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ENCSR904DTN: DNase-seq of mouse liver in constant darkness

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Results for Pax8

Z-value: 1.66

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Transcription factors associated with Pax8

Gene Symbol	Gene ID	Gene Info
Pax8 Ensembl NCBI MGI UniProt	ENSMUSG00000026976.9	paired box 8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

CRE	Gene	Distance	Association probability	Pearson corr. coef.	P-value	Plot
chr2_24474146_24474302	Pax8	873	0.502829	-0.73	9.9e-02	Click!
chr2_24460542_24460763	Pax8	14445	0.126804	0.58	2.3e-01	Click!
chr2_24415026_24415177	Pax8	7981	0.142348	-0.47	3.5e-01	Click!
chr2_24479227_24479538	Pax8	3783	0.159818	-0.31	5.4e-01	Click!
chr2_24469183_24469359	Pax8	5826	0.145448	0.18	7.3e-01	Click!

Activity of the Pax8 motif across conditions

Conditions sorted by the z-value of the Pax8 motif activity

Move your cursor over a bar to see sample name and corresponding Z-value.

Top target CREs of the motif:

Cis Regulatory Element (CRE)	Target Score	Top associated gene	Gene Info	Distance of CRE to TSS	CRE/Gene association probability
chr10_95144816_95145075	1.04	Gm29684	predicted gene, 29684	880	0.54
chr10_111216225_111216427	0.93	Osbpl8	oxysterol binding protein-like 8	17303	0.16
chr9_74886495_74886646	0.92	Onecut1	one cut domain, family member 1	20086	0.14
chr11_16862611_16863177	0.90	Egfr	epidermal growth factor receptor	15256	0.19
chr9_106232444_106232608	0.86	Alas1	aminolevulinic acid synthase 1	4558	0.11
chr2_58773576_58773851	0.74	Upp2	uridine phosphorylase 2	8388	0.21
chr6_136954641_136954792	0.73	Pde6h	phosphodiesterase 6H, cGMP-specific, cone, gamma	183	0.93
chr19_40165502_40165757	0.72	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	21657	0.14
chr13_63665698_63665976	0.67	Gm47387	predicted gene, 47387	4040	0.18
chr4_76942367_76942518	0.65	Gm11246	predicted gene 11246	15131	0.21
chrX_85734642_85734808	0.63	Gk	glycerol kinase	2885	0.21
chr19_40168031_40168182	0.61	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	19180	0.15
chr8_76541013_76541167	0.60	Gm27355	predicted gene, 27355	78192	0.1
chr11_16874000_16874630	0.60	Egfr	epidermal growth factor receptor	3835	0.25
chr11_94239763_94239948	0.59	Wfikkn2	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2	2852	0.23
chr5_114528485_114528658	0.57	Gm13790	predicted gene 13790	22718	0.14
chr2_8124301_8124468	0.57	Gm13254	predicted gene 13254	23481	0.29
chr10_80239863_80240052	0.53	Pwwp3a	PWWP domain containing 3A, DNA repair factor	1581	0.18
chr12_103947018_103947616	0.53	Serpina1e	serine (or cysteine) peptidase inhibitor, clade A, member 1E	9581	0.11
chr3_63296372_63296537	0.52	Mme	membrane metallo endopeptidase	359	0.92
chr8_84723608_84723805	0.51	G430095P16Rik	RIKEN cDNA G430095P16 gene	699	0.52
chr13_46154168_46154319	0.51	Gm10113	predicted gene 10113	36803	0.19
chr19_44398143_44398357	0.50	Scd1	stearoyl-Coenzyme A desaturase 1	8440	0.15
chr4_104908553_104908715	0.50	Fyb2	FYN binding protein 2	4822	0.23
chr1_50806813_50807031	0.50	Gm28321	predicted gene 28321	8453	0.28
chr4_107999051_107999218	0.50	Slc1a7	solute carrier family 1 (glutamate transporter), member 7	10883	0.13
chr1_23290878_23291029	0.49	Gm27028	predicted gene, 27028	584	0.46
chr5_125482875_125483080	0.49	Gm27551	predicted gene, 27551	3600	0.16
chr3_129450558_129450716	0.49	Rpl7a-ps7	ribosomal protein L7A, pseudogene 7	11335	0.17
chr8_66494561_66494830	0.49	Gm32568	predicted gene, 32568	364	0.85
chr8_61436826_61436991	0.49	Cbr4	carbonyl reductase 4	50826	0.12
chr9_106231818_106232229	0.48	Alas1	aminolevulinic acid synthase 1	5061	0.11
chr13_58962693_58962856	0.48	Ntrk2	neurotrophic tyrosine kinase, receptor, type 2	91039	0.06
chrX_142506860_142507020	0.48	Gm25915	predicted gene, 25915	21493	0.16
chr11_16894023_16894174	0.47	Egfr	epidermal growth factor receptor	11087	0.19
chr1_21245041_21245248	0.47	Gsta3	glutathione S-transferase, alpha 3	4515	0.13
chr5_43310353_43310569	0.46	Gm43020	predicted gene 43020	44798	0.11
chr5_148631104_148631264	0.46	Gm29815	predicted gene, 29815	17540	0.19
chr14_120256809_120256970	0.45	Mbnl2	muscleblind like splicing factor 2	18780	0.23
chr18_8864151_8864321	0.45	Gm37148	predicted gene, 37148	63999	0.13
chr18_7657709_7657860	0.45	Mpp7	membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)	30918	0.17
chr16_11164937_11165106	0.45	Gm24145	predicted gene, 24145	2246	0.15
chr2_134828255_134828422	0.45	Gm14036	predicted gene 14036	24389	0.2
chr15_83452182_83452447	0.44	Pacsin2	protein kinase C and casein kinase substrate in neurons 2	12238	0.15
chr14_63172567_63172724	0.44	Fdft1	farnesyl diphosphate farnesyl transferase 1	5148	0.16
chr9_74894770_74895613	0.43	Onecut1	one cut domain, family member 1	28707	0.13
chr15_3428785_3428957	0.43	Ghr	growth hormone receptor	42773	0.18
chr12_104343910_104344587	0.43	Serpina3k	serine (or cysteine) peptidase inhibitor, clade A, member 3K	5762	0.12
chr1_87764160_87764454	0.42	Atg16l1	autophagy related 16-like 1 (S. cerevisiae)	2594	0.19
chr11_16862337_16862489	0.42	Egfr	epidermal growth factor receptor	15737	0.19
chr1_21250942_21251436	0.42	Gsta3	glutathione S-transferase, alpha 3	2332	0.18
chr14_33058246_33058397	0.42	Wdfy4	WD repeat and FYVE domain containing 4	34984	0.17
chr7_107574186_107574390	0.42	Olfml1	olfactomedin-like 1	6522	0.16
chr14_69626858_69627238	0.41	Gm37513	predicted gene, 37513	11002	0.11
chr14_57106958_57107164	0.41	Gjb2	gap junction protein, beta 2	2359	0.23
chr10_24258031_24258221	0.41	Moxd1	monooxygenase, DBH-like 1	34581	0.16
chr4_62703366_62703517	0.41	Gm11210	predicted gene 11210	2540	0.23
chr19_21626908_21627090	0.41	1110059E24Rik	RIKEN cDNA 1110059E24 gene	3769	0.26
chr1_127899545_127899941	0.40	Rab3gap1	RAB3 GTPase activating protein subunit 1	1170	0.47
chr6_119584715_119585189	0.40	Gm44317	predicted gene, 44317	14011	0.2
chr14_69408593_69408964	0.40	Gm38378	predicted gene, 38378	11007	0.11
chr12_83935202_83935387	0.40	Numb	NUMB endocytic adaptor protein	13360	0.1
chr13_107469451_107469885	0.39	AI197445	expressed sequence AI197445	154	0.97
chr16_24878031_24878240	0.38	Gm22672	predicted gene, 22672	6038	0.25
chr19_44394314_44394509	0.38	Scd1	stearoyl-Coenzyme A desaturase 1	12279	0.14
chr5_125528530_125528687	0.38	Tmem132b	transmembrane protein 132B	3166	0.22
chr18_55182860_55183019	0.38	Gm22597	predicted gene, 22597	3099	0.29
chr16_43168807_43168974	0.38	Gm15712	predicted gene 15712	15683	0.21
chr14_7842334_7842485	0.38	Flnb	filamin, beta	24452	0.15
chr19_40160539_40160690	0.38	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	26672	0.14
chr2_58773911_58774203	0.37	Upp2	uridine phosphorylase 2	8732	0.21
chr8_41202065_41202231	0.37	Fgl1	fibrinogen-like protein 1	13005	0.17
chr17_57205198_57205712	0.37	Tnfsf14	tumor necrosis factor (ligand) superfamily, member 14	11278	0.1
chr2_52579266_52579417	0.37	Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	20774	0.18
chr11_51753632_51753825	0.37	Sec24a	Sec24 related gene family, member A (S. cerevisiae)	2483	0.22
chr11_16588986_16589143	0.36	Gm12663	predicted gene 12663	47002	0.12
chr8_36290613_36290918	0.36	Lonrf1	LON peptidase N-terminal domain and ring finger 1	41249	0.14
chr12_57537784_57538085	0.36	Foxa1	forkhead box A1	8187	0.15
chr5_99474871_99475183	0.36	Gm35172	predicted gene, 35172	33362	0.17
chr14_30542112_30542288	0.36	Tkt	transketolase	6159	0.16
chr2_31487515_31488471	0.36	Ass1	argininosuccinate synthetase 1	9779	0.18
chr8_114152687_114152971	0.35	Nudt7	nudix (nucleoside diphosphate linked moiety X)-type motif 7	19187	0.25
chr2_31497033_31497351	0.35	Ass1	argininosuccinate synthetase 1	580	0.75
chr12_104083020_104083260	0.35	Serpina4-ps1	serine (or cysteine) peptidase inhibitor, clade A, member 4, pseudogene 1	2491	0.16
chr1_67165771_67165961	0.35	Cps1	carbamoyl-phosphate synthetase 1	42840	0.16
chr19_44393747_44393961	0.35	Scd1	stearoyl-Coenzyme A desaturase 1	12836	0.14
chr11_16814206_16814660	0.35	Egfros	epidermal growth factor receptor, opposite strand	16269	0.21
chr10_66914558_66914709	0.35	1110002J07Rik	RIKEN cDNA 1110002J07 gene	3106	0.21
chr1_77279465_77279665	0.35	Epha4	Eph receptor A4	98042	0.08
chr2_58791427_58791720	0.35	Upp2	uridine phosphorylase 2	26248	0.18
chr3_138226845_138227007	0.35	Adh7	alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide	1125	0.38
chr15_10200971_10201518	0.34	Prlr	prolactin receptor	12221	0.28
chr5_92097101_92097294	0.34	G3bp2	GTPase activating protein (SH3 domain) binding protein 2	13478	0.12
chr17_8810128_8810417	0.34	Pde10a	phosphodiesterase 10A	7244	0.26
chr11_90685296_90685460	0.34	Tom1l1	target of myb1-like 1 (chicken)	2201	0.34
chr12_80010993_80011167	0.33	Gm8275	predicted gene 8275	31229	0.14
chr6_71812965_71813119	0.33	Gm44770	predicted gene 44770	10154	0.1
chr19_40174636_40174787	0.33	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	12575	0.15
chr9_21689288_21689439	0.33	Gm26511	predicted gene, 26511	34087	0.09
chr6_50091657_50091996	0.33	Mpp6	membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)	18415	0.22
chr17_46051138_46051309	0.33	Vegfa	vascular endothelial growth factor A	18854	0.13
chr16_65666527_65666684	0.32	Gm49633	predicted gene, 49633	53186	0.14
chr19_55394273_55394505	0.32	Vti1a	vesicle transport through interaction with t-SNAREs 1A	13375	0.25
chr1_74970898_74971209	0.32	Gm37744	predicted gene, 37744	16801	0.11
chr4_84540692_84540849	0.32	Bnc2	basonuclin 2	5520	0.32
chr2_20909493_20909665	0.32	Arhgap21	Rho GTPase activating protein 21	5115	0.23
chr3_18210165_18210316	0.32	Gm23686	predicted gene, 23686	32615	0.17
chr1_67111462_67111613	0.31	Cps1	carbamoyl-phosphate synthetase 1	11489	0.23
chr2_52578719_52578880	0.31	Cacnb4	calcium channel, voltage-dependent, beta 4 subunit	20232	0.18
chr2_92424112_92424429	0.31	Cry2	cryptochrome 2 (photolyase-like)	8122	0.11
chr12_75566070_75566284	0.31	Gm47689	predicted gene, 47689	13688	0.18
chr2_160361611_160362000	0.31	Mafb	v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)	5260	0.27
chr13_43530948_43531160	0.31	Gm32939	predicted gene, 32939	834	0.53
chr11_7815566_7815774	0.31	Gm27393	predicted gene, 27393	70835	0.13
chr19_43496566_43496970	0.31	Cnnm1	cyclin M1	3252	0.16
chr5_112242342_112242634	0.31	Cryba4	crystallin, beta A4	8674	0.11
chr8_64843591_64843742	0.30	Klhl2	kelch-like 2, Mayven	1469	0.34
chr2_160763946_160764097	0.30	Plcg1	phospholipase C, gamma 1	3903	0.2
chr1_36095531_36095713	0.30	Hs6st1	heparan sulfate 6-O-sulfotransferase 1	6068	0.15
chr4_104763940_104764114	0.30	C8b	complement component 8, beta polypeptide	2290	0.4
chr9_74294555_74294732	0.30	Wdr72	WD repeat domain 72	20509	0.23
chrX_166678508_166678678	0.30	Gm1720	predicted gene 1720	16568	0.21
chr7_97413837_97414007	0.30	Thrsp	thyroid hormone responsive	3597	0.16
chr3_94708222_94708411	0.30	Selenbp2	selenium binding protein 2	14657	0.1
chr8_72665230_72665413	0.30	Nwd1	NACHT and WD repeat domain containing 1	8235	0.15
chr10_111150128_111150279	0.30	Gm8873	predicted gene 8873	6013	0.14
chr7_75457902_75458053	0.30	Akap13	A kinase (PRKA) anchor protein 13	2109	0.28
chr15_58983651_58983950	0.29	4930544F09Rik	RIKEN cDNA 4930544F09 gene	336	0.87
chr19_26778139_26778521	0.29	Smarca2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2	6734	0.21
chr4_138516557_138516728	0.29	Camk2n1	calcium/calmodulin-dependent protein kinase II inhibitor 1	62328	0.08
chr11_16828832_16828991	0.29	Egfros	epidermal growth factor receptor, opposite strand	1791	0.4
chr11_99105082_99105257	0.29	Tns4	tensin 4	15863	0.14
chr13_40888163_40888333	0.29	Gcnt2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme	1055	0.36
chr6_66996154_66996403	0.28	Gm36816	predicted gene, 36816	12135	0.12
chr3_28703876_28704177	0.28	Slc2a2	solute carrier family 2 (facilitated glucose transporter), member 2	6009	0.18
chr17_24882806_24883274	0.28	Nubp2	nucleotide binding protein 2	2577	0.11
chr1_61971987_61972299	0.28	Gm29640	predicted gene 29640	9064	0.27
chr8_105091387_105091623	0.28	Ces3b	carboxylesterase 3B	2886	0.14
chr5_90471470_90471733	0.28	Alb	albumin	8901	0.15
chr3_19978796_19978963	0.27	Cp	ceruloplasmin	1749	0.34
chr11_11844304_11844501	0.27	Ddc	dopa decarboxylase	8122	0.18
chr2_72222531_72222771	0.27	Rapgef4os2	Rap guanine nucleotide exchange factor (GEF) 4, opposite strand 2	9651	0.17
chr1_21262098_21262745	0.27	Gsta3	glutathione S-transferase, alpha 3	8900	0.11
chr6_27967952_27968118	0.27	Mir592	microRNA 592	31285	0.23
chr6_66963164_66963414	0.27	Gm36816	predicted gene, 36816	45124	0.08
chr19_58738230_58738402	0.27	Pnliprp1	pancreatic lipase related protein 1	1326	0.36
chr16_42914859_42915016	0.27	Gm19522	predicted gene, 19522	2872	0.25
chr3_18156058_18156209	0.27	Gm23686	predicted gene, 23686	21492	0.21
chr2_122260835_122261566	0.27	Duox2	dual oxidase 2	24369	0.09
chr10_86691292_86691645	0.27	Gm15344	predicted gene 15344	1627	0.16
chr11_16798476_16798627	0.27	Egfros	epidermal growth factor receptor, opposite strand	32151	0.16
chr8_9027955_9028106	0.27	Gm44515	predicted gene 44515	95331	0.06
chr17_84734946_84735097	0.27	Lrpprc	leucine-rich PPR-motif containing	3837	0.21
chr18_9842900_9843072	0.26	Gm23637	predicted gene, 23637	15867	0.13
chr6_149169218_149169449	0.26	Amn1	antagonist of mitotic exit network 1	4038	0.17
chr9_80256438_80256780	0.26	Myo6	myosin VI	5438	0.23
chr11_16763486_16763658	0.26	Egfr	epidermal growth factor receptor	11342	0.2
chr3_95322811_95323271	0.26	Cers2	ceramide synthase 2	2101	0.14
chr6_115238722_115238899	0.26	Syn2	synapsin II	184	0.94
chr10_20749070_20749231	0.26	Gm48651	predicted gene, 48651	6967	0.23
chr13_69532134_69532307	0.26	Tent4a	terminal nucleotidyltransferase 4A	212	0.89
chr8_64777953_64778119	0.26	Klhl2	kelch-like 2, Mayven	21628	0.14
chr15_77384660_77384984	0.26	Gm20688	predicted gene 20688	7559	0.1
chr1_163009105_163009274	0.26	Fmo3	flavin containing monooxygenase 3	24661	0.14
chr19_5794205_5794418	0.26	Malat1	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	2641	0.11
chr14_75284686_75284868	0.26	Zc3h13	zinc finger CCCH type containing 13	391	0.82
chr17_84226805_84226999	0.26	Thada	thyroid adenoma associated	2958	0.24
chr12_100421631_100422293	0.26	Gm48381	predicted gene, 48381	22698	0.15
chr15_3468356_3468528	0.26	Ghr	growth hormone receptor	3202	0.36
chr9_42486993_42487198	0.25	Gm16322	predicted gene 16322	11521	0.18
chr11_21406163_21406488	0.25	Ugp2	UDP-glucose pyrophosphorylase 2	35124	0.11
chr19_40183641_40183792	0.25	Cyp2c70	cytochrome P450, family 2, subfamily c, polypeptide 70	3570	0.19
chr3_60965282_60965682	0.25	P2ry1	purinergic receptor P2Y, G-protein coupled 1	37313	0.16
chr18_4930037_4930197	0.25	Svil	supervillin	8391	0.3
chr3_130440388_130440664	0.25	Col25a1	collagen, type XXV, alpha 1	38290	0.17
chr19_38028254_38028422	0.25	Myof	myoferlin	15013	0.15
chr10_99267793_99268059	0.25	Gm48089	predicted gene, 48089	30	0.95
chr9_21837693_21838006	0.25	Angptl8	angiopoietin-like 8	2339	0.17
chr14_120338170_120338321	0.25	Mbnl2	muscleblind like splicing factor 2	31789	0.19
chr5_116390234_116390471	0.25	4930562A09Rik	RIKEN cDNA 4930562A09 gene	2448	0.2
chr9_96893333_96893484	0.25	Pxylp1	2-phosphoxylose phosphatase 1	739	0.57
chr1_67143038_67143247	0.25	Cps1	carbamoyl-phosphate synthetase 1	20116	0.22
chr1_67214555_67214706	0.25	Gm15668	predicted gene 15668	34570	0.17
chr4_45411492_45411708	0.25	Slc25a51	solute carrier family 25, member 51	2834	0.21
chr2_31503965_31504231	0.25	Ass1	argininosuccinate synthetase 1	3372	0.23
chr5_53992838_53993011	0.25	Stim2	stromal interaction molecule 2	5575	0.27
chr11_16795963_16796156	0.25	Egfros	epidermal growth factor receptor, opposite strand	34643	0.15
chr2_177901070_177901508	0.25	Gm14327	predicted gene 14327	2996	0.19
chr2_134503152_134503303	0.25	Hao1	hydroxyacid oxidase 1, liver	51080	0.18
chr14_17720570_17720721	0.24	Gm48320	predicted gene, 48320	50477	0.16
chr8_93183400_93183567	0.24	Gm45909	predicted gene 45909	7875	0.13
chr11_16818941_16819203	0.24	Egfros	epidermal growth factor receptor, opposite strand	11630	0.22
chr9_55322522_55322738	0.24	Nrg4	neuregulin 4	2557	0.25
chr13_4230959_4231234	0.24	Akr1c19	aldo-keto reductase family 1, member C19	2396	0.22
chr8_93183969_93184163	0.24	Gm45909	predicted gene 45909	7292	0.14
chr7_101106567_101106718	0.24	Fchsd2	FCH and double SH3 domains 2	2091	0.29
chr9_106888296_106888447	0.24	Rbm15b	RNA binding motif protein 15B	943	0.37
chr3_121852936_121853213	0.24	Gm42593	predicted gene 42593	9768	0.15
chr11_120809505_120809952	0.24	Fasn	fatty acid synthase	27	0.95
chr11_53278374_53278525	0.24	Hspa4	heat shock protein 4	11208	0.17

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.1	GO:1903800	positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
0.2	0.8	GO:0072338	creatinine metabolic process(GO:0046449) cellular lactam metabolic process(GO:0072338)
0.2	0.5	GO:0010046	response to mycotoxin(GO:0010046)
0.1	0.3	GO:0019626	short-chain fatty acid catabolic process(GO:0019626)
0.1	0.3	GO:0060523	prostate epithelial cord elongation(GO:0060523)
0.1	0.5	GO:0006526	arginine biosynthetic process(GO:0006526)
0.1	0.4	GO:2001013	epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.1	0.3	GO:1903966	monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.1	0.1	GO:0019676	ammonia assimilation cycle(GO:0019676)
0.1	0.2	GO:1903061	positive regulation of protein lipidation(GO:1903061)
0.1	0.2	GO:1901078	negative regulation of relaxation of muscle(GO:1901078)
0.1	0.2	GO:0006068	ethanol catabolic process(GO:0006068)
0.1	0.2	GO:0071286	cellular response to magnesium ion(GO:0071286)
0.1	0.2	GO:0035887	aortic smooth muscle cell differentiation(GO:0035887)
0.1	0.2	GO:0060741	prostate gland stromal morphogenesis(GO:0060741)
0.1	0.2	GO:1900245	positive regulation of MDA-5 signaling pathway(GO:1900245)
0.1	0.2	GO:0034310	primary alcohol catabolic process(GO:0034310)
0.0	0.1	GO:0042525	tyrosine phosphorylation of Stat6 protein(GO:0042505) regulation of tyrosine phosphorylation of Stat6 protein(GO:0042525)
0.0	0.1	GO:1900169	regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.0	0.2	GO:0010891	negative regulation of sequestering of triglyceride(GO:0010891)
0.0	0.1	GO:0032741	positive regulation of interleukin-18 production(GO:0032741)
0.0	0.1	GO:1902730	regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) positive regulation of proteoglycan biosynthetic process(GO:1902730)
0.0	0.1	GO:0046167	glycerol-3-phosphate biosynthetic process(GO:0046167)
0.0	0.1	GO:0097118	neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
0.0	0.2	GO:0044034	negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.0	0.1	GO:0038161	prolactin signaling pathway(GO:0038161)
0.0	0.1	GO:0006701	progesterone biosynthetic process(GO:0006701)
0.0	1.2	GO:0019373	epoxygenase P450 pathway(GO:0019373)
0.0	0.1	GO:0070672	response to interleukin-15(GO:0070672)
0.0	0.2	GO:2000189	positive regulation of cholesterol homeostasis(GO:2000189)
0.0	0.1	GO:0015817	histidine transport(GO:0015817)
0.0	0.1	GO:0009730	detection of carbohydrate stimulus(GO:0009730) detection of hexose stimulus(GO:0009732) detection of monosaccharide stimulus(GO:0034287) detection of glucose(GO:0051594)
0.0	0.2	GO:0060978	angiogenesis involved in coronary vascular morphogenesis(GO:0060978)
0.0	0.1	GO:0008588	release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.0	0.1	GO:1900041	negative regulation of interleukin-2 secretion(GO:1900041)
0.0	0.1	GO:0006059	hexitol metabolic process(GO:0006059)
0.0	0.1	GO:0060847	endothelial cell fate specification(GO:0060847)
0.0	0.1	GO:0035964	COPI-coated vesicle budding(GO:0035964)
0.0	0.1	GO:0001920	negative regulation of receptor recycling(GO:0001920)
0.0	0.1	GO:2000211	regulation of glutamate metabolic process(GO:2000211)
0.0	0.1	GO:0001996	positive regulation of heart rate by epinephrine-norepinephrine(GO:0001996)
0.0	0.1	GO:2000609	regulation of thyroid hormone generation(GO:2000609)
0.0	0.0	GO:0050747	positive regulation of lipoprotein metabolic process(GO:0050747)
0.0	0.4	GO:0009404	toxin metabolic process(GO:0009404)
0.0	0.1	GO:0046121	deoxyribonucleoside catabolic process(GO:0046121)
0.0	0.1	GO:0014734	skeletal muscle hypertrophy(GO:0014734)
0.0	0.1	GO:0034436	glycoprotein transport(GO:0034436)
0.0	0.2	GO:1902993	positive regulation of beta-amyloid formation(GO:1902004) positive regulation of amyloid precursor protein catabolic process(GO:1902993)
0.0	0.2	GO:1904668	positive regulation of ubiquitin protein ligase activity(GO:1904668)
0.0	0.1	GO:0035283	central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.0	0.1	GO:1902744	negative regulation of lamellipodium organization(GO:1902744)
0.0	0.1	GO:0072602	interleukin-4 secretion(GO:0072602)
0.0	0.1	GO:0050882	voluntary musculoskeletal movement(GO:0050882)
0.0	0.1	GO:1901301	regulation of cargo loading into COPII-coated vesicle(GO:1901301)
0.0	0.1	GO:0070447	positive regulation of oligodendrocyte progenitor proliferation(GO:0070447)
0.0	0.1	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
0.0	0.1	GO:0046061	dATP catabolic process(GO:0046061)
0.0	0.2	GO:1902221	L-phenylalanine metabolic process(GO:0006558) erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process(GO:1902221)
0.0	0.2	GO:0050916	sensory perception of sweet taste(GO:0050916)
0.0	0.2	GO:0050861	positive regulation of B cell receptor signaling pathway(GO:0050861)
0.0	0.2	GO:0019227	neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0	0.7	GO:0045745	positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.0	0.1	GO:0089711	L-glutamate transmembrane transport(GO:0089711)
0.0	0.1	GO:0071798	response to prostaglandin D(GO:0071798) cellular response to prostaglandin D stimulus(GO:0071799)
0.0	0.1	GO:0097029	mature conventional dendritic cell differentiation(GO:0097029)
0.0	0.1	GO:0042276	error-prone translesion synthesis(GO:0042276)
0.0	0.1	GO:1902475	L-alpha-amino acid transmembrane transport(GO:1902475)
0.0	0.1	GO:0071034	CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043)
0.0	0.1	GO:0032474	otolith morphogenesis(GO:0032474)
0.0	0.2	GO:0046069	cGMP catabolic process(GO:0046069)
0.0	0.1	GO:1901300	positive regulation of hydrogen peroxide-mediated programmed cell death(GO:1901300) positive regulation of hydrogen peroxide-induced cell death(GO:1905206)
0.0	0.2	GO:0098908	regulation of neuronal action potential(GO:0098908)
0.0	0.0	GO:0006600	creatine metabolic process(GO:0006600)
0.0	0.1	GO:0044598	polyketide metabolic process(GO:0030638) aminoglycoside antibiotic metabolic process(GO:0030647) daunorubicin metabolic process(GO:0044597) doxorubicin metabolic process(GO:0044598)
0.0	0.1	GO:1904479	negative regulation of intestinal absorption(GO:1904479)
0.0	0.0	GO:1900736	regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900736)
0.0	0.1	GO:0032696	negative regulation of interleukin-13 production(GO:0032696)
0.0	0.1	GO:0048850	hypophysis morphogenesis(GO:0048850)
0.0	0.1	GO:0000957	mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.0	0.1	GO:0031627	telomeric loop formation(GO:0031627)
0.0	0.1	GO:0051684	maintenance of Golgi location(GO:0051684)
0.0	0.0	GO:0003223	ventricular compact myocardium morphogenesis(GO:0003223)
0.0	0.2	GO:0016264	gap junction assembly(GO:0016264)
0.0	0.1	GO:0002576	platelet degranulation(GO:0002576)
0.0	0.0	GO:0050883	musculoskeletal movement, spinal reflex action(GO:0050883)
0.0	0.1	GO:0060448	dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0	0.1	GO:0019805	quinolinate biosynthetic process(GO:0019805)
0.0	0.1	GO:0050847	progesterone receptor signaling pathway(GO:0050847)
0.0	0.1	GO:0061641	CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.0	0.0	GO:1903371	regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.0	0.1	GO:1902071	regulation of hypoxia-inducible factor-1alpha signaling pathway(GO:1902071)
0.0	0.1	GO:0060613	fat pad development(GO:0060613)
0.0	0.1	GO:0031087	nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.0	0.1	GO:0035589	G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.0	0.1	GO:0031118	rRNA pseudouridine synthesis(GO:0031118)
0.0	0.1	GO:2000324	positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
0.0	0.1	GO:0018125	peptidyl-cysteine methylation(GO:0018125)
0.0	0.1	GO:0006106	fumarate metabolic process(GO:0006106)
0.0	0.1	GO:0015074	DNA integration(GO:0015074)
0.0	0.0	GO:2000017	positive regulation of determination of dorsal identity(GO:2000017)
0.0	0.1	GO:0046060	dATP metabolic process(GO:0046060)
0.0	0.1	GO:1902414	protein localization to cell junction(GO:1902414)
0.0	0.1	GO:0060283	negative regulation of oocyte development(GO:0060283)
0.0	0.2	GO:0006957	complement activation, alternative pathway(GO:0006957)
0.0	0.1	GO:0098700	aminergic neurotransmitter loading into synaptic vesicle(GO:0015842) neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0	0.1	GO:0071051	polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
0.0	0.1	GO:0070837	dehydroascorbic acid transport(GO:0070837)
0.0	0.1	GO:0006048	UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.0	0.1	GO:0060355	positive regulation of cell adhesion molecule production(GO:0060355)
0.0	0.1	GO:2000664	positive regulation of interleukin-5 secretion(GO:2000664) positive regulation of interleukin-13 secretion(GO:2000667)
0.0	0.1	GO:0061051	positive regulation of cell growth involved in cardiac muscle cell development(GO:0061051)
0.0	0.1	GO:0042448	progesterone metabolic process(GO:0042448)
0.0	0.1	GO:0006646	phosphatidylethanolamine biosynthetic process(GO:0006646)
0.0	0.2	GO:0006120	mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.0	0.1	GO:0009052	pentose-phosphate shunt, non-oxidative branch(GO:0009052)
0.0	0.1	GO:0009068	aspartate family amino acid catabolic process(GO:0009068)
0.0	0.1	GO:0001907	killing by symbiont of host cells(GO:0001907) disruption by symbiont of host cell(GO:0044004)
0.0	0.1	GO:0003406	retinal pigment epithelium development(GO:0003406)
0.0	0.1	GO:0009235	cobalamin metabolic process(GO:0009235)
0.0	0.0	GO:1901420	negative regulation of response to alcohol(GO:1901420)
0.0	0.0	GO:0090135	actin filament branching(GO:0090135)
0.0	0.1	GO:0034638	phosphatidylcholine catabolic process(GO:0034638)
0.0	0.0	GO:0034454	microtubule anchoring at centrosome(GO:0034454)
0.0	0.1	GO:0015015	heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
0.0	0.1	GO:0070189	kynurenine metabolic process(GO:0070189)
0.0	0.4	GO:0006084	acetyl-CoA metabolic process(GO:0006084)
0.0	0.1	GO:0006537	glutamate biosynthetic process(GO:0006537)
0.0	0.1	GO:0070966	nuclear-transcribed mRNA catabolic process, no-go decay(GO:0070966)
0.0	0.0	GO:0036506	maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.0	0.1	GO:0019262	N-acetylneuraminate catabolic process(GO:0019262)
0.0	0.1	GO:0006108	malate metabolic process(GO:0006108)
0.0	0.0	GO:0070836	plasma membrane raft assembly(GO:0044854) plasma membrane raft organization(GO:0044857) caveola assembly(GO:0070836)
0.0	0.2	GO:0006857	oligopeptide transport(GO:0006857)
0.0	0.0	GO:1902683	regulation of receptor localization to synapse(GO:1902683)
0.0	0.1	GO:0042989	sequestering of actin monomers(GO:0042989)
0.0	0.0	GO:0045658	regulation of neutrophil differentiation(GO:0045658)
0.0	0.0	GO:0006549	isoleucine metabolic process(GO:0006549)
0.0	0.1	GO:0002901	mature B cell apoptotic process(GO:0002901) regulation of mature B cell apoptotic process(GO:0002905) negative regulation of mature B cell apoptotic process(GO:0002906)
0.0	0.1	GO:0034242	negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.0	0.0	GO:1903659	regulation of complement-dependent cytotoxicity(GO:1903659) negative regulation of complement-dependent cytotoxicity(GO:1903660)
0.0	0.0	GO:1904694	negative regulation of vascular smooth muscle contraction(GO:1904694)
0.0	0.0	GO:0032483	regulation of Rab protein signal transduction(GO:0032483)
0.0	0.1	GO:0035435	phosphate ion transmembrane transport(GO:0035435)
0.0	0.0	GO:0003431	growth plate cartilage chondrocyte development(GO:0003431)
0.0	0.1	GO:0052697	xenobiotic glucuronidation(GO:0052697)
0.0	0.0	GO:0045901	positive regulation of translational elongation(GO:0045901)
0.0	0.0	GO:1990928	response to amino acid starvation(GO:1990928)
0.0	0.0	GO:0017187	peptidyl-glutamic acid carboxylation(GO:0017187)
0.0	0.1	GO:0070417	cellular response to cold(GO:0070417)
0.0	0.1	GO:0032237	activation of store-operated calcium channel activity(GO:0032237)
0.0	0.1	GO:0006490	oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0	0.1	GO:0045348	positive regulation of MHC class II biosynthetic process(GO:0045348)
0.0	0.1	GO:0003176	aortic valve development(GO:0003176) aortic valve morphogenesis(GO:0003180)
0.0	0.0	GO:0021847	ventricular zone neuroblast division(GO:0021847)
0.0	0.0	GO:1903265	positive regulation of tumor necrosis factor-mediated signaling pathway(GO:1903265)
0.0	0.3	GO:0006783	heme biosynthetic process(GO:0006783)
0.0	0.1	GO:1901407	regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901407) positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.0	0.1	GO:0006103	2-oxoglutarate metabolic process(GO:0006103)
0.0	0.0	GO:2001180	negative regulation of interleukin-10 secretion(GO:2001180)
0.0	0.1	GO:1902373	negative regulation of RNA catabolic process(GO:1902369) negative regulation of mRNA catabolic process(GO:1902373)
0.0	0.1	GO:1903242	regulation of cardiac muscle adaptation(GO:0010612) regulation of cardiac muscle hypertrophy in response to stress(GO:1903242)
0.0	0.0	GO:0045950	negative regulation of mitotic recombination(GO:0045950)
0.0	0.0	GO:0021747	cochlear nucleus development(GO:0021747)
0.0	0.1	GO:0032959	inositol trisphosphate biosynthetic process(GO:0032959)
0.0	0.0	GO:0035054	embryonic heart tube anterior/posterior pattern specification(GO:0035054)
0.0	0.0	GO:1900045	negative regulation of protein K63-linked ubiquitination(GO:1900045) negative regulation of protein polyubiquitination(GO:1902915)
0.0	0.0	GO:0001827	inner cell mass cell fate commitment(GO:0001827)
0.0	0.0	GO:0019695	choline metabolic process(GO:0019695)
0.0	0.0	GO:2000427	positive regulation of apoptotic cell clearance(GO:2000427)
0.0	0.0	GO:0016080	synaptic vesicle targeting(GO:0016080)
0.0	0.1	GO:0030644	cellular chloride ion homeostasis(GO:0030644)
0.0	0.1	GO:0015886	heme transport(GO:0015886)
0.0	0.0	GO:0070949	regulation of neutrophil mediated cytotoxicity(GO:0070948) regulation of neutrophil mediated killing of symbiont cell(GO:0070949)
0.0	0.0	GO:0006069	ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069)
0.0	0.0	GO:0061144	alveolar secondary septum development(GO:0061144)
0.0	0.0	GO:1903300	negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.0	0.0	GO:0016557	peroxisome membrane biogenesis(GO:0016557)
0.0	0.0	GO:0036394	amylase secretion(GO:0036394)
0.0	0.0	GO:0072307	metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
0.0	0.1	GO:1903961	positive regulation of anion transmembrane transport(GO:1903961)
0.0	0.0	GO:0021823	cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
0.0	0.1	GO:0061484	hematopoietic stem cell homeostasis(GO:0061484)
0.0	0.0	GO:0019482	beta-alanine metabolic process(GO:0019482)
0.0	0.0	GO:0036022	limb joint morphogenesis(GO:0036022) embryonic skeletal limb joint morphogenesis(GO:0036023)
0.0	0.1	GO:0046784	viral mRNA export from host cell nucleus(GO:0046784)
0.0	0.1	GO:0007256	activation of JNKK activity(GO:0007256)
0.0	0.0	GO:2000535	entry of bacterium into host cell(GO:0035635) regulation of entry of bacterium into host cell(GO:2000535)
0.0	0.1	GO:0071712	ER-associated misfolded protein catabolic process(GO:0071712)
0.0	0.0	GO:0060300	regulation of cytokine activity(GO:0060300)
0.0	0.1	GO:0043545	Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189)
0.0	0.1	GO:0006013	mannose metabolic process(GO:0006013)
0.0	0.1	GO:0007252	I-kappaB phosphorylation(GO:0007252)
0.0	0.0	GO:0060468	prevention of polyspermy(GO:0060468)
0.0	0.0	GO:0006244	pyrimidine nucleotide catabolic process(GO:0006244)
0.0	0.0	GO:0060385	axonogenesis involved in innervation(GO:0060385)
0.0	0.0	GO:0060666	dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0	0.2	GO:0032728	positive regulation of interferon-beta production(GO:0032728)
0.0	0.0	GO:0014722	regulation of skeletal muscle contraction by calcium ion signaling(GO:0014722)
0.0	0.0	GO:0042758	long-chain fatty acid catabolic process(GO:0042758)
0.0	0.1	GO:0071360	cellular response to exogenous dsRNA(GO:0071360)
0.0	0.1	GO:0060252	positive regulation of glial cell proliferation(GO:0060252)
0.0	0.0	GO:0046104	thymidine metabolic process(GO:0046104)
0.0	0.3	GO:0000381	regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0	0.1	GO:0051005	negative regulation of lipoprotein lipase activity(GO:0051005)
0.0	0.0	GO:0009957	epidermal cell fate specification(GO:0009957)
0.0	0.0	GO:1990168	protein K29-linked deubiquitination(GO:0035523) protein K33-linked deubiquitination(GO:1990168)
0.0	0.1	GO:0046628	positive regulation of insulin receptor signaling pathway(GO:0046628)
0.0	0.1	GO:0009256	10-formyltetrahydrofolate metabolic process(GO:0009256)
0.0	0.2	GO:0010257	NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0	0.0	GO:0071926	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926)
0.0	0.0	GO:0000389	mRNA 3'-splice site recognition(GO:0000389)
0.0	0.1	GO:0007144	female meiosis I(GO:0007144)
0.0	0.0	GO:0070682	proteasome regulatory particle assembly(GO:0070682)
0.0	0.0	GO:0002784	regulation of antimicrobial peptide production(GO:0002784) regulation of antibacterial peptide production(GO:0002786)
0.0	0.0	GO:0061368	behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)

Gene overrepresentation in cellular component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.1	GO:0097487	multivesicular body, internal vesicle(GO:0097487)
0.1	0.5	GO:0045098	type III intermediate filament(GO:0045098)
0.1	0.2	GO:0097454	Schwann cell microvillus(GO:0097454)
0.0	0.2	GO:0044316	cone cell pedicle(GO:0044316)
0.0	0.5	GO:0070852	cell body fiber(GO:0070852)
0.0	0.2	GO:0032541	cortical endoplasmic reticulum(GO:0032541)
0.0	0.2	GO:0030127	COPII vesicle coat(GO:0030127)
0.0	0.2	GO:0016942	insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) insulin-like growth factor ternary complex(GO:0042567)
0.0	0.1	GO:0031088	platelet dense granule membrane(GO:0031088)
0.0	0.2	GO:0005579	membrane attack complex(GO:0005579)
0.0	0.2	GO:0042587	glycogen granule(GO:0042587)
0.0	0.1	GO:0012507	ER to Golgi transport vesicle membrane(GO:0012507)
0.0	0.2	GO:0071782	endoplasmic reticulum tubular network(GO:0071782)
0.0	0.1	GO:0071203	WASH complex(GO:0071203)
0.0	0.1	GO:0005899	insulin receptor complex(GO:0005899)
0.0	0.2	GO:0036513	Derlin-1 retrotranslocation complex(GO:0036513)
0.0	0.1	GO:0032010	phagolysosome(GO:0032010)
0.0	0.1	GO:0005712	chiasma(GO:0005712)
0.0	0.1	GO:0019907	cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0	0.1	GO:0001652	granular component(GO:0001652)
0.0	0.2	GO:0016342	catenin complex(GO:0016342)
0.0	0.1	GO:0090661	box H/ACA telomerase RNP complex(GO:0090661)
0.0	0.1	GO:0072357	PTW/PP1 phosphatase complex(GO:0072357)
0.0	0.1	GO:0032009	early phagosome(GO:0032009)
0.0	0.2	GO:0071564	npBAF complex(GO:0071564)
0.0	0.1	GO:0097433	dense body(GO:0097433)
0.0	0.2	GO:0031254	uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0	0.3	GO:0035327	transcriptionally active chromatin(GO:0035327)
0.0	0.0	GO:0097413	Lewy body(GO:0097413)
0.0	0.0	GO:0070939	Dsl1p complex(GO:0070939)
0.0	0.0	GO:0070765	gamma-secretase complex(GO:0070765)
0.0	0.2	GO:0000930	gamma-tubulin complex(GO:0000930)
0.0	0.0	GO:0072379	BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.0	0.1	GO:0031315	extrinsic component of mitochondrial outer membrane(GO:0031315)
0.0	0.0	GO:0005955	calcineurin complex(GO:0005955)
0.0	0.2	GO:0000177	cytoplasmic exosome (RNase complex)(GO:0000177)
0.0	0.0	GO:0005850	eukaryotic translation initiation factor 2 complex(GO:0005850)
0.0	0.1	GO:0070775	H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0	0.1	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.0	0.0	GO:0042827	platelet dense granule(GO:0042827)
0.0	0.1	GO:0031298	replication fork protection complex(GO:0031298)
0.0	0.0	GO:0048179	activin receptor complex(GO:0048179)
0.0	0.0	GO:0031094	platelet dense tubular network(GO:0031094)
0.0	0.1	GO:0033588	Elongator holoenzyme complex(GO:0033588)
0.0	0.1	GO:0030126	COPI vesicle coat(GO:0030126)
0.0	0.0	GO:0005863	striated muscle myosin thick filament(GO:0005863)
0.0	0.0	GO:0070552	BRISC complex(GO:0070552)
0.0	0.1	GO:0031462	Cul2-RING ubiquitin ligase complex(GO:0031462)
0.0	0.0	GO:0097451	glial limiting end-foot(GO:0097451)
0.0	0.0	GO:0043625	delta DNA polymerase complex(GO:0043625)
0.0	0.0	GO:0060053	neurofilament cytoskeleton(GO:0060053)
0.0	0.1	GO:0000347	THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.0	0.0	GO:0032021	NELF complex(GO:0032021)
0.0	0.0	GO:0016222	procollagen-proline 4-dioxygenase complex(GO:0016222)
0.0	0.1	GO:0044294	dendritic growth cone(GO:0044294)
0.0	0.0	GO:0005610	laminin-5 complex(GO:0005610)
0.0	0.0	GO:0097450	astrocyte end-foot(GO:0097450)
0.0	0.2	GO:0034451	centriolar satellite(GO:0034451)
0.0	0.1	GO:0061617	MICOS complex(GO:0061617)
0.0	0.1	GO:0008385	IkappaB kinase complex(GO:0008385)
0.0	0.0	GO:0097209	epidermal lamellar body(GO:0097209)

Gene overrepresentation in molecular function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.1	GO:0005006	epidermal growth factor-activated receptor activity(GO:0005006)
0.2	0.5	GO:0016743	carboxyl- or carbamoyltransferase activity(GO:0016743)
0.1	0.3	GO:0071614	linoleic acid epoxygenase activity(GO:0071614)
0.1	0.3	GO:0032896	palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.1	0.3	GO:0034056	estrogen response element binding(GO:0034056)
0.1	0.9	GO:0047555	3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.1	0.2	GO:0004771	sterol esterase activity(GO:0004771)
0.1	0.1	GO:0038181	bile acid receptor activity(GO:0038181)
0.1	0.2	GO:0004024	alcohol dehydrogenase activity, zinc-dependent(GO:0004024)
0.0	0.1	GO:0070644	vitamin D response element binding(GO:0070644)
0.0	0.1	GO:0004768	stearoyl-CoA 9-desaturase activity(GO:0004768)
0.0	0.1	GO:0004937	alpha1-adrenergic receptor activity(GO:0004937)
0.0	0.5	GO:0015643	toxic substance binding(GO:0015643)
0.0	0.2	GO:0004566	beta-glucuronidase activity(GO:0004566)
0.0	0.2	GO:0030229	very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0	0.1	GO:0015182	L-asparagine transmembrane transporter activity(GO:0015182) L-glutamine transmembrane transporter activity(GO:0015186)
0.0	0.2	GO:0050815	phosphoserine binding(GO:0050815)
0.0	0.2	GO:0010997	anaphase-promoting complex binding(GO:0010997)
0.0	0.0	GO:0008905	mannose-phosphate guanylyltransferase activity(GO:0008905)
0.0	0.1	GO:0004103	choline kinase activity(GO:0004103)
0.0	0.1	GO:0003986	acetyl-CoA hydrolase activity(GO:0003986)
0.0	0.1	GO:0004370	glycerol kinase activity(GO:0004370)
0.0	0.1	GO:0004470	malic enzyme activity(GO:0004470) malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471)
0.0	0.3	GO:0004312	fatty acid synthase activity(GO:0004312)
0.0	0.1	GO:0005220	inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.0	0.2	GO:0047760	butyrate-CoA ligase activity(GO:0047760)
0.0	0.1	GO:0070548	L-glutamine aminotransferase activity(GO:0070548)
0.0	0.0	GO:0008948	oxaloacetate decarboxylase activity(GO:0008948)
0.0	0.2	GO:0015198	oligopeptide transporter activity(GO:0015198)
0.0	0.1	GO:0032190	acrosin binding(GO:0032190)
0.0	0.1	GO:0016899	oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor(GO:0016899)
0.0	0.0	GO:0050051	leukotriene-B4 20-monooxygenase activity(GO:0050051)
0.0	0.2	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0	0.1	GO:0004366	glycerol-3-phosphate O-acyltransferase activity(GO:0004366)
0.0	0.1	GO:0008532	N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.0	0.1	GO:0031686	A1 adenosine receptor binding(GO:0031686)
0.0	0.1	GO:0004505	phenylalanine 4-monooxygenase activity(GO:0004505)
0.0	0.1	GO:0030984	kininogen binding(GO:0030984)
0.0	0.2	GO:0050308	sugar-phosphatase activity(GO:0050308)
0.0	0.1	GO:0036042	long-chain fatty acyl-CoA binding(GO:0036042)
0.0	0.3	GO:0008349	MAP kinase kinase kinase kinase activity(GO:0008349)
0.0	0.1	GO:0000064	L-ornithine transmembrane transporter activity(GO:0000064)
0.0	0.1	GO:0004793	threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
0.0	0.4	GO:0030552	cAMP binding(GO:0030552)
0.0	0.1	GO:0008597	calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.0	0.2	GO:0045322	unmethylated CpG binding(GO:0045322)
0.0	0.1	GO:0034513	box H/ACA snoRNA binding(GO:0034513)
0.0	0.2	GO:0045294	alpha-catenin binding(GO:0045294)
0.0	0.4	GO:0003785	actin monomer binding(GO:0003785)
0.0	0.2	GO:0008331	high voltage-gated calcium channel activity(GO:0008331)
0.0	0.0	GO:0016822	hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
0.0	0.1	GO:0055056	D-glucose transmembrane transporter activity(GO:0055056)
0.0	0.2	GO:0070569	uridylyltransferase activity(GO:0070569)
0.0	0.1	GO:0016174	NAD(P)H oxidase activity(GO:0016174)
0.0	0.1	GO:0045504	dynein heavy chain binding(GO:0045504)
0.0	0.6	GO:0080030	prenylcysteine methylesterase activity(GO:0010296) 1-oxa-2-oxocycloheptane lactonase activity(GO:0018731) sulfolactone hydrolase activity(GO:0018732) butyrolactone hydrolase activity(GO:0018734) endosulfan lactone lactonase activity(GO:0034892) L-ascorbate 6-phosphate lactonase activity(GO:0035460) Ser-tRNA(Thr) hydrolase activity(GO:0043905) Ala-tRNA(Pro) hydrolase activity(GO:0043906) Cys-tRNA(Pro) hydrolase activity(GO:0043907) Ser(Gly)-tRNA(Ala) hydrolase activity(GO:0043908) all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity(GO:0047376) mannosyl-oligosaccharide 1,6-alpha-mannosidase activity(GO:0052767) mannosyl-oligosaccharide 1,3-alpha-mannosidase activity(GO:0052768) methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032)
0.0	0.1	GO:1990932	5.8S rRNA binding(GO:1990932)
0.0	0.0	GO:0030350	iron-responsive element binding(GO:0030350)
0.0	0.6	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
0.0	0.1	GO:0004340	glucokinase activity(GO:0004340) hexokinase activity(GO:0004396)
0.0	0.0	GO:0001224	RNA polymerase II transcription cofactor binding(GO:0001224)
0.0	0.1	GO:0034875	oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875)
0.0	0.0	GO:0097108	hedgehog family protein binding(GO:0097108)
0.0	0.0	GO:0003941	L-serine ammonia-lyase activity(GO:0003941)
0.0	0.0	GO:0004999	vasoactive intestinal polypeptide receptor activity(GO:0004999)
0.0	0.0	GO:0008199	ferric iron binding(GO:0008199)
0.0	0.1	GO:0043426	MRF binding(GO:0043426)
0.0	0.1	GO:0004571	mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.0	0.2	GO:0048038	quinone binding(GO:0048038)
0.0	0.1	GO:0016715	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715)
0.0	0.1	GO:0003993	acid phosphatase activity(GO:0003993)
0.0	0.0	GO:0004833	tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0	0.3	GO:0008266	poly(U) RNA binding(GO:0008266)
0.0	0.1	GO:0004534	5'-3' exoribonuclease activity(GO:0004534)
0.0	0.1	GO:0004322	ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.0	0.1	GO:0004679	AMP-activated protein kinase activity(GO:0004679)
0.0	0.1	GO:0008430	selenium binding(GO:0008430)
0.0	0.1	GO:0005168	neurotrophin TRKA receptor binding(GO:0005168)
0.0	0.1	GO:0031419	cobalamin binding(GO:0031419)
0.0	0.2	GO:0005159	insulin-like growth factor receptor binding(GO:0005159)
0.0	0.0	GO:0016635	oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0	0.1	GO:0001025	RNA polymerase III transcription factor binding(GO:0001025)
0.0	0.0	GO:0045340	mercury ion binding(GO:0045340)
0.0	0.1	GO:0050291	sphingosine N-acyltransferase activity(GO:0050291)
0.0	0.0	GO:0045134	uridine-diphosphatase activity(GO:0045134)
0.0	0.1	GO:0002046	opsin binding(GO:0002046)
0.0	0.1	GO:0005324	long-chain fatty acid transporter activity(GO:0005324)
0.0	0.0	GO:0046573	lactonohydrolase activity(GO:0046573) acyl-L-homoserine-lactone lactonohydrolase activity(GO:0102007)
0.0	0.1	GO:0005078	MAP-kinase scaffold activity(GO:0005078)
0.0	0.1	GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.0	0.1	GO:0019237	centromeric DNA binding(GO:0019237)
0.0	0.1	GO:0043184	vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.0	0.1	GO:0004035	alkaline phosphatase activity(GO:0004035)
0.0	0.1	GO:0042043	neurexin family protein binding(GO:0042043)
0.0	0.1	GO:0033142	progesterone receptor binding(GO:0033142)
0.0	0.0	GO:0004802	transketolase activity(GO:0004802)
0.0	0.1	GO:0070579	methylcytosine dioxygenase activity(GO:0070579)
0.0	0.0	GO:0034929	fluorene oxygenase activity(GO:0018585) mono-butyltin dioxygenase activity(GO:0018586) tri-n-butyltin dioxygenase activity(GO:0018588) di-n-butyltin dioxygenase activity(GO:0018589) methylsilanetriol hydroxylase activity(GO:0018590) methyl tertiary butyl ether 3-monooxygenase activity(GO:0018591) 4-nitrocatechol 4-monooxygenase activity(GO:0018592) 4-chlorophenoxyacetate monooxygenase activity(GO:0018593) tert-butanol 2-monooxygenase activity(GO:0018594) alpha-pinene monooxygenase activity(GO:0018595) dimethylsilanediol hydroxylase activity(GO:0018596) ammonia monooxygenase activity(GO:0018597) hydroxymethylsilanetriol oxidase activity(GO:0018598) 2-hydroxyisobutyrate 3-monooxygenase activity(GO:0018599) alpha-pinene dehydrogenase activity(GO:0018600) bisphenol A hydroxylase B activity(GO:0034559) 2,2-bis(4-hydroxyphenyl)-1-propanol hydroxylase activity(GO:0034562) 9-fluorenone-3,4-dioxygenase activity(GO:0034786) anthracene 9,10-dioxygenase activity(GO:0034816) 2-(methylthio)benzothiazole monooxygenase activity(GO:0034857) 2-hydroxybenzothiazole monooxygenase activity(GO:0034858) benzothiazole monooxygenase activity(GO:0034859) 2,6-dihydroxybenzothiazole monooxygenase activity(GO:0034862) pinacolone 5-monooxygenase activity(GO:0034870) thioacetamide S-oxygenase activity(GO:0034873) thioacetamide S-oxide S-oxygenase activity(GO:0034874) endosulfan monooxygenase I activity(GO:0034888) N-nitrodimethylamine hydroxylase activity(GO:0034893) 4-(1-ethyl-1,4-dimethyl-pentyl)phenol monoxygenase activity(GO:0034897) endosulfan ether monooxygenase activity(GO:0034903) pyrene 4,5-monooxygenase activity(GO:0034925) pyrene 1,2-monooxygenase activity(GO:0034927) 1-hydroxypyrene 6,7-monooxygenase activity(GO:0034928) 1-hydroxypyrene 7,8-monooxygenase activity(GO:0034929) phenylboronic acid monooxygenase activity(GO:0034950) spheroidene monooxygenase activity(GO:0043823)
0.0	0.0	GO:0042296	ISG15 transferase activity(GO:0042296)
0.0	0.1	GO:0008195	phosphatidate phosphatase activity(GO:0008195)
0.0	0.1	GO:0030368	interleukin-17 receptor activity(GO:0030368)
0.0	0.0	GO:0002094	polyprenyltransferase activity(GO:0002094)
0.0	0.0	GO:0004614	phosphoglucomutase activity(GO:0004614)
0.0	0.1	GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0	0.0	GO:0004726	non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0	0.1	GO:0004311	farnesyltranstransferase activity(GO:0004311)
0.0	0.1	GO:0008420	CTD phosphatase activity(GO:0008420)
0.0	0.1	GO:0004634	phosphopyruvate hydratase activity(GO:0004634)
0.0	0.0	GO:0016286	small conductance calcium-activated potassium channel activity(GO:0016286)
0.0	0.0	GO:0016401	palmitoyl-CoA oxidase activity(GO:0016401)
0.0	0.0	GO:0008384	IkappaB kinase activity(GO:0008384)
0.0	0.1	GO:0030957	Tat protein binding(GO:0030957)
0.0	0.1	GO:0035312	5'-3' exodeoxyribonuclease activity(GO:0035312)
0.0	0.0	GO:0043423	3-phosphoinositide-dependent protein kinase binding(GO:0043423)
0.0	0.1	GO:0043560	insulin receptor substrate binding(GO:0043560)
0.0	0.1	GO:0005243	gap junction channel activity(GO:0005243)
0.0	0.0	GO:0042731	PH domain binding(GO:0042731)
0.0	0.4	GO:0017046	peptide hormone binding(GO:0017046)
0.0	0.1	GO:0045295	gamma-catenin binding(GO:0045295)
0.0	0.0	GO:0042289	MHC class II protein binding(GO:0042289)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.3	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.0	0.8	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.0	0.1	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.0	0.5	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.0	0.5	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.0	0.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta
0.0	0.1	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.0	0.0	PID THROMBIN PAR4 PATHWAY	PAR4-mediated thrombin signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.1	1.2	REACTOME SHC1 EVENTS IN EGFR SIGNALING	Genes involved in SHC1 events in EGFR signaling
0.0	0.4	REACTOME PROLACTIN RECEPTOR SIGNALING	Genes involved in Prolactin receptor signaling
0.0	0.0	REACTOME DNA REPLICATION	Genes involved in DNA Replication
0.0	0.1	REACTOME XENOBIOTICS	Genes involved in Xenobiotics
0.0	0.0	REACTOME ALPHA LINOLENIC ACID ALA METABOLISM	Genes involved in alpha-linolenic acid (ALA) metabolism
0.0	0.5	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.0	0.2	REACTOME SHC1 EVENTS IN ERBB4 SIGNALING	Genes involved in SHC1 events in ERBB4 signaling
0.0	0.2	REACTOME SYNTHESIS OF PE	Genes involved in Synthesis of PE
0.0	0.0	REACTOME GROWTH HORMONE RECEPTOR SIGNALING	Genes involved in Growth hormone receptor signaling
0.0	0.2	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
0.0	0.0	REACTOME ACTIVATION OF GENES BY ATF4	Genes involved in Activation of Genes by ATF4
0.0	0.3	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.0	0.2	REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR	Genes involved in Trafficking and processing of endosomal TLR
0.0	0.0	REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE	Genes involved in NGF signalling via TRKA from the plasma membrane
0.0	0.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.0	0.1	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
0.0	0.1	REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Glutamate Neurotransmitter Release Cycle
0.0	0.2	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0	0.1	REACTOME ETHANOL OXIDATION	Genes involved in Ethanol oxidation
0.0	0.4	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
0.0	0.2	REACTOME DESTABILIZATION OF MRNA BY BRF1	Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.0	0.0	REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	Genes involved in CD28 dependent PI3K/Akt signaling
0.0	0.0	REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH	Genes involved in NCAM signaling for neurite out-growth
0.0	0.2	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.0	0.1	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
0.0	0.1	REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK	Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0	0.2	REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN	Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.0	0.2	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly
0.0	0.3	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.0	0.1	REACTOME RAP1 SIGNALLING	Genes involved in Rap1 signalling
0.0	0.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
0.0	0.2	REACTOME DARPP 32 EVENTS	Genes involved in DARPP-32 events
0.0	0.2	REACTOME CHOLESTEROL BIOSYNTHESIS	Genes involved in Cholesterol biosynthesis
0.0	0.3	REACTOME MYOGENESIS	Genes involved in Myogenesis
0.0	0.2	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions

Results for Pax8

Z-value: 1.66

Motif logo

Transcription factors associated with Pax8

Correlations of motif activity and signal intensity at CREs associated with the motif's TFs:

This plot shows correlation between observed signal intensity of a CRE associated with the transcription factor across all samples and activity of the motif.

For each TF, only the top 5 correlated CREs are shown.

Activity of the Pax8 motif across conditions

Conditions sorted by the z-value of the Pax8 motif activity

Top target CREs of the motif:

Histogram of CRE-TSS distances for CREs targeted by :

Rank distribution of CRE target scores:

Distribution of target CREs across different genomic regions:

Network of associatons between targets according to the STRING database.

First level regulatory network of Pax8

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: