp9	signal recognition particle 9	708	0.61
chr6_99666342_99666493	0.43	Eif4e3	eukaryotic translation initiation factor 4E member 3	354	0.48
chr3_145561026_145561180	0.42	Znhit6	zinc finger, HIT type 6	15102	0.19
chr4_136018964_136019115	0.42	Gm24362	predicted gene, 24362	553	0.57
chr7_100077379_100077530	0.42	Pold3	polymerase (DNA-directed), delta 3, accessory subunit	12583	0.16
chr18_57029725_57029909	0.42	C330018D20Rik	RIKEN cDNA C330018D20 gene	54449	0.12
chr5_140107803_140107986	0.41	Gm16121	predicted gene 16121	6695	0.16
chr4_89526966_89527117	0.41	Gm12608	predicted gene 12608	82397	0.09
chr11_94158519_94158921	0.41	B230206L02Rik	RIKEN cDNA B230206L02 gene	23060	0.17
chr10_59784742_59784904	0.41	Gm17059	predicted gene 17059	15431	0.14
chr3_130692655_130693111	0.41	Ostc	oligosaccharyltransferase complex subunit (non-catalytic)	3739	0.17
chr7_45973330_45973912	0.41	Abcc6	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	302	0.76
chr2_169075125_169075304	0.40	Gm26469	predicted gene, 26469	14094	0.19
chr15_88830094_88830418	0.40	Gm23144	predicted gene, 23144	5044	0.15
chr12_29136516_29136667	0.40	Gm31333	predicted gene, 31333	2576	0.33
chr4_145054462_145054637	0.40	Vps13d	vacuolar protein sorting 13D	406	0.89
chr6_17469322_17469539	0.40	Met	met proto-oncogene	5323	0.23
chr9_46238922_46239117	0.40	Apoa4	apolipoprotein A-IV	1677	0.17
chr10_99207689_99207863	0.40	Poc1b	POC1 centriolar protein B	14884	0.11
chr17_11752805_11752972	0.40	Gm10513	predicted gene 10513	20543	0.26
chr15_81337946_81338137	0.40	Slc25a17	solute carrier family 25 (mitochondrial carrier, peroxisomal membrane protein), member 17	6116	0.16
chr7_136883017_136883173	0.40	Mgmt	O-6-methylguanine-DNA methyltransferase	11519	0.23
chr9_88355859_88356010	0.40	Nt5e	5' nucleotidase, ecto	247	0.9
chr6_37592493_37592657	0.40	Gm7463	predicted gene 7463	51161	0.14
chrX_7766214_7766424	0.39	Tfe3	transcription factor E3	1667	0.18
chr8_10914649_10914809	0.39	3930402G23Rik	RIKEN cDNA 3930402G23 gene	13715	0.09
chr15_82165521_82165825	0.39	Srebf2	sterol regulatory element binding factor 2	17648	0.09
chr16_23108839_23109021	0.39	Snord2	small nucleolar RNA, C/D box 2	23	0.76
chr3_87030981_87031137	0.39	Gm8869	predicted gene 8869	7176	0.14
chr7_143498695_143498856	0.38	Phlda2	pleckstrin homology like domain, family A, member 2	3766	0.14
chr5_73264643_73264803	0.38	Gm34411	predicted gene, 34411	1294	0.28
chr18_65097598_65097767	0.38	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	14628	0.23
chr19_46714979_46715130	0.38	As3mt	arsenic (+3 oxidation state) methyltransferase	3082	0.19
chr5_53078478_53078847	0.38	Slc34a2	solute carrier family 34 (sodium phosphate), member 2	29309	0.14
chr4_58546190_58546357	0.38	Lpar1	lysophosphatidic acid receptor 1	2128	0.33
chr9_63668708_63668859	0.38	Smad3	SMAD family member 3	2236	0.33
chr7_14425285_14425519	0.38	Sult2a8	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8	11045	0.16
chr6_99271808_99271987	0.38	Foxp1	forkhead box P1	5365	0.31
chr3_37634750_37634916	0.38	Spry1	sprouty RTK signaling antagonist 1	5114	0.12
chr15_27525366_27525772	0.38	B230362B09Rik	RIKEN cDNA B230362B09 gene	21657	0.15
chr1_190156610_190156822	0.38	Gm28172	predicted gene 28172	11954	0.18
chr5_96458803_96458986	0.38	Gm33050	predicted gene, 33050	1151	0.56
chr2_44920626_44920948	0.37	Gtdc1	glycosyltransferase-like domain containing 1	6362	0.29
chr8_126723593_126723744	0.37	Gm45805	predicted gene 45805	34666	0.19
chr6_128333409_128333573	0.37	Tulp3	tubby-like protein 3	7944	0.07
chr11_109478088_109478523	0.37	Slc16a6	solute carrier family 16 (monocarboxylic acid transporters), member 6	4707	0.13
chr18_75891950_75892137	0.37	Zbtb7c	zinc finger and BTB domain containing 7C	71828	0.11
chr14_54723804_54723977	0.37	Cebpe	CCAAT/enhancer binding protein (C/EBP), epsilon	11716	0.09

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr4a3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0035865	response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.1	0.4	GO:0034773	histone H4-K20 trimethylation(GO:0034773)
0.1	0.4	GO:0072180	mesonephric duct morphogenesis(GO:0072180)
0.1	0.4	GO:0009169	ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.1	0.4	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.1	0.4	GO:0060075	regulation of resting membrane potential(GO:0060075)
0.1	0.2	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.1	0.2	GO:0043465	regulation of fermentation(GO:0043465) regulation of NAD metabolic process(GO:1902688) regulation of glucose catabolic process to lactate via pyruvate(GO:1904023)
0.1	0.4	GO:0001922	B-1 B cell homeostasis(GO:0001922)
0.1	0.2	GO:0043490	malate-aspartate shuttle(GO:0043490)
0.1	0.2	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.1	0.2	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.1	0.3	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.1	0.2	GO:0006438	valyl-tRNA aminoacylation(GO:0006438)
0.1	0.2	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process(GO:1902109)
0.1	0.2	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
0.1	0.2	GO:1900108	negative regulation of nodal signaling pathway(GO:1900108)
0.1	0.2	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.3	GO:0010694	positive regulation of alkaline phosphatase activity(GO:0010694)
0.0	0.1	GO:0035672	oligopeptide transmembrane transport(GO:0035672)
0.0	0.1	GO:0034287	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.4	GO:0090161	Golgi ribbon formation(GO:0090161)
0.0	0.0	GO:1902534	single-organism membrane invagination(GO:1902534)
0.0	0.1	GO:0071673	positive regulation of smooth muscle cell chemotaxis(GO:0071673)
0.0	0.2	GO:0010529	regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.0	0.2	GO:0043097	pyrimidine-containing compound salvage(GO:0008655) pyrimidine nucleoside salvage(GO:0043097)
0.0	0.3	GO:0071044	histone mRNA catabolic process(GO:0071044)
0.0	0.1	GO:0052422	modulation of catalytic activity in other organism involved in symbiotic interaction(GO:0052203) modulation by host of symbiont catalytic activity(GO:0052422)
0.0	0.1	GO:0090365	regulation of mRNA modification(GO:0090365)
0.0	0.0	GO:0002432	granuloma formation(GO:0002432)
0.0	0.4	GO:0060394	negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.0	0.1	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.1	GO:0001712	ectodermal cell fate commitment(GO:0001712)
0.0	0.1	GO:0034197	acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197)
0.0	0.1	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0016554	cytidine to uridine editing(GO:0016554)
0.0	0.1	GO:1900747	negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.0	0.1	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.2	GO:0060297	regulation of sarcomere organization(GO:0060297)
0.0	0.1	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.0	0.1	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	0.1	GO:0010760	negative regulation of macrophage chemotaxis(GO:0010760)
0.0	0.1	GO:0042998	positive regulation of Golgi to plasma membrane protein transport(GO:0042998)
0.0	0.1	GO:0014735	regulation of muscle atrophy(GO:0014735)
0.0	0.2	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.2	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.1	GO:0048549	positive regulation of pinocytosis(GO:0048549)
0.0	0.1	GO:0019464	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.1	GO:0070213	protein auto-ADP-ribosylation(GO:0070213)
0.0	0.1	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.1	GO:1903679	regulation of cap-independent translational initiation(GO:1903677) positive regulation of cap-independent translational initiation(GO:1903679) regulation of cytoplasmic translational initiation(GO:1904688) positive regulation of cytoplasmic translational initiation(GO:1904690)
0.0	0.2	GO:0006991	response to sterol depletion(GO:0006991) SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0	0.1	GO:0009597	detection of virus(GO:0009597)
0.0	0.2	GO:0006703	estrogen biosynthetic process(GO:0006703)
0.0	0.5	GO:0042572	retinol metabolic process(GO:0042572)
0.0	0.1	GO:0050717	positive regulation of interleukin-1 alpha secretion(GO:0050717)
0.0	0.1	GO:1903898	negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.0	0.1	GO:0019853	L-ascorbic acid biosynthetic process(GO:0019853)
0.0	0.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.1	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:0007525	somatic muscle development(GO:0007525)
0.0	0.1	GO:0070947	neutrophil mediated killing of fungus(GO:0070947)
0.0	0.1	GO:0010991	negative regulation of SMAD protein complex assembly(GO:0010991)
0.0	0.1	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.0	0.1	GO:1990791	dorsal root ganglion development(GO:1990791)
0.0	0.1	GO:0034080	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	0.1	GO:1904970	brush border assembly(GO:1904970)
0.0	0.1	GO:0071680	response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
0.0	0.0	GO:2001046	positive regulation of integrin-mediated signaling pathway(GO:2001046)
0.0	0.0	GO:0090232	positive regulation of spindle checkpoint(GO:0090232)
0.0	0.1	GO:0033159	negative regulation of protein import into nucleus, translocation(GO:0033159)
0.0	0.0	GO:0071492	cellular response to UV-A(GO:0071492)
0.0	0.1	GO:0006551	leucine metabolic process(GO:0006551)
0.0	0.3	GO:0034389	lipid particle organization(GO:0034389)
0.0	0.2	GO:0015858	nucleoside transport(GO:0015858)
0.0	0.6	GO:1900026	positive regulation of substrate adhesion-dependent cell spreading(GO:1900026)
0.0	0.1	GO:0000972	transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
0.0	0.1	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.4	GO:0044804	nucleophagy(GO:0044804)
0.0	0.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.0	GO:0032484	Ral protein signal transduction(GO:0032484)
0.0	0.0	GO:0019249	lactate biosynthetic process from pyruvate(GO:0019244) lactate biosynthetic process(GO:0019249)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:0021914	negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning(GO:0021914)
0.0	0.1	GO:0046061	dATP catabolic process(GO:0046061)
0.0	0.1	GO:0070295	renal water absorption(GO:0070295)
0.0	0.1	GO:0036295	cellular response to increased oxygen levels(GO:0036295) cellular response to hyperoxia(GO:0071455)
0.0	0.1	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.1	GO:1903215	negative regulation of protein targeting to mitochondrion(GO:1903215)
0.0	0.1	GO:2000323	negative regulation of glucocorticoid receptor signaling pathway(GO:2000323)
0.0	0.0	GO:0061502	early endosome to recycling endosome transport(GO:0061502)
0.0	0.1	GO:0046959	habituation(GO:0046959)
0.0	0.0	GO:0021524	visceral motor neuron differentiation(GO:0021524)
0.0	0.1	GO:0035526	retrograde transport, plasma membrane to Golgi(GO:0035526)
0.0	0.3	GO:0046325	negative regulation of glucose import(GO:0046325)
0.0	0.1	GO:0048003	antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.0	0.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.1	GO:0006114	glycerol biosynthetic process(GO:0006114)
0.0	0.0	GO:0090310	negative regulation of methylation-dependent chromatin silencing(GO:0090310)
0.0	0.0	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.1	GO:0046473	phosphatidic acid metabolic process(GO:0046473)
0.0	0.2	GO:0072311	renal filtration cell differentiation(GO:0061318) glomerular epithelium development(GO:0072010) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
0.0	0.3	GO:0032011	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:2001137	positive regulation of endocytic recycling(GO:2001137)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0036015	response to interleukin-3(GO:0036015) cellular response to interleukin-3(GO:0036016)
0.0	0.1	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.1	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.0	GO:1902953	positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.0	0.2	GO:0031507	heterochromatin assembly(GO:0031507)
0.0	0.1	GO:0042045	epithelial fluid transport(GO:0042045)
0.0	0.2	GO:2000781	positive regulation of double-strand break repair(GO:2000781)
0.0	0.1	GO:0090435	protein localization to nuclear envelope(GO:0090435)
0.0	0.0	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.0	GO:1901673	regulation of mitotic spindle assembly(GO:1901673)
0.0	0.0	GO:2000275	regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.0	0.1	GO:0006451	selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0	0.0	GO:0008228	opsonization(GO:0008228)
0.0	0.1	GO:0042574	retinal metabolic process(GO:0042574)
0.0	0.1	GO:0036089	cleavage furrow formation(GO:0036089)
0.0	0.0	GO:0046391	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0	0.1	GO:0031119	tRNA pseudouridine synthesis(GO:0031119)
0.0	0.0	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
0.0	0.1	GO:0006007	glucose catabolic process(GO:0006007)
0.0	0.2	GO:0055012	ventricular cardiac muscle cell differentiation(GO:0055012)
0.0	0.1	GO:2000766	negative regulation of cytoplasmic translation(GO:2000766)
0.0	0.3	GO:0032981	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.0	GO:0036444	calcium ion transmembrane import into mitochondrion(GO:0036444)
0.0	0.0	GO:0065001	specification of axis polarity(GO:0065001)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.1	GO:2000741	positive regulation of mesenchymal stem cell differentiation(GO:2000741)
0.0	0.0	GO:0045074	interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.1	GO:0051352	negative regulation of ligase activity(GO:0051352)
0.0	0.0	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0071635	negative regulation of transforming growth factor beta production(GO:0071635)
0.0	0.1	GO:2001268	negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.0	0.0	GO:0033505	floor plate morphogenesis(GO:0033505)
0.0	0.3	GO:0071173	mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.0	0.1	GO:1902373	negative regulation of mRNA catabolic process(GO:1902373)
0.0	0.1	GO:0021999	neural plate anterior/posterior regionalization(GO:0021999)
0.0	0.4	GO:0010824	regulation of centrosome duplication(GO:0010824)
0.0	0.0	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.1	GO:0030388	fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.0	0.0	GO:0044339	canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
0.0	0.0	GO:0034165	positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0	0.0	GO:0060468	prevention of polyspermy(GO:0060468)
0.0	0.2	GO:0003301	physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0	0.0	GO:0042628	mating plug formation(GO:0042628) post-mating behavior(GO:0045297)
0.0	0.0	GO:0031296	B cell costimulation(GO:0031296)
0.0	0.0	GO:0010288	response to lead ion(GO:0010288)
0.0	0.1	GO:1902018	negative regulation of cilium assembly(GO:1902018)
0.0	0.1	GO:0006297	nucleotide-excision repair, DNA gap filling(GO:0006297)
0.0	0.1	GO:0048254	snoRNA localization(GO:0048254)
0.0	0.2	GO:0014733	regulation of skeletal muscle adaptation(GO:0014733)
0.0	0.0	GO:0061084	negative regulation of protein refolding(GO:0061084)
0.0	0.1	GO:1902474	positive regulation of protein localization to synapse(GO:1902474)
0.0	0.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.1	GO:0048280	vesicle fusion with Golgi apparatus(GO:0048280)
0.0	0.0	GO:0015888	thiamine transport(GO:0015888)
0.0	0.1	GO:0035269	protein O-linked mannosylation(GO:0035269)
0.0	0.0	GO:1903690	negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.0	0.1	GO:0070072	vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.0	0.1	GO:0042921	glucocorticoid receptor signaling pathway(GO:0042921)
0.0	0.0	GO:0036515	serotonergic neuron axon guidance(GO:0036515)
0.0	0.0	GO:0090166	Golgi disassembly(GO:0090166)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.0	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.1	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.0	GO:0014858	positive regulation of skeletal muscle cell proliferation(GO:0014858)
0.0	0.1	GO:0033127	regulation of histone phosphorylation(GO:0033127)
0.0	0.0	GO:0000189	MAPK import into nucleus(GO:0000189)
0.0	0.0	GO:0002414	immunoglobulin transcytosis in epithelial cells(GO:0002414)
0.0	0.0	GO:2000297	negative regulation of synapse maturation(GO:2000297)
0.0	0.0	GO:0035441	cell migration involved in vasculogenesis(GO:0035441)
0.0	0.1	GO:1900042	positive regulation of interleukin-2 secretion(GO:1900042)
0.0	0.0	GO:0003347	epicardial cell to mesenchymal cell transition(GO:0003347)
0.0	0.1	GO:0098814	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0	0.0	GO:0030202	heparin metabolic process(GO:0030202)
0.0	0.2	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.0	GO:0071921	establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
0.0	0.0	GO:0002905	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0	0.2	GO:0015732	prostaglandin transport(GO:0015732)
0.0	0.0	GO:0046077	dUDP biosynthetic process(GO:0006227) dTTP biosynthetic process(GO:0006235) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) dTTP metabolic process(GO:0046075) dUDP metabolic process(GO:0046077)
0.0	0.1	GO:0016572	histone phosphorylation(GO:0016572)
0.0	0.1	GO:0090370	negative regulation of cholesterol efflux(GO:0090370)
0.0	0.0	GO:0021827	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0036336	dendritic cell migration(GO:0036336)
0.0	0.2	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:0070314	G1 to G0 transition(GO:0070314)
0.0	0.0	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.0	0.0	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.0	GO:0036151	phosphatidylcholine acyl-chain remodeling(GO:0036151)
0.0	0.2	GO:0033622	integrin activation(GO:0033622)
0.0	0.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
0.0	0.0	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.0	GO:0010966	regulation of phosphate transport(GO:0010966)
0.0	0.0	GO:0001547	antral ovarian follicle growth(GO:0001547)
0.0	0.1	GO:0050957	equilibrioception(GO:0050957)
0.0	0.0	GO:0045343	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0	0.0	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.0	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.0	0.1	GO:0032754	positive regulation of interleukin-5 production(GO:0032754)
0.0	0.2	GO:0052696	flavonoid biosynthetic process(GO:0009813) flavonoid glucuronidation(GO:0052696)
0.0	0.1	GO:0015846	polyamine transport(GO:0015846) polyamine transmembrane transport(GO:1902047) regulation of polyamine transmembrane transport(GO:1902267)
0.0	0.0	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.0	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.0	0.1	GO:0048245	eosinophil chemotaxis(GO:0048245)
0.0	0.0	GO:0070384	Harderian gland development(GO:0070384)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0005785	signal recognition particle receptor complex(GO:0005785)
0.1	0.3	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	0.2	GO:0000835	ER ubiquitin ligase complex(GO:0000835) Hrd1p ubiquitin ligase complex(GO:0000836)
0.0	0.2	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.1	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.1	GO:0030121	AP-1 adaptor complex(GO:0030121)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.4	GO:0005640	nuclear outer membrane(GO:0005640)
0.0	0.1	GO:0046691	intracellular canaliculus(GO:0046691)
0.0	0.1	GO:0034666	integrin alpha2-beta1 complex(GO:0034666)
0.0	0.1	GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex(GO:0070033)
0.0	0.1	GO:0097648	G-protein coupled receptor dimeric complex(GO:0038037) G-protein coupled receptor complex(GO:0097648)
0.0	0.1	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.1	GO:0090498	extrinsic component of Golgi membrane(GO:0090498)
0.0	0.1	GO:0030289	protein phosphatase 4 complex(GO:0030289)
0.0	0.1	GO:0070776	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0008282	ATP-sensitive potassium channel complex(GO:0008282)
0.0	0.2	GO:0045180	basal cortex(GO:0045180)
0.0	0.2	GO:0033179	proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0	0.1	GO:0000275	mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0	0.1	GO:0043259	laminin-10 complex(GO:0043259)
0.0	0.1	GO:0097443	sorting endosome(GO:0097443)
0.0	0.4	GO:0043034	costamere(GO:0043034)
0.0	0.2	GO:0005677	chromatin silencing complex(GO:0005677)
0.0	0.1	GO:0020018	ciliary pocket(GO:0020016) ciliary pocket membrane(GO:0020018)
0.0	0.1	GO:0005915	zonula adherens(GO:0005915)
0.0	0.5	GO:0097610	cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0	0.5	GO:0000407	pre-autophagosomal structure(GO:0000407)
0.0	0.1	GO:0032777	Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.0	0.3	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0005672	transcription factor TFIIA complex(GO:0005672)
0.0	0.1	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.1	GO:0030485	smooth muscle contractile fiber(GO:0030485)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.0	GO:0097513	myosin II filament(GO:0097513)
0.0	0.1	GO:0008091	spectrin(GO:0008091)
0.0	0.1	GO:0005683	U7 snRNP(GO:0005683)
0.0	0.1	GO:0001939	female pronucleus(GO:0001939)
0.0	0.1	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	0.1	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.1	GO:0071203	WASH complex(GO:0071203)
0.0	0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.4	GO:0008180	COP9 signalosome(GO:0008180)
0.0	0.2	GO:0005779	integral component of peroxisomal membrane(GO:0005779)
0.0	0.0	GO:0030891	VCB complex(GO:0030891)
0.0	0.1	GO:0034098	VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0	0.0	GO:1990246	uniplex complex(GO:1990246)
0.0	0.1	GO:0071014	post-mRNA release spliceosomal complex(GO:0071014)
0.0	0.1	GO:1990124	messenger ribonucleoprotein complex(GO:1990124)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0034388	Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.0	0.0	GO:0097441	basilar dendrite(GO:0097441)
0.0	0.1	GO:0031430	M band(GO:0031430)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.1	0.2	GO:0004832	valine-tRNA ligase activity(GO:0004832)
0.1	0.3	GO:0002134	UTP binding(GO:0002134) pyrimidine ribonucleoside binding(GO:0032551)
0.1	0.3	GO:0005047	signal recognition particle binding(GO:0005047)
0.1	0.2	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.1	0.2	GO:1904288	BAT3 complex binding(GO:1904288)
0.1	0.2	GO:0004083	bisphosphoglycerate 2-phosphatase activity(GO:0004083)
0.1	0.2	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.1	0.2	GO:0070915	lysophosphatidic acid receptor activity(GO:0070915)
0.1	0.2	GO:0015183	L-aspartate transmembrane transporter activity(GO:0015183)
0.1	0.1	GO:0017098	sulfonylurea receptor binding(GO:0017098)
0.0	0.1	GO:0015563	uptake transmembrane transporter activity(GO:0015563)
0.0	0.1	GO:0031800	type 3 metabotropic glutamate receptor binding(GO:0031800)
0.0	0.1	GO:0043546	molybdopterin cofactor binding(GO:0043546)
0.0	0.1	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.2	GO:0038100	nodal binding(GO:0038100)
0.0	0.2	GO:0004849	uridine kinase activity(GO:0004849)
0.0	0.4	GO:0016215	acyl-CoA desaturase activity(GO:0016215)
0.0	0.2	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0098748	clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.0	0.3	GO:0070097	delta-catenin binding(GO:0070097)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0005072	transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
0.0	0.3	GO:0002162	dystroglycan binding(GO:0002162)
0.0	0.2	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:1990188	euchromatin binding(GO:1990188)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.5	GO:0022842	leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.0	0.2	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.1	GO:0047105	aminobutyraldehyde dehydrogenase activity(GO:0019145) 4-trimethylammoniobutyraldehyde dehydrogenase activity(GO:0047105)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.1	GO:0004965	G-protein coupled GABA receptor activity(GO:0004965)
0.0	0.4	GO:0008253	5'-nucleotidase activity(GO:0008253)
0.0	0.2	GO:0003854	3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.0	0.1	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.1	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.2	GO:0031432	titin binding(GO:0031432)
0.0	0.1	GO:0019808	polyamine binding(GO:0019808)
0.0	0.1	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	0.1	GO:0016936	galactoside binding(GO:0016936)
0.0	0.1	GO:0070137	ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0098634	protein binding involved in cell-matrix adhesion(GO:0098634)
0.0	0.1	GO:0071209	U7 snRNA binding(GO:0071209)
0.0	0.1	GO:0004013	adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.0	0.3	GO:0097506	uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0	0.1	GO:0004385	guanylate kinase activity(GO:0004385)
0.0	0.0	GO:0034416	bisphosphoglycerate phosphatase activity(GO:0034416)
0.0	0.1	GO:0000182	rDNA binding(GO:0000182)
0.0	0.3	GO:0004806	triglyceride lipase activity(GO:0004806)
0.0	0.1	GO:0031730	CCR5 chemokine receptor binding(GO:0031730)
0.0	0.1	GO:0003708	retinoic acid receptor activity(GO:0003708)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.1	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.2	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.2	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.3	GO:0046961	proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.0	0.1	GO:0034618	arginine binding(GO:0034618)
0.0	0.3	GO:0004435	phosphatidylinositol phospholipase C activity(GO:0004435)
0.0	0.0	GO:0019959	interleukin-8 binding(GO:0019959)
0.0	0.1	GO:0032184	SUMO polymer binding(GO:0032184)
0.0	0.1	GO:0071253	connexin binding(GO:0071253)
0.0	0.0	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.1	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.1	GO:0042015	interleukin-20 binding(GO:0042015)
0.0	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.5	GO:0005484	SNAP receptor activity(GO:0005484)
0.0	0.0	GO:0016717	oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.0	0.0	GO:0038085	vascular endothelial growth factor binding(GO:0038085)
0.0	0.2	GO:0045236	CXCR chemokine receptor binding(GO:0045236)
0.0	0.1	GO:0071723	lipopeptide binding(GO:0071723)
0.0	0.1	GO:0060228	phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
0.0	0.1	GO:0015254	glycerol transmembrane transporter activity(GO:0015168) glycerol channel activity(GO:0015254)
0.0	0.1	GO:0005095	GTPase inhibitor activity(GO:0005095)
0.0	0.1	GO:0003988	acetyl-CoA C-acyltransferase activity(GO:0003988)
0.0	0.2	GO:0005545	1-phosphatidylinositol binding(GO:0005545)
0.0	0.1	GO:0015016	[heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.0	0.0	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.0	GO:0032564	dATP binding(GO:0032564)
0.0	0.1	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0022889	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.0	0.1	GO:0005021	vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.0	0.1	GO:0015245	fatty acid transporter activity(GO:0015245)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0070290	N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
0.0	0.0	GO:0102007	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.0	GO:0009041	uridylate kinase activity(GO:0009041)
0.0	0.1	GO:0035473	lipase binding(GO:0035473)
0.0	0.1	GO:0018741	alkyl sulfatase activity(GO:0018741) endosulfan hemisulfate sulfatase activity(GO:0034889) endosulfan sulfate hydrolase activity(GO:0034902)
0.0	0.1	GO:0035671	enone reductase activity(GO:0035671)
0.0	0.1	GO:0017127	cholesterol transporter activity(GO:0017127)
0.0	0.0	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.2	GO:0031434	mitogen-activated protein kinase kinase binding(GO:0031434)
0.0	0.0	GO:0032558	adenyl deoxyribonucleotide binding(GO:0032558)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.0	GO:0004739	pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739)
0.0	0.1	GO:0046975	histone methyltransferase activity (H3-K36 specific)(GO:0046975)
0.0	0.2	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.7	GO:0005089	Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0	0.1	GO:0000339	RNA cap binding(GO:0000339)
0.0	0.1	GO:1990459	transferrin receptor binding(GO:1990459)
0.0	0.2	GO:0008137	NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.0	0.1	GO:0042979	ornithine decarboxylase regulator activity(GO:0042979)
0.0	0.0	GO:0004487	methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
0.0	0.1	GO:0043208	glycosphingolipid binding(GO:0043208)
0.0	0.2	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.6	PID RAC1 REG PATHWAY	Regulation of RAC1 activity
0.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.3	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.3	PID SMAD2 3PATHWAY	Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.1	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.5	PID AURORA B PATHWAY	Aurora B signaling
0.3	PID IL27 PATHWAY	IL27-mediated signaling events
0.0	PID ERBB4 PATHWAY	ErbB4 signaling events
0.2	PID IL3 PATHWAY	IL3-mediated signaling events
0.3	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.5	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling
0.2	PID EPHB FWD PATHWAY	EPHB forward signaling
0.2	PID SYNDECAN 2 PATHWAY	Syndecan-2-mediated signaling events
0.1	SA FAS SIGNALING	The TNF-type receptor Fas induces apoptosis on ligand binding.
0.0	PID GLYPICAN 1PATHWAY	Glypican 1 network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.5	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.0	0.4	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
0.0	0.5	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0	0.0	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.6	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	0.9	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
0.0	0.3	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
0.0	0.3	REACTOME SIGNALING BY NODAL	Genes involved in Signaling by NODAL
0.0	0.1	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.0	0.4	REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT	Genes involved in ABC-family proteins mediated transport
0.0	0.2	REACTOME RESOLUTION OF AP SITES VIA THE MULTIPLE NUCLEOTIDE PATCH REPLACEMENT PATHWAY	Genes involved in Resolution of AP sites via the multiple-nucleotide patch replacement pathway
0.0	0.1	REACTOME PASSIVE TRANSPORT BY AQUAPORINS	Genes involved in Passive Transport by Aquaporins
0.0	0.3	REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA	Genes involved in G beta:gamma signalling through PLC beta
0.0	0.2	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
0.0	0.3	REACTOME SIGNALING BY ROBO RECEPTOR	Genes involved in Signaling by Robo receptor
0.0	0.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.1	REACTOME IL 6 SIGNALING	Genes involved in Interleukin-6 signaling
0.0	0.1	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.1	REACTOME TRANSPORT OF ORGANIC ANIONS	Genes involved in Transport of organic anions
0.0	0.2	REACTOME ACTIVATION OF IRF3 IRF7 MEDIATED BY TBK1 IKK EPSILON	Genes involved in Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon
0.0	0.1	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.0	0.3	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
0.0	0.1	REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC	Genes involved in Regulation of ornithine decarboxylase (ODC)
0.0	0.1	REACTOME LIPOPROTEIN METABOLISM	Genes involved in Lipoprotein metabolism
0.0	0.1	REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS	Genes involved in Signal regulatory protein (SIRP) family interactions
0.0	0.3	REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION	Genes involved in Transport to the Golgi and subsequent modification
0.0	0.1	REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS	Genes involved in Elevation of cytosolic Ca2+ levels