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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Nr5a2

Z-value: 1.51

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Transcription factors associated with Nr5a2

Gene Symbol	Gene ID	Gene Info
Nr5a2 Ensembl NCBI MGI UniProt	ENSMUSG00000026398.8	nuclear receptor subfamily 5, group A, member 2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr1_136911239_136911410	Nr5a2	29259	0.182532	0.84	3.7e-02	Click!
chr1_136893539_136893740	Nr5a2	46944	0.132559	0.82	4.7e-02	Click!
chr1_136910524_136910904	Nr5a2	29869	0.180781	0.81	5.0e-02	Click!
chr1_136933160_136933350	Nr5a2	7328	0.241506	0.75	8.5e-02	Click!
chr1_136874160_136874323	Nr5a2	66342	0.087863	0.72	1.0e-01	Click!

Activity of the Nr5a2 motif across conditions

Conditions sorted by the z-value of the Nr5a2 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_182500736_182501185	1.61	Gm37069	predicted gene, 37069	6804	0.14
chr2_31476173_31476462	0.96	Ass1	argininosuccinate synthetase 1	6110	0.2
chr10_84418574_84418728	0.91	Nuak1	NUAK family, SNF1-like kinase, 1	21946	0.15
chr2_125617617_125617780	0.76	Cep152	centrosomal protein 152	7415	0.23
chr2_173158545_173158939	0.72	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	5660	0.18
chr10_24777725_24777876	0.70	Enpp3	ectonucleotide pyrophosphatase/phosphodiesterase 3	7205	0.23
chr11_7196610_7196788	0.69	Igfbp1	insulin-like growth factor binding protein 1	1083	0.48
chr5_66421556_66421781	0.64	Gm43792	predicted gene 43792	10458	0.16
chr17_47444308_47444531	0.60	1700001C19Rik	RIKEN cDNA 1700001C19 gene	7043	0.12
chr2_34486208_34486368	0.59	Mapkap1	mitogen-activated protein kinase associated protein 1	41941	0.13
chr13_51095199_51095382	0.58	Spin1	spindlin 1	5590	0.26
chr6_117297266_117297417	0.57	Rpl28-ps4	ribosomal protein L28, pseudogene 4	83275	0.08
chr3_18626956_18627107	0.57	Gm42944	predicted gene 42944	4869	0.23
chr8_105044924_105045225	0.55	Gm45725	predicted gene 45725	92	0.94
chr8_10935282_10935610	0.55	Gm45042	predicted gene 45042	5559	0.11
chr12_52442391_52442588	0.55	Gm47431	predicted gene, 47431	5636	0.23
chr7_73587321_73587472	0.54	Gm44734	predicted gene 44734	21552	0.09
chr10_8229677_8229834	0.54	Gm30906	predicted gene, 30906	53624	0.15
chr5_134456918_134457072	0.53	Gtf2ird1	general transcription factor II I repeat domain-containing 1	279	0.77
chr10_21447624_21447924	0.53	Gm48386	predicted gene, 48386	2138	0.25
chr18_3415919_3416074	0.52	Cul2	cullin 2	17888	0.15
chr8_33798912_33799096	0.51	Rbpms	RNA binding protein gene with multiple splicing	1790	0.29
chr19_30150086_30150237	0.50	Gldc	glycine decarboxylase	4930	0.21
chr2_69466274_69466471	0.50	Lrp2	low density lipoprotein receptor-related protein 2	42773	0.15
chr17_12392360_12392620	0.49	Plg	plasminogen	13831	0.16
chr6_72571781_72571932	0.49	Capg	capping protein (actin filament), gelsolin-like	15877	0.09
chr14_25516055_25516210	0.48	Zmiz1	zinc finger, MIZ-type containing 1	13477	0.15
chr17_12411169_12411345	0.48	Plg	plasminogen	32598	0.13
chr10_96235051_96235242	0.48	4930459C07Rik	RIKEN cDNA 4930459C07 gene	8939	0.2
chr8_119443050_119443280	0.47	Necab2	N-terminal EF-hand calcium binding protein 2	3554	0.18
chr1_51877379_51877530	0.47	Gm28323	predicted gene 28323	2154	0.26
chr9_48767602_48767753	0.46	Zbtb16	zinc finger and BTB domain containing 16	68268	0.11
chr6_141432376_141432556	0.46	Gm43958	predicted gene, 43958	9894	0.26
chr1_178219599_178219928	0.46	Desi2	desumoylating isopeptidase 2	31916	0.13
chr9_20741226_20741380	0.46	Olfm2	olfactomedin 2	5046	0.17
chr1_51774175_51774474	0.46	Myo1b	myosin IB	2112	0.33
chr5_150227352_150227751	0.45	Gm36378	predicted gene, 36378	16312	0.19
chr9_43622435_43622586	0.45	Gm29909	predicted gene, 29909	14326	0.17
chr2_163595110_163595261	0.45	Ttpal	tocopherol (alpha) transfer protein-like	7129	0.15
chr7_112294455_112294629	0.45	Mical2	microtubule associated monooxygenase, calponin and LIM domain containing 2	21487	0.25
chr4_145016736_145017043	0.44	Vps13d	vacuolar protein sorting 13D	32928	0.18
chr19_45310205_45310467	0.44	Gm28578	predicted gene 28578	754	0.62
chr15_11394606_11394765	0.43	Tars	threonyl-tRNA synthetase	2415	0.37
chr13_43253808_43253976	0.43	Gfod1	glucose-fructose oxidoreductase domain containing 1	49513	0.13
chr2_173159655_173159816	0.43	Pck1	phosphoenolpyruvate carboxykinase 1, cytosolic	6653	0.18
chr5_125325436_125325605	0.43	Scarb1	scavenger receptor class B, member 1	747	0.57
chr2_153580884_153581050	0.42	Nol4l	nucleolar protein 4-like	50996	0.1
chr2_172472866_172473017	0.42	Fam209	family with sequence similarity 209	421	0.78
chr4_19523139_19523419	0.42	Cpne3	copine III	20399	0.22
chr7_28732426_28732636	0.42	Fbxo17	F-box protein 17	31	0.95
chr15_102179533_102179684	0.41	Csad	cysteine sulfinic acid decarboxylase	253	0.85
chr14_73045910_73046229	0.41	Cysltr2	cysteinyl leukotriene receptor 2	3003	0.3
chr14_71963090_71963264	0.41	4930434J06Rik	RIKEN cDNA 4930434J06 gene	50086	0.18
chr11_98301768_98301944	0.41	Gm20644	predicted gene 20644	16474	0.09
chr1_156184131_156184502	0.41	Fam163a	family with sequence similarity 163, member A	20710	0.16
chr2_129337674_129337837	0.40	Gm25703	predicted gene, 25703	22276	0.09
chr10_5130565_5130739	0.40	Syne1	spectrin repeat containing, nuclear envelope 1	11876	0.22
chr5_114558713_114558889	0.40	Gm13790	predicted gene 13790	7512	0.16
chr17_12931620_12931776	0.40	Acat3	acetyl-Coenzyme A acetyltransferase 3	4016	0.09
chr4_141276769_141276920	0.39	Gm13056	predicted gene 13056	1595	0.24
chr10_77008035_77008232	0.39	Gm35721	predicted gene, 35721	436	0.75
chr16_29943589_29943740	0.39	Gm26569	predicted gene, 26569	2852	0.26
chr10_59784742_59784904	0.39	Gm17059	predicted gene 17059	15431	0.14
chr3_127103964_127104222	0.38	Ank2	ankyrin 2, brain	20769	0.14
chr9_26413705_26413886	0.38	Gm48373	predicted gene, 48373	27493	0.21
chr16_31567276_31567455	0.38	Gm34256	predicted gene, 34256	25855	0.14
chr14_59443633_59443793	0.38	Cab39l	calcium binding protein 39-like	2732	0.21
chr14_20148641_20148813	0.38	Kcnk5	potassium channel, subfamily K, member 5	3433	0.19
chr2_41790211_41790364	0.38	Lrp1b	low density lipoprotein-related protein 1B	1209	0.66
chr1_86998138_86998337	0.38	Gm37017	predicted gene, 37017	9967	0.13
chr10_66914376_66914558	0.38	1110002J07Rik	RIKEN cDNA 1110002J07 gene	3272	0.2
chr3_117862558_117862719	0.37	Snx7	sorting nexin 7	6183	0.21
chr8_122274769_122274938	0.37	Zfp469	zinc finger protein 469	5284	0.17
chr2_30759973_30760153	0.37	1700001O22Rik	RIKEN cDNA 1700001O22 gene	36601	0.09
chr5_92206260_92206413	0.37	U90926	cDNA sequence U90926	6014	0.11
chr9_65334133_65334359	0.37	Gm39363	predicted gene, 39363	1726	0.18
chr17_31861640_31861807	0.37	Sik1	salt inducible kinase 1	5919	0.17
chr14_65721753_65721925	0.36	Scara5	scavenger receptor class A, member 5	45362	0.14
chr1_102517589_102517767	0.36	Gm20281	predicted gene, 20281	58756	0.14
chr2_59979903_59980091	0.35	Gm13574	predicted gene 13574	12347	0.19
chr5_135879620_135879793	0.35	Gm22450	predicted gene, 22450	4049	0.12
chr18_20980054_20980205	0.35	Rnf125	ring finger protein 125	18657	0.18
chr17_31640162_31640374	0.35	Cbs	cystathionine beta-synthase	3030	0.13
chr11_52220968_52221143	0.35	Olfr1371	olfactory receptor 1371	7068	0.12
chr12_85112663_85112863	0.35	Dlst	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	1870	0.19
chr4_40849235_40849401	0.34	Mir5123	microRNA 5123	820	0.3
chr8_119887445_119887613	0.34	Usp10	ubiquitin specific peptidase 10	22831	0.13
chr17_29061153_29061388	0.34	Gm41556	predicted gene, 41556	3041	0.12
chr18_20989752_20989946	0.34	Rnf138	ring finger protein 138	11492	0.2
chr3_86018925_86019076	0.34	Prss48	protease, serine 48	16509	0.12
chrX_77607586_77607742	0.34	Gm23121	predicted gene, 23121	28177	0.18
chr9_48650755_48650912	0.34	Nnmt	nicotinamide N-methyltransferase	45680	0.16
chr10_77587179_77587612	0.33	Pttg1ip	pituitary tumor-transforming 1 interacting protein	1999	0.18
chr6_113011965_113012136	0.33	Gm8083	predicted gene 8083	19928	0.09
chr2_125617422_125617574	0.33	Cep152	centrosomal protein 152	7615	0.22
chr4_132476053_132476227	0.33	Med18	mediator complex subunit 18	12219	0.1
chr4_46527475_46527653	0.33	Trim14	tripartite motif-containing 14	6850	0.14
chr18_65058969_65059130	0.33	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	8059	0.24
chr9_110703228_110703412	0.33	Ccdc12	coiled-coil domain containing 12	6574	0.12
chr1_51996762_51997232	0.33	Stat4	signal transducer and activator of transcription 4	9849	0.17
chr7_44898673_44898846	0.33	Fuz	fuzzy planar cell polarity protein	492	0.42
chr1_180179778_180180226	0.33	Coq8a	coenzyme Q8A	1080	0.44
chr4_132960785_132960960	0.33	Fgr	FGR proto-oncogene, Src family tyrosine kinase	13223	0.14
chrX_169904110_169904261	0.33	Mid1	midline 1	22766	0.2
chrX_12377036_12377378	0.32	Gm14635	predicted gene 14635	22211	0.24
chr8_75092030_75092181	0.32	Hmox1	heme oxygenase 1	1516	0.3
chr14_68809096_68809247	0.32	Gm47256	predicted gene, 47256	65664	0.11
chr5_151103422_151103608	0.32	Stard13	StAR-related lipid transfer (START) domain containing 13	5220	0.28
chr9_115425112_115425263	0.32	Gm5921	predicted gene 5921	13394	0.13
chr8_126823704_126823868	0.32	A630001O12Rik	RIKEN cDNA A630001O12 gene	15447	0.2
chr6_115838733_115838884	0.32	Efcab12	EF-hand calcium binding domain 12	396	0.72
chr5_140167245_140167441	0.32	Mad1l1	MAD1 mitotic arrest deficient 1-like 1	7316	0.17
chr2_156433040_156433199	0.32	Epb41l1	erythrocyte membrane protein band 4.1 like 1	12007	0.09
chr17_70753482_70753646	0.32	5031415H12Rik	RIKEN cDNA 5031415H12 gene	2018	0.31
chr19_29520832_29521011	0.32	A930007I19Rik	RIKEN cDNA A930007I19 gene	49	0.96
chr1_190117320_190117686	0.32	Gm28172	predicted gene 28172	51167	0.13
chr16_93918744_93918905	0.32	Cldn14	claudin 14	10743	0.14
chr1_91822004_91822314	0.31	Gm29101	predicted gene 29101	356	0.87
chr6_72212494_72212706	0.31	Atoh8	atonal bHLH transcription factor 8	21937	0.14
chr16_13257357_13257584	0.31	Mrtfb	myocardin related transcription factor B	964	0.67
chr12_8829085_8829244	0.31	9930038B18Rik	RIKEN cDNA 9930038B18 gene	48218	0.11
chr5_120484543_120484824	0.31	Gm15690	predicted gene 15690	3780	0.13
chr3_131473184_131473335	0.31	Sgms2	sphingomyelin synthase 2	17220	0.23
chr2_34828383_34828580	0.31	Fbxw2	F-box and WD-40 domain protein 2	2170	0.17
chr5_66232678_66232831	0.31	Gm3822	predicted gene 3822	18007	0.11
chr12_69366525_69366676	0.31	Gm18113	predicted gene, 18113	3423	0.12
chr8_83964735_83964914	0.30	Asf1b	anti-silencing function 1B histone chaperone	223	0.83
chr3_36480639_36480833	0.30	1810062G17Rik	RIKEN cDNA 1810062G17 gene	4799	0.13
chr19_20605270_20605421	0.30	Aldh1a1	aldehyde dehydrogenase family 1, subfamily A1	3384	0.27
chr12_114378675_114378838	0.30	Ighv1-1	immunoglobulin heavy variable V1-1	26761	0.1
chr3_63315218_63315408	0.30	Mme	membrane metallo endopeptidase	15153	0.26
chr6_124905504_124905662	0.30	Lag3	lymphocyte-activation gene 3	4468	0.09
chr19_38370339_38370560	0.30	Gm50155	predicted gene, 50155	15065	0.13
chr16_91931256_91931425	0.30	Atp5o	ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit	66	0.54
chr16_10524923_10525085	0.30	Dexi	dexamethasone-induced transcript	6805	0.18
chr11_95744707_95744876	0.29	Zfp652	zinc finger protein 652	4209	0.15
chr2_77508328_77508502	0.29	Zfp385b	zinc finger protein 385B	11120	0.25
chr8_3390517_3390679	0.29	Arhgef18	rho/rac guanine nucleotide exchange factor (GEF) 18	2408	0.27
chr11_100771131_100771291	0.29	Ghdc	GH3 domain containing	254	0.85
chr7_51899481_51899655	0.29	Gas2	growth arrest specific 2	11650	0.17
chr5_104374044_104374195	0.29	Mepe	matrix extracellular phosphoglycoprotein with ASARM motif (bone)	48790	0.1
chr14_68304879_68305239	0.29	Gm47212	predicted gene, 47212	86806	0.08
chr7_30421568_30421733	0.29	Nfkbid	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, delta	82	0.91
chr13_37824271_37824422	0.29	Rreb1	ras responsive element binding protein 1	1629	0.37
chr4_107920456_107920610	0.29	Cpt2	carnitine palmitoyltransferase 2	2914	0.18
chr4_103115043_103115199	0.29	Mier1	MEIR1 treanscription regulator	151	0.84
chr6_93770976_93771287	0.29	Magi1	membrane associated guanylate kinase, WW and PDZ domain containing 1	21408	0.21
chr7_143296870_143297021	0.28	Kcnq1ot1	KCNQ1 overlapping transcript 1	396	0.65
chr15_102177432_102177780	0.28	Csad	cysteine sulfinic acid decarboxylase	1413	0.26
chr13_37953178_37953339	0.28	Rreb1	ras responsive element binding protein 1	6242	0.21
chr7_25448767_25449204	0.28	Gm15495	predicted gene 15495	5522	0.11
chr4_96583762_96583984	0.28	Cyp2j9	cytochrome P450, family 2, subfamily j, polypeptide 9	7705	0.22
chrX_10556988_10557139	0.28	Gm25885	predicted gene, 25885	47015	0.14
chr9_70069929_70070289	0.28	Gm47233	predicted gene, 47233	242	0.89
chr19_44128120_44128295	0.28	Cwf19l1	CWF19-like 1, cell cycle control (S. pombe)	5291	0.13
chr9_61911528_61911679	0.28	Rplp1	ribosomal protein, large, P1	2939	0.26
chr12_110021918_110022099	0.28	Gm34667	predicted gene, 34667	1865	0.26
chr6_30564201_30564366	0.28	Cpa4	carboxypeptidase A4	4086	0.15
chr18_46649890_46650075	0.28	Gm3734	predicted gene 3734	19175	0.14
chr4_136173095_136173459	0.28	E2f2	E2F transcription factor 2	883	0.51
chr18_61424158_61424549	0.28	Gm8755	predicted gene 8755	9848	0.12
chr4_63558749_63559072	0.28	Tmem268	transmembrane protein 268	54	0.96
chr12_35044157_35044343	0.28	Snx13	sorting nexin 13	2936	0.27
chr1_133113123_133113283	0.28	Ppp1r15b	protein phosphatase 1, regulatory subunit 15B	17940	0.13
chr3_88833523_88833680	0.28	1500004A13Rik	RIKEN cDNA 1500004A13 gene	1054	0.32
chr9_80629501_80629676	0.27	Gm48387	predicted gene, 48387	28491	0.22
chr8_70170192_70170368	0.27	Tmem161a	transmembrane protein 161A	2076	0.16
chr5_66079062_66079213	0.27	Rbm47	RNA binding motif protein 47	1847	0.24
chr11_55062992_55063153	0.27	Ccdc69	coiled-coil domain containing 69	15035	0.13
chr6_128523521_128524414	0.27	Pzp	PZP, alpha-2-macroglobulin like	2736	0.13
chr10_21686247_21686409	0.27	Gm5420	predicted gene 5420	83	0.98
chr17_25727890_25728059	0.27	Rpusd1	RNA pseudouridylate synthase domain containing 1	242	0.65
chr11_88718878_88719286	0.27	C030037D09Rik	RIKEN cDNA C030037D09 gene	278	0.72
chr5_135167079_135167237	0.27	Bcl7b	B cell CLL/lymphoma 7B	1125	0.34
chr3_103025386_103025549	0.27	Csde1	cold shock domain containing E1, RNA binding	3535	0.16
chr17_57058382_57058541	0.27	Crb3	crumbs family member 3	644	0.4
chr15_27822193_27822368	0.27	Trio	triple functional domain (PTPRF interacting)	1503	0.44
chr15_103085855_103086027	0.27	Gm28876	predicted gene 28876	16170	0.09
chr19_20450928_20451527	0.27	C730002L08Rik	RIKEN cDNA C730002L08 gene	26445	0.16
chr6_50773105_50773295	0.27	C530044C16Rik	RIKEN cDNA C530044C16 gene	2915	0.22
chr16_46098109_46098276	0.27	Gm50487	predicted gene, 50487	11717	0.18
chr12_17445944_17446108	0.27	Gm36752	predicted gene, 36752	9408	0.2
chr18_20938674_20939098	0.27	Rnf125	ring finger protein 125	5739	0.23
chr1_177664080_177664231	0.27	2310043L19Rik	RIKEN cDNA 2310043L19 gene	21212	0.16
chr5_151246921_151247115	0.26	5430435K18Rik	RIKEN cDNA 5430435K18 gene	5287	0.21
chr19_3358921_3359072	0.26	Cpt1a	carnitine palmitoyltransferase 1a, liver	7334	0.14
chr8_124923216_124923378	0.26	Sprtn	SprT-like N-terminal domain	21482	0.11
chr4_141115485_141115659	0.26	4921514A10Rik	RIKEN cDNA 4921514A10 gene	88	0.95
chr6_6997102_6997263	0.26	Sdhaf3	succinate dehydrogenase complex assembly factor 3	41175	0.13
chr2_144014015_144014533	0.26	Rrbp1	ribosome binding protein 1	3011	0.24
chr8_126919454_126919605	0.26	Gm31718	predicted gene, 31718	11314	0.16
chr2_109694324_109694484	0.26	Bdnf	brain derived neurotrophic factor	5	0.98
chr7_70800023_70800227	0.26	Gm24880	predicted gene, 24880	47709	0.15
chr4_44990961_44991112	0.26	Grhpr	glyoxylate reductase/hydroxypyruvate reductase	9536	0.11
chr14_66004934_66005102	0.26	Gulo	gulonolactone (L-) oxidase	4189	0.18
chr17_79919609_79919795	0.26	Gm6552	predicted gene 6552	14870	0.16
chr14_64445994_64446184	0.26	Msra	methionine sulfoxide reductase A	5172	0.28
chr11_97361922_97362073	0.26	Socs7	suppressor of cytokine signaling 7	438	0.76
chr5_150603699_150604014	0.26	Gm43597	predicted gene 43597	3027	0.12
chr17_87102953_87103253	0.26	Socs5	suppressor of cytokine signaling 5	4576	0.18

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr5a2

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View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	0.5	GO:0046439	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.1	0.6	GO:0006114	glycerol biosynthetic process(GO:0006114)
0.1	0.3	GO:0010046	response to mycotoxin(GO:0010046)
0.1	0.3	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.1	0.3	GO:0007412	axon target recognition(GO:0007412)
0.1	0.2	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.1	0.2	GO:0098535	de novo centriole assembly(GO:0098535)
0.1	0.2	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.1	0.2	GO:0046271	phenylpropanoid catabolic process(GO:0046271)
0.0	0.2	GO:2000561	regulation of CD4-positive, alpha-beta T cell proliferation(GO:2000561)
0.0	0.2	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.0	0.1	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.1	GO:2000313	fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.0	0.3	GO:0070245	positive regulation of thymocyte apoptotic process(GO:0070245)
0.0	0.1	GO:0006543	glutamine catabolic process(GO:0006543)
0.0	0.2	GO:1903689	regulation of wound healing, spreading of epidermal cells(GO:1903689)
0.0	0.2	GO:0097461	ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461)
0.0	0.2	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0071492	cellular response to UV-A(GO:0071492)
0.0	0.1	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.0	0.2	GO:1990086	lens fiber cell apoptotic process(GO:1990086)
0.0	0.2	GO:0090074	negative regulation of protein homodimerization activity(GO:0090074)
0.0	0.1	GO:0033668	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.0	0.2	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.0	0.3	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.1	GO:0015842	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.1	GO:0034756	regulation of iron ion transport(GO:0034756)
0.0	0.1	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.1	GO:0032789	saturated monocarboxylic acid metabolic process(GO:0032788) unsaturated monocarboxylic acid metabolic process(GO:0032789)
0.0	0.1	GO:0015770	disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
0.0	0.1	GO:0006553	lysine metabolic process(GO:0006553)
0.0	0.1	GO:0072718	response to cisplatin(GO:0072718)
0.0	0.2	GO:0071649	regulation of chemokine (C-C motif) ligand 5 production(GO:0071649)
0.0	0.2	GO:0042518	negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518)
0.0	0.3	GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis(GO:0090051)
0.0	0.1	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.1	GO:2000823	regulation of androgen receptor activity(GO:2000823)
0.0	0.3	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.2	GO:0031937	positive regulation of chromatin silencing(GO:0031937)
0.0	0.1	GO:0007039	protein catabolic process in the vacuole(GO:0007039)
0.0	0.1	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.2	GO:0031119	tRNA pseudouridine synthesis(GO:0031119)
0.0	0.1	GO:2000304	positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
0.0	0.1	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.2	GO:0045198	establishment of epithelial cell apical/basal polarity(GO:0045198)
0.0	0.1	GO:0006546	glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.0	0.1	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.1	GO:0043578	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.2	GO:0021942	radial glia guided migration of Purkinje cell(GO:0021942)
0.0	0.0	GO:0003213	cardiac right atrium morphogenesis(GO:0003213)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0031296	B cell costimulation(GO:0031296)
0.0	0.1	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.0	0.1	GO:0006597	spermine biosynthetic process(GO:0006597)
0.0	0.4	GO:0014733	regulation of skeletal muscle adaptation(GO:0014733)
0.0	0.0	GO:1902988	neurofibrillary tangle assembly(GO:1902988) regulation of neurofibrillary tangle assembly(GO:1902996)
0.0	0.6	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.1	GO:0072675	osteoclast fusion(GO:0072675)
0.0	0.1	GO:0002071	glandular epithelial cell maturation(GO:0002071)
0.0	0.1	GO:1903288	regulation of potassium ion import(GO:1903286) positive regulation of potassium ion import(GO:1903288)
0.0	0.1	GO:0072310	glomerular visceral epithelial cell development(GO:0072015) glomerular epithelial cell development(GO:0072310)
0.0	0.1	GO:0015760	hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.1	GO:1902474	positive regulation of protein localization to synapse(GO:1902474)
0.0	0.1	GO:0018094	protein polyglycylation(GO:0018094)
0.0	0.0	GO:1900186	negative regulation of clathrin-mediated endocytosis(GO:1900186)
0.0	0.1	GO:0006555	methionine metabolic process(GO:0006555)
0.0	0.1	GO:0060591	chondroblast differentiation(GO:0060591)
0.0	0.0	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.0	GO:0071677	positive regulation of mononuclear cell migration(GO:0071677)
0.0	0.2	GO:0015865	purine nucleotide transport(GO:0015865)
0.0	0.1	GO:0006624	vacuolar protein processing(GO:0006624)
0.0	0.1	GO:0098904	regulation of AV node cell action potential(GO:0098904)
0.0	0.1	GO:0071233	response to leucine(GO:0043201) cellular response to leucine(GO:0071233)
0.0	0.1	GO:0060339	negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.0	0.1	GO:0042908	xenobiotic transport(GO:0042908)
0.0	0.0	GO:0071394	cellular response to testosterone stimulus(GO:0071394)
0.0	0.1	GO:0071267	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.0	0.1	GO:0051189	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0006598	polyamine catabolic process(GO:0006598)
0.0	0.1	GO:0050904	diapedesis(GO:0050904)
0.0	0.1	GO:0052173	response to defenses of other organism involved in symbiotic interaction(GO:0052173) response to host defenses(GO:0052200) response to host(GO:0075136)
0.0	0.1	GO:0097212	lysosomal membrane organization(GO:0097212)
0.0	0.1	GO:0061073	ciliary body morphogenesis(GO:0061073)
0.0	0.1	GO:0006663	platelet activating factor biosynthetic process(GO:0006663) platelet activating factor metabolic process(GO:0046469)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.0	GO:0031284	positive regulation of guanylate cyclase activity(GO:0031284)
0.0	0.0	GO:2001197	regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
0.0	0.1	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.0	GO:1901668	regulation of superoxide dismutase activity(GO:1901668)
0.0	0.1	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:0009071	serine family amino acid catabolic process(GO:0009071)
0.0	0.1	GO:0009629	response to gravity(GO:0009629)
0.0	0.1	GO:1901475	pyruvate transmembrane transport(GO:1901475)
0.0	0.0	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.0	0.1	GO:0035927	RNA import into mitochondrion(GO:0035927)
0.0	0.1	GO:0042536	negative regulation of tumor necrosis factor biosynthetic process(GO:0042536)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.0	GO:0032348	negative regulation of aldosterone metabolic process(GO:0032345) negative regulation of aldosterone biosynthetic process(GO:0032348) negative regulation of cortisol biosynthetic process(GO:2000065)
0.0	0.1	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0	0.1	GO:0045647	negative regulation of erythrocyte differentiation(GO:0045647)
0.0	0.1	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.1	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.0	GO:2000409	positive regulation of T cell extravasation(GO:2000409)
0.0	0.1	GO:0010815	bradykinin catabolic process(GO:0010815)
0.0	0.1	GO:0033572	transferrin transport(GO:0033572)
0.0	0.1	GO:0051410	detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0	0.1	GO:0070948	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.1	GO:0048133	germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
0.0	0.0	GO:1902965	regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.0	0.1	GO:0051725	protein de-ADP-ribosylation(GO:0051725)
0.0	0.1	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
0.0	0.0	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.2	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.0	GO:1900126	negative regulation of hyaluronan biosynthetic process(GO:1900126)
0.0	0.1	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.0	GO:0060557	positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
0.0	0.2	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.0	GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998)
0.0	0.1	GO:1903553	positive regulation of extracellular exosome assembly(GO:1903553)
0.0	0.0	GO:1901674	histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.0	0.0	GO:1901525	negative regulation of macromitophagy(GO:1901525)
0.0	0.0	GO:1903377	negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.0	0.0	GO:0061623	galactose catabolic process via UDP-galactose(GO:0033499) glycolytic process from galactose(GO:0061623)
0.0	0.1	GO:0045019	negative regulation of nitric oxide biosynthetic process(GO:0045019) negative regulation of nitric oxide metabolic process(GO:1904406)
0.0	0.0	GO:0051344	negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
0.0	0.1	GO:2001286	regulation of caveolin-mediated endocytosis(GO:2001286)
0.0	0.0	GO:0072361	regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361)
0.0	0.0	GO:0018916	nitrobenzene metabolic process(GO:0018916)
0.0	0.0	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.0	0.1	GO:0035507	regulation of myosin-light-chain-phosphatase activity(GO:0035507)
0.0	0.0	GO:0019853	L-ascorbic acid biosynthetic process(GO:0019853)
0.0	0.1	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.2	GO:0045056	transcytosis(GO:0045056)
0.0	0.0	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0010992	ubiquitin homeostasis(GO:0010992)
0.0	0.0	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.0	GO:0072553	terminal button organization(GO:0072553)
0.0	0.1	GO:0010748	negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
0.0	0.1	GO:0010499	proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0	0.1	GO:1900029	positive regulation of ruffle assembly(GO:1900029)
0.0	0.0	GO:1901660	calcium ion export(GO:1901660)
0.0	0.1	GO:0045627	positive regulation of T-helper 1 cell differentiation(GO:0045627)
0.0	0.0	GO:0003104	positive regulation of glomerular filtration(GO:0003104)
0.0	0.1	GO:0072383	plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.0	0.1	GO:0032827	natural killer cell differentiation involved in immune response(GO:0002325) negative regulation of natural killer cell differentiation(GO:0032824) regulation of natural killer cell differentiation involved in immune response(GO:0032826) negative regulation of natural killer cell differentiation involved in immune response(GO:0032827)
0.0	0.0	GO:0006363	termination of RNA polymerase I transcription(GO:0006363)
0.0	0.0	GO:0002432	granuloma formation(GO:0002432)
0.0	0.1	GO:0033152	immunoglobulin V(D)J recombination(GO:0033152)
0.0	0.1	GO:0042178	xenobiotic catabolic process(GO:0042178)
0.0	0.0	GO:0002370	natural killer cell cytokine production(GO:0002370) regulation of natural killer cell cytokine production(GO:0002727)
0.0	0.1	GO:0060633	negative regulation of transcription initiation from RNA polymerase II promoter(GO:0060633) negative regulation of DNA-templated transcription, initiation(GO:2000143)
0.0	0.1	GO:0009597	detection of virus(GO:0009597)
0.0	0.0	GO:0008611	ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) cellular lipid biosynthetic process(GO:0097384) ether biosynthetic process(GO:1901503)
0.0	0.0	GO:0035582	sequestering of BMP in extracellular matrix(GO:0035582)
0.0	0.0	GO:0009449	gamma-aminobutyric acid biosynthetic process(GO:0009449)
0.0	0.2	GO:0009143	nucleoside triphosphate catabolic process(GO:0009143)
0.0	0.1	GO:0032792	negative regulation of CREB transcription factor activity(GO:0032792)
0.0	0.1	GO:0070236	negative regulation of activation-induced cell death of T cells(GO:0070236)
0.0	0.1	GO:0003376	sphingosine-1-phosphate signaling pathway(GO:0003376)
0.0	0.0	GO:0042117	monocyte activation(GO:0042117)
0.0	0.1	GO:0015825	L-serine transport(GO:0015825)
0.0	0.1	GO:0071830	chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.1	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030949)
0.0	0.1	GO:0036315	cellular response to sterol(GO:0036315)
0.0	0.1	GO:0018406	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.0	GO:0045297	mating plug formation(GO:0042628) single-organism reproductive behavior(GO:0044704) post-mating behavior(GO:0045297)
0.0	0.0	GO:0051388	positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
0.0	0.0	GO:0010796	regulation of multivesicular body size(GO:0010796)
0.0	0.0	GO:0006741	NADP biosynthetic process(GO:0006741)
0.0	0.1	GO:0035331	negative regulation of hippo signaling(GO:0035331)
0.0	0.0	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.1	GO:0070234	positive regulation of T cell apoptotic process(GO:0070234)
0.0	0.0	GO:0009448	gamma-aminobutyric acid metabolic process(GO:0009448)
0.0	0.0	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.0	GO:0071205	protein localization to juxtaparanode region of axon(GO:0071205)
0.0	0.2	GO:0006349	regulation of gene expression by genetic imprinting(GO:0006349)
0.0	0.0	GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.0	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:0006102	isocitrate metabolic process(GO:0006102)
0.0	0.0	GO:0051794	regulation of catagen(GO:0051794) positive regulation of catagen(GO:0051795)
0.0	0.1	GO:0046133	pyrimidine ribonucleoside catabolic process(GO:0046133)
0.0	0.0	GO:0006015	5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.0	0.0	GO:0003032	detection of oxygen(GO:0003032)
0.0	0.0	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.0	GO:2000275	regulation of oxidative phosphorylation uncoupler activity(GO:2000275)
0.0	0.2	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.0	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.0	GO:0051799	negative regulation of hair follicle development(GO:0051799)
0.0	0.0	GO:0006177	GMP biosynthetic process(GO:0006177)
0.0	0.1	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.0	0.1	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.0	GO:0036481	intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:0036481)
0.0	0.0	GO:0019243	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0	0.2	GO:0015985	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.0	0.1	GO:0015858	nucleoside transport(GO:0015858)
0.0	0.1	GO:0034625	fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.0	0.1	GO:0042535	positive regulation of tumor necrosis factor biosynthetic process(GO:0042535)
0.0	0.1	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.0	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.0	GO:0060480	lung goblet cell differentiation(GO:0060480)
0.0	0.0	GO:2000019	negative regulation of male gonad development(GO:2000019)
0.0	0.1	GO:0046185	aldehyde catabolic process(GO:0046185)
0.0	0.0	GO:0031282	regulation of guanylate cyclase activity(GO:0031282)
0.0	0.0	GO:0060137	maternal process involved in parturition(GO:0060137)
0.0	0.0	GO:0030382	sperm mitochondrion organization(GO:0030382)
0.0	0.0	GO:0030240	skeletal muscle thin filament assembly(GO:0030240)
0.0	0.1	GO:0097264	self proteolysis(GO:0097264)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.1	GO:1901621	negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.0	0.0	GO:0090135	actin filament branching(GO:0090135)
0.0	0.0	GO:0046122	dGTP metabolic process(GO:0046070) purine deoxyribonucleoside metabolic process(GO:0046122)
0.0	0.0	GO:0045341	MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) positive regulation of MHC class I biosynthetic process(GO:0045345)
0.0	0.0	GO:0070671	response to interleukin-12(GO:0070671)
0.0	0.1	GO:0015824	proline transport(GO:0015824)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0098536	deuterosome(GO:0098536)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.2	GO:0000276	mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.0	0.1	GO:0030891	VCB complex(GO:0030891)
0.0	0.1	GO:0097057	TRAF2-GSTP1 complex(GO:0097057)
0.0	0.1	GO:0097136	Bcl-2 family protein complex(GO:0097136)
0.0	0.3	GO:0070852	cell body fiber(GO:0070852)
0.0	0.3	GO:0030061	mitochondrial crista(GO:0030061)
0.0	0.2	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	0.1	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.1	GO:0031467	Cul7-RING ubiquitin ligase complex(GO:0031467)
0.0	0.1	GO:0036454	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0016461	unconventional myosin complex(GO:0016461)
0.0	0.3	GO:0031143	pseudopodium(GO:0031143)
0.0	0.2	GO:0000137	Golgi cis cisterna(GO:0000137)
0.0	0.1	GO:0005642	annulate lamellae(GO:0005642)
0.0	0.1	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.1	GO:0045251	mitochondrial electron transfer flavoprotein complex(GO:0017133) electron transfer flavoprotein complex(GO:0045251)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.1	GO:1990357	terminal web(GO:1990357)
0.0	0.1	GO:0034274	Atg12-Atg5-Atg16 complex(GO:0034274)
0.0	0.1	GO:0033185	dolichol-phosphate-mannose synthase complex(GO:0033185)
0.0	0.1	GO:0009331	glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0	0.0	GO:0097454	Schwann cell microvillus(GO:0097454)
0.0	0.2	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.0	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0	0.2	GO:0043240	Fanconi anaemia nuclear complex(GO:0043240)
0.0	0.1	GO:0031314	extrinsic component of mitochondrial inner membrane(GO:0031314)
0.0	0.0	GO:0071664	catenin-TCF7L2 complex(GO:0071664)
0.0	0.0	GO:0002193	MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
0.0	0.1	GO:0009279	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.0	GO:0097418	neurofibrillary tangle(GO:0097418)
0.0	0.2	GO:0031430	M band(GO:0031430)
0.0	0.1	GO:0002189	ribose phosphate diphosphokinase complex(GO:0002189)
0.0	0.1	GO:0033093	Weibel-Palade body(GO:0033093)
0.0	0.0	GO:0033186	CAF-1 complex(GO:0033186)
0.0	0.1	GO:0000815	ESCRT III complex(GO:0000815)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.3	GO:0045334	clathrin-coated endocytic vesicle(GO:0045334)
0.0	0.2	GO:0032588	trans-Golgi network membrane(GO:0032588)
0.0	0.1	GO:0044233	ER-mitochondrion membrane contact site(GO:0044233)
0.0	0.0	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
0.0	0.1	GO:0031083	BLOC-1 complex(GO:0031083)
0.0	0.1	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.1	GO:0070937	CRD-mediated mRNA stability complex(GO:0070937)
0.0	0.1	GO:0005952	cAMP-dependent protein kinase complex(GO:0005952)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.5	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)
0.0	0.1	GO:0016589	NURF complex(GO:0016589)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.1	0.3	GO:0034186	apolipoprotein A-I binding(GO:0034186)
0.1	0.2	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.1	0.6	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	0.2	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.1	0.2	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.1	0.2	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.1	0.2	GO:0052834	inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate 3-phosphatase activity(GO:0052832) inositol monophosphate 4-phosphatase activity(GO:0052833) inositol monophosphate phosphatase activity(GO:0052834)
0.1	0.2	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0004359	glutaminase activity(GO:0004359)
0.0	0.2	GO:0015173	aromatic amino acid transmembrane transporter activity(GO:0015173)
0.0	0.1	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.2	GO:0052851	cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.0	0.2	GO:0015450	P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.0	0.1	GO:0018479	benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.0	0.1	GO:0008515	sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
0.0	0.1	GO:0015315	hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.0	0.1	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.1	GO:0004974	leukotriene receptor activity(GO:0004974)
0.0	0.2	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.4	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.2	GO:0001727	lipid kinase activity(GO:0001727)
0.0	0.1	GO:0035939	microsatellite binding(GO:0035939)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	0.1	GO:0016838	carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.8	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.2	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.3	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.0	0.2	GO:0046933	proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0	0.1	GO:0004558	alpha-1,4-glucosidase activity(GO:0004558)
0.0	0.1	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.0	0.5	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.1	GO:0004691	cAMP-dependent protein kinase activity(GO:0004691)
0.0	0.1	GO:0016971	flavin-linked sulfhydryl oxidase activity(GO:0016971)
0.0	0.1	GO:0003726	double-stranded RNA adenosine deaminase activity(GO:0003726)
0.0	0.1	GO:0004630	phospholipase D activity(GO:0004630)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0044323	retinoic acid-responsive element binding(GO:0044323)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0004591	oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0	0.1	GO:0045505	dynein intermediate chain binding(GO:0045505)
0.0	0.1	GO:0004449	isocitrate dehydrogenase (NAD+) activity(GO:0004449)
0.0	0.0	GO:0030899	calcium-dependent ATPase activity(GO:0030899)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0046790	virion binding(GO:0046790)
0.0	0.1	GO:0050833	pyruvate transmembrane transporter activity(GO:0050833)
0.0	0.1	GO:0004367	glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.0	0.1	GO:0038036	sphingosine-1-phosphate receptor activity(GO:0038036)
0.0	0.2	GO:0005337	nucleoside transmembrane transporter activity(GO:0005337)
0.0	0.1	GO:0004300	enoyl-CoA hydratase activity(GO:0004300)
0.0	0.1	GO:0030151	molybdenum ion binding(GO:0030151)
0.0	0.2	GO:0005542	folic acid binding(GO:0005542)
0.0	0.3	GO:0016290	palmitoyl-CoA hydrolase activity(GO:0016290)
0.0	0.1	GO:0046974	histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0	0.1	GO:0004767	sphingomyelin phosphodiesterase activity(GO:0004767)
0.0	0.0	GO:0019776	Atg8 ligase activity(GO:0019776)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.2	GO:0005041	low-density lipoprotein receptor activity(GO:0005041)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0016936	galactoside binding(GO:0016936)
0.0	0.1	GO:0008121	ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.0	0.1	GO:0032036	myosin heavy chain binding(GO:0032036)
0.0	0.0	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.0	0.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	0.0	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.0	GO:0031559	oxidosqualene cyclase activity(GO:0031559)
0.0	0.0	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.1	GO:0070728	leucine binding(GO:0070728)
0.0	0.1	GO:1990380	Lys48-specific deubiquitinase activity(GO:1990380)
0.0	0.1	GO:0016019	N-acetylmuramoyl-L-alanine amidase activity(GO:0008745) peptidoglycan receptor activity(GO:0016019)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.0	GO:0015319	sodium:inorganic phosphate symporter activity(GO:0015319)
0.0	0.0	GO:0008142	oxysterol binding(GO:0008142)
0.0	0.1	GO:0004749	ribose phosphate diphosphokinase activity(GO:0004749)
0.0	0.1	GO:0004582	dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.0	0.1	GO:0010853	cyclase activator activity(GO:0010853) guanylate cyclase activator activity(GO:0030250)
0.0	0.2	GO:0009982	pseudouridine synthase activity(GO:0009982)
0.0	0.1	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.0	0.0	GO:0030297	transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.0	0.0	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.0	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.0	0.0	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.0	GO:0010484	H3 histone acetyltransferase activity(GO:0010484)
0.0	0.0	GO:0019788	NEDD8 transferase activity(GO:0019788)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	0.0	GO:0008486	diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486)
0.0	0.0	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0	0.1	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.2	GO:0047419	protein-N-terminal asparagine amidohydrolase activity(GO:0008418) UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity(GO:0008759) iprodione amidohydrolase activity(GO:0018748) (3,5-dichlorophenylurea)acetate amidohydrolase activity(GO:0018749) 4'-(2-hydroxyisopropyl)phenylurea amidohydrolase activity(GO:0034571) didemethylisoproturon amidohydrolase activity(GO:0034573) N-isopropylacetanilide amidohydrolase activity(GO:0034576) N-cyclohexylformamide amidohydrolase activity(GO:0034781) isonicotinic acid hydrazide hydrolase activity(GO:0034876) cis-aconitamide amidase activity(GO:0034882) gamma-N-formylaminovinylacetate hydrolase activity(GO:0034885) N2-acetyl-L-lysine deacetylase activity(GO:0043747) O-succinylbenzoate synthase activity(GO:0043748) indoleacetamide hydrolase activity(GO:0043864) N-acetylcitrulline deacetylase activity(GO:0043909) N-acetylgalactosamine-6-phosphate deacetylase activity(GO:0047419) diacetylchitobiose deacetylase activity(GO:0052773) chitooligosaccharide deacetylase activity(GO:0052790)
0.0	0.1	GO:0004563	beta-N-acetylhexosaminidase activity(GO:0004563)
0.0	0.1	GO:0102338	fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.0	0.1	GO:0043495	protein anchor(GO:0043495)
0.0	0.1	GO:0016920	pyroglutamyl-peptidase activity(GO:0016920)
0.0	0.0	GO:0004165	dodecenoyl-CoA delta-isomerase activity(GO:0004165)
0.0	0.1	GO:0001206	transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.0	0.0	GO:0016453	acetyl-CoA C-acetyltransferase activity(GO:0003985) C-acetyltransferase activity(GO:0016453)
0.0	0.1	GO:0032052	bile acid binding(GO:0032052)
0.0	0.1	GO:0031996	thioesterase binding(GO:0031996)
0.0	0.0	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	0.6	GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0	0.0	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.1	PID NECTIN PATHWAY	Nectin adhesion pathway
0.0	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
0.2	SA G1 AND S PHASES	Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.7	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.0	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.1	PID CDC42 PATHWAY	CDC42 signaling events
0.2	ST G ALPHA S PATHWAY	G alpha s Pathway
0.4	PID PI3KCI AKT PATHWAY	Class I PI3K signaling events mediated by Akt
0.0	PID PI3K PLC TRK PATHWAY	Trk receptor signaling mediated by PI3K and PLC-gamma
0.0	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.3	PID BARD1 PATHWAY	BARD1 signaling events
0.1	PID HEDGEHOG 2PATHWAY	Signaling events mediated by the Hedgehog family
0.1	PID HIF1A PATHWAY	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.0	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.0	PID ALK2 PATHWAY	ALK2 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.8	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.4	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
0.0	1.0	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.1	REACTOME TRAF6 MEDIATED NFKB ACTIVATION	Genes involved in TRAF6 mediated NF-kB activation
0.0	0.3	REACTOME N GLYCAN ANTENNAE ELONGATION	Genes involved in N-Glycan antennae elongation
0.0	0.3	REACTOME HDL MEDIATED LIPID TRANSPORT	Genes involved in HDL-mediated lipid transport
0.0	0.2	REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX	Genes involved in CDC6 association with the ORC:origin complex
0.0	0.3	REACTOME ACTIVATION OF BH3 ONLY PROTEINS	Genes involved in Activation of BH3-only proteins
0.0	0.1	REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION	Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.0	0.2	REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE	Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.0	0.2	REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	Genes involved in FGFR4 ligand binding and activation
0.0	0.1	REACTOME SIGNALING BY SCF KIT	Genes involved in Signaling by SCF-KIT
0.0	0.2	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.0	0.0	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.1	REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA	Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.0	0.3	REACTOME FANCONI ANEMIA PATHWAY	Genes involved in Fanconi Anemia pathway
0.0	0.4	REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING	Genes involved in Transferrin endocytosis and recycling
0.0	0.1	REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI	Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.0	0.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.0	0.2	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	0.0	REACTOME MRNA CAPPING	Genes involved in mRNA Capping
0.0	0.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.0	0.3	REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING	Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0	0.1	REACTOME DCC MEDIATED ATTRACTIVE SIGNALING	Genes involved in DCC mediated attractive signaling
0.0	0.1	REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	Genes involved in NF-kB is activated and signals survival
0.0	0.1	REACTOME EICOSANOID LIGAND BINDING RECEPTORS	Genes involved in Eicosanoid ligand-binding receptors
0.0	0.1	REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL	Genes involved in AKT phosphorylates targets in the cytosol
0.0	0.1	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

Results for Nr5a2

Z-value: 1.51

Motif logo

Transcription factors associated with Nr5a2

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Nr5a2 motif across conditions

Conditions sorted by the z-value of the Nr5a2 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr5a2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: