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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Pax1_Pax9

Z-value: 0.92

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Transcription factors associated with Pax1_Pax9

Gene Symbol	Gene ID	Gene Info
Pax1 Ensembl NCBI MGI UniProt	ENSMUSG00000037034.9	Pax1
Pax9 Ensembl NCBI MGI UniProt	ENSMUSG00000001497.12	Pax9

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Pax1	chr2_147379046_147379216	10849	0.163052	-0.76	8.2e-02	Click!
Pax9	chr12_56695474_56695637	84	0.959601	0.72	1.0e-01	Click!
Pax9	chr12_56689847_56690002	1843	0.264032	-0.37	4.7e-01	Click!
Pax9	chr12_56681655_56681817	10031	0.138347	0.21	6.9e-01	Click!

Activity of the Pax1_Pax9 motif across conditions

Conditions sorted by the z-value of the Pax1_Pax9 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr4_138510025_138510190	1.30	Camk2n1	calcium/calmodulin-dependent protein kinase II inhibitor 1	55793	0.09
chr3_95652051_95652202	1.16	Mcl1	myeloid cell leukemia sequence 1	6662	0.1
chr10_61160789_61160964	1.01	Tbata	thymus, brain and testes associated	11078	0.15
chr11_94347313_94347820	0.89	Abcc3	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	3620	0.18
chr2_158225371_158225751	0.77	D630003M21Rik	RIKEN cDNA D630003M21 gene	3661	0.17
chr12_83375040_83375279	0.73	Dpf3	D4, zinc and double PHD fingers, family 3	24264	0.22
chr9_43744780_43745133	0.70	Nectin1	nectin cell adhesion molecule 1	312	0.63
chr6_128519043_128519655	0.67	Pzp	PZP, alpha-2-macroglobulin like	7354	0.09
chr4_150544312_150544715	0.64	Gm13091	predicted gene 13091	24031	0.18
chr5_120125413_120125579	0.62	Rbm19	RNA binding motif protein 19	6900	0.2
chr2_25431594_25431764	0.61	Abca2	ATP-binding cassette, sub-family A (ABC1), member 2	2976	0.1
chr2_90547180_90547349	0.60	Ptprj	protein tyrosine phosphatase, receptor type, J	33383	0.16
chr12_3861728_3861888	0.56	Dnmt3aos	DNA methyltransferase 3A, opposite strand	436	0.65
chr6_72637356_72637527	0.56	Gm37969	predicted gene, 37969	1114	0.24
chr2_84386945_84387393	0.55	Calcrl	calcitonin receptor-like	11811	0.2
chr9_120743578_120743729	0.55	Gm47064	predicted gene, 47064	7490	0.13
chr8_94838256_94838419	0.54	Coq9	coenzyme Q9	16	0.49
chr9_95573382_95573533	0.53	Paqr9	progestin and adipoQ receptor family member IX	13800	0.12
chr19_24159844_24160184	0.52	Gm50308	predicted gene, 50308	5944	0.18
chr10_78447521_78447672	0.51	Pdxk	pyridoxal (pyridoxine, vitamin B6) kinase	650	0.43
chr5_22345406_22345583	0.48	Reln	reelin	792	0.56
chr9_116947417_116947569	0.48	Gm18489	predicted gene, 18489	111665	0.07
chr5_62622955_62623325	0.48	Gm43237	predicted gene 43237	9682	0.2
chr2_33468229_33468380	0.47	Zbtb43	zinc finger and BTB domain containing 43	201	0.93
chr6_92316933_92317084	0.46	Gm44024	predicted gene, 44024	35615	0.15
chr4_140630998_140631188	0.46	Arhgef10l	Rho guanine nucleotide exchange factor (GEF) 10-like	14028	0.17
chr15_78796259_78796421	0.46	Card10	caspase recruitment domain family, member 10	5825	0.12
chr8_69822995_69823178	0.43	Lpar2	lysophosphatidic acid receptor 2	502	0.65
chr12_75846819_75846970	0.41	Syne2	spectrin repeat containing, nuclear envelope 2	5836	0.27
chr13_54562670_54563000	0.41	4833439L19Rik	RIKEN cDNA 4833439L19 gene	2456	0.16
chr18_34328570_34328733	0.40	Srp19	signal recognition particle 19	2196	0.29
chr17_80833916_80834067	0.40	C230072F16Rik	RIKEN cDNA C230072F16 gene	62802	0.11
chr15_73511980_73512328	0.39	Dennd3	DENN/MADD domain containing 3	406	0.84
chr11_94328339_94328510	0.38	Ankrd40	ankyrin repeat domain 40	170	0.93
chr4_60154082_60154314	0.38	Mup2	major urinary protein 2	91	0.94
chr17_87312523_87312681	0.37	Ttc7	tetratricopeptide repeat domain 7	3270	0.19
chr4_106577621_106577846	0.37	Gm12744	predicted gene 12744	11375	0.11
chr16_36711893_36712056	0.36	Ildr1	immunoglobulin-like domain containing receptor 1	3564	0.17
chr6_141610892_141611057	0.36	Slco1b2	solute carrier organic anion transporter family, member 1b2	18544	0.24
chr11_87442907_87443064	0.35	Rnu3b1	U3B small nuclear RNA 1	252	0.8
chr6_35303511_35303677	0.35	Slc13a4	solute carrier family 13 (sodium/sulfate symporters), member 4	4535	0.18
chr5_65421020_65421518	0.35	Ugdh	UDP-glucose dehydrogenase	1537	0.22
chr4_135801615_135801933	0.35	Myom3	myomesin family, member 3	1130	0.41
chr12_3858258_3858439	0.35	Dnmt3a	DNA methyltransferase 3A	2673	0.24
chr8_120538771_120538958	0.34	Mir7687	microRNA 7687	168	0.87
chr1_82281771_82282153	0.34	Irs1	insulin receptor substrate 1	9454	0.19
chr10_28081351_28081686	0.34	Ptprk	protein tyrosine phosphatase, receptor type, K	6508	0.24
chr6_90763367_90763528	0.34	Iqsec1	IQ motif and Sec7 domain 1	694	0.67
chr1_59202432_59202591	0.32	Als2	alsin Rho guanine nucleotide exchange factor	16615	0.14
chr12_17750620_17750832	0.32	Hpcal1	hippocalcin-like 1	22500	0.2
chr16_4029500_4029663	0.32	Dnase1	deoxyribonuclease I	7361	0.1
chr2_155546997_155547269	0.31	Gm20637	predicted gene 20637	748	0.41
chr3_131327635_131327824	0.31	Sgms2	sphingomyelin synthase 2	17204	0.13
chr14_121129398_121129725	0.30	Farp1	FERM, RhoGEF (Arhgef) and pleckstrin domain protein 1 (chondrocyte-derived)	27482	0.23
chr2_163345083_163345234	0.30	Tox2	TOX high mobility group box family member 2	24780	0.15
chr2_59884229_59884405	0.29	Wdsub1	WD repeat, SAM and U-box domain containing 1	1726	0.39
chr5_92369721_92369887	0.29	Cxcl11	chemokine (C-X-C motif) ligand 11	4319	0.12
chr5_66114850_66115151	0.29	Rbm47	RNA binding motif protein 47	16809	0.11
chr2_33361310_33361488	0.29	Gm25998	predicted gene, 25998	1647	0.33
chr8_121326131_121326500	0.28	Gm26815	predicted gene, 26815	30521	0.17
chr15_67062566_67062733	0.28	Gm31342	predicted gene, 31342	22591	0.2
chr9_46126472_46126634	0.28	Sik3	SIK family kinase 3	3316	0.24
chr6_119669877_119670185	0.28	Erc1	ELKS/RAB6-interacting/CAST family member 1	47926	0.16
chr3_85022833_85023030	0.28	Fbxw7	F-box and WD-40 domain protein 7	70785	0.12
chr11_87448290_87448449	0.28	Rnu3b3	U3B small nuclear RNA 3	258	0.81
chr4_35082276_35082489	0.27	Ifnk	interferon kappa	69674	0.09
chr3_118478170_118478340	0.27	Gm26871	predicted gene, 26871	20596	0.14
chr12_84161882_84162074	0.27	Elmsan1	ELM2 and Myb/SANT-like domain containing 1	1840	0.21
chr18_64661052_64661203	0.26	Atp8b1	ATPase, class I, type 8B, member 1	140	0.95
chr8_27197023_27197181	0.26	Got1l1	glutamic-oxaloacetic transaminase 1-like 1	1615	0.23
chr8_46540344_46540495	0.25	Acsl1	acyl-CoA synthetase long-chain family member 1	9355	0.15
chr4_61451087_61451318	0.25	Mup-ps12	major urinary protein, pseudogene 12	1042	0.53
chr4_55014920_55015072	0.25	Zfp462	zinc finger protein 462	3516	0.32
chr9_61370295_61371248	0.25	Gm10655	predicted gene 10655	856	0.53
chr9_66511801_66511983	0.25	Fbxl22	F-box and leucine-rich repeat protein 22	2717	0.23
chr18_53460193_53460360	0.25	Prdm6	PR domain containing 6	3307	0.33
chr10_96374728_96374886	0.25	Gm48428	predicted gene, 48428	28983	0.15
chr10_85193452_85193650	0.25	Cry1	cryptochrome 1 (photolyase-like)	8487	0.2
chr17_3121877_3122042	0.24	Gm49798	predicted gene, 49798	2842	0.14
chr5_32441483_32441679	0.24	Ppp1cb	protein phosphatase 1 catalytic subunit beta	17262	0.11
chr13_80893348_80893872	0.24	Arrdc3	arrestin domain containing 3	3092	0.22
chr2_152396769_152396934	0.24	Sox12	SRY (sex determining region Y)-box 12	1195	0.26
chr9_20862237_20862476	0.24	Shfl	shiftless antiviral inhibitor of ribosomal frameshifting	6286	0.09
chr2_152792514_152792820	0.24	Gm23802	predicted gene, 23802	19778	0.11
chr9_104140474_104140634	0.23	Dnajc13	DnaJ heat shock protein family (Hsp40) member C13	12942	0.11
chr13_42829016_42829414	0.23	Phactr1	phosphatase and actin regulator 1	37032	0.15
chr5_135674436_135674608	0.23	Por	P450 (cytochrome) oxidoreductase	59	0.94
chr5_127633759_127633922	0.23	Slc15a4	solute carrier family 15, member 4	943	0.47
chr1_180161827_180161978	0.22	Cdc42bpa	CDC42 binding protein kinase alpha	895	0.53
chr3_41101300_41101479	0.22	Pgrmc2	progesterone receptor membrane component 2	18343	0.18
chr1_64787740_64787910	0.22	Plekhm3	pleckstrin homology domain containing, family M, member 3	48939	0.1
chr13_81323663_81323834	0.22	Adgrv1	adhesion G protein-coupled receptor V1	19088	0.24
chr2_90474865_90475228	0.22	Ptprj	protein tyrosine phosphatase, receptor type, J	3710	0.21
chr18_64633009_64633171	0.22	Gm6978	predicted gene 6978	19991	0.13
chr15_74921417_74921675	0.22	Gm6610	predicted gene 6610	2898	0.13
chr5_66000185_66000354	0.21	9130230L23Rik	RIKEN cDNA 9130230L23 gene	51	0.96
chr7_44748389_44748555	0.21	Vrk3	vaccinia related kinase 3	13	0.55
chr4_130120889_130121053	0.21	Pef1	penta-EF hand domain containing 1	13415	0.14
chr7_37961383_37961554	0.21	Uri1	URI1, prefoldin-like chaperone	1060	0.6
chr1_58718073_58718224	0.20	Cflar	CASP8 and FADD-like apoptosis regulator	4262	0.15
chr4_40143379_40143566	0.20	Aco1	aconitase 1	391	0.86
chr15_10901895_10902215	0.20	Gm29742	predicted gene, 29742	15382	0.17
chr13_62884266_62884452	0.20	Fbp1	fructose bisphosphatase 1	3768	0.17
chr3_87982848_87983167	0.19	Bcan	brevican	11448	0.09
chr14_30570457_30570647	0.19	Tkt	transketolase	847	0.47
chr6_54792866_54793180	0.19	Znrf2	zinc and ring finger 2	23893	0.19
chr2_32983682_32983870	0.19	Slc2a8	solute carrier family 2, (facilitated glucose transporter), member 8	1693	0.23
chr2_103811926_103812077	0.19	Gm13878	predicted gene 13878	384	0.68
chr1_134566100_134566265	0.19	Kdm5b	lysine (K)-specific demethylase 5B	5975	0.14
chr4_60755643_60755889	0.19	Mup-ps8	major urinary protein, pseudogene 8	1046	0.52
chr12_76927037_76927196	0.19	Max	Max protein	12878	0.15
chr2_132110806_132111002	0.18	Slc23a2	solute carrier family 23 (nucleobase transporters), member 2	544	0.75
chr19_47067586_47067748	0.18	Taf5	TATA-box binding protein associated factor 5	79	0.94
chr11_113722506_113722673	0.18	Cpsf4l	cleavage and polyadenylation specific factor 4-like	12572	0.13
chr10_13553038_13553200	0.18	Pex3	peroxisomal biogenesis factor 3	1	0.75
chr13_41341555_41341714	0.18	Nedd9	neural precursor cell expressed, developmentally down-regulated gene 9	17613	0.13
chr3_122293242_122293417	0.18	Gm40190	predicted gene, 40190	110	0.55
chr13_90963501_90963652	0.18	Rps23	ribosomal protein S23	39391	0.17
chr1_21240367_21240700	0.18	Gsta3	glutathione S-transferase, alpha 3	56	0.96
chr5_146793134_146793310	0.18	Usp12	ubiquitin specific peptidase 12	1784	0.25
chr5_138857853_138858235	0.17	Gm5294	predicted gene 5294	37964	0.15
chr2_160871410_160871577	0.17	Zhx3	zinc fingers and homeoboxes 3	1079	0.41
chr5_102483708_102483875	0.17	1700013M08Rik	RIKEN cDNA 1700013M08 gene	502	0.8
chr18_20749064_20749237	0.17	B4galt6	UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 6	2746	0.29
chr9_50845710_50845905	0.17	Ppp2r1b	protein phosphatase 2, regulatory subunit A, beta	506	0.74
chr13_66986541_66986692	0.17	Ptdss1	phosphatidylserine synthase 1	6852	0.12
chr11_50022246_50022426	0.17	Rnf130	ring finger protein 130	3010	0.24
chr2_51056109_51056315	0.17	Rnd3	Rho family GTPase 3	92882	0.08
chr9_96258590_96258741	0.17	Tfdp2	transcription factor Dp 2	40	0.97
chr12_111547368_111547748	0.17	Eif5	eukaryotic translation initiation factor 5	4727	0.12
chr11_94576436_94576618	0.16	Acsf2	acyl-CoA synthetase family member 2	5749	0.12
chr16_87524872_87525038	0.16	Gm24891	predicted gene, 24891	3210	0.17
chrX_168779160_168779328	0.16	Gm15233	predicted gene 15233	3988	0.27
chr13_96460531_96460839	0.16	Ankdd1b	ankyrin repeat and death domain containing 1B	10426	0.14
chr2_119898379_119898542	0.16	Mga	MAX gene associated	1155	0.44
chr11_43992113_43992279	0.16	Gm12153	predicted gene 12153	33107	0.21
chr12_8379850_8380024	0.16	Gm48075	predicted gene, 48075	14272	0.16
chr1_131092973_131093137	0.15	Gm37084	predicted gene, 37084	906	0.48
chr2_25224743_25224915	0.15	Tubb4b	tubulin, beta 4B class IVB	127	0.85
chr17_64668680_64668845	0.15	Man2a1	mannosidase 2, alpha 1	44658	0.16
chr12_86793995_86794154	0.15	Gm10095	predicted gene 10095	52393	0.1
chr8_123727062_123727236	0.15	6030466F02Rik	RIKEN cDNA 6030466F02 gene	6809	0.08
chrX_11574471_11574649	0.15	Gm14515	predicted gene 14515	26794	0.22
chr11_83753876_83754040	0.15	Heatr6	HEAT repeat containing 6	71	0.94
chr13_69577241_69577408	0.15	Srd5a1	steroid 5 alpha-reductase 1	17505	0.12
chr2_167888871_167889131	0.15	Gm14319	predicted gene 14319	30416	0.13
chr5_138979896_138980396	0.15	Pdgfa	platelet derived growth factor, alpha	14135	0.17
chr12_21426260_21426445	0.14	Gm4419	predicted gene 4419	5593	0.17
chr6_90475971_90476128	0.14	Gm44421	predicted gene, 44421	2417	0.16
chr8_85493343_85493503	0.14	Gpt2	glutamic pyruvate transaminase (alanine aminotransferase) 2	814	0.6
chr5_138823785_138824155	0.14	Gm5294	predicted gene 5294	3890	0.23
chr2_70475906_70476144	0.13	Sp5	trans-acting transcription factor 5	1102	0.41
chr19_53076271_53076445	0.13	1700054A03Rik	RIKEN cDNA 1700054A03 gene	106	0.96
chr5_99526510_99527092	0.13	Gm16227	predicted gene 16227	16119	0.19
chr12_3959908_3960075	0.13	Pomc	pro-opiomelanocortin-alpha	5021	0.16
chr15_22046405_22046937	0.13	Gm49187	predicted gene, 49187	88239	0.1
chr7_79466451_79467019	0.13	Gm10616	predicted gene 10616	326	0.49
chr11_98935186_98935341	0.13	Rara	retinoic acid receptor, alpha	2435	0.17
chr16_23996527_23996692	0.13	Bcl6	B cell leukemia/lymphoma 6	7757	0.17
chr18_46804511_46804701	0.13	Gm49972	predicted gene, 49972	33281	0.1
chr6_97278036_97278202	0.13	Frmd4b	FERM domain containing 4B	13142	0.18
chr12_26401660_26402061	0.13	Rnf144a	ring finger protein 144A	4587	0.18
chr2_172961302_172961478	0.13	Spo11	SPO11 meiotic protein covalently bound to DSB	16310	0.15
chr10_76576688_76577047	0.13	Ftcd	formiminotransferase cyclodeaminase	1215	0.33
chr11_109545590_109545763	0.13	Arsg	arylsulfatase G	1922	0.3
chr2_77515804_77515970	0.13	Zfp385b	zinc finger protein 385B	3648	0.32
chr6_143100150_143100314	0.13	C2cd5	C2 calcium-dependent domain containing 5	91	0.96
chr15_59046761_59047065	0.12	Mtss1	MTSS I-BAR domain containing 1	6316	0.23
chr5_122518398_122518573	0.12	Gm22965	predicted gene, 22965	11696	0.1
chr8_120275994_120276315	0.12	Gse1	genetic suppressor element 1, coiled-coil protein	47698	0.12
chr15_64195944_64196287	0.12	Asap1	ArfGAP with SH3 domain, ankyrin repeat and PH domain1	12376	0.24
chr1_36536444_36536641	0.12	Ankrd23	ankyrin repeat domain 23	21	0.94
chr16_24223745_24224269	0.12	Gm31814	predicted gene, 31814	7483	0.23
chr4_37093076_37093227	0.12	Taf9-ps	TATA-box binding protein associated factor 9, pseudogene	46723	0.17
chr5_90464660_90465223	0.12	Alb	albumin	2241	0.25
chr5_122802424_122802664	0.12	Anapc5	anaphase-promoting complex subunit 5	78	0.96
chr7_83892128_83892320	0.12	Gm49493	predicted gene, 49493	38	0.57
chr9_32540170_32540338	0.12	Fli1	Friend leukemia integration 1	1341	0.31
chr18_34117842_34118226	0.12	Gm5238	predicted gene 5238	7683	0.17
chr8_69399199_69399538	0.12	Gm25661	predicted gene, 25661	357	0.82
chr2_83648966_83649145	0.11	Zc3h15	zinc finger CCCH-type containing 15	4432	0.24
chr1_69634071_69634222	0.11	Gm28112	predicted gene 28112	27915	0.17
chr12_112586365_112586574	0.11	Inf2	inverted formin, FH2 and WH2 domain containing	2315	0.23
chr10_111795867_111796218	0.11	Gm47865	predicted gene, 47865	3709	0.16
chr11_72940971_72941129	0.11	Gm44467	predicted gene, 44467	12057	0.13
chr3_39944706_39944868	0.11	Gm42785	predicted gene 42785	121210	0.06
chr10_75789893_75790050	0.11	Gstt1	glutathione S-transferase, theta 1	7598	0.09
chr4_100377331_100377511	0.11	Gm12706	predicted gene 12706	15362	0.26
chr19_47511131_47511282	0.11	Gm19557	predicted gene, 19557	1776	0.29
chr13_24049473_24049634	0.11	Carmil1	capping protein regulator and myosin 1 linker 1	9766	0.17
chr9_77768228_77768406	0.11	Gclc	glutamate-cysteine ligase, catalytic subunit	2175	0.24
chr14_11591449_11591619	0.11	Ptprg	protein tyrosine phosphatase, receptor type, G	37953	0.17
chr5_129019617_129019788	0.11	Ran	RAN, member RAS oncogene family	367	0.88
chr17_46725800_46726019	0.11	Gnmt	glycine N-methyltransferase	793	0.43
chr11_45178287_45178504	0.10	Gm38087	predicted gene, 38087	11477	0.2
chr5_117380230_117380381	0.10	Rfc5	replication factor C (activator 1) 5	89	0.95
chr19_41277479_41277665	0.10	Tm9sf3	transmembrane 9 superfamily member 3	13575	0.24
chr4_60516308_60516518	0.10	Mup-ps6	major urinary protein, pseudogene 6	1048	0.41
chr19_6340387_6340875	0.10	Map4k2	mitogen-activated protein kinase kinase kinase kinase 2	504	0.46
chr19_41332343_41332496	0.10	Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	52677	0.13

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax1_Pax9

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:0097477	lateral motor column neuron migration(GO:0097477)
0.1	0.3	GO:0021648	vestibulocochlear nerve morphogenesis(GO:0021648)
0.1	0.2	GO:0042126	nitrate metabolic process(GO:0042126)
0.1	0.2	GO:0015817	histidine transport(GO:0015817)
0.1	0.2	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.1	0.2	GO:1903223	positive regulation of oxidative stress-induced neuron death(GO:1903223)
0.0	0.5	GO:0002934	desmosome organization(GO:0002934)
0.0	0.1	GO:0021699	cerebellar cortex maturation(GO:0021699)
0.0	0.2	GO:0010040	response to iron(II) ion(GO:0010040)
0.0	0.1	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.2	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.1	GO:1903011	negative regulation of bone development(GO:1903011)
0.0	0.2	GO:0010572	positive regulation of platelet activation(GO:0010572)
0.0	0.1	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.1	GO:0006435	threonyl-tRNA aminoacylation(GO:0006435)
0.0	0.1	GO:0061086	negative regulation of histone H3-K27 methylation(GO:0061086)
0.0	0.1	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:1901740	negative regulation of myoblast fusion(GO:1901740)
0.0	0.2	GO:0006744	ubiquinone biosynthetic process(GO:0006744)
0.0	0.1	GO:0070094	positive regulation of glucagon secretion(GO:0070094)
0.0	0.1	GO:1901844	regulation of cell communication by electrical coupling involved in cardiac conduction(GO:1901844)
0.0	0.1	GO:0019852	L-ascorbic acid metabolic process(GO:0019852)
0.0	0.1	GO:0042851	L-alanine metabolic process(GO:0042851)
0.0	0.1	GO:0010637	negative regulation of mitochondrial fusion(GO:0010637)
0.0	0.1	GO:0052041	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.3	GO:0031163	iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0	0.1	GO:0032383	regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
0.0	0.1	GO:1902570	protein localization to nucleolus(GO:1902570)
0.0	0.3	GO:0035025	positive regulation of Rho protein signal transduction(GO:0035025)
0.0	0.1	GO:0086046	membrane depolarization during SA node cell action potential(GO:0086046)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.1	GO:0015755	fructose transport(GO:0015755)
0.0	0.1	GO:0071879	positive regulation of adrenergic receptor signaling pathway(GO:0071879)
0.0	0.1	GO:0071895	odontoblast differentiation(GO:0071895)
0.0	0.1	GO:0045896	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.0	GO:2000832	negative regulation of steroid hormone secretion(GO:2000832) negative regulation of corticosteroid hormone secretion(GO:2000847) negative regulation of glucocorticoid secretion(GO:2000850)
0.0	0.2	GO:0007097	nuclear migration(GO:0007097)
0.0	0.0	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.0	0.0	GO:2000591	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:0035793) regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway(GO:1900238) positive regulation of metanephric mesenchymal cell migration(GO:2000591)
0.0	0.2	GO:0032012	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.2	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.0	GO:0001692	histamine metabolic process(GO:0001692)
0.0	0.1	GO:0006532	aspartate biosynthetic process(GO:0006532)
0.0	0.1	GO:0051151	negative regulation of smooth muscle cell differentiation(GO:0051151)
0.0	0.0	GO:1900748	positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0	0.2	GO:0033327	Leydig cell differentiation(GO:0033327)
0.0	0.1	GO:1900264	regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.0	0.1	GO:0071051	polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.0	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.0	GO:0032485	regulation of Ral protein signal transduction(GO:0032485)
0.0	0.1	GO:0006729	tetrahydrobiopterin biosynthetic process(GO:0006729)
0.0	0.1	GO:1903297	regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
0.0	0.0	GO:2000611	positive regulation of thyroid hormone generation(GO:2000611)
0.0	0.2	GO:0006767	water-soluble vitamin metabolic process(GO:0006767)
0.0	0.1	GO:0009226	nucleotide-sugar biosynthetic process(GO:0009226)
0.0	0.0	GO:0036091	positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0036091)
0.0	0.0	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0	0.0	GO:0006982	response to lipid hydroperoxide(GO:0006982)
0.0	0.0	GO:0006548	histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
0.0	0.1	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.0	GO:0006842	tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.4	GO:0032584	growth cone membrane(GO:0032584)
0.0	0.1	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0031074	nucleocytoplasmic shuttling complex(GO:0031074)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.0	0.1	GO:0034750	Scrib-APC-beta-catenin complex(GO:0034750)
0.0	0.1	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.0	0.1	GO:0042583	chromaffin granule(GO:0042583)
0.0	0.1	GO:0061689	tricellular tight junction(GO:0061689)
0.0	0.1	GO:0031258	lamellipodium membrane(GO:0031258)
0.0	0.1	GO:0048500	signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.1	GO:0044322	endoplasmic reticulum quality control compartment(GO:0044322)
0.0	0.1	GO:1990696	USH2 complex(GO:1990696)
0.0	0.2	GO:0071565	nBAF complex(GO:0071565)
0.0	0.0	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.2	GO:0033276	transcription factor TFTC complex(GO:0033276)
0.0	0.0	GO:0097413	Lewy body(GO:0097413)
0.0	0.0	GO:0030313	cell outer membrane(GO:0009279) cell envelope(GO:0030313) external encapsulating structure part(GO:0044462)
0.0	0.0	GO:0030868	smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1901612	cardiolipin binding(GO:1901612)
0.1	0.2	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.1	0.3	GO:0070326	very-low-density lipoprotein particle receptor binding(GO:0070326)
0.1	0.4	GO:0046790	virion binding(GO:0046790)
0.1	0.2	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.3	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.2	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.2	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	0.1	GO:0008427	calcium-dependent protein kinase inhibitor activity(GO:0008427)
0.0	0.1	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0061676	importin-alpha family protein binding(GO:0061676)
0.0	0.1	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.2	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0004829	threonine-tRNA ligase activity(GO:0004829)
0.0	0.1	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.3	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.1	GO:0008312	7S RNA binding(GO:0008312)
0.0	0.1	GO:0004069	L-aspartate:2-oxoglutarate aminotransferase activity(GO:0004069)
0.0	0.1	GO:0097200	cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.0	0.1	GO:0086056	voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056)
0.0	0.1	GO:0019870	potassium channel inhibitor activity(GO:0019870)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.2	GO:0030955	potassium ion binding(GO:0030955)
0.0	0.1	GO:0015349	thyroid hormone transmembrane transporter activity(GO:0015349)
0.0	0.1	GO:0016361	activin receptor activity, type I(GO:0016361)
0.0	0.1	GO:0005225	volume-sensitive anion channel activity(GO:0005225)
0.0	0.0	GO:0008321	Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0	0.1	GO:0048403	brain-derived neurotrophic factor binding(GO:0048403)
0.0	0.4	GO:0017112	Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0	0.0	GO:0033829	O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829)
0.0	0.0	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0003689	DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.0	0.0	GO:0050816	phosphothreonine binding(GO:0050816)
0.0	0.2	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0	0.0	GO:0034548	N-cyclopropylmelamine deaminase activity(GO:0034547) N-cyclopropylammeline deaminase activity(GO:0034548) N-cyclopropylammelide alkylamino hydrolase activity(GO:0034549) 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity(GO:0043723) tRNA-specific adenosine-37 deaminase activity(GO:0043829) archaeal-specific GTP cyclohydrolase activity(GO:0044682) tRNA-specific adenosine-34 deaminase activity(GO:0052717)
0.0	0.3	GO:0051537	2 iron, 2 sulfur cluster binding(GO:0051537)
0.0	0.3	GO:0001106	RNA polymerase II transcription corepressor activity(GO:0001106)
0.0	0.1	GO:0005049	nuclear export signal receptor activity(GO:0005049)
0.0	0.1	GO:0031432	titin binding(GO:0031432)
0.0	0.1	GO:0008599	protein phosphatase type 1 regulator activity(GO:0008599)
0.0	0.0	GO:0015142	citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)

Gene overrepresentation in curated gene sets: canonical pathways category:

Total log-likelihood	Term	Description
0.2	PID VEGFR1 2 PATHWAY	Signaling events mediated by VEGFR1 and VEGFR2
0.1	PID CDC42 PATHWAY	CDC42 signaling events
0.1	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.3	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.2	REACTOME RECYCLING OF BILE ACIDS AND SALTS	Genes involved in Recycling of bile acids and salts
0.0	REACTOME GAP JUNCTION TRAFFICKING	Genes involved in Gap junction trafficking
0.2	REACTOME ERKS ARE INACTIVATED	Genes involved in ERKs are inactivated
0.2	REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS	Genes involved in ABCA transporters in lipid homeostasis
0.1	REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS	Genes involved in Apoptotic cleavage of cell adhesion proteins
0.2	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation