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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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CREMA is a free online tool that recognizes most important transcription factors that change the chromatin state across different samples.

Results for Pax6

Z-value: 0.81

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Transcription factors associated with Pax6

Gene Symbol	Gene ID	Gene Info
Pax6 Ensembl NCBI MGI UniProt	ENSMUSG00000027168.15	Pax6

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Gene	Promoter	Distance	Association probability	Pearson corr. coef.	P-value	Plot
Pax6	chr2_105675376_105675546	28	0.972119	0.37	4.7e-01	Click!
Pax6	chr2_105673831_105674008	44	0.969838	-0.19	7.1e-01	Click!
Pax6	chr2_105687448_105687763	2283	0.259778	-0.10	8.6e-01	Click!
Pax6	chr2_105674236_105674387	348	0.850363	-0.03	9.5e-01	Click!

Activity of the Pax6 motif across conditions

Conditions sorted by the z-value of the Pax6 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr1_74331641_74331792	0.51	Pnkd	paroxysmal nonkinesiogenic dyskinesia	894	0.38
chr4_34495112_34495276	0.46	Gm12350	predicted gene 12350	9362	0.19
chr5_122263936_122264091	0.44	Tctn1	tectonic family member 1	402	0.76
chr12_21183267_21183628	0.44	AC156032.1		63876	0.08
chr1_180161827_180161978	0.41	Cdc42bpa	CDC42 binding protein kinase alpha	895	0.53
chr9_65333970_65334121	0.40	Gm39363	predicted gene, 39363	1525	0.2
chr9_53772188_53772357	0.39	Slc35f2	solute carrier family 35, member F2	734	0.65
chr15_58701542_58701739	0.39	Fer1l6	fer-1-like 6 (C. elegans)	53135	0.12
chr10_96235051_96235242	0.38	4930459C07Rik	RIKEN cDNA 4930459C07 gene	8939	0.2
chr17_45322913_45323086	0.36	Cdc5l	cell division cycle 5-like (S. pombe)	92685	0.06
chr15_67062566_67062733	0.34	Gm31342	predicted gene, 31342	22591	0.2
chr13_30235169_30235331	0.34	Mboat1	membrane bound O-acyltransferase domain containing 1	3397	0.27
chr17_30609874_30610226	0.32	Glo1	glyoxalase 1	2519	0.15
chr19_38356216_38356572	0.31	Gm50150	predicted gene, 50150	13780	0.14
chr2_129380377_129380528	0.31	Spcs2-ps	signal peptidase complex subunit 2, pseudogene	1056	0.39
chr8_45295376_45295693	0.30	Klkb1	kallikrein B, plasma 1	675	0.64
chr8_10939586_10939983	0.30	Gm44955	predicted gene 44955	8106	0.11
chr19_34518293_34518456	0.30	Lipa	lysosomal acid lipase A	7394	0.14
chr9_95571722_95572131	0.30	Paqr9	progestin and adipoQ receptor family member IX	12269	0.13
chr18_53135544_53135717	0.30	Snx2	sorting nexin 2	40686	0.18
chr19_21824245_21824555	0.30	Gm50130	predicted gene, 50130	9356	0.22
chr10_84055045_84055203	0.30	Gm37908	predicted gene, 37908	6634	0.2
chr2_79254721_79254886	0.29	Itga4	integrin alpha 4	623	0.79
chr6_121870418_121870617	0.28	Mug1	murinoglobulin 1	15060	0.19
chr11_97884607_97884760	0.28	Gm11630	predicted gene 11630	89	0.87
chr5_120125413_120125579	0.28	Rbm19	RNA binding motif protein 19	6900	0.2
chr12_25092894_25093391	0.28	Id2	inhibitor of DNA binding 2	2945	0.22
chr7_130716830_130716981	0.28	Tacc2	transforming, acidic coiled-coil containing protein 2	3228	0.24
chr6_90763367_90763528	0.27	Iqsec1	IQ motif and Sec7 domain 1	694	0.67
chr12_80136272_80136487	0.26	2310015A10Rik	RIKEN cDNA 2310015A10 gene	3535	0.16
chr12_102683391_102683709	0.24	Mir1936	microRNA 1936	1470	0.28
chr9_63613110_63613389	0.24	Aagab	alpha- and gamma-adaptin binding protein	3739	0.23
chr15_89475186_89475337	0.24	Arsa	arylsulfatase A	852	0.31
chr4_15091382_15091540	0.24	Necab1	N-terminal EF-hand calcium binding protein 1	57500	0.12
chr4_129795439_129795602	0.24	Ptp4a2	protein tyrosine phosphatase 4a2	15699	0.12
chr5_127633759_127633922	0.23	Slc15a4	solute carrier family 15, member 4	943	0.47
chr1_136142886_136143042	0.22	Kif21b	kinesin family member 21B	11510	0.11
chr6_60600291_60600442	0.22	Gm35386	predicted gene, 35386	13588	0.26
chr11_51833074_51833257	0.22	Jade2	jade family PHD finger 2	23960	0.15
chr13_95952461_95952612	0.22	Sv2c	synaptic vesicle glycoprotein 2c	32314	0.16
chr1_133825700_133825858	0.22	Gm10537	predicted gene 10537	3749	0.17
chrX_48193537_48193988	0.22	Zdhhc9	zinc finger, DHHC domain containing 9	14566	0.16
chr2_114835914_114836098	0.22	Gm13974	predicted gene 13974	18087	0.25
chr5_112292069_112292220	0.22	Tpst2	protein-tyrosine sulfotransferase 2	3382	0.15
chr2_84184780_84185142	0.22	Gm25972	predicted gene, 25972	34906	0.15
chr3_83002849_83003457	0.22	Fgg	fibrinogen gamma chain	4571	0.17
chr5_52975314_52975474	0.22	Gm30301	predicted gene, 30301	6643	0.16
chr1_184290067_184290274	0.22	Gm37223	predicted gene, 37223	68159	0.11
chr3_137864426_137864597	0.21	H2az1	H2A.Z variant histone 1	24	0.62
chr16_16224499_16224674	0.21	Pkp2	plakophilin 2	11268	0.19
chr5_100872116_100872267	0.21	Gm42987	predicted gene 42987	11942	0.11
chr1_180813964_180814133	0.21	H3f3a	H3.3 histone A	105	0.7
chr9_95573382_95573533	0.21	Paqr9	progestin and adipoQ receptor family member IX	13800	0.12
chr15_62205085_62205531	0.21	Pvt1	Pvt1 oncogene	12915	0.24
chr11_30792834_30792985	0.20	Psme4	proteasome (prosome, macropain) activator subunit 4	18628	0.14
chr10_19991939_19992101	0.20	Map3k5	mitogen-activated protein kinase kinase kinase 5	40965	0.16
chr16_16225035_16225410	0.20	Pkp2	plakophilin 2	11904	0.19
chr18_46716574_46716962	0.20	Cdo1	cysteine dioxygenase 1, cytosolic	11261	0.13
chr6_94549050_94549217	0.20	Slc25a26	solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 26	14993	0.2
chr13_36459438_36459830	0.20	Gm48763	predicted gene, 48763	354	0.9
chr14_17894891_17895062	0.20	Thrb	thyroid hormone receptor beta	67845	0.12
chr10_127289815_127290011	0.20	Gm4189	predicted gene 4189	811	0.21
chr12_83375040_83375279	0.20	Dpf3	D4, zinc and double PHD fingers, family 3	24264	0.22
chr2_167574964_167575153	0.19	Gm11475	predicted gene 11475	16337	0.11
chr2_152792514_152792820	0.19	Gm23802	predicted gene, 23802	19778	0.11
chr1_172312301_172312452	0.19	Igsf8	immunoglobulin superfamily, member 8	9	0.96
chr19_47511131_47511282	0.19	Gm19557	predicted gene, 19557	1776	0.29
chr12_12320785_12320940	0.19	Fam49a	family with sequence similarity 49, member A	58673	0.14
chr19_12634142_12634556	0.19	Glyat	glycine-N-acyltransferase	816	0.44
chr12_75694445_75694598	0.19	Wdr89	WD repeat domain 89	24984	0.18
chr5_8849350_8849972	0.19	Abcb1b	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	328	0.86
chr2_163480327_163480478	0.19	Fitm2	fat storage-inducing transmembrane protein 2	7773	0.11
chr10_118737027_118737347	0.19	Gm47425	predicted gene, 47425	17759	0.17
chr7_25623384_25623543	0.18	Dmac2	distal membrane arm assembly complex 2	2560	0.12
chr7_130789536_130789700	0.18	Btbd16	BTB (POZ) domain containing 16	15451	0.14
chr9_63201496_63201967	0.18	Skor1	SKI family transcriptional corepressor 1	52770	0.12
chr4_33243089_33243244	0.18	Pnrc1	proline-rich nuclear receptor coactivator 1	4409	0.19
chr19_41346470_41346772	0.18	Pik3ap1	phosphoinositide-3-kinase adaptor protein 1	38475	0.17
chr1_182609752_182609909	0.18	Capn8	calpain 8	44792	0.12
chr1_86394431_86394582	0.18	Nmur1	neuromedin U receptor 1	3684	0.12
chr15_99724752_99724954	0.18	Gm16537	predicted gene 16537	379	0.58
chr4_150334328_150334517	0.18	Gm23209	predicted gene, 23209	13229	0.17
chr17_13408343_13408512	0.18	Gm8597	predicted gene 8597	4236	0.13
chr9_64049525_64049685	0.18	Gm25606	predicted gene, 25606	1109	0.4
chr2_158225371_158225751	0.18	D630003M21Rik	RIKEN cDNA D630003M21 gene	3661	0.17
chr2_119355713_119355881	0.17	Chac1	ChaC, cation transport regulator 1	4568	0.16
chr13_32828221_32828372	0.17	Wrnip1	Werner helicase interacting protein 1	7530	0.14
chr6_124901137_124901288	0.17	Lag3	lymphocyte-activation gene 3	8839	0.07
chr17_84896467_84896802	0.17	Gm49982	predicted gene, 49982	5935	0.19
chr16_24223468_24223662	0.17	Gm31814	predicted gene, 31814	7041	0.23
chr1_58718073_58718224	0.17	Cflar	CASP8 and FADD-like apoptosis regulator	4262	0.15
chr10_71328527_71328693	0.17	Rpl19-ps2	ribosomal protein L19, pseudogene 2	9844	0.12
chr19_36796940_36797118	0.17	Gm50112	predicted gene, 50112	21619	0.18
chr10_77051818_77052096	0.17	Col18a1	collagen, type XVIII, alpha 1	8040	0.14
chr8_93333023_93333204	0.17	Ces1g	carboxylesterase 1G	4195	0.17
chr4_104822600_104822778	0.17	C8b	complement component 8, beta polypeptide	23481	0.18
chr11_58884795_58884971	0.17	Gm12256	predicted gene 12256	4827	0.08
chr12_82397673_82398162	0.17	Sipa1l1	signal-induced proliferation-associated 1 like 1	22698	0.24
chr5_115528254_115528453	0.17	Pxn	paxillin	8048	0.09
chr1_62425224_62425405	0.17	Pard3bos3	par-3 family cell polarity regulator beta, opposite strand 3	73947	0.11
chr6_128519043_128519655	0.17	Pzp	PZP, alpha-2-macroglobulin like	7354	0.09
chr12_69215107_69215258	0.16	Pole2	polymerase (DNA directed), epsilon 2 (p59 subunit)	1281	0.21
chr1_179961858_179962048	0.16	Cdc42bpa	CDC42 binding protein kinase alpha	843	0.65
chr13_93618437_93618616	0.16	Gm15622	predicted gene 15622	6856	0.17
chr19_42562288_42562441	0.16	Gm16541	predicted gene 16541	731	0.61
chr2_68001837_68002008	0.16	Gm13607	predicted gene 13607	79869	0.09
chr5_102511749_102511901	0.16	1700013M08Rik	RIKEN cDNA 1700013M08 gene	28536	0.2
chr6_108507437_108507634	0.16	Itpr1	inositol 1,4,5-trisphosphate receptor 1	778	0.59
chr2_90474865_90475228	0.16	Ptprj	protein tyrosine phosphatase, receptor type, J	3710	0.21
chr4_35134987_35135178	0.16	Ifnk	interferon kappa	16974	0.18
chr1_88630811_88630966	0.16	Gm38130	predicted gene, 38130	22197	0.15
chr5_65350576_65350727	0.16	Klb	klotho beta	2243	0.19
chr2_35215153_35215312	0.16	Gm13605	predicted gene 13605	9301	0.15
chr14_122464092_122464278	0.16	Zic5	zinc finger protein of the cerebellum 5	1492	0.27
chr17_80479277_80479673	0.16	Sos1	SOS Ras/Rac guanine nucleotide exchange factor 1	494	0.83
chr4_57954096_57954315	0.16	Txn1	thioredoxin 1	2206	0.32
chr14_18221191_18221360	0.16	Nr1d2	nuclear receptor subfamily 1, group D, member 2	8903	0.14
chr14_21096961_21097138	0.16	Adk	adenosine kinase	20897	0.2
chr6_48569197_48569793	0.16	Rarres2	retinoic acid receptor responder (tazarotene induced) 2	3151	0.09
chr3_88102838_88102989	0.15	Iqgap3	IQ motif containing GTPase activating protein 3	2229	0.18
chr8_72665741_72665896	0.15	Nwd1	NACHT and WD repeat domain containing 1	8732	0.15
chr11_106579550_106579738	0.15	Tex2	testis expressed gene 2	531	0.78
chr12_25416673_25416856	0.15	Gm36723	predicted gene, 36723	22009	0.24
chr5_21053272_21053655	0.15	Ptpn12	protein tyrosine phosphatase, non-receptor type 12	2262	0.26
chr5_36678947_36679110	0.15	Gm25767	predicted gene, 25767	7370	0.14
chr14_20208430_20208743	0.15	Gm48395	predicted gene, 48395	6916	0.12
chr1_106200351_106200637	0.15	Gm38235	predicted gene, 38235	18820	0.17
chr2_29739509_29739665	0.15	Gm9823	predicted gene 9823	922	0.43
chr9_65831812_65832370	0.15	n-R5s85	nuclear encoded rRNA 5S 85	4262	0.15
chr7_46827705_46827889	0.15	Gm45308	predicted gene 45308	4667	0.1
chr3_108011690_108011861	0.15	Gstm1	glutathione S-transferase, mu 1	1541	0.17
chr6_141944108_141944325	0.15	Slco1a1	solute carrier organic anion transporter family, member 1a1	2594	0.32
chr11_49085302_49085517	0.15	Ifi47	interferon gamma inducible protein 47	1291	0.22
chr11_84959738_84959922	0.15	Car4	carbonic anhydrase 4	1726	0.3
chr7_49233095_49233247	0.15	Nav2	neuron navigator 2	13018	0.21
chr11_120280389_120280554	0.15	Gm47297	predicted gene, 47297	5984	0.11
chr13_54566023_54566188	0.15	4833439L19Rik	RIKEN cDNA 4833439L19 gene	670	0.53
chr2_153600154_153600312	0.15	Commd7	COMM domain containing 7	32498	0.13
chr17_29486635_29486945	0.15	Pim1	proviral integration site 1	3963	0.13
chr19_7090027_7090210	0.15	AC109619.1	novel transcript, antisense to Macrod1	1697	0.24
chr3_38259341_38259510	0.15	Gm2965	predicted gene 2965	35974	0.16
chr13_23730927_23731223	0.14	Gm11338	predicted gene 11338	2527	0.07
chr2_73455695_73455846	0.14	Wipf1	WAS/WASL interacting protein family, member 1	1791	0.28
chr12_80113015_80113206	0.14	Zfp36l1	zinc finger protein 36, C3H type-like 1	97	0.95
chr4_137747156_137747355	0.14	Alpl	alkaline phosphatase, liver/bone/kidney	108	0.97
chr17_31386878_31387227	0.14	Pde9a	phosphodiesterase 9A	758	0.59
chr16_92433602_92433820	0.14	Gm46555	predicted gene, 46555	23766	0.12
chr12_113255450_113255616	0.14	Gm25622	predicted gene, 25622	41384	0.09
chr2_164769333_164769540	0.14	Gm11457	predicted gene 11457	183	0.71
chr13_39657075_39657270	0.14	Gm47352	predicted gene, 47352	7661	0.21
chr18_75821165_75821446	0.14	Zbtb7c	zinc finger and BTB domain containing 7C	1090	0.57
chr15_67345700_67345857	0.14	1700012I11Rik	RIKEN cDNA 1700012I11 gene	119009	0.06
chr5_93250297_93250457	0.14	Ccng2	cyclin G2	16880	0.14
chr5_64344454_64344620	0.14	Gm43838	predicted gene 43838	15977	0.14
chr4_70410468_70410632	0.14	Cdk5rap2	CDK5 regulatory subunit associated protein 2	107	0.98
chr16_24090719_24090960	0.14	Gm31583	predicted gene, 31583	750	0.64
chr2_84386945_84387393	0.14	Calcrl	calcitonin receptor-like	11811	0.2
chr4_57295426_57295990	0.14	Gm12536	predicted gene 12536	4388	0.21
chr10_8873465_8873676	0.14	Gm26674	predicted gene, 26674	11067	0.15
chr11_53783385_53783552	0.14	Gm17334	predicted gene, 17334	10273	0.11
chr12_79561056_79561219	0.14	Rad51b	RAD51 paralog B	233784	0.02
chr15_76232589_76232802	0.14	Plec	plectin	121	0.87
chr19_4698221_4698442	0.14	Gm960	predicted gene 960	16	0.96
chr15_28057589_28057753	0.14	Gm19883	predicted gene, 19883	16662	0.18
chr6_5509839_5510005	0.14	Pdk4	pyruvate dehydrogenase kinase, isoenzyme 4	13613	0.28
chr5_140852570_140852762	0.14	Gna12	guanine nucleotide binding protein, alpha 12	22235	0.18
chr13_114659678_114659829	0.14	4930544M13Rik	RIKEN cDNA 4930544M13 gene	52516	0.13
chr18_54970945_54971399	0.14	Zfp608	zinc finger protein 608	14415	0.2
chr11_23954708_23954885	0.13	Gm12062	predicted gene 12062	25942	0.16
chr3_157748470_157748625	0.13	Gm33466	predicted gene, 33466	22139	0.2
chr5_53046104_53046266	0.13	Gm17182	predicted gene 17182	3003	0.21
chr19_21737626_21737804	0.13	Gm50129	predicted gene, 50129	8445	0.21
chr6_104028580_104028747	0.13	Gm21054	predicted gene, 21054	64024	0.15
chr5_117191658_117191809	0.13	n-R5s174	nuclear encoded rRNA 5S 174	4822	0.17
chr6_128497203_128497354	0.13	Pzp	PZP, alpha-2-macroglobulin like	2055	0.17
chr3_89280151_89280307	0.13	Efna1	ephrin A1	584	0.47
chr9_85248224_85248375	0.13	Gm48831	predicted gene, 48831	8258	0.19
chr8_85032460_85032611	0.13	Tnpo2	transportin 2 (importin 3, karyopherin beta 2b)	4380	0.07
chr6_116264926_116265157	0.13	Zfand4	zinc finger, AN1-type domain 4	776	0.4
chr11_62487650_62487823	0.13	Gm12278	predicted gene 12278	4939	0.13
chr12_108651085_108651241	0.13	Mir342	microRNA 342	7457	0.15
chr5_63936466_63936784	0.13	Rell1	RELT-like 1	5711	0.18
chr3_132863960_132864140	0.13	Gm29811	predicted gene, 29811	14546	0.14
chr16_4029500_4029663	0.13	Dnase1	deoxyribonuclease I	7361	0.1
chr8_110941639_110941803	0.13	St3gal2	ST3 beta-galactoside alpha-2,3-sialyltransferase 2	817	0.47
chr5_134639466_134639692	0.13	Eif4h	eukaryotic translation initiation factor 4H	89	0.95
chr4_99102964_99103128	0.13	Gm12852	predicted gene 12852	732	0.62
chr10_10472367_10472528	0.13	Adgb	androglobin	121	0.97
chr16_30060579_30060767	0.13	Hes1	hes family bHLH transcription factor 1	3711	0.19
chr1_93124444_93124635	0.13	Gm28086	predicted gene 28086	436	0.76
chr5_107837254_107837906	0.13	Evi5	ecotropic viral integration site 5	100	0.94
chr14_20345992_20346164	0.13	Ecd	ecdysoneless cell cycle regulator	1972	0.19
chr9_51994808_51995091	0.13	Gm6981	predicted pseudogene 6981	8332	0.18
chr1_4857561_4857736	0.13	Tcea1	transcription elongation factor A (SII) 1	166	0.93
chr10_24948485_24948668	0.12	Gm36172	predicted gene, 36172	20957	0.13
chr8_11486156_11486314	0.12	Rab20	RAB20, member RAS oncogene family	7525	0.12
chrX_129949506_129949684	0.12	Diaph2	diaphanous related formin 2	22938	0.28
chr13_45637816_45638014	0.12	Gmpr	guanosine monophosphate reductase	91762	0.08
chr1_86479051_86479408	0.12	Rpl30-ps6	ribosomal protein L30, pseudogene 6	5570	0.15
chr7_44749310_44749461	0.12	Vrk3	vaccinia related kinase 3	442	0.55

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.3	GO:1904491	protein localization to ciliary transition zone(GO:1904491)
0.1	0.4	GO:0060710	chorio-allantoic fusion(GO:0060710)
0.1	0.2	GO:0051919	positive regulation of fibrinolysis(GO:0051919)
0.1	0.2	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
0.0	0.2	GO:0051596	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
0.0	0.2	GO:0014045	establishment of endothelial blood-brain barrier(GO:0014045)
0.0	0.1	GO:0007296	vitellogenesis(GO:0007296)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:0042138	meiotic DNA double-strand break formation(GO:0042138)
0.0	0.3	GO:0007097	nuclear migration(GO:0007097)
0.0	0.1	GO:0019448	cysteine catabolic process(GO:0009093) L-cysteine catabolic process(GO:0019448) L-cysteine metabolic process(GO:0046439)
0.0	0.1	GO:0048769	sarcomerogenesis(GO:0048769)
0.0	0.1	GO:0006203	dGTP catabolic process(GO:0006203)
0.0	0.1	GO:0031581	hemidesmosome assembly(GO:0031581)
0.0	0.1	GO:0045897	regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897)
0.0	0.1	GO:0003149	membranous septum morphogenesis(GO:0003149)
0.0	0.1	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:0036066	protein O-linked fucosylation(GO:0036066)
0.0	0.1	GO:0010694	positive regulation of alkaline phosphatase activity(GO:0010694)
0.0	0.1	GO:0043152	induction of bacterial agglutination(GO:0043152)
0.0	0.1	GO:0007084	mitotic nuclear envelope reassembly(GO:0007084)
0.0	0.1	GO:0070973	protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0	0.0	GO:0097360	chorionic trophoblast cell proliferation(GO:0097360) regulation of chorionic trophoblast cell proliferation(GO:1901382)
0.0	0.1	GO:0072429	response to intra-S DNA damage checkpoint signaling(GO:0072429)
0.0	0.1	GO:0010735	positive regulation of transcription via serum response element binding(GO:0010735)
0.0	0.1	GO:0001831	trophectodermal cellular morphogenesis(GO:0001831)
0.0	0.0	GO:0060066	oviduct development(GO:0060066)
0.0	0.1	GO:0042167	heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.0	0.1	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0	0.0	GO:1990791	dorsal root ganglion development(GO:1990791)
0.0	0.2	GO:1903025	regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903025)
0.0	0.1	GO:0043985	histone H4-R3 methylation(GO:0043985)
0.0	0.1	GO:0034140	negative regulation of toll-like receptor 3 signaling pathway(GO:0034140)
0.0	0.1	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.1	GO:2000774	positive regulation of cellular senescence(GO:2000774)
0.0	0.1	GO:0090219	negative regulation of lipid kinase activity(GO:0090219)
0.0	0.0	GO:0021564	vagus nerve development(GO:0021564)
0.0	0.2	GO:0001731	formation of translation preinitiation complex(GO:0001731)
0.0	0.1	GO:1903977	positive regulation of glial cell migration(GO:1903977)
0.0	0.0	GO:0070375	ERK5 cascade(GO:0070375)
0.0	0.0	GO:0033668	negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
0.0	0.1	GO:0015722	canalicular bile acid transport(GO:0015722)
0.0	0.0	GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway(GO:0060397)
0.0	0.0	GO:0000379	tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.0	0.0	GO:0060916	mesenchymal cell proliferation involved in lung development(GO:0060916)
0.0	0.0	GO:0007089	traversing start control point of mitotic cell cycle(GO:0007089)
0.0	0.1	GO:0002159	desmosome assembly(GO:0002159)
0.0	0.1	GO:0061314	Notch signaling involved in heart development(GO:0061314)
0.0	0.1	GO:0090383	phagosome acidification(GO:0090383)
0.0	0.1	GO:0006659	phosphatidylserine biosynthetic process(GO:0006659)
0.0	0.0	GO:0070164	negative regulation of adiponectin secretion(GO:0070164)
0.0	0.0	GO:0006344	maintenance of chromatin silencing(GO:0006344)
0.0	0.1	GO:0072502	cellular phosphate ion homeostasis(GO:0030643) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0	0.0	GO:0042360	vitamin E metabolic process(GO:0042360)
0.0	0.0	GO:0051182	coenzyme transport(GO:0051182)
0.0	0.0	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.2	GO:0090231	regulation of spindle checkpoint(GO:0090231)
0.0	0.0	GO:0010510	regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510)
0.0	0.1	GO:0003199	endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199)
0.0	0.2	GO:0032011	ARF protein signal transduction(GO:0032011) regulation of ARF protein signal transduction(GO:0032012)
0.0	0.1	GO:0071361	cellular response to ethanol(GO:0071361)
0.0	0.1	GO:0071494	cellular response to UV-C(GO:0071494)
0.0	0.1	GO:0086023	adrenergic receptor signaling pathway involved in heart process(GO:0086023)
0.0	0.1	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.1	GO:0042270	protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.0	0.1	GO:0006398	mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.0	0.0	GO:0051410	detoxification of nitrogen compound(GO:0051410) cellular detoxification of nitrogen compound(GO:0070458)
0.0	0.0	GO:1990034	calcium ion export from cell(GO:1990034)
0.0	0.1	GO:0006104	succinyl-CoA metabolic process(GO:0006104)
0.0	0.0	GO:0036493	positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.0	0.0	GO:1901529	positive regulation of anion channel activity(GO:1901529)
0.0	0.1	GO:0030953	astral microtubule organization(GO:0030953)
0.0	0.0	GO:0006166	purine ribonucleoside salvage(GO:0006166)

Gene overrepresentation in cellular component category:

Total log-likelihood	Term	Description
0.2	GO:0000805	X chromosome(GO:0000805)
0.2	GO:0030056	hemidesmosome(GO:0030056)
0.3	GO:0036038	MKS complex(GO:0036038)
0.1	GO:0016281	eukaryotic translation initiation factor 4F complex(GO:0016281)
0.1	GO:0046691	intracellular canaliculus(GO:0046691)
0.0	GO:0032127	dense core granule membrane(GO:0032127)
0.1	GO:1990604	IRE1-TRAF2-ASK1 complex(GO:1990604)
0.0	GO:0032937	SREBP-SCAP-Insig complex(GO:0032937)
0.0	GO:0005610	laminin-5 complex(GO:0005610)
0.1	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
0.1	GO:0005577	fibrinogen complex(GO:0005577)
0.1	GO:0071256	Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
0.0	GO:0036488	CHOP-C/EBP complex(GO:0036488)
0.1	GO:0000127	transcription factor TFIIIC complex(GO:0000127)
0.1	GO:0046581	intercellular canaliculus(GO:0046581)
0.1	GO:0005663	DNA replication factor C complex(GO:0005663)
0.2	GO:0097431	mitotic spindle pole(GO:0097431)
0.0	GO:0030127	COPII vesicle coat(GO:0030127)
0.1	GO:0065010	extracellular membrane-bounded organelle(GO:0065010)
0.0	GO:0031265	CD95 death-inducing signaling complex(GO:0031265)
0.1	GO:0048476	Holliday junction resolvase complex(GO:0048476)
0.1	GO:0031232	extrinsic component of external side of plasma membrane(GO:0031232)
0.0	GO:0097651	phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0	GO:0000214	tRNA-intron endonuclease complex(GO:0000214)
0.3	GO:0008305	integrin complex(GO:0008305)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	0.2	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
0.0	0.2	GO:0019960	C-X3-C chemokine binding(GO:0019960)
0.0	0.1	GO:0047961	glycine N-acyltransferase activity(GO:0047961)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0031752	D5 dopamine receptor binding(GO:0031752)
0.0	0.1	GO:0033592	RNA strand annealing activity(GO:0033592)
0.0	0.2	GO:0008559	xenobiotic-transporting ATPase activity(GO:0008559)
0.0	0.1	GO:0004687	myosin light chain kinase activity(GO:0004687)
0.0	0.1	GO:0005290	L-histidine transmembrane transporter activity(GO:0005290)
0.0	0.1	GO:0003918	DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.0	0.1	GO:0016823	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:1990460	leptin receptor binding(GO:1990460)
0.0	0.1	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.0	GO:0036137	kynurenine-oxoglutarate transaminase activity(GO:0016212) kynurenine aminotransferase activity(GO:0036137)
0.0	0.1	GO:0038132	neuregulin binding(GO:0038132)
0.0	0.1	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
0.0	0.0	GO:0004699	calcium-independent protein kinase C activity(GO:0004699)
0.0	0.1	GO:0016846	carbon-sulfur lyase activity(GO:0016846)
0.0	0.1	GO:0051434	BH3 domain binding(GO:0051434)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.0	GO:0047756	chondroitin 4-sulfotransferase activity(GO:0047756)
0.0	0.1	GO:0034823	3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity(GO:0010435) 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity(GO:0018854) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity(GO:0018855) benzoyl acetate-CoA ligase activity(GO:0018856) 2,4-dichlorobenzoate-CoA ligase activity(GO:0018857) pivalate-CoA ligase activity(GO:0034783) cyclopropanecarboxylate-CoA ligase activity(GO:0034793) adipate-CoA ligase activity(GO:0034796) citronellyl-CoA ligase activity(GO:0034823) mentha-1,3-dione-CoA ligase activity(GO:0034841) thiophene-2-carboxylate-CoA ligase activity(GO:0034842) 2,4,4-trimethylpentanoate-CoA ligase activity(GO:0034865) cis-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034942) trans-2-methyl-5-isopropylhexa-2,5-dienoate-CoA ligase activity(GO:0034943) branched-chain acyl-CoA synthetase (ADP-forming) activity(GO:0043759) aryl-CoA synthetase (ADP-forming) activity(GO:0043762) 3-hydroxypropionyl-CoA synthetase activity(GO:0043955) perillic acid:CoA ligase (ADP-forming) activity(GO:0052685) perillic acid:CoA ligase (AMP-forming) activity(GO:0052686) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (ADP-forming) activity(GO:0052687) (3R)-3-isopropenyl-6-oxoheptanoate:CoA ligase (AMP-forming) activity(GO:0052688) pristanate-CoA ligase activity(GO:0070251) malonyl-CoA synthetase activity(GO:0090409)
0.0	0.1	GO:0090482	vitamin transmembrane transporter activity(GO:0090482)
0.0	0.0	GO:0004332	fructose-bisphosphate aldolase activity(GO:0004332)
0.0	0.0	GO:0035529	NADH pyrophosphatase activity(GO:0035529)
0.0	0.1	GO:0018637	3-(3-hydroxyphenyl)propionate hydroxylase activity(GO:0008688) 4-chlorobenzaldehyde oxidase activity(GO:0018471) 3,5-xylenol methylhydroxylase activity(GO:0018630) phenylacetate hydroxylase activity(GO:0018631) 4-nitrophenol 4-monooxygenase activity(GO:0018632) dimethyl sulfide monooxygenase activity(GO:0018633) alpha-pinene monooxygenase [NADH] activity(GO:0018634) 1-hydroxy-2-naphthoate hydroxylase activity(GO:0018637) toluene 4-monooxygenase activity(GO:0018638) xylene monooxygenase activity(GO:0018639) dibenzothiophene monooxygenase activity(GO:0018640) 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018641) chlorophenol 4-monooxygenase activity(GO:0018642) carbon disulfide oxygenase activity(GO:0018643) toluene 2-monooxygenase activity(GO:0018644) 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity(GO:0018646) phenanthrene 1,2-monooxygenase activity(GO:0018647) tetrahydrofuran hydroxylase activity(GO:0018649) styrene monooxygenase activity(GO:0018650) toluene-4-sulfonate monooxygenase activity(GO:0018651) toluene-sulfonate methyl-monooxygenase activity(GO:0018652) 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity(GO:0018653) 2-hydroxy-phenylacetate hydroxylase activity(GO:0018654) 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity(GO:0018655) phenanthrene 3,4-monooxygenase activity(GO:0018656) toluene 3-monooxygenase activity(GO:0018657) 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity(GO:0018660) limonene monooxygenase activity(GO:0019113) 2-methylnaphthalene hydroxylase activity(GO:0034526) 1-methylnaphthalene hydroxylase activity(GO:0034534) bisphenol A hydroxylase A activity(GO:0034560) salicylate 5-hydroxylase activity(GO:0034785) isobutylamine N-hydroxylase activity(GO:0034791) branched-chain dodecylbenzene sulfonate monooxygenase activity(GO:0034802) 3-HSA hydroxylase activity(GO:0034819) 4-hydroxypyridine-3-hydroxylase activity(GO:0034894) 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity(GO:0043719) 6-hydroxynicotinate 3-monooxygenase activity(GO:0043731) thalianol hydroxylase activity(GO:0080014)
0.0	0.0	GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.0	0.0	GO:0008898	S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0	0.0	GO:0019770	IgG receptor activity(GO:0019770)
0.0	0.1	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.0	GO:0000213	tRNA-intron endonuclease activity(GO:0000213)
0.0	0.0	GO:0004948	calcitonin receptor activity(GO:0004948)
0.0	0.1	GO:0070324	thyroid hormone binding(GO:0070324)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.0	0.2	PID ARF6 PATHWAY	Arf6 signaling events
0.0	0.2	PID INTEGRIN5 PATHWAY	Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Total log-likelihood	Term	Description
0.1	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.2	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.2	REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS	Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.1	REACTOME THE ACTIVATION OF ARYLSULFATASES	Genes involved in The activation of arylsulfatases
0.1	REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS	Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.0	REACTOME ACYL CHAIN REMODELLING OF PI	Genes involved in Acyl chain remodelling of PI