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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Pax3

Z-value: 1.36

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Transcription factors associated with Pax3

Gene Symbol	Gene ID	Gene Info
Pax3 Ensembl NCBI MGI UniProt	ENSMUSG00000004872.9	Pax3

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Pax3	chr1_78140703_78141066	55954	0.136991	0.81	5.2e-02	Click!
Pax3	chr1_78093772_78093929	102988	0.067501	0.76	8.1e-02	Click!
Pax3	chr1_78142712_78143028	53968	0.141145	-0.59	2.2e-01	Click!
Pax3	chr1_78143284_78143452	53470	0.142201	0.59	2.2e-01	Click!
Pax3	chr1_78143066_78143229	53691	0.141731	0.45	3.6e-01	Click!

Activity of the Pax3 motif across conditions

Conditions sorted by the z-value of the Pax3 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr16_30953629_30953810	0.86	Gm46565	predicted gene, 46565	18090	0.15
chr1_40217416_40217567	0.83	Il1r1	interleukin 1 receptor, type I	7589	0.21
chr7_107574446_107574681	0.80	Olfml1	olfactomedin-like 1	6797	0.16
chr18_11858447_11858616	0.68	Cables1	CDK5 and Abl enzyme substrate 1	14231	0.16
chr2_134489871_134490022	0.64	Hao1	hydroxyacid oxidase 1, liver	64361	0.14
chr11_109734187_109734610	0.62	Fam20a	family with sequence similarity 20, member A	12119	0.17
chr15_7194329_7194480	0.53	Egflam	EGF-like, fibronectin type III and laminin G domains	28665	0.2
chr12_33285610_33285770	0.51	Atxn7l1	ataxin 7-like 1	16825	0.2
chr2_115736424_115736575	0.51	Mir1951	microRNA 1951	97774	0.08
chr10_75051471_75051652	0.47	Bcr	BCR activator of RhoGEF and GTPase	9031	0.15
chr2_4895714_4895931	0.47	Sephs1	selenophosphate synthetase 1	11438	0.15
chr13_56354793_56354953	0.46	Gm10782	predicted gene 10782	8027	0.15
chr3_127891231_127891382	0.43	Fam241a	family with sequence similarity 241, member A	4982	0.14
chr5_125522928_125523080	0.42	Aacs	acetoacetyl-CoA synthetase	7761	0.16
chr8_115089778_115090403	0.42	Gm22556	predicted gene, 22556	37177	0.23
chr6_51702213_51702384	0.41	Gm38811	predicted gene, 38811	8783	0.25
chr19_37213872_37214035	0.41	Marchf5	membrane associated ring-CH-type finger 5	3237	0.17
chr16_70320876_70321204	0.41	Gbe1	glucan (1,4-alpha-), branching enzyme 1	6906	0.26
chr15_81432149_81432317	0.41	Gm17025	predicted gene 17025	13045	0.11
chr15_41494169_41494320	0.41	Oxr1	oxidation resistance 1	45217	0.2
chr1_67234188_67234342	0.39	Gm15668	predicted gene 15668	14935	0.21
chr19_40156899_40157166	0.38	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	30254	0.13
chr15_67780972_67781123	0.38	Gm49408	predicted gene, 49408	92781	0.09
chr5_63953741_63953922	0.38	Rell1	RELT-like 1	14992	0.15
chr9_71694307_71694467	0.38	Cgnl1	cingulin-like 1	46037	0.14
chr17_32270584_32270735	0.38	Brd4	bromodomain containing 4	1706	0.26
chr4_49544305_49544456	0.38	Aldob	aldolase B, fructose-bisphosphate	4494	0.16
chr1_93029521_93029757	0.37	Kif1a	kinesin family member 1A	2434	0.2
chr13_37537164_37537329	0.37	Lncbate6	brown adipose tissue enriched long noncoding RNA 6	4111	0.13
chr2_168314984_168315140	0.37	Gm14262	predicted gene 14262	19941	0.13
chr15_84707077_84707228	0.36	Arhgap8	Rho GTPase activating protein 8	12900	0.16
chr5_32441483_32441679	0.36	Ppp1cb	protein phosphatase 1 catalytic subunit beta	17262	0.11
chr6_51698327_51698491	0.36	Gm38811	predicted gene, 38811	12672	0.24
chr5_90431005_90431358	0.36	Alb	albumin	29716	0.13
chr7_35127036_35127350	0.35	Gm45091	predicted gene 45091	7588	0.1
chr14_16483661_16483812	0.35	Top2b	topoisomerase (DNA) II beta	58308	0.12
chr6_54199490_54199996	0.35	Gm15526	predicted gene 15526	22060	0.17
chr8_128654178_128654469	0.35	Gm45746	predicted gene 45746	10	0.97
chr11_100493828_100493979	0.35	Acly	ATP citrate lyase	296	0.81
chr2_165825114_165825267	0.34	Zmynd8	zinc finger, MYND-type containing 8	26932	0.14
chr13_90896944_90897260	0.34	Atp6ap1l	ATPase, H+ transporting, lysosomal accessory protein 1-like	1722	0.38
chr17_24116369_24116555	0.34	Pdpk1	3-phosphoinositide dependent protein kinase 1	4332	0.11
chr15_11505228_11505379	0.33	Tars	threonyl-tRNA synthetase	105638	0.06
chr7_71708283_71708442	0.32	Gm44688	predicted gene 44688	2286	0.26
chr8_4837839_4838020	0.32	Gm44961	predicted gene 44961	16699	0.13
chr10_105404051_105404220	0.32	Gm48203	predicted gene, 48203	9849	0.19
chr10_4112716_4112889	0.32	Gm25515	predicted gene, 25515	8489	0.22
chr11_16830831_16831057	0.32	Egfros	epidermal growth factor receptor, opposite strand	242	0.94
chr14_63223276_63223490	0.32	Gata4	GATA binding protein 4	9776	0.16
chr5_52360112_52360263	0.32	Sod3	superoxide dismutase 3, extracellular	3604	0.19
chr6_52606460_52606970	0.31	Gm44434	predicted gene, 44434	3470	0.19
chr4_119589534_119589697	0.31	Foxj3	forkhead box J3	31727	0.1
chr13_56613401_56613633	0.31	Tgfbi	transforming growth factor, beta induced	3931	0.22
chr1_62019757_62019954	0.31	Gm29640	predicted gene 29640	38648	0.18
chr1_39731626_39731803	0.31	Rfx8	regulatory factor X 8	10717	0.2
chr1_37026954_37027105	0.31	Vwa3b	von Willebrand factor A domain containing 3B	433	0.82
chr12_84161882_84162074	0.31	Elmsan1	ELM2 and Myb/SANT-like domain containing 1	1840	0.21
chr2_58790704_58790855	0.30	Upp2	uridine phosphorylase 2	25454	0.18
chr3_57696895_57697058	0.29	Gm43098	predicted gene 43098	500	0.68
chr9_110676644_110676946	0.29	Gm35715	predicted gene, 35715	1841	0.21
chr4_42805039_42805190	0.29	Ccl21a	chemokine (C-C motif) ligand 21A (serine)	31121	0.1
chr11_44461636_44461815	0.29	Ublcp1	ubiquitin-like domain containing CTD phosphatase 1	372	0.84
chr14_114875214_114875365	0.29	Gm49010	predicted gene, 49010	1221	0.47
chr2_11598213_11598381	0.29	Rbm17	RNA binding motif protein 17	4965	0.15
chr19_18181186_18181345	0.28	Gm18610	predicted gene, 18610	24530	0.25
chr14_33018854_33019018	0.28	Wdfy4	WD repeat and FYVE domain containing 4	4401	0.24
chr7_35127993_35128152	0.28	Gm45091	predicted gene 45091	8467	0.1
chr3_108830802_108830953	0.28	Stxbp3	syntaxin binding protein 3	9574	0.15
chr5_64389400_64389576	0.28	Gm43837	predicted gene 43837	6034	0.16
chr9_46049413_46049714	0.28	Sik3	SIK family kinase 3	36563	0.11
chr9_70318576_70318770	0.28	Mir5626	microRNA 5626	87080	0.07
chr18_7657901_7658087	0.28	Mpp7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	31128	0.17
chr5_110857209_110857384	0.28	Chek2	checkpoint kinase 2	8975	0.11
chr2_50332059_50332279	0.28	Gm13483	predicted gene 13483	35264	0.15
chr7_44473035_44473343	0.28	5430431A17Rik	RIKEN cDNA 5430431A17 gene	349	0.67
chr7_6244451_6244617	0.28	Epp13	epididymal protein 13	8176	0.11
chr2_4873838_4873989	0.27	Sephs1	selenophosphate synthetase 1	7651	0.17
chr1_153741335_153741540	0.27	Rgs16	regulator of G-protein signaling 16	1088	0.32
chr14_69628830_69628981	0.27	Gm27177	predicted gene 27177	11369	0.11
chr11_3191105_3191256	0.27	Sfi1	Sfi1 homolog, spindle assembly associated (yeast)	2124	0.19
chr2_119408322_119408473	0.27	Ino80	INO80 complex subunit	31283	0.12
chr11_23459880_23460062	0.27	Usp34	ubiquitin specific peptidase 34	1894	0.26
chr16_70352880_70353045	0.27	Gbe1	glucan (1,4-alpha-), branching enzyme 1	38828	0.19
chr7_104400820_104400986	0.27	Trim30c	tripartite motif-containing 30C	66	0.94
chr14_69410565_69410723	0.26	Gm38378	predicted gene, 38378	12873	0.11
chr12_84762512_84762714	0.26	Npc2	NPC intracellular cholesterol transporter 2	73	0.96
chr10_64071704_64071882	0.26	Lrrtm3	leucine rich repeat transmembrane neuronal 3	18454	0.28
chr15_83202527_83202771	0.26	7530414M10Rik	RIKEN cDNA 7530414M10 gene	26204	0.1
chr7_81641263_81641414	0.26	Homer2	homer scaffolding protein 2	22433	0.11
chr5_125487930_125488123	0.26	Gm27551	predicted gene, 27551	8649	0.13
chr10_111364307_111364473	0.25	Gm40761	predicted gene, 40761	27266	0.17
chr16_34961005_34961156	0.25	E130310I04Rik	RIKEN cDNA E130310I04 gene	2086	0.28
chr2_15112887_15113050	0.25	Gm13313	predicted gene 13313	14632	0.17
chr12_99426306_99426461	0.25	Foxn3	forkhead box N3	13778	0.17
chr13_109599464_109599649	0.25	Pde4d	phosphodiesterase 4D, cAMP specific	18151	0.3
chr9_30613779_30614132	0.25	Gm47716	predicted gene, 47716	18632	0.24
chr19_23170256_23170407	0.24	Mir1192	microRNA 1192	20900	0.15
chr6_50305009_50305231	0.24	Osbpl3	oxysterol binding protein-like 3	4766	0.27
chr19_10895844_10896002	0.24	Prpf19	pre-mRNA processing factor 19	509	0.64
chr6_7876922_7877112	0.24	Gm22276	predicted gene, 22276	2546	0.22
chr10_20739880_20740054	0.23	Pde7b	phosphodiesterase 7B	14889	0.2
chr16_95579480_95579639	0.23	Erg	ETS transcription factor	7034	0.29
chr6_93348262_93348414	0.23	Gm25094	predicted gene, 25094	12750	0.26
chr3_131105917_131106088	0.23	Lef1	lymphoid enhancer binding factor 1	4469	0.19
chr1_106309746_106309897	0.23	Phlpp1	PH domain and leucine rich repeat protein phosphatase 1	7417	0.25
chr19_40164076_40164449	0.23	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	23024	0.14
chr1_90963133_90963297	0.23	Rab17	RAB17, member RAS oncogene family	4402	0.16
chr9_65196176_65196352	0.23	Gm25313	predicted gene, 25313	423	0.64
chr5_90471470_90471733	0.23	Alb	albumin	8901	0.15
chr10_87858971_87859139	0.22	Igf1	insulin-like growth factor 1	13	0.98
chr8_115935040_115935191	0.22	Gm45733	predicted gene 45733	36956	0.23
chr16_32645465_32645635	0.22	Tnk2	tyrosine kinase, non-receptor, 2	591	0.68
chr5_145465006_145465183	0.22	Cyp3a16	cytochrome P450, family 3, subfamily a, polypeptide 16	4629	0.2
chr19_38372543_38372709	0.22	Gm50155	predicted gene, 50155	12888	0.14
chr3_82110699_82110861	0.22	Mir7010	microRNA 7010	4471	0.22
chr1_164632885_164633038	0.22	Gm37754	predicted gene, 37754	1204	0.46
chr5_91214401_91214579	0.22	Gm23092	predicted gene, 23092	3514	0.28
chr4_87880355_87880506	0.22	Mllt3	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3	5888	0.31
chr2_25224743_25224915	0.22	Tubb4b	tubulin, beta 4B class IVB	127	0.85
chr15_91203650_91203811	0.22	CN725425	cDNA sequence CN725425	4236	0.24
chr1_64802706_64802963	0.22	Plekhm3	pleckstrin homology domain containing, family M, member 3	33930	0.14
chr5_33467286_33467498	0.22	Gm43851	predicted gene 43851	29928	0.14
chr6_72694339_72694529	0.22	Gm15402	predicted gene 15402	4780	0.14
chr13_85126519_85126671	0.21	Gm4076	predicted gene 4076	919	0.57
chr9_71217044_71217463	0.21	Aldh1a2	aldehyde dehydrogenase family 1, subfamily A2	1464	0.43
chr8_121943229_121943385	0.21	Car5a	carbonic anhydrase 5a, mitochondrial	1597	0.22
chr9_22800849_22801004	0.21	Gm27639	predicted gene, 27639	28091	0.22
chr4_8361870_8362071	0.21	Gm37386	predicted gene, 37386	92277	0.08
chr11_70713419_70713657	0.21	Mir6925	microRNA 6925	7548	0.08
chr8_48517142_48517293	0.21	Tenm3	teneurin transmembrane protein 3	38096	0.21
chr9_25526348_25526499	0.21	Gm25861	predicted gene, 25861	12782	0.19
chr6_31339858_31340224	0.21	Gm14532	predicted gene 14532	16702	0.14
chr5_115775514_115775665	0.21	Gm13841	predicted gene 13841	26570	0.14
chr18_70440225_70440381	0.21	Gm45879	predicted gene 45879	6447	0.19
chr10_125490636_125490927	0.21	Gm9102	predicted gene 9102	21750	0.25
chr10_43896146_43896340	0.21	Qrsl1	glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1	702	0.66
chr13_41813363_41813628	0.21	1700061E18Rik	RIKEN cDNA 1700061E18 gene	12712	0.15
chr3_101601625_101602386	0.21	Atp1a1	ATPase, Na+/K+ transporting, alpha 1 polypeptide	2679	0.24
chr6_128549526_128549695	0.21	A2ml1	alpha-2-macroglobulin like 1	3668	0.12
chr13_59498313_59498500	0.21	Agtpbp1	ATP/GTP binding protein 1	15748	0.16
chr7_14413903_14414054	0.20	Sult2a8	sulfotransferase family 2A, dehydroepiandrosterone (DHEA)-preferring, member 8	22469	0.14
chr5_148777254_148777431	0.20	4930505K14Rik	RIKEN cDNA 4930505K14 gene	621	0.67
chr8_91593939_91594090	0.20	Gm45294	predicted gene 45294	14726	0.14
chr8_78021619_78021802	0.20	Gm29895	predicted gene, 29895	22300	0.24
chr11_108309880_108310049	0.20	Apoh	apolipoprotein H	33390	0.16
chr15_10985300_10985768	0.20	Amacr	alpha-methylacyl-CoA racemase	2128	0.26
chr14_30011884_30012221	0.20	Chdh	choline dehydrogenase	2881	0.15
chr2_31500949_31501119	0.20	Ass1	argininosuccinate synthetase 1	308	0.89
chr14_120705561_120705745	0.20	Rpl19-ps5	ribosomal protein L19, pseudogene 5	7425	0.21
chr10_95837027_95837208	0.20	Gm33543	predicted gene, 33543	5779	0.13
chr19_20609347_20609744	0.20	Aldh1a1	aldehyde dehydrogenase family 1, subfamily A1	7584	0.22
chr4_107999051_107999218	0.20	Slc1a7	solute carrier family 1 (glutamate transporter), member 7	10883	0.13
chr12_40034619_40034798	0.20	Arl4a	ADP-ribosylation factor-like 4A	2659	0.25
chr2_74015081_74015248	0.20	Gm13668	predicted gene 13668	54495	0.12
chr17_29496086_29496540	0.20	Pim1	proviral integration site 1	2906	0.15
chr2_145822849_145823024	0.20	Rin2	Ras and Rab interactor 2	647	0.75
chr3_86013918_86014185	0.19	Prss48	protease, serine 48	11560	0.13
chr10_127970687_127970872	0.19	Gm47949	predicted gene, 47949	9223	0.09
chr2_91631313_91631664	0.19	F2	coagulation factor II	4907	0.12
chr5_116435060_116435476	0.19	Srrm4os	serine/arginine repetitive matrix 4, opposite strand	3452	0.16
chr15_79685106_79685264	0.19	Josd1	Josephin domain containing 1	2734	0.12
chr2_120540080_120540275	0.19	Zfp106	zinc finger protein 106	317	0.86
chr2_122258184_122258335	0.19	Sord	sorbitol dehydrogenase	23510	0.09
chr12_3846090_3846255	0.19	Dnmt3a	DNA methyltransferase 3A	3463	0.22
chr11_38679459_38679621	0.19	Gm23520	predicted gene, 23520	118737	0.07
chr1_157507362_157507522	0.19	Sec16b	SEC16 homolog B (S. cerevisiae)	632	0.67
chr10_28524122_28524273	0.19	Ptprk	protein tyrosine phosphatase, receptor type, K	35954	0.22
chr1_9985700_9985867	0.19	Ppp1r42	protein phosphatase 1, regulatory subunit 42	91	0.94
chr7_71872986_71873347	0.19	4930441H08Rik	RIKEN cDNA 4930441H08 gene	36527	0.18
chr10_87923075_87923294	0.19	Tyms-ps	thymidylate synthase, pseudogene	43663	0.12
chr5_3386445_3386622	0.19	Cdk6	cyclin-dependent kinase 6	42221	0.13
chr5_74316459_74316619	0.19	Gm15981	predicted gene 15981	495	0.77
chr19_31905786_31905989	0.19	Gm19241	predicted gene, 19241	7757	0.22
chr10_68179447_68179622	0.19	Arid5b	AT rich interactive domain 5B (MRF1-like)	42908	0.17
chr19_38399004_38399174	0.19	Slc35g1	solute carrier family 35, member G1	3048	0.21
chr15_59055272_59055945	0.19	Mtss1	MTSS I-BAR domain containing 1	144	0.97
chr5_143055727_143055894	0.19	Gm43378	predicted gene 43378	5767	0.15
chrX_161292140_161292301	0.19	Gm15262	predicted gene 15262	4764	0.25
chr4_124709849_124710395	0.18	Sf3a3	splicing factor 3a, subunit 3	4654	0.09
chr17_26123354_26123516	0.18	Mrpl28	mitochondrial ribosomal protein L28	65	0.93
chr7_141477112_141477277	0.18	Tspan4	tetraspanin 4	794	0.33
chr6_125319120_125319346	0.18	Scnn1a	sodium channel, nonvoltage-gated 1 alpha	1426	0.25
chr8_70212287_70212467	0.18	Slc25a42	solute carrier family 25, member 42	72	0.95
chr5_90450366_90450538	0.18	Alb	albumin	10445	0.16
chr7_132554752_132554903	0.18	Oat	ornithine aminotransferase	20891	0.15
chr2_114274553_114274847	0.18	Gm29234	predicted gene 29234	1265	0.55
chr1_13116391_13116585	0.18	Prdm14	PR domain containing 14	10675	0.15
chr1_38449538_38449710	0.18	Gm34727	predicted gene, 34727	37895	0.18
chr9_78513759_78514095	0.18	Gm47430	predicted gene, 47430	6619	0.13
chr1_84056873_84057054	0.18	Pid1	phosphotyrosine interaction domain containing 1	3710	0.31
chr11_119216234_119216406	0.18	Gm11752	predicted gene 11752	3840	0.14
chr13_99238383_99238564	0.18	Zfp366	zinc finger protein 366	53650	0.12
chr16_49887202_49887530	0.18	Cd47	CD47 antigen (Rh-related antigen, integrin-associated signal transducer)	20533	0.26
chr7_77787283_77787474	0.18	Gm23239	predicted gene, 23239	122942	0.06
chr13_81633136_81633428	0.18	Adgrv1	adhesion G protein-coupled receptor V1	128	0.96
chr4_55902839_55903035	0.18	Gm12519	predicted gene 12519	90802	0.09
chr7_68687331_68687482	0.18	Gm44692	predicted gene 44692	39061	0.15
chr7_99180189_99180656	0.18	Dgat2	diacylglycerol O-acyltransferase 2	129	0.94
chr9_96223410_96223561	0.18	Gm37195	predicted gene, 37195	4355	0.2
chr8_79288742_79288893	0.18	Mmaa	methylmalonic aciduria (cobalamin deficiency) type A	5863	0.17

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:1990314	cellular response to insulin-like growth factor stimulus(GO:1990314)
0.1	0.3	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.2	GO:0051182	coenzyme transport(GO:0051182)
0.1	0.2	GO:0048208	vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1	0.2	GO:0010046	response to mycotoxin(GO:0010046)
0.1	0.2	GO:0003419	growth plate cartilage chondrocyte proliferation(GO:0003419)
0.0	0.1	GO:0001757	somite specification(GO:0001757)
0.0	0.1	GO:1901509	regulation of endothelial tube morphogenesis(GO:1901509)
0.0	0.2	GO:0035864	response to potassium ion(GO:0035864) cellular response to potassium ion(GO:0035865)
0.0	0.2	GO:1902897	regulation of postsynaptic density protein 95 clustering(GO:1902897)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.1	GO:0070681	glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.0	0.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.0	0.1	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:0010986	positive regulation of lipoprotein particle clearance(GO:0010986)
0.0	0.2	GO:0060613	fat pad development(GO:0060613)
0.0	0.2	GO:0071276	cellular response to cadmium ion(GO:0071276)
0.0	0.1	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
0.0	0.2	GO:0048496	maintenance of organ identity(GO:0048496)
0.0	0.1	GO:0003289	atrial septum primum morphogenesis(GO:0003289)
0.0	0.2	GO:2000389	regulation of neutrophil extravasation(GO:2000389) positive regulation of neutrophil extravasation(GO:2000391)
0.0	0.1	GO:0045054	constitutive secretory pathway(GO:0045054)
0.0	0.1	GO:1902498	regulation of protein autoubiquitination(GO:1902498)
0.0	0.1	GO:0000707	meiotic DNA recombinase assembly(GO:0000707)
0.0	0.1	GO:0010835	regulation of protein ADP-ribosylation(GO:0010835)
0.0	0.1	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.1	GO:1902564	negative regulation of neutrophil activation(GO:1902564)
0.0	0.1	GO:0010728	regulation of hydrogen peroxide biosynthetic process(GO:0010728)
0.0	0.1	GO:2001171	positive regulation of ATP biosynthetic process(GO:2001171)
0.0	0.2	GO:0042904	9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.0	0.3	GO:0006107	oxaloacetate metabolic process(GO:0006107)
0.0	0.1	GO:0060061	Spemann organizer formation(GO:0060061)
0.0	0.1	GO:0035523	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.1	GO:0038171	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.1	GO:0032324	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.2	GO:0034058	endosomal vesicle fusion(GO:0034058)
0.0	0.1	GO:0006393	termination of mitochondrial transcription(GO:0006393)
0.0	0.1	GO:0061470	T follicular helper cell differentiation(GO:0061470)
0.0	0.1	GO:0061624	fructose catabolic process(GO:0006001) fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate(GO:0061624) glycolytic process through fructose-1-phosphate(GO:0061625)
0.0	0.0	GO:0034395	regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395)
0.0	0.1	GO:1902309	negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.0	0.2	GO:0032367	intracellular cholesterol transport(GO:0032367)
0.0	0.1	GO:0035609	C-terminal protein deglutamylation(GO:0035609)
0.0	0.1	GO:0030718	germ-line stem cell population maintenance(GO:0030718)
0.0	0.1	GO:0060160	negative regulation of dopamine receptor signaling pathway(GO:0060160)
0.0	0.0	GO:0006714	sesquiterpenoid metabolic process(GO:0006714)
0.0	0.2	GO:0009191	ribonucleoside diphosphate catabolic process(GO:0009191)
0.0	0.1	GO:2001271	negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.0	0.2	GO:0000244	spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0	0.1	GO:0042524	negative regulation of tyrosine phosphorylation of Stat5 protein(GO:0042524)
0.0	0.0	GO:0045917	positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0	0.1	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:1903416	response to glycoside(GO:1903416)
0.0	0.1	GO:0061084	negative regulation of protein refolding(GO:0061084)
0.0	0.1	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.0	0.0	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.1	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.0	0.0	GO:0008050	female courtship behavior(GO:0008050)
0.0	0.0	GO:0061152	trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
0.0	0.0	GO:0044860	protein localization to plasma membrane raft(GO:0044860)
0.0	0.1	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0	0.0	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.0	GO:0090038	negative regulation of protein kinase C signaling(GO:0090038)
0.0	0.1	GO:0045900	negative regulation of translational elongation(GO:0045900)
0.0	0.0	GO:0014873	response to muscle activity involved in regulation of muscle adaptation(GO:0014873)
0.0	0.0	GO:0006987	activation of signaling protein activity involved in unfolded protein response(GO:0006987)
0.0	0.0	GO:0006481	C-terminal protein methylation(GO:0006481)
0.0	0.1	GO:0043951	negative regulation of cAMP-mediated signaling(GO:0043951)
0.0	0.0	GO:0046292	formaldehyde metabolic process(GO:0046292)
0.0	0.1	GO:0071447	cellular response to hydroperoxide(GO:0071447)
0.0	0.1	GO:1902373	negative regulation of mRNA catabolic process(GO:1902373)
0.0	0.1	GO:0019800	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0	0.1	GO:1900103	positive regulation of endoplasmic reticulum unfolded protein response(GO:1900103)
0.0	0.0	GO:2000599	regulation of cyclin catabolic process(GO:2000598) negative regulation of cyclin catabolic process(GO:2000599)
0.0	0.1	GO:0032000	positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0	0.1	GO:0043983	histone H4-K12 acetylation(GO:0043983)
0.0	0.0	GO:2000670	positive regulation of dendritic cell apoptotic process(GO:2000670)
0.0	0.1	GO:0045876	positive regulation of sister chromatid cohesion(GO:0045876)
0.0	0.1	GO:0018406	protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
0.0	0.4	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.0	GO:0090283	regulation of protein glycosylation in Golgi(GO:0090283)
0.0	0.0	GO:1904124	microglial cell migration(GO:1904124) regulation of microglial cell migration(GO:1904139)
0.0	0.0	GO:0060336	negative regulation of response to interferon-gamma(GO:0060331) negative regulation of interferon-gamma-mediated signaling pathway(GO:0060336)
0.0	0.0	GO:0002254	kinin cascade(GO:0002254)
0.0	0.0	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.0	GO:0030210	heparin biosynthetic process(GO:0030210)
0.0	0.1	GO:0038165	oncostatin-M-mediated signaling pathway(GO:0038165)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0008228	opsonization(GO:0008228)
0.0	0.0	GO:0010248	establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.0	0.1	GO:0046499	S-adenosylmethioninamine metabolic process(GO:0046499)
0.0	0.1	GO:0048739	cardiac muscle fiber development(GO:0048739)
0.0	0.0	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.0	GO:0010912	regulation of isomerase activity(GO:0010911) positive regulation of isomerase activity(GO:0010912)
0.0	0.1	GO:0043353	enucleate erythrocyte differentiation(GO:0043353)
0.0	0.0	GO:0033031	positive regulation of neutrophil apoptotic process(GO:0033031)
0.0	0.1	GO:1901725	regulation of histone deacetylase activity(GO:1901725)
0.0	0.1	GO:0006012	galactose metabolic process(GO:0006012)
0.0	0.0	GO:0071896	protein localization to adherens junction(GO:0071896)
0.0	0.0	GO:0060948	cardiac vascular smooth muscle cell development(GO:0060948)
0.0	0.0	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.0	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.0	GO:0007171	activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0	0.0	GO:0071883	activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883)
0.0	0.0	GO:0060696	regulation of phospholipid catabolic process(GO:0060696)
0.0	0.1	GO:1902993	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0	0.1	GO:0006610	ribosomal protein import into nucleus(GO:0006610)
0.0	0.0	GO:0009182	purine deoxyribonucleoside diphosphate metabolic process(GO:0009182) dGDP metabolic process(GO:0046066)
0.0	0.0	GO:1903750	regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.0	0.0	GO:0006573	valine metabolic process(GO:0006573)
0.0	0.0	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.0	GO:0072194	kidney smooth muscle tissue development(GO:0072194)
0.0	0.0	GO:1903279	regulation of calcium:sodium antiporter activity(GO:1903279)
0.0	0.1	GO:0042448	progesterone metabolic process(GO:0042448)
0.0	0.1	GO:0007567	parturition(GO:0007567)
0.0	0.0	GO:1902263	apoptotic process involved in embryonic digit morphogenesis(GO:1902263)
0.0	0.0	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.1	GO:0007379	segment specification(GO:0007379)
0.0	0.1	GO:0030150	protein import into mitochondrial matrix(GO:0030150)
0.0	0.0	GO:0021529	spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530)
0.0	0.1	GO:0035166	post-embryonic hemopoiesis(GO:0035166)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0042567	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0030956	glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.0	0.2	GO:0045298	tubulin complex(GO:0045298)
0.0	0.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.0	0.1	GO:0002142	stereocilia ankle link complex(GO:0002142)
0.0	0.2	GO:0002177	manchette(GO:0002177)
0.0	0.2	GO:0030056	hemidesmosome(GO:0030056)
0.0	0.1	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.0	0.1	GO:0033063	Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.0	0.1	GO:0045098	type III intermediate filament(GO:0045098)
0.0	0.0	GO:0034679	integrin alpha9-beta1 complex(GO:0034679)
0.0	0.1	GO:1990907	beta-catenin-TCF complex(GO:1990907)
0.0	0.1	GO:0016602	CCAAT-binding factor complex(GO:0016602)
0.0	0.1	GO:0097543	ciliary inversin compartment(GO:0097543)
0.0	0.0	GO:0035985	senescence-associated heterochromatin focus(GO:0035985)
0.0	0.1	GO:0001652	granular component(GO:0001652)
0.0	0.2	GO:0070852	cell body fiber(GO:0070852)
0.0	0.1	GO:0008024	cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.0	0.0	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.0	GO:1990597	AIP1-IRE1 complex(GO:1990597)
0.0	0.1	GO:0005688	U6 snRNP(GO:0005688)
0.0	0.0	GO:0097149	centralspindlin complex(GO:0097149)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.0	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.0	0.1	GO:0030689	Noc complex(GO:0030689)
0.0	0.1	GO:0000138	Golgi trans cisterna(GO:0000138)
0.0	0.0	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.0	GO:0044354	pinosome(GO:0044352) macropinosome(GO:0044354)
0.0	0.0	GO:0070545	PeBoW complex(GO:0070545)
0.0	0.2	GO:0001741	XY body(GO:0001741)
0.0	0.2	GO:0030014	CCR4-NOT complex(GO:0030014)
0.0	0.0	GO:1990130	Iml1 complex(GO:1990130)
0.0	0.1	GO:0005890	sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0	0.1	GO:0005827	polar microtubule(GO:0005827)
0.0	0.3	GO:0055038	recycling endosome membrane(GO:0055038)
0.0	0.1	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.1	GO:0000124	SAGA complex(GO:0000124)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0050252	retinol O-fatty-acyltransferase activity(GO:0050252)
0.1	0.2	GO:0005347	ATP transmembrane transporter activity(GO:0005347)
0.1	0.2	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.2	GO:0046912	transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.0	0.1	GO:0050567	glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.0	0.1	GO:0048408	epidermal growth factor binding(GO:0048408)
0.0	0.2	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.2	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.2	GO:0001515	opioid peptide activity(GO:0001515)
0.0	0.2	GO:0004128	cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.0	0.1	GO:0034714	type III transforming growth factor beta receptor binding(GO:0034714)
0.0	0.1	GO:0008970	phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
0.0	0.3	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.1	GO:1990829	C-rich single-stranded DNA binding(GO:1990829)
0.0	0.1	GO:0070053	thrombospondin receptor activity(GO:0070053)
0.0	0.1	GO:0030292	protein tyrosine kinase inhibitor activity(GO:0030292)
0.0	0.2	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.1	GO:0016212	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.2	GO:0034450	ubiquitin-ubiquitin ligase activity(GO:0034450)
0.0	0.4	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.1	GO:0004908	interleukin-1 receptor activity(GO:0004908)
0.0	0.1	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.1	GO:0070996	type 1 melanocortin receptor binding(GO:0070996)
0.0	0.1	GO:0004924	oncostatin-M receptor activity(GO:0004924)
0.0	0.1	GO:0004887	thyroid hormone receptor activity(GO:0004887)
0.0	0.1	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.0	0.1	GO:0051718	DNA (cytosine-5-)-methyltransferase activity(GO:0003886) DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates(GO:0051718)
0.0	0.2	GO:0008301	DNA binding, bending(GO:0008301)
0.0	0.1	GO:0051525	NFAT protein binding(GO:0051525)
0.0	0.0	GO:0004611	phosphoenolpyruvate carboxykinase activity(GO:0004611)
0.0	0.0	GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
0.0	0.0	GO:0035877	death effector domain binding(GO:0035877)
0.0	0.1	GO:0000150	recombinase activity(GO:0000150)
0.0	0.1	GO:0001758	retinal dehydrogenase activity(GO:0001758)
0.0	0.1	GO:0031750	D3 dopamine receptor binding(GO:0031750)
0.0	0.1	GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.0	0.0	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.1	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.0	GO:0043533	inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533)
0.0	0.1	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.0	0.2	GO:0004787	thiamine-pyrophosphatase activity(GO:0004787) UDP-2,3-diacylglucosamine hydrolase activity(GO:0008758) dATP pyrophosphohydrolase activity(GO:0008828) dihydroneopterin monophosphate phosphatase activity(GO:0019176) dihydroneopterin triphosphate pyrophosphohydrolase activity(GO:0019177) dTTP diphosphatase activity(GO:0036218) phosphocholine hydrolase activity(GO:0044606)
0.0	0.1	GO:0015288	porin activity(GO:0015288)
0.0	0.0	GO:1904288	BAT3 complex binding(GO:1904288)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0000900	translation repressor activity, nucleic acid binding(GO:0000900)
0.0	0.1	GO:0015280	ligand-gated sodium channel activity(GO:0015280)
0.0	0.1	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.0	GO:0009374	biotin binding(GO:0009374)
0.0	0.0	GO:1990430	extracellular matrix protein binding(GO:1990430)
0.0	0.1	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.0	0.0	GO:0030160	GKAP/Homer scaffold activity(GO:0030160)
0.0	0.1	GO:0004784	superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.0	0.5	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.0	0.0	GO:0001069	regulatory region RNA binding(GO:0001069)
0.0	0.0	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.1	GO:0015037	peptide disulfide oxidoreductase activity(GO:0015037)
0.0	0.1	GO:0001013	RNA polymerase I regulatory region DNA binding(GO:0001013)
0.0	0.1	GO:1990226	histone methyltransferase binding(GO:1990226)
0.0	0.0	GO:0016854	racemase and epimerase activity(GO:0016854)
0.0	0.1	GO:0044548	S100 protein binding(GO:0044548)
0.0	0.1	GO:0017070	U6 snRNA binding(GO:0017070)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.0	GO:0031697	beta-1 adrenergic receptor binding(GO:0031697)
0.0	0.1	GO:0043539	protein serine/threonine kinase activator activity(GO:0043539)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.4	PID IGF1 PATHWAY	IGF1 pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION	Genes involved in Influenza Viral RNA Transcription and Replication
0.0	REACTOME DESTABILIZATION OF MRNA BY KSRP	Genes involved in Destabilization of mRNA by KSRP
0.1	REACTOME G2 M DNA DAMAGE CHECKPOINT	Genes involved in G2/M DNA damage checkpoint
0.1	REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR	Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.5	REACTOME TRIGLYCERIDE BIOSYNTHESIS	Genes involved in Triglyceride Biosynthesis
0.1	REACTOME SIGNALING BY FGFR3 MUTANTS	Genes involved in Signaling by FGFR3 mutants
0.1	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.2	REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR	Genes involved in Signaling by constitutively active EGFR
0.2	REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY	Genes involved in Post-chaperonin tubulin folding pathway
0.2	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.0	REACTOME BILE ACID AND BILE SALT METABOLISM	Genes involved in Bile acid and bile salt metabolism