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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Nr6a1

Z-value: 2.09

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Transcription factors associated with Nr6a1

Gene Symbol	Gene ID	Gene Info
Nr6a1 Ensembl NCBI MGI UniProt	ENSMUSG00000063972.7	nuclear receptor subfamily 6, group A, member 1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_38782536_38782710	Nr6a1	1846	0.222365	-0.89	1.9e-02	Click!
chr2_38785061_38785421	Nr6a1	130	0.935081	-0.79	6.3e-02	Click!
chr2_38926124_38926288	Nr6a1	11	0.958036	0.76	8.2e-02	Click!
chr2_38786516_38786686	Nr6a1	1490	0.273857	-0.57	2.4e-01	Click!
chr2_38925438_38925645	Nr6a1	676	0.543889	0.57	2.4e-01	Click!

Activity of the Nr6a1 motif across conditions

Conditions sorted by the z-value of the Nr6a1 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr13_93618635_93618791	2.32	Gm15622	predicted gene 15622	6669	0.17
chr1_182500736_182501185	1.74	Gm37069	predicted gene, 37069	6804	0.14
chr10_8229677_8229834	1.39	Gm30906	predicted gene, 30906	53624	0.15
chr18_20987436_20987590	1.34	Rnf138	ring finger protein 138	13828	0.19
chr2_172472866_172473017	1.19	Fam209	family with sequence similarity 209	421	0.78
chr16_32685796_32686168	1.15	Tnk2	tyrosine kinase, non-receptor, 2	5168	0.16
chr17_12411169_12411345	1.11	Plg	plasminogen	32598	0.13
chr1_72854037_72854202	1.05	Igfbp2	insulin-like growth factor binding protein 2	5420	0.23
chr17_31861640_31861807	1.02	Sik1	salt inducible kinase 1	5919	0.17
chr15_102179533_102179684	0.98	Csad	cysteine sulfinic acid decarboxylase	253	0.85
chr3_131473184_131473335	0.97	Sgms2	sphingomyelin synthase 2	17220	0.23
chr2_164054230_164054392	0.95	Pabpc1l	poly(A) binding protein, cytoplasmic 1-like	6301	0.14
chr6_97901721_97901885	0.93	Gm15531	predicted gene 15531	11264	0.23
chr10_21916464_21916630	0.93	Sgk1	serum/glucocorticoid regulated kinase 1	11923	0.19
chr4_44992225_44992598	0.91	Grhpr	glyoxylate reductase/hydroxypyruvate reductase	10911	0.1
chr2_69406819_69407032	0.87	Dhrs9	dehydrogenase/reductase (SDR family) member 9	26480	0.18
chr7_112294455_112294629	0.86	Mical2	microtubule associated monooxygenase, calponin and LIM domain containing 2	21487	0.25
chr8_84068264_84068441	0.86	C330011M18Rik	RIKEN cDNA C330011M18 gene	1065	0.23
chr6_4820679_4820851	0.85	Gm20714	predicted gene 20714	4436	0.18
chr13_60709722_60709957	0.85	Dapk1	death associated protein kinase 1	13426	0.17
chr1_40132911_40133091	0.83	Gm37347	predicted gene, 37347	44490	0.11
chr9_121913349_121913521	0.82	Cyp8b1	cytochrome P450, family 8, subfamily b, polypeptide 1	2870	0.12
chr2_173974366_173974517	0.80	Atp5k-ps2	ATP synthase, H+ transporting, mitochondrial F1F0 complex, subunit E, pseudogene 2	10250	0.2
chr13_91762116_91762414	0.78	Gm27656	predicted gene, 27656	10159	0.15
chrX_77607586_77607742	0.78	Gm23121	predicted gene, 23121	28177	0.18
chr19_47385384_47385539	0.78	Sh3pxd2a	SH3 and PX domains 2A	24898	0.18
chr13_64242805_64242976	0.77	Cdc14b	CDC14 cell division cycle 14B	5752	0.11
chr9_20741226_20741380	0.76	Olfm2	olfactomedin 2	5046	0.17
chr17_33807244_33807514	0.75	Kank3	KN motif and ankyrin repeat domains 3	3140	0.1
chr5_135167079_135167237	0.72	Bcl7b	B cell CLL/lymphoma 7B	1125	0.34
chr17_33932704_33933052	0.71	Rgl2	ral guanine nucleotide dissociation stimulator-like 2	747	0.27
chr1_51877379_51877530	0.70	Gm28323	predicted gene 28323	2154	0.26
chr17_84037207_84037358	0.70	Gm49967	predicted gene, 49967	392	0.78
chr13_13558705_13559076	0.69	Lyst	lysosomal trafficking regulator	31507	0.14
chr3_96402109_96402496	0.69	Gm26654	predicted gene, 26654	79	0.72
chr19_47276101_47276391	0.67	Mir6995	microRNA 6995	2657	0.21
chr4_98108774_98108954	0.66	Gm12691	predicted gene 12691	37735	0.2
chr9_106194059_106194232	0.65	Ppm1m	protein phosphatase 1M	2743	0.13
chr5_8990837_8991059	0.65	Crot	carnitine O-octanoyltransferase	6094	0.13
chr15_11394606_11394765	0.65	Tars	threonyl-tRNA synthetase	2415	0.37
chr15_76324787_76324950	0.64	Exosc4	exosome component 4	2529	0.09
chr14_31653594_31653749	0.64	Hacl1	2-hydroxyacyl-CoA lyase 1	12385	0.14
chr4_132974220_132974503	0.62	Fgr	FGR proto-oncogene, Src family tyrosine kinase	259	0.9
chr12_85112663_85112863	0.62	Dlst	dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)	1870	0.19
chr8_10935282_10935610	0.62	Gm45042	predicted gene 45042	5559	0.11
chr2_53000554_53000705	0.62	Fmnl2	formin-like 2	142761	0.04
chr5_120501180_120501331	0.62	Plbd2	phospholipase B domain containing 2	2346	0.17
chr6_124872495_124872656	0.61	Cd4	CD4 antigen	2086	0.13
chr6_87759992_87760347	0.61	Gm5879	predicted gene 5879	6035	0.09
chr2_44142320_44142937	0.61	Arhgap15os	Rho GTPase activating protein 15, opposite strand	77304	0.11
chr11_100771131_100771291	0.61	Ghdc	GH3 domain containing	254	0.85
chr2_104736695_104736943	0.61	Depdc7	DEP domain containing 7	6059	0.16
chr2_173633527_173633866	0.59	Ppp4r1l-ps	protein phosphatase 4, regulatory subunit 1-like, pseudogene	4146	0.21
chr13_75793210_75793372	0.58	Gm8288	predicted gene 8288	9415	0.14
chr6_124905504_124905662	0.58	Lag3	lymphocyte-activation gene 3	4468	0.09
chr1_150410095_150410265	0.58	Tpr	translocated promoter region, nuclear basket protein	1817	0.32
chr1_105822945_105823096	0.58	Tnfrsf11a	tumor necrosis factor receptor superfamily, member 11a, NFKB activator	3150	0.26
chr9_85768264_85768415	0.57	Gm22830	predicted gene, 22830	4141	0.16
chr17_31640162_31640374	0.56	Cbs	cystathionine beta-synthase	3030	0.13
chr18_65058969_65059130	0.56	Nedd4l	neural precursor cell expressed, developmentally down-regulated gene 4-like	8059	0.24
chr8_44708968_44709119	0.56	Gm26089	predicted gene, 26089	107210	0.07
chr14_73136010_73136299	0.55	Rcbtb2	regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2	2614	0.29
chr8_124343978_124344300	0.55	Gm15775	predicted gene 15775	12344	0.14
chr5_118291975_118292126	0.55	Gm25076	predicted gene, 25076	25601	0.16
chr2_155279279_155279430	0.54	Map1lc3a	microtubule-associated protein 1 light chain 3 alpha	2465	0.24
chr6_72212494_72212706	0.54	Atoh8	atonal bHLH transcription factor 8	21937	0.14
chr5_32137626_32137972	0.53	Fosl2	fos-like antigen 2	1626	0.31
chr7_63916741_63916912	0.53	E030018B13Rik	RIKEN cDNA E030018B13 gene	31	0.97
chr15_81181427_81181589	0.53	Mrtfa	myocardin related transcription factor A	9014	0.14
chr3_14769683_14769846	0.53	Car1	carbonic anhydrase 1	8695	0.19
chr11_81531658_81531818	0.53	1700071K01Rik	RIKEN cDNA 1700071K01 gene	41735	0.18
chr2_126584357_126584536	0.53	Hdc	histidine decarboxylase	13815	0.16
chr11_75318270_75318428	0.53	Gm47300	predicted gene, 47300	259	0.89
chr5_123349021_123349175	0.52	Bcl7a	B cell CLL/lymphoma 7A	4598	0.1
chr3_115822649_115822812	0.51	Dph5	diphthamide biosynthesis 5	65107	0.08
chr3_108070638_108070797	0.51	Ampd2	adenosine monophosphate deaminase 2	4753	0.09
chr8_107483340_107483510	0.51	Wwp2	WW domain containing E3 ubiquitin protein ligase 2	93	0.97
chr16_16456437_16456606	0.51	Fgd4	FYVE, RhoGEF and PH domain containing 4	47701	0.11
chr5_151103422_151103608	0.51	Stard13	StAR-related lipid transfer (START) domain containing 13	5220	0.28
chr8_126772922_126773091	0.50	Gm45805	predicted gene 45805	14672	0.23
chr9_108083457_108083608	0.49	Rnf123	ring finger protein 123	186	0.77
chr6_140748785_140748936	0.49	Rpl38-ps2	ribosomal protein L38, pseudogene 2	1688	0.38
chr13_93622998_93623302	0.49	Gm15622	predicted gene 15622	2232	0.26
chr12_113071949_113072118	0.48	Pacs2	phosphofurin acidic cluster sorting protein 2	1361	0.26
chr3_91463817_91463984	0.48	S100a7l2	S100 calcium binding protein A7 like 2	373097	0.01
chr19_16479183_16479334	0.47	Gm8222	predicted gene 8222	11806	0.19
chr14_70530138_70530323	0.47	Lgi3	leucine-rich repeat LGI family, member 3	455	0.68
chr16_91796689_91796840	0.47	Itsn1	intersectin 1 (SH3 domain protein 1A)	7858	0.19
chr9_36794772_36794937	0.47	Ei24	etoposide induced 2.4 mRNA	2166	0.21
chr7_83653626_83653804	0.47	Il16	interleukin 16	1610	0.26
chr13_52972166_52972331	0.46	n-R5s54	nuclear encoded rRNA 5S 54	7516	0.18
chr2_163527264_163527415	0.46	Gm25881	predicted gene, 25881	12823	0.11
chr4_105459110_105459278	0.46	Gm12723	predicted gene 12723	52038	0.16
chr17_12392360_12392620	0.45	Plg	plasminogen	13831	0.16
chr6_119487150_119487370	0.45	Fbxl14	F-box and leucine-rich repeat protein 14	7592	0.21
chr18_46669373_46669564	0.44	Gm3734	predicted gene 3734	38661	0.1
chr16_94693543_94693992	0.44	Gm41504	predicted gene, 41504	20136	0.16
chr13_93636362_93636873	0.44	Bhmt	betaine-homocysteine methyltransferase	949	0.5
chr7_84195894_84196083	0.44	Gm44826	predicted gene 44826	14526	0.14
chr8_122274769_122274938	0.43	Zfp469	zinc finger protein 469	5284	0.17
chr10_80101643_80101815	0.43	Sbno2	strawberry notch 2	542	0.59
chr6_99540166_99540323	0.43	Foxp1	forkhead box P1	17523	0.21
chr8_33867033_33867186	0.43	Rbpms	RNA binding protein gene with multiple splicing	13436	0.16
chr8_121568635_121568786	0.43	Fbxo31	F-box protein 31	8747	0.11
chr5_92361554_92361705	0.42	Cxcl11	chemokine (C-X-C motif) ligand 11	1648	0.21
chr15_83568563_83568727	0.42	Tspo	translocator protein	4770	0.13
chr9_57233208_57233500	0.42	Trcg1	taste receptor cell gene 1	3202	0.2
chr4_145016736_145017043	0.42	Vps13d	vacuolar protein sorting 13D	32928	0.18
chr6_128095809_128095987	0.41	Gm26338	predicted gene, 26338	872	0.54
chr12_86797888_86798054	0.41	Gm10095	predicted gene 10095	48496	0.11
chr9_115342664_115342815	0.41	Stt3b	STT3, subunit of the oligosaccharyltransferase complex, homolog B (S. cerevisiae)	32318	0.11
chr19_20450928_20451527	0.41	C730002L08Rik	RIKEN cDNA C730002L08 gene	26445	0.16
chr1_21068954_21069111	0.41	Tram2	translocating chain-associating membrane protein 2	10197	0.17
chr4_132234596_132234776	0.41	Gmeb1	glucocorticoid modulatory element binding protein 1	220	0.83
chr19_20467728_20467894	0.41	Aldh1a1	aldehyde dehydrogenase family 1, subfamily A1	24904	0.18
chr16_24084566_24084855	0.40	Gm46545	predicted gene, 46545	2020	0.29
chr8_33799864_33800058	0.40	Rbpms	RNA binding protein gene with multiple splicing	2747	0.22
chr8_24448541_24448692	0.40	Gm44620	predicted gene 44620	1519	0.33
chr1_190121129_190121551	0.40	Gm28172	predicted gene 28172	47330	0.13
chr5_137610897_137611097	0.39	Pcolce	procollagen C-endopeptidase enhancer protein	295	0.7
chr4_141115485_141115659	0.39	4921514A10Rik	RIKEN cDNA 4921514A10 gene	88	0.95
chr15_36904059_36904218	0.39	Gm10384	predicted gene 10384	24322	0.13
chr14_51905961_51906128	0.39	Ndrg2	N-myc downstream regulated gene 2	2897	0.12
chr12_69366525_69366676	0.39	Gm18113	predicted gene, 18113	3423	0.12
chr16_76299623_76299791	0.38	Nrip1	nuclear receptor interacting protein 1	23951	0.22
chr14_58032344_58032511	0.38	Gm9012	predicted gene 9012	17396	0.15
chr4_144948323_144948474	0.38	Gm38074	predicted gene, 38074	10450	0.19
chr11_98754990_98755167	0.38	Thra	thyroid hormone receptor alpha	1492	0.24
chr1_167354489_167354678	0.38	Aldh9a1	aldehyde dehydrogenase 9, subfamily A1	4271	0.14
chr17_47444308_47444531	0.38	1700001C19Rik	RIKEN cDNA 1700001C19 gene	7043	0.12
chr17_69397260_69397453	0.38	Gm49894	predicted gene, 49894	13148	0.14
chr5_91740258_91740421	0.37	Trmt112-ps1	tRNA methyltransferase 11-2, pseudogene 1	2260	0.22
chr4_155604279_155604430	0.37	Slc35e2	solute carrier family 35, member E2	2410	0.14
chr19_46134425_46134604	0.37	Elovl3	elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 3	2617	0.16
chr17_26638548_26638713	0.37	Ergic1	endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1	2607	0.19
chr3_84262685_84262871	0.37	Trim2	tripartite motif-containing 2	2966	0.34
chr13_35066144_35066299	0.37	Gm48629	predicted gene, 48629	760	0.57
chr6_54883509_54883670	0.37	Gm44185	predicted gene, 44185	18833	0.18
chr6_53154644_53154804	0.37	Gm8143	predicted gene 8143	17011	0.22
chr15_25647828_25647998	0.37	Gm48996	predicted gene, 48996	13286	0.18
chr19_3358921_3359072	0.37	Cpt1a	carnitine palmitoyltransferase 1a, liver	7334	0.14
chr14_21422894_21423226	0.36	Gm25864	predicted gene, 25864	27414	0.17
chr2_91196048_91196252	0.36	Nr1h3	nuclear receptor subfamily 1, group H, member 3	999	0.35
chr19_41381691_41381880	0.36	Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	3311	0.31
chr16_31165066_31165351	0.36	Gm18237	predicted gene, 18237	7338	0.18
chr3_121200941_121201336	0.36	Gm5710	predicted gene 5710	20041	0.13
chr8_70170192_70170368	0.36	Tmem161a	transmembrane protein 161A	2076	0.16
chr14_20166542_20166877	0.36	Kcnk5	potassium channel, subfamily K, member 5	15100	0.13
chr7_65317537_65317718	0.36	Tjp1	tight junction protein 1	15322	0.21
chr1_118967578_118967755	0.36	Mir6346	microRNA 6346	13446	0.21
chr3_86018925_86019076	0.36	Prss48	protease, serine 48	16509	0.12
chr18_20984644_20984795	0.35	Rnf138	ring finger protein 138	16622	0.19
chr4_96583762_96583984	0.35	Cyp2j9	cytochrome P450, family 2, subfamily j, polypeptide 9	7705	0.22
chr2_103594624_103594957	0.35	Abtb2	ankyrin repeat and BTB (POZ) domain containing 2	28480	0.17
chr3_27474078_27474242	0.35	Gm43344	predicted gene 43344	72481	0.1
chr7_127812426_127812775	0.35	Gm45204	predicted gene 45204	907	0.28
chr10_114798917_114799087	0.35	Trhde	TRH-degrading enzyme	2368	0.27
chr11_116126235_116126386	0.35	Trim47	tripartite motif-containing 47	900	0.38
chr13_59668840_59669190	0.35	Golm1	golgi membrane protein 1	6757	0.1
chr3_83996881_83997402	0.35	Tmem131l	transmembrane 131 like	28913	0.2
chr8_109006416_109006567	0.35	D030068K23Rik	RIKEN cDNA D030068K23 gene	68731	0.11
chr10_120977639_120977804	0.35	Lemd3	LEM domain containing 3	1611	0.28
chr4_48907830_48908179	0.35	Gm12436	predicted gene 12436	9411	0.2
chr18_68235108_68235287	0.35	Ldlrad4	low density lipoprotein receptor class A domain containing 4	7130	0.19
chr9_108087094_108087536	0.34	Apeh	acylpeptide hydrolase	847	0.31
chr1_119818436_119818638	0.34	Gm8338	predicted gene 8338	774	0.53
chr18_70573730_70573894	0.34	Mbd2	methyl-CpG binding domain protein 2	5478	0.21
chr5_102643080_102643640	0.34	Arhgap24	Rho GTPase activating protein 24	81613	0.11
chr3_88833523_88833680	0.34	1500004A13Rik	RIKEN cDNA 1500004A13 gene	1054	0.32
chr7_96960854_96961014	0.34	C230038L03Rik	RIKEN cDNA C230038L03 gene	9048	0.18
chr4_41630291_41630458	0.34	Dnaic1	dynein, axonemal, intermediate chain 1	1270	0.29
chr8_120544876_120545045	0.34	Mir7687	microRNA 7687	6264	0.11
chr19_7196833_7197251	0.33	Otub1	OTU domain, ubiquitin aldehyde binding 1	3422	0.16
chr18_75800139_75800301	0.33	1700034B16Rik	RIKEN cDNA 1700034B16 gene	19188	0.18
chr9_65243868_65244187	0.33	Cilp	cartilage intermediate layer protein, nucleotide pyrophosphohydrolase	21153	0.1
chr17_80483459_80483673	0.33	Sos1	SOS Ras/Rac guanine nucleotide exchange factor 1	3113	0.28
chr1_133012626_133012917	0.33	Mdm4	transformed mouse 3T3 cell double minute 4	6087	0.16
chr8_120492128_120492303	0.33	Gse1	genetic suppressor element 1, coiled-coil protein	3768	0.18
chr15_36903404_36903565	0.33	Gm10384	predicted gene 10384	23668	0.13
chr2_165896508_165896668	0.33	Zmynd8	zinc finger, MYND-type containing 8	362	0.81
chr19_44128120_44128295	0.32	Cwf19l1	CWF19-like 1, cell cycle control (S. pombe)	5291	0.13
chr9_22155816_22155994	0.32	Pigyl	phosphatidylinositol glycan anchor biosynthesis, class Y-like	941	0.31
chr16_26362547_26362834	0.32	Cldn1	claudin 1	1896	0.48
chr15_79741187_79741771	0.32	Sun2	Sad1 and UNC84 domain containing 2	613	0.45
chr19_23002157_23002332	0.32	Gm50136	predicted gene, 50136	59210	0.12
chr15_78531814_78531981	0.32	C1qtnf6	C1q and tumor necrosis factor related protein 6	481	0.53
chr17_28010242_28010561	0.32	Anks1	ankyrin repeat and SAM domain containing 1	3056	0.16
chr19_3328497_3328665	0.32	Cpt1a	carnitine palmitoyltransferase 1a, liver	5144	0.14
chr17_44105478_44105637	0.32	Enpp4	ectonucleotide pyrophosphatase/phosphodiesterase 4	207	0.95
chr12_71041658_71041810	0.32	Arid4a	AT rich interactive domain 4A (RBP1-like)	6607	0.17
chr11_23447377_23447534	0.32	Usp34	ubiquitin specific peptidase 34	10483	0.15
chr14_41125955_41126187	0.32	Sftpa1	surfactant associated protein A1	5711	0.13
chr17_11752805_11752972	0.31	Gm10513	predicted gene 10513	20543	0.26
chr14_47186674_47186843	0.31	Gch1	GTP cyclohydrolase 1	2655	0.15
chr6_124561569_124561840	0.31	Gm18840	predicted gene, 18840	489	0.66
chr6_119409619_119409792	0.31	Adipor2	adiponectin receptor 2	7770	0.21
chr10_87517479_87517681	0.31	Pah	phenylalanine hydroxylase	4215	0.22
chr5_102537866_102538044	0.30	1700013M08Rik	RIKEN cDNA 1700013M08 gene	54666	0.14
chr1_73992943_73993094	0.30	Tns1	tensin 1	2354	0.35
chr4_19523139_19523419	0.30	Cpne3	copine III	20399	0.22

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr6a1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.9	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.1	0.8	GO:0043102	amino acid salvage(GO:0043102) L-methionine biosynthetic process(GO:0071265) L-methionine salvage(GO:0071267)
0.1	0.3	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.1	0.3	GO:0034729	histone H3-K79 methylation(GO:0034729)
0.1	0.3	GO:0043321	regulation of natural killer cell degranulation(GO:0043321)
0.1	0.4	GO:0072675	osteoclast fusion(GO:0072675)
0.1	0.3	GO:0042628	mating plug formation(GO:0042628) post-mating behavior(GO:0045297)
0.1	0.3	GO:0010792	DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792)
0.1	0.2	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.1	0.2	GO:1902630	regulation of membrane hyperpolarization(GO:1902630)
0.1	0.2	GO:0010847	regulation of chromatin assembly(GO:0010847)
0.1	0.2	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.1	0.2	GO:0046149	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.1	0.2	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.1	0.2	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.1	0.4	GO:0009071	serine family amino acid catabolic process(GO:0009071)
0.1	0.1	GO:0002254	kinin cascade(GO:0002254)
0.1	0.3	GO:0001561	fatty acid alpha-oxidation(GO:0001561)
0.1	0.2	GO:0043402	glucocorticoid mediated signaling pathway(GO:0043402)
0.1	0.1	GO:1901187	regulation of ephrin receptor signaling pathway(GO:1901187)
0.0	0.2	GO:0006686	sphingomyelin biosynthetic process(GO:0006686)
0.0	0.1	GO:0090292	nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292)
0.0	0.2	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.1	GO:0031296	B cell costimulation(GO:0031296)
0.0	0.1	GO:0001543	ovarian follicle rupture(GO:0001543)
0.0	0.2	GO:0034627	'de novo' NAD biosynthetic process(GO:0034627)
0.0	0.1	GO:0019344	cysteine biosynthetic process(GO:0019344)
0.0	0.1	GO:0038095	Fc-epsilon receptor signaling pathway(GO:0038095)
0.0	0.2	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0060800	regulation of cell differentiation involved in embryonic placenta development(GO:0060800)
0.0	0.1	GO:0045085	negative regulation of interleukin-2 biosynthetic process(GO:0045085)
0.0	0.2	GO:0045053	protein retention in Golgi apparatus(GO:0045053)
0.0	0.1	GO:0071847	TNFSF11-mediated signaling pathway(GO:0071847)
0.0	0.6	GO:0033008	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
0.0	0.2	GO:0006361	transcription initiation from RNA polymerase I promoter(GO:0006361)
0.0	0.2	GO:0044336	canonical Wnt signaling pathway involved in negative regulation of apoptotic process(GO:0044336)
0.0	0.1	GO:0006768	biotin metabolic process(GO:0006768)
0.0	0.1	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.1	GO:2000659	regulation of interleukin-1-mediated signaling pathway(GO:2000659)
0.0	0.1	GO:0015746	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
0.0	0.2	GO:0070309	lens fiber cell morphogenesis(GO:0070309)
0.0	0.4	GO:0046130	purine nucleoside catabolic process(GO:0006152) purine ribonucleoside catabolic process(GO:0046130)
0.0	0.1	GO:0002155	regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0	0.1	GO:0035461	vitamin transmembrane transport(GO:0035461)
0.0	0.1	GO:0038128	ERBB2 signaling pathway(GO:0038128)
0.0	0.2	GO:0002606	positive regulation of dendritic cell antigen processing and presentation(GO:0002606)
0.0	0.2	GO:0043562	cellular response to nitrogen starvation(GO:0006995) cellular response to nitrogen levels(GO:0043562)
0.0	0.0	GO:0032763	regulation of mast cell cytokine production(GO:0032763)
0.0	0.2	GO:0042905	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.1	GO:0018992	germ-line sex determination(GO:0018992)
0.0	0.1	GO:0060375	regulation of mast cell differentiation(GO:0060375)
0.0	0.1	GO:2000169	regulation of peptidyl-cysteine S-nitrosylation(GO:2000169)
0.0	0.1	GO:2000667	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.1	GO:0071494	cellular response to UV-C(GO:0071494)
0.0	0.1	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
0.0	0.1	GO:0035964	COPI-coated vesicle budding(GO:0035964)
0.0	0.1	GO:0050427	3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427)
0.0	0.1	GO:0016255	attachment of GPI anchor to protein(GO:0016255)
0.0	0.1	GO:0030091	protein repair(GO:0030091)
0.0	0.1	GO:0061092	regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
0.0	0.1	GO:0030242	pexophagy(GO:0030242)
0.0	0.1	GO:0034154	toll-like receptor 7 signaling pathway(GO:0034154)
0.0	0.3	GO:0036158	outer dynein arm assembly(GO:0036158)
0.0	0.2	GO:0032792	negative regulation of CREB transcription factor activity(GO:0032792)
0.0	0.3	GO:0016540	protein autoprocessing(GO:0016540)
0.0	0.2	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.1	GO:0021775	smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
0.0	0.3	GO:0048505	regulation of timing of cell differentiation(GO:0048505)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0097460	ferrous iron import into cell(GO:0097460)
0.0	0.0	GO:0016237	lysosomal microautophagy(GO:0016237) piecemeal microautophagy of nucleus(GO:0034727) late nucleophagy(GO:0044805)
0.0	0.1	GO:0097039	protein linear polyubiquitination(GO:0097039)
0.0	0.1	GO:0033762	response to glucagon(GO:0033762)
0.0	0.0	GO:0072174	metanephric tubule formation(GO:0072174)
0.0	0.1	GO:0051791	medium-chain fatty acid metabolic process(GO:0051791)
0.0	0.1	GO:0061154	endothelial tube morphogenesis(GO:0061154)
0.0	0.0	GO:0010796	regulation of multivesicular body size(GO:0010796)
0.0	0.1	GO:0002838	negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838)
0.0	0.2	GO:0035999	tetrahydrofolate interconversion(GO:0035999)
0.0	0.1	GO:0060486	Clara cell differentiation(GO:0060486)
0.0	0.2	GO:0006527	arginine catabolic process(GO:0006527)
0.0	0.1	GO:0033211	adiponectin-activated signaling pathway(GO:0033211)
0.0	0.4	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.0	0.1	GO:2000483	negative regulation of interleukin-8 secretion(GO:2000483)
0.0	0.2	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.0	0.1	GO:0035735	intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.0	0.1	GO:0032264	IMP salvage(GO:0032264)
0.0	0.1	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.0	0.0	GO:0031943	regulation of glucocorticoid metabolic process(GO:0031943)
0.0	0.1	GO:0007161	calcium-independent cell-matrix adhesion(GO:0007161)
0.0	0.1	GO:0097368	establishment of Sertoli cell barrier(GO:0097368)
0.0	0.2	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.0	0.1	GO:0032907	transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910)
0.0	0.1	GO:1903416	response to glycoside(GO:1903416)
0.0	0.1	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
0.0	0.1	GO:0071051	polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0	0.0	GO:0009757	carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255)
0.0	0.0	GO:0031944	negative regulation of glucocorticoid metabolic process(GO:0031944) negative regulation of glucocorticoid biosynthetic process(GO:0031947)
0.0	0.1	GO:0072282	metanephric nephron tubule morphogenesis(GO:0072282)
0.0	0.1	GO:0016338	calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338)
0.0	0.1	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
0.0	0.1	GO:0070358	actin polymerization-dependent cell motility(GO:0070358)
0.0	0.1	GO:1903799	negative regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903799)
0.0	0.1	GO:1901029	negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.0	0.1	GO:2000346	negative regulation of hepatocyte proliferation(GO:2000346)
0.0	0.1	GO:0046618	drug export(GO:0046618)
0.0	0.1	GO:0042559	pteridine-containing compound biosynthetic process(GO:0042559)
0.0	0.1	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.0	0.1	GO:0006556	S-adenosylmethionine biosynthetic process(GO:0006556)
0.0	0.1	GO:0048096	chromatin-mediated maintenance of transcription(GO:0048096)
0.0	0.3	GO:0060008	Sertoli cell differentiation(GO:0060008)
0.0	0.1	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.1	GO:0034497	protein localization to pre-autophagosomal structure(GO:0034497)
0.0	0.0	GO:0002432	granuloma formation(GO:0002432)
0.0	0.0	GO:2000418	positive regulation of eosinophil migration(GO:2000418)
0.0	0.1	GO:1903147	negative regulation of mitophagy(GO:1903147)
0.0	0.1	GO:0046146	tetrahydrobiopterin metabolic process(GO:0046146)
0.0	0.1	GO:0018171	peptidyl-cysteine oxidation(GO:0018171)
0.0	0.1	GO:0030538	embryonic genitalia morphogenesis(GO:0030538)
0.0	0.2	GO:0060391	positive regulation of SMAD protein import into nucleus(GO:0060391)
0.0	0.1	GO:0019240	citrulline biosynthetic process(GO:0019240)
0.0	0.1	GO:0033572	transferrin transport(GO:0033572)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.0	GO:0090361	platelet-derived growth factor production(GO:0090360) regulation of platelet-derived growth factor production(GO:0090361)
0.0	0.1	GO:0030035	microspike assembly(GO:0030035)
0.0	0.0	GO:0007403	glial cell fate determination(GO:0007403)
0.0	0.2	GO:1900119	positive regulation of execution phase of apoptosis(GO:1900119)
0.0	0.2	GO:0097237	cellular response to toxic substance(GO:0097237)
0.0	0.0	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.1	GO:0030917	midbrain-hindbrain boundary development(GO:0030917)
0.0	0.0	GO:0006534	cysteine metabolic process(GO:0006534)
0.0	0.1	GO:0051387	negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
0.0	0.0	GO:0060125	negative regulation of growth hormone secretion(GO:0060125)
0.0	0.0	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0	0.0	GO:0007354	zygotic determination of anterior/posterior axis, embryo(GO:0007354)
0.0	0.0	GO:0036092	phosphatidylinositol-3-phosphate biosynthetic process(GO:0036092)
0.0	0.0	GO:2000152	regulation of ubiquitin-specific protease activity(GO:2000152)
0.0	0.1	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.1	GO:0002681	somatic diversification of T cell receptor genes(GO:0002568) somatic recombination of T cell receptor gene segments(GO:0002681) T cell receptor V(D)J recombination(GO:0033153)
0.0	0.0	GO:0015888	thiamine transport(GO:0015888)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.1	GO:0007288	sperm axoneme assembly(GO:0007288)
0.0	0.5	GO:1901016	regulation of potassium ion transmembrane transporter activity(GO:1901016)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.1	GO:0051152	positive regulation of smooth muscle cell differentiation(GO:0051152)
0.0	0.0	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.1	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.1	GO:0035970	peptidyl-threonine dephosphorylation(GO:0035970)
0.0	0.1	GO:0017182	peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.0	0.1	GO:0032509	endosome transport via multivesicular body sorting pathway(GO:0032509)
0.0	0.0	GO:0002378	immunoglobulin biosynthetic process(GO:0002378)
0.0	0.1	GO:1900113	negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.0	0.1	GO:1904668	positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0	0.1	GO:0048387	negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.0	0.1	GO:0006407	rRNA export from nucleus(GO:0006407)
0.0	0.1	GO:0070431	nucleotide-binding oligomerization domain containing signaling pathway(GO:0070423) nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070431)
0.0	0.1	GO:0033601	positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.0	0.0	GO:0071930	negative regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071930)
0.0	0.1	GO:0070327	thyroid hormone transport(GO:0070327)
0.0	0.0	GO:0008582	regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0	0.0	GO:0033499	galactose catabolic process via UDP-galactose(GO:0033499) glycolytic process from galactose(GO:0061623)
0.0	0.0	GO:0061113	pancreas morphogenesis(GO:0061113)
0.0	0.1	GO:0038166	angiotensin-activated signaling pathway(GO:0038166)
0.0	0.0	GO:0048319	axial mesoderm morphogenesis(GO:0048319)
0.0	0.0	GO:1902775	mitochondrial large ribosomal subunit assembly(GO:1902775)
0.0	0.0	GO:0035359	negative regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035359)
0.0	0.0	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.1	GO:0061304	retinal blood vessel morphogenesis(GO:0061304)
0.0	0.0	GO:0006166	purine ribonucleoside salvage(GO:0006166)
0.0	0.1	GO:0086036	regulation of cardiac muscle cell membrane potential(GO:0086036)
0.0	0.3	GO:0018279	protein N-linked glycosylation via asparagine(GO:0018279)
0.0	0.1	GO:2000310	regulation of N-methyl-D-aspartate selective glutamate receptor activity(GO:2000310)
0.0	0.0	GO:0018916	nitrobenzene metabolic process(GO:0018916)
0.0	0.1	GO:0042590	antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
0.0	0.1	GO:0032836	glomerular basement membrane development(GO:0032836)
0.0	0.2	GO:0071108	protein K48-linked deubiquitination(GO:0071108)
0.0	0.0	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.1	GO:2000369	regulation of clathrin-mediated endocytosis(GO:2000369)
0.0	0.0	GO:0090168	Golgi reassembly(GO:0090168)
0.0	0.0	GO:0003383	apical constriction(GO:0003383)
0.0	0.0	GO:0060316	positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0	0.1	GO:0015868	purine ribonucleotide transport(GO:0015868)
0.0	0.0	GO:0006348	chromatin silencing at telomere(GO:0006348)
0.0	0.0	GO:0010990	regulation of SMAD protein complex assembly(GO:0010990) negative regulation of SMAD protein complex assembly(GO:0010991)
0.0	0.0	GO:0016480	negative regulation of transcription from RNA polymerase III promoter(GO:0016480)
0.0	0.0	GO:0021937	cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.0	0.0	GO:0035995	detection of muscle stretch(GO:0035995)
0.0	0.2	GO:0006730	one-carbon metabolic process(GO:0006730)
0.0	0.0	GO:0001998	angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998)
0.0	0.1	GO:0003334	keratinocyte development(GO:0003334)
0.0	0.0	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0070120	ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
0.0	0.0	GO:0010958	regulation of amino acid import(GO:0010958)
0.0	0.0	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.1	GO:0071670	smooth muscle cell chemotaxis(GO:0071670)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.6	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.1	0.2	GO:0035061	interchromatin granule(GO:0035061)
0.1	0.2	GO:0030313	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.2	GO:0044615	nuclear pore nuclear basket(GO:0044615)
0.0	0.3	GO:0036157	outer dynein arm(GO:0036157)
0.0	0.2	GO:0042567	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0071797	LUBAC complex(GO:0071797)
0.0	0.3	GO:0046581	intercellular canaliculus(GO:0046581)
0.0	0.1	GO:0042765	GPI-anchor transamidase complex(GO:0042765)
0.0	0.1	GO:1990712	HFE-transferrin receptor complex(GO:1990712)
0.0	0.2	GO:0000124	SAGA complex(GO:0000124)
0.0	0.2	GO:0031143	pseudopodium(GO:0031143)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.1	GO:0045252	oxoglutarate dehydrogenase complex(GO:0045252)
0.0	0.1	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.0	0.1	GO:1990851	Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.0	0.1	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.1	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.1	GO:0034993	microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0	0.1	GO:1990454	L-type voltage-gated calcium channel complex(GO:1990454)
0.0	0.1	GO:0089701	U2AF(GO:0089701)
0.0	0.1	GO:0071141	SMAD protein complex(GO:0071141)
0.0	0.1	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.0	0.1	GO:0035189	Rb-E2F complex(GO:0035189)
0.0	0.3	GO:0097440	apical dendrite(GO:0097440)
0.0	0.3	GO:0002102	podosome(GO:0002102)
0.0	0.1	GO:0016593	Cdc73/Paf1 complex(GO:0016593)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.3	GO:0035861	site of double-strand break(GO:0035861)
0.0	0.1	GO:0000120	RNA polymerase I transcription factor complex(GO:0000120)
0.0	0.1	GO:0033256	I-kappaB/NF-kappaB complex(GO:0033256)
0.0	0.1	GO:0030008	TRAPP complex(GO:0030008)
0.0	0.0	GO:0000811	GINS complex(GO:0000811)
0.0	0.2	GO:0031528	microvillus membrane(GO:0031528)
0.0	0.0	GO:0005588	collagen type V trimer(GO:0005588)
0.0	0.0	GO:0005958	DNA-dependent protein kinase-DNA ligase 4 complex(GO:0005958)
0.0	0.0	GO:0097025	MPP7-DLG1-LIN7 complex(GO:0097025)
0.0	0.0	GO:1990761	growth cone lamellipodium(GO:1990761)
0.0	0.1	GO:0035032	phosphatidylinositol 3-kinase complex, class III(GO:0035032)
0.0	0.6	GO:0032587	ruffle membrane(GO:0032587)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	0.8	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.2	0.6	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
0.1	0.3	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.1	0.2	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.1	0.2	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.1	0.2	GO:0019959	interleukin-8 binding(GO:0019959)
0.1	0.2	GO:0072345	NAADP-sensitive calcium-release channel activity(GO:0072345)
0.1	0.6	GO:0031995	insulin-like growth factor II binding(GO:0031995)
0.1	0.2	GO:0070840	dynein complex binding(GO:0070840)
0.1	0.2	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.1	0.2	GO:0042289	MHC class II protein binding(GO:0042289)
0.0	0.2	GO:0030976	thiamine pyrophosphate binding(GO:0030976)
0.0	0.1	GO:0055100	adiponectin binding(GO:0055100)
0.0	0.3	GO:0016936	galactoside binding(GO:0016936)
0.0	0.2	GO:0047035	testosterone dehydrogenase (NAD+) activity(GO:0047035)
0.0	0.2	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.1	GO:0004724	magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0	0.1	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
0.0	0.1	GO:0034235	GPI anchor binding(GO:0034235)
0.0	0.2	GO:0016615	malate dehydrogenase activity(GO:0016615)
0.0	0.1	GO:0005176	ErbB-2 class receptor binding(GO:0005176)
0.0	0.1	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.2	GO:0034785	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.2	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.8	GO:0016831	carboxy-lyase activity(GO:0016831)
0.0	0.1	GO:0008525	phosphatidylcholine transporter activity(GO:0008525)
0.0	0.2	GO:0003836	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836)
0.0	0.1	GO:0005001	transmembrane receptor protein tyrosine phosphatase activity(GO:0005001)
0.0	0.1	GO:0019797	procollagen-proline 3-dioxygenase activity(GO:0019797)
0.0	0.2	GO:0016176	superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.0	0.1	GO:0034618	arginine binding(GO:0034618)
0.0	0.2	GO:0005381	iron ion transmembrane transporter activity(GO:0005381)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0008184	glycogen phosphorylase activity(GO:0008184)
0.0	0.2	GO:0050700	CARD domain binding(GO:0050700)
0.0	0.1	GO:0005329	dopamine transmembrane transporter activity(GO:0005329)
0.0	0.1	GO:0004886	9-cis retinoic acid receptor activity(GO:0004886)
0.0	0.2	GO:0005222	intracellular cAMP activated cation channel activity(GO:0005222)
0.0	0.1	GO:0004064	arylesterase activity(GO:0004064)
0.0	0.1	GO:0003876	AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.0	0.1	GO:0052650	NADP-retinol dehydrogenase activity(GO:0052650)
0.0	0.1	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
0.0	0.2	GO:0008140	cAMP response element binding protein binding(GO:0008140)
0.0	0.1	GO:0001875	lipopolysaccharide receptor activity(GO:0001875)
0.0	0.1	GO:0005432	calcium:sodium antiporter activity(GO:0005432)
0.0	0.1	GO:0016833	oxo-acid-lyase activity(GO:0016833)
0.0	0.1	GO:0050692	DBD domain binding(GO:0050692)
0.0	0.1	GO:0015038	glutathione disulfide oxidoreductase activity(GO:0015038)
0.0	0.2	GO:0004676	3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.0	0.3	GO:0004198	calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0	0.2	GO:0016813	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.0	0.1	GO:0004945	angiotensin type II receptor activity(GO:0004945)
0.0	0.1	GO:0004095	carnitine O-palmitoyltransferase activity(GO:0004095)
0.0	0.0	GO:0004096	catalase activity(GO:0004096)
0.0	0.0	GO:0008503	benzodiazepine receptor activity(GO:0008503)
0.0	0.1	GO:0031849	olfactory receptor binding(GO:0031849)
0.0	0.3	GO:0035259	glucocorticoid receptor binding(GO:0035259)
0.0	0.0	GO:0008309	double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.1	GO:0019834	phospholipase A2 inhibitor activity(GO:0019834)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.3	GO:0019825	oxygen binding(GO:0019825)
0.0	0.1	GO:0051864	histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0	0.0	GO:0008905	mannose-phosphate guanylyltransferase activity(GO:0008905)
0.0	0.1	GO:0008379	thioredoxin peroxidase activity(GO:0008379)
0.0	0.0	GO:0015563	uptake transmembrane transporter activity(GO:0015563)
0.0	0.0	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.0	0.5	GO:0031624	ubiquitin conjugating enzyme binding(GO:0031624)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.1	GO:0008113	peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.0	0.2	GO:0005542	folic acid binding(GO:0005542)
0.0	0.2	GO:0016780	phosphotransferase activity, for other substituted phosphate groups(GO:0016780)
0.0	0.2	GO:0034185	apolipoprotein binding(GO:0034185)
0.0	0.1	GO:0102391	decanoate--CoA ligase activity(GO:0102391)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.2	GO:0016594	glycine binding(GO:0016594)
0.0	0.0	GO:0030492	hemoglobin binding(GO:0030492)
0.0	0.1	GO:0043237	laminin-1 binding(GO:0043237)
0.0	0.1	GO:0004897	ciliary neurotrophic factor receptor activity(GO:0004897)
0.0	0.1	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.0	GO:0004859	phospholipase inhibitor activity(GO:0004859)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.0	GO:0019912	cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.0	0.1	GO:0086080	protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0	0.1	GO:0019992	diacylglycerol binding(GO:0019992)
0.0	0.2	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.1	GO:0050733	RS domain binding(GO:0050733)
0.0	0.1	GO:0008429	phosphatidylethanolamine binding(GO:0008429)
0.0	0.0	GO:0046979	TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.0	0.1	GO:0001849	complement component C1q binding(GO:0001849)
0.0	0.0	GO:0030943	mitochondrion targeting sequence binding(GO:0030943)
0.0	0.3	GO:0005104	fibroblast growth factor receptor binding(GO:0005104)
0.0	0.1	GO:0019957	C-C chemokine binding(GO:0019957)
0.0	0.3	GO:0016504	peptidase activator activity(GO:0016504)
0.0	0.0	GO:0016520	growth hormone-releasing hormone receptor activity(GO:0016520)
0.0	0.0	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.0	GO:0001030	RNA polymerase III regulatory region DNA binding(GO:0001016) RNA polymerase III type 1 promoter DNA binding(GO:0001030) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III type 3 promoter DNA binding(GO:0001032) 5S rDNA binding(GO:0080084)
0.0	0.0	GO:0097016	L27 domain binding(GO:0097016)
0.0	0.1	GO:0016884	carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0	0.1	GO:0004779	sulfate adenylyltransferase activity(GO:0004779)
0.0	0.0	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.0	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
0.0	0.1	GO:0008239	dipeptidyl-peptidase activity(GO:0008239)
0.0	0.0	GO:0061629	RNA polymerase II sequence-specific DNA binding transcription factor binding(GO:0061629)
0.0	0.2	GO:0017075	syntaxin-1 binding(GO:0017075)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.8	PID IL8 CXCR1 PATHWAY	IL8- and CXCR1-mediated signaling events
0.0	PID S1P S1P1 PATHWAY	S1P1 pathway
0.4	ST P38 MAPK PATHWAY	p38 MAPK Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.7	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.0	0.7	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.0	0.6	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
0.0	0.1	REACTOME BINDING AND ENTRY OF HIV VIRION	Genes involved in Binding and entry of HIV virion
0.0	0.1	REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION	Genes involved in RORA Activates Circadian Expression
0.0	0.3	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.0	0.5	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.0	0.2	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
0.0	0.2	REACTOME ROLE OF DCC IN REGULATING APOPTOSIS	Genes involved in Role of DCC in regulating apoptosis
0.0	0.1	REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1	Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
0.0	0.2	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
0.0	0.3	REACTOME CITRIC ACID CYCLE TCA CYCLE	Genes involved in Citric acid cycle (TCA cycle)
0.0	0.2	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis
0.0	0.1	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 7ALPHA HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
0.0	0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.0	0.1	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation
0.0	0.1	REACTOME REGULATED PROTEOLYSIS OF P75NTR	Genes involved in Regulated proteolysis of p75NTR
0.0	0.0	REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION	Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.0	0.4	REACTOME MRNA 3 END PROCESSING	Genes involved in mRNA 3'-end processing
0.0	0.2	REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.0	0.1	REACTOME G0 AND EARLY G1	Genes involved in G0 and Early G1
0.0	0.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.0	0.0	REACTOME MRNA CAPPING	Genes involved in mRNA Capping
0.0	0.2	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.0	0.0	REACTOME INFLUENZA LIFE CYCLE	Genes involved in Influenza Life Cycle
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP	Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.0	0.3	REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS	Genes involved in Sphingolipid de novo biosynthesis
0.0	0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation

Results for Nr6a1

Z-value: 2.09

Motif logo

Transcription factors associated with Nr6a1

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Nr6a1 motif across conditions

Conditions sorted by the z-value of the Nr6a1 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Nr6a1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: